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Transplantation

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https://www.readbyqxmd.com/read/29688998/persistent-alpha-galactosidase-a-deficiency-following-simultaneous-liver-kidney-transplantation-in-a-patient-with-fabry-disease
#1
Alisa Likhitsup, John H Helzberg, Laura M Alba, Meghan K Larkin, Lee S Cummings, Eddie R Island, Ryan M Lustig, Jameson Forster
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688997/successful-kidney-transplant-from-donor-with-carbon-monoxide-poisoning
#2
Eric Siskind, Johann Jonsson
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688996/advances-on-cd8-tregs-and-their-potential-in-transplantation
#3
Séverine Bézie, Ignacio Anegon, Carole Guillonneau
Although CD8 Tregs have been in the last 20 years more studied since evidences of their role in tolerance as been demonstrated in transplantation, autoimmune diseases and cancer, their characteristics are still controversial. In this review, we will focus on recent advances on CD8 Tregs and description of a role for CD8 Tregs in tolerance in both solid organ transplantation and GVHD and their potential for clinical trials.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688995/correlation-between-kidney-transplant-outcome-metrics-and-waitlist-metrics
#4
Sheng Zhou, Courtenay M Holscher, Allan B Massie, Dorry L Segev, Lauren Hersch Nicholas
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688994/generation-of-immunodeficient-rats-with-rag1-and-il2rg-gene-deletions-and-human-tissue-grafting-models
#5
Séverine Ménoret, Laure-Hélène Ouisse, Laurent Tesson, Frédéric Delbos, Delphine Garnier, Séverine Remy, Claire Usal, Jean-Paul Concordet, Carine Giovannangeli, Vanessa Chenouard, Lucas Brusselle, Emmanuel Merieau, Véronique Nerrière-Daguin, Franck Duteille, Frédérique Bellier-Waast, Alexandre Fraichard, Tuan H Nguyen, Ignacio Anegon
BACKGROUND: Immunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune responses. Nevertheless, there are models and experimental situations that would beneficiate of larger immunodeficient recipients. Rats are ideally suited to perform experiments in which larger size is needed and are still a small animal model suitable for rodent facilities. Additionally, rats reproduce certain human diseases better than mice, such as ankylosing spondylitis and Duchenne disease and these disease models would greatly benefit of immunodeficient rats to test different immunogenic treatments...
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688993/british-transplantation-society-renal-association-uk-guidelines-for-living-donor-kidney-transplantation-2018-summary-of-updated-guidance
#6
Peter A Andrews, Lisa Burnapp
No abstract text is available yet for this article.
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29688992/long-term-outcomes-of-kidney-transplantation-in-fabry-disease
#7
Sara Ersözlü, Robert J Desnick, Uyen Huynh-Do, Sima Canaan-Kühl, Frédéric Barbey, Vera Genitsch, Thomas Müller, Marcus Cheetham, Andreas Flammer, Stefan Schaub, Albina Nowak
BACKGROUND: Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A gene that obliterate or markedly reduce α-galactosidase A activity. This results in the systemic accumulation of its glycosphingolipid substrates in body fluids and organs, including the kidney. Fabry nephropathy can lead to end-stage renal disease requiring kidney transplantation. Little is known about its long-term outcomes and the overall patient survival after kidney transplantation...
April 23, 2018: Transplantation
https://www.readbyqxmd.com/read/29684002/how-should-social-media-be-used-in-transplantation-a-survey-of-the-american-society-of-transplant-surgeons
#8
Macey L Henderson, Joel T Adler, Sarah E Van Pilsum Rasmussen, Alvin G Thomas, Patrick D Herron, Madeleine M Waldram, Jessica M Ruck, Tanjala S Purnell, Sandra R DiBrito, Courtenay M Holscher, Christine E Haugen, Yewande Alimi, Jonathan M Konel, Ann K Eno, Jacqueline M Garonzik Wang, Elisa J Gordon, Krista L Lentine, Randolph L Schaffer, Andrew M Cameron, Dorry L Segev
BACKGROUND: Social media platforms are increasingly used in surgery and have shown promise as effective tools to promote deceased donation and expand living donor transplantation. There is growing need to understand how social media-driven communication is perceived by providers in the field of transplantation. METHODS: We surveyed 299 members of the American Society of Transplant Surgeons (ASTS) about their use of, attitudes toward, and perceptions of social media and analyzed relationships between responses and participant characteristics...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29684001/one-hundred-and-fifteen-cases-of-pure-laparoscopic-living-donor-right-hepatectomy-at-a-single-center
#9
Kwang-Woong Lee, Suk Kyun Hong, Kyung-Suk Suh, Hyo-Sin Kim, Sung-Woo Ahn, Kyung Chul Yoon, Jeong-Moo Lee, Jae-Hyung Cho, Hyeyoung Kim, Nam-Joon Yi
BACKGROUND: The pure laparoscopic approach to donor hepatectomy is being taken more often. However, few centers perform pure laparoscopic donor right hepatectomy (PLDRH) because it requires a high level of surgical skill. Studies reporting initial outcomes of PLDRH may prompt further implementation of the technique and help reduce initial learning curves at other transplant centers. This study reports performance of PLDRH at a single center with extensive experience of adult living donor liver transplantation...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29684000/split-liver-transplantation-and-pediatric-waitlist-mortality-in-the-united-states-potential-for-improvement
#10
