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https://www.readbyqxmd.com/read/30419075/activation-of-trigeminal-ganglion-satellite-glial-cells-in-cfa-induced-tooth-pulp-pain-in-rats
#1
Helena F Filippini, Paulo A Scalzilli, Kesiane M Costa, Raquel D S Freitas, Maria M Campos
This study further investigated the mechanisms underlying the rat model of tooth pulp inflammatory pain elicited by complete Freund's adjuvant (CFA), in comparison to other pulpitis models. Pulps of the left maxillary first molars were accessed. In the CFA group, the pulps were exposed, and CFA application was followed by dental sealing. In the open group, the pulps were left exposed to the oral cavity. For the closed group, the pulps were exposed, and the teeth were immediately sealed. Naïve rats were used as negative controls...
2018: PloS One
https://www.readbyqxmd.com/read/30419074/determining-minimal-output-sets-that-ensure-structural-identifiability
#2
D Joubert, J D Stigter, J Molenaar
The process of inferring parameter values from experimental data can be a cumbersome task. In addition, the collection of experimental data can be time consuming and costly. This paper covers both these issues by addressing the following question: "Which experimental outputs should be measured to ensure that unique model parameters can be calculated?". Stated formally, we examine the topic of minimal output sets that guarantee a model's structural identifiability. To that end, we introduce an algorithm that guides a researcher as to which model outputs to measure...
2018: PloS One
https://www.readbyqxmd.com/read/30419073/functional-diversity-and-nutritional-content-in-a-deep-sea-faunal-assemblage-through-total-lipid-lipid-class-and-fatty-acid-analyses
#3
Camilla Parzanini, Christopher C Parrish, Jean-François Hamel, Annie Mercier
Lipids are key compounds in marine ecosystems being involved in organism growth, reproduction, and survival. Despite their biological significance and ease of measurement, the use of lipids in deep-sea studies is limited, as is our understanding of energy and nutrient flows in the deep ocean. Here, a comprehensive analysis of total lipid content, and lipid class and fatty acid composition, was used to explore functional diversity and nutritional content within a deep-sea faunal assemblage comprising 139 species from 8 phyla, including the Chordata, Arthropoda, and Cnidaria...
2018: PloS One
https://www.readbyqxmd.com/read/30419071/blood-stage-plasmodium-vivax-antibody-dynamics-in-a-low-transmission-setting-a-nine-year-follow-up-study-in-the-amazon-region
#4
Camilla V Pires, Jessica R S Alves, Barbara A S Lima, Ruth B Paula, Helena L Costa, Leticia M Torres, Taís N Sousa, Irene S Soares, Bruno A M Sanchez, Cor J F Fontes, Francis B Ntumngia, John H Adams, Flora S Kano, Luzia H Carvalho
Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even in low malaria transmission settings, such as the Amazon basin, where progress in malaria control has caused a remarkable reduction in case incidence, a recent increase in P. vivax transmission demonstrates the continued vulnerability of P.vivax-exposed populations. As part of a search for complementary approaches to P.vivax surveillance in areas in which adults are the majority of the exposed-population, here we evaluated the potential of serological markers covering a wide range of immunogenicity to estimate malaria transmission trends...
2018: PloS One
https://www.readbyqxmd.com/read/30419070/deletion-of-a-conserved-transcript-pg_rs02100-expressed-during-logarithmic-growth-in-porphyromonas-gingivalis-results-in-hyperpigmentation-and-increased-tolerance-to-oxidative-stress
#5
Priscilla L Phillips, Leticia Reyes, Edith M Sampson, Evan A Murrell, Joan A Whitlock, Ann Progulske-Fox
The oral obligate anaerobe Porphyromonas gingivalis possesses a small conserved transcript PG_RS02100 of unknown function we previously identified using small RNA-seq analysis as expressed during logarithmic growth. In this study, we sought to determine if PG_RS02100 plays a role in P. gingivalis growth or stress response. We show that a PG_RS02100 deletion mutant's (W83Δ514) ability to grow under anaerobic conditions was no different than wildtype (W83), but it was better able to survive hydrogen peroxide exposure when cultured under heme limiting growth conditions, and was more aerotolerant when plated on enriched whole blood agar and exposed to atmospheric oxygen...
