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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/28436117/early-introduction-of-oral-paricalcitol-in-renal-transplant-recipients-an-open-label-randomized-study
#1
Hege Kampen Pihlstrøm, Franscesca Gatti, Clara Hammarström, Ivar Anders Eide, Monika Kasprzycka, Junbai Wang, Guttorm Haraldsen, My Hanna Sofia Svensson, Karsten Midtvedt, Geir Mjøen, Dag Olav Dahle, Anders Hartmann, Hallvard Holdaas
In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de-novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-centre, prospective, randomized, open-label trial investigating effects of paricalcitol 2μg/day added to standard care...
April 24, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28432714/high-human-cytomegalovirus-dnaemia-early-post-transplantation-associates-with-irreversible-and-progressive-loss-of-renal-function
#2
Wouter T Lollinga, Lilli Rurenga-Gard, Willem van Doesum, Rik van Bergen, Arjan Diepstra, Judith M Vonk, Annelies Riezebos-Brilman, Hgm Niesters, Willem J van Son, Jacob van den Born, Jan-Stephan Sanders
BACKGROUND: Transplant recipients are prone to viral infections, which could affect renal transplantation outcome. Our aim was to assess the effects of early human cytomegalovirus (CMV) DNAemia on transplant renal function. METHODS: 264 (age 50.9±13.5; male 55%) Renal transplantation recipients undergoing preemptive anti-CMV therapy were retrospectively categorized based on early (<3 months post-Tx) CMV peak viral load (PVL); PVL≤536, PVL536-6310 or PVL>6310 International Units/ml (IU/ml)...
April 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28419684/should-organs-from-hepatitis-c-virus-infected-donors-be-used-for-transplantation-in-the-era-of-daas
#3
Hideki Ohdan
Hepatitis C virus (HCV) infection has been demonstrated to deleteriously impact both patient and graft survival following non-hepatic organ transplantation [1, 2]. Interferon (IFN)-based therapies prior to non-hepatic transplant in HCV-infected patients improved their survival, however, tolerability and low cure rates practically limited those therapies [3]. In addition, due to the risk of allograft rejection, IFN-based therapy following non-hepatic solid organ transplant is not generally recommended. This article is protected by copyright...
April 18, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28419581/successful-kidney-transplantation-in-highly-sensitised-ultra-long-term-dialysis-patients
#4
LETTER
Jennifer A McCaughan, Aisling E Courtney
Achieving successful kidney transplantation for highly sensitised patients is a global challenge. These individuals face inequity of access to organs as a consequence of their HLA antibody status; this equates to a prolonged wait time on dialysis, a mounting burden of comorbidity and an increased risk of death [1-3]. Kidney allocation policies across the world aim to address this by prioritising highly sensitised patients for compatible kidney offers [4-6]. Despite this, those who wait the longest for a kidney transplant remain the most highly sensitised...
April 18, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28403575/comparison-of-two-equivalent-meld-scores-for-hepatocellular-carcinoma-patients-using-data-from-the-united-network-for-organ-sharing-liver-transplant-waiting-list-registry
#5
Sarah K Alver, Douglas J Lorenz, Kenneth Washburn, Michael R Marvin, Guy N Brock
Hepatocellular carcinoma (HCC) patients have been advantaged on the liver transplant waiting list within the United States, and a 6-month delay and exception point cap have recently been implemented to address this disparity. An alternative approach to prioritization is an HCC-specific scoring model such as the MELD Equivalent (MELDEQ ) and the mixed new deMELD. Using data on adult patients added to the UNOS waitlist between 9/30/2009 and 6/30/14, we compared projected dropout and transplant probabilities for HCC patients under these two models...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28403566/outcomes-and-risk-stratification-for-late-antibody-mediated-rejection-in-recipients-of-abo-incompatible-kidney-transplants
#6
Bonnie E Lonze, Sunjae Bae, Edward S Kraus, Mary J Holechek, Karen E King, Nada Alachkar, Fizza F Naqvi, Nabil N Dagher, Adnan Sharif, Niraj M Desai, Dorry L Segev, Robert A Montgomery
