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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/30198148/dynamics-of-early-post-operative-plasma-ddcfdna-levels-in-kidney-transplantation-a-single-centre-pilot-study
#1
Jia Shen, Yang Zhou, Yawen Chen, Xiaofeng Li, Wenhua Lei, Jun Ge, Wenhan Peng, Jianyong Wu, Guangjun Liu, Gongda Yang, Haifeng Shi, Jianghua Chen, Tingya Jiang, Rending Wang
Donor derived cell free DNA (ddcfDNA) is reported to be a promising noninvasive biomarker for acute rejection in organ transplant. However, studies on monitoring ddcfDNA dynamics during the early periods after organ transplantation are scarce. Our study assessed the dynamic variation of ddcfDNA in early period with various types and status of kidney transplantation. Target region capture sequencing used identifies ddcfDNA level in 21 kidney transplant recipients. Median ddcfDNA level was 20.69% at the initial time post-transplant, and decreased to 5...
September 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30198069/dual-aortic-and-portal-perfusion-at-procurement-prevents-ischemic-type-biliary-lesions-in-liver-transplantation-when-using-octogenarian-donors-a-retrospective-cohort-study
#2
Davide Ghinolfi, Giovanni Tincani, Erion Rreka, Niccolo' Roffi, Laura Coletti, Emanuele Balzano, Gabriele Catalano, Sonia Meli, Paola Carrai, Stefania Petruccelli, Gianni Biancofiore, Franco Filipponi, Paolo De Simone
Several risk factors for ischemic-type biliary lesions (ITBL) after liver transplantation (LT) have been identified, but the role of portal vein perfusion at graft procurement is still unclear. This was a prospective study on double aortic and portal perfusion (DP) of liver grafts stratified by donor's decade (<60yo;60-69yo;70-79yo and≥80yo) versus similar historical cohorts of primary, adult grafts procured with single aortic perfusion (SP) only. The primary study aim was to assess the role of DP on the incidence of ITBL...
September 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30179275/a-method-to-reduce-variability-in-scoring-anti-body-mediated-rejection-in-renal-allografts-implications-for-clinical-trials
#3
Byron Smith, Lynn D Cornell, Maxwell Smith, Cherise Cortese, Xochiquetzal Geiger, Mariam P Alexander, Margaret Ryan, Walter Park, Martha Catalina Morales Alvarez, Carrie Schinstock, Walter Kremers, Mark Stegall
Poor reproducibility in scoring antibody mediated rejection (ABMR) using the Banff criteria might limit the use of histology in clinical trials. We evaluated the reproducibility of Banff scoring of 67 biopsies by 6 renal pathologists at 3 institutions. Agreement by any two pathologists was poor: 44.8%-65.7% for glomerulitis, 44.8%-67.2% for peritubular capillaritis, and 53.7%-80.6% for chronic glomerulopathy (cg). All pathologists agreed on cg0 (n=20) and cg3 (n= 9) cases, however, many disagreed on scores of cg1 or cg2...
September 4, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30176087/the-impact-of-time-varying-clinical-surrogates-on-disparities-in-african-american-kidney-transplant-recipients-a-retrospective-longitudinal-cohort-study
#4
David J Taber, Zemin Su, James N Fleming, Nicole A Pilch, Thomas Morinelli, Patrick Mauldin, Derek Dubay
An improved understanding of the impact of clinical surrogates on disparities in African-American (AA) kidney transplantation (KTX) is needed. We conducted a 10-year retrospective longitudinal cohort study of electronically abstracted clinical data assessing the impact of surrogates on disparities in KTX. Clinical surrogates were assessed by post-transplant year (1, 2, 3 or 4) and defined as acute rejection (Banff≥1A), mean SBP >140 mmHg, tacrolimus variability (CV) >40%, mean glucose >160 mg/dL and mean hemoglobin <10 gm/dL...
September 3, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30152892/do-you-really-know-what-you-get-the-benefits-and-doubts-of-domino-liver-transplantation
#5
Wolf Bechstein, Andreas Schnitzbauer
Liver transplantation (LT) has perhaps been the first long-term clinically successful gene-therapy to provide patients with an in-born error of metabolism a near normal life. Some of these metabolic defects with an indication for liver transplantation are associated with an otherwise structurally and functionally complete normal liver. With these scenarios the concept of domino liver transplantation has been established. The liver of the recipient with a liver based metabolic disease can be "recycled" and transplanted into another recipient instead of being sent off to pathology...
