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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/29786890/thrombotic-and-hemorrhagic-complications-during-visceral-transplantation-risk-factors-and-association-with-intraoperative-disseminated-intravascular-coagulation-like-thromboelastographic-qualities-single-center-retrospective-study
#1
Yehuda Raveh, Yiliam Rodriguez, Ernesto Pretto, Fouad Souki, Vadim Shatz, Behrouz Ashrafi, Vinaya Manmohansigh, Michael Demos, Joshua Livingstone, Georges Nasrallah, David Andrews, Thiago Beduschi, Rodrigo Vianna, Ramona Nicolau-Raducu
This study describes the risk of thrombotic and hemorrhagic complications, both intraoperatively, and up to 1-month following visceral transplantation. Data from 48 adult visceral transplants performed between 2010-2017 were retrospectively studied (32 multivisceral (MVTx); 10 isolated intestine; 6 modified-MVTx). Intraoperatively, intracardiac thrombosis (ICT)/pulmonary embolism (PE) occurred in 25%, 0% and 0% of MVTx, isolated intestine and modified MVTx, respectively, and was associated with 50% (4/8) mortality...
May 22, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29772613/safety-of-dual-kidney-transplantation-compared-to-single-kidney-transplantation-from-expanded-criteria-donors-a-single-center-cohort-of-39-recipients
#2
Lionel Mendel, Laetitia Albano, Imad Bentellis, Thierry Yandza, Caroline Bernardi, Herve Quintens, Brannwel Tibi, Jacques Jourdan, Matthieu Durand, Jean Amiel, Daniel Chevallier
Our objective was to compare outcomes of DKT to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analyzed. DKT were indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23...
May 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29763973/impact-of-changing-the-recruitment-and-interview-procedures-for-cornea-donation-on-the-consent-rate-at-a-university-hospital-in-switzerland
#3
LETTER
Mathias Nebiker, Beatrice E Frueh, Christoph Tappeiner
We analyzed the impact of implementing a new concept for obtaining the consent for corneal donation on donor rates at our university hospital. This study emphasizes the potential of process improvements to overcome the shortage of corneal donor tissue and should encourage other clinics in such efforts. In Switzerland, organ and tissue donation is regulated by the national transplantation law, i.e. recovery of organs and/or tissue is only allowed if according consent has been given by the deceased person during lifetime...
May 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29763963/medication-tradeoffs-not-all-noncompliance-is-what-it-seems
#4
Greg J McKenna
Admit it. More than once, you've scanned a transplant journal, searching for a novel topic, something different from the many ubiquitous registry reviews. You hope you can find something topical, relevant for your patients and timely to current events. You probably didn't even realize this issue of Transplant International would be the one containing that very tropical, relevant and timely manuscript. This article is protected by copyright. All rights reserved.
May 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29761901/the-fear-for-contrast-induced-nephropathy-in-kidney-transplant-recipients-time-for-a-paradigm-shift
#5
LETTER
Stan Benjamens, Derya Yakar, Riemer H J A Slart, Jan-Stephan F Sanders, Robert A Pol
A recently published article in the Lancet (AMACING trial) challenges a long-standing clinical consensus: intravenous (i.v.) volume expansion with isotonic saline as a prophylactic measure for iodinated contrast-induced nephropathy (CIN) [1]. The randomized trial showed that - in patients with an estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73m², undergoing an elective procedure - as compared to i.v. hydration, no prophylaxis is non-inferior in preventing CIN. This article is protected by copyright...
