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Thorax

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https://www.readbyqxmd.com/read/27927841/visual-identification-of-pulmonary-ventilation-and-perfusion-a-new-application-of-lung-ultrasound
#1
Guido Tavazzi, Francisca Ana Caetano, Sachin Shah, Joana Alcada, Susanna Price
No abstract text is available yet for this article.
December 7, 2016: Thorax
https://www.readbyqxmd.com/read/27927840/%C3%AE-blockers-heart-disease-and-copd-current-controversies-and-uncertainties
#2
Jillian G Baker, Robert G Wilcox
Treating people with cardiovascular disease and COPD causes significant clinician anxiety. β-Blockers save lives in people with heart disease, specifically postinfarction and heart failure. COPD and heart disease frequently coexist and people with both disorders have particularly high cardiovascular mortality. There are concerns about giving β-blockers to people with concomitant COPD that include reduced basal lung function, diminished effectiveness of emergency β-agonist treatments, reduced benefit of long-acting β-agonist treatment and difficulty in discriminating between asthma and COPD...
December 7, 2016: Thorax
https://www.readbyqxmd.com/read/27920335/prevention-of-sudden-cardiac-death-by-the-wearable-cardioverter-defibrillator-in-a-young-patient-with-cardiac-sarcoidosis
#3
René Andrié, Florian C Gaertner, Dirk Skowasch
No abstract text is available yet for this article.
December 5, 2016: Thorax
https://www.readbyqxmd.com/read/27913769/macroscopic-inflammatory-tracheal-and-endobronchial-nodules-in-sj%C3%A3-gren-s-syndrome
#4
Hiromichi Hara, Kazuyoshi Kuwano, Shunsuke Minagawa, Takanori Numata, Jun Araya, Katsutoshi Nakayama
No abstract text is available yet for this article.
December 2, 2016: Thorax
https://www.readbyqxmd.com/read/27913768/do-farm-grown-lungs-breathe-better
#5
EDITORIAL
Jon Genuneit, Erika von Mutius
No abstract text is available yet for this article.
December 2, 2016: Thorax
https://www.readbyqxmd.com/read/27913767/-turban-like-skull-metastasis-from-pulmonary-adenocarcinoma
#6
Maria Cecilia Mengoli, Giulio Rossi, Marcello Tiseo, Fausto Barbieri, Micol Pifferi, Federica Bertolini, Filippo Lococo
No abstract text is available yet for this article.
December 2, 2016: Thorax
https://www.readbyqxmd.com/read/27885167/mortality-from-respiratory-diseases-associated-with-opium-use-a-population-based-cohort-study
#7
Atieh Rahmati, Ramin Shakeri, Hooman Khademi, Hossein Poutschi, Akram Pourshams, Arash Etemadi, Masoud Khoshnia, Amir Ali Sohrabpour, Ali Aliasgari, Elham Jafari, Farhad Islami, Shahryar Semnani, Abdolsamad Gharravi, Christian C Abnet, Paul D P Pharoah, Paul Brennan, Paolo Boffetta, Sanford M Dawsey, Reza Malekzadeh, Farin Kamangar
BACKGROUND: Recent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data. METHODS: We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27885166/the-role-of-interleukin-33-in-chronic-rhinosinusitis
#8
Dong-Kyu Kim, Hong Ryul Jin, Kyoung Mi Eun, Ji-Hun Mo, Seong H Cho, Sohee Oh, David Cho, Dae Woo Kim
RATIONALE: Interleukin (IL)-33, a new member of the IL-1 family, is constitutively expressed in epithelial tissues and lymphoid organs and plays an important role in the pathogenesis of allergic disease. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. OBJECTIVE: To investigate the role of IL-33 in the pathophysiology of CRSwNP. METHODS: We investigated IL-33 expression and its cellular origins in the nasal polyps (NPs) of human subjects by immunohistochemistry (IHC), quantitative reverse transcription PCR (qRT-PCR), and multiplex cytokine assays...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27879416/occupational-pesticide-exposure-and-respiratory-health-a-large-scale-cross-sectional-study-in-three-commercial-farming-systems-in-ethiopia
#9
Beyene Negatu, Hans Kromhout, Yalemtshay Mekonnen, Roel Vermeulen
RATIONALE: In the last decade, due to expansion of greenhouses and irrigated farms, the use of pesticides in Ethiopia has increased 6-13-fold leading to potential health risks. OBJECTIVE: To investigate if occupational exposure to pesticides is associated with respiratory health effects in farmers and farm workers from commercial farming systems. METHODS: We performed two cross-sectional surveys comprising different farming systems. In the first survey we studied respiratory symptoms among 1104 subjects of which 601 were occupationally exposed to pesticides (ie, 256 pesticide applicators, 345 re-entry workers) and 503 unexposed individuals...
