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Masaru Ishida, Shigeru Miyagawa, Atsuhiro Saito, Satsuki Fukushima, Akima Harada, Emiko Ito, Fumiya Ohashi, Tadashi Watabe, Jun Hatazawa, Katsuhisa Matsuura, Yoshiki Sawa
BACKGROUND: Somatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent SC-derived cardiomyocytes (iPS-CMs) are more effective than somatic SCs, such as skeletal myoblasts (SM) and mesenchymal (M)SCs, in promoting functional recovery upon transplantation in a porcine model of myocardial infarction (MI). METHODS: Myocardial injury was induced by ameroid ring placement in immunosuppressed female mini-pigs; after 1 month, epicardial cell transplantation was performed with iPS-CMs (n = 7), SMs (n = 7), and MSCs (n = 7)...
August 17, 2018: Transplantation
Amir Taher, Benjamin Zhu, Sophia Ma, Albert Shun, Anne M Durkan
BACKGROUND: The incidence and types of intraabdominal complications following pediatric transplantation are not well established and specific risk groups have not been clearly identified. METHODS: A retrospective chart review of all pediatric transplant recipients, between 1995 and 2016 was undertaken. Intraabdominal complications were grouped into 4 categories: fluid collections, gastrointestinal, vascular and urogenital. Donor, recipient, and transplant characteristics were evaluated using univariate and multivariate logistic regression...
August 15, 2018: Transplantation
Florence Renaud, Mikael Chetboun, Julien Thevenet, Nathalie Delalleau, Valery Gmyr, Thomas Hubert, Caroline Bonner, Mathieu Messager, Emmanuelle Leteurtre, Christophe Mariette, Julie Kerr-Conte, Guillaume Piessen, François Pattou
BACKGROUND: total pancreatectomy with intraportal islet autotransplantation (TPIAT) rather than partial pancreatectomy could represent a major shift in the management of patients with resectable pancreatic ductal adenocarcinoma (PDAC) when risks of postoperative pancreatic fistula are well identified. This approach provides a theoretical risk of tumor cell dissemination when islet cells are transplanted into the portal vein. Our objective was to demonstrate the safety of TPIAT in PDAC in a mouse preclinical model of subcutaneous xenotransplantation of human cells isolated from pancreatic specimen during partial pancreatectomy performed for PDAC...
August 15, 2018: Transplantation
Tetsu Oura, Kiyohiko Hotta, Ivy Rosales, Abbas Dehnadi, Kent Kawai, Hang Lee, A Benedict Cosimi, Tatsuo Kawai
BACKGROUND: We recently reported anti-CD40 monoclonal antibody and rapamycin (aCD40/rapa) to be a reliable, nontoxic, immunosuppressive regimen for combined islet and kidney transplantation (CIKTx) in nonhuman primates (NHPs). In the current study, we attempted to induce allograft tolerance through the mixed chimerism approach using a conditioning regimen with aCD40 and belatacept (Bela). METHODS: Five CIKTx or kidney transplant (KTx) recipients were treated with aCD40/rapa for 4 months...
August 15, 2018: Transplantation
Schwarz Christoph, Wekerle Thomas
No abstract text is available yet for this article.
August 15, 2018: Transplantation
Diego Moya-Nájera, Ángel Moya-Herraiz, Pedro Gargallo, Joaquin Calatayud, Javier Escrig-Sos, Juan C Colado
BACKGROUND: Although some studies have reported significant improvements in physical function and strength after training programs on Liver Transplant (LT) recipients, there is a lack of knowledge on how it affects in static and dynamic balance, being an important part of these participants' tasks development. The aim of the study was to determine the effects of a 6-month multicomponent circuit training program on static and dynamic balance in LT participants. METHODS: 54 participants were randomized at 6 months after LT into 2 groups: exercise group (EXER) and control group (CONTROL), with repeat testing at 6 (baseline) and 12 months after LT...
