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Transplantation

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https://www.readbyqxmd.com/read/29040170/kidney-transplantation-and-the-impact-on-health-related-quality-of-life-in-frail-patients
#1
Arika L Hoffman, Praise Matemavi
No abstract text is available yet for this article.
October 17, 2017: Transplantation
https://www.readbyqxmd.com/read/29019810/management-of-patients-who-receive-an-organ-transplant-abroad-and-return-home-for-follow-up-care-recommendations-from-the-declaration-of-istanbul-custodian-group
#2
Beatriz Domínguez-Gil, Gabriel Danovitch, Dominique E Martin, Marta López-Fraga, Kristof Van Assche, Michele L Morris, Jacob Lavee, Gilad Erlich, Riadh Fadhil, Mirela Busic, Glynn Rankin, Mona Al-Rukhaimi, Philip O Connell, Jacqueline Chin, Triona Norman, Pablo Massari, Refaat Kamel, Francis L Delmonico
Eradicating transplant tourism depends upon complex solutions that include efforts to progress towards self-sufficiency in transplantation. Meanwhile, professionals and authorities are faced with medical, legal, and ethical problems raised by patients who return home after receiving an organ transplant abroad, particularly when the organ has been obtained through illegitimate means. In 2016, the Declaration of Istanbul Custodian Group convened an international, multidisciplinary workshop in Madrid, Spain, to address these challenges and provide recommendations for the management of these patients, which are presented in this paper...
October 11, 2017: Transplantation
https://www.readbyqxmd.com/read/29019809/atrial-fibrillation-and-central-nervous-complications-in-liver-transplanted-hereditary-transthyretin-amyloidosis-patients
#3
Niklas Wange, Intissar Anan, Bo-Göran Ericzon, Johanna Pennlert, Björn Pilebro, Ole B Suhr, Jonas Wixner
BACKGROUND: Central nervous system (CNS) complications are increasingly noted in liver transplanted (LTx) hereditary transthyretin amyloid (ATTRm) amyloidosis patients; this suggests that the increased survival allows for intracranial ATTRm formation from brain synthesised mutant TTR. However, atrial fibrillation (AF), a recognised risk factor for ischemic CNS complications, is also observed after LTx. The aim of the study was to investigate the occurrence of CNS complications and AF in LTx ATTRm amyloidosis patients...
October 11, 2017: Transplantation
https://www.readbyqxmd.com/read/29019814/the-optimization-of-the-prevascularization-procedures-for-improving-subcutaneous-islet-engraftment
#4
Satomi Suzuki Uematsu, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Yasuhiro Igarashi, Ibrahim Fathi, Shigehito Miyagi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
BACKGROUND: Subcutaneous islet transplantation (SC Tx) is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Although the effectiveness of basic fibroblast growth factor (bFGF) was reported, the optimal procedures remain unclear. We sought to optimize the prevascularization procedures including the use of a novel scaffold, recombinant peptide (RCP). METHODS: Devices containing various amount of bFGF with/without heparin, or RCP were implanted into the subcutaneous space of diabetic C57BL/6 mice...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29019813/contemporary-policies-regarding-alcohol-and-marijuana-use-among-liver-transplant-programs-in-the-united-states
#5
Jiaming Zhu, Ping-Yu Chen, Marla Frankel, Robert R Selby, Tse-Ling Fong
BACKGROUND: Alcoholic liver disease is a common indication for liver transplantation (OLT). Although OLT has been shown to confer survival benefit to patients with acute alcoholic hepatitis (AAH), historically most programs require a 6-month abstinence period prior to OLT which excludes patients with AAH. Marijuana has become legal in more than half the states in the United States. This survey of liver transplant programs was conducted to evaluate current policies regarding alcohol, marijuana and methadone use...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29019812/venous-thromboembolism-after-adult-lung-transplantation-a-frequent-event-associated-with-lower-survival
#6
Manuel L Ribeiro Neto, Marie Budev, Daniel A Culver, C Randall Lane, Marcelo Gomes, Xiao-Feng Wang, Paulo Novis Rocha, Mitchell A Olman
BACKGROUND: The incidence of venous thromboembolism (VTE) after lung transplantation (LTX) varies significantly across studies. Two studies have suggested that these thrombotic events are associated with a lower posttransplant survival. Herein, we sought to determine the incidence, predictors and impact of VTE on survival after LTX at a quaternary referral center. METHODS: This was a large cohort study of LTX recipients. Key outcome parameters were time to VTE after transplant and survival...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29019811/rhesus-alloimunization-occurs-after-rh-incompatible-liver-transplantation-in-children
#7
Rishi Bolia, Sahana Shankar, Lauren Herd, Winita Hardikar
No abstract text is available yet for this article.
