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Surgical Oncology

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https://www.readbyqxmd.com/read/29549911/impact-of-breast-mri-in-women-eligible-for-breast-conservation-surgery-and-intra-operative-radiation-therapy
#1
Nitika Paudel, Kevin P Bethke, Lilian C Wang, Jonathan B Strauss, John P Hayes, Eric D Donnelly
PURPOSE: The current standard of care for women diagnosed with early stage breast cancer is breast-conserving surgery (BCS) followed by external beam radiation therapy, commonly delivered over 3-6 weeks. As an alternative, select patients can undergo intra-operative radiation therapy (IORT) at the time of BCT. This technique delivers a single fraction of radiation at the time of surgery, enabling patients to undergo both surgery and radiation in a single session. Our current study analyzed the value of incorporating breast MRI into the routine work-up of patients deemed eligible for IORT, to quantify the impact on patient eligibility and requirement for additional work-up...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549910/association-of-preoperative-serum-crp-with-pd-l1-expression-in-508-patients-with-non-small-cell-lung-cancer-a-comprehensive-analysis-of-systemic-inflammatory-markers
#2
Takaki Akamine, Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yasuto Yoneshima, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Yoichi Nakanishi, Yoshihiko Maehara
OBJECTIVES: Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors have been approved as a standard therapy for metastatic non-small cell lung cancer (NSCLC). Although PD-L1 expression serves as a predictive biomarker for the efficacy of immunotherapy, there are no established biomarkers to predict the expression of PD-L1. The inflammatory markers C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were recently shown to predict the efficacy of nivolumab for NSCLC patients...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549909/impact-of-preoperative-endoscopic-cholangiography-and-biliary-drainage-in-ampulla-of-vater-cancer
#3
Keun Soo Ahn, Koo Jeong Kang, Yong Hoon Kim, Yoon Suk Lee, Gwang Bum Cho, Tae-Seok Kim, Jung Woo Lee
BACKGROUND: Ampulla of Vater (AOV) carcinoma is a rare malignancy but has a relatively good prognosis. The aims of this study were to determine the clinicopathologic factors associated with survival and disease recurrence in patients with AOV cancer, focusing on the impact of preoperative endoscopic retrograde cholangiopancreatography (ERCP) and type of biliary drainage (endoscopic retrograde biliary drainage [ERBD] or percutaneous transhepatic biliary drainage [PTBD]). METHODS: We retrospectively reviewed the medical records of 80 patients who underwent curative resection for AOV cancer at a single institution between 1995 and 2015...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549908/ten-eleven-translocation-1-tet1-gene-is-a-potential-target-of-mir-21-5p-in-human-colorectal-cancer
#4
Ya-Wen Cheng, Chia-Jung Chou, Pei-Ming Yang
DNA 5-methylcytosine (5-mC) methylation, a key epigenetic mark, is critical for biological and pathological processes. Aberrant DNA methylation occurs in all tumor types and correlates with tumor suppressor gene silencing. DNA methylation is thought to be very stable, and active DNA demethylation remains a long-standing enigma. Recently, the ten-eleven translocation (TET) family of oxygenases are found to oxidize 5-mC to 5-hydroxymethylcytosine (5-hmC), which is prerequisite for active DNA demethylation. Both TET1 expression and global 5-hmC content are significantly reduced in colorectal cancer (CRC), the top leading cause of cancer-related death in the world...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549907/how-to-conduct-a-high-quality-systematic-review-on-diagnostic-research-topics
