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Surgical Oncology

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https://www.readbyqxmd.com/read/29113675/surgery-induced-tumor-growth-in-metastatic-colorectal-cancer
#1
REVIEW
Klaas M Govaert, Jennifer M J Jongen, Onno Kranenburg, Inne H M Borel Rinkes
Metastatic colorectal cancer (mCRC) is a devastating disease causing 700.000 deaths annually worldwide. Metastases most frequently develop in the liver. Partial hepatectomy has dramatically improved clinical outcome and is the only curative treatment option for eligible patients with mCRC. Pre-clinical studies have shown that surgical procedures can have tumor-promoting local 'side-effects' such as hypoxia and inflammation, thereby altering the behaviour of residual tumor cells. In addition, systemically released factors following (colon or liver) surgery can act as a wakeup-call for dormant tumor cells in distant organs and/or help establish a pre-metastatic niche...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113674/lncrna-zeb1-as1-predicts-unfavorable-prognosis-in-gastric-cancer
#2
Yanliang Li, Xiaowen Wen, Longgang Wang, Xianjun Sun, Heng Ma, Zheng Fu, Leping Li
OBJECTIVES: LncRNA ZEB1 Antisense 1 (ZEB1-AS1) has been suggested to be an oncogenic role in human hepatocellular carcinoma, osteosarcoma, glioma and esophageal carcinoma progression. However, the clinical significance and biological function of ZEB1-AS1 in gastric cancer is poorly understood. METHODS: Levels of ZEB1-AS1 expression in gastric cancer tissues and cell lines were detected by qRT-PCR. Loss-of-function and gain-of-function studies were conducted to explore the biological function of ZEB1-AS1 in gastric cancer cells migration, invasion and EMT process...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113673/esophageal-adenocarcinoma-stage-iii-survival-based-on-pathological-response-to-neoadjuvant-treatment
#3
Katrin Schwameis, Joerg Zehetner, Jeffrey A Hagen, Daniel S Oh, Stephanie G Worrell, Kais Rona, Nathan Cheng, Jamil Samaan, Kyle M Green, John C Lipham
BACKGROUND: Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced esophageal adenocarcinomas (EAC). Pathological response is thought to be a major prognostic factor. Aims of this study were to determine the frequency of complete response and to compare the survival of complete and incomplete responders in stage III EAC. METHODS: A retrospective review was performed of all stage III patients that underwent neoadjuvant therapy followed by esophagectomy between 1999 and 2015...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113672/vulvo-vaginal-reconstruction-after-radical-excision-for-treatment-of-vulvar-cancer-evaluation-of-feasibility-and-morbidity-of-different-surgical-techniques
#4
REVIEW
Violante Di Donato, Carlotta Bracchi, Emanuele Cigna, Lavinia Domenici, Angela Musella, Andrea Giannini, Francesca Lecce, Claudia Marchetti, Pierluigi Benedetti Panici
BACKGROUND: Vulvar cancer is a rare disease accounting for approximately 5% of female genital tract tumors worldwide. Currently surgery represents the mainstay alone or sometimes, in combination with chemo-radiotherapy, for locally advanced tumors and recurrent disease. However, significant physical and sexual impairment mostly due to anatomical distortion of external genitalia are a consequence of radical surgical treatment. Postoperative reconstruction after demolitive surgeries improves aesthetic and functional results, guarantees an adequate coverage of large tumors and assures safe surgical margin...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113671/predictors-of-venous-thromboembolism-in-patients-with-primary-sarcoma-of-bone
#5
Courtney L Kaiser, Micayla K Freehan, Daniel A Driscoll, Joseph H Schwab, Karen De Amorim Bernstein, Santiago A Lozano-Calderon
Venous thromboembolism (VTE) is known to be independently associated with both orthopaedic surgery and malignancy. Patients undergoing surgery for musculoskeletal malignancies are at an increased risk for thromboembolic events. Although VTE can lead to serious morbidity and mortality, the potential complications of prophylactic anticoagulation call for a greater understanding of a patient's risk factors, as well as more rigorous guidelines for prophylactic anticoagulation regimens. The aims of this study were to 1) Analyze the rate of VTE in patients surgically treated for primary bone sarcoma; 2) Identify risk factors for VTE in patients with primary bone sarcoma; 3) Discuss the complications associated with prophylactic anticoagulation in patients with primary bone sarcoma...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113670/primary-arthroplasty-in-healed-osteoarticular-allograft-in-patients-with-history-of-primary-femoral-bone-tumors
