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American Journal of Gastroenterology

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https://www.readbyqxmd.com/read/29557942/development-and-validation-of-a-patient-reported-outcome-measurement-for-symptom-assessment-in-cirrhotic-ascites
#1
Myrte Neijenhuis, Tom J G Gevers, Thomas D Atwell, Tim J Gunneson, Amanda C Schimek, Wietske Kievit, Joost P H Drenth, Patrick S Kamath
OBJECTIVES: As current treatments of cirrhotic ascites are not associated with survival benefit, symptom relief is the major therapeutic end point. We developed a questionnaire (Ascites-Q; modified polycystic liver disease questionnaire) and assessed validity and responsiveness for symptom assessment in cirrhotic ascites. METHODS: Ascites-Q was compared with Functional Assessment of Chronic Illness Therapy-Ascites Index (FACIT-AI; developed for malignant ascites) and Japanese Ascites Symptom Inventory-7 (ASI-7) in cirrhotics undergoing large-volume paracentesis...
March 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29549358/thoughts-on-time-constraints-and-bedside-skills
#2
Arvey I Rogers, Lawrence J Brandt, George W Meyer
No abstract text is available yet for this article.
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29549357/igg4-associated-cholangitis-in-patients-resected-for-presumed-perihilar-cholangiocarcinoma-a-30-year-tertiary-care-experience
#3
Eva Roos, Lowiek M Hubers, Robert J S Coelen, Marieke E Doorenspleet, Niek de Vries, Joanne Verheij, Ulrich Beuers, Thomas M van Gulik
BACKGROUND: Distinguishing perihilar cholangiocarcinoma (PHC) from benign forms of sclerosing cholangitis affecting the hilar bile ducts is challenging, since histological confirmation of PHC is difficult to obtain and accurate non-invasive diagnostic tests are not available. IgG4-associated cholangitis (IAC), an imitator of PHC, may present with clinical and radiographical signs of PHC. IAC can be accurately diagnosed with a novel qPCR test. The aim of this study was to investigate the incidence and long-term activity of IAC in patients resected for PHC in a single tertiary center over a period of 30 years...
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29549356/the-management-of-incidental-fatty-liver-found-on-imaging-what-do-we-need-to-do
#4
Nahum Méndez-Sánchez, Norberto C Chavez-Tapia, Paloma Almeda-Valdes, Misael Uribe
No abstract text is available yet for this article.
March 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29545635/efficacy-safety-and-tolerability-of-plecanatide-in-patients-with-irritable-bowel-syndrome-with-constipation-results-of-two-phase-3-randomized-clinical-trials
#5
Darren M Brenner, Ronald Fogel, Spencer D Dorn, Richard Krause, Paul Eng, Robert Kirshoff, Anhthu Nguyen, Robert A Crozier, Leslie Magnus, Patrick H Griffin
OBJECTIVES: Two identical, phase 3, randomized, double-blind, placebo-controlled trials evaluated the efficacy and safety of plecanatide in patients with irritable bowel syndrome with constipation (IBS-C). METHODS: Adults meeting Rome III criteria for IBS-C were randomized (1:1:1) to placebo or plecanatide (3 or 6 mg) for 12 weeks. The primary efficacy end point was the percentage of overall responders (patients reporting ≥30% reduction from baseline in worst abdominal pain plus an increase of ≥1 complete spontaneous bowel movement (CSBM)/week from baseline in the same week for ≥6 of 12 treatment weeks)...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29545634/the-pancreatitis-activity-scoring-system-predicts-clinical-outcomes-in-acute-pancreatitis-findings-from-a-prospective-cohort-study
#6
James Buxbaum, Michael Quezada, Bradford Chong, Nikhil Gupta, Chung Yao Yu, Christianne Lane, Ben Da, Kenneth Leung, Ira Shulman, Stephen Pandol, Bechien Wu
OBJECTIVES: The Pancreatitis Activity Scoring System (PASS) has been derived by an international group of experts via a modified Delphi process. Our aim was to perform an external validation study to assess for concordance of the PASS score with high face validity clinical outcomes and determine specific meaningful thresholds to assist in application of this scoring system in a large prospectively ascertained cohort. METHODS: We analyzed data from a prospective cohort study of consecutive patients admitted to the Los Angeles County Hospital between March 2015 and March 2017...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29545633/chronic-nausea-and-vomiting-evaluation-and-treatment
