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Psychological Medicine

Katherine Schaumberg, Andreas Jangmo, Laura M Thornton, Andreas Birgegård, Catarina Almqvist, Claes Norring, Henrik Larsson, Cynthia M Bulik
BACKGROUND: Transition across eating disorder diagnoses is common, reflecting instability of specific eating disorder presentations. Previous studies have examined temporal stability of diagnoses in adult treatment-seeking samples but have not uniformly captured initial presentation for treatment. The current study examines transitions across eating disorder diagnostic categories in a large, treatment-seeking sample of individuals born in Sweden and compares these transitions across two birth cohorts and from initial diagnosis...
June 18, 2018: Psychological Medicine
Fernanda Leite, Ângela Leite, Emanuela Rasini, Michela Gaiazzi, Laura Ribeiro, Franca Marino, Marco Cosentino
No abstract text is available yet for this article.
June 18, 2018: Psychological Medicine
Jessica Franzen, Kerstin Brinkmann, Guido H E Gendolla, Othman Sentissi
BACKGROUND: The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS: Twenty patients with major depressive disorder (MDD) and 20 control participants worked on a memory task under neutral, reward, and punishment instructions. Effort mobilization was operationalized as cardiovascular reactivity, while facial expressions were measured by facial electromyographic reactivity...
June 18, 2018: Psychological Medicine
Franco Scinicariello, Jennifer Przybyla, Yulia Carroll, John Eichwald, John Decker, Patrick N Breysse
BACKGROUND: Depression is a common and significant health problem. Hearing loss is the third most common chronic physical condition in the USA and might be a factor in depression. To determine whether hearing loss is associated with depressive symptoms in US adults ages 20-69 years. METHODS: National Health and Nutrition Examination Survey (NHANES) data (2011-2012) were used to assess the potential relationship between hearing loss and depression, in adults (20-69 years) who answered the Patient Health Questionnaire (PHQ-9) depression screening module, with pure tone audiometry measurements, and complete information on the co-variates data (n = 3316)...
June 18, 2018: Psychological Medicine
Taro Kishi, Toshikazu Ikuta, Yuki Matsui, Ken Inada, Yuki Matsuda, Kazuo Mishima, Nakao Iwata
BACKGROUND: Discontinuation of antipsychotics predisposes patients with remitted/stable first-episode psychosis (FEP) to a higher risk of relapse, but it remains unclear how long discontinuation increases the relapse rate in these patients compared with maintenance. METHODS: This meta-analysis of randomized controlled trials (RCTs) compared relapse rates in FEP patients between antipsychotic treatment discontinuation and maintenance groups at 1, 2, 3, 6, 9, 12 (primary), and 18-24 months...
June 18, 2018: Psychological Medicine
Christine Mauro, Charles F Reynolds, Andreas Maercker, Natalia Skritskaya, Naomi Simon, Sidney Zisook, Barry Lebowitz, Stephen J Cozza, M Katherine Shear
BACKGROUND: The World Health Organization (WHO) International Classification of Disease (ICD-11) is expected to include a new diagnosis for prolonged grief disorder (ICD-11PGD). This study examines the validity and clinical utility of the ICD-11PGD guideline by testing its performance in a well-characterized clinical sample and contrasting it with a very different criteria set with the same name (PGDPLOS). METHODS: We examined data from 261 treatment-seeking participants in the National Institute of Mental Health (NIMH)-sponsored multicenter clinical trial to determine the rates of diagnosis using the ICD-11PGD guideline and compared these with diagnosis using PGDPLOS criteria...
June 18, 2018: Psychological Medicine
Jiao Li, Xujun Duan, Qian Cui, Huafu Chen, Wei Liao
BACKGROUND: Major depressive disorder (MDD) is associated with high risk of suicide. Conventional neuroimaging works showed abnormalities of static brain activity and connectivity in MDD with suicidal ideation (SI). However, little is known regarding alterations of brain dynamics. More broadly, it remains unclear whether temporal dynamics of the brain activity could predict the prognosis of SI. METHODS: We included MDD patients (n = 48) with and without SI and age-, gender-, and education-matched healthy controls (n = 30) who underwent resting-state functional magnetic resonance imaging...
