Simone P Haller, Julia O Linke, Hannah L Grassie, Emily L Jones, David Pagliaccio, Anita Harrewijn, Lauren K White, Reut Naim, Rany Abend, Ajitha Mallidi, Erin Berman, Krystal M Lewis, Katharina Kircanski, Nathan A Fox, Wendy K Silverman, Ned H Kalin, Yair Bar-Haim, Melissa A Brotman
OBJECTIVE: Anxiety disorders are prevalent among youths and are often highly impairing. Cognitive-behavioral therapy (CBT) is an effective first-line treatment. The authors investigated the brain mechanisms associated with symptom change following CBT. METHODS: Unmedicated youths diagnosed with an anxiety disorder underwent 12 weeks of CBT as part of two randomized clinical trials testing the efficacy of adjunctive computerized cognitive training. Across both trials, participants completed a threat-processing task during functional MRI before and after treatment...
March 1, 2024: American Journal of Psychiatry