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International Journal of Colorectal Disease

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https://www.readbyqxmd.com/read/28432444/endoscopic-ultrasonography-and-computed-tomography-scanning-for-preoperative-staging-of-colonic-cancer
#1
M L Malmstrøm, I Gögenur, L B Riis, H Hassan, T W Klausen, T Perner, A Săftoiu, P Vilmann
PURPOSE: With an increasing demand for more accurate preoperative staging methods for colon cancer, we aimed to compare preoperative tumour (T)- and nodal (N)-stage in patients with left-sided colon cancer by endoscopic ultrasonography (EUS) and computed tomography (CT) with post-operative histology as gold standard. METHODS: A total of 44 patients were prospectively recruited at Herlev and Roskilde University Hospitals during November 2014-January 2016. Thirty-five patients were included in the final analysis and underwent EUS, CT and surgery within 2 weeks...
April 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28432443/progastrin-a-potential-predictive-marker-of-liver-metastasis-in-colorectal-cancer
#2
David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin
BACKGROUND AND AIMS: Staging of colorectal cancer often fails to discriminate outcomes of patients with morphologically similar tumours that exhibit different clinical behaviours. Data from several studies suggest that the gastrin family of growth factors potentiates colorectal cancer tumourigenesis. The aim of this study was to investigate whether progastrin expression may predict clinical outcome in colorectal cancer. METHODS: Patients with colorectal adenocarcinoma of identical depth of invasion who had not received neoadjuvant therapy were included...
April 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28429071/the-surgical-management-of-radiation-proctopathy
#3
REVIEW
L F McCrone, P M Neary, J Larkin, P McCormick, B Mehigan
BACKGROUND: There is sparse evidence guiding the optimum surgical management of patients with radiation proctopathy (RP). The purpose of this review is to analyse all the literature on the surgical management of RP in order to guide physicians and surgeons as to when and what surgery should be employed for these patients. METHODS: A literature search of PubMed, EMBASE, MEDLINE, Ovid, and Cochrane Library using the MeSH terms "radiation proctopathy", "proctitis", "surgical management", and related terms as keywords was performed...
April 20, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28424872/percutaneous-endoscopic-sigmoidopexy-using-t-fasteners-for-management-of-sigmoid-volvulus
#4
Kevin Tin, Zain A Sobani, Nnaemeka Anyadike, Anna Serur, Ira Mayer, Kadirawel Iswara, Yuriy Tsirlin
BACKGROUND: Sigmoid volvulus (SV) is the third leading cause of large bowel obstruction after colonic neoplasms and diverticular disease. SV has traditionally been managed via endoscopic detorsion and decompression followed by non-emergent surgical resection owing to the high risk of recurrence. Most cases of SV occur in elderly debilitated patients with multiple comorbidities and may not be candidates for surgical resection. Endoscopic sigmoidopexy has been described as an alternative to surgical resection...
April 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28424871/final-analysis-of-the-randomised-peak-trial-overall-survival-and-tumour-responses-during-first-line-treatment-with-mfolfox6-plus-either-panitumumab-or-bevacizumab-in-patients-with-metastatic-colorectal-carcinoma
#5
Fernando Rivera, Meinolf Karthaus, J Randolph Hecht, Isabel Sevilla, Frédéric Forget, Gianpiero Fasola, Jean-Luc Canon, Xuesong Guan, Gaston Demonty, Lee S Schwartzberg
PURPOSE: To report planned final overall (OS) and progression-free survival (PFS) analyses from the phase II PEAK trial (NCT00819780). METHODS: Patients with previously untreated, KRAS exon 2 wild-type (WT) metastatic colorectal cancer (mCRC) were randomised to mFOLFOX6 plus panitumumab or bevacizumab. The primary endpoint was PFS; secondary endpoints included OS, objective response rate, duration of response (DoR), time to response, resection and safety. Treatment effect by tumour RAS status was a prespecified objective...
April 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28417196/a-sustaining-rod-increases-necrosis-of-loop-ileostomies-a-randomized-controlled-trial
#6
Joel Zindel, Chantal Gygax, Peter Studer, Melanie Kauper, Daniel Candinas, Vanessa Banz, Lukas E Brügger
PURPOSE: Defunctioning loop ileostomies (LI) are commonly used in colorectal surgery to reduce the potentially detrimental consequences of anastomotic leakages. However, stoma-related morbidity is high with up to 75% of patients having local complications. The aim of this study was to investigate the effect of a sustaining rod on the local complication rate. METHODS: In this prospective, multi-center, randomized controlled trial, subjects were allocated to either a rod or a rod-less protocol (NCT00959738)...
