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Tropical Medicine & International Health: TM & IH

Henry Maia Peixoto, Marcelo Augusto Mota Brito, Gustavo Adolfo Sierra Romero, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães de Lacerda, Maria Regina Fernandes de Oliveira
OBJECTIVE: The aim of this study was to estimate the incremental budget impact (IBI) of a rapid diagnostic test to detect G6PDd in male patients infected with Plasmodium vivax in the Brazilian Amazon, as compared to the routine protocol recommended in Brazil which does not include G6PDd testing. METHODS: The budget impact analysis was performed from the perspective of the Brazilian health system, in the Brazilian Amazon for the years 2013, 2014 and 2015. The analysis used a decision model to compare two scenarios: the first consisting of the routine recommended in Brazil which does not include prior diagnosis of dG6PD, and the second based on the use of RDT CareStart(™) G6PD (CS-G6PD) in all male subjects diagnosed with vivax malaria...
October 22, 2016: Tropical Medicine & International Health: TM & IH
A L Wilkinson, S H Pedersen, M Urassa, D Michael, A Andreasen, J Todd, S M Kinung'hi, J Changalucha, J M McDermid
OBJECTIVES: HIV infection is associated with chronic systemic inflammation, with or without antiretroviral therapy. Consequences for fetal growth are not understood, particularly in settings where multiple maternal infections and malnutrition are common. The study was designed to examine maternal systemic circulating and umbilical cord blood cytokine concentrations in relation to birth anthropometry in a Tanzanian prospective cohort. METHODS: A 9-plex panel of maternal plasma cytokines in HIV-positive (n=44) and HIV-negative (n=70) mothers and the same cytokines in umbilical cord blood collected at delivery was assayed...
October 20, 2016: Tropical Medicine & International Health: TM & IH
Patricia C Henwood, David C Mackenzie, Joshua S Rempell, Emily Douglass, Damas Dukundane, Andrew S Liteplo, Megan M Leo, Alice F Murray, Samuel Vaillancourt, Anthony J Dean, Resa E Lewiss, Stephen Rulisa, Elizabeth Krebs, A K Raja Rao, Emmanuel Rudakemwa, Vincent Rusanganwa, Patrick Kyanmanywa, Vicki E Noble
OBJECTIVE: We delivered a point-of-care ultrasound training programme in a resource-limited setting in Rwanda, and sought to determine participants' knowledge and skill retention. We also measured trainees' assessment of the usefulness of ultrasound in clinical practice. METHODS: This was a prospective cohort study of 17 Rwandan physicians participating in a point-of-care ultrasound training programme. The follow-up period was 1 year. Participants completed a 10-day ultrasound course, with follow-up training delivered over the subsequent 12 months...
October 19, 2016: Tropical Medicine & International Health: TM & IH
Mahamud-Ur Rashid, Zillur Rahman, Vanessa Burrowes, Jamie Perin, Munshi Mustafiz, Shirajum Monira, K M Saif-Ur-Rahman, Sazzadul Islam Bhuyian, Md Toslim Mahmud, R Bradley Sack, David Sack, Munirul Alam, Christine Marie George
OBJECTIVE: In urban Dhaka, Bangladesh, 30% of source water samples collected from the households of cholera patients had detectable Vibrio cholerae. These findings indicate an urgent need for a public health intervention for this population. The Crystal VC(®) dipstick test is a rapid method for detecting V.cholerae in stool and water. However, to date no study has investigated the use of the rapid dipstick test for household surveillance of stored drinking water. METHODS: The efficacy of the Crystal VC(®) dipstick test for detecting V...
October 18, 2016: Tropical Medicine & International Health: TM & IH
Philip M Massey, Ruth K Boansi, Jessica D Gipson, Rachel M Adams, Helene Riess, Thierno Dieng, Michael L Prelip, Deborah C Glik
OBJECTIVE: To examine HPV vaccine awareness and receptivity among adolescents and young adults in Senegal. METHODS: Participants from 6 high schools and 5 community centers across five regions of Senegal (n=2,286) completed a self-administered questionnaire in October and November 2014. The study assessed HPV awareness and receptivity toward receiving the HPV vaccine. Multivariable logistic regression explored statistically significant relationships between the predictor variables and both outcomes...
October 18, 2016: Tropical Medicine & International Health: TM & IH
Daniel Engelman, Reapi L Mataika, Joseph H Kado, Maureen Ah Kee, Susan Donath, Tom Parks, Andrew C Steer
OBJECTIVES: Echocardiographic screening for rheumatic heart disease (RHD) can detect subclinical cases, however adequate adherence to secondary antibiotic prophylaxis (SAP) is required to alter disease outcomes. We aimed to investigate the adherence to SAP among young people with RHD diagnosed through echocardiographic screening in Fiji, and to investigate factors associated with adherence. METHODS: Patients diagnosed with RHD through echocardiographic screening in Fiji from 2006 - 2014 were included...
