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Transplantation

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https://www.readbyqxmd.com/read/28437287/allocation-of-organs-should-be-based-on-the-current-status-of-medical-science
#1
Bruno Reichart, Ulrich Schroth, Karl-Walter Jauch
No abstract text is available yet for this article.
April 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28437286/cut-the-gordian-knot
#2
Guenter Kirste
No abstract text is available yet for this article.
April 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28422925/dynamics-of-b-cell-recovery-following-kidney-bone-marrow-transplant-recipients
#3
Baoshan Gao, Yiming Gu, Chunshu Rong, Carolina Moore, Fabrice Porcheray, Waichi Wong, Frederic Preffer, Susan L Saidman, Yaowen Fu, Benedict Cosimi, David H Sachs, Tatsuo Kawai, Megan Sykes, Emmanuel Zorn
BACKGROUND: Previous studies identified B cell gene signatures and predominance of specific B cell subsets as a marker of operational tolerance following kidney transplantation. These findings suggested a role for B cells in the establishment or maintenance of tolerance. Here we analyzed B cell recovery in 4 subjects, 3 of whom achieved tolerance after combined kidney/bone marrow transplantation. METHODS: Peripheral B cell subsets were examined longitudinally by flow cytometry...
April 19, 2017: Transplantation
https://www.readbyqxmd.com/read/28422926/targeting-high-calcineurin-inhibitor-levels-after-acute-rejection-with-less-tremor-a-new-strategy
#4
Tarek Alhamad, Karthikeyan Venkatachalam, Reem Daloul, Daniel Brennan, Andrew Malone
No abstract text is available yet for this article.
April 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28403129/singing-a-new-song-outcomes-for-clinical-trials
#5
Andrew F Malone, Daniel C Brennan
No abstract text is available yet for this article.
April 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28403128/an-oxygenated-and-transportable-machine-perfusion-system-fully-rescues-liver-grafts-exposed-to-lethal-ischemic-damage-in-a-pig-model-of-dcd-liver-transplantation
#6
Philippe Compagnon, Eric Levesque, Hassen Hentati, Mara Disabato, Julien Calderaro, Cyrille Feray, Anne Corlu, José Laurent Cohen, Ismail Ben Mosbah, Daniel Azoulay
BACKGROUND: Control of warm ischemia (WI) lesions that occur with donation after circulatory death (DCD) would significantly increase the donor pool for liver transplantation. We aimed to determine whether a novel, oxygenated and hypothermic machine perfusion device (HMP Airdrive system) improves the quality of livers derived from DCDs using a large animal model. METHODS: Cardiac arrest was induced in female large white pigs by IV injection of potassium chloride...
April 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28403127/a-randomized-controlled-clinical-trial-comparing-belatacept-with-tacrolimus-after-de-novo-kidney-transplantation
#7
Gretchen de Graav, Carla C Baan, Marian C Clahsen-van Groningen, Rens Kraaijeveld, Marjolein Dieterich, Wenda Verschoor, Jan H von der Thusen, Dave L Roelen, Monique Cadogan, Jacqueline van de Wetering, Joost van Rosmalen, Wilem Weimar, Dennis A Hesselink
BACKGROUND: Belatacept, an inhibitor of the CD28-CD80/86 co-stimulatory pathway, allows for calcineurin-inhibitor free immunosuppressive therapy in kidney transplantation but is associated with a higher acute rejection risk than ciclosporin. Thus, no biomarker for belatacept-resistant rejection has been validated. In this randomized controlled trial, acute rejection-rate was compared between belatacept- and tacrolimus-treated patients and immunological biomarkers for acute rejection were investigated...
April 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28403126/effector-antitumor-and-regulatory-t-cell-responses-influence-the-development-of-nonmelanoma-skin-cancer-in-kidney-transplant-patients
#8
Elena Crespo, Loreto Fernandez, Marc Lúcia, Edoardo Melilli, Ricardo Lauzurica, Rosa Maria Penin, Ariadna Quer, Sergio Luque, Maria Quero, Anna Manonelles, Joan Torras, Josep Maria Cruzado, Laura Cañas, Josep Maria Grinyó, Oriol Bestard
BACKGROUND: Chronic immunosuppression promotes Nonmelanocytic Squamous Cell Carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth and are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T cell responses due to CNI could contribute to SCC development, whereas conversion to mTOR-i could recover this protective immune response. METHODS: Peripheral tumor-specific T cell responses against main SCC-derived antigens using the IFN-γ ELISPOT assay and intratumor and circulating immune phenotypes (CD4+T, CD8+T, CD20+B, CD56+NK, FOXP3+Tregs) were explored in a cross-sectional analysis in 59 kidney transplant patients with SCC on CNI (KT-CNI-SCC) or mTOR-i (KT-mTORi-SCC), 25 nontransplants developing SCC (NoKT-SCC) and 6 healthy controls...
