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Transplant International: Official Journal of the European Society for Organ Transplantation

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https://www.readbyqxmd.com/read/30411406/apolipoprotein-a-ib-as-a-biomarker-of-fsgs-recurrence-after-kidney-transplantation-diagnostic-performance-and-assessment-of-its-prognostic-value-a-multi-centre-cohort-study
#1
Natàlia Puig-Gay, Conxita Jacobs-Cacha, Joana Sellarès, Lluís Guirado, Francisco González Roncero, Carlos Jiménez, Sofía Zárraga, Javier Paul, Ricardo Lauzurica, Alonso Ángel, Ana Fernández, Isabel Beneyto, Auxiliadora Mazuecos, Domingo Hernández, Alberto Rodriguez-Benot, Antonio Franco, Luisa Jimeno, Marta Crespo, Anna Meseguer, Francesc Moreso, Daniel Seron, Joan Lopez-Hellin, Carmen Cantarell
Recurrence of idiopathic FSGS is a serious complication after kidney transplantation. FSGS relapse is suspected by a sudden increase in proteinuria but there is not an accurate non-invasive diagnostic tool to confirm this entity or to detect patients at risk. We aimed to validate the diagnostic performance of ApoA-Ib to detect FSGS relapses by measuring urinary ApoA-Ib in a retrospective cohort of 61 kidney transplanted patients (37 FSGS and 24 non-FSGS). In addition, to assess the ApoA-Ib predictive ability, ApoA-Ib was measured periodically in a prospective cohort of 13 idiopathic FSGS patients who were followed during one year after transplantation...
November 8, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30395360/microvascular-inflammation-in-renal-allograft-biopsies-assessed-by-endothelial-and-leukocyte-co-immunostain-a-retrospective-study-on-reproducibility-and-clinical-prognostic-correlates
#2
Marco Delsante, Umberto Maggiore, Jonathan Levi, David E Kleiner, Annette M Jackson, Lois J Arend, Stephen M Hewitt, Naima Carter-Monroe, Serena M Bagnasco, Avi Z Rosenberg
The most prominent histologic lesion in antibody-mediated rejection is microvascular inflammation (MVI), however its recognition and scoring can be challenging and poorly reproducible between pathologists. We developed a dual immunohistochemical (IHC)-stain (anti-CD34/anti-CD45 for endothelium/leukocytes) as ancillary tool to improve on the semi-quantitative Banff scores and allow quantification of MVI. We examined the relationship between CD34-CD45 IHC-based quantitative MVI score (the inflamed peritubular capillary ratio, iptcr) and renal-graft failure or DSA strength at the time of biopsy...
November 5, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30387910/vascularized-composite-allotransplantation-a-council-of-europe-position-paper
#3
REVIEW
Marie Thuong, Palmina Petruzzo, Luis Landin, Beatriz Mahillo, Simon Kay, Sylvie Testelin, Jerzy Jablecki, Karim Laouabdia-Sellami, Marta Lopez Fraga, Beatriz Dominguez-Gil
Hand/upper extremity and face transplantation has rapidly evolved over the last few years, with the current need of standardizing and regulating the practice. The European Union Health Authorities on organ donation and transplantation have widely discussed the appropriate regulatory classification for allogeneic vascularized composite tissue, with the agreement that these grafts should fall under Directive 2010/53/EU of the European Parliament and of the Council on quality and safety standards of human organs intended for transplantation...
November 2, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30362294/renoportal-anastomosis-in-liver-transplantation-and-its-impact-on-patient-outcomes-a-systematic-literature-review
#4
REVIEW
G D'Amico, A Hassan, T DiagoUso, C C Lindenmeyer, K Hashmimoto, F N Aucejo, M Fujiki, B Eghtesad, K Sasaki, C M Miller, C Quintini
INTRODUCTION: Portal vein thrombosis (PVT) is commonly encountered during liver transplantation (LT). Depending on the grade of thrombosis, varied management strategies are indicated. The aims of this study are to clarify the contemporary role of reno-portal anastomosis (RPA) in patients with splanchnic vein thrombosis (SVT) undergoing LT and to systematically analyze all reported cases of RPA. MATERIALS AND METHODS: A systematic literature search was performed according to Preferred Reporting Items for Systematic Reviews and Meta- Analyses statement guidelines...
