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American Journal of Psychiatry

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https://www.readbyqxmd.com/read/29792052/randomized-clinical-trial-of-computerized-and-clinician-delivered-cbt-in-comparison-with-standard-outpatient-treatment-for-substance-use-disorders-primary-within-treatment-and-follow-up-outcomes
#1
Brian D Kiluk, Charla Nich, Matthew B Buck, Kathleen A Devore, Tami L Frankforter, Donna M LaPaglia, Srinivas B Muvvala, Kathleen M Carroll
OBJECTIVE: Previous trials have demonstrated the efficacy and durability of computer-based cognitive-behavioral therapy (CBT4CBT) as an add-on to standard outpatient care in a range of treatment-seeking populations. In this study, the authors evaluated the efficacy and safety of CBT4CBT as a virtual stand-alone treatment, delivered with minimal clinical monitoring, and clinician-delivered cognitive-behavioral therapy (CBT) compared with treatment as usual in a heterogeneous sample of treatment-seeking outpatients with substance use disorders...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792051/predicting-suicide-attempts-and-suicide-deaths-following-outpatient-visits-using-electronic-health-records
#2
Gregory E Simon, Eric Johnson, Jean M Lawrence, Rebecca C Rossom, Brian Ahmedani, Frances L Lynch, Arne Beck, Beth Waitzfelder, Rebecca Ziebell, Robert B Penfold, Susan M Shortreed
OBJECTIVE: The authors sought to develop and validate models using electronic health records to predict suicide attempt and suicide death following an outpatient visit. METHOD: Across seven health systems, 2,960,929 patients age 13 or older (mean age, 46 years; 62% female) made 10,275,853 specialty mental health visits and 9,685,206 primary care visits with mental health diagnoses between Jan. 1, 2009, and June 30, 2015. Health system records and state death certificate data identified suicide attempts (N=24,133) and suicide deaths (N=1,240) over 90 days following each visit...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792050/risk-of-psychosis-in-recurrent-episodes-of-psychotic-and-nonpsychotic-major-depressive-disorder-a-systematic-review-and-meta-analysis
#3
J Craig Nelson, David Bickford, Kevin Delucchi, Jess G Fiedorowicz, William H Coryell
OBJECTIVE: The authors conducted a systematic review and meta-analysis to determine whether the risk of psychosis is higher in past or future episodes in patients with major depression with psychotic features than in patients with nonpsychotic depression. METHOD: PubMed, Embase, and PsycINFO were searched, and studies were selected that 1) identified patients with unipolar major depression, 2) made diagnoses of psychosis based on the presence of delusions or hallucinations, 3) characterized past or subsequent episodes as psychotic or nonpsychotic, and 4) were published in English...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792049/five-year-suicidal-ideation-trajectories-among-women-receiving-or-being-denied-an-abortion
#4
M Antonia Biggs, Heather Gould, Rana E Barar, Diana G Foster
OBJECTIVE: The aim of this study was to assess the effects of receiving compared with being denied an abortion on women's experiences of suicidal ideation over 5 years. METHOD: The authors recruited 956 women from 30 U.S. abortion facilities. Women were interviewed by telephone 1 week after their abortion visit, then every 6 months for 5 years. Women who received near-limit abortions were compared with women who were denied an abortion and carried their pregnancies to term (turnaway-birth group)...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29730938/continuation-of-atypical-antipsychotic-medication-during-early-pregnancy-and-the-risk-of-gestational-diabetes
#5
Yoonyoung Park, Sonia Hernandez-Diaz, Brian T Bateman, Jacqueline M Cohen, Rishi J Desai, Elisabetta Patorno, Robert J Glynn, Lee S Cohen, Helen Mogun, Krista F Huybrechts
OBJECTIVE: Some atypical antipsychotics are associated with metabolic side effects, which are risk factors for gestational diabetes. The authors examined the risk of developing gestational diabetes associated with the continuation of treatment with aripiprazole, ziprasidone, quetiapine, risperidone, and olanzapine during pregnancy compared with discontinuation of these antipsychotic drugs. METHOD: Nondiabetic pregnant women who were linked to a live-born infant and enrolled in Medicaid (2000-2010) and who received one or more prescriptions dispensed for an antipsychotic drug during the 3 months before pregnancy were included in the analyses...
May 7, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29730937/familiality-of-psychiatric-disorders-and-risk-of-postpartum-psychiatric-episodes-a-population-based-cohort-study
#6
Anna E Bauer, Merete L Maegbaek, Xiaoqin Liu, Naomi R Wray, Patrick F Sullivan, William C Miller, Samantha Meltzer-Brody, Trine Munk-Olsen
OBJECTIVE: Postpartum psychiatric disorders are common and morbid complications of pregnancy. The authors sought to evaluate how family history of psychiatric disorders is associated with postpartum psychiatric disorders in proband mothers with and without a prior psychiatric history by assessing degree of relationship, type of disorder, and sex of family members. METHOD: The authors linked Danish birth and psychiatric treatment registers to evaluate familial risk of postpartum psychiatric episodes in a national population-based cohort...
