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American Journal of Gastroenterology

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https://www.readbyqxmd.com/read/29476085/defining-the-relationship-between-depression-and-disease-activity-in-ibd-using-clinical-disease-activity-indices-merit-or-misnomer
#1
David J Gracie, Alexander C Ford
No abstract text is available yet for this article.
February 23, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29476084/do-not-leave-fit-positives-alone
#2
LETTER
Manuel Zorzi, Cesare Hassan, Kevin Selby, Massimo Rugge
No abstract text is available yet for this article.
February 23, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29463834/family-history-of-colorectal-cancer-in-first-degree-relatives-and-metachronous-colorectal-adenoma
#3
Elizabeth T Jacobs, Samir Gupta, John A Baron, Amanda J Cross, David A Lieberman, Gwen Murphy, María Elena Martínez
OBJECTIVES: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. METHODS: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. RESULTS: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460921/measuring-change-in-small-intestinal-histology-in-patients-with-celiac-disease
#4
REVIEW
Daniel C Adelman, Joseph Murray, Tsung-Teh Wu, Markku Mäki, Peter H Green, Ciarán P Kelly
Small intestinal histologic abnormalities in celiac disease include atrophy of the intestinal villi, hypertrophy of the crypts and lymphocytic infiltration of intraepithelial spaces and lamina propria. These findings are central to diagnosis and their severity and change over time are valuable to monitor disease course and response to therapy. Subjective methods to grade celiac disease histological severity include the Marsh-Oberhuber and Corazza-Villanacci systems. Quantitative histology uses villus height (Vh), crypt depth (Cd), and intra-epithelial lymphocyte count (per 100 enterocytes) to provide objective measures of histologic changes including Vh:Cd ratio...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460920/long-term-safety-of-in-utero-exposure-to-anti-tnf%C3%AE-drugs-for-the-treatment-of-inflammatory-bowel-disease-results-from-the-multicenter-european-teddy-study
#5
M Chaparro, A Verreth, T Lobaton, E Gravito-Soares, M Julsgaard, E Savarino, F Magro, I Avni Biron, P Lopez-Serrano, M J Casanova, M Gompertz, S Vitor, M Arroyo, D Pugliese, Y Zabana, R Vicente, M Aguas, A Bar-Gil Shitrit, A Gutierrez, G A Doherty, L Fernandez-Salazar, J Martínez Cadilla, J M Huguet, A O'Toole, E Stasi, N Manceñido Marcos, A Villoria, K Karmiris, J F Rahier, C Rodriguez, M Diz-Lois Palomares, G Fiorino, J M Benitez, M Principi, T Naftali, C Taxonera, G Mantzaris, L Sebkova, B Iade, D Lissner, I Ferrer Bradley, A Lopez-San Roman, I Marin-Jimenez, O Merino, M Sierra, M Van Domselaar, F Caprioli, I Guerra, P Peixe, M Piqueras, I Rodriguez-Lago, Y Ber, K van Hoeve, P Torres, M Gravito-Soares, D Rudbeck-Resdal, O Bartolo, A Peixoto, G Martin, A Armuzzi, A Garre, M G Donday, F J Martín de Carpi, J P Gisbert
OBJECTIVES: The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed to compare the relative risk of severe infections in children of mothers with inflammatory bowel disease (IBD) who were exposed to anti-TNFα drugs in utero with that of children who were not exposed to the drugs. METHODS: Retrospective multicenter cohort study. Exposed cohort: children from mothers with IBD receiving anti-TNFα medication (with or without thiopurines) at any time during pregnancy or during the 3 months before conception...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460919/a-role-for-total-pancreatectomy-and-islet-autotransplant-in-the-treatment-of-chronic-pancreatitis
#6
Melena D Bellin
No abstract text is available yet for this article.
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29460918/treatment-of-supragastric-belching-with-cognitive-behavioral-therapy-improves-quality-of-life-and-reduces-acid-gastroesophageal-reflux
#7
E Glasinovic, E Wynter, J Arguero, J Ooi, K Nakagawa, E Yazaki, P Hajek, C Clin Psych, P Woodland, D Sifrim
OBJECTIVES: Excessive supragastric belching (SGB) manifests as troublesome belching, and can be associated with reflux and significant impact on quality of life (QOL). In some GERD patients, SGB-associated reflux contributes to up to 1/3 of the total esophageal acid exposure. We hypothesized that a cognitive-behavioral intervention (CBT) might reduce SGB, improve QOL, and reduce acid gastroesophageal reflux (GOR). We aimed to assess the effectiveness of CBT in patients with pathological SGB...
