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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/28102906/filling-the-gap-between-clinical-trials-and-real-life-in-the-treatment-of-severe-hcv-recurrence-after-liver-transplantation
#1
Patrizia Burra, Alberto Zanetto
In this issue of Transplant International, Herzer et al. report the results obtained in a real-world European cohort of 87 patients with severe recurrent hepatitis C (HCV) after liver transplantation (LT), who were treated with a compassionate use of daclatasvir (DCV) plus registered sofosbuvir (SOF), with or without ribavirin (RBV). The vast majority of patients were HCV genotype 1, though the sample included a few with genotypes 3 and 4. It is noteworthy that 37/87 patients (42.5%) had cirrhosis (and 16/37 patients [43%] had Child-Pugh B/C decompensated cirrhosis)...
January 19, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28095640/irradiation-before-and-donor-splenocyte-infusion-immediately-after-transplantation-induce-tolerance-to-lung-but-not-heart-allografts-in-miniature-swine
#2
Wiebke Sommer, Gwen Buechler, Katharina Jansson, Murat Avsar, Ann-Kathrin Knöfel, Jawad Salman, Klaus Hoeffler, Thierry Siemeni, Jens Gottlieb, Johann H Karstens, Danny Jonigk, Ansgar Reising, Axel Haverich, Martin Strüber, Gregor Warnecke
Solid organs may differ in their potential to induce and maintain a state of donor-specific tolerance. Previously, we induced stable immunological tolerance in a lung transplantation model in miniature swine. Here, we wished to transfer this established protocol into a heart transplantation model in miniature swine. Heterotopic heart transplantation (HTX) was performed in four, and left-sided lung transplantation (LTX) in seven minipigs from gender and SLA mismatched donors. All recipients received non-myeloablative irradiation, donor splenocyte infusion and intravenous pharmacologic immunosuppression for 28 postoperative days...
January 17, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28078769/interleukin-1%C3%AE-induced-release-of-interleukin-8-by-human-bronchial-epithelial-cells-in-vitro-assessing-mechanisms-and-possible-treatment-options
#3
REVIEW
Hannelore Bellon, Elly Vandermeulen, Carolien Mathyssen, Annelore Sacreas, Stijn E Verleden, Tobias Heigl, Hanne Vriens, Elise Lammertyn, Charles Pilette, Peter Hoet, Robin Vos, Bart M Vanaudenaerde, Geert M Verleden
BACKGROUND: Survival after lung transplantation is hampered by chronic lung allograft dysfunction (CLAD). Persistently elevated BAL-neutrophilia is observed in some patients despite treatment with azithromycin, which may be induced by IL-1α. Our aim is to establish an in vitro model, assess mechanistic pathways and test different therapeutic strategies of IL-1α induced release of IL-8 by human bronchial epithelial cells. METHODS: Bronchial epithelial cells (16HBE) were stimulated with IL-1α with or without azithromycin or dexamethasone...
January 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28058795/transplant-size-mismatch-in-restrictive-lung-disease
#4
Asvin M Ganapathi, Michael S Mulvihill, Brian R Englum, Paul J Speicher, Brian C Gulack, Asishana A Osho, Babatunde A Yerokun, Laurie R Snyder, Duane Davis, Matthew G Hartwig
BACKGROUND: To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. METHODS: All single and bilateral RLD lung transplants from 1987-2011 in the UNOS Database were identified. Donor pTLC:Recipient pTLC ratio (pTLCr), quantified mismatch. pTLCr was segregated into 5 strata. A Cox proportional hazards model evaluated the association of pTLCr with mortality hazard...
January 6, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28058737/liver-transplantation-with-geriatric-liver-allografts-the-current-situation-in-eurotransplant
#5
LETTER
Jacob D de Boer, Jacob J E Koopman, Herold J Metselaar, Andries E Braat, Joris J Blok
In light of the donor organ shortage and the high number of liver transplantation (LT) candidates on the waiting list, the number of extended criteria donors (ECD) increased over time. Among the criteria defining an ECD, donor age is stretched most, so that the use of septuagenarian, octogenarian and even nonagenarian donors increasingly became common practice (1,2). This article is protected by copyright. All rights reserved.
