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Transplantation

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https://www.readbyqxmd.com/read/30308576/donor-specific-cell-free-dna-as-a-biomarker-in-solid-organ-transplantation-a-systematic-review
#1
Simon R Knight, Adam Thorne, Maria Letizia Lo Faro
BACKGROUND: There is increasing interest in the use of noninvasive biomarkers to reduce the risks posed by invasive biopsy for monitoring of solid organ transplants (SOT). One such promising marker is the presence of donor-derived cell-free DNA (dd-cfDNA) in the urine or blood of transplant recipients. METHODS: We systematically reviewed the published literature investigating the use of cfDNA in monitoring of graft health following SOT. Electronic databases were searched for studies relating cfDNA fraction or levels to clinical outcomes, and data including measures of diagnostic test accuracy (DTA) were extracted...
October 11, 2018: Transplantation
https://www.readbyqxmd.com/read/30308575/a-worldwide-survey-of-live-liver-donor-selection-policies-at-24-centers-with-a-combined-experience-of-19-009-adult-living-donor-liver-transplants
#2
A S Soin, R J Chaudhary, H Pahari, E A Pomfret
BACKGROUND: While surgical technique in LDLT has evolved with a focus on donor safety and recipient challenges, the donor selection criteria remain considerably disparate. METHODS: A questionnaire on donor selection was sent to 41 centers worldwide. 24 centers with a combined experience of 19009 LDLTs responded. RESULTS: Centers were categorized into predominantly LDLT (18) or DDLT (6), and high (10) or low volume (14) centers.At the majority of centers, the minimum acceptable GRWR was < 0...
October 11, 2018: Transplantation
https://www.readbyqxmd.com/read/30300289/recommendations-for-management-and-treatment-of-nonalcoholic-steatohepatitis
#3
Vlad Ratziu, Marwan Ghabril, Manuel Romero-Gomez, Gianluca Svegliati-Baroni
The prevalence of nonalcoholic liver disease (NAFLD) is increasing worldwide in conjunction with the epidemic increase in obesity and metabolic risk factors. Consequently, NAFLD has become a leading indication for liver transplantation. While genetic factors play an important role in the pathogenesis of NAFLD, detrimental lifestyle trends favoring a calorically unrestricted diet rich in carbohydrates and unsaturated fat, prolonged sedentary periods or limited physical activity have major metabolic implications...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300288/the-transplant-index-ti-a-novel-method-to-predict-adult-liver-transplant-waitlist-outcomes
#4
Michael Kueht, Syed Shahyan Bakhtiyar, Jessie Wu, Hao Liu, Warren H Chan, Henrik Petrowsky, Irbaz B Riaz, Ronald Cotton, Nhu Thao Galvan, Christine O'Mahony, John Goss, Abbas Rana
BACKGROUND: The field of transplantation is shifting outcome priorities from 1-year survival to more comprehensive metrics including transplant rate and waitlist mortality. Identifying disenfranchised candidates (high waitlist death risk, low transplantation chance) can be a focus to improve outcomes. METHODS: Given waitlist outcomes, (continued waiting, death, and transplantation), we aimed to identify factors predicting the likelihood candidates would undergo transplant or death by performing multivariate competing risk analyses of 121 198 candidates in the United Network for Organ Sharing database...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300287/nonalcoholic-fatty-liver-disease-basic-pathogenetic-mechanisms-in-the-progression-from-nafld-to-nash
#5
Irene Pierantonelli, Gianluca Svegliati-Baroni
Nonalcoholic fatty liver disease (NAFLD) represents a growing cause of chronic liver injury, especially in Western Countries, where it is becoming the most frequent indication for liver transplantation (OLTx). NAFLD encompasses a spectrum of diseases that from simple steatosis (pure NAFLD) can progress to Nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). The pathogenesis of NAFLD and the mechanisms behind its progression to NASH have been extensively studied. However, while the processes that determine fat accumulation are mostly clear, the mechanisms associated with the progression of the disease are not fully characterized...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300286/the-outcome-of-allogeneic-hematopoietic-stem-cell-transplantation-for-inherited-diseases-is-influenced-by-hla-match-year-of-transplantation-and-immunized-female-donor
#6
Olle Ringden, Mats Remberger, Britt Gustafsson, Gianluca Moretti, Jonas Mattsson, Jacek Winiarski, Behnam Sadeghi
BACKGROUND: For many inborn errors of metabolism (IEM), allogeneic hematopoietic stem cell transplantation (HUSCT) is the only cure. METHODS: We report the outcome in 160 patients with inherited diseases, who were treated with HSCT in 3 decades. Median age was 3 years (range 0.1-63). Grafts were from matched related donors (MRDs, 56), matched unrelated donors (MUDs, 66), or HLA-mismatched donors (38). RESULTS: Graft failure (GF) occurred in 26 patients (16%), severe acute graft-versus-host disease (GVHD) in 9 (6%), and chronic GVHD in 23 (12%)...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300285/temporal-trends-associated-with-the-rise-in-alcoholic-liver-disease-related-liver-transplantation-in-the-united-states