#5
REVIEW
Xiaomei Yao, Emily Vella, Melissa Brouwers
The methodological rigour of original studies on a diagnostic or prognostic research topic, and systematic reviews of these primary studies, varies; improving overall quality is warranted. This paper, the second of the series, outlines key concepts and essential steps required to conduct a high-quality systematic review on diagnostic topics. It is comprised of six aspects: clarifying the project objectives; generating an appropriate research question; searching the literature and selecting study criteria; assessing risk of bias of eligible studies, reporting and analyzing data, and interpreting data and making conclusions...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549906/prediction-of-survival-in-patients-with-symptomatic-spinal-metastases-comparison-between-the-tokuhashi-score-and-expert-oncologists
#6
Kenny Yat Hong Kwan, Tai Chung Lam, Horace Cheuk Wai Choi, Hui Yu Koh, Kenneth Man Chee Cheung
BACKGROUND: Existing scoring systems have suboptimal accuracy in prognosticating patients with spinal metastases. Currently, there is no superior method in predicting survival. This study aims to compare the accuracy of survival prediction by expert oncologists versus the revised Tokuhashi scores with actual survivals in a cohort of symptomatic spinal metastases patients. METHODS: All patients who underwent surgical treatment for metastatic spinal tumours in a tertiary hospital between January 2011 to December 2015 were reviewed...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549905/the-impact-of-acute-inflammation-on-progression-and-metastasis-in-pancreatic-cancer-animal-model
#7
Keun Soo Ahn, Ji Yeon Hwang, Ho-Seong Han, Sang Tae Kim, Ilseon Hwang, Young-Ok Chun
BACKGROUND: The impact of acute inflammation on cancer is unclear. Therefore, we evaluated the impact of acute inflammation on cancer progression in an animal model concerning morphological change as well as molecular features. MATERIAL AND METHODS: Murine pancreas ductal adenocarcinoma cell line (Panc-02) and zymosan were used for the induction of cancer and acute inflammation respectively, in C57/BL6 mice. In the C group (n = 10), 2 × 107 Panc02 cells were injected into the tail of the pancreas...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549904/preoperative-lymph-node-size-is-helpful-to-predict-the-prognosis-of-patients-with-stage-iii-gastric-cancer-after-radical-resection
#8
Xin-Chang Shang-Guan, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Chang-Ming Huang, Chao-Hui Zheng
OBJECTIVE: To investigate the association between preoperative lymph node size (Ns) and prognosis of radical gastrectomy for gastric cancer. METHODS: The clinical and pathological data of 970 patients undergoing radical gastrectomy for gastric cancer were retrospectively analyzed. The correlation between Ns and the identified variables for the prediction of overall survival (OS) and disease-free survival (DFS) was examined. RESULTS: Three hundred and thirty-one (34...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549903/metastases-to-the-parotid-gland-a-review-of-the-clinicopathological-evolution-molecular-mechanisms-and-management
#9
REVIEW
James Badlani, Ruta Gupta, Joel Smith, Bruce Ashford, Sydney Ch'ng, Michael Veness, Jonathan Clark
Metastases to the parotid gland are the commonest cause of parotid malignancies in many regions of the world including Australia. The most common etiology of these metastases is head and neck cutaneous squamous cell carcinoma (HNcSCC) followed by melanoma of the head and neck. This article focuses on the management of the aforementioned pathologies including Merkel cell carcinoma (MCC).
