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Cell Transplantation

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https://www.readbyqxmd.com/read/28337957/transplantation-of-cultured-olfactory-bulb-cells-prevents-abnormal-sensory-responses-during-recovery-from-dorsal-root-avulsion-in-the-rat
#1
Andrew Collins, Daqing Li, Stephen B McMahon, Geoffrey Raisman, Ying Li
The central branches of the C7 and C8 dorsal roots were avulsed close to their entry point into the spinal cord in adult rats. The forepaw responses to heat and cold stimuli were tested at 1, 2 and 3 weeks after injury. Over this period the paws were sensitive to both stimuli at 1-2 weeks and returned towards normal at 3 weeks. Immunohistology showed no evidence of axonal regeneration into the spinal cord in a control group of rats with avulsion only, implying that adjacent dorsal roots and their corresponding dermatomes were involved in the recovery...
March 23, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28337956/acute-renal-graft-versus-host-disease-in-a-murine-model-of-allogeneic-bone-marrow-transplantation
#2
Peter M Schmid, Abdellatif Bouazzaoui, Karin Schmid, Christoph Birner, Christian Schach, Lars S Maier, Ernst Holler, Dierk H Endemann
Acute kidney injury (AKI) is a very common complication after allogeneic bone marrow transplantation (BMT) and associated with poor prognosis. Generally kidneys are assumed to be no direct target of Graft-versus-Host Disease (GvHD), and renal impairment is often attributed to several other factors occurring in the early phase after BMT. Our study aimed to prove the existence of renal GvHD in a fully MHC-mismatched model of BALB/c mice conditioned and transplanted according to two different intensity protocols...
March 23, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28315294/neuronal-cell-sheet-of-cortical-motor-neuron-phenotype-derived-from-human-ips-cells
#3
Noboru Suzuki, Nagisa Arimitsu, Jun Shimizu, Kenji Takai, Chieko Hirotsu, Erika Takada, Yuji Ueda, Sueshige Wakisaka, Naruyoshi Fujiwara, Tomoko Suzuki
<p>Transplantation of stem cells which differentiate into more mature neural cells brings about functional improvement in pre-clinical studies of stroke. Previous transplant approaches in diseased brain have utilized injection of the cells in a cell suspension. In addition, neural stem cells were preferentially used as graft. However, these cells had no specific relationship to the damaged tissue of stroke patients and brain injury. The injection of cells in a suspension destroyed the cell-cell interactions that are suggested to be important for promoting functional integrity as cortical motor neurons...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28315292/hypoxic-culture-promotes-dopaminergic-neuronal-differentiation-of-nasal-olfactory-mucosa-mesenchymal-stem-cells-via-up-regulation-of-hypoxia-inducible-factor-1%C3%AE
#4
Yi Zhuo, Lei Wang, Lite Ge, Xuan Li, Ping Chen, Da Duan, Xiaohua Teng, Miao Jiang, Kai Liu, Ting Yuan, Pei Wu, Hao Wang, Yujia Deng, Huali Xie, Ying Xia, Ming Lu
<p><b>Background</b> Olfactory mucosa mesenchymal stem cells (OM-MSCs) display significant clonogenicactivity and may be easily propagated for Parkinson's disease therapies. Methods of inducing OM-MSCs to differentiate into dopaminergic (DAergic) neurons using olfactory ensheathing cells (OECs) is thus an attractive topic of research.</p><p><b>Methods</b> We designed a hypoxic-induction protocol to generate DAergic neurons from OM-MSCs using a physiological oxygen (O2) level of 3% and OEC-conditioned medium (HI group)...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28315291/perspectives-of-stem-cell-based-therapy-for-age-related-retinal-degenerative-diseases
#5
Vladimir Holan, Barbora Hermankova, Jan Kossl
Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy and glaucoma, mostly affect the elderly population, and are the most common cause of decreased quality of vision or even blindness. So far, there is no satisfactory treatment protocol to prevent, stop or cure these disorders. A great hope and promise for patients suffering from retinal diseases is represented by stem cell-based therapy which could replace diseased or missing retinal cells, and support regeneration...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28315289/microrna-21-mediates-the-protective-effects-of-mesenchymal-stem-cells-derived-from-ipscs-to-human-bronchial-epithelial-cell-injury-under-hypoxia
#6
Cheng-Lin Li, Zhi-Bin Xu, Xing-Liang Fan, He-Xin Chen, Qiu-Ning Yu, Shu-Bin Fang, Shu-Yue Wang, Yong-Dong Lin, Qing-Ling Fu
Airway epithelial cell injury is a key triggering event to activate allergic airway inflammation, such as asthma. We previously reported that administration of mesenchymal stem cells significantly alleviated allergic inflammation in a mouse model of asthma, and the mmu-miR-21/ACVR2A axis may be involved. However, whether MSCs protect against bronchial epithelial cell injury induced by hypoxia and the underlying mechanism remain unknown. In our study, the human bronchial epithelial cell line BEAS-2B was induced to undergo apoptosis with a hypoxia mimic of CoCl2 damage...