#7
George Cholankeril, Chiranjeevi Gadiparthi, Eric R Yoo, Brittany B Dennis, Andrew A Li, Menghan Hu, Katherine Wong, Donghee Kim, Aijaz Ahmed
BACKGROUND: In the United States, alcoholic liver disease (ALD) has recently become the leading indication for liver transplantation (LT). METHODS: Using the United Network for Organ Sharing registry, we examined temporal trends in adult liver transplant waitlist registrants and recipients with chronic liver disease (CLD) due to ALD from 2007 to 2016. RESULTS: From 2007 to 2016, ALD accounted for 20.4% (18 399) of all CLD waitlist (WL) additions...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300284/establishing-a-core-outcome-measure-for-life-participation-a-standardized-outcomes-in-nephrology-kidney-transplantation-song-tx-consensus-workshop-report
#8
Angela Ju, Michelle A Josephson, Zeeshan Butt, Sheila Jowsey-Gregoire, Jane Tan, Quinetta Taylor, Kevin Fowler, Fabienne Dobbels, Fergus Caskey, Vivekanand Jha, Jayme Locke, Greg Knoll, Curie Ahn, Camilla S Hanson, Benedicte Sautenet, Karine Manera, Jonathan C Craig, Martin Howell, Claudia Rutherford, Allison Tong
BACKGROUND: Kidney transplantation confers substantial survival and quality of life benefits for many patients with end-stage kidney disease compared with dialysis, but complications and side-effects of immunosuppression can impair participation in daily life activities. Life participation is a critically important patient-reported outcome for kidney transplant recipients but is infrequently and inconsistently measured in trials. We convened a consensus workshop on establishing an outcome measure for life participation for use in all trials in kidney transplantation...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300283/importance-of-hematopoietic-mixed-chimerism-for-induction-of-renal-allograft-tolerance-in-nonhuman-primates
#9
Cornelius C Thaiss, Tetsu Oura, Hajime Sasaki, Abbas Dehnadi, Masatoshi Matsunami, Ivy A Rosales, Benedict A Cosimi, Tatsuo Kawai
BACKGROUND: Although induction of durable mixed chimerism is required for murine skin allograft tolerance, renal allograft tolerance has been achieved after induction of only transient mixed chimerism in nonhuman primates (NHPs) and humans. To better define the level/duration of chimerism required for stable renal allograft tolerance, we retrospectively analyzed these parameters and compared them with transplant outcomes in NHP combined kidney and bone marrow transplant (CKBMT) recipients...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300282/urinary-timp-2-predicts-the-presence-and-duration-of-delayed-graft-function-in-donation-after-circulatory-death-kidney-transplant-recipients
#10
Jonna R Bank, Renée Ruhaak, Darius Soonawala, Oleg Mayboroda, Fred P Romijn, Cees van Kooten, Christa M Cobbaert, Johan W de Fijter
BACKGROUND: Urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP7) have been validated as biomarkers for acute kidney injury. We investigated the performance of both markers in predicting the occurrence and duration of functionally defined delayed graft function (fDGF) in donation after circulatory death (DCD) kidney transplant recipients. METHODS: Urine samples of 74 DCD recipients were analyzed. TIMP-2 and IGFBP7 were measured with ELISA on postoperative day 1 to 7, day 10, week 6 and month 6 and values were corrected for osmolality (mOsm)...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300281/everyday-people-sing-a-simple-song-establishing-a-core-outcome-for-life-participation
#11
Amtul Aala, Daniel C Brennan
No abstract text is available yet for this article.
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30300280/emerging-ethical-challenges-raised-by-the-evolution-of-vascularized-composite-allotransplantation
#12
Arthur L Caplan, Brendan Parent, Jeffrey Kahn, Wendy Dean, Laura L Kimberly, W P Andrew Lee, Eduardo D Rodriguez
BACKGROUND: Despite early skepticism, the field of vascularized composite allotransplantation (VCA) has demonstrated feasibility. The ethics of VCA have moved past doubts about the morality of attempting such transplant to how to conduct them ethically. METHODS: Leaders of each program performing and/or evaluating VCA in the United States were invited to participate in a working group to assess the state and future of VCA ethics and policy. Four meetings were held over the course of 1 year to describe key challenges and potential solutions...
October 8, 2018: Transplantation
https://www.readbyqxmd.com/read/30299375/do-we-need-noninvasive-biomarkers-for-delayed-graft-function-after-kidney-transplantation
#13
Elisabet Van Loon, Maarten Naesens
No abstract text is available yet for this article.
