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Psychological Medicine

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https://www.readbyqxmd.com/read/28534464/does-the-social-functioning-scale-reflect-real-life-social-functioning-an-experience-sampling-study-in-patients-with-a-non-affective-psychotic-disorder-and-healthy-control-individuals
#1
M Schneider, U Reininghaus, M van Nierop, M Janssens, I Myin-Germeys
BACKGROUND: The ecological validity of retrospective measures of social functioning is currently unknown in patients with schizophrenia. In the present study, patients with a diagnosis of non-affective psychosis were compared with controls on two measures of social functioning: the Social Functioning Scale (SFS) and daily-life measures collected with the Experience Sampling Methodology (ESM). The associations between both measures were examined in each group of participants to test for the ecological validity of the SFS...
May 23, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28528597/adjunctive-memantine-for-schizophrenia-a-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#2
W Zheng, X-H Li, X-H Yang, D-B Cai, G S Ungvari, C H Ng, S-B Wang, Y-Y Wang, Y-P Ning, Y-T Xiang
BACKGROUND: Dysfunction of N-methyl-D-aspartate receptor (NMDAR) is involved in the pathophysiology of schizophrenia. A meta-analysis of randomized controlled trials (RCTs) was conducted to examine the efficacy and safety of memantine, a non-competitive NMDAR antagonist, in the treatment of schizophrenia. METHODS: Standardized/weighted mean differences (SMDs/WMDs), risk ratio (RR), and their 95% confidence intervals (CIs) were calculated and analyzed. RESULTS: Included in the meta-analysis were eight RCTs (n = 452) of 11...
May 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28528586/white-matter-connectivity-disruptions-in-early-and-chronic-schizophrenia
#3
M A Di Biase, V L Cropley, B T Baune, J Olver, G P Amminger, C Phassouliotis, C Bousman, P D McGorry, I Everall, C Pantelis, A Zalesky
BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalities differ between illness stages. We mapped the connectome in patients with recently diagnosed and chronic schizophrenia and investigated the extent and overlap of white matter connectivity disruptions between these illness stages. METHODS: Diffusion-weighted magnetic resonance images were acquired in recent-onset (n = 19) and chronic patients (n = 45) with schizophrenia, as well as age-matched controls (n = 87)...
May 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28528584/autism-risk-following-antidepressant-medication-during-pregnancy
#4
A Viktorin, R Uher, A Reichenberg, S Z Levine, S Sandin
BACKGROUND: Previous studies have examined if maternal antidepressant medication during pregnancy increase the risk of autism spectrum disorder (ASD) in the offspring, but the results have been conflicting. METHODS: In a population-based cohort of 179 007 children born in 2006 and 2007 and followed through 2014 when aged 7 and 8, we estimated relative risks (RRs) of ASD and 95% confidence intervals (CIs) from Cox regression in children exposed to any antidepressant medication during pregnancy, and nine specific antidepressant drugs...
May 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28521844/cognitive-reserve-as-a-moderator-of-the-negative-association-between-mood-and-cognition-evidence-from-a-population-representative-cohort
#5
C Opdebeeck, F E Matthews, Y-T Wu, R T Woods, C Brayne, L Clare
BACKGROUND: Cognitive reserve (CR) has been associated with better cognitive function and lower risk of depression in older people, yet it remains unclear whether CR moderates the association between mood and cognition. This study aimed to investigate whether a comprehensive indicator of CR, including education, occupation and engagement in cognitive and social activities, acts as a moderator of this association. METHODS: This was a cross-sectional study utilising baseline data from the Cognitive Function and Ageing Study II (CFAS II), a large population-based cohort of people aged 65+ in England...
May 19, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28511734/sleeping-with-one-eye-open-loneliness-and-sleep-quality-in-young-adults
#6
T Matthews, A Danese, A M Gregory, A Caspi, T E Moffitt, L Arseneault
BACKGROUND: Feelings of loneliness are common among young adults, and are hypothesized to impair the quality of sleep. In the present study, we tested associations between loneliness and sleep quality in a nationally representative sample of young adults. Further, based on the hypothesis that sleep problems in lonely individuals are driven by increased vigilance for threat, we tested whether past exposure to violence exacerbated this association. METHOD: Data were drawn from the Environmental Risk (E-Risk) Longitudinal Twin Study, a birth cohort of 2232 twins born in England and Wales in 1994 and 1995...