#6
Bianca M Verbeek, Courtney L Kaiser, Nuno Rui Paulino Pereira, Francis J Hornicek, Kevin A Raskin, Joseph H Schwab, Santiago A LozanoCalderón
BACKGROUND: Roughly 25-35% of patients who are treated with osteoarticular allograft for primary bone sarcomas or aggressive benign bone tumors require surgery in the long-term due to degenerative changes of the articular surface of the allograft. There are three established methods of reconstruction for this complication; a total hip arthroplasty (THA) or total knee arthroplasty (TKA) in the retained osteoarticular allograft, a proximal or distal endoprosthesis after removal of the allograft, and an allograft-prosthesis composite (APC)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113669/target-registration-error-minimization-involving-deformable-organs-using-elastic-body-splines-and-particle-swarm-optimization-approach
#7
Dominik Spinczyk, Sylwester Fabian
In minimally invasive surgery one of the main challenges is the precise location of the target during the intervention. The aim of the study is to present usability of elastic body splines (EBS) to minimize TRE error. The method to find the desired EBS parameters values is presented with usage of Particle Swarm optimization approach. This ability of TRE minimization has been achieved for the respiratory phases corresponding to minimum FRE for abdominal (especially liver) surgery. The proposed methodology was verified during experiments conducted on 21 patients diagnosed with liver tumors...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113668/preoperative-geriatric-nutritional-risk-index-a-predictive-and-prognostic-factor-in-patients-with-pathological-stage-i-non-small-cell-lung-cancer
#8
Fumihiro Shoji, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Gouji Toyokawa, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: Surgical outcomes of early-stage non-small cell lung cancer (NSCLC) are poor. The Geriatric Nutritional Risk Index (GNRI) is a useful parameter for evaluating nutritional status. We aimed to investigate if preoperative GNRI could be a predictive factor for pathological stage I NSCLC patients. PATIENTS AND METHODS: We retrospectively selected 141 consecutive pathological stage I NSCLC patients treated from August 2005 to August 2010. We analyzed their preoperative GNRI in univariate and multivariate Cox regression analyses for postoperative recurrence-free survival (RFS)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113667/abcb1-gene-polymorphisms-and-response-to-chemotherapy-in-breast-cancer-patients-a-meta-analysis
#9
Adela Madrid-Paredes, Marisa Cañadas-Garre, Antonio Sánchez-Pozo, Manuela Expósito-Ruiz, Miguel Ángel Calleja-Hernández
The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T, C1236T and G2677T/A), are the most widely studied in ABCB1. The inconsistent conclusions about the association of these polymorphisms and the response to chemotherapy in breast cancer (BC) patients prompted us to conduct a meta-analysis. A total of nine (770 patients), five (566 patients) and three studies (367 patients) relating the ABCB1 C3435T, C1236T and G2677T/A polymorphisms respectively, were included...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113666/predictive-biomarkers-for-response-of-esophageal-cancer-to-chemo-radio-therapy-a-systematic-review-and-meta-analysis
#10
REVIEW
Yang Li, He-Cheng Huang, Long-Qi Chen, Li-Yan Xu, En-Min Li, Jian-Jun Zhang
BACKGROUND: Esophageal cancer remains a major public health issue worldwide. In clinical practice, chemo(radio)therapy is an important approach to patients with esophageal cancer. Only the part of patients who respond to chemo(radio)therapy achieve better long-term outcome. In this case, predictive biomarkers for response of esophageal cancer patients treated with chemo(radio)therapy are of importance. Meta-analysis of P53 for predicting esophageal cancer response has been reported before and is not included in our study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113665/endoscopic-assessment-of-tumor-regression-after-preoperative-chemoradiotherapy-as-a-prognostic-marker-in-locally-advanced-rectal-cancer
