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Thorax

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https://www.readbyqxmd.com/read/28232509/let-air-out-of-the-bowel-to-allow-more-air-in-the-lungs-surgical-treatment-of-weaning-failure
#1
Hugh Ip, Wen Ling Woo, Amir Darakhshan, Nicholas Hart
No abstract text is available yet for this article.
February 23, 2017: Thorax
https://www.readbyqxmd.com/read/28232508/pulmonary-hypertension-in-ards-inflammation-matters
#2
EDITORIAL
Laura C Price, S John Wort
No abstract text is available yet for this article.
February 23, 2017: Thorax
https://www.readbyqxmd.com/read/28228487/could-a-healthy-diet-attenuate-copd-risk-in-smokers
#3
EDITORIAL
Raphaëlle Varraso, Seif O Shaheen
No abstract text is available yet for this article.
February 22, 2017: Thorax
https://www.readbyqxmd.com/read/28228486/fruit-and-vegetable-consumption-and-risk-of-copd-a-prospective-cohort-study-of-men
#4
Joanna Kaluza, Susanna C Larsson, Nicola Orsini, Anders Linden, Alicja Wolk
BACKGROUND: Antioxidants present in fruits and vegetables may protect the lung from oxidative damage and prevent COPD. AIMS: To determine the association between fruit and vegetable consumption and risk of COPD by smoking status in men. METHODS: The population-based prospective Cohort of Swedish Men included 44 335 men, aged 45-79 years, with no history of COPD at baseline. Fruit and vegetable consumption was assessed with a self-administered questionnaire...
February 22, 2017: Thorax
https://www.readbyqxmd.com/read/28219955/implementation-of-the-needs-assessment-tool-for-patients-with-interstitial-lung-disease-nat-ild-facilitators-and-barriers
#5
LETTER
C Reigada, A Papadopoulos, J W Boland, J Yorke, J Ross, D C Currow, S Hart, S Bajwah, G Grande, A Wells, M J Johnson
A Needs Assessment Tool (NAT) was developed previously to help clinicians identify the supportive/palliative needs of people with interstitial lung disease (ILD) (NAT:ILD). This letter presents barriers and facilitators to clinical implementation. Data from (1) a focus group of respiratory clinicians and (2) an expert consensus group (respiratory and palliative clinicians, academics, patients, carers) were analysed using Framework Analysis. Barriers related to resources and service reconfiguration, and facilitators to clinical need, structure, objectiveness, flexibility and benefits of an 'aide-memoire'...
February 20, 2017: Thorax
https://www.readbyqxmd.com/read/28213592/the-evidence-of-benefits-of-exercise-training-in-interstitial-lung-disease-a-randomised-controlled-trial
#6
Leona M Dowman, Christine F McDonald, Catherine J Hill, Annemarie L Lee, Kathryn Barker, Claire Boote, Ian Glaspole, Nicole S L Goh, Anne M Southcott, Angela T Burge, Rebecca Gillies, Alicia Martin, Anne E Holland
BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs). OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity. METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care...
February 17, 2017: Thorax
https://www.readbyqxmd.com/read/28213591/peer-support-to-improve-recovery-following-critical-care-discharge-a-case-based-discussion
#7
Joanne McPeake, Theodore J Iwashyna, Helen Devine, Pamela MacTavish, Tara Quasim
No abstract text is available yet for this article.
February 17, 2017: Thorax
https://www.readbyqxmd.com/read/28209653/multidrug-resistant-tb-in-eastern-region-of-the-eu-is-the-shorter-regimen-an-exception-or-a-rule
#8
LETTER
Yanina Balabanova, Lena Fiebig, Olga Ignatyeva, Vija Riekstina, Manfred Danilovits, Kaadri Jaama, Edita Davidaviciene, Birute Radiulyte, Christina Marcela Popa, Vladyslav Nikolayevskyy, Francis Drobniewski
WHO recently recommended the use of a shorter multidrug-resistant TB (MDR-TB) regimen under programmatic conditions. We assessed eligibility for this regimen in a cohort of 737 adult patients with MDR-TB from Latvia, Lithuania, Estonia and Bucharest city recruited in 2007 and 2009. Only 4.2% of the patients were eligible for this regimen. Ethambutol (64%), pyrazinamide resistance (58%) and previous exposure to second-line TB drugs were major reasons for non-eligibility. High-level resistance to isoniazid is expected due to widespread prevalence of katG mutations...
