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https://www.readbyqxmd.com/read/30407277/mitochondrial-pathway-is-involved-in-advanced-glycation-end-products-induced-apoptosis-of-rabbit-annulus-fibrosus-cells
#1
Yiqiang Hu, Zengwu Shao, Xianyi Cai, Yunlu Liu, Min Shen, Yingtao Yao, Tian Yuan, Wentian Wang, Fan Ding, Liming Xiong
STUDY DESIGN: Experimental study. OBJECTIVE: The purposes of this study were to evaluate whether advanced glycation end-products (AGEs) induce annulus fibrosus (AF) cell apoptosis and further to explore the mechanism by which this process occurs. SUMMARY OF BACKGROUND DATA: Recent studies revealed that AGEs accumulation is considered an important factor in diabetic intervertebral disc (IVD) degeneration. However, the effect of AGEs on intervertebral disc remains unclear...
November 6, 2018: Spine
https://www.readbyqxmd.com/read/30395095/treatment-for-frailty-does-not-improve-complication-rates-in-corrective-surgery-for-adult-spinal-deformity
#2
Mitsuru Yagi, Takehiro Michikawa, Naobumi Hosogane, Nobuyuki Fujita, Eijiro Okada, Satoshi Suzuki, Osahiko Tsuji, Narihito Nagoshi, Takashi Asazuma, Takashi Tsuji, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
STUDY DESIGN: A retrospective multicenter database review of 240 consecutive patients at least 21 years of age (mean 58 ± 17, range 22-79) who underwent surgery for ASD and were followed at least 2 years. OBJECTIVE: To investigate how treatment for frailty affects complications in surgery for ASD. SUMMARY OF BACKGROUND: Several recent studies have focused on associations between frailty and surgical complications. However, it is not clear whether treating frailty affects complication rates in surgery for adult spinal deformity (ASD)...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395094/a-morphometric-study-on-subaxial-cervical-pedicles-of-thai-people
#3
Jarupon Mahiphot, Sitthichai Iamsaard, Tarinee Sawatpanich, Surachai Sae-Jung, Kimaporn Khamanarong
STUDY DESIGN: This study investigated the subaxial cervical pedicles from C3 to C7 to provide information for accurately transpedicular screw fixation in this region. OBJECTIVE: This study was evaluated the morphology of the subaxial cervical pedicle to determine the size and trajectory of screw fixation. SUMMARY OF BACKGROUND DATA: Cervical vertebrae are an important structure to protect the neurovascular structure. The cervical spine surgery using screw fixation is an effective method to treat the cervical spine instability...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395093/minimum-clinically-important-difference-and-patient-acceptable-symptom-state-of-japanese-orthopaedic-association-score-in-degenerative-cervical-myelopathy-patients
#4
So Kato, Yasushi Oshima, Yoshitaka Matsubayashi, Yuki Taniguchi, Sakae Tanaka, Katsushi Takeshita
STUDY DESIGN: A retrospective analysis. OBJECTIVE: To elucidate the psychometric properties of the original Japanese Orthopaedic Association (JOA) score, including the minimum detectable change (MDC), minimum clinically important difference (MCID) and patient accepted symptom state (PASS). SUMMARY OF BACKGROUND DATA: Despite the worldwide popularity of modified JOA score, the original JOA score is still commonly used in East Asian countries, including Japan...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395092/the-changing-position-of-the-center-of-mass-of-the-thorax-during-growth-in-relation-to-pre-existent-vertebral-rotation
#5
Steven de Reuver, Rob C Brink, Jelle F Homans, Moyo C Kruyt, Marijn van Stralen, Tom P C Schlösser, René M Castelein
STUDY DESIGN: Cross-sectional. OBJECTIVE: To analyze the thoracic center of mass (COM) position of children at different ages and evaluate its relation with the previously reported pre-existent rotational pattern of the normal spine. SUMMARY OF BACKGROUND DATA: The normal, non-scoliotic thoracic spine is known to have a rotational pattern that changes direction during growth; a transition from left-sided towards right-sided rotation with increasing age...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395091/the-importance-of-the-pedicle-diameters-at-the-proximal-thoracic-vertebrae-for-the-correction-of-proximal-thoracic-curve-in-asian-patients-with-idiopathic-scoliosis
#6
Choon Sung Lee, Jae Hwan Cho, Chang Ju Hwang, Dong-Ho Lee, Jae-Woo Park, Kun-Bo Park