August 28, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30152891/downstaging-prior-to-liver-transplantation-for-hepatocellular-carcinoma-advisable-but-at-the-price-of-an-increased-risk-of-cancer-recurrence-a-retrospective-study
#6
Christian Toso, Glenda Meeberg, Axel Andres, Carolina Shore, Colleen Saunders, David L Bigam, Andrew Mark James Shapiro, Philippe Compagnon, Thierry Berney, Pietro Majno, Norman Kneteman
The use of downstaging prior to liver transplantation for hepatocellular carcinoma (HCC) still needs refinement. This study included patients with HCC listed for transplantation according to the Total Tumour Volume (TTV) ≤115 cm3 and alpha fetoprotein (AFP) ≤400 ng/ml criteria, with and without previous downstaging. Overall, 455 patients were listed, and 286 transplanted. Post-transplant follow-up was 38.5 ± 1.7 months. Patients downstaged to TTV115/AFP400 (n = 29) demonstrated similar disease-free survivals (DFS, 74% vs...
August 28, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30152890/interaction-between-socioeconomic-deprivation-and-likelihood-of-pre-emptive-transplantation-influence-of-competing-risks-and-referral-characteristics
#7
Keith A Gillis, Jennifer S Lees, Maximilian R Ralston, Julie A Glen, Karen S Stevenson, Siobhan K McManus, Colin C Geddes, Marc Clancy, Jamie P Traynor, Patrick B Mark
BACKGROUND: Socioeconomic deprivation (SED) influences likelihood of pre-emptive kidney transplantation (PET), but the mechanisms behind this are unclear. We explored the relationships between SED and patient characteristics at referral, which might explain this discrepancy. METHODS: A retrospective cohort study was performed. SED was measured by Scottish Index of Multiple Deprivation (SIMD). Logistic regression evaluated predictors of PET. A competing risks survival analysis evaluated the interaction between SED and progression to end stage kidney disease (ESKD) and death...
August 28, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30144365/assessment-of-donor-satisfaction-as-an-essential-part-of-living-donor-kidney-transplantation-an-eleven-year-retrospective-study
#8
Ana Menjivar, Xavier Torres, David Paredes, Nuria Avinyo, Josep Maria Peri, Erika De Sousa-Amorim, Federico Oppenheimer, Marti Manyalich, Fritz Diekmann, Ignacio Revuelta
Living kidney donors seem highly satisfied with donation. However, previous studies measure satisfaction by a single-item or by simply questioning donors' willingness to donate again or to recommend living donation. With the aim of analyzing whether satisfaction with donation is a multidimensional construct, thus allowing a more specific characterization of dissatisfied donors, 332 living kidney donors (2005-2015) answered a renewed version of the European Living Donation and Public Health Project satisfaction survey...
August 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30144356/a-retrospective-analysis-of-re-exploration-after-living-donor-right-lobe-liver-transplantation-incidence-causes-outcomes-and-risk-factors
#9
Jungchan Park, Gyu-Seong Choi, Mi Sook Gwak, Sangwook Justin Ko, Bobae Han, Sangbin Han, Jae Won Joh, Suk-Koo Lee, Jongman Kim, Gaab Soo Kim
Despite technical difficulties, right lobe liver grafting is preferred in living donor liver transplantation because of the graft size. Re-exploration after living donor right lobe liver transplantation (LRLT) has never been separately analyzed. We aimed to analyze the incidence, causes, outcomes, and risk factors of re-exploration after LRLT. We reviewed medical records of 1016 LRLT recipients from October 2003 to July 2017 and identified recipients who underwent re-exploration within hospital stay. Separate analyses were also performed according to cause of re-exploration...
August 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30118554/reply-to-ex-situ-normothermic-machine-perfusion-of-donor-livers-using-a-hemoglobin-based-oxygen-carrier-a-viable-alternative-to-red-blood-cells
#10
LETTER
Dilmurodjon Eshmuminov, Filippo Leoni, Marcel André Schneider, Dustin Becker, Xavier Muller, Max Hefti, Martin Schuler, Christopher Onder, Philipp Dutkowski, Rolf Graf, Philipp Rudolf von Rohr, Pierre-Alain Clavien, Lucia Bautista Borrego
We highly appreciate the interest expressed in the letter by de Vries et all concerning our recent systematic review (1, 2), and congratulate for the successful transplantation using HBOC during normothermic perfusion. We agree, that ex situ normothermic and also subnormothermic liver perfusion using HBOC is per se an interesting option to spare red blood cells as oxygen carrier. This article is protected by copyright. All rights reserved.
