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Surgical Oncology

Vijay P Khatri, Miguel A Rodrigues-Bigas, Rob Flewell, Nicholas J Petrelli
No abstract text is available yet for this article.
June 2018: Surgical Oncology
Vijay P Khatri, Nicholas J Petrelli
No abstract text is available yet for this article.
June 2018: Surgical Oncology
Giulia Cossu, Louis-Marie Terrier, Lotfi Benboubker, Christophe Destrieux, Stéphane Velut, Patrick François, Ilyess Zemmoura, Aymeric Amelot
BACKGROUND: Patients with multiple myeloma (MM) have an extremely heterogeneous prognosis. The International Staging System (ISS) is actually the most reliable staging system and chromosomal abnormalities were integrated in the Revised-ISS. We wanted to evaluate the prognostic value of spinal secondary localization in patients with MM and its impact on the ISS. METHODS: Epidemiological and biological data, as well as treatment protocols and secondary localization were analyzed for 650 consecutive patients diagnosed with MM from January 2006 to January 2017...
June 2018: Surgical Oncology
Hui-Yu Chang, Yu-Kai Tseng, Yu-Chia Chen, Chih-Wen Shu, Miaw-I Lin, Huei-Han Liou, Ting-Ying Fu, Yun-Chung Lin, Luo-Ping Ger, Ming-Hsin Yeh, Pei-Feng Liu
BACKGROUND: High Snail expression is known as a poor prognostic factor in breast cancer. However, its prognostic impact for breast cancer with different molecular subtypes is still controversial. METHODS: Snail expression was examined by immunohistochemistry in tissue microarray slides of 85 corresponding tumor-adjacent normal (CTAN) and 247 breast invasive ductal carcinoma (IDC) tissues. Multivariable Cox regression analysis was used to assess the impact of Snail expression on survival rate by different molecular subtypes of breast IDC patients...
June 2018: Surgical Oncology
Ruanmin Zou, Xiangjian Chen, Xuejing Jin, Shi Li, Rongying Ou, Jisen Xue, Xiaojian Yan, Lulu Chen, Yan Hu, Hua Zhu
OBJECTIVES: Recently, thousands of long non-coding RNAs (lncRNAs) involved in development and metastasis of malignant tumors have been identified. Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) has been proved to promote proliferation and metastasis in multiple tumors. However, the function and significance of BCAR4 in cervical cancer are still unclear. METHODS: In this study, we concentrated on the biological function and clinical significance of BCAR4 in cervical cancer...
June 2018: Surgical Oncology
In-Seob Lee, Hyo Jeong Kang, Young-Soo Park, Min-Hee Ryu, Jeong-Hwan Yook, Yoon-Koo Kang, Byung-Sik Kim
BACKGROUND: In addition to the TNM stage, an additional prognostic factor is needed to assess the prognosis of gastric cancer. Moreover, there is no consensus on high-risk group of recurrence and adjuvant strategy in stage 1B gastric cancers. We aimed to investigate the prognostic significance of extranodal extension (ENE) in stage 1B gastric carcinomas and assess whether ENE can indicate the need for adjuvant treatment. METHODS: The clinicopathological characteristics of 1588 patients who underwent curative gastrectomy with more than D1 plus lymphadenectomy for stage 1B gastric cancer from 2003 to 2010 were reviewed...
June 2018: Surgical Oncology
Daniel Santa Mina, William J Hilton, Andrew G Matthew, Rashami Awasthi, Guillaume Bousquet-Dion, Shabbir M H Alibhai, Darren Au, Neil E Fleshner, Antonio Finelli, Hance Clarke, Armen Aprikian, Simon Tanguay, Franco Carli
INTRODUCTION: Preoperative exercise and fitness are predictors of surgical recovery; however, little is known of the effect of preoperative exercise-based conditioning, known as prehabilitation, in this for men undergoing radical prostatectomy. Our study examined the feasibility and effects of prehabilitation on perioperative and postoperative outcomes in men undergoing radical prostatectomy. METHODS: This feasibility RCT compared prehabilitation (PREHAB) versus a control condition (CON) in 86 men undergoing radical prostatectomy...
