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Tropical Medicine & International Health: TM & IH

Meng-Die Wang, Yong Wang, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Zu-Xun Lu, Xiao-Xv Yin, Bo Hu
OBJECTIVES: A good mastery of stroke-related knowledge can be of great benefit in developing healthy behaviors. This study surveyed the knowledge about stroke and influencing factors among patients with acute ischemic stroke at discharge in a Chinese province. METHODS: A cross-section study was conducted from November 1, 2014 to January 31, 2015. A total of 1,531 acute ischemic stroke patients in Hubei Province completed a questionnaire at discharge. Multivariate linear regression was used to identify the influencing factors of their knowledge of stroke...
September 3, 2018: Tropical Medicine & International Health: TM & IH
Mabel Carabali, Jacqueline K Lim, Diana C Palencia, Anyela Lozano-Parra, Rosa Margarita Gelvez, Kang Sung Lee, Janeth P Florez, Victor Mauricio Herrera, Jay S Kaufman, Elsa M Rojas, Luis Angel Villar
OBJECTIVE: To estimate the age-specific incidence of symptomatic dengue and chikungunya in Colombia. METHOD: A passive facility-based fever surveillance study was conducted among individuals with undifferentiated fever. Confirmatory diagnostics included serological and molecular tests in paired samples, and surveillance's underreporting was assessed using capture-recapture methods. RESULTS: Of 839 febrile participants 686 completed the study...
September 3, 2018: Tropical Medicine & International Health: TM & IH
Geoffrey Jobson, Joshua Murphy, Mea van Huyssteen, Hanlie Myburgh, Theunis Hurter, Cornelis J Grobbelaar, Helen E Struthers, James A McIntyre, Remco P H Peters
OBJECTIVE: To evaluate how electronic data management systems affect data use practices in ART programs within local health districts, and individual health facilities. METHODS: We used a data quality audit to establish a baseline of the quality of data in the electronic register alongside in-depth interviews with health workers and managers, to understand perceptions of data quality, data use by facility staff and challenges affecting data use. RESULTS: The findings provide a 4-level continuum of data use that can be applied to other settings and recommendations for optimising facility level data use...
September 3, 2018: Tropical Medicine & International Health: TM & IH
Janne Estill, Kimberly Marsh, Christine Autenrith, Nathan Ford
OBJECTIVES: The 90-90-90 target states that by 2020, 90% of people living with HIV should be diagnosed, 90% of those diagnosed treated, and 90% of those treated virally suppressed. We assessed the actions needed in each country of sub-Saharan Africa to achieve the 90-90-90 target. METHODS: We developed a mathematical model to assess the number of patients needing to start ART between 2017 and 2020 to achieve 81% coverage by 2020 in each country, and the proportion of treated patients who are virally suppressed in four scenarios, combining two scenarios of retention (current-level or perfect), and routine viral load monitoring (current or universal coverage)...
August 29, 2018: Tropical Medicine & International Health: TM & IH
João Carlos Lopes Santos Filho, Marcelo Carvalho Vieira, Isis Gabrielli Gomes Xavier, Erica Rodrigues Maciel, Luiz Fernando Rodrigues Junior, Eduardo de Oliveira Vaz Curvo, Iane Miguel Pereira, Marcel de Souza Borges Quintana, Gilberto Marcelo Sperandio da Silva, Henrique Horta Veloso, Fernanda de Souza Nogueira Sardinha Mendes, Alejandro Marcel Hasslocher-Moreno, Andrea Silvestre de Sousa, Pedro Emmanuel Alvarenga Americano do Brasil, Roberto Magalhães Saraiva, Mauro Felippe Felix Mediano
OBJECTIVES: To evaluate the quality of life (QoL) of patients with Chagas disease (CD) and the association between QoL domains and several clinical, socioeconomic and lifestyle characteristics of this population. METHODS: Cross-sectional observational study conducted from March 2014 to March 2017 including a total of 361 outpatients followed at Evandro Chagas National Institute of Infectious Disease, Brazil. QoL was assessed using the Portuguese shorter version of the original WHO Quality of Life questionnaire (WHOQOL-BREF)...
August 29, 2018: Tropical Medicine & International Health: TM & IH
A Srividya, S Subramanian, C Sadanandane, V Vasuki, P Jambulingam
OBJECTIVES: Lymphatic filariasis (LF) elimination through mass drug administration (MDA) of DEC and albendazole have resulted in very low levels of infection in most endemic districts in India. But small pockets with residual microfilaraemia in the community and antigeneamia in children ('hotspots') are a cause of concern. We aimed to identify the determinants of such transmission hotspots and filarial infection in households using data from 33 communities. METHODS: The filariasis vector Culex quinquefasciatus was collected from 627 randomly selected households using gravid traps...