April 18, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28411352/impact-of-postoperative-complications-on-readmission-and-long-term-survival-in-patients-following-surgery-for-colorectal-cancer
#7
Ksenija Slankamenac, Maja Slankamenac, Andrea Schlegel, Antonio Nocito, Andreas Rickenbacher, Pierre-Alain Clavien, Matthias Turina
PURPOSE: It is well known that specific postoperative complications such as stroke influence readmissions and overall survival (OS) after surgery for colorectal cancer (CRC). Whether overall hospital morbidity is associated with increased risk of readmission and poorer long-term survival is unknown. New tools are available to accurately quantify overall morbidity, such as the comprehensive complication index (CCI). The aim is to evaluate the impact of complications on readmission and overall survival (OS) in patients operated for colorectal cancer...
April 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28409270/getting-the-first-degree-relatives-to-screen-for-colorectal-cancer-is-harder-than-it-seems-patients-and-their-first-degree-relatives-perspectives
#8
Ker-Kan Tan, Tian-Zhi Lim, Dedrick Kok Hong Chan, Emily Chew, Wen-Min Chow, Nan Luo, Mee-Lian Wong, Gerald Choon-Huat Koh
INTRODUCTION: First degree relatives (FDR) of colorectal cancer (CRC) patients are at increased risk of CRC compared to the general population. However, screening colonoscopy rates amongst the FDRs remain dismal. The aim of the study was to explore the various issues amongst the patients and their FDR precluding their adoption of screening colonoscopy. METHODS: A qualitative study of CRC patients and their FDRs was performed. Semi-structured interviews were conducted with participants using open-ended questions until data saturation was achieved...
April 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28409269/short-term-outcomes-of-laparoscopic-ventral-rectopexy-for-obstructed-defecation-in-patients-with-overt-pelvic-structural-abnormalities-a-chinese-pilot-study
#9
G Y Ye, Z Wang, K E Matzel, Z Cui
AIM: As laparoscopic ventral rectopexy (LVR) gained increasing popularity in the past decade, studies from non-western area remain rare. The aim of this pilot study is to evaluate the efficacy and safety of LVR for obstructed defecation (OD) in Chinese patients with overt pelvic structural abnormalities. METHODS: A series of 19 consecutive patients is presented undergoing LVR for OD. All patients showed various forms of pelvic structural abnormalities which were verified by dynamic defecography exam...
April 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28409268/laparoscopic-sigmoid-resection-for-diverticulitis-is-rarely-a-suitable-case-for-the-initial-phase-of-the-learning-curve
#10
LETTER
Valerio Celentano
No abstract text is available yet for this article.
April 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28405738/evaluation-of-mir-506-and-mir-4316-expression-in-early-and-non-invasive-diagnosis-of-colorectal-cancer
#11
Paweł Krawczyk, Tomasz Powrózek, Tomasz Olesiński, Adam Dmitruk, Joanna Dziwota, Dariusz Kowalski, Janusz Milanowski
PURPOSE: Examination of the entire colon by colonoscopy remains the golden standard for screening of colorectal cancer (CRC). However, patients are reluctant to perform invasive colonoscopies because of interference with their intimacy. Therefore, the potential use of non-invasive analysis of microRNAs expression in liquid biopsy as a novel biomarker for early CRC has investigated in several studies. In this study, we analyzed the expression of two novel microRNAs: miR-506 and miR-4316, which have never been examined in CRC...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28405737/the-prognostic-significance-of-stapler-doughnuts-examination-at-low-anterior-resection-for-rectal-cancer
#12
LETTER
Eleftherios Spartalis, Demetrios Moris, Antonios Athanasiou, Stylianos Kykalos, Dimitrios Dimitroulis
No abstract text is available yet for this article.
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28401350/peritoneal-fluid-biomarkers-in-the-detection-of-colorectal-anastomotic-leaks-a-systematic-review
#13
REVIEW
Emma C Wright, Patricia Connolly, Mark Vella, Susan Moug
PURPOSE: Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anastomosis may aid early detection. This paper aims to review the evidence for their role in AL detection, allowing identification of targets for future research. METHODS: A systematic review was performed using PubMed, MEDLINE and Cochrane Library databases...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28391449/percutaneous-tibial-nerve-stimulation-ptns-success-rate-and-the-role-of-rectal-capacity
#14
Lukas Marti, Christian Galata, Ulrich Beutner, Franc Hetzer, Nicoletta Pipitone, Katja Wolff, Jan Borovicka, Walter Brunner, Michael Christian Sulz, Christine Maurus
PURPOSE: Percutaneous tibial nerve stimulation (pTNS) was originally developed to treat urinary incontinence. Recently, some case series have also documented its success in the treatment of fecal incontinence. Nevertheless, the mechanism underlying this effect remains unknown but may be related to changes in rectal capacity. The aim of this study was to investigate the success of pTNS for the treatment of fecal urge incontinence and assess the influence of rectal capacity on treatment efficacy...