June 2018: Surgical Oncology
Diamantis I Tsilimigras, Ioannis Ntanasis-Stathopoulos, Fabio Bagante, Demetrios Moris, Jordan Cloyd, Eleftherios Spartalis, Timothy M Pawlik
BACKGROUND: Hepatic resection is considered the optimal potentially curative treatment for colorectal liver metastases (CRLM). Following resection, up to two-thirds of patients will develop recurrence within 5-years. Genetic mutation analysis of CRLM, especially KRAS status, has been proposed as a means to guide treatment, as well as identifying patients who can derive the most survival benefit from hepatic resection. METHODS: A systematic review of the literature was conducted the PubMed, Embase and Cochrane library through February 8th, 2018...
June 2018: Surgical Oncology
D Badrudin, L Sideris, F A Leblond, V Pichette, A S Cloutier, P Drolet, P Dubé
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin (OX) is the standard of care for selected patients with peritoneal carcinomatosis of colorectal origin. Because 5-FU is mandatory to improve efficacy of OX when used by systemic route, several teams now empirically combine intravenous (IV) 5-FU with HIPEC OX, but this practice has yet to be supported by preclinical data. Using a murine model, we studied the impact of IV 5-FU on peritoneal absorption of HIPEC OX...
June 2018: Surgical Oncology
Caroline Eden, Gary Esses, Daniel Katz, Samuel DeMaria
This narrative review will summarize our current understanding of the effects of perioperative interventions on patients undergoing surgical removal of breast malignancies. It will focus on how different anesthetic agents and perioperative interventions might affect both breast cancer behavior and/or tumor recurrence as well as postoperative recovery. The main objective of this study will be to describe the evidence and critically analyze preclinical and clinical studies on the use of intravenous versus inhaled anesthetic agents, opioids, regional anesthetics, and anesthetic adjuncts in patients undergoing breast cancer resection...
June 2018: Surgical Oncology
Satoru Okada, Kyoko Itoh, Shunta Ishihara, Junichi Shimada, Daishiro Kato, Hiroaki Tsunezuka, Naoko Miyata, Shigeru Hirano, Satoshi Teramukai, Masayoshi Inoue
BACKGROUND: The mechanism by which tumors escape the immune system has been actively investigated and is partly explained by the programmed death-1 (PD-1) and its ligand (PD-L1) pathway. This study is aimed at clarifying the prognostic significance of PD-L1 expression in patients with surgically resected pulmonary metastases of head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: A retrospective review was conducted of 26 HNSCC patients who underwent complete resection of pulmonary metastases...
June 2018: Surgical Oncology
G S Kireeva, G I Gafton, K D Guseynov, K Y Senchik, O A Belyaeva, V G Bespalov, A V Panchenko, M A Maydin, A M Belyaev
A systematic review of the studies where HIPEC combined with cytoreductive surgery was used in patients with primary advanced ovarian cancer was performed to understand is there a role for this treatment modality not only in recurrent but in primary advanced ovarian cancer. The results are controversial but there is a strong trend for improvement of the long-term outcomes of patients with primary advanced ovarian cancer after HIPEC.
June 2018: Surgical Oncology
Davendra P S Sohal, Katherine Tullio, Alok A Khorana
INTRODUCTION: Evidence supporting adjuvant therapy for resected pancreatic cancer is limited primarily to head tumors. We analyzed data from the National Cancer Database (NCDB) to evaluate the relationship of tumor site with benefit from adjunctive (adjuvant, neoadjuvant, perioperative) therapy (Rx). METHODS: All NCDB patients with clinical stage I and II pancreatic cancer, diagnosed from 2003 to 2013, who underwent surgical resection and had data on site of primary were included...
June 2018: Surgical Oncology
Pierangelo Marchiolè, Domenico Ferraioli, Eva Moran, Serafina Mammoliti, Jean-Dominique Tigaud, Frédéric Beurrier, Nicolas Chopin, Patrice Mathevet
No abstract text is available yet for this article.
June 2018: Surgical Oncology
Nunzia Cinzia Paladino, Carole Guérin, Aoïfe Lowery, Andrea Attard, Wassim Essamet, Eveline Slotema, Isabelle Morange, Frédéric Castinetti, Thierry Brue, Anderson Loundou, David Taïeb, Frédéric Sebag
BACKGROUND: adrenal tumor-to-liver uptake value (Tmx:Lmx) on 18 F-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses. The potential impact of steroid hormone secretion on 18 F-FDG uptake is still debatable. The aim of this study was to evaluate this relationship. METHODS: 2010-2015: 73 patients who underwent adrenalectomy for adrenocortical tumors [49 secreting/(SA) and 24 non-secreting/(NSA)] were retrospectively included in the study...
