journal
MENU ▼
Read by QxMD icon Read
search

Thorax

journal
https://www.readbyqxmd.com/read/28802279/rare-adult-presentation-of-fixed-airways-obstruction-remember-aortic-arch-abnormalities
#1
Juwhan Choi, Kyung Hoon Min, Sung Yong Lee, Kyung Ho Kang, Jae Jeong Shim
No abstract text is available yet for this article.
August 11, 2017: Thorax
https://www.readbyqxmd.com/read/28802278/gdf11-a-fountain-of-youth-for-the-ageing-copd-lung
#2
EDITORIAL
Ma'en Obeidat, Don D Sin
No abstract text is available yet for this article.
August 11, 2017: Thorax
https://www.readbyqxmd.com/read/28802277/microbiome-in-lung-explants-of-idiopathic-pulmonary-fibrosis-a-case-control-study-in-patients-with-end-stage-fibrosis
#3
Georgios D Kitsios, Mauricio Rojas, Daniel J Kass, Adam Fitch, John C Sembrat, Shulin Qin, Kristen L Veraldi, Kevin F Gibson, Kathleen Lindell, Joseph M Pilewski, Barbara Methe, Kelvin Li, John McDyer, Bryan J McVerry, Alison Morris
The microbiome has been proposed to play a role in the progression of idiopathic pulmonary fibrosis (IPF) based on bronchoalveolar lavage analyses, but the microbiome of lung tissue in IPF has not been explored. In a case-control study of lung explants analysed by 16S rRNA gene sequencing, we could not reliably detect bacterial DNA in basilar tissue samples from patients with either chronic or acute exacerbations of IPF, in contrast to control candidate-donor lungs or cystic fibrosis explants. Thus, our data do not indicate microbiome alterations in regions of IPF lung with advanced fibrosis...
August 11, 2017: Thorax
https://www.readbyqxmd.com/read/28798214/role-of-atmospheric-pollution-on-the-natural-history-of-idiopathic-pulmonary-fibrosis
#4
Lucile Sesé, Hilario Nunes, Vincent Cottin, Shreosi Sanyal, Morgane Didier, Zohra Carton, Dominique Israel-Biet, Bruno Crestani, Jacques Cadranel, Benoit Wallaert, Abdellatif Tazi, Bernard Maître, Grégoire Prévot, Sylvain Marchand-Adam, Stéphanie Guillot-Dudoret, Annelyse Nardi, Sandra Dury, Violaine Giraud, Anne Gondouin, Karine Juvin, Raphael Borie, Marie Wislez, Dominique Valeyre, Isabella Annesi-Maesano
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) has an unpredictable course corresponding to various profiles: stability, physiological disease progression and rapid decline. A minority of patients experience acute exacerbations (AEs). A recent study suggested that ozone and nitrogen dioxide might contribute to the occurrence of AE. We hypothesised that outdoor air pollution might influence the natural history of IPF. METHODS: Patients were selected from the French cohort COhorte FIbrose (COFI), a national multicentre longitudinal prospective cohort of IPF (n=192)...
August 10, 2017: Thorax
https://www.readbyqxmd.com/read/28790180/pseudomonas-aeruginosa-lasb-protease-impairs-innate-immunity-in-mice-and-humans-by-targeting-a-lung-epithelial-cystic-fibrosis-transmembrane-regulator-il-6-antimicrobial-repair-pathway
#5
Vinciane Saint-Criq, Bérengère Villeret, Fabien Bastaert, Saadé Kheir, Aurélie Hatton, Aurélie Cazes, Zhou Xing, Isabelle Sermet-Gaudelus, Ignacio Garcia-Verdugo, Aleksander Edelman, Jean-Michel Sallenave
BACKGROUND: Pseudomonas aeruginosa lung infections are a huge problem in ventilator-associated pneumonia, cystic fibrosis (CF) and in chronic obstructive pulmonary disease (COPD) exacerbations. This bacterium secretes virulence factors that may subvert host innate immunity. OBJECTIVE: We evaluated the effect of P. aeruginosa elastase LasB, an important virulence factor secreted by the type II secretion system, on ion transport, innate immune responses and epithelial repair, both in vitro and in vivo...