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549902/the-optimal-lymph-node-dissection-in-patients-with-adenocarcinoma-of-the-esophagogastric-junction
#10
Cecilie Okholm, Kaare Terp Fjederholt, Frank Viborg Mortensen, Lars Bo Svendsen, Michael Patrick Achiam
OBJECTIVE: The aim of this study was to refine the optimal lymph node dissection in Western patients with adenocarcinoma of the esophagogastric junction (AEG). BACKGROUND: Lymphadenectomy is essential in addition to surgery for AEG. Asian studies continually present superior survival rates using a more extended lymphadenectomy compared with results reproduced in the West. Thus, the optimal extend of the lymphadenectomy remains unclear in Western patients. METHODS: A retrospective cohort was conducted of patients with AEG from January 1st, 2003 to December 31st, 2011...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549901/outcomes-of-major-laparoscopic-liver-resection-for-hepatocellular-carcinoma
#11
Hanisah Guro, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, YoungRok Choi, Sungho Kim, Kilhwan Kim, In Gun Hyun
BACKGROUND: To compare the surgical outcomes of major laparoscopic liver resection (LLR) and open liver resection (OLR) for hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed the medical records of 177 patients who underwent major liver resection for HCC between January 2004 and June 2015. We divided the 177 patients into two groups according to the type of procedure: major LLR (LLR group; n = 67) and major OLR (OLR group; n = 110). RESULTS: Procedures in the LLR group were right hepatectomy (30 patients), right posterior sectionectomy (28), left hepatectomy (11), right anterior sectionectomy (6), extended right hepatectomy (6), and central bisectionectomy (2)...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549900/long-term-quality-of-life-and-psycho-social-outcomes-after-oropharyngeal-cancer-surgery-and-radial-forearm-free-flap-reconstruction-a-gettec-prospective-multicentric-study
#12
Alexandre Bozec, Pierre Demez, Jocelyn Gal, Emmanuel Chamorey, Marie-Yolande Louis, David Blanchard, Dominique De Raucourt, Jean-Claude Merol, Esteban Brenet, Olivier Dassonville, Gilles Poissonnet, José Santini, Frédéric Peyrade, Karen Benezery, Maria Lesnik, Etienne Berta, Pierre Ransy, Emmanuel Babin
OBJECTIVE: To assess long-term quality of life (QoL) and psycho-social outcomes, and to determine their predictive factors after oropharyngeal cancer (OPC) surgery and radial forearm free-flap (RFFF) reconstruction. METHODS: Patients who had undergone OPC surgery and RFFF reconstruction who were still alive and disease-free at least 1 year after surgery were enrolled in this prospective multicentric study. Patients completed the European Organization for Research and Treatment of Cancer (EORTC) Core (QLQ-C30) and Head and Neck Cancer (QLQ-H&N35) QoL questionnaires, the Voice Handicap Index (VHI-10) questionnaire and the Hospital Anxiety and Depression Scale (HADS)...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549899/factors-related-to-improved-clinical-outcomes-associated-with-adrenalectomy-for-metachronous-adrenal-metastases-from-solid-primary-carcinomas
#13
Jae Won Cho, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong
BACKGROUND: Surgery for metachronous adrenal metastases from solid primary carcinoma has increased with the development of technical skills. Here we analyzed the postoperative clinical outcomes of patients who underwent adrenalectomy for metachronous adrenal metastases from solid primary carcinomas. METHODS: Patients who underwent adrenalectomy for metachronous adrenal metastases after initial treatment of primary carcinoma at Asan Medical Center from 2000 to 2010 were included...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549898/sentinel-lymph-node-biopsy-in-merkel-cell-carcinoma-the-mayo-clinic-experience-of-150-patients
#14
John R Sims, Travis E Grotz, Barbara A Pockaj, Richard W Joseph, Robert L Foote, Clark C Otley, Amy L Weaver, James W Jakub, Daniel L Price
BACKGROUND: Merkel cell carcinoma (MCC) is a rare cutaneous malignancy of neuroendocrine origin with a high propensity for lymph node metastasis. Sentinel lymph node (SLN) status is important for accurate staging; however, the optimal treatment following SLN biopsy, regardless of nodal status, remains unclear. METHODS: 150 patients with MCC who underwent SLN biopsy from 1995 to 2011 at 3 Mayo Clinic sites were reviewed. RESULTS: Of 150 patients with MCC who underwent SLN biopsy, 39 (26%) were positive and 111 (74%) were negative...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549897/detection-of-ret-rearranged-during-transfection-variants-and-their-downstream-signal-molecules-in-ret-rearranged-lung-adenocarcinoma-patients