August 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30118552/performances-of-creatinine-based-gfr-estimating-equations-in-simultaneous-pancreas-kidney-transplant-recipients-a-single-center-cohort-study
#11
Allyriane Dantec, Luciano Selistre, Sandrine Lemoine, Fanny Buron, Vandréa Carla de Souza, Thomas Rimmelé, Olivier Thaunat, Lionel Badet, Emmanuel Morelon, Laurence Dubourg, Antoine Sicard
BACKGROUND: Estimating glomerular filtration rate (GFR) is important for clinical management and research studies in simultaneous pancreas-kidney transplantation (SPK) recipients. No study has specifically investigated the reliability of recent creatinine-based GFR estimating equations in this singular population. We assessed the performances of CKD-EPI, MDRD, Schwartz-2009, Schwartz-Lyon, Lund-Malmo and Full Age Spectrum equations for estimating GFR after SPK. METHODS: 126 patients were included...
August 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30118162/need-for-caudate-duct-classification-god-is-in-the-detail-and-so-is-the-devil
#12
LETTER
Kausar Makki, Vishal Chorasiya, Ashish Singhal, Ajitabh Srivastava, Arif Ali Khan, Vivek Vij
Caudate duct classification is important not only in understanding the complex hilar anatomy intraoperatively but also in post-operative decision making in management of biliary complications. This article is protected by copyright. All rights reserved.
August 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30106185/long-term-cardiovascular-outcome-of-renal-transplant-recipients-after-early-conversion-to-everolimus-compared-to-calcineurin-inhibition-results-from-the-randomized-controlled-mecano-trial
#13
Marja van Dijk, Arie M van Roon, M Yusof Said, Frederike J Bemelman, Jaap J Homan van der Heide, Hans W de Fijter, Aiko P J de Vries, Stephan J L Bakker, Jan Stephan F Sanders
Long-term data on cardiovascular (CV) outcome of renal transplant recipients (RTR) on mTOR-i (mammalian Target Of Rapamycin-inhibitors) are scarce. In a sub-study of the MECANO trial we investigated changes in intima media thickness (IMT), CV risk profile, Major Adverse CV Events (MACE) and survival in RTR on a mTORi versus CNI based regimen. Patients (enrolled 361) were treated with (basiliximab) and triple IS (CsA-Cyclosporine A-(C), MPS (M), prednisolone (P)). At M6 patients were randomized (n = 224) to the CsA group (C, P, N = 89), MPS group (M, P, N = 39) EVL group (Everolimus, P, N = 96)...
August 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30099788/vitamin-d-status-and-risk-of-infections-after-liver-transplantation-in-the-swiss-transplant-cohort-study
#14
Peter W Schreiber, Heike A Bischoff-Ferrari, Katia Boggian, Christian van Delden, Natalia Enriquez, Thomas Fehr, Christian Garzoni, Hans H Hirsch, Cédric Hirzel, Oriol Manuel, Pascal Meylan, Lanja Saleh, Maja Weisser, Nicolas J Mueller
Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency [25-OH vitamin D (25-OHD) <50 nmol/l] and no deficiency (25-OHD ≥50 nmol/l) in incident infections after liver transplantation. In 135 liver transplant recipients, blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the Swiss Transplant Cohort Study database...
August 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30099780/frailty-has-a-significant-influence-on-postoperative-complications-after-kidney-transplantation-a-prospective-study-on-short-term-outcomes
#15
Lasse Schopmeyer, Mostafa El Moumni, Gertrude J Nieuwenhuijs-Moeke, Stefan P Berger, Stephan J L Bakker, Robert A Pol
Currently, there are no tools to predict postsurgery outcome after kidney transplantation. This study assesses whether frailty influence 30-day postoperative complications after kidney transplantation. One-hundred and fifty kidney transplantations were prospectively included. Frailty was assessed using a frailty indicator, consisting of 15 questions, covering most domains of functioning. Postoperative complications were measured by the Comprehensive Complication Index (CCI). Using a linear regression model, 30-day postoperative complications and frailty correlation were adjusted for confounders, including sex, age, ASA Score, Charlson Comorbidity Index, hypertension, BMI, smoking, dialysis, duration of dialysis, type of transplantation, and retransplantation...
August 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30099769/standardized-intraoperative-application-of-an-absorbable-polysaccharide-hemostatic-powder-to-reduce-the-incidence-of-lymphocele-after-kidney-transplantation-a-prospective-trial
#16
Christopher K Burghuber, Daniela Kandioler, Stephanie Strobl, Martina Mittlböck, Georg A Böhmig, Thomas Soliman, Gabriela A Berlakovich
We assessed whether standardized application of an absorbable polysaccharide hemostatic powder (HaemoCer™) has an effect on lymphocele rate after kidney transplantation. For this nonrandomized prospective trial, we first aimed to know our center-specific lymphocele rate diagnosed by ultrasound imaging. We retrospectively assessed all patient records of the elapsed year resulting in a center-specific rate of 20%, this was consistent with literature. The power analysis showed that 108 patients were required to detect a 50% reduction in lymphocele rate...
