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Transplantation

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https://www.readbyqxmd.com/read/28538499/expectations-and-experiences-of-follow-up-and-self-care-after-living-kidney-donation-a-focus-group-study
#1
Karine E Manera, Camilla S Hanson, Jeremy R Chapman, John Kanellis, John Gill, Jonathan C Craig, Steve J Chadban, Germaine Wong, Angelique F Ralph, Allison Tong
BACKGROUND: Ensuring donor wellbeing warrants ongoing monitoring following living kidney donation. However, there is considerable variability in donor follow up processes, including information provided to donors regarding self-care. Loss to follow up is common, suggesting that the aims and benefits of monitoring and follow up may not be apparent. We aimed to describe the experiences and expectations of living kidney donors regarding follow up and self-care after donation. METHODS: Participants from 3 transplant centers in Australia and Canada participated in 14 focus groups (n=123)...
May 24, 2017: Transplantation
https://www.readbyqxmd.com/read/28538498/ghrelin-protects-the-thymic-epithelium-from-conditioning-regimen-induced-damage-and-promotes-the-restoration-of-cd4-t-cells-in-mice-after-bone-marrow-transplantation
#2
Jingxia Xu, Junyu S Zhu, Xianyu Tian, Qixin Sun, Jianhui Xu, Yuxian Huang, Yingzhi He, Zhiwei Huang, Bingyi Wu
BACKGROUND: The delay in immune reconstitution after hematopoietic stem cell transplantation (HSCT), especially a delay in central immune reconstitution, leads to opportunistic infections and disease relapse after transplantation and affects the long-term outcome of HSCT. This delay is mainly attributable to thymic damage after myeloablative chemotherapy and radiotherapy METHODS: We established a model of allogeneic bone marrow transplantation (BMT) in mice and administered ghrelin (GRL) 7 days before the conditioning regimen or the day after BMT...
May 24, 2017: Transplantation
https://www.readbyqxmd.com/read/28538497/centenarian-livers-very-long-term-outcomes-of-very-old-grafts
#3
Mauro Salizzoni, Antonio Amoroso, Francesco Lupo, Renato Romagnoli
No abstract text is available yet for this article.
May 24, 2017: Transplantation
https://www.readbyqxmd.com/read/28538050/molecular-imaging-of-acute-cardiac-transplant-rejection-animal-experiments-and-prospects
#4
Yihan Chen, Li Zhang, Jinfeng Liu, Pingyu Zhang, Xiaoyuan Chen, Mingxing Xie
Acute rejection (AR) remains the biggest challenge during the 1st year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the gold standard for AR, endomyocardial biopsy has several limitations because of its inherent invasiveness and morbidity. Traditional imaging techniques such as echocardiography and cardiac magnetic resonance imaging are of certain value for AR, but their diagnostic criteria and accuracy remain in question...
May 19, 2017: Transplantation
https://www.readbyqxmd.com/read/28520579/the-use-of-an-acellular-oxygen-carrier-in-a-human-liver-model-of-normothermic-machine-perfusion
#5
Richard W Laing, Ricky H Bhogal, Lorraine Wallace, Yuri Boteon, Desley A H Neil, Amanda Smith, Barney T F Stephenson, Andrea Schlegel, Stefan G Hübscher, Darius F Mirza, Simon C Afford, Hynek Mergental
BACKGROUND: Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts under near-physiological conditions whilst maintaining their normal metabolic activity. This process requires an adequate oxygen supply, typically delivered by packed red blood cells (RBC). We present the first experience using an acellular hemoglobin-based oxygen carrier (HBOC) Hemopure in a human model of NMP-L. METHODS: Five discarded high-risk human livers were perfused with HBOC-based perfusion fluid and matched to 5 RBC-perfused livers...
May 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28514251/hepatic-hemodynamics-and-portal-flow-modulation-the-a2all-experience
#6
Jean C Emond, Nathan P Goodrich, James J Pomposelli, Talia B Baker, Abhinav Humar, David R Grant, Peter Abt, Chris E Friese, Robert A Fisher, Igal Kam, Averell H Sherker, Brenda W Gillespie, Robert M Merion
OBJECTIVE: A principal aim of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study was to study hepatic blood flow and effect of portal flow modulation on graft outcomes in the setting of increasing use of smaller and left lobe grafts. METHODS: Recipients of 274 living donor liver transplant were enrolled in A2ALL-2, including 233 (85.0%) right lobes, 40 (14.6%) left lobes, and 1 (0.5%) left lateral section. Hepatic hemodynamics were recorded after reperfusion...
