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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://www.readbyqxmd.com/read/29232486/an-essential-warning-editorial-on-vertebral-fractures-after-discontinuation-of-denosumab-a-post-hoc-analysis-of-the-randomized-placebo-controlled-freedom-trial-its-extension
#1
Benjamin Leder
Over the past two decades, osteoporosis treatment options have expanded greatly and physicians and patients are now able to choose among several classes of medications and numerous specific drugs. As these options have grown, however, the choice of which medication to prescribe and how to balance the risks and benefits in specific populations and individual patients has become increasingly complex. This complexity, in turn, combined with the proliferation of well-publicized reports of rare but serious side effects, is exacerbating the recent trend of declining rates of osteoporosis treatment...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29232481/tracking-of-areal-bone-mineral-density-from-age-eight-to-young-adulthood-and-factors-associated-with-deviation-from-tracking-a-17-yr-prospective-cohort-study
#2
Yi Yang, Feitong Wu, Tania Winzenberg, Graeme Jones
We have previously shown that bone mineral density (BMD) tracks strongly from age 8 to 16. This study aimed to describe whether this strong tracking continued to age 25 and describe factors associated with deviation from tracking. Ninety-nine participants were followed from age 8 to 25 and 197 participants from age 16 to 25. Outcomes measured were BMD at the spine, hip and total body (by dual-energy X-ray absorptiometry (DXA)). Other factors measured were anthropometrics, inhaled corticosteroids (ICS) use, history of being breastfed, sports participation, fitness (by physical work capacity (PWC170 )), lean mass (LM) and fat mass (FM) (by DXA)...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29232479/metabolomic-pathways-to-osteoporosis-in-middle-aged-women-a-genome-metabolome-wide-mendelian-randomization-study
#3
Alireza Moayyeri, Ching-Lung Cheung, Kathryn Cb Tan, John A Morris, Agustin Cerani, Robert P Mohney, J Brent Richard, Christopher Hammond, Tim D Spector, Cristina Menni
The metabolic state of the body can be a major determinant of bone health. We used a Mendelian Randomization approach to identify metabolites causally associated with bone mass to better understand the biological mechanisms of osteoporosis. We tested bone phenotypes (femoral neck, total hip, and lumbar spine BMD) for association with 280 fasting blood metabolites in 6055 women from TwinsUK cohort with genome-wide genotyping scans. Causal associations between metabolites and bone phenotypes were further assessed in a bidirectional Mendelian Randomization study using genetic markers/scores as instrumental variables...
December 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29220072/falls-predict-fractures-independently-of-frax-probability-a-meta-analysis-of-the-osteoporotic-fractures-in-men-mros-study
#4
Nicholas C Harvey, Anders Odén, Eric Orwoll, Jodi Lapidus, Timothy Kwok, Magnus K Karlsson, Björn E Rosengren, Östen Ljunggren, Cyrus Cooper, Eugene McCloskey, John A Kanis, Claes Ohlsson, Dan Mellström, Helena Johansson
Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted future fracture independently of FRAX and whether these associations varied with age and follow-up time. Elderly men were recruited from MrOS Sweden, Hong Kong, and USA...
December 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29218771/menopause-related-appendicular-bone-loss-is-mainly-cortical-and-results-in-increased-cortical-porosity
#5
Åshild Bjørnerem, Xiaofang Wang, Minh Bui, Ali Ghasem-Zadeh, John L Hopper, Roger Zebaze, Ego Seeman
After menopause, remodeling becomes unbalanced and rapid. Each of the many remodeling transactions deposits less bone than it resorbed, producing microstructural deterioration. Trabecular bone is said to be lost more rapidly than cortical bone. However, because 80% of the skeleton is cortical, we hypothesized that most menopause-related bone loss and changes in bone microstructure are cortical, not trabecular in origin, and are the result of intracortical remodeling. Distal tibial and distal radial microstructure were quantified during 3...
December 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29206332/inactivation-of-mtorc1-signaling-in-osterix-expressing-cells-impairs-b-cell-differentiation
#6
Yongkui Wang, Min Xiao, Chen Tao, Jing Chen, Zhenyu Wang, Jun Yang, Zhenguo Chen, Zhipeng Zou, Anling Liu, Daozhang Cai, Yu Jiang, Changhai Ding, Mangmang Li, Xiaochun Bai
Osteoblasts provide a microenvironmental niche for B-cell commitment and maturation in the bone marrow (BM). Any abnormity of osteoblasts function may result in the defect of B lymphopoiesis. Signaling from mechanistic target of rapamycin complex 1 (mTORC1) has been implicated in regulating the expansion and differentiation of osteoblasts. Thus, we raise a hypothesis that mTORC1 signaling in osteoblasts plays a vital role in B-cell development. Inactivation of mTORC1 in osterix-expressing cells (mainly osteoblast lineage) through Osx-Cre-directed deletion of Raptor (an mTORC1-specific component) resulted in a reduction in the total B-cell population in the BM, which was due to a block in early B-cell development from the pro-B to pre-B cell stage...
