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American Journal of Psychiatry

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https://www.readbyqxmd.com/read/30021460/meta-analysis-of-89-structural-mri-studies-in-posttraumatic-stress-disorder-and-comparison-with-major-depressive-disorder
#1
Konstantinos Bromis, Maria Calem, Antje A T S Reinders, Steven C R Williams, Matthew J Kempton
OBJECTIVE: The authors conducted a comprehensive meta-analysis of MRI region-of-interest and voxel-based morphometry (VBM) studies in posttraumatic stress disorder (PTSD). Because patients have high rates of comorbid depression, an additional objective was to compare the findings to a meta-analysis of MRI studies in depression. METHOD: The MEDLINE database was searched for studies from 1985 through 2016. A total of 113 studies met inclusion criteria and were included in an online database...
July 19, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/30021459/synaptic-proteome-compensation-and-resilience-to-psychosis-in-alzheimer-s-disease
#2
Josh M Krivinko, Susan L Erickson, Ying Ding, Zhe Sun, Peter Penzes, Matthew L MacDonald, Nathan A Yates, Milos D Ikonomovic, Oscar L Lopez, Robert A Sweet, Julia Kofler
OBJECTIVE: The presence of psychosis in Alzheimer's disease denotes a phenotype with more rapid cognitive deterioration than in Alzheimer's disease without psychosis. Discovery of novel pharmacotherapies that engage therapeutic targets for prevention or treatment of Alzheimer's disease with psychosis would benefit from identifying the neurobiology of resilience to psychosis in Alzheimer's disease. The primary objective of this study was to determine whether alterations in the synaptic proteome were associated with resilience to psychotic symptoms in Alzheimer's disease and, if present, were independent of neuropathologic burden...
July 19, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/30021458/the-genetic-epidemiology-of-treated-major-depression-in-sweden
#3
Kenneth S Kendler, Henrik Ohlsson, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist
OBJECTIVE: The authors examined the heritability of treated major depression in a twin and full/half-sibling design, to describe key genetic epidemiological features of major depression and to determine which clinical indices of genetic liability optimally predict risk of depression in relatives. METHOD: The authors examined all treated cases of major depression in Sweden recorded in inpatient, specialist, and primary care registries and, using OpenMx, estimated the etiologic role of genetic and environmental factors from monozygotic and dizygotic twin pairs and full and half siblings reared together and apart (total N=1,718,863 pairs)...
July 19, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/30021457/as-safe-as-possible-asap-a-brief-app-supported-inpatient-intervention-to-prevent-postdischarge-suicidal-behavior-in-hospitalized-suicidal-adolescents
#4
Betsy D Kennard, Tina Goldstein, Aleksandra A Foxwell, Dana L McMakin, Kristin Wolfe, Candice Biernesser, Alexandra Moorehead, Antoine Douaihy, Lucas Zullo, Erin Wentroble, Victoria Owen, Jamie Zelazny, Satish Iyengar, Giovanna Porta, David Brent
OBJECTIVE: The authors report on a pilot study of an inpatient intervention for suicidal adolescents, As Safe as Possible (ASAP), supported by a smartphone app (BRITE) to reduce suicide attempts following hospital discharge. METHOD: Across two sites, 66 adolescents hospitalized for suicidal ideation (N=26) or a recent suicide attempt (N=40) were randomly assigned to the ASAP intervention program plus treatment as usual or to treatment as usual alone. ASAP, which focuses on emotion regulation and safety planning, is a 3-hour intervention delivered on the inpatient unit...