June 18, 2018: Psychological Medicine
Travis E Baker, Natalie Castellanos-Ryan, Gunter Schumann, Anna Cattrell, Herta Flor, Frauke Nees, Tobias Banaschewski, Arun Bokde, Rob Whelan, Christian Buechel, Uli Bromberg, Dimitri Papadopoulos Orfanos, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Henrik Walter, Rüdiger Brühl, Penny Gowland, Tomáš Paus, Luise Poustka, Jean-Luc Martinot, Herve Lemaitre, Eric Artiges, Marie-Laure Paillère Martinot, Michael N Smolka, Patricia Conrod
BACKGROUND: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. METHODS: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic polymorphisms of the D1 and D2 receptor type on the reward function of the ventral striatum (VS) and orbital frontal cortex (OFC), and whether this relationship predicted the propensity to engage in early alcohol misuse behaviors at 14 years of age and again at 16 years of age...
June 18, 2018: Psychological Medicine
Jan Terock, Anke Hannemann, Deborah Janowitz, Harald J Freyberger, Stephan B Felix, Marcus Dörr, Matthias Nauck, Henry Völzke, Hans J Grabe
BACKGROUND: Previous studies suggested that exposure to traumatic events during childhood and adulthood and post-traumatic stress disorder (PTSD) are associated with a dysregulation of different neuroendocrine systems. However, the activity of the renin-angiotensin-aldosterone-system (RAAS) in relation to trauma/PTSD has been largely neglected. METHODS: Traumatization, PTSD, and plasma concentrations of renin and aldosterone were measured in 3092 individuals from the general population...
June 18, 2018: Psychological Medicine
K S Mitchell, E J Wolf, M J Lyons, J Goldberg, K M Magruder
No abstract text is available yet for this article.
June 18, 2018: Psychological Medicine
Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C Andrade, Morgana M Novaes, Jessica A Pessoa, Sergio A Mota-Rolim, Flávia L Osório, Rafael Sanches, Rafael G Dos Santos, Luís Fernando Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine, Jordi Riba, Francisco R Santos, Antonio A Silva-Junior, João C Alchieri, Nicole L Galvão-Coelho, Bruno Lobão-Soares, Jaime E C Hallak, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B Araújo
BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing...
June 15, 2018: Psychological Medicine
Merijn Eikelenboom, Aartjan T F Beekman, Brenda W J H Penninx, Johannes H Smit
BACKGROUND: Major depressive disorder (MDD), represent a major source of risk for suicidality. However, knowledge about risk factors for future suicide attempts (SAs) within MDD is limited. The present longitudinal study examined a wide range of putative non-clinical risk factors (demographic, social, lifestyle, personality) and clinical risk factors (depressive and suicidal indicators) for future SAs among persons with MDD. Furthermore, we examined the relationship between a number of significant predictors and the incidence of a future SA...
June 13, 2018: Psychological Medicine
Erika J Wolf, Mark W Logue, Filomene G Morrison, Elizabeth S Wilcox, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Posttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-sectionally associated with advanced DNA methylation age relative to chronological age. However, longitudinal inquiry and examination of associations between advanced DNA methylation age and a broader range of psychiatric disorders is lacking. The aim of this study was to examine if PTSD, depression, generalized anxiety, and alcohol-use disorders predicted acceleration of DNA methylation age over time (i...
June 13, 2018: Psychological Medicine
Imke L J Lemmers-Jansen, Anne-Kathrin J Fett, Esther Hanssen, Dick J Veltman, Lydia Krabbendam
BACKGROUND: Psychosis is characterized by problems in social functioning that exist well before illness onset, and in individuals at clinical high risk (CHR) for psychosis. Trust is an essential element for social interactions that is impaired in psychosis. In the trust game, chronic patients showed reduced baseline trust, impaired response to positive social feedback, and attenuated brain activation in reward and mentalizing areas. We investigated whether first-episode psychosis patients (FEP) and CHR show similar abnormalities in the neural and behavioral mechanisms underlying trust...
