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Surgery

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https://www.readbyqxmd.com/read/28094003/recombinant-thrombomodulin-suppresses-tumor-growth-of-pancreatic-cancer-by-blocking-thrombin-induced-par1-and-nf-%C3%AE%C2%BAb-activation
#1
Yoshihiro Shirai, Tadashi Uwagawa, Hiroaki Shiba, Yohta Shimada, Takashi Horiuchi, Nobuhiro Saito, Kenei Furukawa, Toya Ohashi, Katsuhiko Yanaga
BACKGROUND: Thrombomodulin, an anticoagulant that inhibits thrombin-induced growth factor promotion, also has an anti-inflammatory effect. Furthermore, thrombomodulin inhibits nuclear factor-kappa B activation, which plays a crucial role in cancer progression. We assessed the antitumor activity of recombinant thrombomodulin for pancreatic cancer. METHODS: A xenograft orthotopic model was established in mice by implantation of human pancreatic cancer cells. The animals were treated with intraperitoneal injection of recombinant thrombomodulin 5 times a week for 4 weeks...
January 13, 2017: Surgery
https://www.readbyqxmd.com/read/28088323/vanishing-leg-ulcers
#2
Demetrios Moris, Vasileios Zavvos, Georgios Zavos
No abstract text is available yet for this article.
January 11, 2017: Surgery
https://www.readbyqxmd.com/read/28088322/failure-to-rescue-and-preventability-striving-for-the-impossible
#3
EDITORIAL
Angela M Ingraham, Caprice C Greenberg
No abstract text is available yet for this article.
January 11, 2017: Surgery
https://www.readbyqxmd.com/read/28088321/surgeon-pathologist-and-hospital-level-variation-in-suboptimal-lymph-node-examination-after-colectomy-compartmentalizing-quality-improvement-strategies
#4
Adan Z Becerra, Christopher T Aquina, Mariana Berho, Francis P Boscoe, Maria J Schymura, Katia Noyes, John R Monson, Fergal J Fleming
BACKGROUND: The goals of this study were to characterize the variation in suboptimal lymph node examination for patients with colon cancer across individual surgeons, pathologists, and hospitals and to examine if this variation affects 5-year, disease-specific survival. METHODS: A retrospective cohort study was conducted by merging the New York State Cancer Registry with the Statewide Planning & Research Cooperative System, Medicaid, and Medicare claims to identify resections for stages I-III colon cancer from 2004-2011...
January 11, 2017: Surgery
https://www.readbyqxmd.com/read/28087066/use-of-water-soluble-contrast-medium-gastrografin-does-not-decrease-the-need-for-operative-intervention-nor-the-duration-of-hospital-stay-in-uncomplicated-acute-adhesive-small-bowel-obstruction-a-multicenter-randomized-clinical-trial-adhesive-small-bowel-obstruction
#5
Michel Scotté, Francois Mauvais, Michael Bubenheim, Cyril Cossé, Leslie Suaud, Celine Savoye-Collet, Isabelle Plenier, Aurelien Péquignot, Thierry Yzet, Jean Marc Regimbeau
BACKGROUND: This study evaluated the association between oral gastrografin administration and the need for operative intervention in patients with presumed adhesive small bowel obstruction. METHODS: Between October 2006 and August 2009, 242 patients with uncomplicated acute adhesive small bowel obstruction were included in a randomized, controlled trial (the Adhesive Small Bowel Obstruction Study, NCT00389116) and allocated to a gastrografin arm or a saline solution arm...
January 10, 2017: Surgery
https://www.readbyqxmd.com/read/28081955/generation-of-patient-derived-xenografts-from-fine-needle-aspirates-or-core-needle-biopsy
#6
David Roife, Ya'an Kang, Li Wang, Bingliang Fang, Stephen G Swisher, Jeffrey E Gershenwald, Shanna Pretzsch, Colin P Dinney, Matthew H G Katz, Jason B Fleming
BACKGROUND: Patient-derived xenografts have recently become a powerful tool for cancer research and may be used to guide personalized therapy. Thus far, patient-derived xenografts have been grown from tumor tissue obtained after operative resection; however, many cancer patients never undergo operative intervention for a variety of reasons. We hypothesized that xenograft tumors could be grown from smaller volumes of patient tissue, such as those obtained during diagnostic biopsies. METHODS: Surgical specimens were obtained after resection of primary or metastatic lesions of the following cancers: pancreatic carcinoma, non-small cell lung cancer, bladder (urothelial) carcinoma, and melanoma...
