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Transplantation

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https://www.readbyqxmd.com/read/29461440/ganja-no-barrier-for-liver-transplantation
#1
Willscott E Naugler, Susan L Orloff
No abstract text is available yet for this article.
February 15, 2018: Transplantation
https://www.readbyqxmd.com/read/29461442/3d-endoscopic-donor-nephrectomy-versus-robot-assisted-donor-nephrectomy-a-detailed-comparison-of-2-prospective-cohorts
#2
Evalyn E A P Mulder, Shiromani Janki, Türkan Terkivatan, Karel W J Klop, Jan N M IJzermans, T C Khe Tran
BACKGROUND: There are 2 endoscopic surgical techniques that implement 3D vision to overcome visual misperception: 3D endoscopy and the da Vinci surgical system. 3D endoscopy has several advantages, such as the presence of tactile feedback and easy implementation, at lower costs. We aimed to assess whether 3D endoscopy could be an alternative to the robot during living donor nephrectomy (LDN). METHODS: Between April 2015 and April 2016 we prospectively collected data on 40 patients undergoing 3D endoscopic LDNs in 1 center, performed by a da Vinci certified surgeon...
February 14, 2018: Transplantation
https://www.readbyqxmd.com/read/29461441/sensing-danger-after-kidney-transplantation
#3
Daniel Zecher
No abstract text is available yet for this article.
February 14, 2018: Transplantation
https://www.readbyqxmd.com/read/29443827/a-comparison-of-hla-molecular-mismatch-methods-to-determine-hla-immunogenicity
#4
C Wiebe, V Kosmoliaptsis, D Pochinco, C Taylor, P Nickerson
BACKGROUND: Antibody-mediated rejection is a major cause of premature graft loss in kidney transplantation. Multiple scoring systems are available to assess the HLA mismatch between donors and recipients at the molecular level, however, their correlation with the development of de novo donor-specific antibody (dnDSA) has not been compared in recipients on active immunosuppression. METHODS: HLA-DRβ1/3/4/5/DQα1β1 molecular mismatch was determined using eplet analysis, amino acid mismatch, and electrostatic mismatch for 596 renal transplant recipients and correlated with HLA-DR/DQ dnDSA development...
February 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29443826/higher-risk-of-posttransplant-graft-failure-in-male-recipients-of-female-donor-grafts-might-not-be-due-to-anastomotic-size-disparity
#5
Kyo Won Lee, Sangbin Han, Sanghoon Lee, Hyun-Hwa Cha, Soohyun Ahn, Hyeon Seon Ahn, Justin S Ko, Mi Sook Gwak, Gaab Soo Kim, Jae-Won Joh, Suk-Koo Lee, Gyu-Seong Choi
BACKGROUND: Posttransplant liver graft failure occurs most often in male recipients of livers from female donors. The respective role of donor sex itself and the size disparity in graft vessels/bile ducts according to donor sex are unclear. Thus, we aimed to evaluate the importance of donor sex with adjustment for anastomotic size disparity between female and male donor grafts. METHODS: A total of 309 male patients without hepatic tumors who underwent living donor liver transplantation were analyzed (109 female and 200 male donors)...
February 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29438141/single-antigen-bead-assays-to-define-unacceptable-antigen-mismatches
#6
Georg A Böhmig, Luis G Hidalgo
No abstract text is available yet for this article.
February 12, 2018: Transplantation
https://www.readbyqxmd.com/read/29424768/current-status-of-surgical-incisions-used-in-donors-during-living-related-liver-transplantation-a-nationwide-survey-in-japan
#7
Ken Shirabe, Susumu Eguchi, Hideaki Okajima, Kiyoshi Hasegawa, Shigeru Marubashi, Koji Umeshita, Seiji Kawasaki, Katsuhiko Yanaga, Mitsuo Shimada, Toshimi Kaido, Naoki Kawagishi, Akinobu Taketomi, Koichi Mizuta, Norihiro Kokudo, Shinji Uemoto, Yoshihiko Maehara
BACKGROUND: Smaller surgical incisions have recently been introduced in living donor liver procurement. This study used national data from Japan to clarify the present status of surgical incisions in living donor liver procurement. METHODS: A nationwide, questionnaire-based survey related to 3121 donors and recipients was used. Donors were divided into two groups: left lateral segment graft (LLSG) procurement (n=690) and other types (n=2431). Incisions were classified into six types: type I, upper midline and bilateral subcostal; type II, upper midline and right subcostal; type III: upper midline and right subcostal to the right lateral margin of the abdominal rectus muscle; type IV, upper midline without laparoscopy; type V, upper midline with laparoscopy; and type VI, lower abdominal using the full laparoscopic technique...
