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Dominik Chittka
No abstract text is available yet for this article.
November 30, 2018: Transplantation
Seong Jae Yeo, Ki Tae Kwon, Eun Soo Kim, Min Kyu Jung, Sung Kook Kim, Hyun Seok Lee, Jun Seop Lee, Sang Won Lee, Sang Gyu Kwak, Yoo Jin Lee, Seungyeup Han
BACKGROUND: Cytomegalovirus (CMV) is a common viral pathogen in transplant patients that often targets the stomach. However, the endoscopic characteristics of gastric CMV infection are not well established. We aimed to develop a predictive model using endoscopic findings for gastric CMV infection in renal transplant patients. METHODS: A retrospective study of 287 kidney transplant recipients who underwent endoscopy with biopsy for suspected CMV infection from Jan...
November 30, 2018: Transplantation
Michael Kriss, Elizabeth C Verna, Hugo R Rosen, Catherine A Lozupone
Gut dysbiosis, defined as a maladaptive gut microbial imbalance, has been demonstrated in patients with end-stage liver disease (ESLD), defined as a contributor to disease progression, and associated clinically with severity of disease and liver-related morbidity and mortality. Despite this well recognized phenomena in patients with ESLD, the impact of gut dysbiosis and its rate of recovery following liver transplantation (LT) remains incompletely understood. The mechanisms by which alterations in the gut microbiota impact allograft metabolism and immunity, both directly and indirectly, are multifactorial and reflect the complexity of the gut-liver axis...
November 30, 2018: Transplantation
Sandesh Parajuli, Emily Joachim, Sayee Alagusundaramoorthy, Justin Blazel, Fahad Aziz, Neetika Garg, Brenda Muth, Maha Mohamed, Didier Mandelbrot, Weixong Zhong, Arjang Djamali
BACKGROUND: Antibody-mediated rejection (ABMR) is a leading cause of morbidity and mortality after kidney transplantation. Early diagnosis and treatment of subclinical ABMR based on the donor-specific antibody (DSA) testing may result in better outcomes. METHODS: We tested this hypothesis in 220 kidney transplant recipients who underwent an indication or DSA-based surveillance protocol biopsies between 03/01/2013 and 12/31/2016. Patients were divided into three groups: clinical ABMR (n=118), subclinical ABMR (n=25), or no rejection on protocol biopsy (controls) (n=77)...
November 30, 2018: Transplantation
Jacob de Boer, Andries Braat, Hein Putter, Erwin de Vries, Christian H Strassburg, Zoltán Máthé, Bart van Hoek, Felix Braun, Aad van den Berg, Danko Mikulic, Peter Michielsen, Blaz Trotovsek, Heinz Zoller, Jan de Boer, Marieke van Rosmalen, Undine Samuel, Gabriela Berlakovich, Markus Guba
BACKGROUND: About 15% of liver transplantations in Eurotransplant are currently performed in patients with a high-urgency (HU) status. Patients that have acute liver failure or require an acute retransplantation can apply for this status. This study aims to evaluate the efficacy of this prioritization. METHODS: Patients that were listed for liver transplantation with HU status from 01.01.2007 up to 31.12.2015 were included. Waiting list and posttransplantation outcomes were evaluated and compared with a reference group of patients with labMELD scores ≥40 (MELD 40+)...
November 21, 2018: Transplantation
Mai Sato, Tetsuji Kaneko, Masao Ogura, Koichi Kamei, Shuichi Ito, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Kenji Ishikura
BACKGROUND: Although chronic kidney disease (CKD) is still a common complication, the prognosis of kidney function after LT is not well known. Moreover, kidney function after LT in children with renal involvement is unknown. METHODS: We retrospectively analyzed patients aged < 20 years who underwent LT between November 2005 and March 2015 at our institute. RESULTS: The cohort included 313 pediatric LT recipients (135 males). The median age at LT was 1...