August 8, 2017: Thorax
https://www.readbyqxmd.com/read/28790179/high-prevalence-of-ccdc103-p-his154pro-mutation-causing-primary-ciliary-dyskinesia-disrupts-protein-oligomerisation-and-is-associated-with-normal-diagnostic-investigations
#6
Amelia Shoemark, Eduardo Moya, Robert A Hirst, Mitali P Patel, Evelyn A Robson, Jane Hayward, Juliet Scully, Mahmoud R Fassad, William Lamb, Miriam Schmidts, Mellisa Dixon, Ramila S Patel-King, Andrew V Rogers, Andrew Rutman, Claire L Jackson, Patricia Goggin, Bruna Rubbo, Sarah Ollosson, Siobhán Carr, Woolf Walker, Beryl Adler, Michael R Loebinger, Robert Wilson, Andrew Bush, Hywel Williams, Christopher Boustred, Lucy Jenkins, Eamonn Sheridan, Eddie M K Chung, Christopher M Watson, Thomas Cullup, Jane S Lucas, Priti Kenia, Christopher O'Callaghan, Stephen M King, Claire Hogg, Hannah M Mitchison
RATIONALE: Primary ciliary dyskinesia is a genetically heterogeneous inherited condition characterised by progressive lung disease arising from abnormal cilia function. Approximately half of patients have situs inversus. The estimated prevalence of primary ciliary dyskinesia in the UK South Asian population is 1:2265. Early, accurate diagnosis is key to implementing appropriate management but clinical diagnostic tests can be equivocal. OBJECTIVES: To determine the importance of genetic screening for primary ciliary dyskinesia in a UK South Asian population with a typical clinical phenotype, where standard testing is inconclusive...
August 8, 2017: Thorax
https://www.readbyqxmd.com/read/28780505/local-dornase-alfa-treatment-reduces-nets-induced-airway-obstruction-during-severe-rsv-infection
#7
Bart Cortjens, Rineke de Jong, Judith G Bonsing, Job B M van Woensel, Adriaan F G Antonis, Reinout A Bem
Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction. Viral load in the lower respiratory tract was not different between the two groups...
August 5, 2017: Thorax
https://www.readbyqxmd.com/read/28780504/intensive-versus-standard-physical-rehabilitation-therapy-in-the-critically-ill-epicc-a-multicentre-parallel-group-randomised-controlled-trial
#8
Stephen E Wright, Kirsty Thomas, Gillian Watson, Catherine Baker, Andrew Bryant, Thomas J Chadwick, Jing Shen, Ruth Wood, Jennifer Wilkinson, Leigh Mansfield, Victoria Stafford, Clare Wade, Julie Furneval, Andrea Henderson, Keith Hugill, Philip Howard, Alistair Roy, Stephen Bonner, Simon Baudouin
BACKGROUND: Early physical rehabilitation in the intensive care unit (ICU) has been shown to improve short-term clinical outcomes but long-term benefit has not been proven and the optimum intensity of rehabilitation is not known. METHODS: We conducted a randomised, parallel-group, allocation-concealed, assessor-blinded, controlled trial in patients who had received at least 48 hours of invasive or non-invasive ventilation. Participants were randomised in a 1:1 ratio, stratified by admitting ICU, admission type and level of independence...
August 5, 2017: Thorax
https://www.readbyqxmd.com/read/28780503/late-mortality-after-acute-hypoxic-respiratory-failure
#9
Hallie C Prescott, Michael W Sjoding, Kenneth M Langa, Theodore J Iwashyna, Daniel F McAuley
BACKGROUND: Acute hypoxic respiratory failure (AHRF) is associated with significant acute mortality. It is unclear whether later mortality is predominantly driven by pre-existing comorbid disease, the acute inciting event or is the result of AHRF itself. METHODS: Observational cohort study of elderly US Health and Retirement Study (HRS) participants in fee-for-service Medicare (1998-2012). Patients hospitalised with AHRF were matched 1:1 to otherwise similar adults who were not currently hospitalised and separately to patients hospitalised with acute inciting events (pneumonia, non-pulmonary infection, aspiration, trauma, pancreatitis) that may result in AHRF, here termed at-risk hospitalisations...
