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Jose Rojas-Camayo, Christian Richard Mejia, David Callacondo, Jennifer A Dawson, Margarita Posso, Cesar Alberto Galvan, Nadia Davila-Arango, Erick Anibal Bravo, Viky Yanina Loescher, Magaly Milagros Padilla-Deza, Nora Rojas-Valero, Gary Velasquez-Chavez, Jose Clemente, Guisela Alva-Lozada, Angel Quispe-Mauricio, Silvana Bardalez, Rami Subhi
Oxygen saturation, measured by pulse oximetry (SpO2), is a vital clinical measure. Our descriptive, cross-sectional study describes SpO2 measurements from 6289 healthy subjects from age 1 to 80 years at 15 locations from sea level up to the highest permanent human habitation. Oxygen saturation measurements are illustrated as percentiles. As altitude increased, SpO2 decreased, especially at altitudes above 2500 m. The increase in altitude had a significant impact on SpO2 measurements for all age groups. Our data provide a reference range for expected SpO2 measurements in people from 1 to 80 years from sea level to the highest city in the world...
October 20, 2017: Thorax
Minal S Kale, Keith Sigel, Grace Mhango, Juan P Wisnivesky
BACKGROUND: Overdiagnosis among clinically detected lung cancers likely consists of cases that are non-aggressive and slowly progressive and will never disseminate, cause symptoms or be a threat to a subject's survival, even if untreated. In this study, we estimate the prevalence of non-aggressive lung cancers from a large, population-based cancer registry. METHODS: We identified individuals ≥65 years with histologically confirmed, untreated stage I non-small cell lung cancers (NSCLCs) from the Surveillance, Epidemiology, and End Results-Medicare registry...
October 20, 2017: Thorax
Gerrard Phillips
No abstract text is available yet for this article.
October 17, 2017: Thorax
Satyajeet Sahoo, Manoj Kumar Panigrahi, Sourin Bhuniya, Prasanta Raghab Mohapatra
No abstract text is available yet for this article.
October 13, 2017: Thorax
Thomas Hewson, Tricia M McKeever, Jack E Gibson, Vidya Navaratnam, Richard B Hubbard, John P Hutchinson
Little is known about when symptoms of idiopathic pulmonary fibrosis first develop. We identified incident cases of idiopathic pulmonary fibrosis-clinical syndrome (IPF-CS) from a UK primary care database and assessed the frequency of consultations for common symptoms in the 5 years prior to diagnosis. 1671 cases were identified with 5 years of data prior to diagnosis. Breathlessness was the most common symptom, followed by cough. Cases were significantly more likely than controls to experience these symptoms (p<0...
October 11, 2017: Thorax
Tim Rosenow
No abstract text is available yet for this article.
October 9, 2017: Thorax
Janet Bee, Sharon Fuller, Suzanne Miller, Simon R Johnson
RATIONALE: Mechanistic target of rapamycin inhibitors reduce loss of lung function in lymphangioleiomyomatosis (LAM), although their benefit varies between individuals. We examined lung function response and side effects to rapamycin in a national cohort. METHODS: Subjects were receiving rapamycin for progressive lung disease. Clinical evaluation, detailed phenotyping, serial lung function, rapamycin and safety monitoring were performed according to a clinical protocol...
October 9, 2017: Thorax
Maria Tsakok, Dinesh Addala, Clare Bradley, Alistair Moore, Fergus Gleeson
No abstract text is available yet for this article.
October 9, 2017: Thorax
Luca Richeldi, Michael Kreuter, Moisés Selman, Bruno Crestani, Anne-Marie Kirsten, Wim A Wuyts, Zuojun Xu, Katell Bernois, Susanne Stowasser, Manuel Quaresma, Ulrich Costabel
The TOMORROW trial of nintedanib comprised a randomised, placebo-controlled, 52-week period followed by a further blinded treatment period and an open-label extension. We assessed outcomes across these periods in patients randomised to nintedanib 150 mg twice daily or placebo at the start of TOMORROW. The annual rate of decline in FVC was -125.4 mL/year (95% CI -168.1 to -82.7) in the nintedanib group and -189.7 mL/year (95% CI -229.8 to -149.6) in the comparator group. The adverse event profile of nintedanib remained consistent throughout the studies...
October 9, 2017: Thorax
Nicola Latronico, Cosetta Minelli, Matthias Eikermann
No abstract text is available yet for this article.
October 7, 2017: Thorax
Omar Okasha, Hanna Rinta-Kokko, Arto A Palmu, Esa Ruokokoski, Jukka Jokinen, J Pekka Nuorti
INTRODUCTION: Limited data are available on population-level herd effects of infant 10-valent pneumococcal conjugate vaccine (PCV10) programmes on pneumonia. We assessed national trends in pneumococcal and all-cause pneumonia hospitalisations in adults aged ≥18 years, before and after infant PCV10 introduction in 2010. METHODS: Monthly hospitalisation rates of International Statistical Classification of Diseases, 10th revision (ICD-10)-coded primary discharge diagnoses compatible with pneumonia from 2004-2005 to 2014-2015 were calculated with population denominators from the population register...