August 15, 2018: Transplantation
Jens G Brockmann, Amir Butt, Hussa F Al Hussaini, Hadeel AlMana, Khaled AlSaad, Moheeb Al-Awwami, Dieter C Broering, Tariq Ali
BACKGROUND: Histological evaluation of the pancreas graft is usually done on demand resulting in significant delays. This analysis reports on endoscopic protocol duodenal graft biopsies at regular intervals to determine feasibility, safety and monitoring benefits. METHODS: Protocol duodenal graft biopsies in 27 18 consecutive pancreas transplants (10 simultaneous pancreas kidney [SPK], 17 pancreas after kidney [PAK]) with a follow-up of a minimum of 12 months were performed at days 14, 30, 90, 180, 360, 430...
August 15, 2018: Transplantation
Bram W Wisse, Elena G Kamburova, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, Eric Spierings, Cornelis E Hack, Franka E van Reekum, Arjan D van Zuilen, Marianne C Verhaar, Michiel L Bots, Adriaan C A D Drop, Loes Plaisier, Marc A J Seelen, Jan Stephan Sanders, Bouke G Hepkema, Annechien J A Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Christien E Voorter, Lotte Wieten, Elly M van Duijnhoven, Mariëlle A C J Gelens, Maarten H L Christiaans, Frans J van Ittersum, Shaikh A Nurmohamed, Junior N M Lardy, Wendy Swelsen, Karlijn A M I van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Frederike J Bemelman, Andries J Hoitsma, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Sebastiaan Heidt, Dave L Roelen, Frans H Claas, Henny G Otten
BACKGROUND: There is no consensus in the literature on the interpretation of single antigen bead (SAB) positive for a specific HLA antibody. METHODS: To inform the debate, we studied the relationship between various SAB positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants. RESULTS: First, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute MFIs...
August 13, 2018: Transplantation
Wan-Tseng Hsu, Cheng-Hsin Lin, Hsiang-Yiang Jui, Ya-Hsuan Tseng, Chia-Tung Shun, Ming-Chu Hsu, Kenneth Kun-Yu Wu, Chii-Ming Lee
BACKGROUND: CXCR4 blockade is pursued as an alternative to mesenchymal stem cell (MSC) treatment in transplantation based on our previous report that burixafor, through CXCR4 antagonism, mobilizes immunomodulatory MSCs. Here, we explored the efficacy of combining mycophenolate mofetil (MMF)-based immunosuppressants with repetitive burixafor administration. METHODS: Swine heterotopic cardiac allograft recipients received MMF and corticosteroids (control, n = 10) combined with burixafor as a 2-dose (burixafor2D, n = 7) or 2-dose plus booster injections (burixafor2D+B, n = 5) regimen...
August 8, 2018: Transplantation
Amy C Kelly, Kate E Smith, William G Purvis, Catherine G Min, Craig S Weber, Amanda M Cooksey, Craig Hasilo, Steven Paraskevas, Thomas M Suszynski, Bradley P Weegman, Miranda J Anderson, Leticia E Camacho, Robert C Harland, Tom Loudovaris, Jana Jandova, Diana S Molano, Nicholas D Price, Ivan G Georgiev, William E Scott, Derek Manas, James Shaw, Doug O'Gorman, Tatsuya Kin, Fiona M McCarthy, Gregory L Szot, Andrew M Posselt, Peter G Stock, Theodore Karatzas, William J Shapiro, Ronald M Lynch, Sean W Limesand, Klearchos K Papas
BACKGROUND: All human islets used in research and for the clinical treatment of diabetes are subject to ischemic damage during pancreas procurement, preservation, and islet isolation. A major factor influencing islet function is exposure of pancreata to cold ischemia during unavoidable windows of preservation by static cold storage (SCS). Improved preservation methods may prevent this functional deterioration. In the present study, we investigated whether pancreas preservation by gaseous oxygen perfusion (persufflation) better preserved islet function versus SCS...
August 8, 2018: Transplantation
H Auråen, M T Durheim, G Dellgren, P Hämmäinen, H Larsson, O Geiran, H H Lawaetz Schultz, I Leuckfeld, M Iversen, A E Fiane, A M Holm
BACKGROUND: Organs from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are unclear. This multicenter study reviews all bilateral lung transplantations (BLTx) from donors ≥55 years stratified by recipient diagnosis, and compares outcomes with transplantations from younger donors. METHODS: All BLTx recipients (excluding ReTx) at 5 Scandiatransplant centers between 2000 and 2013 were included (n=913)...
