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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/28326627/obituary-thomas-earl-starzl-the-father-of-transplantation-march-11-1926-march-4-2017-to-be-published-in-esot-newsletter-transplant-international
#1
Jan P Lerut
March 2016…the transplant community celebrated with pomp the 90(th) birthday of transplantation pioneer, Th. E. Starzl. More than 400 surgeons and scientists originating from all over the United States and from all five continents met in Pittsburgh to pay tribute to their mentor, teacher and friend. The 'Starzl family at large' experienced a once in a lifetime event ending with a thoughtful, but typical (Fig. 1) 'Starzl speech' about past and future, including a humoristic but realistic view on life and ageing...
March 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28319322/an-analysis-of-the-survival-outcomes-of-simultaneous-pancreas-and-kidney-transplantation-compared-to-live-donor-kidney-transplantation-in-patients-with-type-1-diabetes-a-uk-transplant-registry-study
#2
Adam D Barlow, Kourosh Saeb-Parsy, Christopher J E Watson
BACKGROUND: Transplant options for patients with type 1 diabetes and end-stage renal disease (ESRD) include deceased donor kidney, live donor kidney (LDK) and simultaneous pancreas-kidney (SPK) transplantation. The aim of this study was to compare outcomes between LDK and SPK for patients with type 1 diabetes and ESRD in the UK. METHODS: Data on all SPK (n=1739) and LDK (n=385) transplants performed between January 2001 and December 2014 were obtained from the UK Transplant Registry...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28319288/impact-of-single-centre-kidney-paired-donation-transplantation-to-increase-the-donor-pool-in-india
#3
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priyadarshini S Shah, Manisha P Modi, Beena P Butala, Pavan S Wakhare, Umesh T Varyani, Saiprasad G Shinde, Vijay A Ghodela, Govind S Kasat, Mayur V Patil, Jaideep C Patel, Deepk P Kumar, Varsha B Trivedi, Minaxi H Patel, Hargovind L Trivedi
In a living donor kidney transplantation (LDKT) dominated transplant programme, kidney paired donation (KPD) may be a cost-effective and valid alternative strategy to increase LDKT in countries with limited resources where deceased donation kidney transplantation (DDKT) is in the initial stages. Here, we report our experience of 300 single-centre KPD transplantations to increase LDKT in India. Between January 2000 and July 2016, 3616 LDKT and 561 DDKT were performed at our transplantation centre, 300 (8.3%) using KPD...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28295760/variability-in-assessing-for-bk-viremia-whole-blood-is-not-reliable-and-plasma-is-not-above-reproach-a-retrospective-analysis
#4
Neerja Agrawal, Ignacio A Echenique, Shane M Meehan, Ajit P Limaye, Linda Cook, Anthony Chang, Robert C Harland, Basit Javaid, Pradeep V Kadambi, Scott Matushek, James Williams, Michelle A Josephson
Polyomavirus nephropathy (PVN) is a major complication of kidney transplantation. Most reports describe polyomavirus viremia either precedes or is detectable at the time of diagnosis of PVN. This association is the basis of current screening recommendations. We retrospectively reviewed the PCR results of blood and urine samples from 29 kidney transplant recipients with biopsy proven PVN. Biopsies were performed for a rise in serum creatinine or persistent high-level BK viruria. All biopsies had polyoma virus large T-antigen expression in tubular epithelium by immunohistochemistry...
March 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28295643/prophylaxis-of-lymphocele-formation-after-kidney-transplantation-via-peritoneal-fenestration-a-systematic-review
#5
André Leopold Mihaljevic, Patrick Heger, Sepehr Abbasi Dezfouli, Mohammad Golriz, Arianeb Mehrabi
BACKGROUND: Lymphocele formation after kidney transplantation is a frequent complication which causes pain, secondary graft loss, rehospitalisations and reoperations. Therefore prophylaxis of lymphocele formation is of utmost importance. OBJECTIVE: To assess the effectiveness of peritoneal fenestration in renal transplantation to prevent lymphocele development METHODS: A systematic literature search was conducted combined with hand-searches on lymphocele prevention following renal transplantation using peritoneal fenestration...
March 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28295620/kidney-dysfunction-after-cardiac-transplantation-does-early-acute-kidney-injury-translate-into-inferior-long-term-patient-and-renal-outcomes
#6
Miha Arnol, Ivan Kneževič
Both cardiac and kidney diseases are extremely common in the population and are intimately interconnected. First, both conditions share several etiological factors (e.g., hypertension, diabetes mellitus). Second, a steady stream of studies has highlighted the negative heart-kidney interaction in such a way that any acute or chronic dysfunction of the former may affect the latter, and reciprocally, as part of the cardiorenal syndromes [1]. This article is protected by copyright. All rights reserved.