October 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30357927/urinary-proteomics-to-diagnose-chronic-active-antibody-mediated-rejection-in-pediatric-kidney-transplantation-a-pilot-study
#5
Nele Kirsten Kanzelmeyer, Petra Zürbig, Harald Mischak, Jochen Metzger, Alexander Fichtner, Kristzina Heindl Ruszai, Tomas Seemann, Matthias Hansen, Simone Wygoda, Kai Krupka, Burkhard Tönshoff, Anette Melk, Lars Pape
Chronic antibody-mediated rejection (cABMR) is the main cause of long-term renal graft loss. Late-stage diagnosis is made by detecting donor-specific antibodies (DSA) in blood combined with typical histomorphological lesions in renal allografts. There is a need for non-invasive biomarkers for cABMR that might permit screening and earlier diagnosis. In a case control study of 24 pediatric renal transplant recipients urine samples were analyzed using capillary electrophoresis and mass spectrometry. Patients were matched with 36 pediatric renal transplant patients without cABMR...
October 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30353584/pre-and-post-donation-kidney-function-in-donors-of-a-kidney-paired-donation-with-unique-criteria-for-donor-glomerular-filtration-rate-a-longitudinal-cohort-analysis
#6
Jenny Hc Chen, Peter Hughes, Claudia Woodroffe, Paolo Ferrari
Baseline pre-donation eGFR appears to predict the risk of post-donation chronic kidney disease in live donors. New KIDGO guidelines recommend an eGFR ≥90ml/min/1.73m2 as an acceptable level of GFR for kidney donation. In the Australian Paired Kidney Exchange (AKX) program, all donors with a raw measured GFR (mGFR) ≥80ml/min are deemed suitable for donation, but the significance of this selection indicator is unclear. We analysed the first 129 live donors in the AKX program with at least 1-year follow-up linking records in the AKX database and ANZDATA...
October 24, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30353611/assessment-of-simple-indices-based-on-a-single-fasting-blood-sample-as-a-tool-to-estimate-beta-cell-function-after-total-pancreatectomy-with-islet-autotransplantation-a-prospective-study
#7
Justyna E Gołębiewska, Piotr J Bachul, Natalie Fillman, Lindsay Basto, Mark R Kijek, Karolina Gołąb, Ling-Jia Wang, Martin Tibudan, Celeste Thomas, Alicja Dębska-Ślizień, Andres Gelrud, Jeffrey B Matthews, J Michael Millis, John Fung, Piotr Witkowski
We investigated six indices based on a single fasting blood sample for evaluation of the beta-cell function after total pancreatectomy with islet autotransplantation (TP-IAT). The Secretory Unit of Islet Transplant Objects (SUITO), transplant estimated function (TEF), homeostasis model assessment (HOMA)2-B%, C-peptide/glucose ratio (CP/G), C-peptide/glucose creatinine ratio (CP/GCr) and BETA-2 score were compared against a 90-min serum glucose level, weighted mean C-peptide in mixed meal tolerance test (MMTT), beta-score and the Igls score adjusted for islet function in the setting of IAT...
October 23, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30350898/reply-to-association-between-donor-age-and-risk-of-graft-failure-after-liver-transplantation-an-analysis-of-the-eurotransplant-database-a-retrospective-cohort-study
#8
LETTER
Davide Ghinolfi, Quirino Lai, Paolo De Simone
We read with great interest the study by Pratschke et al. "Association between donor age and risk of graft failure after liver transplantation: An analysis of the Eurotransplant database - a retrospective cohort study". The study analyzed a large dataset from Eurotransplant and included a final sample of 8,351 patients undergoing liver transplantation between January 2000 and July 2014, of whom 252 (3.0%) were transplanted with octogenarian, brain-dead donor grafts. Unfortunately, the paper raises several concerns from a methodological point of view...
October 23, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30350894/extended-criteria-donor-lung-reconditioning-with-the-organ-care-system-lung-a-single-institution-experience
#9
Marco Schiavon, Giulio Faggi, Alessandro Rebusso, Francesca Lunardi, Giovanni Comacchio, Guido Di Gregorio, Paolo Feltracco, Dario Gregori, Fiorella Calabrese, Giuseppe Marulli, Emanuele Cozzi, Federico Rea
OBJECTIVE: Lung transplantation is a life-saving procedure limited by donor's availability. Lung reconditioning by Ex Vivo Lung Perfusion represents a tool to expand the donor pool. In this study, we describe our experience with the OCS™ Lung to assess and recondition extended criteria lungs. METHODS: From January 2014 to October 2016, out of 86 on-site donors evaluated, 8 lungs have been identified as potentially treatable with OCS™ Lung. We analyzed data from these donors and the recipient outcomes after transplantation...
October 23, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30341790/the-long-and-winding-road-towards-epitope-matching-in-clinical-transplantation
#10
REVIEW
Cynthia Kramer, Moshe Israeli, Arend Mulder, Ilias Doxiadis, Geert Haasnoot, Sebastiaan Heidt, Frans Claas
Recent data suggest that HLA epitope matching is beneficial for the prevention of de novo donor specific antibody (DSA) formation after transplantation. In this review, different approaches to predict the immunogenicity of an HLA mismatch will be discussed. The parameters used in these models are often called epitopes but the actual antibody epitope is far more complex. Exact knowledge of the antibody epitope is crucial if epitope matching is also used as a tool to select compatible donors for (highly) sensitized patients...
