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American Journal of Psychiatry

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https://www.readbyqxmd.com/read/29084454/altered-brain-developmental-trajectories-in-adolescents-after-initiating-drinking
#1
Adolf Pfefferbaum, Dongjin Kwon, Ty Brumback, Wesley K Thompson, Kevin Cummins, Susan F Tapert, Sandra A Brown, Ian M Colrain, Fiona C Baker, Devin Prouty, Michael D De Bellis, Duncan B Clark, Bonnie J Nagel, Weiwei Chu, Sang Hyun Park, Kilian M Pohl, Edith V Sullivan
OBJECTIVE: The authors sought evidence for altered adolescent brain growth trajectory associated with moderate and heavy alcohol use in a large national, multisite, prospective study of adolescents before and after initiation of appreciable alcohol use. METHOD: This study examined 483 adolescents (ages 12-21) before initiation of drinking and 1 and 2 years later. At the 2-year assessment, 356 participants continued to meet the study's no/low alcohol consumption entry criteria, 65 had initiated moderate drinking, and 62 had initiated heavy drinking...
October 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29084453/effect-of-early-life-fluoxetine-on-anxiety-like-behaviors-in-bdnf-val66met-mice
#2
Iva Dincheva, Jianmin Yang, Anfei Li, Tina Marinic, Helena Freilingsdorf, Chienchun Huang, B J Casey, Barbara Hempstead, Charles E Glatt, Francis S Lee, Kevin G Bath, Deqiang Jing
OBJECTIVE: Adolescence is a developmental stage in which the incidence of psychiatric disorders, such as anxiety disorders, peaks. Selective serotonin reuptake inhibitors (SSRIs) are the main class of agents used to treat anxiety disorders. However, the impact of SSRIs on the developing brain during adolescence remains unknown. The authors assessed the impact of developmentally timed SSRI administration in a genetic mouse model displaying elevated anxiety-like behaviors. METHOD: Knock-in mice containing a common human single-nucleotide polymorphism (Val66Met; rs6265) in brain-derived neurotrophic factor (BDNF), a growth factor implicated in the mechanism of action of SSRIs, were studied based on their established phenotype of increased anxiety-like behavior...
October 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29050505/late-onset-adhd-reconsidered-with-comprehensive-repeated-assessments-between-ages-10-and-25
#3
Margaret H Sibley, Luis A Rohde, James M Swanson, Lily T Hechtman, Brooke S G Molina, John T Mitchell, L Eugene Arnold, Arthur Caye, Traci M Kennedy, Arunima Roy, Annamarie Stehli
OBJECTIVE: Adolescents and young adults without childhood attention deficit hyperactivity disorder (ADHD) often present to clinics seeking stimulant medication for late-onset ADHD symptoms. Recent birth-cohort studies support the notion of late-onset ADHD, but these investigations are limited by relying on screening instruments to assess ADHD, not considering alternative causes of symptoms, or failing to obtain complete psychiatric histories. The authors address these limitations by examining psychiatric assessments administered longitudinally to the local normative comparison group of the Multimodal Treatment Study of ADHD...
October 20, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29050504/transgender-research-in-the-21st-century-a-selective-critical-review-from-a-neurocognitive-perspective
#4
Sven C Mueller, Griet De Cuypere, Guy T'Sjoen
Gender dysphoria describes the psychological distress caused by identifying with the sex opposite to the one assigned at birth. In recent years, much progress has been made in characterizing the needs of transgender persons wishing to transition to their preferred gender, thus helping to optimize care. This critical review of the literature examines their common mental health issues, several individual risk factors for psychiatric comorbidity, and current research on the underlying neurobiology. Prevalence rates of persons identifying as transgender and seeking help with transition have been rising steeply since 2000 across Western countries; the current U...
