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Surgical Oncology

Richard J Cassidy, Jeffrey M Switchenko, Melinda L Yushak, Nicholas Madden, Mohammad K Khan, David K Monson, Jonathan J Beitler, Jerome C Landry, Karen D Godette, Theresa W Gillespie, Kirtesh R Patel
BACKGROUND: Scalp angiosarcomas (SA) are rare, representing <1% of soft tissue sarcomas. The optimal management of these tumors is unknown, with management based on small case series. We sought to assess the impact of different therapies on overall survival (OS), the practice patterns nationally, and identify factors associated with OS for non-metastatic scalp angiosarcomas. METHODS: A prospectively maintained database was used to identify non-metastatic scalp angiosarcomas who received some form of definitive therapy...
September 13, 2018: Surgical Oncology
Frederick L Greene
No abstract text is available yet for this article.
July 4, 2018: Surgical Oncology
Kuo-Feng Hsu, Jyh-Cherng Yu, Chih-Wei Yang, Bao-Chung Chen, Cheng-Jueng Chen, De-Chuan Chan, Hsiu-Lung Fan, Teng-Wei Chen, Yu-Lueng Shih, Tsai-Yuan Hsieh, Chung-Bao Hsieh
BACKGROUND: In contrast to the feasibility of hepatectomy for resectable large hepatocellular carcinoma (HCC, >5 cm) in the younger patients, the concerns of benefits for the elderly patients remain in practice. This study aimed to evaluate the long-term outcomes and safety after hepatectomy in elderly patients with resectable large HCC compared with younger patients. METHODS: Between 2003 and 2014, a total of 2211 HCC patients were reviewed using a prospective database and 257 patients with resectable large HCC undergoing hepatectomy were included: 79 elderly patients with age ≥70 years and 178 younger patients with age <70 years...
September 2018: Surgical Oncology
Elise Piraux, Gilles Caty, Gregory Reychler
BACKGROUND: Surgical management remains the cornerstone of treatment for many cancers, but is associated with a high rate of postoperative complications, which are linked to poor preoperative functional capacity. Prehabilitation may have beneficial effects on functional capacity and postoperative outcomes. We evaluated the effects of prehabilitation combining endurance and resistance training (CT) on physical fitness, quality of life (QoL) and postoperative outcomes in cancer patients undergoing tumour resection surgery...
September 2018: Surgical Oncology
Alberto Biondi, Annamaria Agnes, Federica Del Coco, Carmelo Pozzo, Antonia Strippoli, Domenico D'Ugo, Roberto Persiani
BACKGROUND: The administration of perioperative chemotherapy represents the Western standard of care for patients with locally advanced gastric cancer. The aim of this study is to determine if the administration of the preoperative component of the perioperative regimen is beneficial in the entire population of patients with locally advanced gastric cancer. METHODS: Seventy patients undergoing preoperative therapy were compared with 347 patients undergoing upfront gastrectomy...
September 2018: Surgical Oncology
Zhaolun Cai, Yuan Yin, Chaoyong Shen, Jian Wang, Xiaonan Yin, Zhixin Chen, Ye Zhou, Bo Zhang
BACKGROUND: Different preoperative, postoperative or perioperative treatment strategies, including chemotherapy or chemoradiotherapy, are available for patients with gastric cancer, but conventional meta-analyses that assess two alternative treatments are unable to compare differences in overall survival. Thus, we performed a network meta-analysis to identify the best treatment strategy. METHODS: We systematically searched and assessed studies for eligibility and extracted data...
September 2018: Surgical Oncology
Jianqiao Cao, Ting Yang, Guanhua Wang, Hongfei Zhang, Yanjie You, Jing Chen, Jingwen Yang, Wenjun Yang
OBJECTIVE: To explore the clinicopathological features and prognostic factors of 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction (AEG). METHODS: In total, 734 patients were confirmed to have AEG by gastroscopy and pathology at the General Hospital of Ningxia Medical University between January 2002 and December 2012. Univariate and multivariate analyses of demographic, clinicopathological, and prognostic data were performed...
