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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://www.readbyqxmd.com/read/29905973/effects-of-teriparatide-and-vibration-on-bone-mass-and-bone-strength-in-people-with-bone-loss-and-spinal-cord-injury-a-randomized-controlled-trial
#1
W Brent Edwards, Narina Simonian, Ifaz T Haider, Alan S Anschel, David Chen, Keith E Gordon, Elaine K Gregory, Ki H Kim, Ramadevi Parachuri, Karen L Troy, Thomas J Schnitzer
Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either: teriparatide 20 µg/day plus sham vibration 10 min/day (n = 20), placebo plus vibration 10 min/day (n = 20), or teriparatide 20 µg/day plus vibration 10 min/day (n = 21). Patients were evaluated for 12 months; those who completed were given the opportunity to participate in an open-label extension where all participants (n = 25) received teriparatide 20 µg/day for an additional 12 months and had the optional use of vibration (10 min/day)...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905970/neurexin-superfamily-cell-membrane-receptor-contactin-associated-protein-like-4-cntnap4-is-involved-in-neural-egfl-like-1-nell-1-responsive-osteogenesis
#2
Chenshuang Li, Zhong Zheng, Pin Ha, Xiaoyan Chen, Wenlu Jiang, Shan Sun, Feng Chen, Greg Asatrian, Emily A Berthiaume, Jong Kil Kim, Eric C Chen, Shen Pang, Xinli Zhang, Kang Ting, Chia Soo
Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release that is associated with severe, highly penetrant, repetitive, and perseverative movements commonly found in human autism spectrum disorder patients. However, no known function of Cntnap4 has been revealed besides the nervous system...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905969/vitamin-d-supplementation-in-elderly-black-women-does-not-prevent-bone-loss-a-randomized-controlled-trial
#3
John F Aloia, Melissa Fazzari, Shahidul Islam, Mageda Mikhail, Subhashini Katumuluwa, Ruban Dhaliwal, Alexandra Stolberg, Gianina Usera, Louis Ragolia
Black Americans have lower levels of serum 25(OH)D but superior bone health compared to white Americans. There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM). The purpose of this trial was to determine whether Vitamin D supplementation in elderly black women prevents bone loss. 260 healthy black American women, 60 years of age and older were recruited to take part in a two arm, double-dummy 3 year RCT of vitamin D3 vs...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905968/skeletal-consequences-of-nephropathic-cystinosis
#4
Pablo Florenzano, Carlos Ferreira, Galina Nesterova, Mary Scott Ramnitz, Sri Harsha Tella, Luis Fernandez de Castro, Sydney M Brown, Adom Whitaker, Renata C Pereira, Dorothy Bulas, Rachel I Gafni, Isidro B Salusky, William A Gahl, Michael T Collins
Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. We performed systematic bone and mineral evaluations of subjects with cystinosis seen at the NIH (N = 30), including history and physical examination, serum and urine biochemistries, DXA, vertebral fracture assessment, skeletal radiographs, and renal ultrasound...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29893999/folliculin-regulates-osteoclastogenesis-through-metabolic-regulation
#5
Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
Osteoclast differentiation is a dynamic differentiation process, which is accompanied by dramatic changes in metabolic status as well as in gene expression. Recent findings have revealed an essential connection between metabolic reprogramming and dynamic gene expression changes during osteoclast differentiation. However, the upstream regulatory mechanisms that drive these metabolic changes in osteoclastogenesis remain to be elucidated. Here we demonstrate that induced deletion of a tumor suppressor gene, Folliculin (Flcn), in mouse osteoclast precursors causes severe osteoporosis in 3 weeks through excess osteoclastogenesis...
June 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29893993/normative-standards-for-hrpqct-parameters-in-chinese-men-and-women
#6
Tracy Y Zhu, Benjamin Hk Yip, Vivian Wy Hung, Carol Wy Choy, Ka-Lo Cheng, Timothy Cy Kwok, Jack Cy Cheng, Ling Qin
Assessing bone architecture using high resolution peripheral quantitative computed tomography (HRpQCT) has the potential to improve fracture risk assessment. The Normal Reference Study aimed to establish sex-specific reference centile curves for HRpQCT parameters. This was an age-stratified cross-sectional study and 1,072 ambulatory Chinese men (n = 544) and women (n = 528) aged 20-79yrs, who were free from conditions and medications that could affect bone metabolism and had no history of fragility fracture, were recruited from local communities of Hong Kong...
June 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29878519/phenotypic-consequences-of-plod2-mutations-in-bruck-syndrome-inform-a-collagen-lysyl-hydroxylase-crystal-structure
#7
LETTER
Hou-Fu Guo, Jonathan Kurie
No abstract text is available yet for this article.
