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Thorax

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https://www.readbyqxmd.com/read/28331076/the-effect-of-different-radiological-models-on-diagnostic-accuracy-and-lung-cancer-screening-performance
#1
LETTER
Henry M Marshall, Henry Zhao, Rayleen V Bowman, Linda H Passmore, Elizabeth M McCaul, Ian A Yang, Kwun M Fong
High false-positive (FP) scan rates associated with low-dose computed tomography (LDCT) lung cancer screening result in unnecessary follow-up tests and exposure to harm. The definition of a 'positive' scan can impact FP rates and screening performance. We explored the effect of Lung Imaging Reporting and Data System (Lung-RADS) criteria, PanCan Nodule Malignancy Probability Model and varying nodule size thresholds (≥4 mm, ≥6 mm, ≥8 mm) on diagnostic accuracy and screening performance compared with original trial definitions (National Lung Screening Trial (NLST) criteria) in a secondary analysis of a lung cancer screening cohort...
March 22, 2017: Thorax
https://www.readbyqxmd.com/read/28320931/translating-genomics-into-risk-prediction
#2
EDITORIAL
Emily S Wan, Dawn L DeMeo
No abstract text is available yet for this article.
March 20, 2017: Thorax
https://www.readbyqxmd.com/read/28302749/-i-m-useless-after-a-bad-night-s-sleep-doctor-could-sleep-be-the-key-to-improving-physical-activity-in-people-with-copd
#3
EDITORIAL
Emma H Baker, Daniel R Burrage
No abstract text is available yet for this article.
March 16, 2017: Thorax
https://www.readbyqxmd.com/read/28292852/progress-in-disease-progression-genetics-dissecting-the-genetic-origins-of-lung-function-decline-in-copd
#4
EDITORIAL
Robert Busch, Michael H Cho, Edwin K Silverman
No abstract text is available yet for this article.
March 14, 2017: Thorax
https://www.readbyqxmd.com/read/28270535/thinking-outside-the-lungs-other-risk-factors-for-pneumonia-hospitalisation
#5
EDITORIAL
C I Bloom, J K Quint
No abstract text is available yet for this article.
March 7, 2017: Thorax
https://www.readbyqxmd.com/read/28270534/exercise-training-in-interstitial-lung-disease-lumping-or-splitting
#6
EDITORIAL
Katrina Curtis, Nicholas S Hopkinson
No abstract text is available yet for this article.
March 7, 2017: Thorax
https://www.readbyqxmd.com/read/28265033/do-patients-with-obstructive-sleep-apnoea-deserve-new-dedicated-antihypertensive-strategies
#7
EDITORIAL
Renaud Tamisier, Patrick Lévy, Jean-Louis Pépin
No abstract text is available yet for this article.
March 6, 2017: Thorax
https://www.readbyqxmd.com/read/28265032/detection-of-early-subclinical-lung-disease-in-children-with-cystic-fibrosis-by-lung-ventilation-imaging-with-hyperpolarised-gas-mri
#8
LETTER
Helen Marshall, Alex Horsley, Chris J Taylor, Laurie Smith, David Hughes, Felix C Horn, Andrew J Swift, Juan Parra-Robles, Paul J Hughes, Graham Norquay, Neil J Stewart, Guilhem J Collier, Dawn Teare, Steve Cunningham, Ina Aldag, Jim M Wild
Hyperpolarised (3)He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>-1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI...
March 6, 2017: Thorax
https://www.readbyqxmd.com/read/28265031/phage-therapy-is-highly-effective-against-chronic-lung-infections-with-pseudomonas-aeruginosa
#9
LETTER
Elaine M Waters, Daniel R Neill, Basak Kaman, Jaspreet S Sahota, Martha R J Clokie, Craig Winstanley, Aras Kadioglu
With an increase in cases of multidrug-resistant Pseudomonas aeruginosa, alternative and adjunct treatments are needed, leading to renewed interest in bacteriophage therapy. There have been few clinically relevant studies of phage therapy against chronic lung infections. Using a novel murine model that uses a natural respiratory inhalation route of infection, we show that phage therapy is an effective treatment against chronic P. aeruginosa lung infections. We also show efficacy against P. aeruginosa in a biofilm-associated cystic fibrosis lung-like environment...