May 7, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690794/integrating-health-and-mental-health-services-a-past-and-future-history
#7
Benjamin G Druss, Howard H Goldman
The authors trace the modern history, current landscape, and future prospects for integration between mental health and general medical care in the United States. Research and new treatment models developed in the 1980s and early 1990s helped inform federal legislation, including the 2008 Mental Health Parity and Addiction Equity Act and the 2010 Affordable Care Act, which in turn are creating new opportunities to further integrate services. Future efforts should build on this foundation to develop clinical, service-level, and public health approaches that more fully integrate mental, medical, substance use, and social services...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690793/clinical-implementation-of-pharmacogenetic-decision-support-tools-for-antidepressant-drug-prescribing
#8
Zane Zeier, Linda L Carpenter, Ned H Kalin, Carolyn I Rodriguez, William M McDonald, Alik S Widge, Charles B Nemeroff
The accrual and analysis of genomic sequencing data have identified specific genetic variants that are associated with major depressive disorder. Moreover, substantial investigations have been devoted to identifying gene-drug interactions that affect the response to antidepressant medications by modulating their pharmacokinetic or pharmacodynamic properties. Despite these advances, individual responses to antidepressants, as well as the unpredictability of adverse side effects, leave clinicians with an imprecise prescribing strategy that often relies on trial and error...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690792/physical-activity-and-incident-depression-a-meta-analysis-of-prospective-cohort-studies
#9
Felipe B Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Phillip B Ward, Edson S Silva, Mats Hallgren, Antonio Ponce De Leon, Andrea L Dunn, Andrea C Deslandes, Marcelo P Fleck, Andre F Carvalho, Brendon Stubbs
OBJECTIVE: The authors examined the prospective relationship between physical activity and incident depression and explored potential moderators. METHOD: Prospective cohort studies evaluating incident depression were searched from database inception through Oct. 18, 2017, on PubMed, PsycINFO, Embase, and SPORTDiscus. Demographic and clinical data, data on physical activity and depression assessments, and odds ratios, relative risks, and hazard ratios with 95% confidence intervals were extracted...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690791/anxiety-about-antidepressants
#10
Roy H Perlis
No abstract text is available yet for this article.
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690790/neuroscience-of-addiction-relevance-to-prevention-and-treatment
#11
Nora D Volkow, Maureen Boyle
Addiction, the most severe form of substance use disorder, is a chronic brain disorder molded by strong biosocial factors that has devastating consequences to individuals and to society. Our understanding of substance use disorder has advanced significantly over the last 3 decades in part due to major progress in genetics and neuroscience research and to the development of new technologies, including tools to interrogate molecular changes in specific neuronal populations in animal models of substance use disorder, as well as brain imaging devices to assess brain function and neurochemistry in humans...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29656666/can-a-framework-be-established-for-the-safe-use-of-ketamine
#12
Robert Freedman, Alan S Brown, Tyrone D Cannon, Benjamin G Druss, Felton J Earls, Javier Escobar, Yasmin L Hurd, David A Lewis, Carlos López-Jaramillo, Joan Luby, Helen S Mayberg, Terrie E Moffitt, Maria Oquendo, Roy H Perlis, Daniel S Pine, A John Rush, Carol A Tamminga, Mauricio Tohen, Eduard Vieta, Katherine L Wisner, Yu Xin
No abstract text is available yet for this article.
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29656665/prevalence-and-correlates-of-prescription-stimulant-use-misuse-use-disorders-and-motivations-for-misuse-among-adults-in-the-united-states
#13
Wilson M Compton, Beth Han, Carlos Blanco, Kimberly Johnson, Christopher M Jones
OBJECTIVE: The authors sought to simultaneously examine the prevalence and correlates of prescription stimulant use, misuse, use disorders, and motivations for misuse in the U.S. adult population. METHOD: This was a nationally representative household population study of adults age 18 or older from the 2015 and 2016 National Surveys on Drug Use and Health (N=102,000). Measurements included prescription stimulant use, use without misuse, misuse without use disorders, and misuse with use disorders, as well as sociodemographic characteristics, health conditions, and mental health factors...
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29656664/epigenetic-aging-in-major-depressive-disorder
#14
Laura K M Han, Moji Aghajani, Shaunna L Clark, Robin F Chan, Mohammad W Hattab, Andrey A Shabalin, Min Zhao, Gaurav Kumar, Lin Ying Xie, Rick Jansen, Yuri Milaneschi, Brian Dean, Karolina A Aberg, Edwin J C G van den Oord, Brenda W J H Penninx
OBJECTIVE: Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue. METHOD: DNAm age was estimated using all methylation sites in blood of 811 depressed patients and 319 control subjects with no lifetime psychiatric disorders and low depressive symptoms from the Netherlands Study of Depression and Anxiety...