February 20, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453384/longitudinal-impact-of-ibs-type-symptoms-on-disease-activity-healthcare-utilization-psychological-health-and-quality-of-life-in-inflammatory-bowel-disease
#8
David J Gracie, P John Hamlin, Alexander C Ford
OBJECTIVES: The impact of irritable bowel syndrome (IBS)-type symptoms on the natural history of inflammatory bowel disease (IBD) is uncertain. We aimed to address this in a longitudinal study of secondary care patients. METHODS: Longitudinal disease activity was defined by disease flare, escalation of medical therapy, hospitalization, or intestinal resection. The number of investigations performed and clinics attended determined healthcare utilization. Psychological well-being and quality of life were assessed using validated questionnaires...
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453383/hyperbaric-oxygen-therapy-is-well-tolerated-and-effective-for-ulcerative-colitis-patients-hospitalized-for-moderate-severe-flares-a-phase-2a-pilot-multi-center-randomized-double-blind-sham-controlled-trial
#9
Parambir S Dulai, Jay C Buckey, Laura E Raffals, Jason M Swoger, Paul L Claus, Kevin O'Toole, Judy A Ptak, Michael W Gleeson, Christella E Widjaja, John T Chang, Jeffery M Adler, Nihal Patel, Laurie A Skinner, Shawn P Haren, Kimberly Goldby-Reffner, Kimberly D Thompson, Corey A Siegel
BACKGROUND: Hyperbaric oxygen therapy (HBOT) markedly increases tissue oxygen delivery. Case series suggest it may have a potential therapeutic benefit in ulcerative colitis (UC). We investigated the therapeutic potential of HBOT as an adjunct to steroids for UC flares requiring hospitalization. METHODS: The study was terminated early due to poor recruitment with 18 of the planned 70 patients enrolled. UC patients hospitalized for moderate-severe flares (Mayo score ≥6, endoscopic sub-score ≥2) were block randomized to steroids + daily HBOT (n = 10) or steroids + daily sham hyperbaric air (n = 8)...
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453382/rectal-exam-yes-it-can-and-should-be-done-in-a-busy-practice
#10
Satish S C Rao
No abstract text is available yet for this article.
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453381/choledocholithiasis-in-roux-en-y-gastric-bypass-patients
#11
LETTER
Amer A Alkhatib, Mazen Alasadi
No abstract text is available yet for this article.
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453380/the-intricacies-of-the-mediterranean-diet-in-nafld
#12
LETTER
A Duret, D de Gracia Hahn, H Hunter, Y R Im, J P Mann
No abstract text is available yet for this article.
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29453379/comment-on-systematic-review-and-meta-analysis-by-dube-et-al
#13
LETTER
Paul F Pinsky
No abstract text is available yet for this article.
