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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://www.readbyqxmd.com/read/29447437/j-shaped-association-between-post-operative-levothyroxine-dosage-and-fracture-risk-in-thyroid-cancer-patients-a-retrospective-cohort-study
#1
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Youngmin Park
Long-term administration of supraphysiologic dosages of levothyroxine can have detrimental effect on the bone. We aimed to investigate fracture incidence among post-thyroidectomy thyroid cancer patients compared with matched comparison group, and explore the association between levothyroxine dosage and fracture risk. From the Korean National Health Insurance database, virtually all thyroid cancer patients who received thyroidectomy in Korea from January 1, 2004 to December 31, 2012 were included. Matched subjects were selected by 1:1 propensity score matching...
February 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29444358/a-complex-role-for-lipocalin-2-in-bone-metabolism-global-ablation-in-mice-induces-osteopenia-caused-by-an-altered-energy-metabolism
#2
Mattia Capulli, Marco Ponzetti, Antonio Maurizi, Sara Gemini-Piperni, Thorsten Berger, Tak Wah Mak, Anna Teti, Nadia Rucci
Lipocalin 2 (Lcn2) is an adipokine that carries out a variety of functions in diverse organs. We investigated the bone phenotype and the energy metabolism of Lcn2 globally deleted mice (Lcn2 -/- ) at different ages. Lcn2 -/- mice were largely osteopenic, exhibiting lower trabecular bone volume, lesser trabecular number and higher trabecular separation when compared to wild type (WT) mice. Lcn2 -/- mice showed a lower osteoblast number and surface over bone surface, and subsequently a significantly lower bone formation rate, while osteoclast variables were unremarkable...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29444341/high-fat-diet-induced-obesity-promotes-expansion-of-bone-marrow-adipose-tissue-and-impairs-skeletal-stem-cell-functions-in-mice
#3
Michaela Tencerova, Florence Figeac, Nicholas Ditzel, Hanna Taipaleenmäki, Tina Kamilla Nielsen, Moustapha Kassem
Obesity represents a risk factor for development of insulin resistance and Type 2 Diabetes. In addition, it has been associated with increased adipocyte formation in the bone marrow (BM) along with increased risk for bone fragility fractures. However, little is known on the cellular mechanisms that link obesity, BM adiposity and bone fragility. Thus, in an obesity intervention study in C57BL/6J mice fed with high fat diet (HFD) for 12 weeks, we investigated the molecular and cellular phenotype of bone marrow adipose tissue (BMAT), BM progenitor cells and BM microenvironment in comparison to peripheral adipose tissue (AT)...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29443425/long-term-atherosclerotic-vascular-disease-risk-and-prognosis-in-elderly-women-with-abdominal-aortic-calcification-on-lateral-spine-images-captured-during-bone-density-testing-a-prospective-study
#4
Joshua R Lewis, John T Schousboe, Wai H Lim, Germaine Wong, Kevin E Wilson, Kun Zhu, Peter L Thompson, Douglas P Kiel, Richard L Prince
Lateral spine images are captured using bone densitometers for vertebral fracture assessment (VFA) in older women. Abdominal aortic calcification (AAC) is commonly seen on these images however the long-term prognosis in women with AAC remains uncertain. In a prospective study of 1,052 community-dwelling ambulant Caucasian women over 70 years AAC24 scores were calculated from digital lateral spine images captured during bone density testing in 1998 or 1999. Cardiovascular risk factors were assessed in 1998 while 14...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29419889/response-to-dr-lamy-and-dr-gonzalez-rodriguez
#5
LETTER
Steven R Cummings, Serge Ferrari, Jacques P Brown, Andrea T Wang
Dr. Lamy and Dr. Gonzalez-Rodriguez note that our analysis of risk of vertebral fractures after stopping denosumab, based on 0.2 to 0.5 years of median follow-up, may underestimate the risk of vertebral fractures during longer periods of follow-up.
February 8, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29419882/vertebral-fracture-diagnostic-difficulties-of-a-major-medical-problem
#6
Pawel Szulc
Vertebral fracture - difficult diagnostics of the major medical problem. This article is protected by copyright. All rights reserved.
February 8, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29405385/specificity-protein-7-is-required-for-proliferation-and-differentiation-of-ameloblasts-and-odontoblasts
#7
Ji-Myung Bae, John C Clarke, Harunur Rashid, Mitra D Adhami, Kayla McCullough, Jordan S Scott, Haiyan Chen, Krishna M Sinha, Benoit de Crombrugghe, Amjad Javed
The Sp7/Osterix transcription factor is essential for bone development. Mutations of Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta. However, the role of Sp7 in embryonic tooth development remains unknown. Here we identified the functional requirement of Sp7 for dentin synthesis and tooth development. Sp7-null mice exhibit craniofacial dysmorphogenesis and are completely void of alveolar bone. Surprisingly, initial tooth morphogenesis progressed normally in Sp7-null mice...