March 6, 2017: Thorax
https://www.readbyqxmd.com/read/28258250/mri-ventilation-abnormalities-predict-quality-of-life-and-lung-function-changes-in-mild-to-moderate-copd-longitudinal-tincan-study
#10
LETTER
Miranda Kirby, Rachel L Eddy, Damien Pike, Sarah Svenningsen, Harvey O Coxson, Don D Sin, David G McCormack, Grace Parraga
: COPD biomarkers are urgently required for clinical trials of new therapies. We evaluated the longitudinal change and relationship of MRI and CT biomarkers of COPD with St. George's Respiratory Questionnaire (SGRO) and FEV1 worsening over 30 months. Among imaging biomarkers, only the longitudinal change in MRI ventilation defect percent (VDP) was greater in ever-smoker (n=34/p<0.05) and COPD (n=48/p<0.0001) subgroups compared with never-smokers (n=42). Only the longitudinal change in VDP was correlated with change in SGRQ (r=0...
March 3, 2017: Thorax
https://www.readbyqxmd.com/read/28258249/does-training-respiratory-physicians-in-clinical-respiratory-physiology-and-interpretation-of-pulmonary-function-tests-improve-core-knowledge
#11
LETTER
M Patout, L Sesé, T Gille, B Coiffard, S Korzeniewski, E Lhuillier, A Pradel, C Tardif, A Chambellan, C Straus, S Matecki, T Perez, L Thiberville, A Didier
Lung function tests have a major role in respiratory medicine. Training in lung function tests is variable within the European Union. In this study, we have shown that an internship in a lung function tests laboratory significantly improved the technical and diagnostic skills of French respiratory trainees.
March 3, 2017: Thorax
https://www.readbyqxmd.com/read/28250201/socio-environmental-correlates-of-physical-activity-in-patients-with-chronic-obstructive-pulmonary-disease-copd
#12
Ane Arbillaga-Etxarri, Elena Gimeno-Santos, Anael Barberan-Garcia, Marta Benet, Eulàlia Borrell, Payam Dadvand, Maria Foraster, Alicia Marín, Mònica Monteagudo, Robert Rodriguez-Roisin, Pere Vall-Casas, Jordi Vilaró, Judith Garcia-Aymerich
BACKGROUND: Study of the causes of the reduced levels of physical activity in patients with COPD has been scarce and limited to biological factors. AIM: To assess the relationship between novel socio-environmental factors, namely dog walking, grandparenting, neighbourhood deprivation, residential surrounding greenness and residential proximity to green or blue spaces, and amount and intensity of physical activity in COPD patients. METHODS: This cross-sectional study recruited 410 COPD patients from five Catalan municipalities...
March 1, 2017: Thorax
https://www.readbyqxmd.com/read/28250200/cxcl14-is-a-candidate-biomarker-for-hedgehog-signalling-in-idiopathic-pulmonary-fibrosis
#13
Guiquan Jia, Sanjay Chandriani, Alexander R Abbas, Daryle J DePianto, Elsa N N'Diaye, Murat B Yaylaoglu, Heather M Moore, Ivan Peng, Jason DeVoss, Harold R Collard, Paul J Wolters, Jackson G Egen, Joseph R Arron
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with aberrant expression of developmental pathways, including Hedgehog (Hh). As Hh signalling contributes to multiple pro-fibrotic processes, Hh inhibition may represent a therapeutic option for IPF. However, no non-invasive biomarkers are available to monitor lung Hh activity. METHODS: We assessed gene and protein expression in IPF and control lung biopsies, mouse lung, fibroblasts stimulated in vitro with sonic hedgehog (SHh), and plasma in IPF patients versus controls, and cancer patients before and after treatment with vismodegib, a Hh inhibitor...