October 20, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969442/psychiatric-genomics-an-update-and-an-agenda
#5
Patrick F Sullivan, Arpana Agrawal, Cynthia M Bulik, Ole A Andreassen, Anders D Børglum, Gerome Breen, Sven Cichon, Howard J Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan W Smoller, Michael C O'Donovan
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver "actionable" findings-genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969441/the-effect-of-a-single-dose-of-intravenous-ketamine-on-suicidal-ideation-a-systematic-review-and-individual-participant-data-meta-analysis
#6
Samuel T Wilkinson, Elizabeth D Ballard, Michael H Bloch, Sanjay J Mathew, James W Murrough, Adriana Feder, Peter Sos, Gang Wang, Carlos A Zarate, Gerard Sanacora
OBJECTIVE: Suicide is a public health crisis with limited treatment options. The authors conducted a systematic review and individual participant data meta-analysis examining the effects of a single dose of ketamine on suicidal ideation. METHOD: Individual participant data were obtained from 10 of 11 identified comparison intervention studies that used either saline or midazolam as a control treatment. The analysis included only participants who had suicidal ideation at baseline (N=167)...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969440/exercise-and-the-prevention-of-depression-results-of-the-hunt-cohort-study
#7
Samuel B Harvey, Simon Øverland, Stephani L Hatch, Simon Wessely, Arnstein Mykletun, Matthew Hotopf
OBJECTIVE: The purpose of the present study was to address 1) whether exercise provides protection against new-onset depression and anxiety and 2) if so, the intensity and amount of exercise required to gain protection and, lastly, 3) the mechanisms that underlie any association. METHOD: A "healthy" cohort of 33,908 adults, selected on the basis of having no symptoms of common mental disorder or limiting physical health conditions, was prospectively followed for 11 years...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969439/improving-the-efficiency-of-psychotherapy-for-depression-computer-assisted-versus-standard-cbt
#8
Michael E Thase, Jesse H Wright, Tracy D Eells, Marna S Barrett, Stephen R Wisniewski, G K Balasubramani, Paul McCrone, Gregory K Brown
OBJECTIVE: The authors evaluated the efficacy and durability of a therapist-supported method for computer-assisted cognitive-behavioral therapy (CCBT) in comparison to standard cognitive-behavioral therapy (CBT). METHOD: A total of 154 medication-free patients with major depressive disorder seeking treatment at two university clinics were randomly assigned to either 16 weeks of standard CBT (up to 20 sessions of 50 minutes each) or CCBT using the "Good Days Ahead" program...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969438/adjunctive-bright-light-therapy-for-bipolar-depression-a-randomized-double-blind-placebo-controlled-trial
#9
Dorothy K Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John Jesse Dills, James Luther, Amy Yang, Jody D Ciolino, Howard Seltman, Stephen R Wisniewski, Michael Terman, Katherine L Wisner
OBJECTIVE: Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and limited treatment options. Building on promising pilot data, the authors conducted a 6-week randomized double-blind placebo-controlled trial to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression. The aims were to determine remission rate, depression symptom level, and rate of mood polarity switch, as well as to explore sleep quality. METHOD: The study enrolled depressed adults with bipolar I or II disorder who were receiving stable dosages of antimanic medication (excluding patients with hypomania or mania, mixed symptoms, or rapid cycling)...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28946763/dissociation-in-psychiatric-disorders-a-meta-analysis-of-studies-using-the-dissociative-experiences-scale
#10
Lisa Lyssenko, Christian Schmahl, Laura Bockhacker, Ruben Vonderlin, Martin Bohus, Nikolaus Kleindienst
OBJECTIVE: Dissociation is a complex, ubiquitous construct in psychopathology. Symptoms of dissociation are present in a variety of mental disorders and have been connected to higher burden of illness and poorer treatment response, and not only in disorders with high levels of dissociation. This meta-analysis offers a systematic and evidence-based study of the prevalence and distribution of dissociation, as assessed by the Dissociative Experiences Scale, within different categories of mental disorders, and it updates an earlier meta-analysis...
September 26, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28946762/cannabis-use-and-risk-of-prescription-opioid-use-disorder-in-the-united-states
#11
Mark Olfson, Melanie M Wall, Shang-Min Liu, Carlos Blanco
OBJECTIVE: The authors sought to determine whether cannabis use is associated with a change in the risk of incident nonmedical prescription opioid use and opioid use disorder at 3-year follow-up. METHOD: The authors used logistic regression models to assess prospective associations between cannabis use at wave 1 (2001-2002) and nonmedical prescription opioid use and prescription opioid use disorder at wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions...