April 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28391448/type-of-incision-does-not-predict-abdominal-wall-outcome-after-emergency-surgery-for-colonic-anastomotic-leakage
#15
Kristian Kiim Jensen, Erling Oma, Henrik Harling, Peter-Martin Krarup
PURPOSE: Most literature on abdominal incision is based on patients undergoing elective surgery. In a cohort of patients with anastomotic leakage after colonic cancer resection, we analyzed the association between type of incision, fascial dehiscence, and incisional hernia. METHODS: Data were extracted from the Danish Colorectal Cancer Group database and merged with information from the Danish National Patient Register. All patients with anastomotic leakage after colonic resection in Denmark from 2001 until 2008 were included and surgical records on re-operations were retrieved...
April 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28389779/poor-prognosis-of-young-patients-with-colorectal-cancer-a-retrospective-study
#16
Liying Zhao, Feng Bao, Jun Yan, Hao Liu, Tingting Li, Hao Chen, Guoxin Li
PURPOSE: The present study aimed to explore the survival outcomes of patients with colorectal cancer (CRC) aged 35 years and younger. METHODS: This retrospective cohort study included a total of 995 patients with CRC treated between January 2003 and September 2011. The patients were assorted into the young (aged 18-35 years) and older (aged 36-75 years) groups. The clinical characteristics and survival outcomes of the patients in the young group were compared with those of the patients in the older group for evaluation...
April 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28389778/resection-enterostomy-versus-hartmann-s-procedure-for-emergency-colonic-resections
#17
M Grott, K Horisberger, C Weiß, P Kienle, J Hardt
BACKGROUND: If a primary anastomosis is considered too risky after emergency colon resection either a resection enterostomy or an end stoma with closure of the distal bowel (Hartmann's procedure) is possible. This study analyzes the rate of restoration of intestinal continuity and other surgical outcomes after resection enterostomy placement versus Hartmann's procedure for emergency colon resections. METHODS: All patients who underwent emergency colorectal resections between August 2009 and June 2014 at the University Medical Center Mannheim were reviewed in regard to therapeutic approach, rate of restoration of bowel continuity, and surgical morbidity after the primary operation and after reversal surgery...
April 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28386662/inflammatory-markers-as-early-predictors-of-infection-after-colorectal-surgery-the-same-cut-off-values-in-laparoscopy-and-laparotomy
#18
Olivier Facy, Brice Paquette, David Orry, Nicolas Santucci, Paul Rat, Patrick Rat, Christine Binquet, Pablo Ortega-Deballon
PURPOSE: C-reactive protein and procalcitonin are reliable early predictors of infection after colorectal surgery. However, the inflammatory response is lower after laparoscopy as compared to open surgery. This study analyzed whether a different cutoff value of inflammatory markers should be chosen according to the surgical approach. METHODS: A prospective, observational study included consecutive patients undergoing elective colorectal surgery in three academic centers...
April 6, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28382511/long-term-outcomes-after-resection-of-para-aortic-lymph-node-metastasis-from-left-sided-colon-and-rectal-cancer
#19
Nozomu Nakai, Tomohiro Yamaguchi, Yusuke Kinugasa, Akio Shiomi, Hiroyasu Kagawa, Yushi Yamakawa, Masakatsu Numata, Akinobu Furutani
PURPOSE: Para-aortic lymph node (PALN) metastasis from colorectal cancer is rare and often not suitable for surgery. However, in selected patients, radical resection may bring about longer survival. The aim of this study was to evaluate long-term outcomes of resection of left-sided colon or rectal cancer with simultaneous PALN metastasis. METHODS: The study included 2122 patients with left-sided colon or rectal cancer (30 patients with and 2092 patients without PALN metastasis) who underwent resection with curative intent between 2002 and 2013...
April 5, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28378155/preservation-of-the-superior-rectal-artery-influence-of-surgical-technique-on-anastomotic-healing-and-postoperative-morbidity-in-laparoscopic-sigmoidectomy-for-diverticular-disease
#20
Maximilian Sohn, H J Schlitt, M Hornung, C Zülke, A Hochrein, C Moser, A Agha
PURPOSE: To evaluate the impact of superior rectal artery (SRA) sparing technique on anastomotic leakage in laparoscopic sigmoidectomy for diverticular disease. MATERIAL AND METHODS: A retrospective multicenter analysis of all patients undergoing laparoscopic sigmoid resection for diverticular disease between 2002 and 2015 was conducted. Data were recorded in three hospitals: University Hospital Regensburg, Marienhospital Gelsenkirchen, and Städtisches Klinikum München Bogenhausen...
April 4, 2017: International Journal of Colorectal Disease
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