August 5, 2017: Thorax
https://www.readbyqxmd.com/read/28780502/pulmonary-ccr2-cd4-t-cells-are-immune-regulatory-and-attenuate-lung-fibrosis-development
#10
Katrin Milger, Yingyan Yu, Eva Brudy, Martin Irmler, Alla Skapenko, Michael Mayinger, Mareike Lehmann, Johannes Beckers, Frank Reichenberger, Jürgen Behr, Oliver Eickelberg, Melanie Königshoff, Susanne Krauss-Etschmann
BACKGROUND: Animal models have suggested that CCR2-dependent signalling contributes to the pathogenesis of pulmonary fibrosis, but global blockade of CCL2 failed to improve the clinical course of patients with lung fibrosis. However, as levels of CCR2(+)CD4(+) T cells in paediatric lung fibrosis had previously been found to be increased, correlating with clinical symptoms, we hypothesised that distinct CCR2(+) cell populations might either increase or decrease disease pathogenesis depending on their subtype...
August 5, 2017: Thorax
https://www.readbyqxmd.com/read/28778921/respiratory-viruses-in-healthy-infants-and-infants-with-cystic-fibrosis-a-prospective-cohort-study
#11
Insa Korten, Elisabeth Kieninger, Shkipe Klenja, Ines Mack, Njima Schläpfer, Maria Teresa Barbani, Nicolas Regamey, Claudia E Kuehni, Markus Hilty, Urs Frey, Meri Gorgievski, Carmen Casaulta, Philipp Latzin
RATIONALE: Acute viral respiratory tract infections in children with cystic fibrosis (CF) are known causes of disease exacerbation. The role of viral infections during infancy is, however, less known, although early infancy is thought to be a crucial period for CF disease development.We prospectively assessed symptomatic and asymptomatic viral detection in the first year of life in infants with CF and healthy controls. METHODS: In a prospective cohort study, we included 31 infants with CF from the Swiss Cystic Fibrosis Infant Lung Development Cohort and 32 unselected, healthy infants from the Basel Bern Infant Lung Development Cohort and followed them throughout the first year of life...
August 4, 2017: Thorax
https://www.readbyqxmd.com/read/28778920/understanding-patient-outcomes-after-acute-respiratory-distress-syndrome-identifying-subtypes-of-physical-cognitive-and-mental-health-outcomes
#12
Samuel M Brown, Emily L Wilson, Angela P Presson, Victor D Dinglas, Tom Greene, Ramona O Hopkins, Dale M Needham
PURPOSE: With improving short-term mortality in acute respiratory distress syndrome (ARDS), understanding survivors' posthospitalisation outcomes is increasingly important. However, little is known regarding associations among physical, cognitive and mental health outcomes. Identification of outcome subtypes may advance understanding of post-ARDS morbidities. METHODS: We analysed baseline variables and 6-month health status for participants in the ARDS Network Long-Term Outcomes Study...
August 4, 2017: Thorax
https://www.readbyqxmd.com/read/28778919/the-top-10-research-priorities-in-cystic-fibrosis-developed-by-a-partnership-between-people-with-cf-and-healthcare-providers
#13
Nicola J Rowbotham, Sherie Smith, Paul A Leighton, Oli C Rayner, Katie Gathercole, Zoe C Elliott, Edward F Nash, Tracey Daniels, Alistair J A Duff, Sarah Collins, Suja Chandran, Ursula Peaple, Matthew N Hurley, Keith Brownlee, Alan R Smyth
There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Research questions were elicited and then prioritised in successive surveys. A workshop agreed the final top 10. Online methods avoided cross infection and widened participation. The elicitation survey had 482 respondents (1080 questions) and prioritisation survey 677 respondents...