Emily R Perito, Garrett Roll, Jennifer L Dodge, Sue Rhee, John P Roberts
BACKGROUND: In the United States, 1 in 10 infants and 1 in 20 older children die on the liver transplant waiting list. Increasing split liver transplantation could increase organ availability for these children, without decreasing transplants in adults. METHODS: Using UNOS STAR data, we identified livers transplanted 2010-2015 that could potentially have been used for split transplant, based on strict criteria. Livers not suitable for pediatric patients or allocated to high-risk recipients were excluded...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#11
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29683998/diagnosis-pathophysiology-and-experimental-models-of-chronic-lung-allograft-rejection
#12
Jason M Gauthier, Daniel Ruiz-Pérez, Wenjun Li, Ramsey R Hachem, Varun Puri, Andrew E Gelman, Daniel Kreisel
Chronic rejection is the Achilles' heel of modern lung transplantation, characterized by a slow, progressive decline in allograft function. Clinically, this manifests as obstructive disease, restrictive disease, or a mixture of the 2 depending on the underlying pathology. The 2 major phenotypes of chronic rejection include bronchiolitis obliterans syndrome and restrictive allograft syndrome. The last decade of research has revealed that each of these phenotypes has a unique underlying pathophysiology which may require a distinct treatment regimen for optimal control...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29677081/changes-in-pediatric-heart-transplant-hospitalization-costs-over-time
#13
Justin Godown, Cary Thurm, Matt Hall, Jonathan H Soslow, Brian Feingold, Bret A Mettler, Andrew H Smith, David W Bearl, Debra A Dodd
BACKGROUND: Despite significant changes in the past decade for children undergoing heart-transplantation, including the evolution of mechanical circulatory support and increasing patient complexity, costs and resource utilization have not been reassessed. We sought to utilize a novel linkage of clinical-registry and administrative data to examine changes in hospitalization costs over time in this population. METHODS: We identified all pediatric heart transplant recipients in a unique linked PHIS/SRTR dataset (2002-2016)...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#14
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677079/cytomegalovirus-a-guide-for-the-perplexed
#15
Carlos A Q Santos, Daniel C Brennan
No abstract text is available yet for this article.
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677078/therapeutic-outcomes-of-haploidentical-allogeneic-hematopoietic-stem-cell-transplantation-in-patients-with-severe-aplastic-anemia-a-multicenter-study
#16
Yonghua Li, Fengqi Duan, Haowen Xiao, Xiaoxiong Wu, Shunqing Wang, Duorong Xu, Qifa Liu, Zhiping Fan, Danian Nie, Yongrong Lai, Bingyi Wu, Dongjun Lin, Xin Du, Jianyu Weng, Xin Du, Zujun Jiang, Yan Pang, Lin Ouyang, Zenghui Liu, Leqin Zhang, Na Han, Lixuan Chen, Yang Xiao
BACKGROUND: Haploidentical donor allogeneic hematopoietic stem cell transplantation (HID-HSCT) is an alternative curative treatment for patients with severe aplastic anemia (SAA) who do not have suitable matched related donors (MRD). The aim of this study was to compare the therapeutic outcomes of HID-HSCT with those of MRD-HSCT for SAA. METHODS: A total of 235 SAA patients who underwent HID-HSCT (116) or MRD-HSCT (119) at 11 transplantation centers from January 2007 to January 2016 were included...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677077/measured-vs-estimated-glomerular-filtration-egfr-rate-in-the-assessment-of-living-kidney-donors-egfr-has-its-limitations
#17
Iain A M MacPhee
No abstract text is available yet for this article.
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677076/gearing-up-for-stem-cell-derived-beta-cells-are-we-ready
#18
A M James Shapiro
No abstract text is available yet for this article.
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677075/measured-glomerular-filtration-rate-after-kidney-donation-no-evidence-of-accelerated-decay
#19
Danielle M Berglund, Lei Zhang, Arthur J Matas, Hassan N Ibrahim
BACKGROUND: The rate of measured GFR change in kidney donors years after donation has not been adequately addressed. Whether this change is accelerated in the setting of 1 kidney is also understudied. METHODS: 214 randomly selected donors underwent serial GFR measurements of nonradioactive iohexol. eGFR at each visit was calculated using the CKD EPI and MDRD study equations. RESULTS: GFR visits were 4.8 ±1.3 years apart and the second occurring 16...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677074/frailty-inflammatory-markers-and-waitlist-mortality-among-patients-with-end-stage-renal-disease-in-a-prospective-cohort-study
#20
Mara A McAdams-DeMarco, Hao Ying, Alvin G Thomas, Fatima Warsame, Ashton A Shaffer, Christine E Haugen, Jacqueline M Garonzik-Wang, Niraj M Desai, Ravi Varadhan, Jeremy Walston, Silas P Norman, Dorry L Segev
BACKGROUND: Among community-dwelling older adults, frailty is associated with heightened markers of inflammation and subsequent mortality. Although frailty is common among ESRD patients, the role of frailty and markers of inflammation in this population remains unclear. We quantified these associations in patients on the kidney transplant (KT) waitlist and tested whether frailty and/or markers of inflammation improve waitlist mortality risk prediction. METHODS: We studied 1,975 ESRD patients on the KT waitlist (11/1/09-2/28/17) in a multi-center cohort study of frailty...
April 19, 2018: Transplantation
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