November 21, 2018: Transplantation
Anusha S Shankar, Ewout J Hoorn, Joost Gribnau, Carla C Baan, Martin Hoogduijn
The worldwide increase in the number of end stage renal disease (ESRD) patients leads to a growing waiting list for kidney transplantation due to the scarcity of kidney donors. Therefore, alternative treatment options for patients with ESRD are being sought. In vitro differentiation of stem cells into renal tissue is a promising approach to repair non-functional kidney tissue. Impressive headway has been made in the use of stem cells with the use of adult renal progenitor cells (ARPCs), Embryonic Stem Cells (ESCs) and induced Pluripotent Stem Cells (iPSCs) for the development towards primitive kidney structures...
November 21, 2018: Transplantation
Yermek Nigmet, Koichiro Hata, Ichiro Tamaki, Yusuke Okamura, Tatsuaki Tsuruyama, Hidetaka Miyauchi, Jiro Kusakabe, Tetsuya Tajima, Hirofumi Hirao, Toyonari Kubota, Osamu Inamoto, Junichi Yoshikawa, Toru Goto, Hirokazu Tanaka, Shinji Uemoto
BACKGROUND: Current critical shortage of donor organs has increased the use of donation after circulatory death (DCD) livers for transplantation, despite higher risk for primary non-function or ischemic cholangiopathy. Human atrial natriuretic peptide (hANP) is a cardiovascular hormone that possesses protective action to vascular endothelia. We aimed to clarify the therapeutic potential of hANP in cold storage of DCD livers. METHODS: Male Wistar rats were exposed to 30-minute warm ischemia in situ...
November 19, 2018: Transplantation
Marianne Samyn, Mark Davenport, Vandana Jain, Nedim Hadzic, Deepak Joshi, Michael Heneghan, Anil Dhawan, Nigel Heaton
BACKGROUND: Young people born with biliary atresia are an emerging population for adult hepatologists with 40-45% of children entering adolescence with their native liver intact. For those requiring liver transplantation during adolescence, disparity on the waiting list and post liver transplantation outcome for young adults compared to younger and older age groups has stimulated discussion regarding the optimal timing of listing. In this study we review our experience of young people with biliary atresia requiring liver transplantation during adolescence and young adulthood...
November 19, 2018: Transplantation
Eleonora De Martin, Amelia Hessheimer, Ryan Chadha, Gokhan Kabacam, Jeremy Raganayagam, Varvara Kirchner, Marit Kalisvaart, Irene Scalera, Mamatha Bhat, Alan Contreras, Prashant Bhangui
The 24 Joint Annual Congress of the International Liver Transplantation Society (ILTS) in association with European Liver and Intestine Transplant Association (ELITA) and Liver Intensive Care Group of Europe (LICAGE) was held in Lisbon, Portugal from May 23-26, 2018. More than 1200 participants from over 60 countries including surgeons, hepatologists, anesthesiologists and critical care intensivists, radiologists, pathologists, organ procurement personnel and research scientists, came together with the common aim of improving care and outcomes for liver transplant recipients...
November 19, 2018: Transplantation
Daniel R Calabrese
No abstract text is available yet for this article.
November 19, 2018: Transplantation
Christopher M Harpur, Sanda Stankovic, Abbie Kanagarajah, Jacqueline M L Widjaja, Bronwyn J Levvey, Yvonne Cristiano, Greg I Snell, Andrew G Brooks, Glen P Westall, Lucy C Sullivan
BACKGROUND: In lung transplant recipients, immunosuppressive medications result in impaired antiviral immunity and a propensity for cytomegalovirus (CMV) reactivation within the lung allograft. Natural Killer (NK) cells play a key role in immunity to CMV, with an increase in the proportion of NK cells expressing activating CD94-NKG2C receptors in the blood being a strong correlate of CMV infection. Whether a similar increase in NKG2C NK cells occurs in lung transplant recipients following CMV reactivation in the allograft and if such cells contribute to viral control, remains unclear...
November 19, 2018: Transplantation
Lut Berben, Sandra J Engberg, Anja Rossmeissl, Elisa J Gordon, Christiane Kugler, Arno Schmidt-Trucksäss, Mary-Lou Klem, Susan M Sereika, Paolo De Simone, Fabienne Dobbels, Sabina M De Geest
BACKGROUND: Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examined correlates and outcomes associated with low PA (i.e. not meeting individual study's definition of being physically active) following solid organ transplantation. METHODS: We searched PubMed, CINAHL, PsycINFO and EMBASE from inception to February 2016 to identify peer-reviewed data-based articles...