February 9, 2018: Transplantation
https://www.readbyqxmd.com/read/29424767/extracellular-vesicles-from-human-liver-stem-cells-reduce-injury-in-an-ex-vivo-normothermic-hypoxic-rat-liver-perfusion-model
#8
Federica Rigo, Nicola De Stefano, Victor Navarro-Tableros, Ezio David, Giorgia Rizza, Giorgia Catalano, Nicholas Gilbo, Francesca Maione, Federica Gonella, Dorotea Roggio, Silvia Martini, Damiano Patrono, Mauro Salizzoni, Giovanni Camussi, Renato Romagnoli
BACKGROUND: The gold standard for organ preservation before transplantation is static cold storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury. An emerging alternative is normothermic machine perfusion (NMP), which permits organ reconditioning. Here, we aimed to explore the feasibility of a pharmacological intervention on isolated rat livers by using a combination of NMP and human liver stem cells-derived extracellular vesicles (HLSC-EV). METHODS: We established an ex vivo murine model of NMP capable to maintain liver function despite an ongoing hypoxic injury induced by hemodilution...
February 9, 2018: Transplantation
https://www.readbyqxmd.com/read/29406445/protecting-donor-livers-during-normothermic-machine-perfusion-with-stem-cell-evs
#9
Ashish K Sharma, Victor E Laubach
No abstract text is available yet for this article.
February 5, 2018: Transplantation
https://www.readbyqxmd.com/read/29406444/brief-summary-report-from-the-14th-biennial-meeting-of-the-international-xenotransplantation-association
#10
Richard N Pierson
The fourteenth meeting of the International Xenotransplantation Association (IXA) 2017, was held at University of Maryland, Baltimore, between September 19th and 23rd, 2017. This monograph summarizes reported progress in the field.
February 5, 2018: Transplantation
https://www.readbyqxmd.com/read/29406443/extended-pancreas-donor-program-the-expand-study-a-prospective-multicenter-trial-testing-the-use-of-pancreas-donors-over-age-50
#11
Andrea Proneth, Andreas A Schnitzbauer, Peter Schenker, Andreas Wunsch, Falk Rauchfuss, Helmut Arbogast, Steffen Manekeller, Silvio Nadalin, Michael Heise, Michael A Ströhlein, Bernhard Banas, Peter Schemmer, Thomas Becker, Wolf O Bechstein, Andreas Pascher, Richard Viebahn, Edward K Geissler, Hans J Schlitt, Stefan A Farkas
BACKGROUND: Pancreas transplantation is the only curative treatment option for patients with juvenile diabetes. Organ shortage and restrictive allocation criteria are the main reasons for increasing waitlists leading to severe morbidity and mortality. We designed a study to increase the donor pool with extended donor criteria (EDC) organs (donor age 50-60 years or BMI 30-34kg/m). METHODS: Utilization of EDC organs required the implementation of a new allocation system within Eurotransplant...
February 5, 2018: Transplantation
https://www.readbyqxmd.com/read/29401123/outcome-of-portopulmonary-hypertension-after-liver-transplantation-perhaps-not-so-optimistic
#12
Laurent Savale, Jean-Charles Duclos-Vallée, Olivier Sitbon
No abstract text is available yet for this article.
February 2, 2018: Transplantation
https://www.readbyqxmd.com/read/29389767/outcomes-of-donation-after-cardiac-death-liver-grafts-from-donors-%C3%A2-50-years-of-age-a-multi-center-analysis
#13
Kristopher P Croome, Amit K Mathur, David D Lee, Adyr A Moss, Charles B Rosen, Julie K Heimbach, C Burcin Taner
INTRODUCTION: As the population in the United States continues to age, an increase in the number of potential DCD donors with advanced chronological age can be expected. The aim of this study was to analyze a multi-institutional experience in liver transplantation using DCD donor age ≥50 years. METHODS: All DCD LT performed at Mayo Clinic Florida, Mayo Clinic Rochester and Mayo Clinic Arizona from 2002-2016 were included. Recipients of DCD LT were divided into 2 groups: those with donor age ≥50 years(N=155) and those with donor age <50 years(N=316)...
January 31, 2018: Transplantation
https://www.readbyqxmd.com/read/29377877/incidence-of-cytomegalovirus-dnaemia-in-pediatric-kidney-transplant-recipients-after-cessation-of-antiviral-prophylaxis
#14
Thanaporn Chaiyapak, Karlota Borges, Angela Williams, Tonny Banh, Jovanka Vasilevska-Ristovska, Upton Allen, Rulan S Parekh, Diane Hébert
BACKGROUND: Late cytomegalovirus (CMV) infection can occur after cessation of viral prophylaxis in kidney transplant recipients, yet, timing of infection is unclear and longer duration of prophylaxis may be warranted. METHODS: We conducted a retrospective cohort study of 86 children (35 CMV donor seropositive, recipient seronegative [D+R-] and 51 CMV recipient seropositive [R+]) <18 years who received a kidney transplant between January 2002-June 2014 and were treated with antiviral prophylaxis for 3 months after transplantation...