March 1, 2017: Thorax
https://www.readbyqxmd.com/read/28246221/herpes-simplex-lesion-mimicking-left-upper-lobe-bronchial-tumour
#14
George Caldas Dantas, Hamilton Shoji, Cristiane Hoelz, Marcelo Buarque de Gusmão Funari, Gilberto Szarf
No abstract text is available yet for this article.
February 28, 2017: Thorax
https://www.readbyqxmd.com/read/28246220/validation-of-a-health-related-quality-of-life-instrument-for-primary-ciliary-dyskinesia-qol-pcd
#15
Laura Behan, Margaret W Leigh, Sharon D Dell, Audrey Dunn Galvin, Alexandra L Quittner, Jane S Lucas
BACKGROUND: Quality of life (QOL)-primary ciliary dyskinesia (PCD) is the first disease-specific, health-related QOL instrument for PCD. Psychometric validation of QOL-PCD assesses the performance of this measure in adults, including its reliability, validity and responsiveness to change. METHODS: Seventy-two adults (mean (range) age: 33 years (18-79 years); mean (range) FEV1% predicted: 68 (26-115)) with PCD completed the 49-item QOL-PCD and generic QOL measures: Short-Form 36 Health Survey, Sino-Nasal Outcome Test 20 (SNOT-20) and St George Respiratory Questionnaire (SGRQ)-C...
February 28, 2017: Thorax
https://www.readbyqxmd.com/read/28242750/role-of-interleukin-33-in-chronic-rhinosinusitis
#16
EDITORIAL
Roma Sehmi
No abstract text is available yet for this article.
February 27, 2017: Thorax
https://www.readbyqxmd.com/read/28235887/the-interaction-between-bronchoconstriction-and-cough-in-asthma
#17
LETTER
Imran Satia, Huda Badri, Mark Woodhead, Paul M O'Byrne, Stephen J Fowler, Jaclyn A Smith
Variable airflow obstruction is a pathophysiological hallmark of asthma; however, the interactions between acute bronchoconstriction and the cough reflex are poorly understood. We performed a randomised, single-blind, placebo-controlled, crossover study to investigate the interaction between bronchoconstriction and cough in asthma. Capsaicin was administered to evoke coughs and methacholine to induce bronchoconstriction. We demonstrated that acute bronchoconstriction increased capsaicin-evoked coughs, which improved as airway calibre spontaneously resolved...
February 24, 2017: Thorax
https://www.readbyqxmd.com/read/28235886/the-pearl-score-predicts-90-day-readmission-or-death-after-hospitalisation-for-acute-exacerbation-of-copd
#18
C Echevarria, J Steer, K Heslop-Marshall, S C Stenton, P M Hickey, R Hughes, M Wijesinghe, R N Harrison, N Steen, A J Simpson, G J Gibson, S C Bourke
BACKGROUND: One in three patients hospitalised due to acute exacerbation of COPD (AECOPD) is readmitted within 90 days. No tool has been developed specifically in this population to predict readmission or death. Clinicians are unable to identify patients at particular risk, yet resources to prevent readmission are allocated based on clinical judgement. METHODS: In participating hospitals, consecutive admissions of patients with AECOPD were identified by screening wards and reviewing coding records...
February 24, 2017: Thorax
https://www.readbyqxmd.com/read/28232509/let-air-out-of-the-bowel-to-allow-more-air-in-the-lungs-surgical-treatment-of-weaning-failure
#19
Hugh Ip, Wen Ling Woo, Amir Darakhshan, Nicholas Hart
No abstract text is available yet for this article.
February 23, 2017: Thorax
https://www.readbyqxmd.com/read/28232508/pulmonary-hypertension-in-ards-inflammation-matters
#20
EDITORIAL
Laura C Price, S John Wort
No abstract text is available yet for this article.
February 23, 2017: Thorax
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