October 12, 2016: Tropical Medicine & International Health: TM & IH
Marc Castellarnau, Javier Ramón-Azcón, Yolanda Gonzalez-Quinteiro, Jordi F López, Joan O Grimalt, María-Pilar Marco, Mark Nieuwenhuijsen, Albert Picado
OBJECTIVE: To present and evaluate simple, cost effective tests to determine the amount of insecticide on treated materials. METHODS: We developed and evaluated a competitive immunoassay on two different platforms: a label-free impedimetric biosensor (EIS biosensor) and a lateral flow. Both approaches were validated by gas chromatography (GC) and ELISA, gold standards for analytical methods and immunoassays, respectively. Finally, commercially available pyrethroid treated ITN samples were analysed...
October 7, 2016: Tropical Medicine & International Health: TM & IH
S Byberg, A B Fisker, A Rodrigues, I Balde, U Enemark, P Aaby, C S Benn, U K Griffiths
OBJECTIVES: Children younger than 12 months of age are eligible for childhood vaccines through the public health system in Guinea-Bissau. To limit open vial wastage, a restrictive vial opening policy has been implemented; 10-dose measles vaccine vials are only opened if six or more children aged 9-11 months are present at the vaccination post. Consequently, mothers who bring their child for measles vaccination can be told to return another day. We aimed to describe the household experience and estimate household costs of seeking measles vaccination in rural Guinea-Bissau...
October 7, 2016: Tropical Medicine & International Health: TM & IH
Stephen Gichuhi, Ephantus Macharia, Joy Kabiru, Alain M'bongo Zindamoyen, Hillary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, Timothy Onyuma, Walter G Jaoko, Mandeep S Sagoo, Helen A Weiss, Matthew J Burton
OBJECTIVE: To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls. METHODS: Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CI)...
October 7, 2016: Tropical Medicine & International Health: TM & IH
D Maman, J Ben-Farhat, B Chilima, C Masiku, L Salumu, N Ford, P Mendiharat, E Szumilin, S Masson, J F Etard
OBJECTIVE: HIV diagnosis and linkage to care are the main barriers in Africa to achieving the UNAIDS 90-90-90 targets. We assessed HIV-positive status awareness and linkage to care among survey participants in Chiradzulu District, Malawi. METHOD: Nested cohort study within a population-based survey of persons aged 15-59 years between February and May 2013. Participants were interviewed and tested for HIV (and CD4 if found HIV-positive) in their homes. Multivariable regression was used to determine factors associated with HIV-positive status awareness prior to the survey and subsequent linkage to care...
October 7, 2016: Tropical Medicine & International Health: TM & IH
Luz M Rodeles, Miguel H Vicco, Iván A Bontempi, Alvaro Siano, Georgina Tonarelli, Oscar A Bottasso, Pablo Arias, Iván S Marcipar
OBJECTIVE: Autoantibodies cross-reacting with the β1 adrenergic receptor (anti-β1AR and anti-p2β) and cardiac myosin antigens (anti-B13), have been related to the pathogenesis of chronic Chagas heart disease (CCHD). Studies exploring their levels in different stages are scarce. We aimed to evaluate the relationship of these autoantibodies with the clinical profile of chronic patients, especially regarding their classificatory accuracy in severe presentation with heart failure. METHODS AND RESULTS: We conducted a cross-sectional study of 155 T...
October 3, 2016: Tropical Medicine & International Health: TM & IH
José E Vidal, Carolina Toniolo, Adriana Paulino, Arnaldo Colombo, Marilena Dos Anjos Martins, Cristina da Silva Meira, Vera Lucia Pereira-Chioccola, Claudia Figueiredo-Mello, Tiago Barros, Jequelie Duarte, Fernanda Fonseca, Mirella Alves, Clara Mendes, Taiana Ribero, Marcia Dos Santos Lazera, Radha Rajasingham, David R Boulware
OBJECTIVE: To determine the prevalence of asymptomatic cryptococcal antigen (CRAG) using lateral flow assay (LFA) in hospitalized HIV-infected patients with CD4 counts < 200 cells/μL. METHODS: Hospitalized HIV-infected patients were prospectively recruited at Instituto de Infectologia Emilio Ribas, a tertiary referral hospital to HIV-infected patients serving the São Paulo State, Brazil. All patients were >18 years old without prior cryptococcal meningitis, without clinical suspicion of cryptococcal meningitis, regardless of antiretroviral (ART)-status, and with CD4 counts <200 cells/μL...
October 3, 2016: Tropical Medicine & International Health: TM & IH
Marcelo Araújo de Freitas, Angélica Espinosa Miranda, Ana Roberta Pati Pascom, Silvano Barbosa de Oliveira, Fabio Mesquita, Nathan Ford
OBJECTIVE: To describe the antiretroviral therapy status of people living with HIV (PLHIV) who died of AIDS-related causes between 2009 and 2013. METHODS: We conducted a cross-sectional, population-based study. Data were obtained by linking the mortality information system and the national ART dispensing database. Trends were modelled using linear regression analysis. RESULTS: A total of 61 425 AIDS-related deaths were registered in Brazil between 2009 and 2013...