#7
REVIEW
Brian E Lacy, Henry P Parkman, Michael Camilleri
Nausea is an uneasy feeling in the stomach while vomiting refers to the forceful expulsion of gastric contents. Chronic nausea and vomiting represent a diverse array of disorders defined by 4 weeks or more of symptoms. Chronic nausea and vomiting result from a variety of pathophysiological processes, involving gastrointestinal and non-gastrointestinal causes. The prevalence of chronic nausea and vomiting is unclear, although the epidemiology of specific conditions, such as gastroparesis and cyclic vomiting syndrome, is better understood...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29545632/helicobacter-pylori-infection-does-not-protect-against-eosinophilic-esophagitis-results-from-a-large-multicenter-case-control-study
#8
Javier Molina-Infante, Carolina Gutierrez-Junquera, Edoardo Savarino, Roberto Penagini, Ines Modolell, Ottavia Bartolo, Alicia Prieto-García, Aurelio Mauro, Javier Alcedo, Antonia Perelló, Carlos Guarner-Argente, Noelia Alcaide, Ana M Vegas, Patricia Barros-García, Marianette Murzi-Pulgar, Monica Perona, Javier P Gisbert, Alfredo J Lucendo
OBJECTIVES: Rising trends in eosinophilic esophagitis (EoE) have been repeatedly linked to declining Helicobacter pylori (H. pylori) infection, mostly in retrospective studies. We aimed to prospectively evaluate this inverse association. METHODS: Prospective case-control study conducted in 23 centers. Children and adults naïve to eradication therapy for H. pylori were included. Cases were EoE patients, whereas controls were defined by esophageal symptoms and <5 eos/HPF on esophageal biopsies...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535417/childhood-body-mass-index-and-risk-of-inflammatory-bowel-disease-in-adulthood-a-population-based-cohort-study
#9
Camilla B Jensen, Lars H Ängquist, Michael A Mendall, Thorkild I A Sørensen, Jennifer L Baker, Tine Jess
BACKGROUND: The increasing incidence of inflammatory bowel disease (IBD) in western countries has led to the hypothesis that obesity-related inflammation could play a role in the etiology of IBD. However, this hypothesis lacks confirmation in studies of individuals prior to the typical onset of IBD in young adulthood. METHODS: In a cohort of 316,799 individuals from the Copenhagen School Health Records Register (CSHRR), we examined whether BMI at ages 7 through 13 years was associated with later IBD...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535416/genetic-variants-in-pnpla3-and-tm6sf2-predispose-to-the-development-of-hepatocellular-carcinoma-in-individuals-with-alcohol-related-cirrhosis
#10
Felix Stickel, Stephan Buch, Hans Dieter Nischalke, Karl Heinz Weiss, Daniel Gotthardt, Janett Fischer, Jonas Rosendahl, Pierre Deltenre, Astrid Marot, Mona Elamly, Markus Casper, Frank Lammert, Andrew McQuillin, Steffen Zopf, Ulrich Spengler, Silke Marhenke, Martha M Kirstein, Arndt Vogel, Florian Eyer, Johann von Felden, Henning Wege, Thorsten Buch, Clemens Schafmayer, Felix Braun, Thomas Berg, Marsha Y Morgan, Jochen Hampe
OBJECTIVES: Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926), and membrane bound O-acyltransferase domain containing 7 (MBOAT7; rs641738) are risk factors for the development of alcohol-related cirrhosis. Within this population, PNPLA3 rs738409 is also an established risk factor for the development of hepatocellular carcinoma (HCC). The aim of this study was to explore possible risk associations of TM6SF2 rs58542926 and MBOAT7 rs641738 with HCC...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535415/response-to-alkhatib-and-alasadi
#11
LETTER
Allison R Schulman, Christopher C Thompson
No abstract text is available yet for this article.
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29535414/acute-pancreatitis-with-long-term-celecoxib-vs-ibuprofen-or-naproxen-data-from-the-precision-trial
#12
LETTER
Neville D Yeomans, David Y Graham, Qiuqing Wang, Kathy Wolski, Jeffrey Borer, M Elaine Husni, Peter Libby, A Michael Lincoff, Thomas Lüscher, Lisa M Wisniewski, Warren Bao, Chris Walker, Steven E Nissen
No abstract text is available yet for this article.