STUDY DESIGN: A retrospective comparative radiographic study OBJECTIVE.: The purpose of this study was to evaluate differences in the pedicle diameters of proximal thoracic vertebrae in relation to the severity of the proximal thoracic curve in Asian patients with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: A small pedicle diameter at the proximal thoracic vertebra has been reported in normal population but the changes of pedicle diameter in patients with a proximal thoracic curve have not been properly evaluated...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395090/predictors-of-extended-length-of-hospital-stay-in-adolescent-idiopathic-scoliosis-patients-undergoing-posterior-segmental-instrumented-fusion-an-analysis-of-407-surgeries-performed-at-a-large-academic-center
#7
Assem A Sultan, Ryan J Berger, William A Cantrell, Linsen T Samuel, Deepak Ramanathan, Jessica Churchill, Anas A Minkara, Joshua Golubovsky, Salam Bachour, Selena Pasadyn, Jaret M Karnuta, Pierre Tamer, Thomas E Kuivila, David P Gurd, Ryan C Goodwin
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The aims of this study were to (1) compare patient and procedure-specific characteristics among those who had short versus long hospital stays and (2) identify independent risk factors that may correlate with extended length of hospital stay (LOS) in patients with adolescent idiopathic scoliosis (AIS) who underwent posterior segmental instrumented fusion (PSIF). SUMMARY OF BACKGROUND DATA: Reducing the LOS and identifying risk factors associated with extended admission have become increasingly relevant to healthcare policy makers...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395089/an-insight-into-the-health-related-quality-of-life-of-adolescent-idiopathic-scoliosis-patients-undergoing-bracing-observation-and-previously-braced
#8
Prudence Wing Hang Cheung, Carlos King Ho Wong, Jason Pui Yin Cheung
STUDY DESIGN: Prospective cross-sectional study. OBJECTIVE: To determine the health-related quality of life (HRQoL) of adolescent idiopathic scoliosis (AIS) patients undergoing bracing, previously braced and observation only. SUMMARY OF BACKGROUND DATA: HRQoL is an important treatment outcome measure for AIS. A poor HRQoL may also negatively influence the success of bracing by reducing the likelihood of good brace compliance. Yet, the HRQoL thresholds for patients undergoing observation only, brace treatment or previous brace treatment is not well understood...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395088/bone-graft-substitutes-in-single-or-double-level-anterior-cervical-discectomy-and-fusion-a-systematic-review
#9
Jessica R Stark, Joseph Hsieh, Dorothy Waller
STUDY DESIGN: Systematic Review OBJECTIVE.: To undertake a systematic review of published literature to evaluate efficacy of bone graft substitutes on radiographic and clinical outcomes in single or double level anterior cervical discectomy and fusion (ACDF) for degenerative disease. SUMMARY OF BACKGROUND DATA: Anterior cervical discectomy and fusion (ACDF) is one of the most common spinal surgeries completed in the United States. Today bone graft substitutes including ceramic-based synthetic bone grafts, allografts, bone morphogenetic proteins, mesenchymal stem cells, and bone marrow aspirate are widely used to enhance fusions; even though the efficacy of these substitutes is poorly defined...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395087/longer-preoperative-duration-of-symptoms-negatively-affects-health-related-quality-of-life-after-surgery-for-cervical-radiculopathy
#10
Daniel Tarazona, Barrett Boody, Alan S Hilibrand, Justin Stull, Kerri Bell, Taolin Fang, Dhruv Goyal, Matthew Galetta, David Kaye, Christopher K Kepler, Mark F Kurd, Barrett I Woods, Kris E Radcliff, Jeffery A Rihn, D Greg Anderson, Alexander R Vaccaro, Gregory D Schroeder
STUDY DESIGN: Retrospective Cohort OBJECTIVE.: Determine the effect of duration of symptoms (DOS) on health-related quality of life (HRQOL) outcomes for patients with cervical radiculopathy. SUMMARY OF BACKGROUND DATA: The effect of DOS has not been extensively evaluated for cervical radiculopathy. METHODS: A retrospective analysis of patients who underwent an anterior cervical decompression and fusion for radiculopathy was performed. Patients were grouped based on DOS of less than 6 months, 6 months to 2 years, and more than 2 years and HRQOL outcomes were evaluated...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395086/epidemiology-of-spinal-fractures-in-a-level-one-trauma-center-in-the-netherlands-a-10-years-review
