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PloS One

Maria Fiorella Mazzeo, Giuseppina Cacace, Paolo Iovieno, Immacolata Massarelli, Stefania Grillo, Rosa Anna Siciliano
Constant global warming is one of the most detrimental environmental factors for agriculture causing significant losses in productivity as heat stress (HS) conditions damage plant growth and reproduction. In flowering plants such as tomato, HS has drastic repercussions on development and functionality of male reproductive organs and pollen. Response mechanisms to HS in tomato anthers and pollen have been widely investigated by transcriptomics; on the contrary, exhaustive proteomic evidences are still lacking...
2018: PloS One
Danielle Hunt, Lisa A Drake, James R Drake
Macrophages (MØs) are sentinels of the immune system that use pattern recognition receptors such as Toll-like receptors (TLR) to detect invading pathogens and immune receptors such as FcγR to sense the host's immune state. Crosstalk between these two signaling pathways allows the MØ to tailor the cell's overall response to prevailing conditions. However, the molecular mechanisms underlying TLR-FcγR crosstalk are only partially understood. Therefore, we employed an immunologically-relevant MØ stimulus, an inactivated gram-negative bacterium that bears TLR2 agonists but no TLR4 agonist (iBTLR2) opsonized with a monoclonal antibody (mAb-iBTLR2), as a tool to study FcγR regulation of TLR2-driven production of IL-6, a key inflammatory cytokine...
2018: PloS One
Bartosz Nizynski, Hanna Nieznanska, Robert Dec, Solomiia Boyko, Wojciech Dzwolak, Krzysztof Nieznanski
Amyloid aggregates of Tau protein have been implicated in etiology of many neurodegenerative disorders including Alzheimer's disease (AD). When amyloid growth is induced by seeding with preformed fibrils assembled from the same protein, structural characteristics of the seed are usually imprinted in daughter generations of fibrils. This so-called conformational memory effect may be compromised when the seeding involves proteins with non-identical sequences leading to the emergence of distinct structural variants of fibrils (amyloid 'strains')...
2018: PloS One
Matteo Fallico, Andrea Russo, Antonio Longo, Alfredo Pulvirenti, Teresio Avitabile, Vincenza Bonfiglio, Niccolò Castellino, Gilda Cennamo, Michele Reibaldi
BACKGROUND: Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. OBJECTIVE: To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies...
2018: PloS One
Ruimei Zhang, Xiangyu Xi, Chunying Wang, Yong Pan, Changhua Ge, Liying Zhang, Shuo Zhang, Huimei Liu
BACKGROUND: Interleukin 2 (IL-2) is a cytokine secreted by activated T cells. Studies exploring recombinant human interleukin 2 (rhuIL-2) as an adjunctive immunotherapeutic agent to treat tuberculosis (TB) have shown variable results; however, the true therapeutic efficacy of rhuIL-2 administration in TB patients has not been determined. METHODS: A systematic review to identify publications exploring the association between rhuIL-2-based immunotherapy for TB and outcomes (sputum culture conversion, sputum smear conversion, radiographic changes, and leukocyte phenotype changes) in patients with pulmonary TB published before June 8, 2018 was performed...
2018: PloS One
Hua-Wei Huang, Li-Mei Yan, Yan-Lin Yang, Xuan He, Xiu-Mei Sun, Yu-Mei Wang, Guo-Bin Zhang, Jian-Xin Zhou
Postoperative agitation frequently occurs after general anesthesia and may be associated with serious consequences. However, studies in neurosurgical patients have been inadequate. We aimed to investigate the incidence and risk factors for early postoperative agitation in patients after craniotomy, specifically focusing on the association between postoperative pneumocephalus and agitation. Adult intensive care unit admitted patients after elective craniotomy under general anesthesia were consecutively enrolled...