January 6, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28032376/evaluation-of-hla-sensitization-in-burn-patients-after-treatment-with-skin-allografts-and-transfusion-of-blood-products
#6
LETTER
Andrew J Lindford, Jouni Lauronen, Eeva Juvonen, Katri Haimila, Virve Koljonen
Treatment for extensive burns may sensitize patients to antibodies specific for human leukocyte antigens (HLA), thus endangering their eligibility for organ and vascularized composite allotransplantation (VCA) recipients. Blood transfusions and allograft skin use are the most common reasons for HLA sensitization in burn patients [1]. The risk of forming alloantibodies against donor red blood cell (RBC) antigens is most likely linked to the number of transfusions [2], genetic predisposition and immune response [3]...
December 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28012226/treg-therapy-in-transplantation-a-general-overview
#7
REVIEW
Marco Romano, Sim Lai Tung, Lesley Ann Smyth, Giovanna Lombardi
Solid organ transplantation remains the treatment of choice for end-stage organ failure. Whilst the short term outcomes post-transplant have improved in the last decades, chronic rejection and immunosuppressant side effects remain an ongoing concern. Hematopoietic stem cell transplantation is a well-established procedure for the treatment of patients with haematological disorders. However, donor T-cells are continually primed and activated to react against the host causing graft-versus-host-disease (GvHD) that leads to tissue damages and death...
December 24, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28012223/transplant-center-volume-and-outcomes-in-lung-transplantation-for-cystic-fibrosis
#8
Don Hayes, Stuart C Sweet, Christian Benden, Benjamin T Kopp, Samuel B Goldfarb, Gary A Visner, George B Mallory, Joseph D Tobias, Dmitry Tumin
INTRODUCTION: Transplant volume represents lung transplant (LTx) expertise and predicts outcomes, so we sought to determine outcomes related to center volumes in CF. METHODS: United Network for Organ Sharing data were queried for CF patients receiving bilateral LTx from 2005-2015. Multivariable Cox regression was used to model survival to 1 year and long-term (>1 year) survival, conditional on surviving at least 1 year. RESULTS: 2,025 patients and 67 centers were included in the analysis...
December 24, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28012215/real-world-experience-with-daclatasvir-plus-sofosbuvir-%C3%A2-ribavirin-for-post-liver-transplant-hcv-recurrence-and-severe-liver-disease
#9
Kerstin Herzer, Tania M Welzel, Ulrich Spengler, Holger Hinrichsen, Hartwig Klinker, Thomas Berg, Peter Ferenci, Markus Peck-Radosavljevic, Akin Inderson, Yue Zhao, Maria Jesus Jimenez-Exposito, Stefan Zeuzem
Optimizing therapy of post-transplant HCV recurrence remains important, especially in advanced liver disease. We evaluated daclatasvir (DCV) plus sofosbuvir (SOF), with or without ribavirin (RBV), in patients with post-liver transplant recurrence in a real-world European cohort at high risk of decompensation or death within 12 months. Recommended treatment was DCV 60mg plus SOF 400mg once-daily for 24 weeks; RBV use/shorter treatment duration was at physicians' discretion. Patients (N=87) were 70% male, 93% white, and mostly infected with HCV genotypes 1b (48%), 1a (32%), or 3 (9%); 37 (43%) had cirrhosis (16 decompensated), five had fibrosing cholestatic hepatitis...
December 24, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28000288/the-impact-of-kidney-transplantation-on-insulin-sensitivity
#10
Morten B Jørgensen, Mads Hornum, Gerrit van Hall, Claus Bistrup, Jesper M Hansen, Elisabeth R Mathiesen, Bo Feldt-Rasmussen
OBJECTIVE: To investigate the impact of kidney transplantation (KTx) on insulin sensitivity affecting glucose metabolism. METHODS: Nine non-diabetic patients awaiting living donor KTx were examined prior to transplantation with an oral glucose tolerance test and a 3h hyperinsulinaemic euglycaemic clamp. The clamp was repeated six months after KTx. Nine age, gender and BMI matched individuals with normal kidney function served as controls. Endogenous glucose production and glucose disappearance rate (N=6) were measured in a subgroup of patients with corresponding controls...