February 5, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29405383/the-quest-for-osteoporosis-mechanisms-and-rational-therapies-how-far-we-ve-come-how-much-further-we-need-to-go
#8
Stavros C Manolagas
During the last 40 years, understanding of bone biology and the pathogenesis of osteoporosis, the most common and impactful bone disease of old age, has improved dramatically thanks to basic and clinical research advances, genetic insights from humans and rodents, and newer imaging technologies. Culprits of osteoporosis are no longer a matter of speculation based on in vitro observations. Instead, they can be identified and dissected at the cellular and molecular level using genetic approaches; and their effect on distinct bone envelopes and anatomic regions can be functionally assessed in vivo...
February 5, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29405377/a-bigger-bone-and-mineral-umbrella-jbmr-and-jbmr-plus-embrace-preprints
#9
EDITORIAL
Erin Bove-Fenderson, Katie Duffy, Michael Mannstadt
No abstract text is available yet for this article.
February 5, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29394462/sex-ethnic-and-age-specific-centile-curves-for-pqct-and-hr-pqct-derived-measures-of-bone-structure-and-strength-in-adolescents-and-young-adults
#10
Leigh Gabel, Lindsay A Nettlefold, Heather M Macdonald, Heather A McKay
There are presently no adolescent centile curves for bone parameters at the tibial midshaft using peripheral quantitative computed tomography (pQCT) or at the distal radius and tibia using high-resolution pQCT (HR-pQCT). Thus, we aimed to develop sex-, ethnic-, site- and age-specific centile curves for pQCT and HR-pQCT-derived bone outcomes for youth and young adults aged 10-21 years. We acquired pQCT scans (XCT3000) at the tibial midshaft (50% site) and HR-pQCT scans (XtremeCT, Scanco Medical) at the distal radius (7% site) and tibia (8% site) in a convenience sample of participants in the mixed-longitudinal University of British Columbia Healthy Bones III Study...
February 2, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29393984/underestimation-of-vertebral-fractures-after-denosumab-discontinuation
#11
LETTER
Olivier Lamy, Elena Gonzalez-Rodriguez
We have read with interest the article on vertebral fractures after stopping Denosumab by Cummings SR et al. (1). Denosumab discontinuation is followed by a rebound effect with an increase of CTX above baseline values for two years and a decrease of BMD to baseline value after one year (2). Spontaneous clinical vertebral fractures, most often multiple, occur in the 8 to 16 months (median 11.2 months) following the last Denosumab injection (3). The risk of clinical vertebral fractures in the 12 months following the last Denosumab injection was evaluated at 7...
February 2, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29377379/sphk1-s1pr1-rankl-axis-regulates-the-interactions-between-macrophages-and-bmscs-in-inflammatory-bone-loss
#12
Lan Xiao, Yinghong Zhou, Lingxin Zhu, Shasha Yang, Rong Huang, Wei Shi, Bin Peng, Yin Xiao
Accumulating evidence indicates that the immune and skeletal systems interact with each other through various regulators during the osteoclastogenic process. Among these regulators, the bioactive lipid sphingosine-1-phosphate (S1P), which is synthesized by sphingosine kinase 1/2 (SPHK1/2), has recently been recognized to play a role in immunity and bone remodeling through its receptor sphingosine-1-phosphate receptor 1 (S1PR1). However, little is known regarding the potential role of S1PR1 signaling in inflammatory bone loss...
January 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29377378/evaluation-of-a-multi-modal-direct-to-patient-educational-intervention-targeting-barriers-to-osteoporosis-a-randomized-clinical-trial
#13
Maria I Danila, Ryan C Outman, Elizabeth J Rahn, Amy S Mudano, David T Redden, Peng Li, Jeroan J Allison, Fred A Anderson, Allison Wyman, Susan L Greenspan, Andrea Z LaCroix, Jeri W Nieves, Stuart L Silverman, Ethel S Siris, Nelson B Watts, Michael J Miller, Jeffrey R Curtis, Amy H Warriner, Nicole C Wright, Kenneth G Saag
Osteoporosis treatment rates are declining, even among those with past fractures. Novel, low-cost approaches are needed to improve osteoporosis care. We conducted a parallel group, controlled, randomized clinical trial evaluating a behavioral intervention for improving osteoporosis medication use. A total of 2,684 women with self-reported fracture history after age 45 not using osteoporosis therapy from U.S. Global Longitudinal study of Osteoporosis in Women (GLOW) sites were randomized 1:1 to receive a multi-modal, tailored, direct-to-patient, video intervention vs...