2018: PloS One
Hari Setyowibowo, Fredrick Dermawan Purba, Joke A M Hunfeld, Aulia Iskandarsyah, Sawitri S Sadarjoen, Jan Passchier, Marit Sijbrandij
OBJECTIVES: Breast cancer (BC) is prevalent in low and middle-income countries (LMICs) where the majority of cases are diagnosed in late stages. The aims of this study were: (1) to assess quality of life (QOL) and health status of Indonesian women with BC symptoms before definitive diagnosis; (2) to compare QOL and health status between women with BC symptoms before definitive diagnosis and Indonesian women in general; (3) to evaluate the association between demographic variables (age, residence, social economic status and education level) and QOL within the Indonesian women with BC symptoms before definitive diagnosis...
2018: PloS One
Mrittika Barua, Francien Van Driel, Willy Jansen
When they do not meet norms related to sexuality and reproduction, Bangladeshi women often face abandonment and are thus deprived of an active sexual life, a marital relationship, and motherhood. Little is known about how a stigmatised disease such as tuberculosis (TB) may constrain the reproductive health and sexual lives of women. This article, derived from a larger study on the impact of TB on women's sexual and reproductive health and rights in Narsingdi district and Dhaka, Bangladesh, aims to fill this gap...
2018: PloS One
Dong-Hyeok Kim, Dae-In Lee, Jinhee Ahn, Kwang-No Lee, Seung-Young Roh, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
The interruption of oral anticoagulation therapy (OAC) after CA of atrial fibrillation (AF) is controversial. The purpose of this study was to evaluate the relationship between successful long-term outcomes of catheter resection and SR maintenance and ischemic stroke risk in Korea. We studied 1,548 consecutive patients who were followed up for more than 2 years after CA of AF. We investigated the incidence of ischemic stroke during long-term follow-up. Compared to the AF recurrence group (n = 619), the sinus rhythm (SR) maintenance group (n = 929) had more paroxysmal AF (74...
2018: PloS One
Ju-Fang Teng, Chien-Hsing Lee, Tai-Hao Hsu, Hui-Chen Lo
Polysaccharides derived from mushrooms have potential to control blood sugar, reduce insulin resistance and prevent diabetic complications. The intracellular polysaccharopeptides of Trametes versicolor (TV) have been used as immunologic and oncologic adjuvants. The aim of this study was to investigate the potential activities and mechanisms of extracellular polysaccharopeptides (ePSP) obtained from TV strain LH-1 on regulating glucose homeostasis. Human hepatoma HepG2 cells incubated with normal glucose (5...
2018: PloS One
(no author information available yet)
No abstract text is available yet for this article.
2018: PloS One
Lucas Monzani, Rosario Zurriaga, Gemma Victoria Espí López
The primary objective of this study was to explore the mechanisms and conditions whereby Tension-Type Headache (TTH) presenteeism relates to health-related loss of productivity as a result of both reduced physical and mental health. To this end, Structural Equation Modeling (SEM) was used to conduct a secondary data analysis of a randomized clinical trial involving 78 Tension-type Headache (TTH) patients. The results showed that TTH presenteeism did not directly relate to health-related loss of productivity, either due to physical, or mental health problems...
2018: PloS One
Hans van Dijk, Bertolt Meyer, Marloes van Engen
Information elaboration-the act of exchanging, discussing, and integrating information and perspectives through verbal communication-tends to be considered as the silver bullet that drives the performance of diverse teams. We challenge this notion by proposing that the effect of information elaboration on team performance depends on the accuracy of within-group competence attributions, i.e. the extent to which attributions of task competence among team members correspond with members' actual task competence...
2018: PloS One
Mitsuhiro Matsuo, Atsushi Katahata, Soichirou Satoh, Motomichi Matsuzaki, Mami Nomura, Ken-Ichiro Ishida, Yuji Inagaki, Junichi Obokata
Paulinella micropora is a rhizarian thecate amoeba, belonging to a photosynthetic Paulinella species group that has a unique organelle termed chromatophore, whose cyanobacterial origin is distinct from that of plant and algal chloroplasts. Because acquisition of the chromatophore was quite a recent event compared with that of the chloroplast ancestor, the Paulinella species are thought to be model organisms for studying the early process of primary endosymbiosis. To obtain insight into how endosymbiotically transferred genes acquire expression competence in the host nucleus, here we analyzed the 5' end sequences of the mRNAs of P...