July 19, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29921146/reward-processing-in-depression-a-conceptual-and-meta-analytic-review-across-fmri-and-eeg-studies
#5
Hanna Keren, Georgia O'Callaghan, Pablo Vidal-Ribas, George A Buzzell, Melissa A Brotman, Ellen Leibenluft, Pedro M Pan, Liana Meffert, Ariela Kaiser, Selina Wolke, Daniel S Pine, Argyris Stringaris
OBJECTIVE: A role for aberrant reward processing in the pathogenesis of depression has long been proposed. However, no review has yet examined its role in depression by integrating conceptual and quantitative findings across functional MRI (fMRI) and EEG methodologies. The authors quantified these effects, with an emphasis on development. METHOD: A total of 38 fMRI and 12 EEG studies were entered into fMRI and EEG meta-analyses. fMRI studies primarily examined reward anticipation and reward feedback...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29921145/the-burden-of-bereavement-early-onset-depression-and-impairment-in-youths-bereaved-by-sudden-parental-death-in-a-7-year-prospective-study
#6
Steven Pham, Giovanna Porta, Candice Biernesser, Monica Walker Payne, Satish Iyengar, Nadine Melhem, David A Brent
OBJECTIVE: The authors sought to determine the long-term impact of sudden parental death on youths and pathways between youth bereavement and impairment. METHODS: Youths (N=216) who lost a parent to suicide, accident, or sudden natural death and nonbereaved youths (N=172) were followed periodically for up to 7 years. The incidence and prevalence of disorder and of functional impairment, as well as pathways to impairment, were assessed using Cox and mixed-effects logistic regression and structural equation modeling...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29921144/a-randomized-controlled-trial-of-parent-child-psychotherapy-targeting-emotion-development-for-early-childhood-depression
#7
Joan L Luby, Deanna M Barch, Diana Whalen, Rebecca Tillman, Kenneth E Freedland
OBJECTIVE: Clinical depression in children as young as age 3 has been validated, and prevalence rates are similar to the school-age disorder. Homotypic continuity between early and later childhood depression has been observed, with alterations in brain function and structure similar to those reported in depressed adults. These findings highlight the importance of identifying and treating depression as early as developmentally possible, given the relative treatment resistance and small effect sizes for treatments later in life...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29921143/individual-treatment-of-posttraumatic-stress-disorder-using-mantram-repetition-a-randomized-clinical-trial
#8
Jill E Bormann, Steven R Thorp, Eric Smith, Mark Glickman, Danielle Beck, Dorothy Plumb, Shibei Zhao, Princess E Ackland, Carie S Rodgers, Pia Heppner, Lawrence R Herz, A Rani Elwy
OBJECTIVE: Previous studies suggest that group "mantram" (sacred word) repetition therapy, a non-trauma-focused complementary therapy for posttraumatic stress disorder (PTSD), may be an effective treatment for veterans. The authors compared individually delivered mantram repetition therapy and another non-trauma-focused treatment for PTSD. METHOD: The study was a two-site, open-allocation, blinded-assessment randomized trial involving 173 veterans diagnosed with military-related PTSD from two Veterans Affairs outpatient clinics (January 2012 to March 2014)...
June 20, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792052/randomized-clinical-trial-of-computerized-and-clinician-delivered-cbt-in-comparison-with-standard-outpatient-treatment-for-substance-use-disorders-primary-within-treatment-and-follow-up-outcomes
#9
Brian D Kiluk, Charla Nich, Matthew B Buck, Kathleen A Devore, Tami L Frankforter, Donna M LaPaglia, Srinivas B Muvvala, Kathleen M Carroll
OBJECTIVE: Previous trials have demonstrated the efficacy and durability of computer-based cognitive-behavioral therapy (CBT4CBT) as an add-on to standard outpatient care in a range of treatment-seeking populations. In this study, the authors evaluated the efficacy and safety of CBT4CBT as a virtual stand-alone treatment, delivered with minimal clinical monitoring, and clinician-delivered cognitive-behavioral therapy (CBT) compared with treatment as usual in a heterogeneous sample of treatment-seeking outpatients with substance use disorders...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792051/predicting-suicide-attempts-and-suicide-deaths-following-outpatient-visits-using-electronic-health-records
#10
Gregory E Simon, Eric Johnson, Jean M Lawrence, Rebecca C Rossom, Brian Ahmedani, Frances L Lynch, Arne Beck, Beth Waitzfelder, Rebecca Ziebell, Robert B Penfold, Susan M Shortreed
OBJECTIVE: The authors sought to develop and validate models using electronic health records to predict suicide attempt and suicide death following an outpatient visit. METHOD: Across seven health systems, 2,960,929 patients age 13 or older (mean age, 46 years; 62% female) made 10,275,853 specialty mental health visits and 9,685,206 primary care visits with mental health diagnoses between Jan. 1, 2009, and June 30, 2015. Health system records and state death certificate data identified suicide attempts (N=24,133) and suicide deaths (N=1,240) over 90 days following each visit...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792050/risk-of-psychosis-in-recurrent-episodes-of-psychotic-and-nonpsychotic-major-depressive-disorder-a-systematic-review-and-meta-analysis
#11
J Craig Nelson, David Bickford, Kevin Delucchi, Jess G Fiedorowicz, William H Coryell