January 9, 2017: Surgery
https://www.readbyqxmd.com/read/28081954/proton-beam-radiation-as-salvage-therapy-for-bilateral-colorectal-liver-metastases-not-amenable-to-second-stage-hepatectomy
#7
Lauren E Colbert, Jordan M Cloyd, Eugene J Koay, Christopher H Crane, Jean-Nicolas Vauthey
BACKGROUND: Bilobar colorectal liver metastases (CRLM), are now aggressively managed in a multidisciplinary fashion with a two-stage hepatectomy; however, up to 30% of patients are not candidates for second stage hepatectomy. In this report, we describe a novel technique of delivering ablative radiation to the entire right hemiliver by using proton therapy in a series of patients. METHODS: A data base of patients undergoing entire right hemiliver ablative radiation was maintained prospectively...
January 9, 2017: Surgery
https://www.readbyqxmd.com/read/28081953/neoadjuvant-chemotherapy-does-not-affect-future-liver-remnant-growth-and-outcomes-of-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy
#8
Kristina Hasselgren, Massimo Malagò, Soumil Vyas, Ricardo Robles Campos, Roberto Brusadin, Michael Linecker, Henrik Petrowsky, Pierre Alain Clavien, Marcel Autran Machado, Roberto Hernandez-Alejandro, Kerollos Wanis, Lars Valter, Per Sandström, Bergthor Björnsson
BACKGROUND: The only potentially curative treatment for patients with colorectal liver metastases is hepatectomy. Associating liver partition and portal vein ligation for staged hepatectomy has emerged as a method of treatment for patients with inadequate future liver remnant. One concern about associating liver partition and portal vein ligation for staged hepatectomy is that preoperative chemotherapy may negatively affect the volume increase of the future liver remnant and outcomes...
January 9, 2017: Surgery
https://www.readbyqxmd.com/read/28073588/overexpression-of-cytochrome-p450-2a6-in-adrenocortical-carcinoma
#9
Timothy D Murtha, Taylor C Brown, Jill C Rubinstein, Felix Haglund, C Christofer Juhlin, Catharina Larsson, Reju Korah, Tobias Carling
BACKGROUND: Cytochrome P450-mediated metabolism of chemotherapeutic agents contributes to chemotherapy resistance in multiple malignancies. Adrenocortical carcinoma is known to have a poor response to adjuvant therapies; however, the mechanism remains unknown. Recent comprehensive genetic analyses of adrenocortical carcinomas demonstrated recurrent copy number gains in multiple cytochrome P450 genes prompting investigation into whether cytochrome P450 overexpression potentiates adrenocortical carcinoma chemoresistance...
January 7, 2017: Surgery
https://www.readbyqxmd.com/read/28069263/use-of-robots-in-outpatient-operations-is-a-costly-proposition
#10
EDITORIAL
Steven D Schwaitzberg
No abstract text is available yet for this article.
January 6, 2017: Surgery
https://www.readbyqxmd.com/read/28063608/bile-and-sodium-trafficking-in-the-biliary-limb-after-roux-en-y-gastric-bypass
#11
LETTER
Camille Marciniak, Grégory Baud, Violeta Raverdy, Lorea Zubiaga, Mehdi Daoudi, Thomas Hubert, Robert Caiazzo, François Pattou
No abstract text is available yet for this article.
January 4, 2017: Surgery
https://www.readbyqxmd.com/read/28063607/do-great-teams-think-alike-an-examination-of-team-mental-models-and-their-impact-on%C3%A2-team%C3%A2-performance
#12
Aimee K Gardner, Daniel J Scott, Kareem R AbdelFattah
BACKGROUND: Team mental models represent the shared understanding of team members within their relevant environment. Thus, team mental models should have a substantial impact on a team's ability to engage in purposeful and coordinated action. We sought to examine the impact of shared team mental models on team performance and to investigate if team mental models increase over time as teams continue to work together. METHODS: New surgery interns were assigned randomly to 1 of 10 teams...