October 19, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30318858/effects-of-remote-ischemic-preconditioning-on-intraportal-islet-transplantation-in-a-rat-model
#11
Vaihere Delaune, Stéphanie Lacotte, Quentin Gex, Florence Slits, Arianna Kahler-Quesada, Vanessa Lavallard, Andrea Peloso, Lorenzo A Orci, Thierry Berney, Christian Toso
Remote ischemic preconditioning (RIPC), which is the intermittent interruption of blood flow to a site distant from the target organ, is known to improve solid organ resistance to ischemia-reperfusion injury. This procedure could be of interest in islet transplantation to mitigate hypoxia-related loss of islet mass after isolation and transplantation. Islets isolated from control or RIPC donors were analyzed for yield, metabolic activity, gene expression and high mobility group box-1 (HMGB1) content. Syngeneic marginal mass transplantation was performed in four streptozotocin-induced diabetic groups: control, RIPC in donor only, RIPC in recipient only, and RIPC in donor and recipient...
October 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30315726/a-novel-customized-3d-printed-perfusion-chamber-for-normothermic-machine-perfusion-of-the-kidney
#12
LETTER
Ahmer Hameed, Suat Dervish, Natasha Rogers, Henry Pleass, Wayne Hawthorne
No abstract text is available yet for this article.
October 13, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30260509/association-between-donor-age-and-risk-of-graft-failure-after-liver-transplantation-an-analysis-of-the-eurotransplant-database
#13
Sebastian Pratschke, Andreas Bender, Florian Boesch, Joachim Andrassy, Marieke van Rosmalen, Undine Samuel, Xavier Rogiers, Bruno Meiser, Helmut Küchenhoff, David Driesslein, Jens Werner, Markus Guba, Martin K Angele
Grafts from elderly donors are increasingly used for liver transplantation. As of yet there is no published systematic data to guide the use of specific age cutoffs the effect of elderly donors on patient outcomes must be clarified. This study analyzed the Eurotransplant database (01/01/2000-31/07/2014; N = 26 294) out of whom 8341 liver transplantations were filtered to identify for this analysis. 2162 of the grafts came from donors >60 including 203 from octogenarians ≥80 years. Primary outcome was the risk of graft failure according to donor age using a confounder adjusted Cox-Regression model with frailty terms (or random effects)...
September 27, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30259574/2018-annual-report-of-the-european-liver-transplant-registry-eltr-50-year-evolution-of-liver-transplantation
#14
René Adam, Vincent Karam, Valérie Cailliez, John G O Grady, Darius Mirza, Daniel Cherqui, Jurgen Klempnauer, Mauro Salizzoni, Johann Pratschke, Neville Jamieson, Ernest Hidalgo, Andreas Paul, Rafael Lopez Andujar, Jan Lerut, Lutz Fisher, Karim Boudjema, Constantino Fondevila, Olivier Soubrane, Philippe Bachellier, Antonio D Pinna, Gabriela Berlakovich, William Bennet, Massimo Pinzani, Peter Schemmer, Krzysztof Zieniewicz, Carlos Jimenez Romero, Paolo De Simone, Bo-Goran Ericzon, Stefan Schneeberger, Stephen J Wigmore, Joan Fabregat Prous, Michele Colledan, Robert J Porte, Sezai Yilmaz, Daniel Azoulay, Jacques Pirenne, Pal-Dag Line, Pavel Trunecka, Francis Navarro, Andres Valdivieso Lopez, Luciano De Carlis, Sebastian Rufian Pena, Eberhard Kochs, Christophe Duvoux
The purpose of this registry study was to provide an overview of trends and results of liver transplantation in Europe from 1968 to 2016. This data on liver transplantation (LT) was collected prospectively from 169 centers from 32 countries, in the European Liver Transplant Registry (ELTR) beginning in 1968. This overview provides epidemiological data, as well as information on evolution of techniques, and outcomes in liver transplantation in Europe over more than 5 decades; something that cannot be obtained from only a single center experience...