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29533398/identification-of-individuals-with-functional-dyspepsia-with-a-simple-minimally-invasive-test-a-single-center-cohort-study-of-the-oral-capsaicin-test
#13
Johann Hammer
OBJECTIVES: The diagnosis of functional dyspepsia (FD) is challenging due to the lack of reliable biological markers to support the diagnosis. We assessed the relevance of a previously validated simple test for chemical hypersensitivity in the setting of a gastrointestinal outpatient department. METHODS: A total of 224 outpatients who were referred for evaluation of gastrointestinal symptoms in the absence of alarm symptoms swallowed a capsule containing 0.75 mg capsaicin...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29533397/same-day-single-dose-of-2-liter-polyethylene-glycol-is-not-inferior-to-the-standard-bowel-preparation-regimen-in-low-risk-patients-a-randomized-controlled-trial
#14
Xiaoyu Kang, Lina Zhao, Zhiyong Zhu, Felix Leung, Limei Wang, Xiangping Wang, Hui Luo, Linhui Zhang, Tao Dong, Pingying Li, Zhangqin Chen, Gui Ren, Hui Jia, Xiaoyang Guo, Yanglin Pan, Xuegang Guo, Daiming Fan
OBJECTIVES: Split dose of 4 l polyethylene glycol (PEG) is currently the standard regimen for bowel preparation (BP). However, it may be unnecessary for patients without high risks (e.g., old age, constipation, and diabetes, and so on) for inadequate BP. The study aimed to compare the efficacy of bowel cleansing between low-risk patients receiving same-day, single dose of low-volume (SSL) PEG vs. standard regimen. METHODS: This prospective, randomized, observer-blinded, non-inferiority study enrolled low-risk patients in three centers...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29533396/diagnosis-of-minimal-hepatic-encephalopathy-a-systematic-review-of-point-of-care-diagnostic-tests
#15
REVIEW
Elliot B Tapper, Neehar D Parikh, Akbar K Waljee, Michael Volk, Noelle E Carlozzi, Anna S-F Lok
OBJECTIVES: Minimal hepatic encephalopathy (HE) is common, characterized by deficits in reaction time and executive function, and strongly associated with disability and mortality. Point-of-care diagnostics performed without specialized skills or equipment are now available, albeit with limited data regarding their generalizability. METHODS: We systematically reviewed MEDLINE, EMBASE, Cochrane Library, and Scopus for diagnostic studies of MHE using broad search terms including HE and minimal, covert, or the names of published diagnostic modalities...
March 13, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29531307/mucosal-luminal-interface-proteomics-reveals-biomarkers-of-pediatric-inflammatory-bowel-disease-associated-colitis
#16
Shelley A Deeke, Amanda E Starr, Zhibin Ning, Sara Ahmadi, Xu Zhang, Janice Mayne, Cheng-Kang Chiang, Ruth Singleton, Eric I Benchimol, David R Mack, Alain Stintzi, Daniel Figeys
OBJECTIVE: Improved biomarkers are an unmet clinical need for suspected inflammatory bowel disease (IBD). Need is greatest for children, since current biomarkers suffers from low specificity, particularly in this population; thus, invasive testing methods, with the accompanying risk of complications, are necessary. Additionally, current biomarkers do not delineate disease extent assessment for ulcerative colitis (UC), a factor involved in therapeutic decisions. METHODS: Intestinal mucosal-luminal interface (MLI) aspirates from the ascending colon (AC) and descending colon (DC) were collected during diagnostic colonoscopy from treatment-naïve children...
March 12, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29523867/dos-and-don-ts-in-the-management-of-cirrhosis-a-view-from-the-21st-century
#17
Mary J Thomson, Elliot B Tapper, Anna S F Lok
No abstract text is available yet for this article.
March 9, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29523866/bleeding-granuloma-pyogenicum-in-rectum
#18
Saroj Kant Sinha, Neha Berry, Kaushal Kishor Prasad, Parul Sarwal, Narendra Dhaka, Rakesh Kochhar
No abstract text is available yet for this article.
March 9, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29523865/response-to-marlicz-et-al
#19
LETTER
Paul Moayyedi, Brian E Lacy, Christopher N Andrews, Robert A Enns, Colin W Howden, Nimish Vakil
No abstract text is available yet for this article.
March 9, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29523864/race-ethnicity-and-insurance-status-disparities-in-access-to-direct-acting-antivirals-for-hepatitis-c-virus-treatment
#20
Robert J Wong, Mamta K Jain, George Therapondos, Mitchell L Shiffman, Onkar Kshirsagar, Christopher Clark, Mae Thamer
OBJECTIVE: Despite availability of highly effective direct acting antivirals (DAA), barriers in access to these therapies limit our ability to achieve HCV eradication. We aim to evaluate overall rates and predictors of HCV treatment across four community-based health-care systems focusing on race/ethnicity and insurance-specific disparities. METHODS: We retrospectively evaluated all adults with chronic HCV at four health care systems from 1 January 2011 to 28 February 2017, which included a large proportion of ethnic minorities, two safety-net systems, and a broad payer mix across four states...
March 9, 2018: American Journal of Gastroenterology
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