May 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28502265/psychological-autopsy-study-comparing-suicide-decedents-suicide-ideators-and-propensity-score-matched-controls-results-from-the-study-to-assess-risk-and-resilience-in-service-members-army-starrs
#7
M K Nock, C L Dempsey, P A Aliaga, D A Brent, S G Heeringa, R C Kessler, M B Stein, R J Ursano, D Benedek
BACKGROUND: The suicide rate has increased significantly among US Army soldiers over the past decade. Here we report the first results from a large psychological autopsy study using two control groups designed to reveal risk factors for suicide death among soldiers beyond known sociodemographic factors and the presence of suicide ideation. METHODS: Informants were next-of-kin and Army supervisors for: 135 suicide cases, 137 control soldiers propensity-score-matched on known sociodemographic risk factors for suicide and Army history variables, and 118 control soldiers who reported suicide ideation in the past year...
May 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28485261/ten-month-outcome-of-cognitive-behavioural-therapy-v-interpersonal-psychotherapy-in-patients-with-major-depression-a-randomised-trial-of-acute-and-maintenance-psychotherapy
#8
R Mulder, J Boden, J Carter, S Luty, P Joyce
BACKGROUND: Cognitive behaviour therapy (CBT) and interpersonal psychotherapy (IPT) are the most studied psychotherapies for treatment of depression, but they are rarely directly compared particularly over the longer term. This study compares the outcomes of patients treated with CBT and IPT over 10 months and tests whether there are differential or general predictors of outcome. METHODS: A single centre randomised controlled trial (RCT) of depressed outpatients treated with weekly CBT or IPT sessions for 16 weeks and then 24 weeks of maintenance CBT or IPT...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28485259/distinct-phasic-and-sustained-brain-responses-and-connectivity-of-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-panic-disorder
#9
L Brinkmann, C Buff, K Feldker, S V Tupak, M P I Becker, M J Herrmann, T Straube
BACKGROUND: Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD. METHODS: Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28485257/neurocognitive-deficits-in-schizophrenia-are-we-making-mountains-out-of-molehills
#10
S Moritz, J P Klein, T Desler, H Lill, J Gallinat, B C Schneider
BACKGROUND: Most original studies and all meta-analyses conducted to date converge on the conclusion that patients with schizophrenia display rather generalized neurocognitive deficits. For the present study, we reopen this seemingly closed chapter and examine whether important influences, such as lack of motivation and negative attitudes towards cognitive assessment, result in poorer secondary neuropsychological performance. METHOD: A sample of 50 patients with an established diagnosis of schizophrenia were tested for routine neurocognitive assessment and compared to 60 nonclinical volunteers...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28478783/genetic-and-other-risk-factors-for-suicidal-ideation-and-the-relationship-with-depression
#11
R Dutta, H A Ball, S H Siribaddana, A Sumathipala, S Samaraweera, P McGuffin, M Hotopf
BACKGROUND: There is a genetic contribution to the risk of suicide, but sparse prior research on the genetics of suicidal ideation. METHODS: Active and passive suicidal ideation were assessed in a Sri Lankan population-based twin registry (n = 3906 twins) and a matched non-twin sample (n = 2016). Logistic regression models were used to examine associations with socio-demographic factors, environmental exposures and psychiatric symptoms. The heritability of suicidal ideation was assessed using structural equation modelling...
May 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28478782/the-effect-of-heart-rate-variability-biofeedback-training-on-stress-and-anxiety-a-meta-analysis
#12
V C Goessl, J E Curtiss, S G Hofmann
BACKGROUND: Some evidence suggests that heart rate variability (HRV) biofeedback might be an effective way to treat anxiety and stress symptoms. To examine the effect of HRV biofeedback on symptoms of anxiety and stress, we conducted a meta-analysis of studies extracted from PubMed, PsycINFO and the Cochrane Library. METHODS: The search identified 24 studies totaling 484 participants who received HRV biofeedback training for stress and anxiety. We conducted a random-effects meta-analysis...
May 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28478767/veterans-with-post-traumatic-stress-disorder-exhibit-altered-emotional-processing-and-attentional-control-during-an-emotional-stroop-task
#13
M M Khanna, A S Badura-Brack, T J McDermott, C M Embury, A I Wiesman, A Shepherd, T J Ryan, E Heinrichs-Graham, T W Wilson
BACKGROUND: Post-traumatic stress disorder (PTSD) is often associated with attention allocation and emotional regulation difficulties, but the brain dynamics underlying these deficits are unknown. The emotional Stroop task (EST) is an ideal means to monitor these difficulties, because participants are asked to attend to non-emotional aspects of the stimuli. In this study, we used magnetoencephalography (MEG) and the EST to monitor attention allocation and emotional regulation during the processing of emotionally charged stimuli in combat veterans with and without PTSD...
May 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28470143/to-the-editor-how-statistics-killed-the-cat
#14
E F Torrey, R H Yolken
No abstract text is available yet for this article.
