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Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research

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https://www.readbyqxmd.com/read/28436105/exercise-decreases-marrow-adipose-tissue-though-%C3%A3-oxidation-in-obese-running-mice
#1
Maya Styner, Gabriel M Pagnotti, Cody McGrath, Xin Wu, Buer Sen, Gunes Uzer, Zhihui Xie, Xiaopeng Zong, Martin A Styner, Clinton T Rubin, Janet Rubin
The relationship between marrow adipose tissue (MAT) and bone health is poorly understood. We used running exercise to ask whether obesity-associated-MAT can be attenuated via exercise and whether this correlates with gains in bone quantity and quality. C57BL/6 mice were divided into diet-induced obesity (DIO n = 14) vs. low-fat diet (LFD n = 14). After 3 months, 16-week-old mice were allocated to an exercise intervention (LFD-E, DIO-E) or a control group (LFD, DIO) for 6 week (4 groups, n = 7/group)...
April 24, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28430378/treating-paget-s-disease-why-and-how-much
#2
Tim Cundy
Paget's disease (PDB) is a benign chronic focal disorder of older people. Affected bones have greatly accelerated bone turnover, a chaotic structure and are highly vascular. People with PDB are commonly asymtomatic but can also suffer chronic bone pain. Affected bones may become enlarged and deformed; and they are also liable to fracture. This article is protected by copyright. All rights reserved.
April 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28425624/a-statistical-approach-to-fine-mapping-for-the-identification-of-potential-causal-variants-related-to-bone-mineral-density
#3
Jonathan Greenbaum, Hong-Wen Deng
Although GWAS have been able to successfully identify dozens of genetic loci associated with bone mineral density (BMD) and osteoporosis related traits, very few of these loci have been confirmed to be causal. This is due to the fact that in a given genetic region there may exist many trait-associated SNPs that are highly correlated. While this correlation is useful for discovering novel associations, the high degree of linkage disequilibrium that persists throughout the genome presents a major challenge to discern which among these correlated variants has a direct effect on the trait...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28425622/targeted-disruption-of-nf1-in-osteocyte-increases-fgf23-and-osteoid-with-osteomalacia-like-bone-phenotype
#4
Nobuhiro Kamiya, Ryosuke Yamaguchi, Olumide Aruwajoye, Audrey Kim, Gen Kuroyanagi, Matthew Phipps, Naga Suresh Adapala, Jian Q Feng, Harry K W Kim
Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi-system abnormalities including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the protein product of the NF1 gene, in osteocytes is largely unknown. This study investigated the role of neurofibromin in osteocytes by disrupting Nf1 under the Dmp1-promoter. The conditional knockout (Nf1 cKO) mice displayed serum profile of a metabolic bone disorder with an osteomalacia-like bone phenotype...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28425620/periarticular-bone-loss-in-arthritis-is-induced-by-autoantibodies-against-citrullinated-vimentin
#5
Cecilia Engdahl, Holger Bang, Katharina Dietel, Stefanie C Lang, Ulrike Harre, Georg Schett
Periarticular bone loss is a long known but yet insufficiently understood phenomenon in patients with rheumatoid arthritis. This study investigated whether autoimmunity against citrullinated proteins is causally involved in triggering periarticular bone loss. Periarticular bone loss was studied in the standard antigen induced arthritis (AIA) mouse model with methylated bovine serum albumin (mBSA) as well as modified model with mutated citrullinated vimentin (MCV) alone or in combination with mBSA. Periarticular bone loss, subchondral osteoclastogenesis as well as local expression of cytokines, osteoclast genes and PAD enzymes were assessed after arthritis induction...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28425581/clinical-biochemical-and-genetic-features-of-41-han-chinese-families-with-primary-hypertrophic-osteoarthropathy-and-their-therapeutic-response-to-etoricoxib-results-from-a-6-months-prospective-clinical-intervention
#6
Shan-Shan Li, Jin-We He, Wen-Zhen Fu, Yu-Juan Liu, Yun-Qiu Hu, Zhen-Lin Zhang