September 2018: Surgical Oncology
Dorian Yarih García-Ortega, Alethia Álvarez-Cano, Luis Adolfo Sánchez-Llamas, Claudia H S Caro-Sanchez, Héctor Martínez-Said, Kuauhyama Luna-Ortiz, Mario Cuéllar-Hübbe
BACKGROUND: Synovial sarcoma is a rare malignant soft tissue tumor, more common in adolescents and young adults and entails a poor prognosis. Several good prognostic factors have been well established such as age less than 25, size less than 5 cm and absence of a poorly differentiated component. Inflammation has a well-established role in tumor proliferation and survival. The aim of this study was to investigate the prognostic significance of the neutrophil/lymphocyte ratio (NLR) in a large cohort of synovial sarcoma patients...
September 2018: Surgical Oncology
M J L Mastboom, F G M Verspoor, D F Hanff, M G J Gademan, P D S Dijkstra, H W B Schreuder, J L Bloem, R J P van der Wal, M A J van de Sande
AIM: Current development of novel systemic agents requires identification and monitoring of extensive Tenosynovial Giant Cell Tumours (TGCT). This study defines TGCT extension on MR imaging to classify severity. METHODS: In part one, six MR parameters were defined by field-experts to assess disease extension on MR images: type of TGCT, articular involvement, cartilage-covered bone invasion, and involvement of muscular/tendinous tissue, ligaments or neurovascular structures...
September 2018: Surgical Oncology
Zhangfan Mao, Bo Wang, Ping Dong, Jie Huang
OBJECTIVE: It is a significant surgical challenge to reconstruct esophagus for the patients following distal gastrectomy (DGE). Remnant stomach seems to be a better choice compared with colon or jejunal. But many complicated surgical methods were performed because of limitation of feeding vessels. We found the remnant stomach remained viable when all the feeding vessels were dissected. We used the completely mobilized stomach to reconstruct esophagus successfully in 29 lower thoracic esophageal carcinoma patients with a history of DGE...
September 2018: Surgical Oncology
Lina Song, Guanglei Qiao, Yingjie Xu, Lijun Ma, Weihua Jiang
The long-time paradoxical situation of non-coding RNAs (ncRNAs) has been terminated for they emerge as executive at full spectrum of gene expression and translation. More recently, it has been demonstrated that some ncRNAs apparently are associated with chemotherapy, causing cardiotoxicity, which taint long-term recovery of patients in growing body of evidence. The current review focused on up-to-date knowledge on regulation change and molecular signaling of ncRNAs, at mean time evaluate their potentials as diagnostic biomarkers or therapeutic targets to monitor and protect cardio function...
September 2018: Surgical Oncology
Nigel D'Souza, Michael P M de Neree Tot Babberich, Amy Lord, Annabel Shaw, Muti Abulafi, Paris Tekkis, Theo Wiggers, Gina Brown
The lack of consensus over the transition point for the end of the sigmoid and beginning of the rectum is a problem for the colorectal multidisciplinary team. In this review, we survey the wide number of landmarks for the rectosigmoid junction, and describe the theoretical and evidence-based strengths and weaknesses of each one. Without a reliable definition of the rectum, sigmoid and rectal cancers will be classified inconsistently. As the treatment strategies for sigmoid and rectal cancers are radically different, incorrect tumour localisation has a substantial impact on patient management, leading to under or over treatment...
September 2018: Surgical Oncology
Se Ik Kim, Ranah Kim, Jisu Seong, Hee Seung Kim
BACKGROUND: Primary yolk sac tumor (YST) of the vulva is extremely rare and only introduced in case reports [1]. For those, routine inguinal lymph node dissection (LND) in absence of palpable inguinal lymph node is questionable. To avoid complications of inguinal LND, such as lymphedema, inguinal sentinel lymph node biopsy (SLNB) can be considered [2,3]. Since recent studies reported feasibility of robot-assisted inguinal lymphadenectomy [4], we showed the surgical procedures of robot-assisted inguinal SLNB...
September 2018: Surgical Oncology
Kyung Jin Eoh, Yong Jae Lee, Hyun-Soo Kim, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim
OBJECTIVE: The current sentinel lymph node (SLN) tracer injection procedure for endometrial cancer commonly uses cervical injection, which can detect SLNs of the uterine cervix but not the uterine body. This study describes an SLN tracer injection procedure, titled two-step SLN mapping, which can identify SLNs of the uterine body and cervix using fluorescent imaging with indocyanine green (ICG) and results of SLN biopsy. METHODS: In 50 consecutive patients with endometrial cancer, two-step SLN mapping was performed during laparoscopic surgical staging with the PINPOINT® real-time fluorescence imaging system...