June 2018: Surgical Oncology
Andrew C Prince, Lindsay S Moore, Kiranya E Tipirneni, Tushar Ramesh, Mihir A Limdi, Stephanie L Bevans, Erika M Walsh, Benjamin Greene, Eben L Rosenthal, Jason M Warram
BACKGROUND: Tumor proliferation often occurs from pathologic receptor upregulation. These receptors provide unique targets for near-infrared (NIR) probes that have fluorescence-guided surgery (FGS) applications. We demonstrate the use of three smart-targeted probes in a model of head and neck squamous cell carcinoma. METHODS: A dose escalation study was performed using IntegriSense750, ProSense750EX, and ProSense750FAST in mice (n = 5) bearing luciferase-positive SCC-1 flank xenograft tumors...
June 2018: Surgical Oncology
Sung Il Kang, Heung-Kwon Oh, Jae Suk Yoo, Soyeon Ahn, Min Hyun Kim, Myung Jo Kim, Il Tae Son, Duck-Woo Kim, Sung-Bum Kang, Young Soo Park, Chang Jin Yoon, Rumi Shin, Seung Chul Heo, In Taek Lee, Eui Gon Youk, Min Jung Kim, Tae Young Chang, Sung-Chan Park, Dae Kyung Sohn, Jae Hwan Oh, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
BACKGROUND: Colonic self-expanding metallic stenting (SEMS) is widely used for the treatment of malignant colonic obstruction as a bridge to elective surgery. However, the effects of colonic stenting on long-term oncologic outcomes are debatable. This study aimed to compare the long-term oncologic outcomes of preoperative SEMS insertion with those of immediate surgery in patients with obstructing left-sided colorectal cancer. METHODS: A cohort of consecutive patients who underwent radical surgery for obstructing left-sided colorectal cancer between 2004 and 2011 in five tertiary referral hospitals were analyzed...
June 2018: Surgical Oncology
Sara Kehlet Watt, Hans Carl Hasselbalch, Vibe Skov, Lasse Kjær, Mads Thomassen, Torben A Kruse, Mark Burton, Ismail Gögenur
INTRODUCTION: Cancer surgery may represent a potential risk of enhanced growth and metastatic ability of residual cancer cells due to post-operative immune dysfunction. This study identifies changes in transcription of genes involved in immune surveillance, immune suppression and carcinogenesis in the post-operative period of laparoscopic colon-cancer surgery within an ERAS regime. METHODS: Patients undergoing elective, curatively intended laparoscopic surgery for colon cancer stage I-III UICC were included in the study...
June 2018: Surgical Oncology
Giovanni Dell'Aversana Orabona, Vincenzo Abbate, Fabio Maglitto, Paola Bonavolontà, Giovanni Salzano, Antonio Romano, Alfonso Reccia, Umberto Committeri, Giorgio Iaconetta, Luigi Califano
Facial symmetry, as well as function, remains the big challenge for surgeons who attempt mandibular reconstruction. Nowadays several studies recommend the use of computer aided surgery (CAS) and CAD/CAM technology to guide mandibular segmental osteotomies and reconstruction using free fibula flap. Although these systems have radically changed the way of doing mandibular reconstructive surgery, they are expensive and require extended periods of time for prototypation. This may be an important limitation in case of malignant neoplasms which require short-term treatment...
June 2018: Surgical Oncology
M J Wilson, J W T Dekker, S Buettner, J J Harlaar, J Jeekel, M Schipperus, J J Zwaginga
INTRODUCTION: Intravenous iron therapy has been shown to be advantageous in treating anaemia and reducing the need for blood transfusions. Iron treatment, however, may also be hazardous by supporting cancer growth. Present clinical study explores, for the first time, the effect of preoperative intravenous iron therapy on tumour prognosis in anaemic colorectal cancer patients. METHODS: A retrospective cohort study was performed on consecutive patients who underwent surgery for colorectal cancer between 2010 and 2016 in a single teaching hospital...
June 2018: Surgical Oncology
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