May 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28468693/neurocognitive-impairment-in-deficit-and-non-deficit-schizophrenia-a-meta-analysis
#15
E Bora, B Binnur Akdede, K Alptekin
BACKGROUND: Most studies suggested that patients with deficit schizophrenia have more severe impairment compared with patients with non-deficit schizophrenia. However, it is not clear whether deficit and non-deficit schizophrenia are associated with differential neurocognitive profiles. METHODS: The aim of this meta-analytic review was to compare cognitive performances of deficit and non-deficit patients with each other and with healthy controls. In the current meta-analysis, differences in cognitive abilities between 897 deficit and 1636 non-deficit patients with schizophrenia were examined...
May 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28464976/patterns-of-white-matter-microstructure-in-individuals-at-ultra-high-risk-for-psychosis-associations-to-level-of-functioning-and-clinical-symptoms
#16
K Krakauer, B H Ebdrup, B Y Glenthøj, J M Raghava, D Nordholm, L Randers, E Rostrup, M Nordentoft
BACKGROUND: Individuals at ultra-high-risk (UHR) for psychosis present with emerging symptoms and decline in functioning. Previous univariate analyses have indicated widespread white matter (WM) aberrations in multiple brain regions in UHR individuals and patients with schizophrenia. Using multivariate statistics, we investigated whole brain WM microstructure and associations between WM, clinical symptoms, and level of functioning in UHR individuals. METHODS: Forty-five UHR individuals and 45 matched healthy controls (HCs) underwent magnetic resonance diffusion tensor imaging (DTI) at 3 Tesla...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28464975/the-specific-effect-of-systematic-exposure-in-irritable-bowel-syndrome-complier-average-causal-effect-analysis-using-growth-mixture-modeling
#17
H Hesser, E Hedman, P Lindfors, E Andersson, B Ljótsson
BACKGROUND: We reanalyzed data from a previously published randomized component study that aimed to test the incremental effect of systematic exposure in an internet-delivered cognitive behavioral treatment (ICBT) for irritable bowel syndrome (IBS). METHODS: Three hundred and nine individuals with IBS were randomly assigned to either the full treatment protocol (experimental condition) or the same treatment protocol without systematic exposure (control). Participants were assessed weekly for IBS symptoms over the active treatment phase...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28464974/altered-activation-of-the-ventral-striatum-under-performance-related-observation-in-social-anxiety-disorder
#18
M P I Becker, D Simon, W H R Miltner, T Straube
BACKGROUND: Social anxiety disorder (SAD) is characterized by fear of social and performance situations. The consequence of scrutiny by others for the neural processing of performance feedback in SAD is unknown. METHODS: We used event-related functional magnetic resonance imaging to investigate brain activation to positive, negative, and uninformative performance feedback in patients diagnosed with SAD and age-, gender-, and education-matched healthy control subjects who performed a time estimation task during a social observation condition and a non-social control condition: while either being monitored or unmonitored by a body camera, subjects received performance feedback after performing a time estimation that they could not fully evaluate without external feedback...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28464965/risk-of-transition-to-schizophrenia-following-first-admission-with-substance-induced-psychotic-disorder-a-population-based-longitudinal-cohort-study
#19
H L Alderson, D M Semple, C Blayney, F Queirazza, V Chekuri, S M Lawrie
BACKGROUND: The potential for drugs of abuse to induce acute psychotic symptoms is well recognised. However, the likelihood of transition from initial substance-induced psychotic disorder (SIPD) to chronic psychosis is much less well understood. This study investigated the rate of SIPD transition to schizophrenia (F20), the time to conversion and other possible related factors. METHODS: Using data from the Scottish Morbidity Record, we examined all patients (n = 3486) since their first admission to psychiatric hospital with a diagnosis of SIPD [International Classification of Diseases, Tenth Revision (ICD-10) codes F10-F19, with third digit five] from January 1997 to July 2012...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28464963/modafinil-and-cognitive-enhancement-in-schizophrenia-and-healthy-volunteers-the-effects-of-test-battery-in-a-randomised-controlled-trial
#20
J Lees, P G Michalopoulou, S W Lewis, S Preston, C Bamford, T Collier, A Kalpakidou, T Wykes, R Emsley, G Pandina, S Kapur, R J Drake
BACKGROUND: Cognitive deficits in schizophrenia have major functional impacts. Modafinil is a cognitive enhancer whose effect in healthy volunteers is well-described, but whose effects on the cognitive deficits of schizophrenia appear to be inconsistent. Two possible reasons for this are that cognitive test batteries vary in their sensitivity, or that the phase of illness may be important, with patients early in their illness responding better. METHODS: A double-blind, randomised, placebo-controlled single-dose crossover study of modafinil 200 mg examined this with two cognitive batteries [MATRICS Consensus Cognitive Battery (MCCB) and Cambridge Neuropsychological Test Automated Battery (CANTAB)] in 46 participants with under 3 years' duration of DSM-IV schizophrenia, on stable antipsychotic medication...
May 3, 2017: Psychological Medicine
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