2018: PloS One
(no author information available yet)
No abstract text is available yet for this article.
2018: PloS One
Sebastian Scheich, Rosalie Koenig, Anne C Wilke, Sarah Lindner, Claudia Reinheimer, Thomas A Wichelhaus, Michael Hogardt, Volkhard A J Kempf, Johanna Kessel, Sarah Weber, Hans Martin, Gesine Bug, Hubert Serve, Björn Steffen
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers potential cure to acute myeloid leukemia (AML) patients. However, infections with commensal bacteria are an important cause for non-relapse mortality (NRM). We have previously described the impact of multidrug-resistant organism (MDRO) colonization on the survival of allo-HSCT patients. In the aforementioned publication, according to consensus, we there did not consider the opportunistic gram-negative bacterium Stenotrophomonas maltophilia (S...
2018: PloS One
Yingming Xu, Kui Zhang, Jinlin Miao, Peng Zhao, Minghua Lv, Jia Li, Xianghui Fu, Xing Luo, Ping Zhu
OBJECTIVE: Pain management is a huge challenge in the treatment of rheumatoid arthritis (RA), and central sensitization is reportedly involved in the development of pain. The current study was undertaken to explore the possible role of N-methyl-D-aspartate receptors (NMDARs) in the spinal mechanism of central sensitization in RA using a collagen-induced arthritis (CIA) model. METHODS: Mechanical hypersensitivity was assessed in C57BL/6 mice, before and after the induction of CIA via administration of chick type II collagen...
2018: PloS One
Nobuyuki Mitsui, Satoshi Asakura, Keisuke Takanobu, Shinya Watanabe, Kuniyoshi Toyoshima, Yuki Kako, Yoichi M Ito, Ichiro Kusumi
BACKGROUND: Suicide has been a leading cause of death among young adult populations in Japan. The aim of this study was to predict major depressive episodes (MDEs) and suicide-related ideation among university students using the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI). METHODS: The subjects were 2194 university students who completed the PHQ-9 and TCI in the 1st year (T1) and the PHQ-9 in the 4th year (T2) of university...
2018: PloS One
Petra Pospíšilová, Philippe Alain Grange, Linda Grillová, Lenka Mikalová, Pervenche Martinet, Michel Janier, Annie Vermersch, Nadjet Benhaddou, Pascal Del Giudice, Isabelle Alcaraz, François Truchetet, Nicolas Dupin, David Šmajs
Treponema pallidum subsp. pallidum, the causative agent of sexually transmitted syphilis, detected in clinical samples from France, was subjected to molecular typing using the recently developed Multilocus Sequence Typing system. The samples (n = 133) used in this study were collected from 2010-2016 from patients with diagnosed primary or secondary syphilis attending outpatient centers or hospitals in several locations in France. Altogether, 18 different allelic profiles were found among the fully typed samples (n = 112)...
2018: PloS One
Helen Kathleen Crabb, Joanne Lee Allen, Joanne Maree Devlin, Simon Matthew Firestone, Colin Reginald Wilks, James Rudkin Gilkerson
The transmission of Salmonella enterica within a vertically integrated poultry operation was investigated longitudinally over an 18-month period (2013-2014). Thirty six percent of all samples collected (1503 of 4219) were positive for salmonellae with seven Salmonella enterica subsp. enterica serovars, and one Salmonella enterica subsp. salamae serovar detected. Both Salmonella enterica subsp. enterica serovars Infantis and Typhimurium were detected in all locations sampled. Salmonella Typhimurium was the most frequently detected serovar (63% of serotyped samples) with 8 phage types (PT) and 41 multiple-locus variable-number tandem-repeats analysis (MLVA) profiles identified...
2018: PloS One
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