April 11, 2017: Transplantation
https://www.readbyqxmd.com/read/28376033/causes-and-consequences-of-the-worldwide-belatacept-shortage
#9
Steven Gabardi, Teun van Gelder
No abstract text is available yet for this article.
April 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28376032/chronic-hepatitis-e-viral-infection-after-liver-transplantation-a-regression-of-fibrosis-following-antiviral-therapy
#10
Alessandra Mazzola, Margherita Tran Minh, Frédéric Charlotte, Aisha Hdjii, Denis Bernard, Dominique Wendum, Yvon Calmus, Filomena Conti
BACKGROUND: hepatitis E virus (HEV) infection is increasingly being reported in immunocompromised patients, and particularly organ transplant recipients. In this context, HEV infection frequently evolves to chronic infection with a rapid progression of fibrosis to cirrhosis. Ribavirin monotherapy and a minimisation of immunosuppression represent the treatment of choice, with a good response rate. However, no data are available on whether treatment can achieve a regression of liver fibrosis in chronic HEV patients...
April 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28376031/the-immune-response-to-epstein-barr-virus-and-implications-for-posttransplant-lymphoproliferative-disorder
#11
Olivia M Martinez, Sheri M Krams
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication in organ transplant recipients and is most often associated with the Epstein Barr virus (EBV). EBV is a common gammaherpes virus with tropism for B lymphocytes and infection in immunocompetent individuals is typically asymptomatic and benign. However, infection in immunocompromised or immunosuppressed individuals can result in malignant B cell lymphoproliferations such as PTLD. EBV+ PTLD can arise following primary EBV infection, or because of reactivation of a prior infection, and represents a leading malignancy in the transplant population...
April 4, 2017: Transplantation
https://www.readbyqxmd.com/read/28376038/elbasvir-grazoprevir-use-in-postliver-transplantation-patients-on-hemodialysis
#12
Michelle T Martin, Sean Koppe
BACKGROUND: Current national hepatitis C virus (HCV) guidelines do not recommend the use of elbasvir/grazoprevir (EBR/GZR) in postliver transplantation (LT) patients due to drug-drug interactions (DDIs) with immunosuppression agents. However, recommendations do not address the treatment of HCV in renally-impaired post-LT patients. Treatment regimens that are recommended for post-LT patients are not safe in patients with severe renal impairment and patients on dialysis. EBR/GZR is approved for use in patients with renal impairment and patients on dialysis, but not in the post-LT setting...
April 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28376037/harnessing-advances-in-t-regulatory-cell-biology-for-cellular-therapy-in-transplantation
#13
Avery J Lam, Romy E Hoeppli, Megan K Levings
Cellular therapy with CD4FOXP3 T regulatory cells (Treg) is a promising strategy to induce tolerance after solid-organ transplantation or prevent graft-versus-host disease after transfer of hematopoietic stem cells. Tregs currently used in clinical trials are either polyclonal, donor- or antigen-specific. Aside from variations in isolation and expansion protocols, however, most therapeutic Treg cell-based products are much alike. Ongoing basic-science work has provided considerable new insight into multiple facets of Treg biology, including their stability, homing, and functional specialization; integrating these basic-science discoveries with clinical efforts will support the development of next-generation therapeutic Tregs with enhanced efficacy...
April 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28376036/evaluation-of-skeletal-muscle-function-in-lung-transplant-candidates
#14
Dmitry Rozenberg, Lianne G Singer, Margaret Herridge, Roger Goldstein, Lisa Wickerson, Noori A Chowdhury, Sunita Mathur
BACKGROUND: Lung transplantation (LTx) is offered to older and more complex patients who may be at higher risk of skeletal muscle dysfunction, but the clinical implications of this remain uncertain. The study aims were to characterize deficits in skeletal muscle mass, strength and physical performance and examine the associations of these deficits with clinical outcomes. METHODS: Fifty LTx candidates (58% male, 59 ± 9 years) were prospectively evaluated for skeletal muscle deficits: muscle mass using bio-electrical impedance, quadriceps, respiratory muscle and handgrip strength, and physical performance with the Short Physical Performance Battery...
April 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28376035/progress-towards-hhv-8-prevention-after-transplantation-in-search-for-optimal-diagnostic-strategies
#15
Raymund R Razonable
No abstract text is available yet for this article.