January 4, 2017: Surgery
https://www.readbyqxmd.com/read/28043695/standardizing-the-complication-rate-after-breast-reduction-using-the-clavien-dindo-classification
#13
Raimund Winter, Isabella Haug, Patricia Lebo, Martin Grohmann, Frederike M J Reischies, Janos Cambiaso-Daniel, Alexandru Tuca, Theresa Rienmüller, Herwig Friedl, Stephan Spendel, Abigail A Forbes, Paul Wurzer, Lars-P Kamolz
BACKGROUND: Published complication rates for breast reduction surgery, also known as reduction mammaplasty, vary between 4% and 54%. This wide range of complication rates could be attributable to the lack of a standardized classification of complications in plastic surgery. The aim of this study was to analyze our single-center complication rates after reduction mammaplasty using the Clavien-Dindo classification. METHODS: We performed a retrospective chart review studying 804 patients between the ages of 18 and 81 years old who underwent breast reduction between 2005 and 2015 at our institution...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28043694/operative-needs-in-hiv-populations-an-estimation-for-sub-saharan-africa
#14
Megan L Cherewick, Steven D Cherewick, Adam L Kushner
BACKGROUND: In 2015, it was estimated that approximately 36.7 million people were living with HIV globally and approximately 25.5 million of those people were living in sub-Saharan Africa. Limitations in the availability and access to adequate operative care require policy and planning to enhance operative capacity. METHODS: Data estimating the total number of persons living with HIV by country, sex, and age group were obtained from the Joint United Nations Programme on HIV/AIDS (UNAIDS) in 2015...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28043693/preoperative-biliary-stenting-versus-operation-first-in-jaundiced-patients-due-to-malignant-lesions-in-the-pancreatic-head-a-meta-analysis-of-current-literature
#15
REVIEW
Florian Scheufele, Stephan Schorn, Ihsan Ekin Demir, Mine Sargut, Elke Tieftrunk, Lenika Calavrezos, Carsten Jäger, Helmut Friess, Güralp Onur Ceyhan
BACKGROUND: Obstructive jaundice is a common presenting symptom among patients with pancreatic cancer. While benefits of preoperative biliary drainage have been suggested by previous studies, recent evidence has shown no significant improvements of preoperative biliary drainage on the postoperative outcome but rather an increase of complications. There is no clear consensus on whether to treat malignant obstructive jaundice with preoperative biliary drainage prior to operative intervention or to proceed directly to resection...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28043692/reply-to-papillary-thyroid-microcarcinoma-in-developing-country-scenario-with-endemic-iodine-deficiency
#16
LETTER
Jee Soo Kim
No abstract text is available yet for this article.
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28041743/iatrogenic-venous-air-embolism-from-central-venous-catheterization-after-blunt-liver-trauma
#17
Tarek Debs, Niccolo Petrucciani, Eric Sejor, Imed Ben Amor, Jean Gugenheim
No abstract text is available yet for this article.
December 29, 2016: Surgery
https://www.readbyqxmd.com/read/28041742/reply-to-electro-surgical-adjuncts-for-hemostasis-in-thyroidectomy
#18
LETTER
Miguel F Herrera
No abstract text is available yet for this article.
December 29, 2016: Surgery
https://www.readbyqxmd.com/read/28040257/the-2016-update-of-the-international-study-group-isgps-definition-and-grading-of-postoperative-pancreatic-fistula-11-years-after
#19
REVIEW
Claudio Bassi, Giovanni Marchegiani, Christos Dervenis, Micheal Sarr, Mohammad Abu Hilal, Mustapha Adham, Peter Allen, Roland Andersson, Horacio J Asbun, Marc G Besselink, Kevin Conlon, Marco Del Chiaro, Massimo Falconi, Laureano Fernandez-Cruz, Carlos Fernandez-Del Castillo, Abe Fingerhut, Helmut Friess, Dirk J Gouma, Thilo Hackert, Jakob Izbicki, Keith D Lillemoe, John P Neoptolemos, Attila Olah, Richard Schulick, Shailesh V Shrikhande, Tadahiro Takada, Kyoichi Takaori, William Traverso, Charles R Vollmer, Christopher L Wolfgang, Charles J Yeo, Roberto Salvia, Marcus Buchler
BACKGROUND: In 2005, the International Study Group of Pancreatic Fistula developed a definition and grading of postoperative pancreatic fistula that has been accepted universally. Eleven years later, because postoperative pancreatic fistula remains one of the most relevant and harmful complications of pancreatic operation, the International Study Group of Pancreatic Fistula classification has become the gold standard in defining postoperative pancreatic fistula in clinical practice. The aim of the present report is to verify the value of the International Study Group of Pancreatic Fistula definition and grading of postoperative pancreatic fistula and to update the International Study Group of Pancreatic Fistula classification in light of recent evidence that has emerged, as well as to address the lingering controversies about the original definition and grading of postoperative pancreatic fistula...
December 28, 2016: Surgery
https://www.readbyqxmd.com/read/28040256/moving-beyond-failure-to-rescue
#20
EDITORIAL
Melissa A Hornor, Karl Y Bilimoria
No abstract text is available yet for this article.
December 28, 2016: Surgery
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