#15
Jeong-Oh Kim, Jung-Young Shin, Min Young Kim, Kyoung Hwa Son, Chan Kwon Jung, Tae-Jung Kim, Su Young Kim, Jae Kil Park, Sook Whan Sung, Sang Ju Bae, Hyun Jung Min, Jin-Hyoung Kang
BACKGROUND: We screened resected tumor tissues from patients with lung cancer for EGFR mutations, ALK rearrangements, and rearranged during transfection (RET) gene variants (including RET rearrangements and the Kinesin Family Member 5B (KIF5B)-RET fusion gene) using various methods including reverse transcription polymerase chain reaction (RT-PCR), transcript assays, fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). We also examined the protein expression of associated downstream signaling molecules to assess the effect of these variants on patient outcome...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549896/application-of-the-8th-edition-of-the-ajcc-ytnm-staging-system-shows-improved-prognostication-in-a-single-center-cohort-of-esophageal-carcinomas
#16
Dino Kröll, Laura Noser, Suna Erdem, Federico Storni, Dominik Arnold, Bastian Dislich, Inti Zlobec, Daniel Candinas, Christian A Seiler, Rupert Langer
BACKGROUND: The 8th edition of the AJCC TNM staging system presents for the first time a specific classification for esophageal carcinomas treated with neoadjuvant therapy (yTNM8). In this single center study, we applied the novel staging system in a "real life" case series and compared the prognostic value of yTNM8 with the preceding 7th edition (TNM7). METHODS: Out of 272 consecutive esophageal carcinomas that were treated during a 15-year period in one surgical center, all 198 cases that had undergone neoadjuvant therapy were reviewed and classified according to TNM7 and yTNM8...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29549895/the-prevalence-of-lymph-node-metastasis-for-pathological-t1-esophageal-cancer-a-retrospective-study-of-143-cases
#17
Xiao-Feng Duan, Peng Tang, Xiao-Bin Shang, Hong-Jing Jiang, Zhen-Tao Yu
OBJECTIVE: To evaluate the prevalence, pattern and risk factors of lymph node metastasis (LNM) for pathological T1 (pT1) esophageal cancer (EC). METHODS: The clinical data of 143 cases of pT1 patients who underwent esophagectomy and lymph node dissection during January 2011 and July 2016 were reviewed, including 120 male patients and 23 female patients with a median age of 60 years. The pattern of LNM was analyzed and the risk factors related to LNM were assessed by logistic regression analysis...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29454736/editorial-march-issue-surgical-oncology
#18
EDITORIAL
Vijay P Khatri, Nicholas J Petrelli
No abstract text is available yet for this article.
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29397259/minimally-invasive-hepatopancreatobiliary-surgery-where-do-we-go-from-here
#19
Jordan M Cloyd, Timothy M Pawlik
No abstract text is available yet for this article.
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29371066/international-summit-on-laparoscopic-pancreatic-resection-islpr-coimbatore-summit-statements
#20
Chinnusamy Palanivelu, Kyoichi Takaori, Mohammad Abu Hilal, David A Kooby, Go Wakabayashi, Anil Agarwal, Stefano Berti, Marc G Besselink, Kuo Hsin Chen, Andrew A Gumbs, Ho-Seong Han, Goro Honda, Igor Khatkov, Hong Jin Kim, Jiang Tao Li, Tran Cong Duy Long, Marcel Autran Machado, Akira Matsushita, Krish Menon, Zheng Min-Hua, Masafumi Nakamura, Yuichi Nagakawa, Juan Pekolj, Ignasi Poves, Shahidur Rahman, Liu Rong, Antonio Sa Cunha, Palanisamy Senthilnathan, Shailesh V Shrikhande, S Srivatsan Gurumurthy, Dong Sup Yoon, Yoo-Seok Yoon, Vijay P Khatri
The International Summit on Laparoscopic Pancreatic Resection (ISLPR) was held in Coimbatore, India, on 7th and 8th of October 2016 and thirty international experts who regularly perform laparoscopic pancreatic resections participated in ISPLR from four continents, i.e., South and North America, Europe and Asia. Prior to ISLPR, the first conversation among the experts was made online on August 26th, 2016 and the structures of ISPLR were developed. The aims of ISPLR were; i) to identify indications and optimal case selection criteria for minimally invasive pancreatic resection (MIPR) in the setting of both benign and malignant diseases; ii) standardization of techniques to increase the safety of MIPR; iii) identification of common problems faced during MIPR and developing associated management strategies; iv) development of clinical protocols to allow early identification of complications and develop the accompanying management plan to minimize morbidity and mortality...
March 2018: Surgical Oncology
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