May 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29722117/upregulation-of-cd80-on-glomerular-podocytes-plays-an-important-role-in-development-of-proteinuria-following-pig-to-baboon-xeno-renal-transplantation-an-experimental-study
#6
Christopher J Rivard, Tatsu Tanabe, Miguel A Lanaspa, Hironosuke Watanabe, Shunichiro Nomura, Ana Andres-Hernando, Krystle Garth, Mitsuhiro Sekijima, Takuji Ishimoto, Yuichi Ariyoshi, Gabriela E Garcia, Jigesh Shah, Lennan Boyd, Masayuki Tasaki, Thomas Pomposelli, Akira Shimizu, David H Sachs, Richard J Johnson, Kazuhiko Yamada
We have previously reported that co-transplantation of the kidney with vascularized donor thymus from α-1, 3-galactosyl transferase gene knockout pigs, with an anti-CD154 with rituximab-based regimen led to improved xenograft survival in baboons with donor-specific unresponsiveness. However, nephrotic syndrome emerged as a complication in which the glomeruli showed mild mesangial expansion with similarities to minimal change disease (MCD) in humans. Since MCD is associated with CD80 expression in glomeruli and elevated urinary excretion, we evaluated a potential role for CD80 in xenograft nephropathy...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29722081/liver-alone-or-simultaneous-liver-kidney-transplant-pre-transplant-chronic-kidney-disease-and-post-transplant-outcome-a-retrospective-study
#7
Shunji Nagai, Mohamed Safwan, Kelly Collins, Randolph E Schilke, Michael Rizzari, Dilip Moonka, Kimberly Brown, Anita Patel, Atsushi Yoshida, Marwan Abouljoud
The new Organ Procurement and Transplant Network/United Organ Sharing Network (OPTN/UNOS) simultaneous liver-kidney transplant (SLK) policy has been implemented. The aim of this study was to review liver transplant outcomes utilizing the new SLK policy. Liver transplant alone (LTA) and SLK patients between 2009 and 2015 were reviewed. Graft survival and post-transplant kidney function were investigated among LTA patients meeting the chronic kidney disease (CKD) criteria of the new policy (LTA-CKD group). In order to validate our findings, we reviewed and applied our analysis to the OPTN/UNOS registry...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29722077/anril-as-a-genetic-marker-for-cardiovascular-events-in-renal-transplant-patients-an-observational-follow-up-cohort-study
#8
A Arbiol-Roca, A Padró-Miquel, A Vidal-Alabró, M Hueso, P Fontova, O Bestard, I Rama, J Torras, J M Grinyó, P Alía-Ramos, J M Cruzado, N Lloberas
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in kidney transplant recipients. Several single nucleotide polymorphisms (SNPs) in the ANRIL gene pathway have been associated with cardiovascular events (CE). The main objective was to ascertain whether ANRIL (rs10757278) and CARD8 (rs2043211) SNPs could mediate susceptibility to CE. METHODS: This was an observational follow-up cohort study of renal transplant recipients at Bellvitge University Hospital (Barcelona) from 2000-2014...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29722074/analysis-of-caudate-lobe-biliary-anatomy-and-its-implications-in-living-donor-liver-transplantation-a-single-centre-prospective-study
#9
Kausar Makki, Vishal Chorasiya, Ajitabh Srivastava, Ashish Singhal, Arif Ali Khan, Vivek Vij
Biliary complications are a significant cause of morbidity after living donor liver transplant (LDLT). Bile leak may occur from bile duct (anastomotic site in recipient and repaired bile duct stump in donor), cystic duct stump, cut surface pedicles or from divided caudate ducts. The first three sites are amenable to post-operative endoscopic stenting as they are in continuation with biliary ductal system. However, leaks from divided isolated caudate ducts can be stubborn. To minimize caudate duct bile leaks, it is important to understand the anatomy of hilum with attention to the caudate lobe biliary drainage...
May 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29710433/remnant-vital-tissue-following-locoregional-therapy-for-hepatocellular-carcinoma-another-player-in-the-game
#10
Angel Rubin, Marina Berenguer
The applicability of liver transplantation (LT) as a curative option for patients with hepatocellular carcinoma (HCC) is limited by organ shortage. In addition to tumor size and number, other variables, particularly those that are surrogates of tumor biology should be incorporated into the allocation policies to improve the estimation of post-LT benefit. In this issue of Transplant International, Manzia et al. analyze the role of remnant vital tissue (RVT) of the target lesion after locoregional therapies (LRT) in predicting post-LT HCC recurrence This article is protected by copyright...