April 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28376034/rapid-discontinuation-of-prednisone-in-kidney-transplant-recipients-15-year-outcomes-from-the-university-of-minnesota
#16
Oscar Kenneth Serrano, Raja Kandaswamy, Kristen Gillingham, Srinath Chinnakotla, Ty B Dunn, Erik Finger, William Payne, Hassan Ibrahim, Aleksandra Kukla, Richard Spong, Naim Issa, Timothy L Pruett, Arthur Matas
BACKGROUND: Short- and intermediate-term results have been reported after rapid discontinuation of prednisone (RDP) in kidney transplant recipients. Yet there has been residual concern about late graft failure in the absence of maintenance prednisone. METHODS: From October 1, 1999, through June 1, 2015, we performed a total of 1553 adult 1st and 2nd kidney transplants-1021 with a living donor (LD), 532 with a deceased donor (DD)-under our RDP protocol. We analyzed the 15-year actuarial overall patient survival (PS), graft survival (GS), death-censored graft survival (DCGS), and acute rejection-free survival (ARFS) rates for RDP compared to historical controls on maintenance prednisone...
April 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28358727/salvage-islet-auto-transplantation-after-relaparatomy
#17
Gianpaolo Balzano, Rita Nano, Paola Maffi, Alessia Mercalli, Raffaelli Melzi, Francesca Aleotti, Francesca Gavazzi, Cesare Berra, Francesco De Cobelli, Massimo Venturini, Paola Magistretti, Marina Scavini, Giovanni Capretti, Alessandro Del Maschio, Antonio Secchi, Alessandro Zerbi, Massimo Falconi, Lorenzo Piemonti
BACKGROUND: To assess feasibility, safety and metabolic outcome of islet auto transplantation (IAT) in patients undergoing completion pancreatectomy because of sepsis or bleeding following pancreatic surgery. METHODS: From November 2008 to October 2016, 22 patients were candidates to salvage IAT during emergency relaparotomy because of postpancreatectomy sepsis (n=11) or bleeding (n=11). Feasibility, efficacy, and safety of salvage IAT were compared to those documented in a cohort of 36 patients who were candidate to simultaneous IAT during nonemergency preemptive completion pancreatectomy through the pancreaticoduodenectomy...
March 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28353493/hypothermic-machine-perfusion-of-liver-grafts-can-safely-extend-cold-ischemia-for-up-to-20-hours-in-cases-of-necessity
#18
Riccardo De Carlis, Andrea Lauterio, Fabio Ferla, Stefano Di Sandro, Raffaella Sguinzi, Luciano De Carlis
No abstract text is available yet for this article.
March 28, 2017: Transplantation
https://www.readbyqxmd.com/read/28353492/wait-time-of-6-and-18-months-predicts-hepatocellular-carcinoma-recurrence-after-liver-transplantation-proposing-a-wait-time-sweet-spot
#19
Neil Mehta, Julie Heimbach, David Lee, Jennifer L Dodge, Denise Harnois, Justin Burns, William Sanchez, John P Roberts, Francis Y Yao
BACKGROUND: It has been postulated that short wait time before liver transplant (LT) for hepatocellular carcinoma (HCC) results in the inclusion of tumors with aggressive biology, but prolonged wait time could result in a shift to more aggressive tumor behavior. We therefore test the hypothesis that a wait time "sweet spot" exists with a lower risk for HCC recurrence compared to the other 2 extremes. METHODS: This multi-center study included 911 patients from 3 LT centers with short, medium and long wait times (median of 4, 7, and 13 months, respectively) who received MELD exception listing for HCC from 2002-2012...
March 28, 2017: Transplantation
https://www.readbyqxmd.com/read/28353491/nonprogrammed-vascular-access-is-associated-with-greater-mortality-in-patients-who-return-to-hemodialysis-with-a-failing-renal-graft
#20
Gustavo Laham, Gervasio Soler Pujol, Antonio Vilches, Ana Cusumano, Carlos Diaz
BACKGROUND: In incident hemodialysis (HD) patients the use of catheters is associated with a worse prognosis when compared to those with an arteriovenous fistula (AVF), but the role of vascular access (VA) type in the morbidity and mortality of patients returning to HD with a failing renal allograft is unknown. We aimed to determine the associations between the type of vascular access and mortality in this population. METHODS: This was a retrospective observational cohort study of 138 patients who initiated dialysis after kidney transplant failure between 1995 and 2014...
March 28, 2017: Transplantation
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