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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/30016550/survival-following-right-lobe-split-graft-living-and-deceased-donor-liver-transplantation-in-adult-patients-a-systematic-review-and-network-meta-analysis
#1
REVIEW
Paschalis Gavriilidis, Aurelio Tobias, Robert P Sutcliffe, Keith J Roberts
BACKGROUND: Graft and patient survival outcomes following split liver transplantation (SLT), living-donor liver transplantation (LDLT), and deceased-donor liver transplantation (DDLT) were estimated using Bayesian network meta-analysis. METHODS: Databases were searched for relevant articles over the previous 20 years (MEDLINE, Embase, Cochrane Library, and Google Scholar). Systematic review, pair-wise meta-analysis, and Bayesian network meta-analysis were performed...
July 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30007072/early-allograft-inflammation-and-scarring-associate-with-graft-dysfunction-and-poor-outcomes-in-renal-transplant-recipients-with-delayed-graft-function
#2
Aravind Cherukuri, Rajil Mehta, Puneet Sood, Sundaram Hariharan
Early histological progression that associates with Delayed Graft Function (DGF) and its relationship to graft outcomes is less well understood. We systematically evaluated early acute and chronic histological changes associated with DGF through serial biopsies (protocol: 3 and 12mos; for-cause) and related them to graft outcomes. 56/294 (19.04%) of our patients had DGF. DGF was associated with a progressive increase in both Banff 't' and 'i' scores from 2 weeks to 3 and 12 months with a resultant increase in T cell mediated Rejection (TCMR) that was significantly greater than those with primary graft function (PGF)...
July 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29981189/first-report-of-a-living-liver-graft-in-combined-lung-and-liver-transplantation
#3
LETTER
Dong Jin Joo, Seung Hwan Song, Dai Hoon Han, Moo Suk Park, Anes Kim, Kyoung Ok Jeon, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Hyo Chae Paik
There is no organ allocation priority for combined organ transplantation in Korea. It is therefore difficult for patients who have both lung and liver failure to be matched to both organs simultaneously, particularly in patients for whom only a single organ is acutely driving the need for transplant while the failure of the other is not as severe. Combined lung and living donor liver transplantation (CLLDLT) is an alternative option for such patients. This article is protected by copyright. All rights reserved...
July 6, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29981183/lung-transplant-after-prolonged-ex-vivo-lung-perfusion-predictors-of-allograft-function-in-swine
#4
John R Spratt, Lars M Mattison, Paul A Iaizzo, Carolyn Meyer, Roland Z Brown, Tinen Iles, Angela Panoskaltsis-Mortari, Gabriel Loor
Portable normothermic EVLP has been evaluated in clinical trials using standard and extended-criteria donor lungs. We describe a swine model of lung transplant following donation after circulatory death using prolonged normothermic EVLP to assess the relationship between EVLP data and acute lung allograft function. Adult swine were anesthetized and heparinized. In the control group (n=4), lungs were procured, flushed, and transplanted. Treatment swine underwent either standard procurement (n=3) or agonal hypoxia followed by 1 (n=4) or 2 hours (H) (n=4) of ventilated warm ischemia...
July 6, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29974521/%C3%AE-lipoic-acid-reduces-post-reperfusion-syndrome-in-human-liver-transplantation-a-pilot-study
#5
Paola Casciato, Nella Ambrosi, Fiorella Caro, Mónica Vazquez, Eduardo Müllen, Adrian Gadano, Eduardo de Santibañes, Martín de Santibañes, Marcos Zandomeni, Magali Chahdi, Julio C Lazarte, David A Biagiola, Juan Cruz Iaquinandi, Patricia Santofimia-Castaño, Juan Iovanna, Claudio Incardona, Eduardo Chuluyan
A double-blind randomized controlled trial was performed to compare the safety and efficacy of α-lipoic acid(ALA) in liver transplantation. The grafts were randomized to receive ALA or placebo before the cold ischemia time. Furthermore, patients transplanted with the ALA-perfused graft received 600mg of intravenous ALA, while patients with the non-perfused graft received the placebo just before graft reperfusion. Hepatic biopsy was performed 2 hours post-reperfusion. Blood samples were collected before, during and 1 and 2 days after reperfusion...