#11
Dae Kyung Sohn, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Hee Jin Chang, Ji Yeon Baek, Min Ju Kim, Sung Chan Park, Jae Hwan Oh, Dae Yong Kim
PURPOSE: This study was designed to evaluate tumor regression endoscopic criteria for predicting the post-chemoradiotherapy (CRT) prognosis of patients with locally advanced rectal cancer. MATERIAL AND METHODS: A total of 425 patients with rectal cancer who received radical surgery after CRT were included in this study. All patients were divided into two groups according to post-CRT preoperative endoscopic findings: 1) good response (E-GR): scar, telangiectasia, or erythema; 2) minimal or no response (E-MR): nodules, ulcers, strictures, or remnant tumor...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113664/risk-prediction-model-for-major-complication-after-hepatectomy-for-malignant-tumour-a-validated-scoring-system-from-a-university-center
#12
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth S H Chok, Albert Chi Yan Chan, Wing Chiu Dai, Chung Mau Lo
OBJECTIVE: To derive and validate a scoring system for major complication after hepatectomy. BACKGROUND: Complications after hepatectomy significantly compromise survival outcomes, method to predict such risk is lacking. A reliable scoring system is therefore awaited. METHODS: Consecutive adult patients receiving hepatectomy for primary or secondary liver malignancy from 1995 to 2014 were recruited. After randomization, patients were allocated to derivation and validation group respectively...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113663/krukenberg-tumors-seed-route-and-soil
#13
REVIEW
Annamaria Agnes, Alberto Biondi, Riccardo Ricci, Valerio Gallotta, Domenico D'Ugo, Roberto Persiani
The aim of this narrative review was to summarize the current evidence on Krukenberg tumors (KTs), addressing what is known on their natural history and their impact on the clinical prognosis and which are the most appropriate management strategies to treat this condition. A literature search was conducted on Pubmed up to December 2016, selecting the most relevant studies on the basis of the scope of the review. KTs are ovarian metastases from primary signet-ring cell carcinomas., characterized by the presence of a sarcoma-like stroma...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113662/practice-variation-in-sentinel-lymph-node-biopsy-for-melanoma-patients-in-different-geographical-regions-in-the-netherlands
#14
J Verstijnen, S Damude, H J Hoekstra, S Kruijff, A J Ten Tije, W J Louwman, E Bastiaannet, M M Stuiver
BACKGROUND: Due to the lack of solid evidence for treatment benefit of Sentinel Lymph Node Biopsy (SLNB) as part of loco-regional surgical treatment of non-distant metastatic melanoma, there might be variation in surgical treatment strategies in the Netherlands. The objective of the current study was to assess differences in the performance of SLNB, in geographical regions in the Netherlands, of non-distant metastatic melanoma patients (American Joint Committee on Cancer (AJCC) stage I-III)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113661/program-death-1-immune-checkpoint-and-tumor-microenvironment-in-malignant-liver-tumors
#15
REVIEW
Demetrios Moris, Amir A Rahnemai-Azar, XuFeng Zhang, Ioannis Ntanasis-Stathopoulos, Diamantis I Tsilimigras, Jeffery Chakedis, Chrysoula Argyrou, John J Fung, Timothy M Pawlik
Hepatic malignancies are one of the leading causes of cancer death globally. Considering the limited efficacy of current standard treatments in management of patients with advanced liver cancers, there has been a growing interest in identifying novel therapies. Despite achieving promising results in initial clinical trials, the therapeutic benefit of immunotherapy is limited due to strong immune-tolerogenic characteristics of liver tumors. Therapeutic regimens that impede tumor immunosuppressive mechanisms or elaborate tumor-specific immunity may improve clinical outcomes of patients with liver malignancies...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113660/functional-hepatic-imaging-as-a-biomarker-of-primary-and-secondary-tumor-response-to-loco-regional-therapies