June 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29878514/hypocitraturia-is-an-untoward-side-effect-of-synthetic-human-parathyroid-hormone-hpth-1-34-therapy-in-hypoparathyroidism-that-may-increase-renal-morbidity
#8
Rachel I Gafni, Craig B Langman, Lori C Guthrie, Beth A Brillante, Robert James, Nancy A Yovetich, Alison M Boyce, Michael T Collins
Subcutaneous human parathyroid hormone (hPTH) therapy can effectively manage hypocalcemia in hypoparathyroidism, with varying effects on hypercalciuria. However, little is known about its ability to decrease the renal comorbidities of hypoparathyroidism: nephrocalcinosis (NC), nephrolithiasis (NL), and renal insufficiency. Urinary citrate (Ucit) promotes the solubility of urinary calcium (UCa); hypocitraturia is a risk factor for NC/NL. Twenty-four hour UCa, Ucit, and UCa/Ucit were determined in 31 hypoparathyroid patients receiving hPTH 1-34 therapy for up to 5 years...
June 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29878396/genotype-phenotype-correlation-of-plod2-skeletal-dysplasias-using-structural-information
#9
LETTER
Emma Tham, Gintautas Grigelionis, Anna Hammarsjö, Giedre Grigelioniene
No abstract text is available yet for this article.
June 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29852535/suppression-of-bone-resorption-by-mir-141-in-aged-rhesus-monkeys
#10
Shihua Yang, Wenhui Zhang, Mingxiang Cai, Yuanxu Zhang, Fujun Jin, Sen Yan, Zulqurain Baloch, Zhihao Fang, Senren Xue, Rongping Tang, Jia Xiao, Qunshan Huang, Yao Sun, Xiaogang Wang
Aging-related osteoporosis is considered as serious public health concern. Approximately 30% of postmenopausal women suffer from osteoporosis, and more than 40% of them risk fragility fractures. Multiple types of drugs have been applied to treat osteoporosis, but they are not ideal due to insufficient curing and adverse side effects. miRNA-based gene therapy is a rapidly developed strategy in disease treatment that presents certain advantages, such as large-scale production, genetic safety and rapid effects...
May 31, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29813187/skeletal-response-to-soluble-activin-receptor-type-iib-in-mouse-models-of-osteogenesis-imperfecta
#11
Youngjae Jeong, Salah A Daghlas, Xie Yixia, Molly A Hulbert, Ferris M Pfeiffer, Mark R Dallas, Catherine L Omosule, R Scott Pearsall, Sarah L Dallas, Charlotte L Phillips
Osteogenesis imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen genes (COL1A1 and COL1A2), leading to compromised biomechanical integrity in type I collagen containing tissues such as bone. Bone is inherently mechanosensitive and thus responds and adapts to external stimuli, such as muscle mass and contractile strength, to alter its mass and shape. Myostatin, a member of the TGF-β superfamily, signals through activin receptor type IIB to negatively regulate muscle fiber growth...
May 29, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29813186/osteogenic-and-chondrogenic-master-genes-expression-is-dependent-on-the-kir2-1-potassium-channel-through-the-bone-morphogenetic-protein-pathway
#12
Jonathan Pini, Serena Giuliano, Julia Matonti, Dina Simkin, Matthieu Rouleau, Saïd Bendahhou
Andersen's syndrome is a rare disorder affecting muscle, heart, and bone, that is associated with mutations leading to a loss of function of the inwardly rectifying K+ channel Kir2.1. While the Kir2.1 function can be anticipated in excitable cells by controlling the electrical activity, its role in non-excitable cells remains to be investigated. Using Andersen's syndrome induced Pluripotent Stem cells, we investigated the cellular and molecular events during the osteoblastic and chondrogenic differentiation that are affected by the loss of the Ik1 current...
May 29, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29813182/long-term-and-recent-weight-change-are-associated-with-reduced-peripheral-bone-density-deficits-in-bone-microarchitecture-and-decreased-bone-strength-the-framingham-osteoporosis-study
#13
Ching-Ti Liu, Shivani Sahni, Hanfei Xu, Robert R McLean, Kerry E Broe, Marian T Hannan, Steven K Boyd, Mary L Bouxsein, Douglas P Kiel, Elizabeth J Samelson
BACKGROUND: Weight loss in older adults is associated with increased bone loss and fracture. Little is known about the potential impact of weight loss on cortical and trabecular bone density, microarchitecture, and strength. METHODS: Participants were members of the Framingham Offspring Cohort (769 women, 595 men; mean age 70× ± 8 years), who underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) scanning at the tibia and radius in 2012-2016...
May 29, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29786884/bone-morbidity-and-recovery-in-children-with-acute-lymphoblastic-leukemia-results-of-a-six-year-prospective-cohort-study
#14
Leanne M Ward, Jinhui Ma, Bianca Lang, Josephine Ho, Nathalie Alos, Mary Ann Matzinger, Nazih Shenouda, Brian Lentle, Jacob L Jaremko, Beverly Wilson, David Stephure, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Victor Lewis, Sara Israels, Ronald M Grant, Conrad V Fernandez, David B Dix, Elizabeth A Cummings, Robert Couch, Elizabeth Cairney, Ronald Barr, Sharon Abish, Stephanie A Atkinson, John Hay, Frank Rauch, David Moher, Kerry Siminoski, Jacqueline Halton
Osteoporotic fractures are a significant cause of morbidity in acute lymphoblastic leukemia (ALL). Our objective was to determine the incidence and predictors of fractures and recovery from osteoporosis in pediatric ALL over 6 years following glucocorticoid initiation. Vertebral fractures (VF) and vertebral body reshaping were assessed on annual spine radiographs, low-trauma non-VF were recorded at regular intervals and spine bone mineral density (BMD) was captured every 6 months for 4 years and then annually...