July 5, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29969826/the-impact-of-everolimus-in-reducing-cytomegalovirus-events-in-kidney-transplant-recipients-on-steroid-avoidance-strategy-3-year-follow-up-of-a-randomized-clinical-trial
#6
Tainá Veras de Sandes-Freitas, Petrucia Maria Antero Pinheiro, Maria Luíza de Mattos Brito Oliveira Sales, Celi Melo Girão, Érika Fernandes Campos, Ronaldo de Matos Esmeraldo
There is no evidence of whether everolimus(EVR) reduces cytomegalovirus(CMV) events in patients receiving steroid-free regimens.Besides, studies evaluating a tacrolimus(TAC) and EVR regimen are limited to 1-year follow-up. In this single-center prospective randomized trial, the incidence of CMV and 3-year efficacy and safety outcomes of EVR were compared to those of mycophenolate sodium(MPS) in a steroid-free regimen based on low-exposure TAC.Both groups received rabbit anti-thymocyte globulin(r-ATG) induction(6mg/kg) and the steroids were withdrawn at day 7...
July 3, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29957882/transplantation-within-the-era-of-anti-il-1-therapy-case-series-of-5-patients-with-familial-mediterranean-fever-related-amyloidosis
#7
LETTER
Z Birsin Özçakar, Kenan Keven, Nilgün Çakar, Fatoş Yalçınkaya
Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory disease [1]. Amyloidosis still continues to occur during the colchicine era, with a rate of 11.4%, in untreated and noncompliant FMF patients [2]. Longterm outcomes of patients with FMF related amyloidosis who had received kidney transplantation were controversial [3-6]. This article is protected by copyright. All rights reserved.
June 29, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29957863/preliminary-experience-of-sequential-use-of-normothermic-and-hypothermic-oxygenated-perfusion-for-dcd-kidney-with-warm-ischemia-time-over-the-conventional-criteria
#8
Matteo Ravaioli, Vanessa De Pace, Giorgia Comai, Irene Capelli, Olga Baraldi, Antonietta D'Errico, Valentina Rosa Bertuzzo, Massimo Del Gaudio, Chiara Zanfi, Giovanni Liviano D'Arcangelo, Vania Cuna, Antonio Siniscalchi, Gabriela Sangiorgi, Gaetano La Manna
BACKGROUND: Donation after circulatory death (DCD) is a potential source of reducing organ demand. In Italy, DCD requires a 20 minutes no-touch period, that prolongs warm ischemia and increases delayed graft function (DGF) risk and graft loss. We report here our preliminary experience of sequential use of normothermic regional perfusion (NRP), as standard procedure, and hypothermic oxygenated perfusion (HOPE), as an experimental technique of organ preservation, in 10 kidney transplants (KT) from 5 DCD-Maastricht III with extensive functional warm ischemia time (fWIT) up to 325 minutes...
June 29, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29953680/hypoxia-inducible-factor-controls-immunoregulatory-properties-of-myeloid-cells-in-mouse-cardiac-allografts
#9
Mikko A I Keränen, Alireza Raissadati, Antti I Nykänen, Alexey Dashkevich, Raimo Tuuminen, Rainer Krebs, Randall S Johnson, Simo O Syrjälä, Karl B Lemström
Hypoxia-inducible factors (HIF) play a critical role in inflammatory properties of myeloid-derived cells. The effect of HIFs on myeloid-derived cell functions in organ transplantation remains unknown, however. We transplanted hearts into transgenic mice with myeloid cell-targeted deletions of HIF-1α or its negative regulator von Hippel-Lindau (VHL) to investigate the effects of HIF-1α inactivation or HIF-pathway activation, respectively, on ischemia-reperfusion injury (IRI) and acute rejection. Deletion of VHL in myeloid cells enhanced mRNA expression of anti-inflammatory genes IDO, Arg-1, and HO-1 in vitro...
