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Surgery

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https://www.readbyqxmd.com/read/28222855/direct-growth-inhibitory-effects-of-prostaglandin-e2-in%C3%A2-pancreatic-cancer-cells-in%C3%A2-vitro-through-an-ep4-pka-mediated-mechanism
#1
Andrea Schmidt, James Sinnett-Smith, Steven Young, Hui-Hua Chang, O Joe Hines, David W Dawson, Enrique Rozengurt, Guido Eibl
BACKGROUND: There is strong evidence linking inflammation and the development of pancreatic ductal adenocarcinoma. Cyclooxygenase-2 (COX-2) and COX-2-derived PGE2 are overexpressed in human and murine pancreatic ductal adenocarcinoma. Several studies have demonstrated an important role of COX-2-derived PGE2 in tumor-stroma interactions; however, the direct growth effects of prostaglandin E2 (PGE2) on pancreatic ductal adenocarcinoma cells is less well defined. Our aim was to investigate the effects of PGE2 on pancreatic ductal adenocarcinoma cell growth and to characterize the underlying mechanisms...
February 17, 2017: Surgery
https://www.readbyqxmd.com/read/28222854/whatsapp-an-essential-m-health-tool-for-global-surgeons
#2
LETTER
Clifton Ewbank, Reinou S Groen, Adam L Kushner, Shailvi Gupta
No abstract text is available yet for this article.
February 17, 2017: Surgery
https://www.readbyqxmd.com/read/28222853/response-to-is-prehabilitation-limited-to-preoperative-exercise
#3
LETTER
Jonathan Moran, Emer Guinan, Paul McCormick, John Larkin, David Mockler, Juliette Hussey, Jeanne Moriarty, Fiona Wilson
No abstract text is available yet for this article.
February 17, 2017: Surgery
https://www.readbyqxmd.com/read/28202198/response-to-comment-on-live-tissue-versus-simulation-training-for-emergency-procedures-is-simulation-ready-to-replace-live-tissue
#4
LETTER
Stephen L Barnes, Jeffrey Kerby, John Armstrong, Luis Llerena, Alex Bukoski, Jay Anton
No abstract text is available yet for this article.
February 12, 2017: Surgery
https://www.readbyqxmd.com/read/28196605/comments-on-enucleation-a-treatment-alternative-for-branch-duct-intraductal-papillary-mucinous-neoplasms
#5
LETTER
Alain Sauvanet, Philippe Levy, Sébastien Gaujoux
No abstract text is available yet for this article.
February 10, 2017: Surgery
https://www.readbyqxmd.com/read/28187869/strength-of-verbs-in-medical-writing-should-correspond-to-the-level-of-evidence-or-degree-of-causality-a-plea-for-accuracy
#6
EDITORIAL
Abe Fingerhut, Michael G Sarr
No abstract text is available yet for this article.
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28187868/no-clinical-benefit-from-routine-histologic-examination-of-stapler-doughnuts-at-low-anterior-resection-for-rectal-cancer
#7
Jeremy Sugrue, Francois Dagbert, John Park, Slawomir Marecik, Leela M Prasad, Vivek Chaudhry, Jennifer Blumetti, Rajyasree Emmadi, Anders Mellgren, Johan Nordenstam
BACKGROUND: The aim of this study was to evaluate the clinical utility and cost-effectiveness of routine histologic examination of the doughnuts from stapled anastomoses in patients undergoing a low anterior resection for rectal cancer. METHODS: We performed a retrospective review of 486 patients who underwent a low anterior resection with stapled anastomosis for rectal cancer between 2002 and 2015 at 3 institutions. Pathologic findings in the doughnuts and their impact on patient management were recorded...
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28187867/clinicopathologic-study-on-metachronous-double-cholangiocarcinomas-of-perihilar-and-subsequent-distal-bile-duct-origin
#8
Kentaro Shinohara, Yoshie Shimoyama, Tomoki Ebata, Yukihiro Yokoyama, Takashi Mizuno, Masato Nakaguro, Masato Nagino
BACKGROUND: Despite an increasing number of long-term survivors after the resection of perihilar cholangiocarcinoma, metachronous carcinoma in the remnant distal bile duct has not been well documented because of its rarity. The aim of this study was to clarify the feasibility of operative resection and the pathologic features for metachronous double cholangiocarcinomas. METHODS: Between 2003 and 2013, 6 patients underwent resections for both a primary perihilar cholangiocarcinoma and a metachronous distal cholangiocarcinoma...