2018: PloS One
https://www.readbyqxmd.com/read/30419069/c-vddb-a-multi-omics-expression-profiling-database-for-a-knowledge-driven-approach-in-cardiovascular-disease-cvd
#6
Marco Fernandes, Alisha Patel, Holger Husi
The cardiovascular disease (C/VD) database is an integrated and clustered information resource that covers multi-omic studies (microRNA, genomics, proteomics and metabolomics) of cardiovascular-related traits with special emphasis on coronary artery disease (CAD). This resource was built by mining existing literature and public databases and thereafter manual biocuration was performed. To enable integration of omic data from distinct platforms and species, a specific ontology was applied to tie together and harmonise multi-level omic studies based on gene and protein clusters (CluSO) and mapping of orthologous genes (OMAP) across species...
2018: PloS One
https://www.readbyqxmd.com/read/30419068/lack-of-modulatory-effect-of-the-scn5a-r1193q-polymorphism-on-cardiac-fast-na-current-at-body-temperature
#7
Masayoshi Abe, Koshi Kinoshita, Kenta Matsuoka, Takahito Nakada, Kimiaki Miura, Yukiko Hata, Naoki Nishida, Toshihide Tabata
SCN5A encodes the main subunit of the NaV1.5 channel, which mediates the fast Na+ current responsible for generating cardiac action potentials. The single nucleotide polymorphism SCN5A(R1193Q), which results in an amino acid replacement in the subunit, is common in East Asia. SCN5A(R1193Q) is often identified in patients with type 3 long QT syndrome and Brugada syndrome. However, its linkage to arrhythmic disorders is under debate. Previous electrophysiological studies performed at room temperature inconsistently reported the gain- or loss-of-function effect of SCN5A(R1193Q) on the NaV1...
2018: PloS One
https://www.readbyqxmd.com/read/30419067/emerging-shiga-toxin-producing-escherichia-coli-serogroup-o80-associated-hemolytic-and-uremic-syndrome-in-france-2013-2016-differences-with-other-serogroups
#8
Brecht Ingelbeen, Mathias Bruyand, Patricia Mariani-Kurkjian, Simon Le Hello, Kostas Danis, Cécile Sommen, Stéphane Bonacorsi, Henriette de Valk
To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013-16. STEC was isolated from 153/521 (30%) reported HUS cases: 45 serogroup O80, 46 O157 and 62 other serogroups. Median ages were 1.1 years, 4.0 years and 1.8 years, respectively. O80 infected patients were less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0...
2018: PloS One
https://www.readbyqxmd.com/read/30419066/exposure-to-a-musically-enriched-environment-its-relationship-with-executive-functions-short-term-memory-and-verbal-iq-in-primary-school-children
#9
Artur C Jaschke, Henkjan Honing, Erik J A Scherder
BACKGROUND: Previous literature has shown a putative relationship between playing a musical instrument and a benefit in various cognitive domains. However, to date it still remains unknown whether the exposure to a musically-enriched environment instead of playing an instrument yourself might also increase cognitive domains such as language, mathematics or executive sub-functions such as for example planning or working memory in primary school children. DESIGN: Cross-sectional...
2018: PloS One
https://www.readbyqxmd.com/read/30419065/an-urgent-need-for-hiv-testing-among-men-who-have-sex-with-men-and-transgender-women-in-bamako-mali-low-awareness-of-hiv-infection-and-viral-suppression-among-those-living-with-hiv
#10
Avi J Hakim, Kelsey Coy, Padmaja Patnaik, Nouhoum Telly, Tako Ballo, Bouyagui Traore, Seydou Doumbia, Maria Lahuerta
Despite the high HIV prevalence among men who have sex with men (MSM) and transgender women (TGW), there are limited data on progress on their respective HIV antiretroviral treatment (ART) cascades to identify progress and gaps in meeting UNAIDS 90-90-90 targets. We conducted a respondent-driven sampling survey of MSM and TGW in Bamako, Mali from October 2014 to February 2015. We describe the HIV treatment cascade for MSM and TGW, identify correlates of being unaware of HIV-infected status and having unsuppressed viral load levels, and estimate proportion of recent infections...