August 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30091231/technical-challenges-and-clinical-relevance-of-single-antigen-bead-c1q-c3d-testing-and-igg-subclass-analysis-of-human-leukocyte-antigen-antibodies
#17
REVIEW
Gonca E Karahan, Frans H J Claas, Sebastiaan Heidt
Luminex single antigen bead assays revolutionized human leukocyte antigen (HLA) antibody detection owing to their superior sensitivity compared to conventional methods. Nevertheless, the advent of higher sensitivity came at the expense of difficulty in clinical decision-making, since not all luminex detectable antibodies are clinically relevant. Therefore, new tools such as C1q/C3d assays and IgG subclass analysis emerged with the aim to discriminate the inert antibodies from the deleterious ones. Here, we provide an overview on the technical challenges related to these different HLA antibody detection systems and briefly refer to the recent literature regarding the clinical relevance of these assays, mainly in the field of kidney transplantation...
August 9, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30091268/progression-of-transthyretin-ttr-amyloidosis-in-donors-and-recipients-after-domino-liver-transplantation-a-prospective-single-center-cohort-study
#18
Johanna Vollmar, Julia C Schmid, Maria Hoppe-Lotichius, Ana P Barreiros, Mimoun Azizi, Tilman Emrich, Christian Geber, Arno Schad, Veronica Weyer, Gerd Otto, Michael Heise, Jens Mittler, Frank Birklein, Hauke Lang, Peter R Galle, Tim Zimmermann
Liver transplantation (LT) is the first-line therapy in patients with transthyretin (TTR) amyloidosis and progressive familial amyloid polyneuropathy (FAP). Explanted organs from these patients can be used for domino liver transplantation (DLT). After DLT, de novo amyloidosis may develop in domino recipients (DR). Data were collected prospectively in a transplant database. Electroneurography by nerve conduction velocity (NCV), quantitative sensory testing, heart rate variability (HRV), sympathetic skin response, orthostatic reaction (tilt table test), transthoracic echocardiography, cardiac MRI and organ biopsy results were evaluated...
August 8, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30076765/failure-to-remove-de-novo-donor-specific-hla-antibodies-is-influenced-by-antibody-properties-and-identifies-kidney-recipients-with-late-antibody-mediated-rejection-destined-to-graft-loss-a-retrospective-study
#19
Michela Cioni, Arcangelo Nocera, Augusto Tagliamacco, Sabrina Basso, Annalisa Innocente, Iris Fontana, Alberto Magnasco, Antonella Trivelli, Catherine Klersy, Antonella Gurrado, Miriam Ramondetta, Stella Boghen, Laura Catenacci, Enrico Verrina, Giacomo Garibotto, Gian Marco Ghiggeri, Massimo Cardillo, Fabrizio Ginevri, Patrizia Comoli
Current research is focusing on identifying bioclinical parameters for risk stratification of renal allograft loss, largely due to antibody-mediated rejection (AMR). We retrospectively investigated graft outcome predictors in 24 unsensitized pediatric kidney recipients developing HLA de novo donor-specific antibodies (dnDSAs), and treated for late AMR with plasmapheresis + low-dose IVIG + Rituximab or high-dose IVIG + Rituximab. Renal function and DSA properties were assessed before and longitudinally post treatment...
August 4, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30062716/paricalcitol-versus-placebo-for-reduction-of-proteinuria-in-kidney-transplant-recipients-a-double-blind-randomized-controlled-trial
#20
Manca Oblak, Gregor Mlinšek, Aljoša Kandus, Jadranka Buturović-Ponikvar, Miha Arnol
Proteinuria after kidney transplantation is accompanied by an increased risk of graft failure. In this single-center, placebo-controlled, double-blind trial we studied whether vitamin D receptor activator paricalcitol might reduce proteinuria. Patients with urinary protein-to-creatinine ratio (UPCR) ≥20 mg/mmol despite optimization of the renin angiotensin aldosterone system (RAAS) blockade were randomly assigned to receive 24 weeks' treatment with 2 μg/day paricalcitol or placebo. Primary endpoint was change in UPCR, and main secondary endpoints were change in urinary albumin-to-creatinine ratio (UACR) and 24-h proteinuria...
July 31, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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