June 13, 2018: Psychological Medicine
Steven Hope, Anna Pearce, Catherine Chittleborough, Jessica Deighton, Amelia Maika, Nadia Micali, Murthy Mittinty, Catherine Law, John Lynch
BACKGROUND: Psychological distress is common among women of childbearing age, and limited longitudinal research suggests prolonged exposure to maternal distress is linked to child mental health problems. Estimating effects of maternal distress over time is difficult due to potential influences of child mental health problems on maternal distress and time-varying confounding by family circumstances. METHODS: We analysed the UK Millennium Cohort Study, a nationally representative sample with data collected throughout childhood...
June 11, 2018: Psychological Medicine
Margherita Malanchini, Emily Smith-Woolley, Ziada Ayorech, Kaili Rimfeld, Eva Krapohl, Eero Vuoksimaa, Tellervo Korhonen, Meike Bartels, Toos C E M van Beijsterveldt, Richard J Rose, Sebastian Lundström, Henrik Anckarsäter, Jaakko Kaprio, Paul Lichtenstein, Dorret I Boomsma, Robert Plomin
BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence...
June 11, 2018: Psychological Medicine
Rebecca Waller, Laura Murray, Daniel S Shaw, Erika E Forbes, Luke W Hyde
BACKGROUND: Alcohol use is commonly initiated during adolescence, with earlier onset known to increase the risk for alcohol use disorder (AUD). Altered function in neural reward circuitry is thought to increase the risk for AUD. To test the hypothesis that adolescent alcohol misuse primes the brain for alcohol-related psychopathology in early adulthood, we examined whether adolescent alcohol consumption rates predicted reward responsivity in the ventral striatum (VS), and in turn, AUD symptoms in adulthood...
June 6, 2018: Psychological Medicine
Carolina Ziebold, David P Goldberg, Geoffrey M Reed, Fareed Minhas, Bushra Razzaque, Sandra Fortes, Rebeca Robles, Tai Pong Lam, Julio Bobes, Celso Iglesias, Hugo Cogo-Moreira, José Ángel García, Jair J Mari
BACKGROUND: A study conducted as part of the development of the Eleventh International Classification of Mental Disorders for Primary Health Care (ICD-11 PHC) provided an opportunity to test the relationships among depressive, anxious and somatic symptoms in PHC. METHOD: Primary care physicians participating in the ICD-11 PHC field studies in five countries selected patients who presented with somatic symptoms not explained by known physical pathology by applying a 29-item screening on somatic complaints that were under study for bodily stress disorder...
June 4, 2018: Psychological Medicine
Jessica A Hartmann, Barnaby Nelson, Aswin Ratheesh, Devi Treen, Patrick D McGorry
Identifying young people at risk of developing serious mental illness and identifying predictors of onset of illness has been a focus of psychiatric prediction research, particularly in the field of psychosis. Work in this area has facilitated the adoption of the clinical staging model of early clinical phenotypes, ranging from at-risk mental states to chronic and severe mental illness. It has been a topic of debate if these staging models should be conceptualised as disorder-specific or transdiagnostic. In order to inform this debate and facilitate cross-diagnostic discourse, the present scoping review provides a broad overview of the body of literature of (a) longitudinal at-risk approaches and (b) identified antecedents of (homotypic) illness progression across three major mental disorders [psychosis, bipolar disorder (BD) and depression], and places these in the context of clinical staging...
June 4, 2018: Psychological Medicine
Tory A Eisenlohr-Moul, Katja M Schmalenberger, Sarah A Owens, Jessica R Peters, Danyelle N Dawson, Susan S Girdler
No abstract text is available yet for this article.
June 4, 2018: Psychological Medicine
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