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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://www.readbyqxmd.com/read/30102789/teriparatide-treatment-increases-mineral-content-and-volume-in-cortical-and-trabecular-bone-of-iliac-crest-a-comparison-of-infrared-imaging-with-x-ray-based-bone-assessment-techniques
#1
Paschalis Ep, Krege Jh, Gamsjaeger S, Eriksen Ef, Burr Db, Disch Dp, Stepan Jj, Fahrleitner-Pammer A, Klaushofer K, Marin F, Pavo I
Teriparatide increases bone mass primarily through remodeling of older or damaged bone and abundant replacement with new mineralizing bone. This post-hoc analysis investigated whether dual energy X-ray absorptiometric (DXA) areal bone mineral density (aBMD) measurement adequately reflects changes of mineral and organic matrix content in cortical and trabecular bone. Paired biopsies and aBMD measurements were obtained before and at end of 2-years of teriparatide treatment from postmenopausal women with osteoporosis who were either alendronate pre-treated (mean of 57...
August 13, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30102788/to-the-editor
#2
LETTER
Paul D Miller, John P Bilezikian, E Michael Lewiecki, Nelson B Watts, John J Carey
To The Editor We were pleased to read and are delighted to acknowledge the Editorial of Cummings and Eastell1 that reviewed the history of pivotal advances in clinical research into bone and mineral disease in connection with the 40th anniversary celebration of the ASBMR. The article provides a succinct review of several key epidemiological, technological, biochemical and therapeutic advances that, overall, have signalled landmark achievements in our field.
August 13, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30088288/effect-of-exercise-modality-during-weight-loss-on-bone-health-in-older-adults-with-obesity-and-cardiovascular-disease-or-metabolic-syndrome-a-randomized-controlled-trial
#3
Kristen M Beavers, Michael P Walkup, Ashley A Weaver, Leon Lenchik, Stephen B Kritchevsky, Barbara J Nicklas, Walter T Ambrosius, Joel D Stitzel, Thomas C Register, Sue A Shapses, Anthony P Marsh, W Jack Rejeski
The objective of this study was to determine the ability of either aerobic or resistance training to counter weight-loss-associated bone loss in older adults. There were 187 older adults (67 years, 70% women, 64% white) with obesity (BMI = 34.5 ± 3.7 kg/m2 ) and cardiovascular disease and/or metabolic syndrome who were randomized to participate in an 18-month, community-based trial, with a follow-up assessment at 30 months. Intervention arms included: weight loss alone (WL; 7% to 10% baseline weight), WL plus aerobic training (WL + AT), and WL plus resistance training (WL + RT), as well as DXA-acquired total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD), and trabecular bone score (TBS)...
August 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30075061/the-spectrum-of-fundamental-basic-science-discoveries-contributing-to-organismal-aging
#4
REVIEW
Joshua N Farr, Maria Almeida
Aging research has undergone unprecedented advances at an accelerating rate in recent years, leading to excitement in the field as well as opportunities for imagination and innovation. Novel insights indicate that, rather than resulting from a pre-programmed series of events, the aging process is predominantly driven by fundamental non-adaptive mechanisms that are interconnected, linked, and overlap. To varying degrees, these mechanisms also manifest with aging in bone where they cause skeletal fragility. Because these mechanisms of aging can be manipulated, it might be possible to slow, delay, or alleviate multiple age-related diseases and their complications by targeting conserved genetic signaling pathways, controlled functional networks, and basic biochemical processes...
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30075054/chronic-kidney-disease-is-associated-with-greater-bone-marrow-adiposity
#5
Gina N Woods, Susan K Ewing, Sigurdur Sigurdsson, Deborah M Kado, Joachim H Ix, Trisha F Hue, Gudny Eiriksdottir, Kaipin Xu, Vilmundur Gudnason, Thomas J Lang, Eric Vittinghoff, Tamara B Harris, Clifford J Rosen, Xiaojuan Li, Ann V Schwartz
Bone marrow adiposity is associated with aging, osteoporosis and reduced hematopoiesis as well as anorexia nervosa but little is known about the underlying mechanisms that affect marrow adiposity. Chronic kidney disease (CKD) may influence bone marrow adipose tissue (BMAT), possibly through loss of lean mass or higher circulating levels of sclerostin. To test these hypotheses, we investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) as a measure of kidney function and 1 H-MRS based measurement of vertebral BMAT (L1-L4) in 475 older adults from the AGES-Reykjavik study...