March 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28295675/improved-detection-of-alcohol-consumption-using-the-novel-marker-phosphatidylethanol-in-the-transplant-setting-results-of-a-prospective-study
#7
Hilke Andresen-Streichert, Yannick Beres, Wolfgang Weinmann, Alexandra Schröck, Alexander Müller, Gisela Skopp, Sven Pischke, Eik Vettorazzi, Ansgar Lohse, Björn Nashan, Martina Sterneck
MAIN PROBLEM: Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. METHODS: In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate deficient transferrin (CDT), ethylglucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. RESULTS: 28 (25%) patients tested positive for at least one alcohol marker...
March 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28295670/high-resource-utilization-in-liver-transplantation-how-strongly-differ-costs-between-the-care-sectors-and-what-are-the-main-cost-drivers
#8
Lena Harries, Harald Schrem, Jona T Stahmeyer, Christian Krauth, Volker Eric Amelung
To control treatment pathways of transplant patients across health care sectors a profound knowledge of the underlying cost structure is necessary. The aim of this study was to analyze the resource utilization of patients undergoing liver transplantation. Data on resource utilization for 182 liver transplanted patients was investigated retrospectively. The observational period started with the entry on the waiting list and ended up to 3 years after transplantation. Median treatment cost was 144,424€. During waiting time median costs amounted to 9,466€; 72% of costs were attributed to inpatient care, 3% to outpatient care and 26% to pharmaceuticals...
March 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28267237/transplantation-of-adult-living-donor-kidneys-in-small-children-a-single-center-initial-experience
#9
LETTER
Josianne Chbm Luijten, Marieke Voet, Robert Pe de Gier, Anneliese Nusmeier, Horst Scharbatke, J Adam van der Vliet, Elisabeth Am Cornelissen
Kidney transplantation (KTx) is the best treatment for children with ESRD (1). Pre-emptive KTx results in better survival and graft function when compared to KTx after initiation of dialysis (2, 3). To prevent impaired neurologic development KTx should not be delayed (4). Early transplantation however, is hampered due to shortness in paediatric donor kidneys. Fortunately parents are often willing to donate, but the transplantation of an adult-sized kidney (ASK) in a small recipient is associated with some challenges...
March 7, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28267230/keep-the-pressure-correlation-of-hemodynamic-instability-after-reperfusion-and-severity-of-acute-kidney-injury-following-liver-transplantation
#10
Jonas Roller, Matthias Glanemann
Acute renal dysfunction and kidney failure represent frequent complications in patients after liver transplantation. Indeed, postoperative acute kidney injury (AKI) may occur in up to 60% and is associated with significantly increased postoperative mortality [1], however, the pathogenesis of AKI is yet not fully understood. To date it is not possible to identify patients with an increased risk for AKI prior to transplantation, thus, the treatment remains clinically challenging. This article is protected by copyright...
March 7, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28252226/death-of-recipients-after-kidney-living-donation-triples-donors-risk-of-dropping-out-from-follow-up
#11
Xavier Torres, Jordi Comas, Emma Arcos, Jaume Tort, Fritz Diekmann
Although kidney transplantation from the donation of a living donor is a safe treatment for end-stage renal disease, inferences about safety of living kidney donors might be biased by an informative censoring caused by the non-inclusion of a substantial percentage of donors lost-to-follow-up. With the aim of assessing the presence of a potential informative censoring in living kidney donation outcomes of Catalan donors for a period of 12 years, 573 donors followed and lost-to-follow-up were compared. Losses of follow-up over time were also assessed by univariate and multivariate survival analysis, along with Cox regression...
March 2, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28236641/czech-austrian-kidney-paired-donation-first-european-cross-border-living-donor-kidney-exchange
#12
LETTER
Georg A Böhmig, Jiří Fronek, Antonij Slavcev, Gottfried F Fischer, Gabriela Berlakovich, Ondrej Viklicky
Kidney paired donation (KPD) is an efficient strategy to circumvent major immunological barriers in patients who have a willing and medically able, but incompatible living donor. In recent years, several countries have developed successful KPD programs, including highly active multicenter alliances in the United States, and even international cross-border kidney shipment has been documented (1-3). In Europe, several countries are running independent KPD programs, with the Dutch program being the most prominent (4)...
February 25, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28236638/patients-preferences-in-transplantation-from-marginal-donors-results-of-a-discrete-choice-experiment
#13
Sara Kamran, Filomena Conti, Marie-Pascale Pomey, Gabriel Baron, Yvon Calmus, Gwenaëlle Vidal-Trecan
MAIN PROBLEM: To increase the donor pool, the strategy of transplantation from "marginal" donors was developed though patients' preferences about these donors were insufficiently known. METHODS: The preferences of patients registered on the waiting list or already transplanted in eight transplant teams covering four main organs (i.e, kidney, liver, heart and lung) were evaluated using the discrete choice experiment method. In each center during two days, patients were interviewed on four scenarios...