February 16, 2017: Thorax
https://www.readbyqxmd.com/read/28202627/tumour-associated-neutrophils-and-loss-of-epithelial-pten-can-promote-corticosteroid-insensitive-mmp-9-expression-in-the-chronically-inflamed-lung-microenvironment
#9
LETTER
Amanda Vannitamby, Huei Jiunn Seow, Gary Anderson, Ross Vlahos, Michelle Thompson, Daniel Steinfort, Louis B Irving, Steven Bozinovski
Matrix metalloproteinase-9 (MMP-9) is increased in a number of pathological lung conditions, where the proteinase contributes to deleterious remodelling of the airways. While both lung cancer and COPD are associated with increased MMP-9 expression, the cellular and molecular drivers of MMP-9 remain unresolved. In this study, MMP-9 transcript measured within the tumour region from patients with non-small-cell lung cancer (NSCLC) and coexisting COPD was found to be uniformly increased relative to adjacent tumour-free tissue...
February 15, 2017: Thorax
https://www.readbyqxmd.com/read/28196900/turning-a-challenge-into-an-opportunity-pulmonary-rehabilitation-and-socioeconomic-deprivation
#10
EDITORIAL
Kylie N Johnston, Marie T Williams
No abstract text is available yet for this article.
February 14, 2017: Thorax
https://www.readbyqxmd.com/read/28183790/beyond-mortality-or-being-mortal-challenges-in-understanding-and-improving-life-after-ards
#11
EDITORIAL
Catherine L Hough
No abstract text is available yet for this article.
February 9, 2017: Thorax
https://www.readbyqxmd.com/read/28174341/pulmonary-artery-aneurysms-and-thrombi
#12
C M J Steendam, A L Diederik, A Dendooven, R J Snijder, G J Herder
No abstract text is available yet for this article.
February 7, 2017: Thorax
https://www.readbyqxmd.com/read/28174340/genetic-variants-affecting-cross-sectional-lung-function-in-adults-show-little-or-no-effect-on-longitudinal-lung-function-decline
#13
Catherine John, María Soler Artigas, Jennie Hui, Sune Fallgaard Nielsen, Nicholas Rafaels, Peter D Paré, Nadia N Hansel, Nick Shrine, Iain Kilty, Anders Malarstig, Scott A Jelinsky, Signe Vedel-Krogh, Kathleen Barnes, Ian P Hall, John Beilby, Arthur W Musk, Børge G Nordestgaard, Alan James, Louise V Wain, Martin D Tobin
BACKGROUND: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined. OBJECTIVES: We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek novel variants which influence decline. METHODS: We analysed genome-wide data from 4167 individuals from the Busselton Health Study cohort, who had undergone spirometry (12 695 observations across eight time points)...
February 7, 2017: Thorax
https://www.readbyqxmd.com/read/28159773/corticosteroids-and-infliximab-impair-the-performance-of-interferon-%C3%AE-release-assays-used-for-diagnosis-of-latent-tuberculosis
#14
LETTER
Alexander Edwards, Yifang Gao, Raymond N Allan, Darran Ball, Hans de Graaf, Tracy Coelho, Vanessa Clifford, Nigel Curtis, Anthony Williams, Saul N Faust, Salah Mansour, Ben Marshall, Paul Elkington, Marc Tebruegge
The impact of immunosuppression on interferon-γ release assays and novel cytokine biomarkers of TB infection, mycobacteria-specific IL-2, IP-10 and TNF-α responses was investigated in an ex vivo model. Cytokine responses in standard QuantiFERON-TB Gold in-Tube (QFT-GIT) assays were compared with duplicate assays containing dexamethasone or infliximab. Dexamethasone converted QFT-GIT results from positive to negative in 30% of participants. Antigen-stimulated interferon-γ, IL-2 and TNF-α responses were markedly reduced, but IP-10 responses were preserved...