August 27, 2018: Tropical Medicine & International Health: TM & IH
Maeve Hume-Nixon, Hannah Kuper
OBJECTIVE: The aim of this study was to evaluate the association between childhood disability and malnutrition in low- and middle- income countries (LMICs). METHODS: Articles were identified from 1990 to August 2017 by searching nine electronic databases. Epidemiological studies, undertaken in LMICs that compared the prevalence of malnutrition in children with disabilities to children without disabilities were eligible for inclusion. Titles, abstracts, and full texts were screened by two reviewers, and data were extracted using a structured table for eligible papers...
August 27, 2018: Tropical Medicine & International Health: TM & IH
Milena Camargo, Luisa Del Río-Ospina, Sara Cecilia Soto-De León, Ricardo Sánchez, Andrea Clemencia Pineda-Peña, Otto Sussmann, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
OBJECTIVES: To identify the clinical and demographic characteristics of HIV-positive and HIV-negative women infected by multiple HPV types. METHODS: 1399 women participated in the study (240 HIV-positive and 1159 HIV-negative women). Samples were provided for Pap tests and for HPV detection and typing by PCR. Data were collected on HPV infection, frequency of multiple infection, and HPV type distribution. Odds ratios were reported from logistic regression models...
August 22, 2018: Tropical Medicine & International Health: TM & IH
Shah Mohammad Fahim, Subhasish Das, Md Amran Gazi, Mustafa Mahfuz, Tahmeed Ahmed
OBJECTIVE: Environmental Enteric Dysfunction (EED) can be assessed by faecal biomarkers such as Myeloperoxidase (MPO), Neopterin (NEO) and Alpha-1 anti-trypsin (AAT). We aimed to test the association of intestinal pathogens with faecal markers of EED among slum-dwelling children in first 2 years of life. METHODS: The MAL-ED birth cohort data of Bangladesh site were used to conduct this analysis. Multivariable analyses using Generalized Estimating Equations (GEE) were performed to test the association between intestinal pathogens and faecal markers of EED...
August 22, 2018: Tropical Medicine & International Health: TM & IH
Jean-Louis Koulidiati, Manuela De Allegri, Aurelia Souares, Samiratou Ouedraogo, Hervé Hien, Paul Jacob Robyn, Stephan Brenner
OBJECTIVE: To identify factors associated with both crude and effective health service coverage of under-fives in rural Burkina Faso. METHODS: In a cross-sectional study, 494 first-line health facilities, 7347 households and 12 497 under-fives were surveyed. Two sequential logistic random effects models were conducted to assess factors associated with crude and effective coverage. RESULTS: Of 614 children under-five with a reported illness episode, 427 (69...
August 17, 2018: Tropical Medicine & International Health: TM & IH
Rob Baltussen, Maarten Jansen, Leon Bijlmakers
No abstract text is available yet for this article.
August 15, 2018: Tropical Medicine & International Health: TM & IH
Nanny N M Soetedjo, Susan M McAllister, Cesar Ugarte-Gil, Adela G Firanescu, Katharina Ronacher, Bachti Alisjahbana, Anca L Costache, Carlos Zubiate, Stephanus T Malherbe, Raspati C Koesoemadinata, Yoko V Laurence, Fiona Pearson, Sarah Kerry-Barnard, Rovina Ruslami, David A J Moore, Mihai Ioana, Leanie Kleynhans, Hikmat Pernama, Philip C Hill, Maria Mota, Gerhard Walzl, Hazel M Dockrell, Julia A Critchley, Reinout van Crevel
OBJECTIVE: To describe the characteristics and management of Diabetes mellitus (DM) patients from low- and middle-income countries (LMIC). METHODS: We systematically characterized consecutive DM patients attending public health services in urban settings in Indonesia, Peru, Romania and South Africa, collecting data on DM treatment history, complications, drug treatment, obesity, HbA1c, and cardiovascular risk profile; and assessing treatment gaps against relevant national guidelines...
August 14, 2018: Tropical Medicine & International Health: TM & IH
Ditte Steiniche, Sanne Jespersen, Candida Medina, Fatima Corona Sanha, Christian Wejse, Bo Langhoff Hønge
OBJECTIVES: To estimate the magnitude of mortality and loss to follow-up and describe predictors of mortality among HIV-infected children in Guinea-Bissau. METHODS: Retrospective follow-up study among HIV-infected children under 15 years of age at the largest HIV-clinic in Guinea-Bissau from 2006-2016. A multivariate Cox proportional hazards model was used to identify predictors of mortality. RESULTS: Of 525 children were included in the analysis: 371 (70...
August 12, 2018: Tropical Medicine & International Health: TM & IH
Sabine L van Elsland, Remco P H Peters, Maarten O Kok, Ronald van Toorn, Priscilla Springer, Mark F Cotton, Cornelis J Grobbelaar, Rob Aarnoutse, A Marceline van Furth
OBJECTIVES: To evaluate a paediatric treatment-support intervention for home-based treatment of HIV infection or tuberculous meningitis (TBM). METHODS: A randomised-controlled study comparing local standard care (controls) with standard care plus intervention (combining adherence education, reinforcement and monitoring) in children aged 0-14 years. We recorded adherence measures (self-report, pill-count, drug-assays for isoniazid and rifampicin in urine and pyrazinamide in saliva), difficulties administering medication and PedsQL™questionnaires for health-related quality-of-life (HRQoL) and family impact...