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30075050/serotonin-a-new-potential-risk-factor-for-falls-low-bmd-and-fracture
#6
Peter Vestergaard
Serotonin is a neurotransmitter present in the central nervous system (CNS) and intestine. It binds to the 5-HT (hydroxytryptamine)-receptor, and regulates gastrointestinal (GI) movements, CNS signaling resulting in changes in mood and memory as well as cardiovascular effects, including vasoconstriction and blood flow. The 5-HT receptors are mainly G-protein coupled receptors that may mediate excitatory and inhibitory signaling. This article is protected by copyright. All rights reserved.
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30075049/the-lysosomal-protein-arylsulfatase-b-is-a-key-enzyme-involved-in-skeletal-turnover
#7
Sandra Pohl, Alexandra Angermann, Anke Jeschke, Gretl Hendrickx, Timur A Yorgan, Georgia Makrypidi-Fraune, Anita Steigert, Sonja C Kuehn, Tim Rolvien, Michaela Schweizer, Till Koehne, Mona Neven, Olga Winter, Renata Voltolini Velho, Joachim Albers, Thomas Streichert, Jan M Pestka, Christina Baldauf, Sandra Breyer, Ralf Stuecker, Nicole Muschol, Timothy M Cox, Paul Saftig, Chiara Paganini, Antonio Rossi, Michael Amling, Thomas Braulke, Thorsten Schinke
Skeletal pathologies are frequently observed in lysosomal storage disorders, yet the relevance of specific lysosomal enzymes in bone remodeling cell types is poorly defined. Two lysosomal enzymes, i.e. Ctsk (cathepsin K) and Acp5 (also known as tartrate-resistant acid phosphatase), are long known as molecular marker proteins of differentiated osteoclasts. However, whereas the cysteine protease Ctsk is directly involved in the degradation of bone matrix proteins, the molecular function of Acp5 in osteoclasts is still unknown...
August 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30048570/relating-intracortical-bone-mechanics-to-pore-morphology-and-remodeling-characteristics-in-the-human-fibula
#8
Lydia P Bakalova, Christina M Andreasen, Jesper Skovhus Thomsen, Annemarie Brüel, Ellen-Margrethe Hauge, Birgitte Jul Kiil, Jean-Marie Delaisse, Thomas Levin Andersen, Mariana E Kersh PhD
During aging and in osteoporosis, cortical bone becomes more porous, making it more fragile and susceptible to fractures. The aim of this study was to investigate the intracortical compression- induced strain energy distribution, and determine whether intracortical pores associated with high strain energy density (SED) in the surrounding bone matrix have a different morphology, distribution and remodeling characteristics than matrix with normal SED. Fibular diaphyseal specimens from 20 patients undergoing a jaw reconstruction (age range 41-75 years, 14 men and 6 women) were studied...
July 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30088838/comparative-effect-of-rhpth-1-84-on-bone-mineral-density-and-trabecular-bone-score-in-hypoparathyroidism-and-postmenopausal-osteoporosis
#9
Cristiana Cipriani, Jessica Pepe, Barbara C Silva, Mishaela R Rubin, Natalie E Cusano, Donald J McMahon, Luciano Nieddu, Maurizio Angelozzi, Federica Biamonte, Daniele Diacinti, Didier Hans, Salvatore Minisola, John P Bilezikian
Parathyroid hormone (PTH) (1-84) improves lumbar spine (LS) areal bone mineral density (aBMD) and trabecular bone score (TBS) in hypoparathyroidism over a 2-year treatment period. Studies in osteoporosis have shown that with PTH(1-34) there is a significant increase in LS aBMD and TBS. In this article, we provide new data comparing the effects of the same form of PTH, namely recombinant human PTH, rhPTH(1-84), on aBMD and TBS in hypoparathyroid and osteoporotic patients over an 18-month treatment period. We studied 19 premenopausal (mean age 45...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30040873/retinoic-acid-receptor-%C3%AE-activity-in-mesenchymal-stem-cells-regulates-endochondral-bone-angiogenesis-and-b-lymphopoiesis
#10
Alanna C Green, Victoria Rudolph-Stringer, Lenny Straszkowski, Gavin Tjin, Blessing Crimeen-Irwin, Mannu Walia, T John Martin, Natalie A Sims, Louise E Purton