OBJECTIVE: The authors conducted a systematic review and meta-analysis to determine whether the risk of psychosis is higher in past or future episodes in patients with major depression with psychotic features than in patients with nonpsychotic depression. METHOD: PubMed, Embase, and PsycINFO were searched, and studies were selected that 1) identified patients with unipolar major depression, 2) made diagnoses of psychosis based on the presence of delusions or hallucinations, 3) characterized past or subsequent episodes as psychotic or nonpsychotic, and 4) were published in English...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29792049/five-year-suicidal-ideation-trajectories-among-women-receiving-or-being-denied-an-abortion
#12
M Antonia Biggs, Heather Gould, Rana E Barar, Diana G Foster
OBJECTIVE: The aim of this study was to assess the effects of receiving compared with being denied an abortion on women's experiences of suicidal ideation over 5 years. METHOD: The authors recruited 956 women from 30 U.S. abortion facilities. Women were interviewed by telephone 1 week after their abortion visit, then every 6 months for 5 years. Women who received near-limit abortions were compared with women who were denied an abortion and carried their pregnancies to term (turnaway-birth group)...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29730937/familiality-of-psychiatric-disorders-and-risk-of-postpartum-psychiatric-episodes-a-population-based-cohort-study
#13
Anna E Bauer, Merete L Maegbaek, Xiaoqin Liu, Naomi R Wray, Patrick F Sullivan, William C Miller, Samantha Meltzer-Brody, Trine Munk-Olsen
OBJECTIVE: Postpartum psychiatric disorders are common and morbid complications of pregnancy. The authors sought to evaluate how family history of psychiatric disorders is associated with postpartum psychiatric disorders in proband mothers with and without a prior psychiatric history by assessing degree of relationship, type of disorder, and sex of family members. METHOD: The authors linked Danish birth and psychiatric treatment registers to evaluate familial risk of postpartum psychiatric episodes in a national population-based cohort...
May 7, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690794/integrating-health-and-mental-health-services-a-past-and-future-history
#14
Benjamin G Druss, Howard H Goldman
The authors trace the modern history, current landscape, and future prospects for integration between mental health and general medical care in the United States. Research and new treatment models developed in the 1980s and early 1990s helped inform federal legislation, including the 2008 Mental Health Parity and Addiction Equity Act and the 2010 Affordable Care Act, which in turn are creating new opportunities to further integrate services. Future efforts should build on this foundation to develop clinical, service-level, and public health approaches that more fully integrate mental, medical, substance use, and social services...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690793/clinical-implementation-of-pharmacogenetic-decision-support-tools-for-antidepressant-drug-prescribing
#15
Zane Zeier, Linda L Carpenter, Ned H Kalin, Carolyn I Rodriguez, William M McDonald, Alik S Widge, Charles B Nemeroff
The accrual and analysis of genomic sequencing data have identified specific genetic variants that are associated with major depressive disorder. Moreover, substantial investigations have been devoted to identifying gene-drug interactions that affect the response to antidepressant medications by modulating their pharmacokinetic or pharmacodynamic properties. Despite these advances, individual responses to antidepressants, as well as the unpredictability of adverse side effects, leave clinicians with an imprecise prescribing strategy that often relies on trial and error...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29690790/neuroscience-of-addiction-relevance-to-prevention-and-treatment
#16
Nora D Volkow, Maureen Boyle
Addiction, the most severe form of substance use disorder, is a chronic brain disorder molded by strong biosocial factors that has devastating consequences to individuals and to society. Our understanding of substance use disorder has advanced significantly over the last 3 decades in part due to major progress in genetics and neuroscience research and to the development of new technologies, including tools to interrogate molecular changes in specific neuronal populations in animal models of substance use disorder, as well as brain imaging devices to assess brain function and neurochemistry in humans...
April 25, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29961368/can-personality-disorders-be-redefined-in-personality-trait-terms
#17
Andrew E Skodol
No abstract text is available yet for this article.
July 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29961367/antidepressant-resistant-depression-in-patients-with-comorbid-subclinical-hypothyroidism-or-high-normal-tsh-levels
#18
Bruce M Cohen, Barbara R Sommer, Alexander Vuckovic
No abstract text is available yet for this article.
July 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29961366/abnormal-sensitization-of-neural-and-behavioral-responses-to-socially-relevant-images-in-individuals-with-borderline-personality-disorder-implications-for-guiding-more-effective-targeting-of-treatments
#19
https://www.readbyqxmd.com/read/29961365/medication-assisted-treatment-for-alcohol-use-disorder-hope-for-incarcerated-patients-and-for-our-communities
#20
Alexandra Aaronson, Jonathan Adelstein, John G Csernansky
No abstract text is available yet for this article.
July 1, 2018: American Journal of Psychiatry
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