January 26, 2018: Transplantation
https://www.readbyqxmd.com/read/29377876/gender-race-and-disease-etiology-predict-de-novo-malignancy-risk-following-liver-transplantation-insights-for-future-individualized-cancer-screening-guidance
#15
Mamatha Bhat, Kristin Mara, Ross Dierkhising, Kymberly D Watt
BACKGROUND: Malignancy after liver transplant (LT) is a leading cause of mortality, but data is limited. The aim of this study was to identify patients at higher risk for de novo malignancies after LT in a large multicenter database. METHODS: The Scientific Registry of Transplant Recipients database comprising all 108,412 liver transplant recipients across the U.S. between 1987 and March 2015 was analyzed with a median follow-up of 6.95 years. Potential risk factors for malignancies after LT were assessed using Cox regression analysis for the outcome of time to first malignancy...
January 26, 2018: Transplantation
https://www.readbyqxmd.com/read/29377875/novel-tof-ms-means-of-quantifying-apoai-amyloid-protein-load-following-combined-liver-kidney-transplantation
#16
Katherine G Richards, Stephen O Brennan, Geoffrey W McCaughan, Steven J Chadban
No abstract text is available yet for this article.
January 26, 2018: Transplantation
https://www.readbyqxmd.com/read/29377874/successful-sequential-liver-and-haematopoietic-stem-cell-transplantation-in-a-child-with-cd40-ligand-deficiency-and-cryptosporidium-induced-liver-cirrhosis
#17
Paola Quarello, Francesco Tandoi, Francesca Carraro, Elena Vassallo, Michele Pinon, Renato Romagnoli, Ezio David, Dominic Dell Olio, Mauro Salizzoni, Franca Fagioli, Pier Luigi Calvo
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is curative in patients with primary immunodeficiencies. However, pre-HSCT conditioning entails unacceptably high risks if the liver is compromised. The presence of a recurrent opportunistic infection affecting the biliary tree and determining liver cirrhosis with portal hypertension posed particular decisional difficulties in a seven-year-old child with X-linked CD40-ligand deficiency. We aim at adding to the scanty experience available on such rare cases, as successful management with sequential liver transplantation (LT) and HSCT has been reported in detail only in one young adult to date...
January 26, 2018: Transplantation
https://www.readbyqxmd.com/read/29369249/durable-clinical-and-immunologic-advantage-of-living-donor-liver-transplantation-in-children
#18
Eric M Przybyszewski, Elizabeth C Verna, Steven J Lobritto, Mercedes Martinez, Jennifer M Vittorio, Alyson N Fox, Benjamin Samstein, Tomoaki Kato, Adam D Griesemer, Jean C Emond
BACKGROUND: Despite high survival in pediatric living donor liver transplantation (LDLT), only 10% of liver transplants in children in the United States are from living donors, reflecting reluctance to embrace this approach. In addition to optimal timing and graft quality, LDLT may offer immunologic benefit since most donors are haplo-identical parents. We sought to quantify the benefit of LDLT compared to deceased donor liver transplantation (DDLT) using granular clinical and immunologic outcomes over the long-term...
January 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29360666/specific-donor-hla-dr-types-correlate-with-altered-susceptibility-to-development-of-chronic-lung-allograft-dysfunction
#19
Lynn D Haynes, Walker Julliard, Joshua Mezrich, Glen Leverson, Keith C Meyer, William J Burlingham
BACKGROUND: The greatest challenge to long-term graft survival is the development of chronic lung allograft dysfunction (CLAD). Th17 responses to collagen type V (colV) predispose lung transplant patients to the severe obstructive form of CLAD, known as bronchiolitis obliterans syndrome (BOS). In a previous study cohort (n=54), pre-transplant colV responses were increased in recipients expressing HLA-DR15, consistent with the high binding avidity of colV(α1) peptides for HLA-DR15, while BOS incidence, which was known to be strongly associated with post-transplant autoimmunity to colV, was higher in patients who themselves lacked HLA-DR15, but whose lung donor expressed it...
January 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29346262/important-facts-about-organ-donation-and-opo-performance
#20
David S Goldberg, Teresa Shafer, Laura Siminoff
No abstract text is available yet for this article.
January 18, 2018: Transplantation
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