March 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28281438/engineered-microvasculature-in-pdms-networks-using-endothelial-cells-derived-from-human-induced-pluripotent-stem-cells
#7
Amogh Sivarapatna, Mahboobe Ghaedi, Yang Xiao, Edward Han, Binod Aryal, Jing Zhou, Carlos Fernandez-Hernando, Yibing Qyang, Karen K Hirschi, Laura E Niklason
In this study, we used a PDMS-based platform for the generation of intact, perfusioncompetent microvessel networks <i>in vitro</i>. COMSOL Multiphysics, a finite element analysis and simulation software package, was used to obtain simulated velocity, pressure, and shear stress profiles. Transgene-free human iPSCs were differentiated into partially arterialized endothelial cells (hiPSC-ECs) in 5 days under completely chemically defined conditions, using the small molecule GSK3β inhibitor CHIR99021 and thoroughly characterized for functionality and arteriallike marker expression...
March 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28258666/the-role-of-gene-editing-in-neurodegenerative-diseases
#8
Hueng-Chuen Fan, Ching-Shiang Chi, Yih-Jing Lee, Jeng-Dau Tsai, Shinn-Zong Lin, Horng-Jyh Harn
Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and Parkinson's diseases, have become the most dreaded maladies because of no precise diagnostic tools or definite treatments for these debilitating diseases. The increased prevalence and a substantial impact on the social-economic and medical care of NDs propel governments to develop policies to counteract the impact. Although the etiologies of NDs are still unknown, growing evidence suggests that genetic, cellular and circuit alternations may cause the generation of abnormal misfolded proteins, which uncontrolledly accumulate to damage eventually overwhelms the protein-disposal mechanisms of these neurons, leading to a common pathological feature of NDs...
March 3, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28258665/ppar-%C3%AE-agonist-with-mesenchymal-stem-cells-induces-type-ii-collagen-producing-chondrocytes-in-human-arthritic-synovial-fluid
#9
Bruce E Heck, Joshua J Park, Vishruti Makani, Eun-Cheol Kim, Dong Hyun Kim
Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA and the population is expected to reach 67 million in USA by 2030. Thus, it is urgent to find an effective OA treatment. Traditional OA treatments have no disease-modifying effect while regenerative OA therapies such as autologous chondrocyte implantation (ACI) show some promise. Nonetheless, current regenerative therapies do not overcome synovial inflammation that suppresses the differentiation of mesenchymal stem cells (MSCs) to chondrocytes and the expression of type II collagen, the major constituent of functional cartilage...
March 3, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28332468/regenerative-medicine-shedding-light-into-the-link-between-aging-and-cancer
#10
Fabio Marongiu, Maria Paola Serra, Maura Fanti, Erika Cadoni, Monica Serra, Ezio Laconi
The evidence linking aging and cancer is overwhelming. Findings emerging from the field of regenerative medicine reinforce the notion that aging and cancer are profoundly interrelated in their pathogenetic pathways. We discuss evidence to indicate that age-associated alterations in the tissue microenvironment contribute to the emergence of a neoplastic-prone tissue landscape, which is able to support the selective growth of pre-neoplastic cell populations. Interestingly, tissue contexts that are able to select for the growth of pre-neoplastic cells, including the aged liver microenvironment, are also supportive for the clonal expansion of normal, homotypic, transplanted cells...