The required intensity of monitoring for antibody-mediated rejection (AMR) after of ABO-incompatible (ABOi) kidney transplantation is not clearly formulized. We retrospectively evaluated a single-center cohort of 115 ABO-incompatible (ABOi) kidney transplant recipients, of which 32% were also HLA-incompatible (ABOi/HLAi) with their donors. We used an adjusted negative binomial model to evaluate risk factors for late AMR. Using this model, we risk-stratified patients into high- and low-risk groups for the development of late AMR...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28403563/the-impact-of-infections-on-delisting-patients-from-the-liver-transplantation-waiting-list
#7
Louise J M Alferink, Rosalie C Oey, Bettina E Hansen, Wojciech G Polak, Henk R van Buuren, Robert A de Man, Carolina A M Schurink, Herold J Metselaar
BACKGROUND: Approximately 20% of the patients listed for liver transplantation die before transplantation can be accomplished. Understanding risk factors for waiting list mortality may help to improve survival and organ allocation. Infections are very common in patients with cirrhosis and are associated with significant morbidity and mortality. This study analysed the frequency and characteristics of infections in patients awaiting liver transplantation, identified risk factors for withdrawal from the waiting list and evaluated the impact of infections on the clinical outcome...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28403541/histopathological-evaluation-of-pretransplant-donor-biopsies-in-expanded-criteria-donors-with-high-kidney-donor-profile-index
#8
A Sánchez-Escuredo, A Sagasta, I Revuelta, L M Rodas, D Paredes, M Musquera, F Diekmann, J M Campistol, M Solé, F Oppenheimer
There is no consensus on the allocation of renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) is used without the need for pre-transplant donor biopsies (PTDB). We explored whether PTDB based on Remuzzi Score (RS) allows identification of those marginal kidneys in the highest calculated KDPI risk group (>91%) that appropriate for single transplantation. A retrospective study was conducted of 485 consecutive kidneys procured from a single center and transplanted if the RS was <4...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28403531/short-term-effects-of-extracorporeal-graft-rinse-versus-circulatory-graft-rinse-in-living-donor-liver-transplantation-a-prospective-randomized-controlled-trial
#9
Amr M Yassen, Waleed R Elsarraf, Mohamed A Elmorshedi, Mohamed Abdel Wahab, Tarek Salah, Ahmed M Sultan, Ahmed N Elghawalby, Mohamed M Elshobari, Mohamed Elsadany, Khaled Zalata, Usama Shiha
BACKGROUND: Living donor liver transplantation has shorter cold ischemia time, less preservative volume and lower metabolic load compared to transplantation from deceased donors. We investigated the impact of rinsing the graft contents into the systemic circulation on operative course and post-operative outcomes. PATIENTS AND METHODS: Donors had right hepatectomy and grafts were preserved with cold Histidine-Tryptophan-Ketoglutarate solution. On ending portal vein anastomosis, grafts were flushed by patient's portal blood; either through incompletely anastomosed hepatic vein (Extracorporeal Rinse group, EcRg, n=40) or into systemic circulation (Circulatory Rinse group, CRg, n=40)...
April 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28393403/-annular-pancreas-as-graft-for-pancreas-transplantation-technical-considerations-and-long-term-follow-up-of-two-successful-cases
#10
LETTER
Carlos Jiménez-Romero, Alejandro Manrique, Iago Justo
Annular pancreas consists of a band of pancreatic tissue that encircles the descending part of the duodenum with smooth continuation to the pancreatic head. About two-thirds of cases with annular pancreas remain asymptomatic for life [1], but several complications such as acute pancreatitis [2], duodenal stenosis, peptic ulceration, and chronic pancreatitis have been associated with this anomaly [3-5]. To our knowledge, only two pancreas transplants have been reported using grafts that showed annular pancreas, both with a short follow-up time (one and six months, respectively) [6,7]...