Primary hypertrophic osteoarthropathy (PHO) is a rare inherited disease caused by genetic defects in prostaglandin metabolism pathway; disturbed prostaglandin E2 (PGE2 ) catabolism resulting in increased PGE2 levels is suggested in the pathogenesis. Forty-three Han Chinese patients with PHO were studied and 41 of them were treated. Mutations in HPGD gene, causing hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1; OMIM 259100), were identified in 7 patients, and mutations in SLCO2A1 gene, causing hypertrophic osteoarthropathy, primary, autosomal recessive 2 (PHOAR2; OMIM 614441), were identified in 36 patients...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419547/perinatal-dna-methylation-at-cdkn2a-is-associated-with-offspring-bone-mass-findings-from-the-southampton-women-s-survey
#7
Elizabeth M Curtis, Robert Murray, Philip Titcombe, Eloïse Cook, Rebecca Clarke-Harris, Paula Costello, Emma Garratt, Joanna D Holbrook, Sheila Barton, Hazel Inskip, Keith M Godfrey, Christopher G Bell, Cyrus Cooper, Karen A Lillycrop, Nicholas C Harvey
Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship which may in part be mediated through altered epigenetic regulation of genes. We previously identified a region within the promoter of the long non-coding RNA ANRIL encoded by the CDKN2A locus, at which differential DNA methylation at birth showed correlations with offspring adiposity. Given the common lineage of adipocytes and osteoblasts, we investigated the relationship between perinatal CDKN2A methylation and bone mass at ages 4 and 6 years...
April 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419546/connexin43-and-runx2-interact-to-affect-cortical-bone-geometry-skeletal-development-and-osteoblast-and-osteoclast-function
#8
Atum M Buo, Ryan E Tomlinson, Eric R Eidelman, Max Chason, Joseph P Stains
The coupling of osteoblasts and osteocytes by connexin43 (Cx43) gap junctions permits the sharing of second messengers that coordinate bone cell function and cortical bone acquisition. However, details of how Cx43 converts shared second messengers into signals that converge onto essential osteogenic processes are incomplete. Here, we use in vitro and in vivo methods to show that Cx43 and Runx2 functionally interact to regulate osteoblast gene expression and proliferation, ultimately affecting cortical bone properties...
April 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28407309/cadmium-exposure-and-osteoporosis-a-population-based-study-and-benchmark-dose-estimation-in-southern-china
#9
Lv Yingjian, Wang Ping, Huang Rui, Liang Xuxia, Wang Peng, Tan Jianbin, Chen Zihui, Dun Zhongjun, Wang Jing, Jiang Qi, Wu Shixuan, Ling Haituan, Li Zhixue, Yang Xinfen
This study aimed to assess the association between osteoporosis and long-term environmental Cd exposure through diet in southern China. A total of 1116 subjects from a Cd-polluted area and a non-Cd-polluted area were investigated. All subjects met the criteria of having been living in the investigated area for more than 15 years and lived on a subsistence diet of rice and vegetables grown in that area. Besides bone mineral density, the levels of urinary markers of early renal impairment, such as urinary N-acetyl-β-D-glucosaminidase (NAG), α1 -microglobulin, β2 -microglobulin, and urinary albumin, were also determined...
April 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28407298/spatial-differences-in-the-distribution-of-bone-between-femoral-neck-and-trochanteric-fractures
#10
Aihong Yu, Julio Carballido-Gamio, Ling Wang, Thomas F Lang, Yongbin Su, Xinbao Wu, Manyi Wang, Jie Wei, Chen Yi, Xiaoguang Cheng
There is little knowledge about the spatial distribution differences in volumetric bone mineral density and cortical bone structure at the proximal femur between femoral neck fractures and trochanteric fractures. In this case-control study, a total of 93 women with fragility hip fractures, 72 with femoral neck fractures (mean ± SD age: 70.6 ± 12.7 years) and 21 with trochanteric fractures (75.6 ± 9.3 years), and 50 control subjects (63.7 ± 7.0 years) were included for the comparisons. Differences in the spatial distributions of volumetric bone mineral density, cortical bone thickness, cortical volumetric bone mineral density and volumetric bone mineral density in a layer adjacent to the endosteal surface were investigated using voxel-based morphometry (VBM) and surface-based statistical parametric mapping (SPM)...