May 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28514250/accept-or-decline-an-analytics-based-decision-tool-for-kidney-offer-evaluation
#7
Dimitris Bertsimas, Jerry Kung, Nikolaos Trichakis, David Wojciechowski, Parsia A Vagefi
BACKGROUND: When a deceased-donor kidney is offered to a waitlisted candidate, the decision to accept or decline the organ relies primarily upon a practitioner's experience and intuition. Such decisions must achieve a delicate balance between estimating the immediate benefit of transplantation and the potential for future higher-quality offers. However, the current experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague anecdotal decision-making...
May 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28514249/heart-transplantation-from-dcd-donors-from-the-bedside-to-the-bench
#8
Peter Macdonald
No abstract text is available yet for this article.
May 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28505026/combined-heart-lung-transplantation-an-updated-review-of-the-current-literature
#9
Shravani Pasupneti, Gundeep Dhillon, Bruce Reitz, Kiran Khush
Heart lung transplantation is a viable treatment option for patients with many end stage heart and lung pathologies. However, given the complex nature of the procedure, it is imperative that patients are selected appropriately and the clinician is aware of the many unique aspects in management of this population. This review seeks to describe updated organ selection policies, peri and postoperative management strategies, monitoring of graft function, and clinical outcomes for patients following combined heart-lung transplantation in the current era...
May 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28505025/a-rodent-model-of-cardiac-donation-after-circulatory-death-and-novel-biomarkers-of-cardiac-viability-during-ex-vivo-heart-perfusion
#10
Mark J Kearns, Sally Miller, Anson Cheung, Jamil Bashir, Stephanie Wong, Michael A Seidman, John H Boyd
BACKGROUND: Organ donation after circulatory death (DCD) is increasingly being used as a means of addressing the organ supply/demand mismatch in solid organ transplantation. There is reluctance to use DCD hearts, due to an inability to precisely identify hearts that have suffered irreversible injury. We investigated novel biomarkers and clinically relevant endpoints across a spectrum of warm ischemic times (WITs), prior to and during ex vivo heart perfusion (EVHP), to identify features associated with a non-viable cardiac phenotype...
May 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28505024/autonomic-nervous-system-pretransplant-malfunction-is-a-powerful-predictor-of-survival-after-allogeneic-hematopoietic-cell-transplantation
#11
Takahiko Nakane, Mika Nakamae, Hideo Koh, Mitsutaka Nishimoto, Yasuhiro Nakashima, Asao Hirose, Masayuki Hino, Hirohisa Nakamae
BACKGROUND: Autonomic nervous system function indexed by heart rate variability (HRV) has shown prognostic value for mortality in various cardiovascular and noncardiovascular diseases including cancer. The purpose of this study was to evaluate an association between HRV and outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) METHODS: We prospectively measured HRV as a surrogate pretransplant marker of autonomic nervous system activity in consecutive allo-HCTs with hematological diseases...
May 13, 2017: Transplantation
https://www.readbyqxmd.com/read/28471873/bladder-rupture-after-chronic-hemorrhagic-cystitis-in-a-stem-cell-transplantation-recipient
#12
Osamu Imataki, Shumpei Uchida, Yoshio Kushida, Makiko Uemura
No abstract text is available yet for this article.
May 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28471872/hla-matching-in-pediatric-kidney-transplantation-hla-poorly-matched-living-donor-transplants-versus-hla-well-matched-deceased-donor-transplants
#13
Gerhard Opelz, Bernd Döhler, Derek Middleton, Caner Süsal
BACKGROUND: Based on an analysis of 542 pediatric kidney transplants recorded by the UK Transplant Registry from 2000-2012, it was concluded that the survival rate of HLA poorly matched living donor transplants is not inferior to that of HLA well matched deceased donor transplants. METHODS: We analyzed the impact of HLA matching on kidney graft survival in 3627 pediatric living donor transplants performed during 2000-2015 using the data of the Collaborative Transplant Study...
