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PloS One

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https://www.readbyqxmd.com/read/28931094/ethnicity-and-skin-autofluorescence-based-risk-engines-for-cardiovascular-disease-and-diabetes-mellitus
#1
Muhammad Saeed Ahmad, Torben Kimhofer, Sultan Ahmad, Mohammed Nabil AlAma, Hala Hisham Mosli, Salwa Ibrahim Hindawi, Dennis O Mook-Kanamori, Katarína Šebeková, Zoheir Abdullah Damanhouri, Elaine Holmes
Skin auto fluorescence (SAF) is used as a proxy for the accumulation of advanced glycation end products (AGEs) and has been proposed to stratify patients into cardiovascular disease (CVD) and diabetes mellitus (DM) risk groups. This study evaluates the effects of seven different ethnicities (Arab, Central-East African, Eastern Mediterranean, European, North African, South Asian and Southeast Asian) and gender on SAF as well as validating SAF assessment as a risk estimation tool for CVD and DM in an Arabian cohort...
2017: PloS One
https://www.readbyqxmd.com/read/28931093/synthesis-of-udp-apiose-in-bacteria-the-marine-phototroph-geminicoccus-roseus-and-the-plant-pathogen-xanthomonas-pisi
#2
James Amor Smith, Maor Bar-Peled
The branched-chain sugar apiose was widely assumed to be synthesized only by plant species. In plants, apiose-containing polysaccharides are found in vascularized plant cell walls as the pectic polymers rhamnogalacturonan II and apiogalacturonan. Apiosylated secondary metabolites are also common in many plant species including ancestral avascular bryophytes and green algae. Apiosyl-residues have not been documented in bacteria. In a screen for new bacterial glycan structures, we detected small amounts of apiose in methanolic extracts of the aerobic phototroph Geminicoccus roseus and the pathogenic soil-dwelling bacteria Xanthomonas pisi...
2017: PloS One
https://www.readbyqxmd.com/read/28931092/the-genome-wide-associated-candidate-gene-znf804a-and-psychosis-proneness-evidence-of-sex-modulated-association
#3
Marta de Castro-Catala, Aurea Mora-Solano, Thomas R Kwapil, Paula Cristóbal-Narváez, Tamara Sheinbaum, Anna Racioppi, Neus Barrantes-Vidal, Araceli Rosa
BACKGROUND: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia. AIM: The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28931090/correction-long-term-oncological-outcome-of-thymoma-and-thymic-carcinoma-an-analysis-of-235-cases-from-a-single-institution
#4
Yen-Chiang Tseng, Yen-Han Tseng, Hua-Lin Kao, Chih-Cheng Hsieh, Teh-Ying Chou, Yih-Gang Goan, Wen-Hu Hsu, Han-Shui Hsu
[This corrects the article DOI: 10.1371/journal.pone.0179527.].
2017: PloS One
https://www.readbyqxmd.com/read/28931089/advanced-glycation-end-products-dietary-restriction-effects-on-bacterial-gut-microbiota-in-peritoneal-dialysis-patients-a-randomized-open-label-controlled-trial
#5
Rabi Yacoub, Melinda Nugent, Weijin Cai, Girish N Nadkarni, Lee D Chaves, Sham Abyad, Amanda M Honan, Shruthi A Thomas, Wei Zheng, Sujith A Valiyaparambil, Mark A Bryniarski, Yijun Sun, Michael Buck, Robert J Genco, Richard J Quigg, John C He, Jaime Uribarri
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored the effects of dietary AGEs on the gut bacterial microbiota composition in similar patients. AGEs play an important role in the development and progression of cardiovascular (CVD) disease. Plasma concentrations of different bacterial products have been shown to predict the risk of incident major adverse CVD events independently of traditional CVD risk factors, and experimental animal models indicates a possible role AGEs might have on the gut microbiota population...
