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Surgical Oncology

Andrea Celotti, Giuseppe D'Amico, Marco Ceresoli, Matteo Tomasoni, Stefano Raimondo, Paolo Baggi, Gian Luca Baiocchi
Hepatoblastoma is the most common malignant liver tumor in children. On the other hand in the adult HB is very rare and characterized by unfavorable prognosis. A review of the entire literature was performed: 58 articles and 63 cases of HB were found. The patient's data were collected and analyzed. No correlation with hepatitis virus was found and AFP was elevated in most cases. Usually HB forms a large single mass in the liver and presents aggressive behavior, with local invasiveness and metastatic spread...
September 2016: Surgical Oncology
Nikolaos Andreatos, Sean Ronnekleiv-Kelly, Georgios A Margonis, Kazunari Sasaki, Faiz Gani, Neda Amini, Ana Wilson, Timothy M Pawlik
INTRODUCTION: While the role of KRAS in the molecular genetics of colorectal cancer has been studied extensively, its prognostic impact in colorectal liver metastases (CRLM) has only recently been examined. This review aimed to summarize currently reported findings on the clinical implications of KRAS mutant (mut-KRAS) status for patients with CRLM. MATERIALS AND METHODS: The Pubmed database was searched for relevant articles published from 01/01/2010 to 02/01/2016...
September 2016: Surgical Oncology
Anne-Lucie Dessapt, Cyrille Huchon, Charlotte Ngo, Anne-Sophie Bats, Chérazade Bensaid, Fabrice Lecuru
BACKGROUND: Post-operative residual tumor size is the main prognostic factor in advanced epithelial ovarian cancer. Our objective was to develop a score for predicting the feasibility of complete cytoreductive surgery in patients with advanced epithelial ovarian cancer. MATERIAL AND METHODS: Using data from a retrospective cohort of 123 patients with advanced ovarian cancer, we developed a score for predicting complete cytoreductive surgery, by performing multiple logistic regression after a jackknife procedure...
September 2016: Surgical Oncology
B A Krasnick, S D Nathanson, C N Arbabi, D A Chitale, E L Peterson
BACKGROUND: Breast cancer sentinel lymph nodes (SLNs) with metastases (mets) are often palpably enlarged. We hypothesized that the volume of the SLN and the size of mets are directly related. SLNs harboring mets are often firm, with increased intra-nodal pressure (INP), and we hypothesized that SLN volume, as well as INP, would correlate directly with SLN metastasis size. METHODS: The SLN volume, INP and met size were measured in 296 SLNs and compared using linear regression analysis...
September 2016: Surgical Oncology
Sarah J Valle, Nayef Alzahrani, Saleh Alzahrani, Thamer Bin Traiki, Winston Liauw, David L Morris
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an effective treatment for peritoneal carcinomatosis (PC) from multiple origins, however is associated with increased complications compared to conventional gastrointestinal surgery. The aetiology of enterocutaneous fistulas (ECF) in most cases is a result of various contributing factors and therefore remains a major clinical problem, occurring in 4-34% of patients post-CRS. The aim of this study was to analyze the incidence and outcome of ECF following CRS/HIPEC...
September 2016: Surgical Oncology
Ioannis Kyriazanos, Vasileios Kalles, Anastasios Stefanopoulos, John Spiliotis, Faheez Mohamed
Cytoreductive surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is increasingly used in the treatment of peritoneal malignancies. The administration of HIPEC after complete cytoreduction offers the combination of the pharmacokinetic advantages inherent to the intraperitoneal delivery of cytotoxic chemotherapy, with the direct cytotoxic effects of hyperthermia, and has been reported to offer significantly improved patient outcomes. As a result, this novel method disseminates rapidly, with many surgical teams having developed peritoneal malignancy treatment programs...
September 2016: Surgical Oncology
Kim M C van Mierlo, Junfang Zhao, Jos Kleijnen, Sander S Rensen, Frank G Schaap, Cornelis H C Dejong, Steven W M Olde Damink
BACKGROUND DATA: Hepatic sinusoidal dilatation (SD) is a histopathological entity that occurs in up to 75% of patients undergoing oxaliplatin-based chemotherapy for colorectal liver metastases (CRLM). OBJECTIVE: To study the influence of SD on outcome after partial hepatectomy in patients with CRLM. METHODS: Medline, Embase, CENTRAL, LILACS and CINAHL were searched for studies published between 01.01.2004 and 09.06.2015 with keywords: "sinusoidal obstruction syndrome", "hepatic veno-occlusive disease", and "Stuart-Bras syndrome"...
September 2016: Surgical Oncology
Linda S Yang, Bernard L Shan, Leonard L Shan, Peter Chin, Spencer Murray, Nariman Ahmadi, Akshat Saxena
BACKGROUND: Radical cystectomy and urinary diversion is the treatment of choice for invasive bladder cancer. Quality of life (QOL) is an important outcome of surgery. This review compares the QOL after continent and incontinent urinary diversion in radical cystectomy for patients with primary invasive bladder cancer. METHODS: A systematic review and meta-analysis of clinical studies published after January 2000 was performed according to the PRISMA guidelines. Quality appraisal and data tabulation were performed using pre-determined forms...
September 2016: Surgical Oncology
Marcello Donati, Gregor A Stavrou, Axel Stang, Francesco Basile, Karl J Oldhafer
No abstract text is available yet for this article.
September 2016: Surgical Oncology
S L Due, D I Watson, I Bastian, G Q Ding, O A Sukocheva, D St J Astill, L Vat, D J Hussey
INTRODUCTION: Esophageal adenocarcinoma is a lethal malignancy which is increasing in incidence, and many patients receive chemotherapy as part of their treatment. We have previously demonstrated that esophageal adenocarcinoma-derived cell lines respond to treatment with estrogen receptor modulators, such as tamoxifen. Reports from breast cancer suggest that tamoxifen may attenuate the efficacy of other chemotherapeutic agents. We have therefore assessed the response of esophageal adenocarcinoma cell lines to tamoxifen therapy when given in combination with conventional agents...