June 28, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29984844/new-onset-obesity-after-liver-transplantation-outcomes-and-risk-factors-the-swiss-transplant-cohort-study
#10
Sonja Beckmann, Kris Denhaerynck, Susanne Stampf, Nuria Saigi-Morgui, Isabelle Binet, Michael Koller, Elsa Boely, Sabina De Geest
Weight gain after liver transplantation (LTx) facilitates development of new-onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new-onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new-onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new-onset obesity in 253 adults (mean age 52.2 ± 11.6 years, male gender 63.6%, mean follow up 5.7 ± 2.1 years). Cumulative incidence of post-LTx CVE was 28...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29931694/controlled-donation-after-circulatory-death-in-france-first-results-of-a-non-university-pilot-centre
#11
LETTER
Samuel Gay, Albrice Levrat, Didier Dorez
France started is national controlled donation after circulatory death (cDCD) programme in December 2014. We present the first 2 year results of the first pilot centre authorized. All deceased patients in our 16 beds intensive care Unit (ICU) were prospectively enrolled into a national database transplant information system run by the Agence de la biomedicine (ABM). We identified reasons why a possible donor did not become a utilized donor in accordance with WHO Critical Pathway for deceased donors [1]. This article is protected by copyright...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29928775/perfusion-settings-and-additives-in-liver-normothermic-machine-perfusion-with-red-blood-cells-as-oxygen-carrier-a-systematic-review-of-human-and-porcine-perfusion-protocols
#12
REVIEW
Dilmurodjon Eshmuminov, Filippo Leoni, Marcel André Schneider, Dustin Becker, Xavier Muller, Christopher Onder, Max Hefti, Martin Schuler, Philipp Dutkowski, Rolf Graf, Philipp Rudolf von Rohr, Pierre-Alain Clavien, Lucia Bautista Borrego
Liver machine perfusion at normothermic temperature (NMP) is a promising way to preserve and evaluate extended criteria donor livers. Currently, no consensus exists in methodology and perfusion protocols. Here, the authors performed a systematic literature search to identify human and porcine studies reporting on liver NMP with red blood cells. A qualitative synthesis was performed concerning technical aspects of machine perfusion, fluid composition, gas supply and liver positioning. 37 publications including 11 human and 26 porcine studies were considered for qualitative synthesis...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29928768/high-altitude-trekking-after-lung-transplantation-a-prospective-study-using-lung-ultrasound-to-detect-comets-tails-for-interstital-pulmonary-edema-in-lung-transplant-recipients-and-healthy-volunteers
#13
Ulrike Weber, Judith Schiefer, Jakob Mühlbacher, Martin Hermann Bernardi, Clemens Maria Ortner, Peter Jaksch
The intensity of physical activity which can be tolerated after lung transplantation and the tolerance to prolonged exercise at high altitude are poorly investigated. Lung ultrasound comet tails have been used in the diagnosis of interstitial pulmonary edema and high pulmonary altitude edema. The aim was to asses the number of lung ultrasound comet tails and to monitor changes in the optic nerve sheath diameter (ONSD) during a climb to the top of Mount Kilimanjaro in 10 lung transplant recipients and 10 healthy controls at three different altitude levels: 1360m, 3505m, 4900m...
June 21, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29908082/the-role-of-sigma-1-receptor-in-sex-specific-heat-shock-response-in-an-experimental-rat-model-of-renal-ischaemia-reperfusion-injury
#14
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischaemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischaemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907979/predicting-future-citation-counts-of-scientific-manuscripts-submitted-for-publication-a-cohort-study-in-transplantology
#15
Michael Kossmeier, Georg Heinze
MAIN PROBLEM: Citations are widely used for measuring scientific impact. The goal of the present study is to predict citation counts of manuscripts submitted to Transplant International (TI) in the two calendar years following publication. METHODS: We considered a comprehensive set of 21 manuscript, author, and peer review related predictor variables available early in the peer review process. We also evaluated how successfully the peer-review process at TI identified and accepted the most promising manuscripts for publication...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29907976/outcomes-of-domino-liver-transplantation-compared-to-deceased-donor-liver-transplantation-a-propensity-matching-approach
#16
Emily D Geyer, Candice Burrier, Dmitry Tumin, Don Hayes, Sylvester M Black, W Kenneth Washburn, Joseph D Tobias
Domino liver transplantation (DLT) utilizes the explanted liver of one liver transplant recipient as a donor graft in another patient. While there may be unique risks associated with DLT, it is unclear if DLT has less favorable long-term outcomes than deceased donor liver transplantation (DDLT). We used a propensity score matching approach to compare the outcomes of DLT recipients to DDLT recipients. The United Network for Organ Sharing (UNOS) registry was queried for patients undergoing DLT or DDLT in 2002-2016...
