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BJOG: An International Journal of Obstetrics and Gynaecology

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https://www.readbyqxmd.com/read/28322491/threats-to-reliability-risk-erroneous-conclusions-a-survey-of-prospective-registration-and-sample-sizes-of-randomised-trials-in-women-s-health
#1
S K Nijjar, K S Khan
OBJECTIVE: Prospective registration of clinical trials has been required since 2005. We aimed to assess concordance between registered and reported sample sizes among prospectively registered randomised controlled trials (RCTs) in obstetrics and gynaecology. DESIGN: Analysis of prospectively registered and published data. SETTING: Women's health. SAMPLE: Obstetrics and gynaecology RCTs published in eight journals in 2015...
March 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28319317/p-hacking-can-be-avoided-with-core-outcome-sets
#2
J van 't Hooft, K S Khan
The article by Thornton et al. establishes with data from progestogen trials something we have always feared, i.e. the corruption of reported results through selective publication of outcomes. In their analysis, trials with a predefined primary outcome showed no effect of progesterone consistently; trials that did not report a predefined primary outcome, however, had a tendency to show more promising results. Indeed this problem is so ingrained that even prospective registration of trials has not fully addressed it...
March 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28319314/progesterone-to-prevent-preterm-birth-the-studies-are-getting-better-but-there-is-still-room-for-improvement
#3
Carr Men Chung, Maud van Zijl, Jeffrey A Keelan, Ben Willem Mol
Spontaneous preterm birth (PTB) remains one of the pressing problems of modern obstetrics. Allen and Corner first isolated progesterone and proposed the name because of its pro-gestational activity (Allen 1930). Progesterone prolongs pregnancy via a range of actions in the myometrium, cervix and placenta which, when exploited pharmacologically, might delay or even prevent PTB. This article is protected by copyright. All rights reserved.
March 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28318099/inadvertent-p-hacking-among-trials-and-systematic-reviews-of-the-effect-of-progestogens-in-pregnancy-a-systematic-review-and-meta-analysis
#4
REVIEW
M Prior, R Hibberd, N Asemota, J G Thornton
BACKGROUND: Progestogens have been evaluated in numerous trials and meta-analyses, many of which concluded they were effective. However, two large trials PROMISE and OPPTIMUM have recently concluded that progesterone was ineffective. This raises the possibility that earlier studies and reviews had been biased by either selective publication or selective choice of outcomes, so called "P-hacking". OBJECTIVES: To compare the findings all progestogen trials and systematic reviews with those of trials with pre-registered primary outcomes which avoided selective outcome reporting...
March 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28317327/a-research-agenda-for-moving-early-medical-pregnancy-termination-over-the-counter
#5
REVIEW
Nathalie Kapp, Daniel Grossman, Emily Jackson, Laura Castleman, Dalia Brahmi
Given the overall safety profile and increasing availability of medical pregnancy termination drugs, we asked: would the mifepristone-misoprostol regimen for medical termination at ≤10 weeks gestation meet U.S. FDA regulatory criteria for over-the-counter (OTC) approval, and if not, what are the present research gaps? We conducted a literature review of consumer behaviors necessary for a successful OTC application for medical termination ≤10 weeks and identified crucial research gaps. If we were to embark on a development program for OTC or more generally, self-use of medical termination, the critical elements missing are the label comprehension, self -selection and actual use studies...
March 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28317228/does-antenatal-care-timing-influence-stillbirth-risk-in-the-third-trimester-a-secondary-analysis-of-perinatal-death-audit-data-in-south-africa
#6
Tina Lavin, Robert Pattinson
OBJECTIVE: To explore stillbirth risk across gestation in three provinces of South Africa with different antenatal care schedules. DESIGN: Retrospective audit of perinatal death data using South Africa's Perinatal Problem Identification Program. SETTING: In 2008, the Basic Antenatal Care Programme was introduced in Limpopo and Mpumalanga provinces, reducing appointments to five visits at booking, 20,26,32,38 weeks and 41 weeks if required...