2018: PloS One
https://www.readbyqxmd.com/read/30419064/ssr-linkage-map-of-interspecific-populations-derived-from-gossypium-trilobum-and-gossypium-thurberi-and-determination-of-genes-harbored-within-the-segregating-distortion-regions
#11
Pengcheng Li, Joy Nyangasi Kirungu, Hejun Lu, Richard Odongo Magwanga, Pu Lu, Xiaoyan Cai, Zhongli Zhou, Xingxing Wang, Yuqing Hou, Yuhong Wang, Yanchao Xu, Renhai Peng, Yingfan Cai, Yun Zhou, Kunbo Wang, Fang Liu
Wild cotton species have significant agronomic traits that can be introgressed into elite cultivated varieties. The use of a genetic map is important in exploring, identification and mining genes which carry significant traits. In this study, 188 F2mapping individuals were developed from Gossypium thurberi (female) and Gossypium trilobum (male), and were genotyped by using simple sequence repeat (SSR) markers. A total of 12,560 simple sequence repeat (SSR) markers, developed by Southwest University, thus coded SWU were screened out of which only 994 were found to be polymorphic, and 849 markers were linked in all the 13 chromosomes...
2018: PloS One
https://www.readbyqxmd.com/read/30419063/predicting-functional-networks-from-region-connectivity-profiles-in-task-based-versus-resting-state-fmri-data
#12
Javier Rasero, Hannelore Aerts, Marlis Ontivero Ortega, Jesus M Cortes, Sebastiano Stramaglia, Daniele Marinazzo
Intrinsic Connectivity Networks, patterns of correlated activity emerging from "resting-state" BOLD time series, are increasingly being associated with cognitive, clinical, and behavioral aspects, and compared with patterns of activity elicited by specific tasks. We study the reconfiguration of brain networks between task and resting-state conditions by a machine learning approach, to highlight the Intrinsic Connectivity Networks (ICNs) which are more affected by the change of network configurations in task vs...
2018: PloS One
https://www.readbyqxmd.com/read/30419062/association-of-specific-gene-mutations-derived-from-machine-learning-with-survival-in-lung-adenocarcinoma
#13
Han-Jun Cho, Soonchul Lee, Young Geon Ji, Dong Hyeon Lee
Lung cancer is the second most common cancer in the United States and the leading cause of mortality in cancer patients. Biomarkers predicting survival of patients with lung cancer have a profound effect on patient prognosis and treatment. However, predictive biomarkers for survival and their relevance for lung cancer are not been well known yet. The objective of this study was to perform machine learning with data from The Cancer Genome Atlas of patients with lung adenocarcinoma (LUAD) to find survival-specific gene mutations that could be used as survival-predicting biomarkers...
2018: PloS One
https://www.readbyqxmd.com/read/30419061/rapidly-evolving-changes-and-gene-loss-associated-with-host-switching-in-corynebacterium-pseudotuberculosis
#14
Marcus Vinicius Canário Viana, Arne Sahm, Aristóteles Góes Neto, Henrique Cesar Pereira Figueiredo, Alice Rebecca Wattam, Vasco Azevedo
Phylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that were isolated from different hosts, including representatives of the Ovis and Equi biovars. A total of 27 genes were identified as undergoing adaptive changes. An analysis of the clades within this species and these biovars, the genes specific to each branch, and the genes responding to selective pressure show clear differences, indicating that adaptation and specialization is occurring in different clades...
2018: PloS One
https://www.readbyqxmd.com/read/30419060/automatic-detection-of-mind-wandering-in-a-simulated-driving-task-with-behavioral-measures
#15
Yuyu Zhang, Takatsune Kumada
Mind wandering (MW) is extremely common during driving and is often accompanied by performance losses. This study investigated the use of driving behavior measurements to automatically detect mind wandering state in the driving task. In the experiment, participants (N = 40) performed a car-following task in a driving simulator and reported, upon hearing a tone, whether they were experiencing mind wandering or not. Supervised machine learning techniques were applied to classify MW-absent versus MW-present state, using both driver-independent and driver-dependent modeling methods...
