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Thorax

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https://www.readbyqxmd.com/read/29222094/case-based-discussion-from-the-neonatal-intensive-care-unit-a-case-of-an-intentional-oesophageal-intubation
#1
Katharine Jamieson, Stephanie Boyd, Susern Tan, Davina Wong, Paul James, Andrew Durward, Andrew Nyman
Tracheal agenesis (TA) is a rare congenital defect consisting of complete or partial absence of the trachea below the larynx. Antenatal diagnosis is challenging, and most cases are detected in the postnatal period. Airway management of such cases, particularly in the absence of antenatal diagnosis, can be challenging. Various methods of management have been described but with limited success, and overall prognosis remains very poor. We present an unexpected case of TA, highlighting management issues and diagnostic methods...
December 8, 2017: Thorax
https://www.readbyqxmd.com/read/29212668/unexpected-migration
#2
Gayatri Raghuram, Dipak Mukherjee, Kanwar Pannu, Sudhir Bhusari
No abstract text is available yet for this article.
December 6, 2017: Thorax
https://www.readbyqxmd.com/read/29212667/lung-tissue-gene-expression-signature-for-the-ageing-lung-in-copd
#3
Maaike de Vries, Alen Faiz, Roy R Woldhuis, Dirkje S Postma, Tristan V de Jong, Don D Sin, Yohan Bossé, David C Nickle, Victor Guryev, Wim Timens, Maarten van den Berge, Corry-Anke Brandsma
INTRODUCTION: COPD is a chronic, progressive, inflammatory disease of the lungs and the third leading cause of death worldwide. The current knowledge of the pathophysiology of COPD is limited and novel insights in underlying disease mechanisms are urgently needed. Since there are clear parallels between ageing and COPD, we investigated genes underlying lung ageing in general and abnormal lung ageing in COPD. METHODS: Whole genome mRNA profiling was performed on lung tissue samples (n=1197) and differential gene expression with increasing age was analysed using an adjusted linear regression model...
December 6, 2017: Thorax
https://www.readbyqxmd.com/read/29196470/endobronchial-epithelial-myoepithelial-carcinoma-of-the-lung
#4
Chang Hoon Kim, Jae Seok Jeong, So Ri Kim, Yong Chul Lee
No abstract text is available yet for this article.
December 1, 2017: Thorax
https://www.readbyqxmd.com/read/29187594/plasma-urate-lung-function-and-chronic-obstructive-pulmonary-disease-a-mendelian-randomisation-study-in-114-979-individuals-from-the-general-population
#5
Camilla J Kobylecki, Signe Vedel-Krogh, Shoaib Afzal, Sune F Nielsen, Børge G Nordestgaard
BACKGROUND: Urate is a strong antioxidant in plasma and may protect against lung function impairment. We tested the hypothesis that high plasma urate is causally associated with better lung function and low risk of respiratory symptoms and COPD. METHODS: We measured lung function and plasma urate in 114 979 individuals from the Copenhagen City Heart Study and the Copenhagen General Population Study and genotyped for SLC2A9 rs7442295 and ABCG2 rs2231142 variants, previously associated with high plasma urate, in 110 152 individuals...
November 29, 2017: Thorax
https://www.readbyqxmd.com/read/29187593/ghost-of-chest-drain-past
#6
Freddy Frost, James Hare, John Holemans, Martin Walshaw
No abstract text is available yet for this article.
November 29, 2017: Thorax
https://www.readbyqxmd.com/read/29187592/heterogeneity-of-respiratory-disease-in-children-and-young-adults-with-sickle-cell-disease
#7
Alan Lunt, Lucy Mortimer, David Rees, Sue Height, Swee Lay Thein, Anne Greenough
To detect and characterise different phenotypes of respiratory disease in children and young adults with sickle cell disease (SCD), 11 lung function and haematological biomarkers were analysed using k-means cluster analysis in a cohort of 114 subjects with SCD aged between 5 and 27 years. Three clusters were detected: cluster 1 had elevated pulmonary capillary blood volume, mixed obstructive/restrictive lung disease, hypoxia and moderately severe anaemia; cluster 2 were older patients with restrictive lung disease; and cluster 3 were younger patients with obstructive lung disease, elevated serum lactate dehydrogenase and bronchodilator reversibility...