April 30, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29687486/artificial-intelligence-improves-estimation-of-tacrolimus-area-under-the-concentration-over-time-curve-in-renal-transplant-recipients
#11
LETTER
Olivier Niel, Paul Bastard
It has been shown that renal graft survival largely depends on the type and dosing of immunosuppressant treatments [1]. Tacrolimus, a widely-used calcineurin inhibitor, has a narrow therapeutic window, which makes regular drug monitoring necessary [2]. Interestingly, area-under-the-concentration over time curve (AUC) correlates better with clinical complications, such as nephrotoxicity [3], infections and acute rejection, compared to trough levels. This article is protected by copyright. All rights reserved...
April 24, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29687492/-safety-of-hepatitis-c-virus-hcv-treated-donors-for-kidney-transplantation-kt-excluding-occult-hcv-infection-through-kidney-biopsies
#12
LETTER
Rosana Gelpi, Camino Rodríguez-Villar, David Paredes, Rebeca Roque, Angel Ruiz, Ramon Adalia, Erika De Sousa, Ignacio Revuelta, Manuel Sole, Miguel Martinez, M Navarro, Sabela Lens, Federico Oppenheimer, Fritz Diekmann
In 2011, the first Direct Acting Antiviral (DAA) agent was approved for HCV treatment, with high rates of sustained viral response (SVR). Absence of RNA-HCV viral load 12 weeks after end of treatment is considered as permanent viral eradication. However anti-HCV could remain positive despite successful antiviral therapy2.Moreover,HCV can infect extrahepatic tissues, including kidney. The infected extrahepatic tissues might play a role in both HCV persistence and reactivation of infection. This article is protected by copyright...
April 23, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29676803/outcome-of-the-risk-stratified-desensitization-protocol-in-donor-specific-antibody-positive-living-kidney-transplant-recipients-a-retrospective-study
#13
Daigo Okada, Masayoshi Okumi, Yoichi Kakuta, Kohei Unagami, Junpei Iizuka, Toshio Takagi, Hideki Ishida, Kazunari Tanabe
Acceptable outcomes of donor-specific antibody (DSA)-positive living kidney transplantation (LKT) have recently been reported. However, LKT in crossmatch (XM)-positive patients remains at high-risk and requires an optimal desensitization protocol. We report our intermediate-term outcomes of XM-positive LKT versus XM-negative LKT in patients who underwent LKT between January 2012 and June 2015 in our institution. The rate of acute antibody-mediated rejection (ABMR) within 90 days post-operation, graft function, and patient and graft survival rates at 4 years were investigated...
April 20, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29672993/intra-operative-cell-salvage-and-sickle-cell-trait-in-liver-transplantation-time-to-re-consider
#14
LETTER
P S Loh, F Gilder, J Klinck
Sickle cell trait (SCT), characterized by the sickle hemoglobin (HbS) gene in a heterozygous state is the most common hemoglobinopathy worldwide that is typically asymptomatic in affected individuals [1]. In Europe, migration has increased the prevalence, raising concerns about its clinical impact [1]. For example, the use of intraoperative cell salvage may induce sickling because of hypoxia during processing [2]. This article is protected by copyright. All rights reserved.
April 19, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29665191/the-impact-of-donor-body-mass-index-on-outcomes-after-deceased-kidney-transplantation
#15
Adam Arshad, James Hodson, Imogen Chappelow, Nicholas G Inston, Andrew R Ready, Jay Nath, Adnan Sharif
The aim of this study was to determine the effect of donor body mass index (BMI) on deceased-donor kidney transplant outcomes. Data were collected from the UK Transplant Registry for all deceased-donor kidney transplant recipients between January 2003 and January 2015. Univariable and multivariable analyses were undertaken to assess the impact of donor BMI on a range of outcomes. Donor BMI (kg/m2 ) was stratified as <18.5 (n=380), 18.5-25.0 (n=6890), 25.1-30.0 (n=6669), 30.1-35.0 (n=2503) and >35.0 (n=1148)...