2017: PloS One
https://www.readbyqxmd.com/read/28931088/an-integrated-nutrition-and-health-program-package-on-iycn-improves-breastfeeding-but-not-complementary-feeding-and-nutritional-status-in-rural-northern-india-a-quasi-experimental-randomized-longitudinal-study
#6
Veena Singh, Saifuddin Ahmed, Michele L Dreyfuss, Usha Kiran, Deepika N Chaudhery, Vinod K Srivastava, Ramesh C Ahuja, Abdullah H Baqui, Gary L Darmstadt, Mathuram Santosham, Keith P West
BACKGROUND: Undernutrition below two years of age remains a major public health problem in India. We conducted an evaluation of an integrated nutrition and health program that aimed to improve nutritional status of young children by improving breast and complementary feeding practices over that offered by the Government of India's standard nutrition and health care program. METHODS: In Uttar Pradesh state, through multi-stage cluster random sampling, 81 villages in an intervention district and 84 villages in a comparison district were selected...
2017: PloS One
https://www.readbyqxmd.com/read/28931087/microbial-analysis-of-zetaproteobacteria-and-co-colonizers-of-iron-mats-in-the-troll-wall-vent-field-arctic-mid-ocean-ridge
#7
Jan Vander Roost, Ingunn Hindenes Thorseth, Håkon Dahle
Over the last decade it has become increasingly clear that Zetaproteobacteria are widespread in hydrothermal systems and that they contribute to the biogeochemical cycling of iron in these environments. However, how chemical factors control the distribution of Zetaproteobacteria and their co-occurring taxa remains elusive. Here we analysed iron mats from the Troll Wall Vent Field (TWVF) located at the Arctic Mid-Ocean Ridge (AMOR) in the Norwegian-Greenland Sea. The samples were taken at increasing distances from high-temperature venting chimneys towards areas with ultraslow low-temperature venting, encompassing a large variety in geochemical settings...
2017: PloS One
https://www.readbyqxmd.com/read/28931086/re-evaluation-of-the-interrelationships-among-the-behavioral-tests-in-rats-exposed-to-chronic-unpredictable-mild-stress
#8
Congli Hu, Ying Luo, Hong Wang, Shengnan Kuang, Guojuan Liang, Yang Yang, Shaoshan Mai, Junqing Yang
The chronic unpredictable mild stress model of depression has been widely used as an experimental tool to investigate human psychopathology. Our objective was to provide an update on the validity and reliability of the chronic unpredictable mild stress model, by analyzing the interrelationships among the indexes using stepwise discriminant analysis and Pearson correlation coefficient to examine the possible combinations. We evaluated the depressive rats in both the presence and the absence of chronic unpredictable mild stress, using weight change, percentage of sucrose preference, coat state, splash test, open-field test, elevated plus-maze test, forced swimming test, and Morris water maze test...
2017: PloS One
https://www.readbyqxmd.com/read/28931084/barcoding-snakeheads-teleostei-channidae-revisited-discovering-greater-species-diversity-and-resolving-perpetuated-taxonomic-confusions
#9
Cecilia Conte-Grand, Ralf Britz, Neelesh Dahanukar, Rajeev Raghavan, Rohan Pethiyagoda, Heok Hui Tan, Renny K Hadiaty, Norsham S Yaakob, Lukas Rüber
Snakehead fishes of the family Channidae are predatory freshwater teleosts from Africa and Asia comprising 38 valid species. Snakeheads are important food fishes (aquaculture, live food trade) and have been introduced widely with several species becoming highly invasive. A channid barcode library was recently assembled by Serrao and co-workers to better detect and identify potential and established invasive snakehead species outside their native range. Comparing our own recent phylogenetic results of this taxonomically confusing group with those previously reported revealed several inconsistencies that prompted us to expand and improve on previous studies...
2017: PloS One
https://www.readbyqxmd.com/read/28931082/barcoding-atlantic-canada-s-mesopelagic-and-upper-bathypelagic-marine-fishes
#10
Ellen L Kenchington, Shauna M Baillie, Trevor J Kenchington, Paul Bentzen
DNA barcode sequences were developed from 557 mesopelagic and upper bathypelagic teleost specimens collected in waters off Atlantic Canada. Confident morphological identifications were available for 366 specimens, of 118 species and 93 genera, which yielded 328 haplotypes. Five of the species were novel to the Barcode of Life Database (BOLD). Most of the 118 species conformed to expectations of monophyly and the presence of a "barcode gap", though some known weaknesses in existing taxonomy were confirmed and a deficiency in published keys was revealed...