Retinoic acid receptor (RAR) signaling regulates bone structure and hematopoiesis through intrinsic and extrinsic mechanisms. This study aimed to establish how early in the osteoblast lineage loss of RARγ (Rarg) disrupts the bone marrow microenvironment. Bone structure was analyzed by micro-computed tomography (μCT) in Rarg-/- mice and mice with Rarg conditional deletion in Osterix-Cre-targeted osteoblast progenitors or Prrx1-Cre-targeted mesenchymal stem cells. Rarg-/- tibias exhibited less trabecular and cortical bone and impaired longitudinal and radial growth...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30040148/structural-adaptations-in-the-rat-tibia-bone-induced-by-pregnancy-and-lactation-confer-protective-effects-against-future-estrogen-deficiency
#11
Chantal Mj de Bakker, Yihan Li, Hongbo Zhao, Laurel Leavitt, Wei-Ju Tseng, Tiao Lin, Wei Tong, Ling Qin, X Sherry Liu
The female skeleton undergoes substantial structural changes during the course of reproduction. Although bone mineral density recovers postweaning, reproduction may induce permanent alterations in maternal bone microarchitecture. However, epidemiological studies suggest that a history of pregnancy and/or lactation does not increase the risk of postmenopausal osteoporosis or fracture and may even have a protective effect. Our study aimed to explain this paradox by using a rat model, combined with in vivo micro-computed tomography (μCT) imaging and bone histomorphometry, to track the changes in bone structure and cellular activities in response to estrogen deficiency following ovariectomy (OVX) in rats with and without a reproductive history...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30040140/comparing-strategies-targeting-osteoporosis-to-prevent-fractures-after-an-upper-extremity-fracture-c-stop-trial-a-randomized-controlled-trial
#12
Sumit R Majumdar, Finlay A McAlister, Jeffrey A Johnson, Brian H Rowe, Debbie Bellerose, Imran Hassan, Douglas A Lier, Stephanie Li, Walter P Maksymowych, Matthew Menon, Anthony S Russell, Brian Wirzba, Lauren A Beaupre
We compared osteoporosis care after upper extremity fragility fracture using a low-intensity Fracture Liaison Service (FLS) versus a high-intensity FLS in a pragmatic patient-level parallel-arm comparative effectiveness trial undertaken at a Canadian academic hospital. A low-intensity FLS (active-control) that 'identified' patients and notified primary care providers was compared to a high-intensity FLS (case manager) where a specially-trained nurse 'identified' patients, 'investigated' bone health and 'initiated' appropriate treatment...
July 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30011100/response-to-osteoporotic-vertebral-fracture-prevalence-varies-widely
#13
LETTER
Edwin Hg Oei, Fjorda Koromani, Fernando Rivadeneira, Ling Oei
No abstract text is available yet for this article.
July 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30011094/michael-kleerekoper-august-18-1944-to-may-10-2018-in-relentless-pursuit-of-a-better-way
#14
Michael Kleerekoper
No abstract text is available yet for this article.
July 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30011091/fracture-risk-after-gastric-bypass-surgery-a-retrospective-cohort-study
#15
Kristian F Axelsson, Malin Werling, Björn Eliasson, Eva Szabo, Ingmar Näslund, Hans Wedel, Dan Lundh, Mattias Lorentzon
Gastric bypass surgery constitutes the most common and effective bariatric surgery to treat obesity. Gastric bypass leads to bone loss, but fracture risk following surgery has been insufficiently studied. Furthermore, the association between gastric bypass and fracture risk has not been studied in patients with diabetes, which is a risk factor for fracture and affected by surgery. In this retrospective cohort study using Swedish national databases, 38 971 obese patients undergoing gastric bypass were identified, 7758 with diabetes and 31 213 without...