February 7, 2017: Surgery
https://www.readbyqxmd.com/read/28174000/the-michigan-surgical-home-and-optimization-program-is-a-scalable-model-to-improve-care-and-reduce-costs
#9
Michael J Englesbe, Dane R Grenda, June A Sullivan, Brian A Derstine, Brooke N Kenney, Kyle H Sheetz, William C Palazzolo, Nicholas C Wang, Rebecca L Goulson, Jay S Lee, Stewart C Wang
BACKGROUND: The Michigan Surgical Home and Optimization Program is a structured, home-based, preoperative training program targeting physical, nutritional, and psychological guidance. The purpose of this study was to determine if participation in this program was associated with reduced hospital duration of stay and health care costs. METHODS: We conducted a retrospective, single center, cohort study evaluating patients who participated in the Michigan Surgical Home and Optimization Program and subsequently underwent major elective general and thoracic operative care between June 2014 and December 2015...
February 4, 2017: Surgery
https://www.readbyqxmd.com/read/28173999/hepatic-parenchymal-transection-increases-liver-volume-but-not-function-after-portal-vein-embolization-in-rabbits
#10
Pim B Olthof, Erik Schadde, Krijn P van Lienden, Michal Heger, Kora de Bruin, Joanne Verheij, Roelof J Bennink, Thomas M van Gulik
BACKGROUND: Associating liver partition with portal vein ligation for staged hepatectomy induces more extensive liver hypertrophy than ligation alone; however, the mechanisms underlying the accelerated liver regrowth and the functional quality of the hypertrophic liver are presently elusive. This study, therefore, investigated the effect of parenchymal transection on liver volume and function after portal vein embolization in a standardized rabbit model. METHODS: Twelve rabbits were subjected to portal vein embolization of the cranial liver lobes and randomized between parenchymal transection of the left lateral liver lobe versus no transection (portal vein embolization only)...
February 4, 2017: Surgery
https://www.readbyqxmd.com/read/28161007/comment-on-upper-gastrointestinal-endoscopy-is-safe-and-feasible-in-the-early-postoperative-period-after-roux-en-y-gastric-bypass
#11
LETTER
Attila Csendes
No abstract text is available yet for this article.
February 1, 2017: Surgery
https://www.readbyqxmd.com/read/28161006/choosing-surgery-as-a-career-early-results-of-a-longitudinal-study-of-medical-students
#12
Anthony P Berger, Joseph C Giacalone, Patrick Barlow, Muneera R Kapadia, Jerrod N Keith
BACKGROUND: Few studies have explored the factors associated with the preference of medical students to pursue a specific specialty, and even fewer have observed how these preferences and factors change over time. METHODS: A longitudinal survey of medical students was administered at the beginning of first year, second year, and clerkships from 2013-2016. Surveys included demographics and factors associated with their choice of specialty. RESULTS: Response rates were 78-94%...
February 1, 2017: Surgery
https://www.readbyqxmd.com/read/28161005/surgery-investigators-funded-through-the-national-institutes-of-health-a-rebirth
#13
Yinin Hu, Brandy L Edwards, Kevin Hu, Kendall D Brooks, Craig L Slingluff
BACKGROUND: Funding toward surgical research through the National Institutes of Health has decreased relative to other medical specialties. This study was initiated to characterize features of academically successful surgeon-scientists and departments of surgery. We hypothesized that there may be decreases in young investigators obtaining independent National Institutes of Health awards and that successful academic departments of surgery may be depending increasingly on PhD faculty. METHODS: The National Institutes of Health RePORTER database was queried for grants awarded to departments of surgery during fiscal years 2003 and 2013...
February 1, 2017: Surgery
https://www.readbyqxmd.com/read/28159117/fecal-incontinence-treated-by-sacral-neuromodulation-long-term-follow-up-of-325-patients
#14
Paul T J Janssen, Sara Z Kuiper, Laurents P S Stassen, Nicole D Bouvy, Stephanie O Breukink, Jarno Melenhorst
BACKGROUND: Long-term results of large patient cohorts with fecal incontinence treated by sacral neuromodulation are limited. This study shows the long-term results after a mean follow-up of 7.1 years in 325 patients with fecal incontinence treated by continuous sacral neuromodulation. METHODS: All patients with fecal incontinence and eligible for sacral neuromodulation between 2000 and 2015 were evaluated retrospectively. Primary outcome was a decrease in episodes of fecal incontinence, which was defined as involuntary fecal loss at least once per week and documented by a 3 week bowel habit diary...