2017: PloS One
https://www.readbyqxmd.com/read/28931081/female-reproductive-success-and-calf-survival-in-a-north-sea-coastal-bottlenose-dolphin-tursiops-truncatus-population
#11
Kevin P Robinson, Texa M C Sim, Ross M Culloch, Thomas S Bean, Isabel Cordoba Aguilar, Sonja M Eisfeld, Miranda Filan, Gary N Haskins, Genevieve Williams, Graham J Pierce
Between-female variation in reproductive output provides a strong measure of individual fitness and a quantifiable measure of the health of a population which may be highly informative to management. In the present study, we examined reproductive traits in female bottlenose dolphins from the east coast of Scotland using longitudinal sightings data collected over twenty years. From a total of 102 females identified between 1997 and 2016, 74 mothers produced a collective total of 193 calves. Females gave birth from 6 to 13 years of age with a mean age of 8...
2017: PloS One
https://www.readbyqxmd.com/read/28931080/low-serum-level-of-mir-485-3p-predicts-poor-survival-in-patients-with-glioblastoma
#12
Zhi-Qiang Wang, Mei-Yin Zhang, Mei-Ling Deng, Nuo-Qing Weng, Hui-Yun Wang, Shao-Xiong Wu
MicroRNAs (miRNAs) are short noncoding RNAs that play critical roles in human malignancies and can be used as biomarkers for cancer. Until now, a number of biomarkers for prognosis of glioblastoma (GBM) have been reported in tumor tissues but only a few biomarkers in circulating fluid. Using a custom microarray, we previously identified 19 differentially expressed miRNAs in serum of patients with GBM. In this study, we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM...
2017: PloS One
https://www.readbyqxmd.com/read/28931079/an-evidence-based-evaluation-of-transferrable-skills-and-job-satisfaction-for-science-phds
#13
Melanie Sinche, Rebekah L Layton, Patrick D Brandt, Anna B O'Connell, Joshua D Hall, Ashalla M Freeman, Jessica R Harrell, Jeanette Gowen Cook, Patrick J Brennwald
PhD recipients acquire discipline-specific knowledge and a range of relevant skills during their training in the life sciences, physical sciences, computational sciences, social sciences, and engineering. Empirically testing the applicability of these skills to various careers held by graduates will help assess the value of current training models. This report details results of an Internet survey of science PhDs (n = 8099) who provided ratings for fifteen transferrable skills. Indeed, analyses indicated that doctoral training develops these transferrable skills, crucial to success in a wide range of careers including research-intensive (RI) and non-research-intensive (NRI) careers...
2017: PloS One
https://www.readbyqxmd.com/read/28931078/microgeographic-population-structuring-of-aedes-aegypti-diptera-culicidae
#14
André Barretto Bruno Wilke, Ramon Wilk-da-Silva, Mauro Toledo Marrelli
Aedes aegypti is one of the species most favored by changes in the environment caused by urbanization. Its abundance increases rapidly in the face of such changes, increasing the risk of disease transmission. Previous studies have shown that mosquito species that have adapted to anthropogenic environmental changes benefit from urbanization and undergo population expansion. In light of this, we used microsatellite markers to explore how urbanization processes may be modulating Ae. aegypti populations collected from three areas with different levels of urbanization in the city of São Paulo, Brazil...
2017: PloS One
https://www.readbyqxmd.com/read/28931077/detection-of-bacterial-pathogens-including-potential-new-species-in-human-head-lice-from-mali
#15
Nadia Amanzougaghene, Florence Fenollar, Abdoul Karim Sangaré, Mahamadou S Sissoko, Ogobara K Doumbo, Didier Raoult, Oleg Mediannikov
In poor African countries, where no medical and biological facilities are available, the identification of potential emerging pathogens of concern at an early stage is challenging. Head lice, Pediculus humanus capitis, have a short life, feed only on human blood and do not transmit pathogens to their progeny. They are, therefore, a perfect tool for the xenodiagnosis of current or recent human infection. This study assessed the occurrence of bacterial pathogens from head lice collected in two rural villages from Mali, where a high frequency of head lice infestation had previously been reported, using molecular methods...