November 22, 2016: Thorax
https://www.readbyqxmd.com/read/27872320/pott-s-disease-a-major-issue-for-an-unaccompanied-refugee-minor
#10
Cihan Papan, Ulrich von Both, Matthias Kappler, Birgit Kammer, Matthias Griese, Johannes Huebner
The incidence of TB in children in Germany has been on a rise since 2008, especially among foreign-born individuals. With rapidly increasing numbers of refugees from the numerous areas of conflict, this increase in incidence is not expected to halt, neither in Germany nor in Europe in general. We report a case of insufficient tracking in a 16-year-old unaccompanied refugee minor from Somalia who had a positive interferon γ release assay on arrival in Germany. No actions were undertaken, until 6 months later, an X-ray showed prominent hilar enlargement...
November 21, 2016: Thorax
https://www.readbyqxmd.com/read/27856821/determinants-of-early-life-lung-function-in-african-infants
#11
Diane Gray, Lauren Willemse, Ane Visagie, Dorottya Czövek, Polite Nduru, Aneesa Vanker, Dan J Stein, Nastassja Koen, Peter D Sly, Zoltán Hantos, Graham L Hall, Heather J Zar
BACKGROUND: Low lung function in early life is associated with later respiratory illness. There is limited data on lung function in African infants despite a high prevalence of respiratory disease. AIM: To assess the determinants of early lung function in African infants. METHOD: Infants enrolled in a South African birth cohort, the Drakenstein child health study, had lung function measured at 6-10 weeks of age. Measurements, made with the infant breathing via a facemask during natural sleep, included tidal breathing, sulfur hexafluoride multiple breath washout and the forced oscillation technique...
November 17, 2016: Thorax
https://www.readbyqxmd.com/read/27852957/cementing-an-unwanted-relationship
#12
Chia-Hao Chang, Li-Ta Keng, Jen-Chung Ko
No abstract text is available yet for this article.
November 16, 2016: Thorax
https://www.readbyqxmd.com/read/27852956/preparation-for-a-first-in-man-lentivirus-trial-in-patients-with-cystic-fibrosis
#13
Eric W F W Alton, Jeffery M Beekman, A Christopher Boyd, June Brand, Marianne S Carlon, Mary M Connolly, Mario Chan, Sinead Conlon, Heather E Davidson, Jane C Davies, Lee A Davies, Johanna F Dekkers, Ann Doherty, Sabrina Gea-Sorli, Deborah R Gill, Uta Griesenbach, Mamoru Hasegawa, Tracy E Higgins, Takashi Hironaka, Laura Hyndman, Gerry McLachlan, Makoto Inoue, Stephen C Hyde, J Alastair Innes, Toby M Maher, Caroline Moran, Cuixiang Meng, Michael C Paul-Smith, Ian A Pringle, Kamila M Pytel, Andrea Rodriguez-Martinez, Alexander C Schmidt, Barbara J Stevenson, Stephanie G Sumner-Jones, Richard Toshner, Shu Tsugumine, Marguerite W Wasowicz, Jie Zhu
We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors are more efficient for lung gene transfer than non-viral vectors in preclinical models. In preparation for a first-in-man CF trial using the lentiviral vector, we have undertaken key translational preclinical studies...
November 16, 2016: Thorax
https://www.readbyqxmd.com/read/27852955/microbiological-efficacy-of-early-mrsa-treatment-in-cystic-fibrosis-in-a-randomised-controlled-trial
#14
Marianne Sponer Muhlebach, Valeria Beckett, Elena Popowitch, Melissa B Miller, Arthur Baines, Nicole Mayer-Hamblett, Edith T Zemanick, Wynton C Hoover, Jill M VanDalfsen, Preston Campbell, Christopher H Goss
OBJECTIVE: To evaluate microbiological effectiveness, that is, culture negativity of a non-blinded eradication protocol (Rx) compared with observation (Obs) in clinically stable cystic fibrosis participants with newly positive methicillin resistant Staphylococcus aureus (MRSA) cultures. DESIGN: This non-blinded trial randomised participants ages 4-45 years with first or early (≤2 positive cultures within 3 years) MRSA-positive culture without MRSA-active antibiotics within 4 weeks 1:1 to Rx or Obs...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27852954/intralobular-septal-thickening-on-chest-ct-in-a-patient-with-pulmonary-amyloidosis-a-rare-case-study
#15
Yasuhito Suzuki, Junpei Saito, Ryuichi Togawa, Hiroyuki Minemura, Mitsuru Munakata
No abstract text is available yet for this article.