February 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380823/efficacy-and-tolerability-of-guanylate-cyclase-c-agonists-for-irritable-bowel-syndrome-with-constipation-and-chronic-idiopathic-constipation-a-systematic-review-and-meta-analysis
#14
REVIEW
Eric D Shah, Hyungjin Myra Kim, Philip Schoenfeld
OBJECTIVES: Linaclotide and plecanatide are guanylate cyclase-C (GCC) agonists for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Our objective is to evaluate the efficacy and tolerability of GCC agonists based on data from multiple randomized controlled trials (RCTs). METHODS: We searched PubMED, EMBASE, Cochrane databases, clinicaltrials.gov, major conference abstracts, Food and Drug Administration (FDA) websites, and United States Securities and Exchange Commission filings of drug sponsors to identify RCTs of CIC or IBS-C patients...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380822/hospitalizations-for-autoimmune-hepatitis-disproportionately-affect-black-and-latino-americans
#15
Jason W Wen, Michael A Kohn, Robert Wong, Ma Somsouk, Mandana Khalili, Jacquelyn Maher, Michele M Tana
OBJECTIVES: The healthcare burden of autoimmune hepatitis (AIH) in the United States has not been characterized. We previously showed that AIH disproportionately affects people of color in a single hospital system. The current study aimed to determine whether the same disparity occurs nationwide. METHODS: We analyzed hospitalizations with a primary discharge diagnosis corresponding to the ICD-9 code for AIH in the National Inpatient Sample between 2008 and 2012...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380821/randomized-double-blind-placebo-controlled-crossover-trial-for-the-diagnosis-of-non-celiac-gluten-sensitivity-in-children
#16
R Francavilla, F Cristofori, L Verzillo, A Gentile, S Castellaneta, C Polloni, V Giorgio, E Verduci, E D'Angelo, S Dellatte, F Indrio
OBJECTIVES: Non-celiac gluten sensitivity (NCGS) is characterized by intestinal and extra-intestinal symptoms that are related to the ingestion of gluten in subjects who are not affected by either celiac disease (CD) or wheat allergy (WA). In this multicenter study, we aim for the first time to evaluate the prevalence of NCGS in pediatric subjects with chronic functional gastrointestinal symptoms associated with gluten ingestion using a double-blind placebo-controlled (DBPC) gluten challenge with crossover...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380820/severity-and-outcomes-of-upper-gastrointestinal-bleeding-with-bloody-vs-coffee-grounds-hematemesis
#17
Loren Laine, Stig B Laursen, Liam Zakko, Harry R Dalton, Jing H Ngu, Michael Schultz, Adrian J Stanley
OBJECTIVES: Numerous reviews indicate bloody hematemesis signifies more severe bleeding than coffee-grounds hematemesis. We assessed severity and outcomes related to bleeding symptoms in a prospective study. METHODS: Consecutive patients presenting with hematemesis or melena were categorized as bloody emesis (N=1209), coffee-grounds emesis without bloody emesis (N=701), or melena without hematemesis (N=1069). We assessed bleeding severity (pulse, blood pressure) and predictors of outcome (hemoglobin, risk stratification scores) at presentation, and outcomes of bleeding episodes...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29380819/variation-in-pathologist-classification-of-colorectal-adenomas-and-serrated-polyps
#18
Rebecca A Gourevitch, Sherri Rose, Seth D Crockett, Michele Morris, David S Carrell, Julia B Greer, Reetesh K Pai, Robert E Schoen, Ateev Mehrotra
OBJECTIVES: Endoscopist quality measures such as adenoma detection rate (ADR) and serrated polyp detection rates (SPDRs) depend on pathologist classification of histology. Although variation in pathologic interpretation is recognized, we add to the literature by quantifying the impact of pathologic variability on endoscopist performance. METHODS: We used natural language processing to abstract relevant data from colonoscopy and related pathology reports performed over 2 years at four clinical sites...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29336434/acg-clinical-guideline-alcoholic-liver-disease
#19
Ashwani K Singal, Ramon Bataller, Joseph Ahn, Patrick S Kamath, Vijay H Shah
Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of patients with early disease are limited. Diagnosis of ALD requires documentation of chronic heavy alcohol use and exclusion of other causes of liver disease. Prolonged abstinence is the most effective strategy to prevent disease progression. AH presents with rapid onset or worsening of jaundice, and in severe cases may transition to acute on chronic liver failure when the risk for mortality, depending on the number of extra-hepatic organ failures, may be as high as 20-50% at 1 month...
January 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29336433/eosinophilic-esophagitis-relationship-of-subepithelial-eosinophilic-inflammation-with-epithelial-histology-endoscopy-blood-eosinophils-and-symptoms
#20
Alain M Schoepfer, Audrey Simko, Christian Bussmann, Ekaterina Safroneeva, Marcel Zwahlen, Thomas Greuter, Luc Biedermann, Stephan Vavricka, Sébastien Godat, Antoine Reinhard, Catherine Saner, Hugo Maye, Christine Sempoux, Christophe Brunel, Carine Blanchard, Dagmar Simon, Hans-Uwe Simon, Alex Straumann
OBJECTIVES: For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histologic findings, endoscopic features, and symptoms. METHODS: Adult patients with established EoE diagnosis were prospectively included during a yearly follow-up visit...
January 16, 2018: American Journal of Gastroenterology
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