March 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28301716/prenatal-screening-it-is-not-just-about-down-syndrome
#7
Mary E Norton
Currently available prenatal genetic testing options include a bewildering array of tests from which patients, providers, insurers, and various health systems have to select. In many cases, patients or providers undergo or recommend multiple screening tests focused on the same conditions, for fear of missing something, even if the chance of that is very small. In the commentary in this issue of BJOG by Alfirevic and colleagues (Alfirevic Z, et al. BJOG In Press), the authors opine on the relationship between cell free DNA screening (cfDNA) and first trimester anatomy ultrasound...
March 16, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28299904/management-of-breech-presentation-green-top-guideline-no-20b
#8
(no author information available yet)
No abstract text is available yet for this article.
March 16, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28299867/external-cephalic-version-and-reducing-the-incidence-of-term-breech-presentation-green-top-guideline-no-20a
#9
(no author information available yet)
No abstract text is available yet for this article.
March 16, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294509/validation-of-an-emergency-triage-scale-for-obstetrics-and-gynaecology-a-prospective-study
#10
N Veit-Rubin, P Brossard, A Gayet-Ageron, C-Y Montandon, J Simon, O Irion, O T Rutschmann, B Martinez de Tejada
OBJECTIVE: To evaluate the reliability of a four-level triage scale for obstetrics and gynaecology emergencies and to explore the factors associated with an optimal triage. DESIGN: Thirty clinical vignettes presenting the most frequent indications for obstetrics and gynaecology emergency consultations were evaluated twice using a computerised simulator. SETTING: The study was performed at the emergency unit of obstetrics and gynaecology at the Geneva University Hospitals...
March 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294497/tubal-origin-of-ovarian-high-grade-serous-carcinoma-time-to-let-go-of-the-wrong-end-of-the-stick
#11
N Singh, C B Gilks
No abstract text is available yet for this article.
March 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294496/timing-of-antenatal-corticosteroid-administration-and-survival-in-extremely-preterm-infants-a-national-population-based-cohort-study
#12
H Norberg, J Kowalski, K Maršál, M Norman
OBJECTIVE: To explore the association between administration-to-birth interval of antenatal corticosteroids (ACS) and survival in extremely preterm infants. DESIGN: Population-based prospective cohort study. SETTING: All obstetric and neonatal units in Sweden from 1 April 2004 to 31 March 2007. POPULATION: All live-born infants (n = 707) born at 22-26 completed weeks of gestation. METHODS: The relationship between time from first administration of ACS to delivery and survival was investigated using Cox proportional hazards regression analysis...
March 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28296146/epidemiology-of-uterine-fibroids-a-systematic-review
#13
REVIEW
Elizabeth A Stewart, Charlotte Cookson, Ruth A Gandolfo, Renate Schulze-Rath
BACKGROUND: Uterine fibroids (UFs) are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility. OBJECTIVES: To examine UF epidemiology and to evaluate the relative strengths of putative risk factors. SEARCH STRATEGY: MEDLINE and Embase were searched for studies published in English between January 1995 and April 2015. SELECTION CRITERIA: Publications reporting relevant data from registries and other observational studies with over 1000 patients and single-centre studies with over 100 patients were selected...
March 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294506/changes-in-management-policies-for-extremely-preterm-births-and-neonatal-outcomes-from-2003-to-2012-two-population-based-studies-in-10-european-regions
#14
M Bonet, M Cuttini, A Piedvache, E M Boyle, P H Jarreau, L Kollée, R F Maier, D W A Milligan, P Van Reempts, T Weber, H Barros, J Gadzinowki, E S Draper, J Zeitlin
OBJECTIVE: to investigate changes in maternity and neonatal unit policies towards extremely preterm infants (EPTI) between 2003 and 2012 and concurrent trends in their mortality and morbidity in ten European regions. DESIGN: population-based cohort studies in 2003 (MOSAIC study) and 2011/12 (EPICE study) and questionnaires from hospitals. SETTING: 70 hospitals in ten European regions. POPULATION: infants born at <27 weeks of gestational age (GA) in hospitals participating in both the MOSAIC and EPICE studies (1240 in 2003, 1293 in 2011/2012)...