February 25, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28236636/re-evaluation-of-glomerulitis-using-occlusion-criteria-based-on-the-banff-2013-revision
#14
Yasemin Ozluk, Yasar Caliskan, Mustafa Sevinc, Aysel Bayram, Evsen Apaydin Arikan, Aydin Turkmen, Sebahat Akgul, Fatma Oguz Savran, Mehmet Sukru Sever, Isin Kilicaslan
The presence of occlusion/near-occlusion of glomerular capillaries was recently added to the existing definition of glomerulitis (g). We retrospectively re-evaluated 135 renal allograft biopsies regarding g to ensure no antibody-damaged grafts were missed. Previous and revised g scores (pg and rg, respectively) were compared for clinicopathologic correlations. The g score did not change in 100 (74.1%) biopsies. Thirty-five (25.9%) biopsies were changed to a lower score. Sensitivity and specificity of pg and rg for the presence of donor specific antibodies (DSA) were 76% vs...
February 25, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28226189/equitable-distribution-in-rare-indications-for-liver-transplantation-the-dilemma-of-the-too-small-tablecloth-continues
#15
Andreas A Schnitzbauer, Wolf O Bechstein
Primary biliary cholangitis (formerly known as primary biliary cirrhosis) has been a classic indication for liver transplantation for more than thirty years (1). Due to the changing epidemiology of liver diseases combined with the universal lack of post-mortal grafts, the question of prioritizing allocation amongst sick patients competing for these rare grafts on the waiting list remains an unresolved challenge. In their UNOS database analysis Ashwani Singal and coworkers focus on wait-list mortality for a nowadays rare indication for liver transplantation: primary biliary cholangitis (PBC) (2)...
February 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28218993/reply-to-an-evolving-understanding-of-modifiable-risk-factors-for-post-transplant-mortality
#16
LETTER
Sikarin Upala, Anawin Sanguankeo, Theppharit Panichsillapakit, Karn Wijarnpreecha, Veeravich Jaruvongvanich
We thanked Rinaldi et al. who interested in our study entitled "Underweight and obesity increase the risk of mortality after lung transplantation: a systematic review and meta-analysis" (1) and gave an interesting thought and suggestion. Rinaldi et al. questioned why earlier studies from the same databases such as the work by Lederer et al. (2) and Allen et al. (3), which used the United Network for Organ Sharing database, were excluded from meta-analysis. This article is protected by copyright. All rights reserved...
February 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28218990/renal-function-at-one-year-after-cardiac-transplantion-rather-than-acute-kidney-injury-is-highly-associated-with-long-term-patient-survival-and-loss-of-renal-function
#17
Gijs Fortrie, Olivier C Manintveld, Alina A Constantinescu, Pieter C van de Woestijne, Michiel G H Betjes
BACKGROUND: The current study aims to assess the association between acute kidney injury (AKI), renal function one year after transplantation and long-term adverse outcomes after cardiac transplantation. METHODS: A retrospective cohort study was performed including 471 adult cardiac transplantation recipients that survived the first postoperative year between 1984 and 2012. Primary outcome variables were long-term overall and renal survival. RESULTS: During the first postoperative week 40% (n=288) of the recipients developed AKI stage I, 22% (n=104) stage II, 13% (n=63) stage III and 4% (n=17) required temporary RRT...
February 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28218989/liver-transplantation-from-donors-with-positive-blood-cultures-increased-risk-of-graft-failure-or-opportunity-to-expand-the-donor-pool
#18
Paolo Antonio Grossi
Organ transplantation is considered the therapy of choice for end-stage organ failure. However, the growing gap between the number of patients waiting for transplantation and available organs continue to be the number one issue facing the transplant community. As a consequence the major focus in liver transplantation has been developing strategies to increase available donors, including the use of live donor liver segments, splitting deceased donor grafts for two patients and the use of organs procured from donors after circulatory death (DCD)...
February 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28218437/an-evolving-understanding-of-modifiable-risk-factors-for-post-transplant-mortality
#19
LETTER
S Rinaldi, J Horne, J Madill
With great interest, we read the recently published article in Transplant International by Upala et al. entitled Underweight and obesity increase the risk of mortality after lung transplantation: a systematic review and meta-analysis [1]. To-date, lung transplant clinical practice guidelines have been based on expert opinions or site-specific experiences. The authors should be commended for recognizing the need to assess articles with rigorous study designs in order to guide evidence-based practice. In their recent work, Upala et al...
February 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28211192/racial-differences-in-incident-de-novo-donor-specific-anti-hla-antibody-among-primary-renal-allograft-recipients
#20
Matthew J Everly, Kimberly P Briley, Carl E Haisch, Georg Dieplinger, Paul Bolin, Scott A Kendrick, Claire Morgan, Angela Q Maldonado, Lorita M Rebellato
Controversy exists as to whether African American (AA) transplant recipients are at risk for developing de novo donor-specific anti-human leukocyte antigen (HLA) antibody (dnDSA). We studied 341 HLA-mismatched, primary renal allograft recipients who were consecutively transplanted between 3/1999 and 12/2010. Sera were collected sequentially pre- and post-transplant and tested for anti-HLA immunoglobulin G (IgG) via single antigen bead assay. Of the 341 transplant patients (225 AA and 116 non-AA), 107 developed dnDSA at a median of 9...
February 17, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
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