December 21, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27992973/abdominal-organ-procurement-in-the-netherlands-an-analysis-of-quality-and-clinical-impact
#11
J D de Boer, W H Kopp, K Ooms-de Vries, B J J M Haase-Kromwijk, C Krikke, J de Jonge, L W E Van Heurn, A G Baranski, J A Van der Vliet, A E Braat
Between March 2012 and August 2013, 591 quality forms were filled out for abdominal organs in The Netherlands. In 133 cases (23%) there was a discrepancy between the evaluation from the procuring and transplanting surgeons. Injuries were seen in 148 (25%) organs of which 12 (2%) led to discarding of the organ; 1/133 (0.8%) livers, 5/38 (13%) pancreata and 6/420 (1.4%) kidneys (p<0.001). Higher donor BMI was a risk factor for procurement related injury in all organs (OR 1.06, p=0.011) and DCD donation in liver procurement (OR 2...
December 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27992962/c1q-binding-is-not-an-independent-risk-factor-for-kidney-allograft-loss-after-an-acute-antibody-mediated-rejection-episode-a-retrospective-cohort-study
#12
Anissa Moktefi, Juliette Parisot, Dominique Desvaux, Florence Canoui-Poitrine, Isabelle Brocheriou, Julie Peltier, Vincent Audard, Tomek Kofman, Caroline Suberbielle, Philippe Lang, Eric Rondeau, Philippe Grimbert, Marie Matignon
After kidney transplantation, C4d is an incomplete marker of acute antibody-mediated rejection (AMR) and C1q-binding donor-specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q binding impact on allograft survival. We compared clinical, histological, and serological features of C4d- and C4d+ AMR, C1q+ and C1q- DSA AMR and analysed C4d and C1q-binding impact on allograft survival...
December 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27987369/procurement-professionalization-a-mandatory-step-to-improve-the-availability-and-quality-of-whole-pancreas-grafts
#13
Axel Andres, Michela Assalino, Graziano Oldani, Christian Toso, Thierry Berney
The lack of available organs remains one of the main limitations in the field of solid organ transplantation. Most transplant organizations work on improving donation rate through public information programs, and by exploring new organ sources, such as Donors after Cardio-circulatory Death (DCD). This article is protected by copyright. All rights reserved.
December 17, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27957767/ethylene-carbodiimide-fixed-donor-splenocytes-combined-with-%C3%AE-1-antitrypsin-induce-indefinite-donor-specific-protection-to-mice-cardiac-allografts
#14
Xingqiang Lai, Longhui Qiu, Yi Zhao, Shuangjin Yu, Chang Wang, Jin Zhang, Fen Ning, Lizhong Chen, Guodong Chen
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate the effect of ECDI-SPs. Therefore, we hypothesized that blocking pro-inflammatory cytokine secretion while increasing levels of anti-inflammatory cytokines would enhance the tolerance-induced efficacy of ECDI-SPs. The objective of this study was to determine the effectiveness of using ECDI-SPs combined with a short course of α1-antitrysin (AAT) for induction of tolerance...
December 13, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896866/re-conceptualising-the-organ-trade-separating-trafficking-from-trade-and-the-implications-for-law-and-policy
#15
LETTER
Seán Columb, Frederike Ambagtsheer, Michael Bos, Ninoslav Ivanovski, Gregory Moorlock, Willem Weimar
The trade in human organs is considered a major international concern. In 2007 the World Health Organization (WHO) estimated that approximately 6000 kidney transplants are performed illegally each year (1). More recently, the Council of Europe declared that organ trade constitutes a "major threat to public health" and that it is growing worldwide due to the "greed of unscrupulous traffickers" (3). This article is protected by copyright. All rights reserved.
November 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896862/hcv-and-hev-recurrence-after-liver-transplantation-one-antiviral-therapy-for-two-viruses
#16
LETTER
Eleonora De Martin, Teresa M Antonini, Audrey Coilly, Gabriella Pittau, Eric Vibert, Jean-Charles Duclos-Vallée, Didier Samuel, Anne-Marie Roque-Afonso
No abstract text is available yet for this article.