November 19, 2018: Transplantation
Therese Bittermann
No abstract text is available yet for this article.
November 19, 2018: Transplantation
Kamlesh Patel, Thomas B Smith, Desley Ah Neil, Alpesh Thakker, Yugo Tsuchiya, Ellen B Higgs, Nikolas J Hodges, Andrew R Ready, Jay Nath, Christian Ludwig
BACKGROUND: Supplemental oxygenation of the standard Hypothermic Machine Perfusion (HMP) circuit has the potential to invoke favourable changes in metabolism, optimising cadaveric organs prior to transplantation. METHODS: Eight pairs of porcine kidneys underwent 18 hours of either oxygenated (HMP/O2) or aerated (HMP/Air) HMP in a paired DCD model of transplantation. Circulating perfusion fluid was supplemented with the metabolic tracer universally labelled glucose ([U-C] glucose)...
November 19, 2018: Transplantation
Yingchao Zhong, Douglas E Schaubel, John D Kalbfleisch, Valarie B Ashby, Panduranga S Rao, Randall S Sung
BACKGROUND: The Kidney Donor Risk Index (KDRI) is a score applicable to deceased kidney donors which reflects relative graft failure risk associated with deceased donor characteristics. The KDRI is widely used in kidney transplant outcomes research. Moreover, an abbreviated version of KDRI is the basis, for allocation purposes, of the "top 20%" designation for deceased donor kidneys. Data upon which the KDRI model was based used kidney transplants performed between 1995 and 2005...
November 16, 2018: Transplantation
Roberto Gedaly, Felice De Stefano, Lilia Turcios, Marita Hill, Giovanna Hidalgo, Mihail I Mitov, Michael C Alstott, D Allan Butterfield, Hunter C Mitchell, Jeremy Hart, Ahmad Al-Attar, Chester D Jennings, Francesc Marti
BACKGROUND: Experimental and pre-clinical evidence suggest that adoptive transfer of regulatory T cells (Tregs) could be an appropriate therapeutic strategy to induce tolerance and improve graft survival in transplanted patients. The University of Kentucky Transplant Service Line is developing a novel Phase I/II clinical trial with ex vivo expanded autologous Tregs as an adoptive cellular therapy in renal transplant recipients who are using everolimus (EVR)-based immunosuppressive regimen...
November 16, 2018: Transplantation
Nancy L Ascher, Francis L Delmonico
No abstract text is available yet for this article.
November 16, 2018: Transplantation
Alexandra Shingina, Peter E DeWitt, Jennifer L Dodge, Scott W Biggins, Jane Gralla, David Sprague, Kiran Bambha
BACKGROUND: With increasing U.S. adiposity, NASH is now a leading liver transplant (LT) indication. Given its association with hepatocellular carcinoma (HCC), the burden of NASH is substantial. We analyzed birth-cohort effects among NASH LT registrants, with and without HCC. METHODS: All new LT registrants in UNOS (1995-2015) were identified. Birth-cohorts were: 1936-1940, 1941-1945, 1946-1950, 1951-1955, 1956-1960, 1961-1965, 1966-1970, 1971-2015. Poisson regression examined trends in LT registration, by disease etiology (NASH, HCV, OTHER), and HCC...
November 16, 2018: Transplantation
Bernd Schröppel, Peter Heeger, H Thiessen-Philbrook, Isaac E Hall, Mona D Doshi, Francis L Weng, Peter P Reese, Chirag R Parikh
BACKGROUND: Accumulating evidence implicates the complement cascade as pathogenically contributing to ischemia-reperfusion injury and delayed graft function (DGF) in human kidney transplant recipients. Building upon observations that kidney injury can initiate in the donor before nephrectomy, we tested the hypothesis that anaphylatoxins C3a and C5a in donor urine prior to transplantation associate with risk of post-transplant injury. METHODS: We evaluated the effects of C3a and C5a in donor urine on outcomes of 469 deceased donors and their corresponding 902 kidney recipients in a subset of a prospective cohort study...
November 16, 2018: Transplantation
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