February 3, 2017: Thorax
https://www.readbyqxmd.com/read/28159772/%C3%AE-tocopherol-transfer-protein-mediates-protective-hypercapnia-in-murine-ventilator-induced-lung-injury
#15
Gail Otulakowski, Doreen Engelberts, Hajime Arima, Hiroyuki Hirate, Hülya Bayir, Martin Post, Brian P Kavanagh
RATIONALE: Hypercapnia is common in mechanically ventilated patients. Experimentally, 'therapeutic hypercapnia' can protect, but it can also cause harm, depending on the mechanism of injury. Hypercapnia suppresses multiple signalling pathways. Previous investigations have examined mechanisms that were known a priori, but only a limited number of pathways, each suppressed by CO2, have been reported. OBJECTIVE: Because of the complexity and interdependence of processes in acute lung injury, this study sought to fill in knowledge gaps using an unbiased screen, aiming to identify a specifically upregulated pathway...
February 3, 2017: Thorax
https://www.readbyqxmd.com/read/28151399/giant-thymic-cyst-mimicking-a-unilateral-pleural-effusion
#16
Anita Nguyen, Hameed Habib, Wael I Awad
No abstract text is available yet for this article.
February 1, 2017: Thorax
https://www.readbyqxmd.com/read/28143893/giant-pulmonary-hydatid-cyst
#17
Chenglin Guo, Qiang Pu, Jiandong Mei, Lunxu Liu
No abstract text is available yet for this article.
January 31, 2017: Thorax
https://www.readbyqxmd.com/read/28137919/secondary-care-costs-associated-with-lung-cancer-diagnosed-at-emergency-hospitalisation-in-the-united-kingdom
#18
LETTER
Martyn P T Kennedy, Peter S Hall, Matthew E J Callister
Lung cancer diagnosis during emergency hospital admission has been associated with higher early secondary-care costs and lower longer-term costs than outpatient diagnoses. This retrospective cohort study analyses the secondary-care costs of 3274 consecutive patients with lung cancer. Patients diagnosed during emergency admissions incurred greater costs during the first month and had a worse prognosis compared with outpatient diagnoses. In patients who remained alive, costs after the first month were comparable between diagnostic routes...
January 30, 2017: Thorax
https://www.readbyqxmd.com/read/28137918/physical-activity-is-increased-by-a-12-week-semiautomated-telecoaching-programme-in-patients-with-copd-a-multicentre-randomised-controlled-trial
#19
H Demeyer, Z Louvaris, A Frei, R A Rabinovich, C de Jong, E Gimeno-Santos, M Loeckx, S C Buttery, N Rubio, T Van der Molen, N S Hopkinson, I Vogiatzis, M A Puhan, J Garcia-Aymerich, M I Polkey, T Troosters
RATIONALE: Reduced physical activity (PA) in patients with COPD is associated with a poor prognosis. Increasing PA is a key therapeutic target, but thus far few strategies have been found effective in this patient group. OBJECTIVES: To investigate the effectiveness of a 12-week semiautomated telecoaching intervention on PA in patients with COPD in a multicentre European randomised controlled trial. METHODS: 343 patients from six centres, encompassing a wide spectrum of disease severity, were randomly allocated to either a usual care group (UCG) or a telecoaching intervention group (IG) between June and December 2014...
January 30, 2017: Thorax
https://www.readbyqxmd.com/read/28130492/cpap-or-non-invasive-ventilation-in-obesity-hypoventilation-syndrome-does-it-matter-which-one-you-start-with
#20
EDITORIAL
Julio R Noda, Juan F Masa, Babak Mokhlesi
No abstract text is available yet for this article.
January 27, 2017: Thorax
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