May 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750848/accelerated-bone-loss-in-older-men-effects-on-bone-microarchitecture-and-strength
#15
J A Cauley, A J Burghardt, S L Harrison, P M Cawthon, A V Schwartz, E Barrett Connor, Kristine E Ensrud, Lisa Langsetmo, S Majumdar, E Orwoll
Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high resolution peripheral quantitative computed tomography (HR-pQCT) scans (SCANCO, Inc., Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750843/vertebral-fractures-and-morphometric-deformities
#16
LETTER
Brian C Lentle, Edwin Oei, David Goltzman, Fernando Rivadeneira, Ian Hammond, Ling Oei, Christopher S Kovacs, David A Hanley, Jerilynn C Prior, William D Leslie, Stephanie M Kaiser, Jonathan D Adachi, L Probyn, Jacques Brown, Angela M Cheung, Tanveer Towheed
Dear Dr. Civitelli, In discussing such advances, they include spinal morphometry, and specifically refer to and illustrate the Genant semi-quantitative (GSQ) paradigm,2 although also referring to the algorithm-based qualitative (ABQ) method3 of vertebral evaluation in the diagnosis of osteoporotic vertebral fractures (OVF). Although in its day the GSQ method was a credible attempt at structured reporting, recent data suggest that GSQ Grade 1 lesions, the most common, relate less well to bone density and fracture risk than comparable fractures diagnosed using the ABQ tool...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750841/high-serum-serotonin-predicts-increased-risk-for-hip-fracture-and-nonvertebral-osteoporotic-fractures-the-mros-sweden-study
#17
Hallgerdur Lind Kristjansdottir, Catharina Lewerin, Ulf H Lerner, Ewa Waern, Helena Johansson, Daniel Sundh, Magnus Karlsson, Steve R Cummings, Henrik Zetterberg, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
Because several studies have implicated serotonin as a regulator of bone mass, we here explore its potential association on fracture risk and falls, as on bone mineral density (BMD) and muscle strength, in humans. Serum levels of serotonin were analyzed in 950 men (aged 69 to 81 years), participating in the Gothenburg part of the population-based study MrOS Sweden. Men taking selective serotonin reuptake inhibitors (SSRIs) had a mean value of 31.2 μg/L compared with 159.4 μg/L in those not taking SSRIs...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750839/association-between-body-mass-index-and-the-risk-of-hip-fracture-by-sex-and-age-a-prospective-cohort-study
#18
Se Hwa Kim, Sang-Wook Yi, Jee-Jeon Yi, Yoo Mee Kim, Young Jun Won
The association between body mass index (BMI) and hip fracture may differ by ethnic group. We examined the association between BMI and hip fracture according to sex and age, and to identify BMI ranges associated with the lowest risk in Korean men and women. We followed-up 288,068 Korean adults (age, 50-80 years), who underwent health examinations in 2002-2003, to 2013; we examined national hospital discharge records. Hazard ratios (HRs) were calculated using Cox proportional hazard models after adjusting for confounders...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750836/assessment-of-cortical-interruptions-with-semi-automated-analysis-of-hr-pqct-images-in-finger-joints-of-patients-with-rheumatoid-arthritis-versus-healthy-subjects-and-in-comparison-to-radiography-and-mri
#19
M Peters, A van Tubergen, A Scharmga, J H M Driessen, B van Rietbergen, D Loeffen, R Weijers, P Geusens, J P van den Bergh
OBJECTIVES: Small cortical interruptions may be the first sign of an erosion, and more interruptions can be found in patients with rheumatoid arthritis (RA) compared to healthy subjects (HS). Therefore, we, first, compared the number and size of interruptions in patients with RA to HS using high-resolution peripheral quantitative CT (HR-pQCT). Second, we investigated the association between structural damage and inflammatory markers on conventional radiography (CR) and MRI with interruptions on HR-pQCT...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750835/lrp1-suppresses-bone-resorption-in-mice-by-inhibiting-the-rankl-stimulated-nf%C3%AE%C2%BAb-and-p38-pathways-during-osteoclastogenesis
#20
Di Lu, Jianshuang Li, Huadie Liu, Gabrielle E Foxa, Kevin Weaver, Jie Li, Bart O Williams, Tao Yang
Single nucleotide polymorphisms in the LRP1 gene coding sequence are associated with low bone mass, and cell culture studies suggest that LRP1 plays a role in osteoblast proliferation and osteoblast-mediated osteoclastogenesis. However, the in vivo function of LRP1 in bone homeostasis has not been explored. In this work, we studied the osteoclast-specific role of LRP1 in bone homeostasis using a Ctsk-Cre;Lrp1f/f mouse model on the C57BL/6J background. These mice had a dramatically decreased trabecular bone mass with markedly more osteoclasts, while the osteoblast activity was unaffected or slightly increased...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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