April 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28394087/epigenome-wide-association-of-dna-methylation-in-whole-blood-with-bone-mineral-density
#11
John A Morris, Pei-Chien Tsai, Roby Joehanes, Jie Zheng, Katerina Trajanoska, Mette Soerensen, Vincenzo Forgetta, Juan Edgar Castillo-Fernandez, Morten Frost, Tim D Spector, Kaare Christensen, Lene Christiansen, Fernando Rivadeneira, Jonathan H Tobias, David M Evans, Douglas P Kiel, Yi-Hsiang Hsu, J Brent Richards, Jordana T Bell
Genetic and environmental determinants of skeletal phenotypes such as bone mineral density (BMD) may converge through the epigenome, providing a tool to better understand osteoporosis pathophysiology. As the epigenetics of BMD have been largely unexplored in humans, we performed an epigenome wide association study (EWAS) of BMD. We undertook a large-scale BMD EWAS using the Infinium HumanMethylation450 array to measure site-specific DNA methylation in up to 5,515 European descent individuals (NDiscovery  = 4,614, NValidation  = 901)...
April 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28394026/recurrent-hyperparathyroidism-due-to-a-novel-cdc73-splice-mutation
#12
Namita Ganesh Hattangady, Tremika Le-Shan Wilson, Barbra Sue Miller, Antonio Marcondes Lerario, Thomas James Giordano, Palak Choksi, Tobias Else
CONTEXT: The recognition of hereditary causes of primary hyperparathyroidism (pHPT) is important as clinical care and surveillance differ significantly between sporadic and hereditary pHPT. In addition, the increasing number of genetic tests poses a challenge to classify mutations as benign or pathogenic. Functional work-up of variants remains a mainstay to provide evidence for pathogenicity. CASE DESCRIPTION: We describe a 52-year old male patient with recurrent pHPT since age 35...
April 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370356/changes-in-bone-mineral-density-body-composition-vitamin-d-status-and-mineral-metabolism-in-urban-hiv-positive-south-african-women-over-12-months
#13
Matthew M Hamill, John M Pettifor, Kate A Ward, Shane A Norris, Ann Prentice
HIV infection and antiretroviral therapy (ART) are associated with bone loss and poor vitamin D status in Caucasian populations, though their relative roles are not known. No previous studies have examined longitudinal changes in areal bone mineral density (aBMD), measured by DXA, or in vitamin D status in HIV-positive African women. Of 247 premenopausal, urban, black African women from Soweto, South Africa, initially recruited, 187 underwent anthropometry, DXA scanning and blood and urine collections at both baseline and 12 months...
April 1, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370490/response-to-stoecker-et-al-%C3%A2
#14
LETTER
Sundeep Khosla, Elizabeth Shane
We would like to thank Drs. Stoecker and colleagues for their comments regarding our perspective. The first point raised by them relates to better patient education regarding the risks of fragility fractures and the need for new approaches to address this issue. We concur fully that this needs to be done and perhaps was not highlighted sufficiently in our perspective as we focused there more specifically on the atypical femur fracture (AFF) issue and ways to educate patients and physicians about the low risks of this adverse event versus the fracture risk reduction achieved by bisphosphonates...
March 31, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370465/pharmacologic-calcitriol-inhibits-osteoclast-lineage-commitment-via-the-bmp-smad1-i%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb-pathway
#15
Anna Li, Qian Cong, Xuechun Xia, Wai Fook Leong, James Yeh, Dengshun Miao, Yuji Mishina, Huijuan Liu, Baojie Li
Vitamin D is involved in a range of physiological processes and its active form and analogs have been used to treat diseases such as osteoporosis. Yet how vitamin D executes its function remains unsolved. Here we show that the active form of vitamin D calcitriol increases the peak bone mass in mice by inhibiting osteoclastogenesis and bone resorption. Although calcitriol modestly promoted osteoclast maturation, it strongly inhibited osteoclast lineage commitment from its progenitor monocyte by increasing Smad1 transcription via vitamin D receptor and enhancing BMP-Smad1 activation, which in turn led to increased IκBα expression and decreased NF-κB activation and NFATc1 expression, with IκBα being a Smad1 target gene...