April 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29665164/elderly-kidney-donors-better-than-their-reputation-but-where-are-the-limits
#16
Thomas Fehr
Kidney allograft from elderly donors bear higher peri- and posttransplant risks, such as delayed graft function with or without need for dialysis, lower allograft function at the early phase and shorter allograft survival. In contrast, allografts from younger donors perform better - in young and old recipients. Thus, in a perfect world without organ shortage, allograft from younger donors would be preferred irrespective of the recipient's age. So far, the maths is simple. This article is protected by copyright...
April 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29665090/lung-allocation-score-the-eurotransplant-model-vs-the-revised-u-s-model
#17
Jacqueline M Smits, George Nossent, Patrick Evrard, György Lang, Christiane Knoop, Johanna M Kwakkel-van Erp, Frank Langer, Rene Schramm, E D van de Graaf, Robin Vos, Geert Verleden, Benoit Rondelet, Daniel Hoefer, Rogier Hoek, Konrad Hoetzenecker, Tobias Deuse, Agita Strelniece, Dave Green, Erwin de Vries, Undine Samuel, Guenther Laufer, Roland Buhl, Christian Witt, Jens Gottlieb
AIM: Both Eurotransplant (ET) and the US use the Lung Allocation Score (LAS) to allocate donor lungs. In 2015, the US implemented a new algorithm for calculating the score while ET has fine tuned the original model by using business rules. A comparison of both models in a contemporary patient cohort was performed. PATIENTS AND METHODS: The rank positions and the correlation between both scores were calculated for all patients on the active waiting list in ET. RESULTS: On February 6th 2017, 581 patients were actively listed on the lung transplant waiting list...
April 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29611277/renal-transplantation-outcome-and-social-deprivation-in-the-french-healthcare-system-a-cohort-study-using-the-european-deprivation-index
#18
Valérie Châtelet, Sahar Bayat-Makoei, Cécile Vigneau, Guy Launoy, Thierry Lobbedez
The study objective was to estimate the effect of social deprivation estimated by the European Deprivation Index (EDI) on the risk of death and graft failure on renal transplantation in France. EDI was calculated for 8701 of 9205 patients receiving a first renal transplantation between 2010 and 2014. Patients were separated in EDI quintiles of the general population. A Cox model (cs-HR: cause-specific hazard ratio of death or graft failure) and a Fine and Gray model (sd-HR: subdistribution hazard ratio of death and graft failure) were used for the analysis...
April 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29611220/cardiovascular-disease-after-transplantation-an-emerging-role-of-the-immune-system
#19
REVIEW
S Van Laecke, T Malfait, E Schepers, W Van Biesen
Cardiovascular disease after transplantation: an emerging role of the immune system. Cardiovascular disease after transplantation remains a major concern. Little is known about what drives the increased cardiovascular risk in transplant recipients apart from traditional risk factors. The immune system is involved in the pathogenesis of hypertension, atherosclerosis, and coronary artery disease in the general population. Recently, inhibition of interleukin 1-β by canakinumab versus placebo decreased the incidence of cardiovascular events...
April 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29603453/prognosis-of-psc-time-to-look-at-the-population-as-a-whole-not-only-from-the-center-s-or-waiting-list-perspective
#20
Wolf Bechstein, Andreas Schnitzbauer
Equitable and fair allocation of liver grafts remains a challenge in transplantation of organs from deceased donors. Both the prognosis with and without transplantation should to be reliably assessed when deciding which patient should be preferred during the allocation process. In this issue of the journal, Goet et al. present their analysis of the current policy regarding allocation of donor livers for patients with primary sclerosing cholangitis (PSC) in the Netherlands (NL) who were entered unto the Eurotransplant (ET) waiting list during a 7 year period from December 2006 through December 2013...
March 30, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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