March 2, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28213959/combining-induced-pluripotent-stem-cells-and-genome-editing-technologies-for-clinical-applications
#11
Chia-Yu Chang, Hsiao-Chien Ting, Hong-Lin Su, Jing-Ren Jeng
In this review, we introduce current developments in induced pluripotent stem cells (iPSCs), site-specific nuclease (SSN)-mediated genome editing tools, and the combined application of these two novel technologies in biomedical research and therapeutic trials. The sustainable pluripotent property of iPSCs in vitro not only provides unlimited cell sources for basic research but also benefits precision medicines for human diseases. In addition, rapidly evolving SSN tools efficiently tailor genetic manipulations for exploring gene functions and can be utilized to correct genetic defects of congenital diseases in the near future...
February 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28195036/gsk-3%C3%AE-inhibition-induced-neuroprotection-regeneration-and-functional-recovery-after-intracerebral-hemorrhagic-stroke
#12
Yingying Zhao, Zheng Zachory Wei, James Ya Zhang, Yongbo Zhang, Soonmi Won, Jinmei Sun, Shan Ping Yu, Jimei Li, Ling Wei
Hemorrhagic stroke is a devastating disease that lacks effective therapies. In the present investigation, we tested 6-bromoindirubin-3'-oxime (BIO) as a selective glycogen synthase kinase-3β (GSK-3β) inhibitor in a mouse model of intracerebral hemorrhage (ICH). ICH was induced by injection of collagenase IV into the striatum of 8 to 10-week old C57BL/6 mice. BIO (8 µg/kg, i.p.) was administered following either an acute delivery (0 - 2 hr delay) or a prolonged regimen (every 48 hrs starting at 3 days postICH)...
February 14, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28195035/pre-s2-mutant-induced-mammalian-target-of-rapamycin-signal-pathways-as-potential-therapeutic-targets-for-hepatitis-b-virus-associated-hepatocellular-carcinoma
#13
Chiao-Fang Teng, Han-Chieh Wu, Woei-Cherng Shyu, Long-Bin Jeng, Ih-Jen Su
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). Pre-S2 mutant represents an HBV oncoprotein that is accumulated in the endoplasmic reticulum (ER) and manifests as type II ground glass hepatocytes (GGHs). Pre-S2 mutant can induce ER stress and initiate multiple ER stress-dependent or -independent cellular signal pathways, leading to growth advantage of type II GGH. Importantly, the mammalian target of rapamycin (mTOR) signal pathways are consistently activated throughout the liver tumorigenesis in pre-S2 mutant transgenic mice and in human HCC tissues, leading to hepatocyte proliferation, metabolic disorders, and HCC tumorigenesis...
February 14, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28195034/treatment-of-spinocerebellar-ataxia-with-mesenchymal-stem-cells-a-phase-i-iia-clinical-study
#14
Yun-An Tsai, Ren-Shyan Liu, Jiing-Feng Lirng, Bang-Hung Yang, Chin-Hao Chang, YiChen Wang, Yu-Shan Wu, Jennifer Hui-Chun Ho, Oscar K Lee, Bing-Wen Soong
Ataxia is one of the most devastating symptoms of many neurodegenerative disorders. As of today, there isn’tany effective treatment to retard its progression. Mesenchymal stem cells (MSCs) have shown promise in treating neurodegenerative diseases. We hereby report the results of a phase I/IIa clinical study conducted in Taiwan to primarily evaluate the safety, tolerability and, secondarily, the possible efficacy of intravenous administration of allogeneic adipose tissuederived MSCs from healthy donors...
February 14, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28185615/clinical-study-of-neuroregen-scaffold-combined-with-human-mesenchymal-stem-cells-for-the-repair-of-chronic-complete-spinal-cord-injury
#15
Yannan Zhao, Fengwu Tang, Guang Han, Nuo Wang, Na Yin, Bing Chen, Xianfeng Jiang, Chen Yun, Wanjun Han, Changyu Zhao, Shixiang Cheng, Zhifeng Xiao, Sai Zhang, Jianwu Dai
Regeneration of damaged neurons and recovery of sensation and motor function after complete spinal cord injury (SCI) are challenging. We previously developed a collagen scaffold, NeuroRegen scaffold, to promote axonal growth along collagen fibers and inhibit glial scar formation after SCI. When functionalized with multiple biomolecules, this scaffold promoted neurological regeneration and functional recovery in animals with SCI. In this study, eight patients with chronic complete SCI were enrolled to examine the safety and efficacy of implanting NeuroRegen scaffold with human umbilical cord mesenchymal stem cells (MSCs)...