November 29, 2017: Thorax
https://www.readbyqxmd.com/read/29170249/lower-respiratory-infections-in-early-life-are-linked-to-later-asthma
#8
EDITORIAL
Theo J Moraes, Malcolm R Sears
No abstract text is available yet for this article.
November 23, 2017: Thorax
https://www.readbyqxmd.com/read/29150549/psychometric-validation-of-the-needs-assessment-tool-progressive-disease-in-interstitial-lung-disease
#9
Miriam J Johnson, Armita Jamali, Joy Ross, Caroline Fairhurst, Jason Boland, Carla Reigada, Simon Paul Hart, Gunn Grande, David C Currow, Athol U Wells, Sabrina Bajwah, Thanos Papadopoulos, J Martin Bland, Janelle Yorke
The inter-rater/test-retest reliability and construct validity of a palliative care needs assessment tool in interstitial lung disease (NAT:PD-ILD) were tested using NAT:PD-ILD-guided video-recorded consultations, and NAT:PD-ILD-guided consultations, and patient and carer-report outcomes (St George's Respiratory Questionnaire (SGRQ)-ILD, Carer Strain Index (CSI)/Carer Support Needs Assessment Tool (CSNAT)). 11/16 items reached at least fair inter-rater agreement; 5 items reached at least moderate test-retest agreement...
November 17, 2017: Thorax
https://www.readbyqxmd.com/read/29146867/high-prevalence-of-tb-disease-in-contacts-of-adults-with-extrapulmonary-tb
#10
Tom Wingfield, Peter MacPherson, Paul Cleary, L Peter Ormerod
UK guidelines no longer recommend routine screening of household contacts of adult patients with extrapulmonary TB (EPTB). From 27 March 2012 to 28 June 2016, we investigated the prevalence of active TB disease in household contacts of 1023 EPTB index cases in North West England, and compared estimates with: published new entrant migrant screening programme prevalence (~147/100 000 person-years); London-based contact screening data (700/100 000 contacts screened); and National Institute for Health and Care Excellence (NICE) new entrant TB screening thresholds (TB prevalence >40/100 000 people)...
November 16, 2017: Thorax
https://www.readbyqxmd.com/read/29146866/higher-altitude-bigger-bulla
#11
Xian-Ning Wu, Dan Su, Xiao-Feng Zhu, Mei-Qing Xu
No abstract text is available yet for this article.
November 16, 2017: Thorax
https://www.readbyqxmd.com/read/29146865/echocardiographic-changes-with-non-invasive-ventilation-and-cpap-in-obesity-hypoventilation-syndrome
#12
Jaime Corral, Maria Victoria Mogollon, M-Ángeles Sánchez-Quiroga, Javier Gómez de Terreros, Auxiliadora Romero, Candela Caballero, Joaquin Teran-Santos, María L Alonso-Álvarez, Teresa Gómez-García, Mónica González, Soledad López-Martínez, Pilar de Lucas, José M Marin, Odile Romero, Trinidad Díaz-Cambriles, Eusebi Chiner, Carlos Egea, Roberto M Lang, Babak Mokhlesi, Juan F Masa
RATIONALE: Despite a significant association between obesity hypoventilation syndrome (OHS) and cardiac dysfunction, no randomised trials have assessed the impact of non-invasive ventilation (NIV) or CPAP on cardiac structure and function assessed by echocardiography. OBJECTIVES: We performed a secondary analysis of the data from the largest multicentre randomised controlled trial of OHS (Pickwick project, n=221) to determine the comparative efficacy of 2 months of NIV (n=71), CPAP (n=80) and lifestyle modification (control group, n=70) on structural and functional echocardiographic changes...
November 16, 2017: Thorax
https://www.readbyqxmd.com/read/29138262/a-big-beautiful-wall-against-infection
#13
Gisli Jenkins
No abstract text is available yet for this article.
November 14, 2017: Thorax
https://www.readbyqxmd.com/read/29138261/hindsight-and-moving-the-needle-forwards-on-rehabilitation-trial-design
#14
EDITORIAL
Bronwen Connolly, Linda Denehy
No abstract text is available yet for this article.