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29656663/efficacy-and-safety-of-intranasal-esketamine-for-the-rapid-reduction-of-symptoms-of-depression-and-suicidality-in-patients-at-imminent-risk-for-suicide-results-of-a-double-blind-randomized-placebo-controlled-study
#15
Carla M Canuso, Jaskaran B Singh, Maggie Fedgchin, Larry Alphs, Rosanne Lane, Pilar Lim, Christine Pinter, David Hough, Gerard Sanacora, Husseini Manji, Wayne C Drevets
OBJECTIVE: The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major depression, including suicidality, among individuals at imminent suicide risk. METHOD: In a double-blind, multicenter, proof-of-concept study, 68 participants were randomly assigned to receive esketamine (84 mg) or placebo twice weekly for 4 weeks, in addition to comprehensive standard-of-care treatment. The primary efficacy endpoint was change in score from baseline to 4 hours after initial dose on the Montgomery-Åsberg Depression Rating Scale (MADRS)...
April 16, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29621902/all-for-one-and-one-for-all-mental-disorders-in-one-dimension
#16
Avshalom Caspi, Terrie E Moffitt
In both child and adult psychiatry, empirical evidence has now accrued to suggest that a single dimension is able to measure a person's liability to mental disorder, comorbidity among disorders, persistence of disorders over time, and severity of symptoms. This single dimension of general psychopathology has been termed "p," because it conceptually parallels a dimension already familiar to behavioral scientists and clinicians: the "g" factor of general intelligence. As the g dimension reflects low to high mental ability, the p dimension represents low to high psychopathology severity, with thought disorder at the extreme...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29621901/the-clinical-effectiveness-and-cost-effectiveness-of-lamotrigine-in-borderline-personality-disorder-a-randomized-placebo-controlled-trial
#17
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity Leeson, Fenella Lemonsky, Georgia Lykomitrou, Alan A Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
OBJECTIVE: The authors examined whether lamotrigine is a clinically effective and cost-effective treatment for people with borderline personality disorder. METHOD: This was a multicenter, double-blind, placebo-controlled randomized trial. Between July 2013 and November 2016, the authors recruited 276 people age 18 or over who met diagnostic criteria for borderline personality disorder. Individuals with coexisting bipolar affective disorder or psychosis, those already taking a mood stabilizer, and women at risk of pregnancy were excluded...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29621900/20-year-nationwide-follow-up-study-on-discontinuation-of-antipsychotic-treatment-in-first-episode-schizophrenia
#18
Jari Tiihonen, Antti Tanskanen, Heidi Taipale
OBJECTIVE: It is generally believed that after the first episode of schizophrenia, the risk of relapse decreases with time in patients who are stabilized. Many treatment guidelines recommend that after stabilization, antipsychotic treatment should be continued for 1-5 years, and longer exposure should be avoided if possible. However, there is no published evidence to substantiate this view. The authors used nationwide databases to investigate this issue. METHOD: Prospectively gathered nationwide register data were used to study the risk of treatment failure (psychiatric rehospitalization or death) after discontinuation of antipsychotic treatment...
April 6, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29558817/developmental-trajectories-of-the-orbitofrontal-cortex-and-anhedonia-in-middle-childhood-and-risk-for-substance-use-in-adolescence-in-a-longitudinal-sample-of-depressed-and-healthy-preschoolers
#19
Joan L Luby, Arpana Agrawal, Andy Belden, Diana Whalen, Rebecca Tillman, Deanna M Barch
OBJECTIVE: Deficits in reward processing are established in mood and substance use disorders and are known risk factors for these disorders. Volume reductions of the orbitofrontal cortex and the striatum, regions that subserve neural response to reward, have been shown to be related to anhedonia in depressive and substance use disorders. The authors sought to investigate how structural maturation of these regions in childhood varies with level of anhedonia and predicts later substance use...
March 21, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29558816/prenatal-primary-prevention-of-mental-illness-by-micronutrient-supplements-in-pregnancy
#20
Robert Freedman, Sharon K Hunter, M Camille Hoffman
Genes, infection, malnutrition, and other factors affecting fetal brain development are a major component of risk for a child's emotional development and later mental illnesses, including schizophrenia, bipolar disorder, and autism. Prenatal interventions to ameliorate that risk have yet to be established for clinical use. A systematic review of prenatal nutrients and childhood emotional development and later mental illness was performed. Randomized trials of folic acid, phosphatidylcholine, and omega-3 fatty acid supplements assess effects of doses beyond those adequate to remedy deficiencies to promote normal fetal development despite genetic and environmental risks...
March 21, 2018: American Journal of Psychiatry
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