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Transplantation

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https://www.readbyqxmd.com/read/28817435/author-s-reply-how-to-report-and-interpret-bioequivalence-data-in-solid-organ-transplant-recipients
#1
Wolfgang Arns
No abstract text is available yet for this article.
August 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28817434/everolimus-is-associated-with-less-weight-gain-than-tacrolimus-2-years-following-liver-transplantation-results-of-a-randomized-multicenter-study
#2
Michael Charlton, Mary Rinella, Dharmesh Patel, Kevin McCague, Julie Heimbach, Kymberly Watt
BACKGROUND: Weight gain early after transplant is a risk factor for posttransplant metabolic syndrome (PTMS), cardiovascular events, and renal insufficiency. The impact of mTOR inhibition on posttransplant weight gain and the development of PTMS components postliver transplantation were examined in a randomized, controlled study. METHODS: Following a run-in period, patients (N = 719) were randomized at 30±5 days posttransplant in a 1:1:1 ratio to 3 treatment groups: (i) everolimus (EVR) + reduced tacrolimus (TAC)(n=245); (ii) TAC control (n=243) or (iii) TAC elimination (n=231)...
August 15, 2017: Transplantation
https://www.readbyqxmd.com/read/28795982/treatment-of-patients-with-hepatitis-c-virus-infection-genotype-4-with-ledipasvir-sofosbuvir-in-the-liver-transplant-setting
#3
Faisal Abaalkhail, Hussein Elsiesy, Hany Elbeshbeshy, Mohamed Shawkat, Sarra Yousif, Waheed Ullah, Saleh Alabbad, Ahmed Al-Jedai, Aziza Ajlan, Dieter Broering, Sammy Saab, Mohammed Al Sebayel, Waleed Al-Hamoudi
BACKGROUND: Hepatitis C virus infection is a major cause of liver cirrhosis and hepatocellular carcinoma and the leading indication for liver transplantation. In the Middle East, genotype 4 HCV infection is the most common genotype. However, limited data exists on the treatment of genotype-4 in the liver transplant setting. We evaluated the safety and efficacy of ledipasvir-sofosbuvir (LDV/SOF) in treating HCV genotype-4 infected patients with cirrhosis or postliver transplantation. METHODS: This prospective, single-arm, observational study includes cohort of patients with cirrhosis before liver transplantation (Cohort A) and a cohort of postliver transplantation patients (Cohort B)...
August 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28795981/summary-of-the-british-transplantation-society-uk-guidelines-for-hepatitis-e-and-solid-organ-transplantation
#4
Stuart McPherson, Ahmed M Elsharkawy, Michael Ankcorn, Samreen Ijaz, James Powell, Ian Rowe, Richard Tedder, Peter A Andrews
The incidence and prevalence of hepatitis E virus (HEV) infection has increased in many developed countries over the last decade, predominantly due to infection with genotype 3 (G3) HEV. Infection with HEV G3 is important in transplant recipients because it can persist in immunosuppressed individuals, leading if untreated to the development of chronic hepatitis and significant liver fibrosis. The British Transplantation Society (BTS) has developed Guidelines for "Hepatitis E & Solid Organ Transplantation" to inform clinical teams and patients about hepatitis E, to help increase the recognition of persistent hepatitis E infection, and to provide clear guidance on its management...
August 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28787309/external-validation-of-kidney-donor-risk-index-kdri-does-not-mitigate-its-basic-limitations
#5
Pooja Budhiraja, Bruce Kaplan
No abstract text is available yet for this article.
August 5, 2017: Transplantation
https://www.readbyqxmd.com/read/28787308/technique-and-outcomes-of-less-invasive-lung-retransplantation
#6
Wiebke Sommer, Fabio Ius, Christian Kühn, Murat Avsar, Jawad Salman, Thierry Siemeni, Carsten Müller, Nicolaus Schwerk, Mark Greer, Jens Gottlieb, Tobias Welte, Axel Haverich, Igor Tudorache, Gregor Warnecke
BACKGROUND: Lung retransplantation is a demanding procedure with outcomes lagging primary transplantation. We implemented less invasive surgical techniques aiming at improving early outcomes. Here, we wish to describe these techniques and analyze clinical outcomes. METHODS: Since April 2010 a protocol of less invasive techniques was applied to all lung retransplantations. This protocol comprises bilateral lung retransplantation via sternum-sparing anterolateral thoracotomies, off-pump surgery, and empiric administration of 2 g fibrinogen and 2 platelet concentrates...
August 5, 2017: Transplantation
https://www.readbyqxmd.com/read/28787311/living-kidney-donor-phenotype-and-likelihood-of-postdonation-follow-up
#7
Rhiannon D Reed, Brittany A Shelton, Paul A MacLennan, Deirdre Sawinski, Jayme E Locke
BACKGROUND: The Organ Procurement and Transplantation Network requires that United States transplant centers maintain follow-up with living donors for 2 years postdonation, but lack of donor follow-up is pervasive. Donor characteristics, including younger age, minority race, and lower education, have been associated with incomplete follow-up, but it is unknown whether altruistic donors, having no prior connection to their recipient, differ from traditional donors in their likelihood of follow-up...
August 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28787310/how-to-report-and-interpret-bioequivalence-data-in-solid-organ-transplant-recipients
#8
Anders Åsberg, Ida Robertsen, Karsten Midtvedt
No abstract text is available yet for this article.