August 3, 2018: Tropical Medicine & International Health: TM & IH
J Gajewski, L Bijlmakers, G Mwapasa, E Borgstein, C Pittalis, R Brugha
OBJECTIVES: Surgical services at district level in Malawi are poor, yet the majority of the population resides in rural areas. This study aimed to explore the perceived obstacles to surgery from the perspective of the cadre directly responsible for surgical service delivery at district hospitals. METHODS: Qualitative interviews were conducted with 16 clinical officers (COs) receiving surgical training in eight public district hospitals and their 12 trainers. Thematic analysis of data was conducted using a top-down coding method...
August 3, 2018: Tropical Medicine & International Health: TM & IH
Shintaro Hayashi, Daniel Chandramohan
OBJECTIVE: To assess the risk of active TB in people with DM and the factors associated with this risk. METHODS: Systematic review and meta-analysis. We searched the literature for studies that reported the effect of DM on TB controlled for the effect of age. Studies that had not established the diagnosis of DM prior to detecting active TB were excluded. Study quality was assessed by Newcastle-Ottawa scale and we conducted a meta-analysis using random-effects models...
July 30, 2018: Tropical Medicine & International Health: TM & IH
Mariano Altamiranda-Saavedra, Ximena Porcasi, Carlos Marcelo Scavuzzo, Margarita M Correa
OBJECTIVE: To map at a fine spatial scale, the risk of malaria incidence for the important endemic region is Urabá-Bajo Cauca and Alto Sinú, NW Colombia, using a new modelling framework based on GIS and remotely sensed environmental data. METHODS: The association between environmental and topographic variables obtained from remote sensors and the annual parasite incidence (API) for the years 2013-2015 was calculated using multiple regression analysis; subsequently, a model was constructed to estimate the API and to project it to the entire endemic region in order to design the risk map...
July 30, 2018: Tropical Medicine & International Health: TM & IH
Fabien Fily, E Ayikobua, D Ssemwanga, S Nicholas, P Kaleebu, C Delaugerre, E Pasquier, I Amoros Quiles, S Balkan, B Schramm
OBJECTIVES: The number of patients on second-line antiretroviral therapy is growing, but data on HIV drug resistance patterns at failure in resource-constrained settings are scarce. We aimed to describe drug resistance and investigate the factors associated with extensive resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTI), in patients failing second-line therapy in the HIV outpatient clinic at Arua Regional Referral Hospital, Uganda. METHODS: We included patients who failed on second-line therapy (two consecutive viral loads ≥1000 copies/mm3 by SAMBA-1 point-of-care test) and who had a drug resistance test performed between September 2014 and March 2017...
July 29, 2018: Tropical Medicine & International Health: TM & IH
Zhitong Zhang, Bryony Dawkins, Joseph P Hicks, John D Walley, Claire Hulme, Helen Elsey, Simin Deng, Mei Lin, Jun Zeng, Xiaolin Wei
BACKGROUND: We developed a multifaceted intervention to reduce antibiotic prescription rate for children with upper respiratory tract infections (URTIs) among primary care doctors in township hospitals in China. The intervention achieved a 29% (95% CI 16-42) absolute risk reduction in antibiotic prescribing. This study was to assess the cost-effectiveness of our intervention at reducing antibiotic prescribing in rural primary care facilities as measured by the intervention's effect on the antibiotic prescription rates for childhood URTIs...
July 29, 2018: Tropical Medicine & International Health: TM & IH
Pierre-Julien Coulaud, Luis Sagaon-Teyssier, Bakridine M'madi Mrenda, Gwenaëlle Maradan, Marion Mora, Michel Bourrelly, Bintou Dembélé Keita, Abdoul Aziz Keita, Camille Anoma, Stéphane-Alain Babo Yoro, Ter Tiero Elias Dah, Christian Coulibaly, Ephrem Mensah, Selom Agbomadji, Adeline Bernier, Clotilde Couderc, Christian Laurent, Bruno Spire
OBJECTIVE: To explore the interest in taking PrEP among Western African men who have sex with men (MSM). METHODS: A cross-sectional survey was implemented at enrolment of HIV-negative MSM in a multiple centre community-based cohort study in four West African countries (Mali, Côte d'Ivoire, Burkina Faso, Togo). A standardised face-to-face questionnaire collected data on socio-demographic and behavioural characteristics over the previous 6 months. Descriptive analysis and multivariate logistic regression helped identify factors associated with the interest in taking PrEP...
July 28, 2018: Tropical Medicine & International Health: TM & IH
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