September 26, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30252957/high-tacrolimus-clearance-a-risk-factor-for-development-of-interstitial-fibrosis-and-tubular-atrophy-in-the-transplanted-kidney-a-retrospective-single-center-cohort-study
#15
Erlend Johannessen Egeland, Anna Varberg Reisaeter, Ida Robertsen, Karsten Midtvedt, Erik Heyerdahl Strøm, Hallvard Holdaas, Anders Hartmann, Anders Åsberg
BACKGROUND: Patients with high tacrolimus clearance are more likely to experience transient under-immunosuppression in case of a missed or delayed dose. We wanted to investigate the association between estimated tacrolimus clearance and development of graft interstitial fibrosis and tubular atrophy (IFTA) in kidney transplant recipients. METHODS: Associations between estimated tacrolimus clearance (daily tacrolimus dose [mg] / trough concentration [μg/L]) and changes in IFTA biopsy scores from week 7 to 1 year post-transplantation were investigated...
September 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30251360/cold-flush-after-dynamic-liver-preservation-protects-against-ischemic-changes-upon-reperfusion-an-experimental-study
#16
Charlotte von Horn, Patrick Hannaert, Thierry Hauet, Henri Leuvenink, Andreas Paul, Thomas Minor
Ex vivo machine perfusion of the liver after cold storage has found to be most effective if combined with controlled oxygenated rewarming (COR) up to (sub)-normothermia. Upon disconnection of the warm graft from the machine most surgeons usually perform a cold flush of the organ as protection against the 2nd warm ischemia incurred upon implantation. Experimental evidence however is lacking and protective effect of deep hypothermia has been challenged for limited periods of liver ischemia in other models. A first systematic test was carried out on porcine livers, excised 30 minutes after cardiac arrest, subjected to 18 hours of cold storage in UW and then machine-perfused for 90 minutes with Aqix-RSI solution...
September 25, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30244519/the-relevance-of-donor-satisfaction-after-living-kidney-donation-a-plea-for-a-routine-psychosocial-follow-up
#17
Sylvia Kroencke
In living kidney donation (LKD), the donor agrees to undergo an elective procedure for the benefit of the recipient. Therefore, it is imperative to provide living donors with optimal care, both before and after LKD. Follow-up should be rigorous, long-term, and focus not only on medical but also on psychosocial outcome. The latter additionally offers the opportunity to question donors about aspects they themselves regard as crucial for their well-being. This article is protected by copyright. All rights reserved...
September 23, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30238527/obesity-does-not-significantly-impact-outcomes-following-simultaneous-liver-kidney-transplantation-review-of-the-unos-database-a-retrospective-study
#18
Jonathan W Yu, Gaurav Gupta, Le Kang, Dipankar Bandyopadhyay, Mohammed S Siddiqui, Chandra S Bhati, Richard T Stravitz, Marlon Levy, Trevor W Reichman
Simultaneous liver kidney transplantation (SLK) is the only curative option for patients with combined end stage liver and kidney disease. With the global obesity epidemic, an increasing number of obese patients are in need of SLK. However, the impact of pre-transplant obesity on outcomes after SLK is unknown. An analysis of the United States OPTN registry (Oct 1987 - June 2016) identified 7205 SLK transplants. Of these, 1677 patients were overweight/obese (OW, BMI 30-39) and 183 were morbidly obese (MO, BMI ≥40)...
September 20, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30230053/mortality-in-liver-transplant-recipients-with-portal-vein-thrombosis-an-updated-meta-analysis
#19
Alberto Zanetto, Krissia-Isabel Rodriguez-Kastro, Giacomo Germani, Alberto Ferrarese, Umberto Cillo, Patrizia Burra, Marco Senzolo
Portal vein thrombosis (PVT) is the most common thrombotic event in liver transplant (LT) recipients, but its impact on mortality after LT has been analyzed in heterogeneous cohorts with mixed results. To conduct a meta-analysis on the impact of PVT on post-LT survival. A systematic search was conducted on studies (published from January 1986 to January 2018) that reported 30-day and 1-year mortality after LT of PVT patients. Four hundred twenty-seven articles were reviewed and 44 were included. Among 98 558 LT, 7257 (7...
September 19, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30198148/dynamics-of-early-post-operative-plasma-ddcfdna-levels-in-kidney-transplantation-a-single-center-pilot-study
#20
Jia Shen, Yang Zhou, Yawen Chen, Xiaofeng Li, Wenhua Lei, Jun Ge, Wenhan Peng, Jianyong Wu, Guangjun Liu, Gongda Yang, Haifeng Shi, Jianghua Chen, Tingya Jiang, Rending Wang
Donor-derived cell-free DNA (ddcfDNA) is reported to be a promising noninvasive biomarker for acute rejection in organ transplant. However, studies on monitoring ddcfDNA dynamics during the early periods after organ transplantation are scarce. Our study assessed the dynamic variation in ddcfDNA in early period with various types and status of kidney transplantation. Target region capture sequencing used identifies ddcfDNA level in 21 kidney transplant recipients. Median ddcfDNA level was 20.69% at the initial time post-transplant, and decreased to 5...
September 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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