April 9, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28390094/early-experience-with-hypothermic-machine-perfusion-of-living-donor-kidneys
#11
Michael Moser, Nathan Ginther, Yigang Luo, Gavin Beck, Ronn Ginther, Marla Ewen, Rhianna Matsche-Neufeld, Ahmed Shoker, Grzegorz Sawicki
BACKGROUND: Although hypothermic machine perfusion (HMP) has been shown to be beneficial to deceased donor kidneys, the effect of HMP on Living Donor Kidneys (LDK) is unknown. LDK are subjected to minutes of normothermic ischemia at the time of recovery. METHODS: Comparison of 16 LDK preserved by HMP with 16 LDK preserved by static cold storage (SCS). Outcomes of interest are resistive indices (RI), both while on HMP and postoperatively, and creatinine clearance (CrCl)...
April 8, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28390074/use-of-donors-with-genitourinary-malignancies-for-liver-transplantation-a-calculated-risk
#12
LETTER
Daniele Pezzati, Davide Ghinolfi, Quirino Lai, Giulia Cirillo, Erion Rreka, Nicolò Roffi, Paola Carrai, Andrea Ringressi, Paolo De Simone, Franco Filipponi
Liver transplantation (LT) is standard of care for end-stage liver disease. Organ shortage still remains an unsolved problem and is leading the transplant community to find new strategies to increase the donors pool. Donors with genitourinary malignancies (GUM) detected at the moment of procurement have been recently considered with this intent although accurate balancing between the risks of donor-transmitted cancer (DTC) and recipient death while awaiting in the list is required. This article is protected by copyright...
April 8, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28390073/thoracic-muscle-cross-sectional-area-is-associated-with-hospital-length-of-stay-post-lung-transplantation-a-retrospective-cohort-study
#13
Dmitry Rozenberg, Sunita Mathur, Margaret Herridge, Roger Goldstein, Heidi Schmidt, Noori A Chowdhury, Polyana Mendes, Lianne G Singer
Low muscle mass is common in lung transplant (LTx) candidates, however, the clinical implications have not been well described. The study aims were to compare skeletal muscle mass in LTx candidates with controls using thoracic muscle cross-sectional area (CSA) from computed tomography and assess the association with pre- and post-transplant clinical outcomes. This was a retrospective, single centre cohort study of 527 LTx candidates (median age: 55 IQR [42-62] years; 54% male). Thoracic muscle CSA was compared to an age-and sex-matched control group...
April 8, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28390067/tubulointerstitial-expression-and-urinary-excretion-of-connective-tissue-growth-factor-3-months-after-renal-transplantation-predict-interstitial-fibrosis-and-tubular-atrophy-at-5-years-in-a-retrospective-cohort-analysis
#14
Thomas Vanhove, Hiroshi Kinashi, Tri Q Nguyen, Christoph Metalidis, Koen Poesen, Maarten Naesens, Evelyne Lerut, Roel Goldschmeding, Dirk R J Kuypers
BACKGROUND: Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis and urinary CTGF (CTGFu) levels correlate with the development of human allograft interstitial fibrosis. METHODS: We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation. At month 3 and year 1, CTGFu was measured using ELISA and biopsies were immunohistochemically stained for CTGF, with semiquantitative scoring of tubulointerstitial CTGF positive area (CTGFti)...
April 8, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28346714/discrepant-serological-assays-for-pneumococcus-in-renal-transplant-recipients
#15
Jay A Fishman, David N Iklé, Robert A Wilkinson
Vaccine immunoprotection for Streptococcus pneumoniae is mediated by opsonizing antibodies targeting serotype-specific capsular polysaccharides. Quantitative antibody levels (ELISA) and antibody-mediated opsonophagcytic assays (OPA) measure vaccine-induced protection; correlation of these assays in transplantation requires investigation. This study examines the laboratory assessment of antibody titers in vaccinated renal recipients. Streptococcus pneumoniae 19A is common in immunocompromised hosts and is represented in protein-conjugate vaccines (PCV) and polysaccharide vaccines (PSV)...