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/28991124/angiogenesis-in-the-transplanted-donor-graft-after-living-donor-liver-transplantation
#8
Dong-Hwan Jung, Sung-Hwan Moon, Soon-Jung Park, Eun Jae Kim, In Ho Jang, Cheon-Soo Park, Ji Yoon Lee, Yong-Pil Cho, Sung-Gyu Lee
BACKGROUND: There is no direct evidence for the role of angiogenesis in liver regeneration in humans. This study aimed to determine whether angiogenesis is involved in the regeneration of transplanted donor grafts in human living-donor liver transplantation (LDLT) and to examine the impact of donor graft volume on angiogenesis. METHODS: Clinical data and liver tissue characteristics were analyzed in 4 patients who received adult-to-adult LDLT with dual left lobe grafts from 2 living donors...
October 5, 2017: Transplantation
https://www.readbyqxmd.com/read/28976413/long-term-patient-and-graft-survival-of-kidney-transplant-recipients-with-hepatitis-c-virus-infection-in-the-united-states
#9
Nae-Yun Heo, Ajitha Mannalithara, Donghee Kim, Prowpanga Udompap, Jane C Tan, W Ray Kim
BACKGROUND: Hepatitis C virus (HCV) infection is common among kidney transplant (KTx) recipients. However, the impact of HCV infection on long-term graft and recipient survival after KTx from the large-scale data remains to be determined. METHODS: We used the Organ Procurement and Transplantation Network (OPTN) database to identify all adults undergoing KTx in 2004-2006 in the United States. A propensity score (PS) was created to match each HCV-positive recipient with a HCV-negative control for unbiased comparisons...
October 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28968355/role-of-human-cd200-overexpression-in-pig-to-human-xenogeneic-immune-response-compared-with-human-cd47-overexpression
#10
Ji-Jing Yan, Tai Yeon Koo, Han-Sin Lee, Wook-Bin Lee, Bohae Kang, Jae-Ghi Lee, Joon Young Jang, Taishi Fang, Jung-Hwa Ryu, Curie Ahn, Sung Joo Kim, Jaeseok Yang
BACKGROUND: Macrophages play important roles in xenograft rejection. Here, we investigated whether overexpression of human CD200 or CD47 in porcine endothelial cells (PEC) can suppress macrophages activation in xenogeneic immune responses. METHODS: PECs and human macrophages were incubated together, harvested and analyzed for in vitro macrophage phagocytic and cytotoxicity activity, and cytokine release. Next, PEC were injected into renal subcapsular space of humanized mice...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28968354/marked-decrease-in-urgent-listing-for-liver-transplantation-over-time-evolution-of-characteristics-and-outcomes-of-status-1-liver-transplantation
#11
Linda L Wong, Hung P Truong, Todd Seto, Lea Lacar, Willscott E Naugler
BACKGROUND: Approximately 5% of liver transplants annually are performed urgently with "status-1" designation. This study aims to determine if the demand, characteristics and outcome for status-1 liver transplantation has changed over time. METHODS: We utilized the Scientific Registry of Transplant Patients (2003-2015) to characterize 2352 adult patients who underwent 2408 status-1 liver transplants and compared them between Era1 (2003-6/2009) and Era2 (7/2009 -2015)...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28968353/long-term-effects-of-pancreas-transplantation-on-diabetic-retinopathy-and-incidence-and-predictive-risk-factors-for-early-worsening
#12
Yoon Jeon Kim, Sung Shin, Duck Jong Han, Young Hoon Kim, Joo Yong Lee, Young Hee Yoon, June-Gone Kim
BACKGROUND: Limited data are available regarding the long-term effects of pancreas transplantation on the progression of diabetic retinopathy (DR) and the incidence of and associated risk factors for early worsening of DR. METHODS: Patients who underwent successful pancreas transplantation between January 2007 and October 2015 and were followed for ≥ 1 year were consecutively enrolled. Variables regarding demographic, systemic, metabolic, and surgical factors were reviewed for each patient...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28968352/altered-th17-pathway-in-tolerant-kidney-transplant-patients-a-chicken-or-the-egg-dilemma
#13
I Esmé Dijke
No abstract text is available yet for this article.