October 3, 2016: Tropical Medicine & International Health: TM & IH
Clara Pons-Duran, Raquel González, Llorenç Quintó, Khatia Munguambe, Joan Tallada, Denise Naniche, Charfudin Sacoor, Elisa Sicuri
OBJECTIVES: To analyse the association between socioeconomic status (SES) and HIV in Manhiça, a district of Southern Mozambique with one of the highest HIV prevalences in the world. METHODS: Data were gathered from two cross-sectional surveys performed in 2010 and 2012 among 1511 adults and from the household census of the district's population. Fractional polynomial logit models were used to analyze the association between HIV and SES, controlling for age and sex and taking into account the non-linearity of covariates...
October 1, 2016: Tropical Medicine & International Health: TM & IH
Joshua Amo-Adjei, Derek Anamaale Tuoyire
OBJECTIVES: We analysed the extent of planned, mistimed and unwanted pregnancies and how they predict optimal use of prenatal (timing and number of antenatal) care services in 30 African countries. METHODS: We pooled data from Demographic and Health Surveys conducted in 30 African countries between 2006 and 2015. We described the extent of mistimed and unwanted pregnancies and further used mixed effects logistic and Poisson regression estimation techniques to examine the impacts of planned, mistimed and unwanted pregnancies on the use of prenatal health services...
September 27, 2016: Tropical Medicine & International Health: TM & IH
Selorme Adukpo, Ben A Gyan, Michael F Ofori, Daniel Dodoo, Thirumalaisamy P Velavan, Christian G Meyer
BACKGROUND: Malaria elicits inflammatory responses, which, if not well regulated, may exert detrimental effects. When activated, triggering receptor expressed on myeloid cells (TREM)-1 enhances inflammatory responses by increasing secretion of IL-8 and other Th1 cytokines. In contrast, TREM-like transcript 1 (TREML-1) promotes anti-inflammatory responses by binding to TREM-1 ligands and competing with TREM-1, thus antagonizing TREM-1 activation to reduce inflammation. Endothelial protein C receptor (EPCR) also mediates anti-inflammatory responses by activating endothelial protein C (PC)...
September 27, 2016: Tropical Medicine & International Health: TM & IH
Mandingha Kosso Etoka-Beka, Francine Ntoumi, Michael Kombo, Julia Deibert, Pierre Poulain, Christevy Vouvoungui, Simon Charles Kobawila, Felix Koukouikila-Koussounda
OBJECTIVES: To investigate the proportion of malaria infection in febrile children consulting a paediatric hospital in Brazzaville, to determine the prevalence of submicroscopic malaria infection, to characterise Plasmodium falciparum infection and compare the prevalence of uncomplicated P. falciparum malaria according to haemoglobin profiles. METHODS: Blood samples were collected from children aged <10 years with an axillary temperature ≥37.5 °C consulting the paediatric ward of Marien Ngouabi Hospital in Brazzaville...
September 27, 2016: Tropical Medicine & International Health: TM & IH
Andrew Lofts Gray, Yared Santa-Ana-Tellez, Veronika J Wirtz
OBJECTIVE: To assess the impact of mandatory offer of generic substitution, introduced in South Africa in May 2003, on private sector sales of generic and originator medicines for chronic diseases. METHODS: Private sector sales data (June 2001 to May 2005) were obtained from IMS Health for proton pump inhibitors (PPIs; ATC code A02BC), HMG-CoA reductase inhibitors (statins; C10AA), dihydropyridine calcium antagonists (C08CA), angiotensin-converting enzyme inhibitors (ACE-I; C09AA) and selective serotonin reuptake inhibitors (SSRIs; N06AB)...
September 27, 2016: Tropical Medicine & International Health: TM & IH
Raffaella Ravinetto, Anja De Weggheleire, Thomas P C Dorlo, Sven Francque, An Sokkab, Corinne Pouget, Bruno Meessen, Patricia Tabernero, Paul N Newton, Lut Lynen
No abstract text is available yet for this article.
September 27, 2016: Tropical Medicine & International Health: TM & IH
Kelly B Kamm, Jelena Vujcic, Sharifa Nasreen, Stephen P Luby, K Zaman, Shams El Arifeen, Pavani K Ram
OBJECTIVE: Promoting handwashing with soap to mothers of young children can significantly reduce diarrhoea and pneumonia morbidity among children, but studies that measured long-term behaviour after interventions rarely found improvements in handwashing habits. Expecting mothers may experience emotional and social changes that create a unique environment that may encourage adoption of improved handwashing habits. The objective of this study was to determine whether exposure to an intensive handwashing intervention in the perinatal period (perinatal arm) was associated with improved maternal handwashing behaviour vs...
September 19, 2016: Tropical Medicine & International Health: TM & IH
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