January 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29377313/sost-sclerostin-improves-post-traumatic-osteoarthritis-and-inhibits-mmp2-3-expression-after-injury
#14
Jiun C Chang, Blaine A Christiansen, Deepa K Murugesh, Aimy Sebastian, Nicholas R Hum, Nicole M Collette, Sarah Hatsell, Aris N Economides, Craig D Blanchette, Gabriela G Loots
Patients with anterior cruciate ligament (ACL) rupture are 2X as likely to develop post traumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the US, which account for ∼12% of all OA cases. PTOA leads to reduced physical activity, deconditioning of the musculoskeletal system and in severe cases, requires joint replacement to restore function. Therefore, treatments that would prevent cartilage degradation post injury would provide attractive alternatives to surgery. Sclerostin (Sost), a Wnt antagonist and a potent negative regulator of bone formation has recently been implicated in regulating chondrocyte function in osteoarthritis (OA)...
January 26, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29363165/lower-bone-density-impaired-microarchitecture-and-strength-predict-future-fragility-fracture-in-postmenopausal-women-5-year-follow-up-of-the-calgary-camos-cohort
#15
Lauren A Burt, Sarah L Manske, David A Hanley, Steven K Boyd
The aim of this prospective study was to use high-resolution peripheral quantitative computed tomography (HR-pQCT) to determine if baseline skeletal parameters can predict incident fragility fracture in women and, secondly, to establish if women that fracture lose bone at a faster rate than those who do not fracture. Women older than 60 years who experienced a fragility fracture during the 5-year follow-up period (incident fracture group, n = 22) were compared with those who did not experience a fragility fracture during the study (n = 127)...
January 24, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29351359/cyr61-ccn1-regulates-sclerostin-levels-and-bone-maintenance
#16
Gexin Zhao, Bau-Lin Huang, Diana Rigueur, Weiguang Wang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, Jie Jiang, Karen M Lyons
CYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and osteogenic differentiation in vitro. In this study we generated Cyr61 bone specific knockout mice to examine the physiological role of CYR61/CCN1 in bone development and maintenance in vivo. Extensive analysis of Cyr61 conditional knockout mice showed a significant decrease in both trabecular and cortical bone mass as compared to WT littermate...
January 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#17
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342320/association-of-pre-esrd-serum-calcium-with-post-esrd-mortality-among-incident-esrd-patients-a-cohort-study
#18
Yoshitsugu Obi, Christina Park, Melissa Soohoo, Keiichi Sumida, Takayuki Hamano, Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342317/osteoblast-like-mc3t3-e1-cells-prefer-glycolysis-for-atp-production-but-adipocyte-like-3t3-l1-cells-prefer-oxidative-phosphorylation
#19
Anyonya R Guntur, Akos A Gerencser, Phuong T Le, Victoria E DeMambro, Sheila A Bornstein, Shona A Mookerjee, David E Maridas, David E Clemmons, Martin D Brand, Clifford J Rosen
Mesenchymal stromal cells (MSCs) are early progenitors that can differentiate into osteoblasts, chondrocytes and adipocytes. We hypothesized that osteoblasts and adipocytes utilize distinct bioenergetic pathways during MSC differentiation. To test this hypothesis, we compared the bioenergetic profiles of pre-osteoblast MC3T3-E1 cells and calvarial osteoblasts with pre-adipocyte 3T3L1 cells, before and after differentiation. Differentiated MC3T3-E1 osteoblasts met ATP demand mainly by glycolysis with minimal reserve glycolytic capacity, whereas non-differentiated cells generated ATP through oxidative phosphorylation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29338102/circulating-serum-25-hydroxyvitamin-d-levels-and-bone-mineral-density-mendelian-randomization-study
#20
Susanna C Larsson, Håkan Melhus, Karl Michaëlsson
There is considerable discussion of the importance for increased serum 25-hydroxyvitamin D (S-25OHD) concentration associated with adequacy for bone health. Accordingly, whether long-term high S-25OHD concentration in general positively affects bone mineral density (BMD) is uncertain. We used a Mendelian randomization design to determine the association between genetically increased S-25OHD concentrations and BMD. Five single-nucleotide polymorphisms (SNPs) in or near genes encoding enzymes and carrier proteins involved in vitamin D synthesis or metabolism were used as instrumental variables to genetically predict one standard deviation increase in S-25OHD concentration...
January 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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