June 15, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29893433/the-1-year-renal-biopsy-index-1-rbi-a-scoring-system-to-drive-biopsy-indication-at-1-year-post-kidney-transplantation
#17
REVIEW
Magali Giral, Karine Renaudin, Maarten Naesens, Redmer Luning, Dany Anglicheau, Emmanuel Morelon, Alexandre Huneau, Chloé Paul, Sophie Brouard, Grégoire Couvrat-Desvergnes, Yohann Foucher, Etienne Dantan
Surveillance biopsies after renal transplantation remain debatable. To drive the decision of such intervention, we propose a predictive score of abnormal histology at 1-year post-transplantation, named 1-Year Renal Biopsy Index (1-RBI). We studied 466 kidney recipients from the DIVAT cohort alive with a functioning graft and a surveillance biopsy at 1-year post-transplantation. Patients displaying abnormal histology (49%) (borderline, acute rejection, IFTA grade 2 or 3, glomerulonephritis) were compared to the normal or subnormal (IFTA grade 1) histology group...
June 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29885002/heart-re-transplantation-in-eurotransplant
#18
Jacqueline M Smits, Michel De Pauw, Uwe Schulz, Johan Van Cleemput, Philip Raake, Ivan Knezevic, Kadir Caliskan, Zeljko Sutlic, Christoph Knosalla, Felix Schoenrath, Zoltan Szabolcs, Jens Gottlieb, Christian Hagl, Andreas Doesch, Davor Baric, Igor Rudez, Agita Strelniece, Erwin De Vries, Dave Green, Undine Samuel, Davor Milicic, Istvan Hartyanszky, Michael Berchtold-Herz, P Christian Schulze, Friedrich Mohr, Bruno Meiser, Axel Haverich, Hermann Reichenspurner, Jan Gummert, Guenter Laufer, Andreas Zuckermann
Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era...
June 8, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29856511/atrial-changes-after-kidney-transplant-what-diagnostic-and-therapeutic-perspectives
#19
Gaetano La Manna, Irene Capelli
Kidney transplant is known to be the first choice therapy for end stage chronic kidney disease, also for its positive effects on kidney transplant recipients cardiovascular morbidity and mortality. Several evidences evaluated the morphological changes of the left ventricle before and after transplantation, demonstrating a positive effect of at least partial regression of left ventricular hypertrophy (LVH) in kidney transplant recipients. This article is protected by copyright. All rights reserved.
June 1, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29855106/isolated-v-lesion-represents-a-benign-phenotype-of-vascular-rejection-of-the-kidney-allograft-a-retrospective-study
#20
Marek Novotny, Petra Hruba, Petra Vichova, Jana Maluskova, Eva Honsova, Ondrej Viklicky, Mariana Wohlfahrtova
While the detrimental impact of the humoral acute vascular rejection (AVR) phenotype is recognized, the prognostic significance of isolated v-lesion (IV) remains unclear. In this retrospective single-centre study, AVR was found in 98 of 1015 patients (9.7%) who had undergone kidney transplantation in 2010-2014, with donor-specific antibodies (DSA) evaluated in all of them. The outcome of four AVR phenotypes was evaluated during median follow-up of 59 months; in 25 patients with IV, 18 with T-cell-mediated vascular rejection (TCMVR), 19 with antibody-mediated vascular rejection (AMVR) and 36 with suspected antibody-mediated rejection (sAMVR)...
May 31, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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