#11
Lars P den Ouden, Arjen J Smits, Agnita Stadhouder, Ricardo Feller, Jaap Deunk, Frank W Bloemers
STUDY DESIGN: Retrospective epidemiological study OBJECTIVE.: To describe the epidemiology of spinal fractures over a ten years period in a Level 1 Trauma center in the Netherlands. SUMMARY OF BACKGROUND DATA: Spinal fractures may have large socioeconomic consequences. The prevalence and outcomes likely change over the years due to improved traffic safety, increasing population age and improved medical treatment. This is the first study to address the epidemiology of spinal fractures over a large time period in the Netherlands...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395085/surgical-and-health-related-quality-of-life-outcomes-of-growing-rod-graduates-with-severe-versus-moderate-early-onset-scoliosis
#12
Ilkka J Helenius, Paul D Sponseller, Anna McClung, Jeff B Pawelek, Muharrem Yazici, John B Emans, George H Thompson, Charles E Johnston, Suken A Shah, Behrooz A Akbarnia
STUDY DESIGN: A retrospective review of a prospective, multicenter database. OBJECTIVE: The aim of this study was to compare surgical and quality-of-life outcomes at the end of growing rod treatment in patients with severe versus moderate early-onset scoliosis (EOS). SUMMARY OF BACKGROUND DATA: Knowledge of the outcomes of severe EOS after growth-friendly treatment is limited because this condition is uncommon. METHODS: We identified 40 children with severe EOS (major curve ≥90°) treated with growing rods before age 10 with minimum 2-year follow-up after last lengthening or final fusion...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395084/effect-of-prosthesis-width-and-depth-on-heterotopic-ossification-after-cervical-disc-arthroplasty
#13
Junfeng Zeng, Hao Liu, Hua Chen, Xin Rong, Yang Meng, Yi Yang, Yuxiao Deng, Chen Ding
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To investigate the effect of width and depth of the inserted cervical disc prosthesis on heterotopic ossification (HO) after cervical disc arthroplasty (CDA), and to explore the relationship between clinical outcome and HO. SUMMARY OF BACKGROUND DATA: The mechanism of HO formation still remains unknown. Footprint mismatch of cervical disc prosthesis was common in cervical arthroplasty. Compared with endplate, some inserted prostheses were smaller in width and length...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30395083/discrepancies-between-patient-and-surgeon-expectations-of-surgery-for-sciatica-a-challenge-for-informed-decision-making
#14
Yasir Rehman, Syed Muzammil, Wojtek Wiercioch, Nadia Rehman, Brian Drew, Aleska Cenic, Kesava Reddy, Naresh Murty, Edward Kucher, R Brett Dunlop, Gordon H Guyatt, Jason W Busse, Lisa Schwartz, Meredith Vanstone
STUDY DESIGN: Qualitative study. OBJECTIVE: The objective of this study was to compare the perceptions of patients and surgeons regarding the risks and benefits of lumbar decompressive surgery for sciatica following a consultation meeting. SUMMARY OF BACKGROUND DATA: Evidence regarding pain improvement in patients following lumbar decompressive surgery for sciatica is inconsistent. Given this inconsistency, patients choosing to undergo lumbar decompressive surgery must accept the risks associated with the surgery despite uncertainty regarding benefits...
November 1, 2018: Spine
https://www.readbyqxmd.com/read/30365415/spinal-cord-stimulators-a-comparison-of-the-trial-period-versus-permanent-outcomes
#15
Ajith Malige, Gbolabo Sokunbi
STUDY DESIGN: Retrospective chart review OBJECTIVE.: To address and characterize the differences between pain relief obtained from the "trial" versus permanent stimulator in the acute post-operative period (less than 6 weeks). SUMMARY OF BACKGROUND DATA: After a short stimulator trial (typically less than 7 days), patients who report at least a 50% relief are set up for permanent spinal cord stimulator (SCS) placement. The literature has shown that a subset of patients develop tolerance to these stimulating therapies, often resulting in reduced efficacy of symptom relief as early as two years post-permanent implantation...