March 31, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370446/addressing-the-crisis-in-the-treatment-of-osteoporosis-better-paths-forward
#16
LETTER
William V Stoecker, Aaron Carson, Vu H Nguyen, Alex B Willis, Justin G Cole, Ryan K Rader
The report by Khosla et al.(1) highlights a critical gap in osteoporosis management: patients who need pharmacological therapy are either not being prescribed these medications or fail to take them, especially bisphosphonates. We suggest three changes to the paths proposed by the authors to further improve osteoporosis treatment: new ways to guide patient decisions, extending new drug development to include therapies from complementary and alternative medicine, and new efforts in osteoporosis research. With enhanced osteoporosis treatment and lifestyle options, we have a better chance to find an approach suitable for each individual...
March 31, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370194/bone-marrow-adipose-tissue-the-first-40-years
#17
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 31, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370412/pthrp-12-48-modulates-the-bone-marrow-microenvironment-and-suppresses-human-osteoclast-differentiation-and-lifespan
#18
Archana Kamalakar, Charity L Washam, Nisreen S Akel, Bethany J Allen, Diarra K Williams, Frances L Swain, Kim Leitzel, Alan Lipton, Dana Gaddy, Larry J Suva
Bone is a common site for metastasis in breast cancer patients and is associated with a series of complications which significantly compromise patient survival, partially due to the advanced stage of disease at the time of detection. Currently, no clinically-approved biomarkers can identify or predict the development of bone metastasis. We recently identified a unique peptide fragment of parathyroid hormone-related protein (PTHrP), PTHrP(12-48), as a validated serum biomarker in breast cancer patients that correlates with and predicts the presence of bone metastases...
March 29, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370407/bps804-anti-sclerostin-antibody-in-adults-with-moderate-osteogenesis-imperfecta-results-of-a-randomized-phase-2a-trial
#19
Francis H Glorieux, Jean-Pierre Devogelaer, Michaela Durigova, Stefan Goemaere, Sarah Hemsley, Franz Jakob, Uwe Junker, Jon Ruckle, Lothar Seefried, Peter J Winkle
TRIAL DESIGN: This 21-week, open-label, phase 2a trial aimed to evaluate the pharmacodynamics and safety of multiple, escalating infusions of BPS804, a neutralizing, anti-sclerostin antibody, in adults with moderate osteogenesis imperfecta (OI). METHODS: Patients received BPS804 (three escalating doses each separated by 2 weeks [5, 10 and 20 mg/kg]) or no treatment (reference group). The primary efficacy endpoints were mean changes from baseline to day 43 in: procollagen type 1 N-terminal propeptide (P1NP), procollagen type 1 C-terminal propeptide (P1CP), bone-specific alkaline phosphatase (BSAP), osteocalcin (OC) and type 1 collagen cross-linked C-telopeptide (CTX-1)...
March 29, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28370342/bone-mineral-density-increases-in-trans-persons-after-one-year-hormonal-treatment-a-multicenter-prospective-observational-study
#20
C M Wiepjes, M C Vlot, M Klaver, N M Nota, Cjm de Blok, R T de Jongh, P Lips, A C Heijboer, A D Fisher, T Schreiner, G T'Sjoen, M den Heijer
Sex steroids are important determinants of bone acquisition and bone homeostasis. Cross-sex hormonal treatment (CHT) in transgender persons can affect bone mineral density (BMD). The aim of this study is to investigate in a prospective observational multicenter study the first-year effects of CHT on BMD in transgender persons. 231 transwomen and 199 transmen were included who completed the first year of CHT. Transwomen were treated with cyproterone acetate and oral or transdermal estradiol, transmen received transdermal or intramuscular testosterone...
March 29, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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