September 2016: Surgical Oncology
A Morice, A Ostertag, M Sahli-Amor, P Goudot, C Bertolus, T Schouman
OBJECTIVES: To determine prognostic factors in gingivo-alveolar squamous cell carcinoma of the maxilla (GA-SCC-M), and particularly the prognostic value of both vertical and antero-posterior tumor spread. MATERIAL AND METHODS: Our retrospective study included all naïve-treatment patients treated in our center between 2006 and 2013 for GA-SCC-M. Posterior involvement was considered when the tumor extended behind the mesial side of the first maxillary molar. Spread posterior to the maxillary tuberosity was defined by the spread to at least one of the following structures: pterygomaxillary fissure, pterygoid muscles, and processes...
September 2016: Surgical Oncology
Nam Kyu Kim, Young Wan Kim, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee
Classic colon cancer surgery refers to a wide resection of the tumor-bearing segment and the lymphatics draining along the named artery. The concept of TME has been applied to colon cancer and complete mesocolic excision (CME) in conjuction with central vascular ligation (CVL) has been introduced as the surgical treatment for colon cancer. Here, we discuss appropriate CME procedure with regard to the oncologic backgrounds, essential components, applied anatomy, laparoscopic technique, short-term, and oncologic outcomes...
September 2016: Surgical Oncology
Samir Pathak, Sanjay Pandanaboyana, Ian Daniels, Neil Smart, K R Prasad
Colorectal cancer (CRC) is the third commonest malignancy after lung and breast cancer. The most common cause of mortality from CRC is from distant metastases. Obesity is a known risk factor for primary CRC development. However, its role in metastatic disease progression is not fully understood. The article aims to provide an overview of the role of obesity in colorectal liver metastases (CRLM). Furthermore, possible strategies to minimise this effect are discussed. An electronic search of MedLine, EMBASE, CINAHL and google scholar was performed...
September 2016: Surgical Oncology
Maria Saltari, Giacomo Corrado, Lodovico Patrizi, Enrico Vizza
No abstract text is available yet for this article.
September 2016: Surgical Oncology
Gang Zhang, Xian-Jun Zhou, Cheng-Zhan Zhu, Qian Dong, Lin Su
BACKGROUND: Hepatoblastoma (HB) is the most common malignant liver tumor in childhood. Complete HB surgical resection which is technically demanding is the cornerstone of effective therapy with a good prognosis. The aim of our study is to evaluate the usefulness of 3D simulation software in assisting hepatectomy in pediatric patients with HB. METHODS: 21 children with HB who underwent hepatectomy were enrolled in this study. All patients underwent computer tomography (CT) imaging preoperatively...
September 2016: Surgical Oncology
Nae-Fang Twu, Yu-Che Ou, Cheng-I Liao, Wei-Yang Chang, Lan-Yan Yang, Yun-Hsin Tang, Tze-Chien Chen, Chi-Hau Chen, Tze-Ho Chen, Lain-Shung Yeh, Shih-Tien Hsu, Yu-Chieh Chen, Cheng-Chang Chang, Ya-Min Cheng, Chia-Yen Huang, Fu-Shing Liu, Yue-Shan Lin, Sheng-Mou Hsiao, Yuan-Yee Kan, Chyong-Huey Lai
OBJECTIVE: We aimed to identify prognostic factors of early-stage cervical adenocarcinoma (AC) and adenosquamous carcinoma (ASC) treated with primary radical surgery, and to evaluate the impact of postoperative adjuvant therapy on outcome. METHODS: The clinical-pathological data of all patients (n = 1132) with stages I-II cervical AC/ASC treated with primary radical surgery at the member hospitals of the Taiwanese Gynecologic Oncology Group were retrospectively reviewed...
September 2016: Surgical Oncology
A E Slagter, D Ryder, B Chakrabarty, A Lamarca, R A Hubner, W Mansoor, D A O'Reilly, P E Fulford, H J Klümpen, J W Valle, M G McNamara
AIM: Surgery is the only modality of cure in patients diagnosed with neuroendocrine tumours (NETs). The aim of this study was to identify prognostic factors associated with disease relapse in patients with NETs treated by potentially-curative surgery. METHODS: Sequential patients registered in The Christie European NET Society (ENETS) Centre of Excellence, with grade (G)1 or G2 NETs who had undergone curative surgery (February 2002-June 2014) were included. Investigated prognostic factors for relapse were: age, gender, TNM stage, tumour-localisation, functionality, genetic predisposition, presence of multiple NETs, second malignancy, grade (Ki-67-based), presence of vascular and/or perineural invasion, necrosis, surgical margin (R0/R1), Eastern Cooperative Oncology Group performance status and Adult Comorbidity Evaluation co-morbidity score...
September 2016: Surgical Oncology
Varun Puvanesarajah, Andrea M Spiker, Brett A Shannon, Maureen Grundy, Adam S Levin, Carol D Morris
Primary musculoskeletal cancer and metastatic disease to bone in pregnant patients presents major treatment challenges. Although uncommon, musculoskeletal malignancies in pregnant women have been reported. When diagnosing and treating these patients, the mother's health must be managed appropriately while ensuring that fetal development is not deleteriously affected. Extensive radiographic imaging and more advanced techniques are often necessary to fully characterize the extent of disease. When possible, magnetic resonance imaging should be used instead of computed tomography to limit exposure of the conceptus to radiation...
September 2016: Surgical Oncology
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