August 4, 2017: Thorax
https://www.readbyqxmd.com/read/28778918/comorbidities-mortality-and-causes-of-death-among-patients-with-tuberculosis-in-denmark-1998-2010-a-nationwide-register-based-case-control-study
#14
Andreas Fløe, Ole Hilberg, Christian Wejse, Rikke Ibsen, Anders Løkke
OBJECTIVE: To evaluate the impact of comorbidities, age and clinical presentation of TB on mortality among Danish patients with TB. METHODS: Danish patients with an ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th Revision) diagnosis of TB in 1998-2010 were identified in the National Patient Registry and matched with controls (1:4) on age, gender, civil status and geography. Comorbid diagnoses up to 3 years before and after TB diagnosis or enrolment as control as well as survival data were obtained from national databases RESULTS: We included 8433 cases and 33 707 controls...
August 4, 2017: Thorax
https://www.readbyqxmd.com/read/28765262/interplay-of-physiology-social-familial-and-behavioural-adaptation-in-the-long-term-outcome-of-ards
#15
EDITORIAL
Theodore J Iwashyna, Timothy S Walsh
No abstract text is available yet for this article.
August 1, 2017: Thorax
https://www.readbyqxmd.com/read/28756402/comparison-of-a-structured-home-based-rehabilitation-programme-with-conventional-supervised-pulmonary-rehabilitation-a-randomised-non-inferiority-trial
#16
Elizabeth J Horton, Katy E Mitchell, Vicki Johnson-Warrington, Lindsay D Apps, Louise Sewell, Mike Morgan, Rod S Taylor, Sally J Singh
BACKGROUND: Standardised home-based pulmonary rehabilitation (PR) programmes offer an alternative model to centre-based supervised PR for which uptake is currently poor. We determined if a structured home-based unsupervised PR programme was non-inferior to supervised centre-based PR for participants with COPD. METHODS: A total of 287 participants with COPD who were referred to PR (187 male, mean (SD) age 68 (8.86) years, FEV1% predicted 48.34 (17.92)) were recruited...
July 29, 2017: Thorax
https://www.readbyqxmd.com/read/28756401/double-whammy-the-disappearing-right-atrium
#17
Aparna Kadambi, Parimal Kumar Chaudhari, Lawrence DeLorenzo, Oleg Epelbaum
No abstract text is available yet for this article.
July 29, 2017: Thorax
https://www.readbyqxmd.com/read/28756400/perspectives-of-survivors-families-and-researchers-on-key-outcomes-for-research-in-acute-respiratory-failure
#18
Victor D Dinglas, Caroline M Chessare, Wesley E Davis, Ann Parker, Lisa Aronson Friedman, Elizabeth Colantuoni, Clifton O Bingham, Alison E Turnbull, Dale M Needham
BACKGROUND: There is heterogeneity among the outcomes evaluated in studies of survivors of acute respiratory failure (ARF). AIM: To evaluate the importance of specific outcome domains to acute respiratory distress syndrome (ARDS) survivors, their family members and clinical researchers. METHODS: Nineteen outcome domains were identified from the National Institutes of Health's Patient Reported Outcomes Measurement Information System; WHO's International Classification of Functioning, Disability, and Health; Society of Critical Care Medicine's Post-Intensive Care Syndrome (PICS); as well as patient, clinician and researcher input...
July 29, 2017: Thorax
https://www.readbyqxmd.com/read/28756399/lack-of-a-pulmonary-vein-causing-unilateral-interlobular-septal-thickening
#19
Hanping Wang, Li Zhang, Wei Liu, Kai-Feng Xu, Juhong Shi
No abstract text is available yet for this article.
July 29, 2017: Thorax
https://www.readbyqxmd.com/read/28747323/does-a-lung-cancer-screening-programme-promote-smoking-cessation
#20
EDITORIAL
Filippo Lococo, Giuseppe Cardillo, Giulia Veronesi
No abstract text is available yet for this article.
July 26, 2017: Thorax
journal
journal
20249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"