October 25, 2018: Spine
https://www.readbyqxmd.com/read/30363014/optimizing-the-volume-value-relationship-in-laminectomy-an-evidence-based-analysis-of-outcomes-and-economies-of-scale
#16
William C Frankel, Sergio M Navarro, Heather S Haeberle, Deepak Ramanathan, Prem N Ramkumar
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: The objective of the present study was to establish evidence-based volume thresholds for surgeons and hospitals predictive of enhanced value in the setting of laminectomy. SUMMARY OF BACKGROUND DATA: Previous studies have attempted to characterize the relationship between volume and value, however, none to the authors' knowledge have employed an evidence-based approach to identify thresholds yielding enhanced value...
October 22, 2018: Spine
https://www.readbyqxmd.com/read/30325889/spinal-manipulative-therapy-effects-in-autonomic-regulation-and-exercise-performance-in-recreational-healthy-athletes-a-randomized-controlled-trial
#17
Pedro L Valenzuela, Sara Pancorbo, Alejandro Lucia, Francisco Germain
STUDY DESIGN: Randomized, double blind, parallel groups, sham-controlled trial. OBJECTIVE: To analyse the acute effects of spinal manipulative therapy (SMT) on performance and autonomic modulation. SUMMARY OF BACKGROUND DATA: The use of SMT is progressively spreading from the clinical to the sporting context owing to its purported ergogenic effects. However, its effects remain unclear. METHODS: . 37 male recreational athletes (aged 37 ± 9 years) who had never received SMT were assigned to a sham (n = 19) or actual SMT group (n = 18)...
October 15, 2018: Spine
https://www.readbyqxmd.com/read/30325888/10-year-outcomes-of-cervical-disc-replacement-with-the-bryan%C3%A2-cervical-disc-results-from-a-prospective-randomized-controlled-clinical-trial
#18
William F Lavelle, K Daniel Riew, Allan Levi, Jeffrey E Florman
STUDY DESIGN: Prospective, randomized multicenter IDE Trial between May 2002 and October 2004. OBJECTIVE: Report on the 10-year safety and efficacy of BRYAN® cervical disc (CDA). SUMMARY OF BACKGROUND DATA: Cervical disc arthroplasty (CDA) is a potential alternative for anterior cervical decompression and fusion (ACDF) with the hope that maintenance of motion may decrease the likelihood of adjacent segment disease. METHODS: This is an analysis of a FDA investigation comparing CDA with ACDF for single level patients...
October 15, 2018: Spine
https://www.readbyqxmd.com/read/30325887/design-and-implementation-of-an-enhanced-recovery-after-surgery-eras-program-for-minimally-invasive-lumbar-decompression-spine-surgery-initial-experience
#19
Ellen M Soffin, Avani S Vaishnav, Douglas Wetmore, Lauren Barber, Patrick Hill, Catherine Himo Gang, James D Beckman, Todd J Albert, Sheeraz A Qureshi
STUDY DESIGN: A retrospective cohort study of prospectively-collected data. OBJECTIVE: To describe the development of and early experience with an evidence-based ERAS pathway for lumbar decompression. SUMMARY OF BACKGROUND DATA: Enhanced recovery after surgery (ERAS) protocols have been consistently associated with improved patient experience and outcomes, and reduced cost and length of hospital stay (LoS). Despite successes in other orthopedic subspecialties, ERAS has yet to be established in spine surgery...
October 15, 2018: Spine
https://www.readbyqxmd.com/read/30325886/reliability-and-validity-of-the-turkish-version-of-the-fremantle-back-awareness-questionnaire
#20
Erkan Erol, Ayse Yildiz, Ramazan Yildiz, Umut Apaydin, Derya Gokmen, Bulent Elbasan
STUDY DESIGN: .: Cross-cultural adaptation, and psychometric analysis OBJECTIVE..: To develop the Turkish version of the Fremantle Back Awareness Questionnaire (FreBAQ-T) and to evaluate its psychometric properties. SUMMARY OF BACKGROUND DATA: .: There is a growing interest in the role that, the disturbance of body perception may lead long lasting pain problems such as chronic low back pain (CLBP). The Fremantle Back Awareness Questionnaire (FreBAQ), is a simple and low cost way of evaluating disturbed back awareness in people with CLBP...
October 15, 2018: Spine
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