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28968351/urinary-biomarker-cxcl10-identifying-site-specific-allograft-inflammation-in-renal-transplantation
#14
Roshan P George
No abstract text is available yet for this article.
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28968350/coexistence-of-bilirubin-%C3%A2-10-mg-dl-and-prothrombin-time-international-normalized-ratio-%C3%A2-1-6-on-day-7-a-strong-predictor-of-early-graft-loss-after-living-donor-liver-transplantation
#15
Yusuke Okamura, Shintaro Yagi, Toshiya Sato, Koichiro Hata, Eri Ogawa, Atsushi Yoshizawa, Naoko Kamo, Noriyo Yamashiki, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) ≥10 mg/dL or prothrombin time-international normalized ratio (PT-INR) ≥1.6 on postoperative day 7 (POD7) or aminotransferase >2000 IU/L within the first week, is associated with early graft loss after deceased-donor liver transplantation. We aimed to determine the prognostic impact of the EAD definition in living-donor liver transplantation (LDLT). METHODS: We analyzed the validity of the EAD definition and its impact on early graft survival in 260 adult recipients who underwent primary LDLT...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28957846/the-authors-reply
#16
Erlend Johannessen Egeland, Elisabet Størset, Ida Robertsen, Monica Hermann, Karsten Midtvedt, Marte Theie Gustavsen, Rolf Klaasen, Stein Bergan, Anders Hartmann, Anders Åsberg
No abstract text is available yet for this article.
September 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28957845/the-importance-in-using-serially-measured-tac-clearance-values-especially-during-the-early-posttransplant-period
#17
Jeffrey J Gaynor, Gaetano Ciancio
No abstract text is available yet for this article.
September 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28957844/human-metapneumovirus-infection-pneumonia-risk-factors-in-solid-organ-transplantation-patients-and-ct-findings
#18
Hyun Jung Koo, Han Na Lee, Sang Ho Choi, Heungsup Sung, Sang Young Oh, So Youn Shin, Hwa Jung Kim, Kyung-Hyun Do
BACKGROUND: Human metapneumovirus (HMPV) is a newly detected pathogen which can cause lower respiratory tract disease. Clinical characteristics, computed tomography (CT) findings, and outcomes of HMPV pneumonia in solid organ transplantation (SOT) patients have not been well demonstrated. METHODS: Between January 2010 and February 2016, clinical and imaging findings of 59 patients receiving SOT (types of organ: 37 kidney, 16 liver, 4 heart and 2 pancreas and kidney) who had HMPV infection detected in nasopharyngeal or bronchoalveolar lavage by reverse transcription polymerase chain reaction were retrospectively evaluated...
September 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28957843/chronic-liraglutide-administration-fails-to-suppress-postprandial-glucagon-levels-in-type-1-diabetic-islet-allograft-recipients-with-graft-dysfunction
#19
Francesco Vendrame, Nathalia Padilla, Eduardo Peixoto, David Baidal, Violet Lagari, Ana Alvarez Gil, Alejandro Mantero, Shari Messinger, Camillo Ricordi, Rodolfo Alejandro
No abstract text is available yet for this article.
September 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28938312/long-cold-ischemia-times-in-same-hospital-deceased-donor-transplants
#20
Eric Kh Chow, Sandra DiBrito, Xun Luo, Corey Wickliffe, Allan B Massie, Jayme E Locke, Sommer E Gentry, Jacqueline Garonzik-Wang, Dorry L Segev
BACKGROUND: Recent changes in deceased donor organ allocation for livers (Share-35) and kidneys (KAS) have resulted in broader sharing of organs and increased cold ischemia time (CIT). Broader organ sharing however is not the only cause of increased CIT. METHODS: This was a retrospective registry study of CIT in same-hospital liver transplants (SHLT, n=4,347) and kidney transplants (SHKT, n=9,707) between 2004 and 2014. RESULTS: In SHLT, median (IQR) CIT was 5...
September 20, 2017: Transplantation
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