2017: PloS One
https://www.readbyqxmd.com/read/28931076/ghrelin-mediated-inhibition-of-the-tsh-stimulated-function-of-differentiated-human-thyrocytes-ex-vivo
#16
Maria Barington, Marianne Møller Brorson, Jacob Hofman-Bang, Åse Krogh Rasmussen, Birgitte Holst, Ulla Feldt-Rasmussen
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28931075/excitability-is-increased-in-hippocampal-ca1-pyramidal-cells-of-fmr1-knockout-mice
#17
M Angeles Luque, Pablo Beltran-Matas, M Carmen Marin, Blas Torres, Luis Herrero
Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual disability, learning impairment, hyperactivity, seizures and anxiety. Fmr1 knockout (KO) mice do not express FMRP and, as a result, reproduce some FXS behavioral abnormalities. While intrinsic and synaptic properties of excitatory cells in various part of the brain have been studied in Fmr1 KO mice, a thorough analysis of action potential characteristics and input-output function of CA1 pyramidal cells in this model is lacking...
2017: PloS One
https://www.readbyqxmd.com/read/28931074/genetic-and-phenotypic-effects-of-chromosome-segments-introgressed-from-gossypium-barbadense-into-gossypium-hirsutum
#18
Weiwu Song, Mi Wang, Wei Su, Quanwei Lu, Xianghui Xiao, Juan Cai, Zhen Zhang, Shaoqi Li, Pengtao Li, Juwu Gong, Wankui Gong, Haihong Shang, Aiying Liu, Junwen Li, Tingting Chen, Qun Ge, Yuzhen Shi, Youlu Yuan
MBI9915 is an introgression cotton line with excellent fiber quality. It was obtained by advanced backcrossing and continuous inbreeding from an interspecific cross between the upland cotton (Gossypium hirsutum) cultivar CCRI36 as the recurrent parent and the sea island cotton (G. barbadense) cultivar Hai1, as the donor parent. To study the genetic effects of the introgressed chromosome segments in G. hirsutum, an F2 secondary segregating population of 1537 individuals was created by crossing MBI9915 and CCRI36, and an F2:3 population was created by randomly selecting 347 individuals from the F2 generation...
2017: PloS One
https://www.readbyqxmd.com/read/28931073/bacterial-and-diazotrophic-diversities-of-endophytes-in-dendrobium-catenatum-determined-through-barcoded-pyrosequencing
#19
Ou Li, Rong Xiao, Lihua Sun, Chenglin Guan, Dedong Kong, Xiufang Hu
As an epiphyte orchid, Dendrobium catenatum relies on microorganisms for requisite nutrients. Metagenome pyrosequencing based on 16S rRNA and nifH genes was used to characterize the bacterial and diazotrophic communities associated with D. catenatum collected from 5 districts in China. Based on Meta-16S rRNA sequencing, 22 bacterial phyla and 699 genera were identified, distributed as 125 genera from 8 phyla and 319 genera from 10 phyla shared by all the planting bases and all the tissues, respectively. The predominant Proteobacteria varied from 71...
2017: PloS One
https://www.readbyqxmd.com/read/28931072/high-prevalence-of-non-dipping-blood-pressure-and-vascular-stiffness-in-hiv-infected-south-africans-on-antiretrovirals
#20
M S Borkum, J M Heckmann, K Manning, J A Dave, N S Levitt, B L Rayner, N Wearne
BACKGROUND: HIV-infected individuals are at increased risk of tissue inflammation and accelerated vascular aging ('inflamm-aging'). Abnormal diurnal blood pressure (BP) rhythms such as non-dipping may contribute to an increased risk of cardiovascular and cerebrovascular events in HIV infected individuals. However, little data exists on ambulatory blood pressure (ABP) and measures of vascular stiffness in the black African HIV infected population. METHODS: This is a cross-sectional analysis of otherwise well, HIV infected outpatients on ART for >5 years...
2017: PloS One
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