March 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28296016/subcutaneous-closure-after-cesarean-delivery-evidence-update
#15
Gustavo Vilchez, Eftichia V Kontopoulos
According to the National Center for Health Statistics of the Center for Disease Control, there were 1.284.551 cesarean deliveries in the US in 2014. As such, it is the most common abdominal surgery performed in the United States, with incidence of wound complications at 5%. Among variables affecting wound complication rates is the suturing the subcutaneous tissue. This article is protected by copyright. All rights reserved.
March 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28295991/antenatal-corticosteroids-it-s-all-about-timing
#16
Cynthia Gyamfi-Bannerman
Antenatal corticosteroids have been shown consistently to improve respiratory and other outcomes for infants born preterm (Roberts D et al. Cochrane database of systematic reviews. 2006(3):CD004454). Since Liggins and Howie we know that timing of corticosteroid administration influences the likelihood of benefit (Liggins GC et al. Pediatrics. 1972;50(4):515-525; Ring AM et al. Am J Obstet Gynecol. 2007;196(5):457 e451-456). In fact, the lack of benefit after seven days in their trial led to numerous studies evaluating serial administration of steroids...
March 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294527/peripartum-type-b-aortic-dissection-in-patients-with-marfan-syndrome-who-underwent-aortic-root-replacement-a-case-series-study
#17
Seisuke Sayama, Norifumi Takeda, Takayuki Iriyama, Ryo Inuzuka, Sonoko Maemura, Daishi Fujita, Haruo Yamauchi, Kan Nawata, Masahiko Bougaki, Hironobu Hyodo, Rieko Shitara, Toshio Nakayama, Atsushi Komatsu, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
OBJECTIVE: To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic aortic root replacement (ARR). DESIGN: Retrospective case series study. SETTING: Tertiary perinatal care center at a university hospital. POPULATION: Pregnant women fulfilling the revised Ghent nosology (2010) criteria for MFS that were managed at our institute...
March 11, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28294519/the-management-of-the-cardiac-patient-in-labour-primum-non-nocere
#18
Rohan D'Souza, Mathew Sermer, Candice Silversides
Cauldwell et al. discuss three aspects in the management of labour in pregnant women with cardiac disease, for which evidence is limited and most recommendations based on clinical experience. A few points require consideration as expert opinions differ. This article is protected by copyright. All rights reserved.
March 10, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28278351/the-association-of-protein-intake-amount-and-type-with-ovarian-antral-follicle-counts-among-infertile-women-results-from-the-earth-prospective-study-cohort
#19
Irene Souter, Yu-Han Chiu, Maria Batsis, Myriam C Afeiche, Paige L Williams, Russ Hauser, Jorge E Chavarro
OBJECTIVE: To evaluate the association between protein intake (amount and type) and antral follicle count (AFC). DESIGN: Prospective cohort. SETTING: Academic fertility center. POPULATION: 265 women undergoing fertility treatments at an academic fertility center and participating in an ongoing study on environment and reproductive health. METHODS: We measured AFC in ultrasonographic evaluation among women undergoing infertility treatments...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28278350/the-role-of-the-vaginal-microbiome-in-gynecological-cancer-a-review
#20
REVIEW
Miriam Champer, Alexandra M Wong, Jackson Champer, Ilana L Brito, Philipp W Messer, June Y Hou, Jason D Wright
Human microbiome research has shown commensal bacteria to be a major factor in both wellness and disease pathogenesis. Interest in the microbiome has recently expanded beyond the gut to include a multitude of other organ systems for which the microbiome may have health implications. Here, we review the role of the vaginal microbiome in health and disease, with a particular focus on gynecologic malignancies. Further, we suggest that it may be possible to expand the use of probiotics in the treatment of gynecologic cancers...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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