March 27, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28332729/transplantation-of-kidneys-from-hepatitis-c-positive-donors-into-hepatitis-c-virus-infected-recipients-followed-by-early-initiation-of-direct-acting-antiviral-therapy-a-single-center-retrospective-study
#16
Kalyan Ram Bhamidimarri, Marco Ladino, Fernando Pedraza, Giselle Guerra, Adela Mattiazzi, Linda Chen, Gaetano Ciancio, Warren Kupin, Paul Martin, George Burke, David Roth
The availability of direct acting antiviral agents (DAA) has transformed the treatment of hepatitis C virus (HCV) infection. The current study is a case series that reports the outcomes from a cohort of twenty-five HCV-infected ESRD patients who received a kidney from an anti-HCV-positive deceased organ donor followed by treatment with DAAs in the early post-transplant period. Time to transplantation and the efficacy of DAA therapy as measured by sustained viral response at 12 weeks were assessed. The median waiting time from original date of activation on the UNOS waiting list until transplantation was 427 days, however, the median time from entering the patient into UNet(sm) for a HCV positive offer until transplantation was only 58 days...
March 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28332726/antibiotic-prophylaxis-for-preventing-post-orthotopic-liver-transplant-tuberculosis-is-there-a-safe-alternative-to-isoniazid
#17
LETTER
Dino Sgarabotto, Silvano Fasolato, Fabrizio Vianello, Fabio Vittadello, Patrizia Boccagni, Alberto Ferrarese, Patrizia Burra, Paolo Angeli, Umberto Cillo
We read with interest the research paper by Yoo JW et al who studied the prevalence of TB in subjects who underwent hematopoietic stem cell (HSCT) and solid organ transplantation (SOT). [1] These authors also reported the effectiveness of isoniazid (INH) prophylaxis since the introduction of latent tuberculosis infection (LTBI) screening. This article is protected by copyright. All rights reserved.
March 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28326627/obituary-thomas-earl-starzl-the-father-of-transplantation-march-11-1926-march-4-2017-to-be-published-in-esot-newsletter-transplant-international
#18
Jan P Lerut
March 2016…the transplant community celebrated with pomp the 90(th) birthday of transplantation pioneer, Th. E. Starzl. More than 400 surgeons and scientists originating from all over the United States and from all five continents met in Pittsburgh to pay tribute to their mentor, teacher and friend. The 'Starzl family at large' experienced a once in a lifetime event ending with a thoughtful, but typical (Fig. 1) 'Starzl speech' about past and future, including a humoristic but realistic view on life and ageing...
March 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28319322/an-analysis-of-the-survival-outcomes-of-simultaneous-pancreas-and-kidney-transplantation-compared-to-live-donor-kidney-transplantation-in-patients-with-type-1-diabetes-a-uk-transplant-registry-study
#19
Adam D Barlow, Kourosh Saeb-Parsy, Christopher J E Watson
BACKGROUND: Transplant options for patients with type 1 diabetes and end-stage renal disease (ESRD) include deceased donor kidney, live donor kidney (LDK) and simultaneous pancreas-kidney (SPK) transplantation. The aim of this study was to compare outcomes between LDK and SPK for patients with type 1 diabetes and ESRD in the UK. METHODS: Data on all SPK (n=1739) and LDK (n=385) transplants performed between January 2001 and December 2014 were obtained from the UK Transplant Registry...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28319288/impact-of-single-centre-kidney-paired-donation-transplantation-to-increase-the-donor-pool-in-india
#20
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priyadarshini S Shah, Manisha P Modi, Beena P Butala, Pavan S Wakhare, Umesh T Varyani, Saiprasad G Shinde, Vijay A Ghodela, Govind S Kasat, Mayur V Patil, Jaideep C Patel, Deepk P Kumar, Varsha B Trivedi, Minaxi H Patel, Hargovind L Trivedi
In a living donor kidney transplantation (LDKT) dominated transplant programme, kidney paired donation (KPD) may be a cost-effective and valid alternative strategy to increase LDKT in countries with limited resources where deceased donation kidney transplantation (DDKT) is in the initial stages. Here, we report our experience of 300 single-centre KPD transplantations to increase LDKT in India. Between January 2000 and July 2016, 3616 LDKT and 561 DDKT were performed at our transplantation centre, 300 (8.3%) using KPD...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
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