2018: PloS One
https://www.readbyqxmd.com/read/30419059/a-systematic-review-on-the-impact-of-gestational-lyme-disease-in-humans-on-the-fetus-and-newborn
#16
Lisa A Waddell, Judy Greig, L Robbin Lindsay, Alison F Hinckley, Nicholas H Ogden
Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Data were summarized descriptively and random effects meta-analysis (MA) was used where appropriate. The SR identified 45 relevant studies, 29 describing 59 cases reported as gestational LD in the United States, Europe, and Asia (1969-2017)...
2018: PloS One
https://www.readbyqxmd.com/read/30419058/dosimetric-and-radiobiological-comparison-in-different-dose-calculation-grid-sizes-between-acuros-xb-and-anisotropic-analytical-algorithm-for-prostate-vmat
#17
Kyeong-Hyeon Kim, Jin-Beom Chung, Tae Suk Suh, Sang-Won Kang, Seong-Hee Kang, Keun-Yong Eom, Changhoon Song, In-Ah Kim, Jae-Sung Kim
To investigate feasible treatment planning parameters, we aimed to evaluate the dosimetric and radiobiological impact of the dose calculation algorithm and grid size in the volumetric modulated arc therapy (VMAT) plan for prostate cancer. Twenty patients were selected, and the treatment plans were initially generated with anisotropic analytical algorithm (AAA) and recalculated with Acuros XB (AXB) algorithm. Various dose grids were used for AXB (1, 2, and 3 mm) and AAA (1, 3, and 5 mm) plan. Dosimetric parameters such as homogeneity index (HI) and conformity index (CI), and radiobiological parameters such as tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/30419057/perfect-metamaterial-absorber-with-high-fractional-bandwidth-for-solar-energy-harvesting
#18
Mohammad Jakir Hossain, Mohammad Rashed Iqbal Faruque, Mohammad Tariqul Islam
A new perfect metamaterial absorber (PMA) with high fractional bandwidth (FBW) is examined and verified for solar energy harvesting. Solar cells based on perfect metamaterial give a chance to increase the efficiency of the system by intensifying the solar electromagnetic wave that incident on the device. The designed structure is mostly offered in the visible frequency range so as to exploit the solar's energy efficiently. Parametric investigations with regard to the measurements of the design structure are fulfilled to characterize the absorber...
2018: PloS One
https://www.readbyqxmd.com/read/30419056/the-cut-off-values-of-surrogate-measures-for-insulin-resistance-in-the-korean-population-according-to-the-korean-genome-and-epidemiology-study-koges
#19
Bongyoung Kim, Hyun Young Choi, Wonhee Kim, Chiwon Ahn, Juncheol Lee, Jae Guk Kim, Jihoon Kim, Hyungoo Shin, Jae Myung Yu, Shinje Moon
OBJECTIVE: The current methods available for determining insulin resistance are complicated; hence, they are only applicable to small-scale studies. Therefore, this study aimed to classify the characteristics of surrogate measures for insulin resistance and establish valid cut-off values for predicting the development of type 2 diabetes mellitus (DM) in Korean populations. METHODS: This prospective study included 7,643 participants aged 40-69 years from the Ansung-Ansan cohort database (2001-2012)...
2018: PloS One
https://www.readbyqxmd.com/read/30419055/the-importance-of-culture-in-predicting-environmental-behavior-in-middle-school-students-on-hawai-i-island
#20
Rachelle K Gould, Daniel H Krymkowski, Nicole M Ardoin
Researchers have investigated the factors that influence environmental behavior for decades. Two often-investigated phenomena, connectedness to nature and self-efficacy, often correlate with environmental behavior, yet researchers rarely analyze those correlations along with underlying cultural factors. We suggest that this is a substantial oversight and hypothesize that cultural factors affect environmental behavior, particularly through an interplay with the connectedness to nature and self-efficacy constructs...
2018: PloS One
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