#16
REVIEW
H L Lewis, M A Ghasabeh, P Khoshpouri, I R Kamel, T M Pawlik
Objective criteria to measure tumor response are a key tenet for assessment of treatment efficacy when evaluating a therapeutic modality. Several response criteria have been proposed including the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), RECIST 1-1, and European Association for the Study of the Liver (EASL) guidelines. Response following loco-regional therapies (LRT) can be particularly difficult to assess as post-treatment changes may not always relate to changes in lesion size...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113659/a-comparative-study-of-neoadjuvant-treatment-with-gemcitabine-plus-nab-paclitaxel-versus-surgery-first-for-pancreatic-adenocarcinoma
#17
Benedetto Ielpo, Riccardo Caruso, Hipolito Duran, Eduardo Diaz, Isabel Fabra, Luis Malavé, Valentina Ferri, Rafael Alvarez, Antonio Cubillo, Carlos Plaza, Sara Lazzaro, Denis Kalivaci, Yolanda Quijano, Emilio Vicente
INTRODUCTION: Neoadjuvant treatment has been reported to prolong survival in patients with potentially resectable pancreatic adenocarcinoma (PA). However, there are currently limited clinical results available using nab-paclitaxel and gemcitabine in PA. This paper compares the oncological results of patients affected by potentially resectable PA who underwent surgery first (SF) versus surgery following neoadjuvant treatment (NAT). METHODS: This is an observational, comparative study whereby data were abstracted from a prospective database of patients affected by PA from 2007 to 2016...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113658/circulating-cell-free-dna-in-plasma-of-colorectal-cancer-patients-a-potential-biomarker-for-tumor-burden
#18
Jagdeep Singh Bhangu, Hossein Taghizadeh, Tamara Braunschmid, Thomas Bachleitner-Hofmann, Christine Mannhalter
BACKGROUND: Measurement of cell-free DNA (cfDNA) in plasma - the so called liquid biopsy - is a novel method for early detection of cancer. Necrotic cancer cells release various DNA fragments that can be detected in plasma or serum. The aim of our study was to investigate the concentration of circulating ALU115, LINE79 and LINE297 fragments in plasma from venous and arterial blood of colorectal cancer (CRC) patients before, during and 5 days after surgical intervention. PATIENTS AND METHODS: Thirty patients (16 female, 14 male, median age 56 years), undergoing surgery for colorectal and appendix cancer, and 17 healthy volunteers were included in this study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113657/huang-s-three-step-maneuver-shortens-the-learning-curve-of-laparoscopic-spleen-preserving-splenic-hilar-lymphadenectomy
#19
REVIEW
Chang-Ming Huang, Ze-Ning Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Lu Jun, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu
BACKGROUND: The goal of this study was to investigate the difference between the learning curves of different maneuvers in laparoscopic spleen-preserving splenic hilar lymphadenectomy for advanced upper gastric cancer. METHODS: From January 2010 to April 2014, 53 consecutive patients who underwent laparoscopic spleen-preserving splenic hilar lymphadenectomy via the traditional-step maneuver (group A) and 53 consecutive patients via Huang's three-step maneuver (group B) were retrospectively analyzed...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113656/introduction-of-the-resection-severity-index-as-independent-risk-factor-limiting-survival-after-resection-of-colorectal-liver-metastases
#20
Jill Gwiasda, Harald Schrem, Alexander Kaltenborn, Jan Mahlmann, Heiko Mix, Frank Lehner, Nicolas Kayser, Jürgen Klempnauer, Ulf Kulik
BACKGROUND: The purpose of this study is to evaluate the influence of the recently introduced resection severity index (RSI) in patients with liver resection for hepatocellular carcinoma on survival after resection of colorectal liver metastases. The RSI quantifies pre-operatively the liver cellular damage, liver synthetic function and loss of organ parenchyma. METHODS: All consecutive patients who underwent liver resection for metastases of colorectal cancer (CLM) between 2000 and 2015 were included in this study...
December 2017: Surgical Oncology
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