October 6, 2018: Transplantation
https://www.readbyqxmd.com/read/30299374/perfusion-of-porcine-kidneys-with-macromolecular-heparin-reduces-early-ischemia-reperfusion-injury
#14
Amir Sedigh, Sofia Nordling, Fredrik Carlsson, Erik Larsson, Bo Norlin, Norbert Lübenow, Fredrik Lennmyr, Gunnar Tufveson, Peetra U Magnusson, Tomas Lorant
BACKGROUND: Previously we have been able to demonstrate the possibility of coating the inner surface of the renal arteries in porcine kidneys with a heparin conjugate during hypothermic machine perfusion (HMP). The purpose of this study was to assess the efficacy of this treatment in reducing early ischemia-reperfusion injury. METHOD: Brain death was induced in male landrace pigs by stepwise volume expansion of an epidural balloon catheter until negative cerebral perfusion pressure was obtained...
October 6, 2018: Transplantation
https://www.readbyqxmd.com/read/30278018/label-free-identification-of-antibody-mediated-rejection-in-cardiac-allograft-biopsies-using-infrared-spectroscopic-imaging
#15
Imran Uraizee, Vishal K Varma, Hari Sreedhar, Francesca Gambacorta, Shaiju Nazeer, Aliya Husain, Michael J Walsh
BACKGROUND: Antibody-mediated rejection (AMR) in cardiac allograft recipients remains less well-understood than acute cellular rejection, is associated with worse outcomes, and portends a greater risk of developing chronic allograft vasculopathy. Diffuse immunohistochemical (IHC) C4d staining of capillary endothelia in formalin-fixed, paraffin-embedded (FFPE) right ventricular (RV) endomyocardial biopsies is diagnostic of immunopathologic AMR but serves more as a late-stage marker. Infrared (IR) spectroscopy may be a useful tool in earlier detection of rejection...
October 1, 2018: Transplantation
https://www.readbyqxmd.com/read/30273236/the-effect-of-the-opioid-epidemic-on-donation-after-cardiac-death-transplantation-outcomes
#16
Kerollos Nashat Wanis, Arin L Madenci, M Katherine Dokus, Koji Tomiyama, Bandar M Al-Judaibi, Miguel A Hernán, Roberto Hernandez-Alejandro
BACKGROUND: The opioid abuse epidemic and the deaths of otherwise healthy individuals due to drug overdose in the United States has major implications for transplantation. The current extent and safety of utilization of liver and kidney grafts from donation after cardiac death (DCD) donors who died in the context of opioid overdose is unknown. METHODS: Using national data from 2006 to 2016, we estimated the cumulative incidence of graft failure for recipients of DCD grafts, comparing the risk amongst recipients of organs from donors who died of anoxic drug overdose and recipients of organs from donors who died of other causes...
September 28, 2018: Transplantation
https://www.readbyqxmd.com/read/30273235/kaposi-sarcoma-in-hiv-positive-solid-organ-transplant-recipients-a-french-multicentric-national-study-and-literature-review
#17
Charpentier Chloé, Delyon Julie, Glotz Denis, Peraldi Marie-Noelle, Rerolle Jean-Philippe, Barrou Benoît, Ducroux Emilie, Coilly Audrey, Legeai Camille, Barete Stéphane, Lebbé Céleste
BACKGROUND: Kaposi sarcoma is a vascular tumor related to herpesvirus-8 and is promoted by immunosuppression. For the last 15 years, HIV patients have had access to organ transplantation. The dual immunosuppression of HIV and immunosuppressive treatments might increase the risk and severity of Kaposi sarcoma. METHODS: We conducted a multicentric retrospective study by collecting cases from French databases and society members of transplanted patients, among which 7 HIV-infected patients who subsequently developed Kaposi sarcoma were included...
September 28, 2018: Transplantation
https://www.readbyqxmd.com/read/30247449/early-hypertension-and-diabetes-after-living-kidney-donation-a-national-cohort-study
#18
Courtenay M Holscher, Sunjae Bae Kmd, Alvin G Thomas, Macey L Henderson, Christine E Haugen, Sandra R DiBrito, Abimereki D Muzaale, Jacqueline M Garonzik Wang, Allan B Massie, Krista L Lentine, Dorry L Segev
BACKGROUND: Living kidney donors have an increased risk of end-stage renal disease, with hypertension and diabetes as the predominant causes. In this study, we sought to better understand the timeline when these diseases occur, focusing on the early postdonation period. METHODS: We studied 41 260 living kidney donors in the US between 2008-2014 from the SRTR and modeled incidence rates and risk factors for hypertension and diabetes. RESULTS: At 6-months, 1-year, and 2-years postdonation, there were 74, 162, and 310 cases of hypertension per 10 000 donors...
September 21, 2018: Transplantation
https://www.readbyqxmd.com/read/30247448/donor-hypothermia-and-heart-transplantation
#19
Peter Schnuelle, Urs Benck, Bernhard K Krämer
No abstract text is available yet for this article.
September 21, 2018: Transplantation
https://www.readbyqxmd.com/read/30247447/the-challenges-associated-with-a-calcineurin-inhibitor-free-regimen-after-heart-transplantation
#20
Helio Tedesco Silva
No abstract text is available yet for this article.
September 21, 2018: Transplantation
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