August 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28777210/rapamycin-prolongs-graft-survival-and-induces-cd4-ifn-%C3%AE-il-10-regulatory-type-1-cells-in-old-recipient-mice
#9
Markus Quante, Timm Heinbokel, Karoline Edtinger, Koichiro Minami, Hirofumi Uehara, Yeqi Nian, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Stefan G Tullius
BACKGROUND: Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. METHODS: Here, we assessed the impact of Rapamycin on alloimmune responses in old recipients using a fully MHC-mismatched murine transplantation model. RESULTS: Old untreated recipients displayed a prolonged skin graft survival compared to their young counterparts, an observation that confirmed data of our previous experiments...
August 2, 2017: Transplantation
https://www.readbyqxmd.com/read/28767535/refractory-vascular-rejection-in-a-hand-allograft-in-the-presence-of-antibodies-against-angiotensin-ii-type-1-receptor
#10
Karen M Dwyer, Robert Carroll, Prue Hill, Samantha Bateman, Chris Baker, Robyn G Langham, Wayne Morrison
No abstract text is available yet for this article.
August 1, 2017: Transplantation
https://www.readbyqxmd.com/read/28767534/a-cost-comparison-for-telehealth-utilization-in-the-kidney-transplant-waitlist-evaluation-process
#11
Rachel C Forbes, Diane B Rybacki, Tommy B Johnson, Angela Hannah-Gillis, David Shaffer, Douglas A Hale
BACKGROUND: There have been limited publications on telehealth utilization in transplantation with no prior reports of telehealth-related costs for pretransplant evaluations. The aim of this study is to compare costs throughout the evaluation process for those patients assessed initially by telehealth to those seen in-person. METHODS: All patients approved for kidney transplant waitlist evaluation at our center from March 2013 thru May 2016 with decisions were included in this study...
August 1, 2017: Transplantation
https://www.readbyqxmd.com/read/28767533/gender-equity-in-transplantation-a-report-from-the-women-in-transplantation-workshop-of-the-transplantation-society-of-australia-and-new-zealand
#12
Karen M Dwyer, Carolyn Clark, Kelli MacDonald, Miranda A Paraskeva, Natasha Rogers, Jessica Ryan, Angela Webster, Germaine Wong
The exponential growth of young talented females choosing science and medicine as their professional career over the past decade is substantial. Currently, more than half of the Australian medical doctoral graduates and early career researchers are comprised of women, but less than 20% of all academic professorial staff are female. The loss of female talent in the hierarchical ladder of Australian academia is a considerable waste of government investment, productivity and scientific innovation. Gender disparity in the professional workforce composition is even more striking within the field of transplantation...
August 1, 2017: Transplantation
https://www.readbyqxmd.com/read/28749820/mounting-clinical-evidence-with-tacrolimus-generic-products
#13
Rita R Alloway
No abstract text is available yet for this article.
July 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28749819/engraftment-and-repopulation-potential-of-late-gestation-fetal-rat-hepatocytes
#14
Joan M Boylan, Heather Francois-Vaughan, Philip A Gruppuso, Jennifer A Sanders
BACKGROUND: The limited availability of donor organs has led to a search for alternatives to liver transplantation to restore liver function and bridge patients to transplantation. We have shown that the proliferation of late gestation (embryonic day 19; ED19) fetal rat hepatocytes is mitogen-independent, and that mechanisms regulating of mRNA translation, cell cycle progression and gene expression differ from those of adult rat hepatocytes. In the present study, we investigated whether E19 fetal hepatocytes can engraft and repopulate an injured adult liver...
July 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28749818/fatal-septic-shock-triggered-by-donor-transmitted-varicella-zoster-virus-reinfection-3-days-after-lung-transplantation
#15
Samuel Lehingue, Romain Rambaud, Christophe Guervilly, Mélanie Adda, Jeanmarie Forel, Nadim Cassir, Christine Zandotti, Sami Hraiech, Laurent Papazian
No abstract text is available yet for this article.
July 27, 2017: Transplantation
https://www.readbyqxmd.com/read/28737605/glomerulus-on-a-chip-life-up
#16
Nureddin Ashammakhi, Elmahdi A Elkhammas, Anwarul Hasan
No abstract text is available yet for this article.
July 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28737604/the-democratization-of-genomic-inquiry-empowers-our-understanding-of-nephrotic-syndrome
#17
Matthew G Sampson
No abstract text is available yet for this article.
July 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28737603/deceased-donor-liver-size-and-the-sex-based-disparity-in-liver-transplantation
#18
Mary G Bowring, Jessica M Ruck, Christine E Haugen, Allan B Massie, Dorry L Segev, Sommer E Gentry
No abstract text is available yet for this article.
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28731910/new-answers-to-old-conundrums-what-antibodies-exosomes-and-inflammasomes-bring-to-the-conversation-canadian-national-transplant-research-program-international-summit-report
#19
Mélanie Dieudé, Lori J West, Daniel A Muruve, Lakshman Gunaratman, Thalachallour Mohanakumar, Emmanuel Zorn, Christopher W Cairo, Darren H Freed, Kirk R Schultz, Robert L Fairchild, Marie-Josée Hébert
Antibody-mediated injury is a major cause of allograft dysfunction and loss. Antibodies to ABH(O) blood group antigens are classical mediators of ABO-incompatible (ABOi) graft rejection, while donor-specific anti-HLA antibodies and, more recently, autoantibodies are appreciated as important contributors to allograft inflammation and dysfunction. In August 2016, the International Summit of the Canadian National Transplant Research Program focused on recent advances in the field of antibody-mediated rejection...
July 21, 2017: Transplantation
https://www.readbyqxmd.com/read/28731909/trichodysplasia-spinulosa
#20
Rachel K Rosenstein, Christine J Ko, Oscar R Colegio
No abstract text is available yet for this article.
July 21, 2017: Transplantation
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