December 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29206311/the-expanding-life-and-functions-of-osteogenic-cells-from-simple-bone-making-cells-to-multifunctional-cells-and-beyond
#7
REVIEW
Pierre J Marie, Martine Cohen-Solal
During the last three decades, important progresses in bone cell biology and in human and mouse genetics led to major advances in our understanding of the life and functions of cells of the osteoblast lineage. Previously unrecognized sources of osteogenic cells have been identified. Novel cellular and molecular mechanisms controlling osteoblast differentiation and senescence have been determined. New mechanisms of communications between osteogenic cells, osteocytes, osteoclasts and chondrocytes, as well as novel links between osteogenic cells and blood vessels have been identified...
December 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29206307/osteoprotection-through-the-deletion-of-the-transcription-factor-ror%C3%AE-in-mice
#8
Joshua N Farr, Megan M Weivoda, Kristy M Nicks, Daniel G Fraser, Brittany A Negley, Jennifer L Onken, Brianne S Thicke, Ming Ruan, Hong Liu, Douglas Forrest, John R Hawse, Sundeep Khosla, David G Monroe
There is a clinical need to identify new molecular targets for the treatment of osteoporosis, particularly those that simultaneously inhibit bone resorption while stimulating bone formation. We have previously shown in overexpression studies that retinoic acid receptor-related orphan receptor β (Rorβ) suppresses in vitro osteoblast differentiation. In addition, the expression of Rorβ is markedly increased in bone marrow-derived mesenchymal stromal cells with aging in both mice and humans. Here we establish a critical role for Rorβ in regulating bone metabolism using a combination of in vitro and in vivo studies...
December 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29194768/jeffrey-lima-hayes-o-riordan-march-27-1931-october-9-2017
#9
Jeffrey Lima Hayes O'Riordan
No abstract text is available yet for this article.
November 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29194751/reply-to-levesque-et-al-macrophages-driving-heterotopic-ossification-convergence-of-genetically-driven-and-trauma-driven-mechanisms
#10
LETTER
Michael R Convente, Salin A Chakkalakal, EnJun Yang, Robert J Caron, Deyu Zhang, Taku Kambayashi, Frederick S Kaplan, Eileen M Shore
We appreciate the comments by Levesque and colleagues and that they have brought attention to the consistencies between our data using the genetic Acvr1R206H/+ mouse model of heterotopic ossification and their model of HO formation in wild-type mice with spinal cord injury-induced neurogenic heterotopic ossification (Genet et al.(1) and Torossian et al.(2) ). We agree that together these studies provide strong support for cytokine production by macrophages as a common inducer of HO.
November 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29194750/how-basic-science-discoveries-have-shaped-the-treatment-of-bone-and-mineral-disorders
#11
EDITORIAL
Bente L Langdahl, Stuart H Ralston
No abstract text is available yet for this article.
November 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29194749/longitudinal-effects-of-teriparatide-or-zoledronic-acid-on-bone-modeling-and-remodeling-based-formation-in-the-shotz-study
#12
David W Dempster, Hua Zhou, Valerie A Ruff, Thomas E Melby, Jahangir Alam, Kathleen A Taylor
Previously we reported on bone histomorphometry, biochemical markers, and bone mineral density distribution following 6 and 24 months of treatment with teriparatide (TPTD) or zoledronic acid (ZOL) in the SHOTZ study. The study included a 12-month primary study period, with treatment (TPTD 20 μg/day by subcutaneous injection or ZOL 5 mg/year by intravenous infusion) randomized and double-blind until the month 6 biopsy (TPTD n=28, ZOL n=30 evaluable), then open-label, with an optional 12-month extension receiving the original treatment...
November 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29193312/understanding-age-induced-cortical-porosity-in-women-the-accumulation-and-coalescence-of-eroded-cavities-upon-existing-intracortical-canals-is-the-main-contributor
#13
Christina Møller Andreasen, Jean-Marie Delaisse, Bram C J van der Eerden, Johannes P T M van Leeuwen, Ming Ding, Thomas Levin Andersen
Intracortical bone remodeling normally ensures maintenance of the cortical bone matrix and strength, but during aging, this remodeling generates excessive porosity. The mechanism behind the age-induced cortical porosity is poorly understood and addressed in the present study. This study consists of a histomorphometric analysis of sections of iliac bone specimens from 35 women (age 16-78 years). Firstly, the study shows that the aging-induced cortical porosity reflects an increased pore size rather than an increased pore density...