August 6, 2018: Transplantation
Sarah A Hosgood, Michael L Nicholson
No abstract text is available yet for this article.
August 6, 2018: Transplantation
Giuseppe Cullaro, Ryutaro Hirose, Jennifer C Lai
BACKGROUND: Previous simultaneous liver-kidney transplant (SLK) allocation was based on serum creatinine, a metric that disadvantaged women relative to men. A recent SLK policy change utilizes eGFR, which accounts for sex-based differences in creatinine. METHODS: To understand the impact of this new policy, we analyzed nonstatus 1 adults listed for liver transplantation (LT) from 5/2007-7/2014, excluding those with exceptions. We defined patients who met the new SLK policy as having an eGFR<60 ml/min for 90 days, with a final eGFR<30 ml/min...
August 6, 2018: Transplantation
Kunam S Reddy, Bruce Kaplan
No abstract text is available yet for this article.
August 6, 2018: Transplantation
Naoto Fukunaga, Ved Bissoondath, Vivek Rao
No abstract text is available yet for this article.
August 6, 2018: Transplantation
Ashley Lau, Rebecca E Scully, Mats Brännström, Stefan G Tullius
No abstract text is available yet for this article.
August 6, 2018: Transplantation
Kevin Bui, Vikram Kilambi, James R Rodrigue, Sanjay Mehrotra
BACKGROUND: Recorded at the time of transplant and reported to the Organ Procurement and Transplantation Network (OPTN), patient's functional status is measured using the Karnofsky Performance Score (KPS), ranging 0-100. Functional status analysis may provide insights on candidate listing and posttransplant survival outcomes for deceased-donor kidney transplants (DDKT). METHODS: The cohort consisted of adult DDKT recipients transplanted beginning January 2007. One-year and 3-year Cox models for posttransplant survival were fitted with current Scientific Registry of Transplant Recipients (SRTR) variables and KPS...
August 6, 2018: Transplantation
Stijn E Verleden, Olivier Gheysens, Karolien E Goffin, Bart M Vanaudenaerde, Erik K Verbeken, Birgit Weynand, Dirk E Van Raemdonck, Geert M Verleden, Robin Vos
BACKGROUND: Differential diagnosis of phenotypes of chronic lung allograft dysfunction (CLAD) remains troublesome. We hypothesized that F-FDG PET/CT may help in differential diagnosis of CLAD phenotypes, as it showed promising results regarding diagnosis and prognosis in interstitial lung diseases. METHODS: A monocentric, retrospective study was performed including all lung transplant recipients suffering from bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) who underwent F-FDG PET/CT scan, in comparison with stable lung transplant recipients...
August 6, 2018: Transplantation
Atibordee Meesing, Roshini S Abraham, Raymund R Razonable
INTRODUCTION: Control of cytomegalovirus (CMV) infection after solid organ transplantation (SOT) requires a functional immune system. We assessed the association between quantitation and function of CMV-specific CD8+ T cells and CMV infection in SOT recipients. METHODS: During a 10-year period, selected kidney, heart, lung, pancreas, liver and composite tissue recipients were tested for CMV-specific CD8+ T cells immune competence (CMV-CD8+), as measured by enumeration, interferon-gamma production and CD107a/b degranulation...
August 6, 2018: Transplantation
Seokha Yoo, Eun Jin Jang, Nam-Joon Yi, Ga Hee Kim, Dal Ho Kim, Hannah Lee, Chul-Woo Jung, Ho Geol Ryu
BACKGROUND: The relationship between institutional case volume and clinical outcomes after living donor liver transplantation is not clarified. METHODS: We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between January 2007 and December 2016, 7073 adult living donor liver transplantations were performed at 50 centers in Korea. Centers were categorized according to the average annual number of liver transplantations: >50, 10 to 50, and <10...
August 6, 2018: Transplantation
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