October 7, 2017: Thorax
Konrad E Bloch, Fabienne Huber, Michael Furian, Tsogyal D Latshang, Christian M Lo Cascio, Yvonne Nussbaumer-Ochsner, Oliver Senn, Erich W Russi, Malcolm Kohler, Otto D Schoch, Alexander Turk, Edelbert Imhof, Irène Laube, Felix Matthews, Robert Thurnheer
BACKGROUND: The obstructive sleep apnoea syndrome (OSAS) is conventionally treated by continuous positive airway pressure set at a fixed level (fCPAP). Automatic mask pressure adjustment (autoCPAP) is increasingly used during home therapy. We investigated whether autoCPAP is equivalent to fCPAP in improving sleepiness in patients with OSAS in the long-term. METHODS: In this multicentre equivalence trial, 208 patients with OSAS, with median Epworth sleepiness score (ESS) 13, apnoea/hypopnoea index 48...
October 5, 2017: Thorax
Asli Kalin, Maged Hassan, Mark Anderson, Najib Rahman
No abstract text is available yet for this article.
October 5, 2017: Thorax
Debbie Jarvis, Roger Newson, Christer Janson, Angelo Corsico, Joachim Heinrich, Josep M Anto, Michael J Abramson, Anne-Marie Kirsten, Jan Paul Zock, Roberto Bono, Pascal Demoly, Bénédicte Leynaert, Chantal Raherison, Isabelle Pin, Thorarinn Gislason, Rain Jogi, Vivi Schlunssen, Cecilie Svanes, John Watkins, Joost Weyler, Antonio Pereira-Vega, Isabel Urrutia, Jose A Gullón, Bertil Forsberg, Nicole Probst-Hensch, H Marike Boezen, Jesús Martinez-Moratalla Rovira, Simone Accordini, Roberto de Marco, Peter Burney
BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy. METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates...
October 3, 2017: Thorax
Swapna Mandal, Eui-Sik Suh, Rachel Harding, Anna Vaughan-France, Michelle Ramsay, Bronwen Connolly, Danielle E Bear, Helen MacLaughlin, Sharlene A Greenwood, Michael I Polkey, Mark Elliott, Tao Chen, Abdel Douiri, John Moxham, Patrick B Murphy, Nicholas Hart
BACKGROUND: Respiratory management of obesity hypoventilation syndrome (OHS) focusses on the control of sleep-disordered breathing rather than the treatment of obesity. Currently, there are no data from randomised trials of weight loss targeted rehabilitation programmes for patients with OHS. INTERVENTION: A 3-month multimodal hybrid inpatient-outpatient motivation, exercise and nutrition rehabilitation programme, in addition to non invasive ventilation (NIV), would result in greater per cent weight loss compared with standard care...
September 29, 2017: Thorax
Luis Puente-Maestu, Walther Ivan Girón-Matute
No abstract text is available yet for this article.
September 29, 2017: Thorax
Nick A Maskell
No abstract text is available yet for this article.
September 25, 2017: Thorax
Kenny Schlosser, Mohamad Taha, Yupu Deng, Lauralyn A McIntyre, Shirley H J Mei, Duncan J Stewart
BACKGROUND: Elevated plasma levels of angiopoietin-2 (ANGPT2) have been reported in patients with acute lung injury (ALI); however, it remains unclear whether this increase contributes to, or just marks, the underlying vasculopathic inflammation and leak associated with ALI. Here we investigated the biological consequences of inducing high circulating levels of ANGPT2 in a mouse model of endotoxin-induced ALI. METHODS: Transgenic mice (ANGPT2(OVR)) with elevated circulating levels of ANGPT2, achieved through conditional hepatocyte-specific overexpression, were examined from 3 to 72 hours following lipopolysaccharide (LPS)-induced ALI...
September 25, 2017: Thorax
Jorge Blázquez-Prieto, Inés López-Alonso, Laura Amado-Rodríguez, Covadonga Huidobro, Adrián González-López, Wolfgang M Kuebler, Guillermo M Albaiceta
BACKGROUND: Neutrophils may cause tissue disruption during migration and by releasing cytotoxic molecules. However, the benefits of neutrophil depletion observed in experimental models of lung injury do not correspond with the poor outcome of neutropenic patients. METHODS: To clarify the role of neutrophils during repair, mice with ventilator induced lung injury (VILI) were rendered neutropenic after damage, and followed for 48 hours of spontaneous breathing. Lungs were harvested and inflammatory mediators and matrix metalloproteinases measured...
September 25, 2017: Thorax
Andrey V Zinchuk, Sangchoon Jeon, Brian B Koo, Xiting Yan, Dawn M Bravata, Li Qin, Bernardo J Selim, Kingman P Strohl, Nancy S Redeker, John Concato, Henry K Yaggi
BACKGROUND: Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved understanding of physiologic phenotypes and their clinical implications is needed. We aimed to determine whether routine polysomnographic data can be used to identify OSA phenotypes (clusters) and to assess the associations between the phenotypes and cardiovascular outcomes. METHODS: Cross-sectional and longitudinal analyses of a multisite, observational US Veteran (n=1247) cohort were performed...
September 21, 2017: Thorax
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