May 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28471871/an-outcome-based-approach-to-assign-meld-exception-points-for-patients-with-hepatocellular-cancer
#14
Clark D Kensinger, Irene D Feurer, Seth J Karp
BACKGROUND: Current Model for End Stage Liver Disease (MELD) exception points provided to patients with hepatocellular cancer (HCC) are not based on outcome data and advantage these patients compared to those listed based on laboratory values (LABMELD). We sought to develop a data-based assignment for exception points for patients with HCC that equalizes outcomes among HCC and LABMELD patients. METHODS: We used Scientific Registry of Transplant Recipients data to compare patients listed with HCC who received exception points versus patients listed with LABMELD...
May 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28471870/the-effect-of-immunosuppression-on-airway-integrity
#15
Hannelore Bellon, Elly Vandermeulen, Stijn E Verleden, Tobias Heigl, Hanne Vriens, Elise Lammertyn, Lieve Verlinden, Thomas Vanhove, Mieke Verstuyf, Peter Hoet, Robin Vos, Geert M Verleden, Bart M Vanaudenaerde
BACKGROUND: Insults to the airway epithelium play a key role in constrictive bronchiolitis following lung transplantation (LTx), the typical hallmark of chronic rejection. Our hypothesis is that immunosuppressives might affect airway integrity. METHODS: A biculture of lung bronchial epithelial cells (16HBE) and lung microvascular endothelial cells (HLMVEC) was exposed to immunosuppressives (serum through levels) for 24h or 4 days. Cytotoxicity, trans-epithelial electrical resistance (TEER) and permeability was measured after exposure to monotherapies and combination therapies...
May 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28471889/authors-reply-nonalcoholic-fatty-liver-disease-portal-vein-thrombosis-and-coagulation-more-questions-than-answers
#16
Marwan Ghabril, Naga Chalasani
No abstract text is available yet for this article.
May 2, 2017: Transplantation
https://www.readbyqxmd.com/read/28471888/nonalcoholic-fatty-liver-disease-portal-vein-thrombosis-and-coagulation-more-questions-than-answers
#17
Jonathan G Stine, Nicolas Intagliata, Patrick G Northup, Stephen H Caldwell
No abstract text is available yet for this article.
May 2, 2017: Transplantation
https://www.readbyqxmd.com/read/28452923/mtor-inhibition-to-prevent-posttransplant-malignancies-don-t-stop-believin
#18
Philipp Renner
No abstract text is available yet for this article.
April 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28452922/chronic-amr-in-liver-transplant-validation-of-the-1-year-camr-score-s-ability-to-determine-long-term-outcome
#19
Jacqueline G O'Leary, Cory Smith, Juncao Cai, Brent Hart, Linda W Jennings, Matthew Everly, Goran B Klintmalm, Anthony J Demetris
BACKGROUND: A proposed chronic antibody-mediated rejection (AMR) score has recently predicted 50%10-year death censored allograft loss in patients with Donor Specific Alloantibodies (DSA) Mean Florescence Intensity (MFI) >10 000 and requires confirmation in patients with lower MFI (1000-10 000). METHODS: All patients who underwent liver transplantation (LT) from 1/00-4/09, had DSA (MFI ≥1000) in serum 10-14 months post-LT, and had a protocolized liver biopsy were evaluated (n=230)...
April 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28452921/targeting-circulating-leukocytes-and-pyroptosis-during-ex-vivo-lung-perfusion-improves-lung-preservation
#20
Kentaro Noda, Shinya Tane, Seok Jin Haam, Jonathan D'Cunha, Awori J Hayanga, James D Luketich, Norihisa Shigemura
BACKGROUND: The role of the circulating leukocytes in lungs and their relationship with circulating proinflammatory cytokines during ischemia-reperfusion injury is not well understood. Using ex vivo lung perfusion (EVLP) to investigate the pathophysiology of isolated lungs, we aimed to identify a therapeutic target to optimize lung preservation leading to successful lung transplantation. METHODS: Rat heart-lung blocks were placed on EVLP for 4 hours with or without a leukocyte-depleting filter (LF)...
April 27, 2017: Transplantation
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