November 14, 2017: Thorax
https://www.readbyqxmd.com/read/29133352/primary-ciliary-dyskinesia-keep-it-on-your-radar
#15
EDITORIAL
Margaret Rosenfeld, Lawrence E Ostrowski, Maimoona A Zariwala
No abstract text is available yet for this article.
November 13, 2017: Thorax
https://www.readbyqxmd.com/read/29133351/efficacy-and-safety-outcomes-of-recanalisation-procedures-in-patients-with-acute-symptomatic-pulmonary-embolism-systematic-review-and-network-meta-analysis
#16
David Jimenez, Carlos Martin-Saborido, Alfonso Muriel, Javier Zamora, Raquel Morillo, Deisy Barrios, Frederikus A Klok, Menno V Huisman, Victor Tapson, Roger D Yusen
BACKGROUND: We aimed to review the efficacy and safety of recanalisation procedures for the treatment of PE. METHODS: We searched PubMed, the Cochrane Library, EMBASE, EBSCO, Web of Science and CINAHL databases from inception through 31 July 2015 and included randomised clinical trials that compared the effect of a recanalisation procedure versus each other or anticoagulant therapy in patients diagnosed with PE. We used network meta-analysis and multivariate random-effects meta-regression to estimate pooled differences between each intervention and meta-regression to assess the association between trial characteristics and the reported effects of recanalisation procedures versus anticoagulation...
November 13, 2017: Thorax
https://www.readbyqxmd.com/read/29123018/aortic-rupture-involving-matrix-metalloproteinases-8-and-9-during-staphylococcus-aureus-pneumonia
#17
Mitsuo Hashimoto, Saki Kuriiwa, Ayako Kojima, Shunsuke Minagawa, Takanori Numata, Hiromichi Hara, Jun Araya, Yumi Kaneko, Katsutoshi Nakayama, Mamiko Owada, Daisuke Aizawa, Takashi Yorozu, Masafumi Suzuki, Kazuyoshi Kuwano
No abstract text is available yet for this article.
November 9, 2017: Thorax
https://www.readbyqxmd.com/read/29123017/benign-pleural-schwannoma-presenting-with-a-large-blood-stained-pleural-effusion
#18
Anna C Bibby, Richard Daly, Eveline Internullo, Anthony J Edey, Nicholas A Maskell
No abstract text is available yet for this article.
November 9, 2017: Thorax
https://www.readbyqxmd.com/read/29109233/advance-care-planning-for-patients-with-chronic-respiratory-diseases-a-systematic-review-of-preferences-and-practices
#19
Lea J Jabbarian, Marieke Zwakman, Agnes van der Heide, Marijke C Kars, Daisy J A Janssen, Johannes J van Delden, Judith A C Rietjens, Ida J Korfage
BACKGROUND: Advance care planning (ACP) supports patients in identifying and documenting their preferences and timely discussing them with their relatives and healthcare professionals (HCPs). Since the British Thoracic Society encourages ACP in chronic respiratory disease, the objective was to systematically review ACP practice in chronic respiratory disease, attitudes of patients and HCPs and barriers and facilitators related to engagement in ACP. METHODS: We systematically searched 12 electronic databases for empirical studies on ACP in adults with chronic respiratory diseases...
November 6, 2017: Thorax
https://www.readbyqxmd.com/read/29101284/genetic-mannose-binding-lectin-deficiency-is-associated-with-airway-microbiota-diversity-and-reduced-exacerbation-frequency-in-copd
#20
Alison J Dicker, Megan L Crichton, Andrew J Cassidy, Gill Brady, Adrian Hapca, Roger Tavendale, Gisli G Einarsson, Elizabeth Furrie, J Stuart Elborn, Stuart Schembri, Sara E Marshall, Colin N A Palmer, James D Chalmers
BACKGROUND: In cystic fibrosis and bronchiectasis, genetic mannose binding lectin (MBL) deficiency is associated with increased exacerbations and earlier mortality; associations in COPD are less clear. Preclinical data suggest MBL interferes with phagocytosis of Haemophilus influenzae, a key COPD pathogen. We investigated whether MBL deficiency impacted on clinical outcomes or microbiota composition in COPD. METHODS: Patients with COPD (n=1796) underwent MBL genotyping; linkage to health records identified exacerbations, lung function decline and mortality...
November 3, 2017: Thorax
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