November 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896858/efficacy-and-safety-of-simeprevir-and-sofosbuvir-with-and-without-ribavirin-in-subjects-with-recurrent-genotype-1-hepatitis-c-post-orthotopic-liver-transplant-the-randomized-galaxy-study
#17
Jacqueline G O'Leary, Robert J Fontana, Kimberly Brown, James R Burton, Roberto Firpi-Morell, Andrew Muir, Christopher O'Brien, Mordechai Rabinovitz, K Rajender Reddy, Robert Ryan, Adam Shprecher, Shirley Villadiego, Avinash Prabhakar, Robert S Brown
This prospective, randomized, phase 2 study in subjects with recurrent hepatitis C virus (HCV) genotype 1 post-orthotopic liver transplant evaluated once-daily simeprevir 150mg+sofosbuvir 400mg, with and without ribavirin 1,000mg. Primary endpoint was proportion of subjects with Week 12 sustained virologic response (SVR12). Thirty-three subjects without cirrhosis were randomized 1:1:1 into three arms (stratified by geno/subtype and Q80K): Arm 1, simeprevir+sofosbuvir+ribavirin, 12 weeks; Arm 2, simeprevir+sofosbuvir, 12 weeks; Arm 3, simeprevir+sofosbuvir, 24 weeks; 13 additional subjects (2 with cirrhosis, 11 without cirrhosis) entered Arm 3...
November 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896854/decreased-graft-survival-in-liver-transplant-recipients-of-donors-with-positive-blood-cultures-a-review-of-the-united-network-for-organ-sharing-dataset
#18
Moises A Huaman, Valery Vilchez, Xiaonan Mei, Malay B Shah, Michael F Daily, Jonathan Berger, Roberto Gedaly
Liver transplantation using blood culture positive donors (BCPD) has allowed a significant expansion of the donor pool. We aimed to characterize BCPD and assess the outcomes of BCPD liver transplant recipients. We retrieved data from the United Network for Organ Sharing (UNOS) registry on all adults who underwent primary, single-organ deceased-donor liver transplantation in the USA between 2008 and 2013. Patients were classified into two cohorts: the BCPD cohort and the non-BCPD cohort. One-year graft and patient survival were compared between cohorts using Kaplan-Meier estimates and Cox models...
November 29, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27896857/former-smoking-and-early-and-long-term-graft-outcome-in-renal-transplant-recipients-a-retrospective-cohort-study
#19
Steven Van Laecke, Evi Vanessa Nagler, Patrick Peeters, Francis Verbeke, Wim Van Biesen
Smoking is associated with unfavourable outcome in solid organ transplant recipients. Nicotine may predispose to kidney injury by increasing oxidative stress. We hypothesized that former smoking negatively affects graft outcome in kidney transplant recipients and especially those with delayed graft function (DGF). We included adult recipients of a kidney transplant between January 1(st) 2003 and October 1(st) 2015 at Ghent University Hospital and recorded outcomes until October, 31(st) 2015. We used Kaplan-Meier and multivariable Cox proportional hazard analysis to examine the relationship between former smoking at the time of transplantation and the incidence of 10-year graft loss with and without censoring for death in 1013 participants...
November 28, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27889929/twenty-eight-years-of-intestinal-transplantation-in-paris-experience-of-the-oldest-european-centre
#20
F Lacaille, S Irtan, L Dupic, C Talbotec, F Lesage, V Colomb, N Salvi, F Moulin, F Sauvat, Y Aigrain, Y Revillon, O Goulet, C Chardot
AIM: Our aim is to describe our achievements in pediatric intestinal transplantation (ITx) and define areas for improvement. METHODS: After a period (1987-90) of 9 isolated small bowel transplants (SBTx) where only one patient survived with her graft, 110 ITx were performed on 101 children from 1994 to 2014: 60 SBTx, 45 liver-small bowel, 4 multivisceral (3 with kidneys), 1 modified multivisceral. Indications were short bowel syndrome (36), motility disorders (30), congenital enteropathies (34) and others (1)...
November 27, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
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