January 31, 2017: Surgery
https://www.readbyqxmd.com/read/28159116/development-of-a-new-biodegradable-operative-clip-made-of-a-magnesium-alloy-evaluation-of-its-safety-and-tolerability-for-canine-cholecystectomy
#15
Toshihiko Yoshida, Takumi Fukumoto, Takeshi Urade, Masahiro Kido, Hirochika Toyama, Sadaki Asari, Tetsuo Ajiki, Naoko Ikeo, Toshiji Mukai, Yonson Ku
BACKGROUND: Operative clips used to ligate vessels in abdominal operation usually are made of titanium. They remain in the body permanently and form metallic artifacts in computed tomography images, which impair accurate diagnosis. Although biodegradable magnesium instruments have been developed in other fields, the physical properties necessary for operative clips differ from those of other instruments. We developed a biodegradable magnesium-zinc-calcium alloy clip with good biologic compatibility and enough clamping capability as an operative clip...
January 31, 2017: Surgery
https://www.readbyqxmd.com/read/28153378/prediction-model-for-complications-after-low-anterior-resection-based-on-data-from-33-411-japanese-patients-included-in-the-national-clinical-database
#16
Toshiaki Watanabe, Hiroaki Miyata, Hiroyuki Konno, Kazushige Kawai, Soichiro Ishihara, Eiji Sunami, Norimichi Hirahara, Go Wakabayashi, Mitsukazu Gotoh, Masaki Mori
BACKGROUND: Low anterior resection is associated with a relatively high incidence of postoperative morbidities, including anastomotic leakage and other operative site infections, which sometimes result in postoperative mortality. Therefore, recognition of the incidence and risk factors of postoperative complications following low anterior resection is essential. METHODS: Data from the National Clinical Database on patients who had undergone low anterior resection in 2011 and 2012 were retrospectively analyzed...
January 30, 2017: Surgery
https://www.readbyqxmd.com/read/28143661/novel-therapy-for-pancreatic-fistula-using-adipose-derived-stem-cell-sheets-treated-with-mannose
#17
Hirokazu Kaneko, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tokunori Yamamoto, Rei Shibata, Momokazu Gotoh, Toyoaki Murohara, Akira Ito, Masato Nagino
BACKGROUND: Given that no studies have reported the use of adipose-derived stem cell sheets for the prevention of pancreatic fistulas, it is unclear whether adipose-derived stem cell sheets are effective at preventing this complication. The aim of this study was to evaluate the efficacy of novel therapy for the prevention of pancreatic fistulas using adipose-derived stem cell sheets treated with mannose. METHODS: The rat pancreatic duct (splenic duct) and surrounding pancreatic parenchyma were transected to induce a pancreatic fistula...
January 28, 2017: Surgery
https://www.readbyqxmd.com/read/28143660/proteomics-based-analysis-of-lung-injury-induced-proteins-in-a-mouse-model-of-common-bile-duct-ligation
#18
Tomohisa Sakaue, Fumiaki Shikata, Kaho Utsunomiya, Shunya Fukae, Mie Kurata, Hirotomo Nakaoka, Mikio Okazaki, Yujiro Kawanishi, Ai Kojima, Shigeki Higashiyama, Hironori Izutani
BACKGROUND: Lung injury is a life-threatening complication in patients with liver dysfunction. We recently provided an experimental lung injury model in mouse with common bile duct ligation. In this study, we aimed to characterize the pathologic and biochemical features of lung tissues in common bile duct ligation mice using a proteomic approach. METHODS: Common bile ducts of BALB/c mice, 8 weeks of age, were ligated operatively. CD31-expressing pulmonary cells were sorted with immunomagnetic microbeads, and protein profiles were examined by 2-dimensional gel electrophoresis...
January 28, 2017: Surgery
https://www.readbyqxmd.com/read/28139243/pancreas-containing-inguinal-hernia-in-an-adult-with-intestinal-malrotation
#19
David H Ballard, Guillermo P Sangster
No abstract text is available yet for this article.
January 27, 2017: Surgery
https://www.readbyqxmd.com/read/28139242/the-effect-of-perioperative-fluid-management-on-postoperative-ileus-in-rectal-cancer-patients
#20
Matthew S VandeHei, Christina M Papageorge, Matthew M Murphy, Gregory D Kennedy
BACKGROUND: Postoperative ileus is a common cause of increased morbidity and cost after operative intervention. The aim of this study was to assess how fluid type, volume, and timing may affect incidence of postoperative ileus. METHODS: A retrospective cohort study was performed on patients undergoing operative intervention for rectal cancer from 2008 to 2015 at a single institution. Univariate and multivariate analyses were used to assess the effect of type (crystalloid versus colloid), volume by quartile, and timing (perioperative versus postoperative) on rate of postoperative ileus...
January 27, 2017: Surgery
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