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27852953/effectiveness-of-an-exercise-programme-on-physical-function-in-patients-discharged-from-hospital-following-critical-illness-a-randomised-controlled-trial-the-revive-trial
#16
Kathryn McDowell, Brenda O'Neill, Bronagh Blackwood, Chris Clarke, Evie Gardner, Paul Johnston, Michaeline Kelly, John McCaffrey, Brian Mullan, Sally Murphy, T John Trinder, Gavin Lavery, Daniel F McAuley, Judy M Bradley
OBJECTIVE: To investigate the effectiveness of a 6-week exercise programme in patients discharged home following critical illness compared with standard care. DESIGN: Multicentre prospective phase II randomised controlled trial, with blinded outcome assessment after hospital discharge, following the 6-week intervention and at 6 months. PARTICIPANTS: 60 patients (30 per group) aged ≥18 years, mechanically ventilated >96 hours, and not in other rehabilitation, that is, cardiac or pulmonary rehabilitation programmes...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27852952/a-randomised-controlled-trial-of-cpap-versus-non-invasive-ventilation-for-initial-treatment-of-obesity-hypoventilation-syndrome
#17
Mark E Howard, Amanda J Piper, Bronwyn Stevens, Anne E Holland, Brendon J Yee, Eli Dabscheck, Duncan Mortimer, Angela T Burge, Daniel Flunt, Catherine Buchan, Linda Rautela, Nicole Sheers, David Hillman, David J Berlowitz
BACKGROUND: Obesity hypoventilation syndrome (OHS) is the most common indication for home ventilation, although the optimal therapy remains unclear, particularly for severe disease. We compared Bi-level and continuous positive airways pressure (Bi-level positive airway pressure (PAP); CPAP) for treatment of severe OHS. METHODS: We conducted a multicentre, parallel, double-blind trial for initial treatment of OHS, with participants randomised to nocturnal Bi-level PAP or CPAP for 3 months...
November 15, 2016: Thorax
https://www.readbyqxmd.com/read/27821722/taming-chronic-cough
#18
EDITORIAL
Jaclyn A Smith, Jemma Haines, Janelle Yorke
No abstract text is available yet for this article.
November 7, 2016: Thorax
https://www.readbyqxmd.com/read/27815524/staar-a-randomised-controlled-trial-of-electronic-adherence-monitoring-with-reminder-alarms-and-feedback-to-improve-clinical-outcomes-for-children-with-asthma
#19
Robert W Morton, Heather E Elphick, Alan S Rigby, William J Daw, David A King, Laurie J Smith, Mark L Everard
BACKGROUND: Suboptimal adherence to inhaled steroids is common in children with asthma and is associated with poor disease control, reduced quality of life and even death. Previous studies using feedback of electronically monitored adherence data have demonstrated improved adherence, but have not demonstrated a significant impact on clinical outcomes. The aim of this study was to determine whether introduction of this approach into routine practice would result in improved clinical outcomes...
November 4, 2016: Thorax
https://www.readbyqxmd.com/read/27815523/histologist-s-original-opinion-compared-with-multidisciplinary-team-in-determining-diagnosis-in-interstitial-lung-disease
#20
LETTER
P S Burge, J Reynolds, S Trotter, G A Burge, G Walters
Guidelines recommend that multidisciplinary interstitial lung disease meeting (ILD MDT) decisions become the gold standard for diagnosis, replacing the histologist from this position, and identify this as requiring supportive evidence. We have compared diagnoses from lung biopsy material made by expert histologists with the subsequent consensus opinion from a properly constituted ILD MDT in 71 consecutive patients referred to a regional thoracic unit. MDT changed the original histological diagnoses in 30% (95% CI 19...
November 4, 2016: Thorax
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