September 2018: Surgical Oncology
T Hauck, R E Horch, M Schmitz, A Arkudas
INTRODUCTION: Breast reconstruction is an important element in the successful therapy of breast cancer [1]. Thereby, autologous microvascular breast reconstruction has been shown to be a reliable technique. The use of a deep inferior epigastric perforator (DIEP) flap or a muscle-sparing (MS) free transverse rectus abdominis musculocutaneous (TRAM) flap is recognized in many centres as gold standard for reconstructive options [2-4]. Based on our experiences with 137 patients over a 5-year period we want to highlight the technical aspects of the free microsurgical autologous breast reconstruction using a DIEP flap...
September 2018: Surgical Oncology
Michael Vaiman, Ariel Halevy, Mehrzad Cohenpour, Michael Peer, Inessa Bekerman, Haim Gavriel
BACKGROUND: We investigated the management of thyroid incidentalomas associated with cases of parathyroid lesions in order to suggest a practical approach to their management from a surgical point of view. METHODS: 639 patients underwent radiological and ultrasound investigation of the thyroid area because of parathyroid disorders and parathyroidectomy and had at least three years of follow-up. All follow-up data for these cases were investigated from the moment the lesion was detected and up to the last report...
September 2018: Surgical Oncology
Vincenzo Abbate, Giovanni Dell'Aversana Orabona, Giovanni Salzano, Paola Bonavolontà, Fabio Maglitto, Antonio Romano, Filippo Tarabbia, Mario Turri-Zanoni, Federica Attanasi, Alessandro Espedito Di Lauro, Giorgio Iaconetta, Luigi Califano
BACKGROUND: Optimum management of clinically negative neck (cN0) remains controversial in early stage (T1-T2) squamous cell cancer of the oral tongue (OTSCC). The purpose of this study was to investigate the value of pre-treatment Neutrophil-to lymphocyte ratio (NLR) in predicting occult cervical metastasis in stage I and II OTSCC. METHODS: We carried out a retrospective chart review on 110 patients suffering from early stage OTSCC who were surgically treated with tumour excision and elective neck dissection (END)...
September 2018: Surgical Oncology
Hongying Zhao, Jianjun Xu, Yu Wang, Rongke Jiang, Xue Li, Lili Zhang, Yingqi Che
Gastric cancer directly affects the quality of human life worldwide. Some members, which belong to carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily, are deregulated in tumors. Of the subfamily, CEACAM19, a new member was the research object. Our study sought to explore the potential role of CEACAM19 in gastric cancer. According to the immunohistochemistry (IHC), RT-PCR and Western blot, CEACAM19 was over-expressed in gastric cancer tissues and cells. Moreover, the Western blot analysis showed that the expression of MMP2 and MMP9 was inhibited in CEACAM19 knockdown gastric cancer cells...
September 2018: Surgical Oncology
Akira Ohkoshi, Takenori Ogawa, Ayako Nakanome, Eiichi Ishida, Ryo Ishii, Kengo Kato, Yukio Katori
OBJECTIVE: Surgery for locally advanced oral cancer often requires wide resections of multiple subsites of the oral cavity, including the oral tongue, floor of the mouth, and lower gingiva, and it causes chewing and swallowing disorders. The aim of this prospective, observational study was to determine which subsites have a greater impact on chewing and swallowing disorders after surgery. METHODS: A prospective, observational study was conducted involving 52 patients who underwent surgery for locally advanced oral cancer with free flap reconstruction...
September 2018: Surgical Oncology
Levent Korkmaz, Hasan Şenol Coşkun, Faysal Dane, Bülent Karabulut, Mustafa Karaağaç, Devrim Çabuk, Senem Karabulut, Nuri Faruk Aykan, Hatice Doruk, Nilüfer Avcı, Nazım Serdar Turhal, Mehmet Artaç
PURPOSE: We aimed to investigate the prognostic effect of primary tumor resection (PTR) prior to bevacizumab-based treatments in unresectable metastatic colorectal cancer (mCRC). METHODS: We retrospectively collected 341 mCRC cases with unresectable metastases at diagnosis. PTR was performed in 210 cases (the surgery group) and the other patients (n = 131) were followed without PTR (the no-surgery group). All the patients were treated with bevacizumab combined chemotherapy regimens...
September 2018: Surgical Oncology
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