July 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30011086/measures-of-physical-performance-and-muscle-strength-as-predictors-of-fracture-risk-independent-of-frax-falls-and-bmd-a-meta-analysis-of-the-osteoporotic-fractures-in-men-mros-study
#16
Nicholas C Harvey, Anders Odén, Eric Orwoll, Jodi Lapidus, Timothy Kwok, Magnus K Karlsson, Björn E Rosengren, Eva Ribom, Cyrus Cooper, Peggy M Cawthon, John A Kanis, Claes Ohlsson, Dan Mellström, Helena Johansson, Eugene McCloskey
Measures of muscle mass, strength and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX® probability. We investigated, in the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, USA), whether measures of physical performance/ appendicular lean mass by DXA predicted incident fractures in older men, independently of FRAX probability. Baseline information included falls history, clinical risk factors for falls and fractures, femoral neck BMD, and calculated FRAX probabilities...
July 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30001469/serum-25-hydroxyvitamin-d-and-intact-parathyroid-hormone-influences-muscle-outcomes-in-children-and-adolescents
#17
Christian S Wright, Emma M Laing, Norman K Pollock, Dorothy B Hausman, Connie M Weaver, Berdine R Martin, George P McCabe, Munro Peacock, Stuart J Warden, Kathleen Hill Gallant, Richard D Lewis
Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled vitamin D intervention in US children and adolescents, we examined the associations between changes in vitamin D metabolites and changes in muscle mass, strength, and composition following 12-weeks of vitamin D3 supplementation. Healthy male and female, black and white children and adolescents between the ages of 9-13 years old from two US states (Georgia 34°N and Indiana 40°N) were enrolled in the study and randomly assigned to receive an oral vitamin D3 dose of 0, 400, 1,000, 2,000 or 4,000 IU/d for 12 weeks between the winter months of 2009 to 2011 (N = 324)...
July 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30001467/phosphorylation-of-extracellular-bone-matrix-proteins-and-its-contribution-to-bone-fragility
#18
Grażyna E Sroga, Deepak Vashishth
Phosphorylation of bone matrix proteins is of fundamental importance to all vertebrates including humans. However, it is currently unknown whether increase or decline of total protein phosphorylation levels, particularly in hypophosphatemia-related osteoporosis, osteomalacia and rickets contributes to bone fracture. To address this gap, we combined biochemical measurements with mechanical evaluation of bone to discern fracture characteristics associated with age-related development of skeletal fragility in relation to total phosphorylation levels of bone matrix proteins and one of the key representatives of bone matrix phosphoproteins, osteopontin (OPN)...
July 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30001459/sexual-dimorphism-in-cortical-and-trabecular-bone-microstructure-appears-during-puberty-in-chinese-children
#19
Ka Yee Cheuk, Xiao-Fang Wang, Ji Wang, Zhendong Zhang, Fiona Wai Ping Yu, Elisa Man Shan Tam, Vivian Wing Yin Hung, Wayne Yuk Wai Lee, Ali Ghasem-Zadeh, Roger Zebaze, Tracy Y Zhu, X Edward Guo, Jack Chun Yiu Cheng, Tsz Ping Lam, Ego Seeman
Distal forearm fractures during growth are more common in males than females. Because metaphyseal cortical bone is formed by coalescence of trabeculae emerging from the periphery of the growth plate, we hypothesized that the later onset of puberty in males produces a longer delay in trabecular bone formation and coalescence, which leaves a transient phase of high cortical porosity, low matrix mineral density, and high trabecular density relative to females. We quantified the nondominant distal radial microstructure using high-resolution peripheral quantitative computed tomography in 214 healthy Chinese boys and 219 Chinese girls aged between 7 and 17 years living in Hong Kong...
July 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30001457/diminished-canonical-%C3%AE-catenin-signaling-during-osteoblast-differentiation-contributes-to-osteopenia-in-progeria
#20
Ji Young Choi, Jim K Lai, Zheng-Mei Xiong, Margaret Ren, Megan C Moorer, Joseph P Stains, Kan Cao
Patients with Hutchinson-Gilford progeria syndrome (HGPS) have low bone mass and an atypical skeletal geometry that manifests in a high risk of fractures. Using both in vitro and in vivo models of HGPS, we demonstrate that defects in the canonical WNT/β-catenin pathway, seemingly at the level of the efficiency of nuclear import of β-catenin, impair osteoblast differentiation and that restoring β-catenin activity rescues osteoblast differentiation and significantly improves bone mass. Specifically, we show that HGPS patient-derived iPSCs display defects in osteoblast differentiation, characterized by a decreased alkaline phosphatase activity and mineralizing capacity...
July 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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