November 29, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29178621/macrophages-driving-heterotopic-ossification-convergence-of-genetically-driven-and-trauma-driven-mechanisms
#14
LETTER
Jean-Pierre Levesque, Natalie A Sims, Allison R Pettit, Kylie A Alexander, Hsu-Wen Tseng, Frédéric Torossian, François Genêt, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès
We read with great interest the recent article in the Journal of Bone and Mineral Research by Convente and colleagues "Depletion of mast cells and macrophage impairs heterotopic ossification in an Acvr1R206H mouse model of fibrodysplasia ossificans progressiva".(1) This paper reports that muscle injury caused by intramuscular injection of cardiotoxin from Naja mossambica mossambica venom into the Acvr1R206H mouse causes the development of heterotopic ossifications (HO) at the injury site. They demonstrated exacerbated macrophage and mast cell accumulation in Acvr1R206H mice and showed that depletion of macrophages in vivo with clodronate-loaded liposomes, genetic impairment of mast cells, or a combination of both approaches, substantially reduced the volume of HO...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29178513/relationship-between-neonatal-vitamin-d-at-birth-and-risk-of-autism-spectrum-disorders-the-nbsib-study
#15
Dong-Mei Wu, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Ya-Xing Bao, Jing Yan, Jun Lu, Yuan-Lin Zheng
Previous studies suggested that lower vitamin D might be a risk factor for autism spectrum disorders (ASDs). The aim of this study was to estimate the prevalence of ASDs in 3-year-old Chinese children and to examine the association between neonatal vitamin D status and risk of ASDs. We conducted a study of live births who had taken part in expanded newborn screening (NBS), with outpatient follow-up when the children 3-year old. The children were confirmed for ASDs in outpatient by the Autism Diagnostic Interview-Revised and Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29178458/impairment-of-bone-remodeling-in-light-tnfsf14-deficient-mice
#16
Giacomina Brunetti, Maria Felicia Faienza, Graziana Colaianni, Isabella Gigante, Angela Oranger, Paolo Pignataro, Giuseppe Ingravallo, Adriana Di Benedetto, Sara Bortolotti, Mariasevera Di Comite, Giuseppina Storlino, Luciana Lippo, Lindsay Ward-Kavanagh, Giorgio Mori, Janne E Reseland, Giovanni Passeri, Ernestina Schipani, Koji Tamada, Carl F Ware, Silvia Colucci, Maria Grano
Multiple cytokines produced by immune cells induce remodeling and aid in maintaining bone homeostasis through differentiation of bone forming osteoblasts and bone resorbing osteoclasts. Here, we investigate bone remodeling controlled by the TNF superfamily cytokine LIGHT. LIGHT-deficient mice (Tnfsf14-/- ) exhibit spine deformity, and reduced femoral cancellous bone mass associated with an increase in the osteoclast number and a slight decrease of osteoblasts compared to WT mice. The effect of LIGHT in bone cells can be direct or indirect, mediated by both the low expression of the anti-osteoclastogenic osteoprotegerin (OPG) in B and T cells, and reduced levels of the pro-osteoblastogenic Wnt10b in CD8+ T cells in Tnfsf14-/- ...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29178448/expanding-the-clinical-spectrum-of-phenotypes-caused-by-pathogenic-variants-in-plod2
#17
Gabriela Ferraz Leal, Gen Nishimura, Ulrika Voss, Débora Romeo Bertola, Eva Åström, Johan Svensson, Guilherme Lopes Yamamoto, Anna Hammarsjö, Eva Horemuzova, Nikos Papadiogannakis, Erik Iwarsson, Giedre Grigelioniene, Emma Tham
Osteogenesis imperfecta (OI) is a strikingly heterogeneous group of disorders with a broad range of phenotypic variations. It is also one of the differential diagnoses in bent bone dysplasias along with campomelic dysplasia and thanatophoric dysplasia and can usually be distinguished by decreased bone mineralization and bone fractures. Bent bone dyplasias also include syndromes such as kyphomelic dysplasia [MIM:211350] and mesomelic dysplasia Kozlowski-Reardon [MIM249710], both of which have been under debate regarding whether or not they are a real entity or simply a phenotypic manifestation of another dysplasia including OI...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29165841/in-memoriam-2017
#18
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29165840/how-important-is-vitamin-d-for-calcium-homeostasis-during-pregnancy-and-lactation
#19
Geert Carmeliet, Roger Bouillon
No abstract text is available yet for this article.
November 22, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29160916/changing-of-the-guard
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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