September 26, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28946761/randomized-double-blind-placebo-controlled-trial-of-asenapine-maintenance-therapy-in-adults-with-an-acute-manic-or-mixed-episode-associated-with-bipolar-i-disorder
#12
Armin Szegedi, Suresh Durgam, Mary Mackle, Sung Yun Yu, Xiao Wu, Maju Mathews, Ronald P Landbloom
OBJECTIVE: The authors determined the efficacy and safety of asenapine in preventing recurrence of any mood episode in adults with bipolar I disorder. METHOD: Adults with an acute manic or mixed episode per DSM-IV-TR criteria were enrolled in this randomized, placebo-controlled trial consisting of an initial 12- to 16-week open-label period and a 26-week double-blind randomized withdrawal period. The target asenapine dosage was 10 mg b.i.d. in the open-label period but could be titrated down to 5 mg b...
September 26, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28945120/methylphenidate-for-apathy-in-community-dwelling-older-veterans-with-mild-alzheimer-s-disease-a-double-blind-randomized-placebo-controlled-trial
#13
Prasad R Padala, Kalpana P Padala, Shelly Y Lensing, Daniel Ramirez, Varun Monga, Melinda M Bopp, Paula K Roberson, Richard A Dennis, Frederick Petty, Dennis H Sullivan, William J Burke
OBJECTIVE: Apathy is a common behavioral problem in Alzheimer's disease. Apathy has profound consequences, such as functional impairment, higher service utilization, higher caregiver burden, and increased mortality. The authors' objective was to study the effects of methylphenidate on apathy in Alzheimer's disease. METHOD: A 12-week, prospective, double-blind, randomized, placebo-controlled trial (methylphenidate versus placebo) was conducted in community-dwelling veterans (N=60) with mild Alzheimer's disease...
September 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28945118/psychopharmacological-treatment-in-the-raise-etp-study-outcomes-of-a-manual-and-computer-decision-support-system-based-intervention
#14
Delbert G Robinson, Nina R Schooler, Christoph U Correll, Majnu John, Benji T Kurian, Patricia Marcy, Alexander L Miller, Ronny Pipes, Madhukar H Trivedi, John M Kane
OBJECTIVE: The Recovery After an Initial Schizophrenia Episode-Early Treatment Program compared NAVIGATE, a comprehensive program for first-episode psychosis, to clinician-choice community care over 2 years. Quality of life and psychotic and depressive symptom outcomes were found to be better with NAVIGATE. Compared with previous comprehensive first-episode psychosis interventions, NAVIGATE medication treatment included unique elements of detailed first-episode-specific psychotropic medication guidelines and a computerized decision support system to facilitate shared decision making regarding prescriptions...
September 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28838251/increased-risk-of-smoking-in-female-adolescents-who-had-childhood-adhd
#15
Irene J Elkins, Gretchen R B Saunders, Stephen M Malone, Margaret A Keyes, Diana R Samek, Matt McGue, William G Iacono
OBJECTIVE: This study examined the effects of childhood attention deficit hyperactivity disorder (ADHD) symptoms, both inattention and hyperactivity-impulsivity, on the development of smoking in male and female adolescents. METHOD: Twin difference methods were used to control for shared genetic and environmental confounders in three population-based, same-sex twin samples (N=3,762; 64% monozygotic). One cohort oversampled female adolescents with ADHD beginning in childhood...
August 25, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29088941/correction
#16
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29088940/treatment-of-bipolar-disorder-in-the-elderly
#17
David L Dunner
No abstract text is available yet for this article.
November 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29088939/different-standards-when-assessing-the-evidence-for-psychodynamic-therapy-response-to-cristea-et-al
#18
Christiane Steinert, Thomas Munder, Sven Rabung, Jürgen Hoyer, Falk Leichsenring
No abstract text is available yet for this article.
November 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29088938/integrating-behavioral-health-and-primary-careedited-by-robert-e-feinstein-joseph-v-connelly-and-marilyn-s-feinstein-new-york-oxford-university-press-2017-592-pp-89-95-hardcover
#19
Rachel B Katz, Benjamin M Cherry
No abstract text is available yet for this article.
November 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29088937/telepsychiatry-and-health-technologies-a-guide-for-mental-health-professionalsedited-by-peter-yellowlees-m-b-b-s-m-d-and-jay-h-shore-m-d-m-p-h-washington-d-c-american-psychiatric-association-publishing-2018-400-pp-69-00-paperback
#20
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