February 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28185610/hydrogen-sulfide-reduces-recruitment-of-cd11b-gr-1-cells-in-mice-with-myocardial-infarction
#16
Ting Wu, Hua Li, Bing Wu, Lei Zhang, San-Wu Wu, Jia-Ning Wang, You-En Zhang
The present study aimed to elucidate the mechanisms by which hydrogen sulfide (H<sub>2</sub>S) attenuates left ventricular remodeling after MI. Myocardial infarction was created in mice by left coronary artery ligation. One group of mice received injections of the H<sub>2</sub>S donor sodium hydrosulfide (NaSH) immediately before and one hour after ligation, while the control group received saline alone. During both the subacute and chronic stages (1 and 4 weeks post-infarction, respectively), NaHS-treated mice demonstrated attenuation of cardiac dilation in the infarcted myocardium...
February 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28185609/olfactory-ensheathing-cells-inhibit-gliosis-in-retinal-degeneration-by-down-regulation-of-the-m%C3%A3-ller-cell-notch-signaling-pathway
#17
Jing Xie, Shujia Huo, Yijian Li, Jiaman Dai, Haiwei Xu, Zheng Qin Yin
Retinal regeneration and self-repair, whether in response to injury or degenerative disease, are severely impeded by glial scar formation by Müller cells (specialized retinal macroglia). We have previously demonstrated that the activation of Müller cells and gliosis in the degenerative retina are significantly suppressed by the subretinal transplantation of a mixture of olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts. However, the underlying molecular mechanism has remained elusive. Here, we transplanted purified rat OECs into the subretinal space of pigmented Royal College of Surgeons (RCS) rats, a classic rodent model of retinal degeneration...
February 9, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28160460/the-timing-of-immunomodulation-induced-by-mesenchymal-stromal-cells-determines-the-outcome-of-the-graft-in-experimental-renal-allotransplantation
#18
Ana Merino, Elia Ripoll, Laura de Ramon, Nuria Bolaños, Montserrat Goma, Oriol Bestard, Nuria Lloberas, Josep M Grinyo, Juan Torras
<p>The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the effect of the donor-type MSCs from Wistar rats firstly on the immune system of immunocompetent Lewis rats and secondly the rejection responses in a renal transplantation model of Wistar to Lewis.</p><p>In the first experimental model, MSCs from bone marrow induced a systemic immune response in the immunocompetent Lewis rats, characterized by two different phases...
February 3, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28155818/fate-of-neural-progenitor-cells-transplanted-into-jaundiced-and-non-jaundiced-rat-brains
#19
Fu-Chen Yang, Sean M Riordan, Michelle Winter, Li Gan, Peter G Smith, Jay L Vivian, Steven M Shapiro, John A Stanford
High levels of bilirubin in infants can cause kernicterus, which includes basal ganglia damage and dystonia. Stem celltransplantation may be an effective treatment for this disease. In this study we transplanted human neural progenitor cells differentiated toward propriospinal interneurons into the striatum of 20-day old spontaneously jaundiced (jj) Gunn rats and nonjaundiced (Nj) littermates. Using immunohistochemical methods, we found that grafted cells survived and grew fibers in jj and Nj brains 3 weeks after transplantation...
February 3, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28155815/pig-to-primate-islet-xenotransplantation-past-present-and-future
#20
Zhengzhao Liu, Wenbao Hu, Tian He, Yifan Dai, Hidetaka Hara, Rita Bottino, David K C Cooper, Zhiming Cai, Lisha Mou
Islet allotransplantation results in increasing success in treating type 1 diabetes, but the shortage of deceased humandonor pancreata limits progress. Islet xenotransplantation, using pigs as sources of islet is a promising approach to overcome this limitation. The greatest obstacle is the primate immune/ inflammatory response to the pig islets, which may take the form of rapid early graft destruction (the instant blood-mediated inflammatory reaction) or T cell-mediated rejection. These problems are being resolved by the genetic engineering of the source pigs combined with improved immunosuppressive therapy...
February 3, 2017: Cell Transplantation
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