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https://www.readbyqxmd.com/read/28727610/the-metabolopathy-of-tissue-injury-hemorrhagic-shock-and-resuscitation-in-a-rat-model
#1
Anne L Slaughter, Geoffrey R Nunns, Angelo D'Alessandro, Anirban Banerjee, Kirk C Hansen, E E Moore, Christopher C Silliman, Travis Nemkov, Hunter B Moore, Miguel Fragoso, Kiara Leasia, Erik D Peltz
INTRODUCTION: The metabolic consequences of trauma induce significant clinical pathology. In this study we evaluate the independent, metabolic contributions of tissue injury (TI) and combined tissue injury and hemorrhagic shock (TI / HS) using MS-metabolomics in a controlled animal model of critical injury. METHODS: Sprague-Dawley rats (n = 14) underwent TI alone or TI / HS, followed by resuscitation with normal saline and shed blood. Plasma was collected (baseline, post-laparotomy, post-HS, post-resuscitation) for Ultra High Pressure Liquid Chromatography (UHPLC) MS-metabolomics...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28727609/atrial-natriuretic-peptide-a-potential-early-therapy-for-the-prevention-of-multiple-organ-dysfunction-syndrome-following-severe-trauma
#2
Rong-Wei Zhang, Li-Li Liu, Lan-Lan Zeng, Rui-Jie Li, Ye-Hua Shen, Bin Zhang, Zi-Zhuo Liu, Meng-Fei Chen, Sheng-Mao Jiang, Li-Bing Jiang, Xiao-Gang Zhao, Shou-Yin Jiang
Trauma remains a tremendous medical burden partly because of increased expenditure for the management of multiple organ dysfunction syndrome (MODS) developed during hospital stay. The intestinal barrier injury continues to be a second insult resulting in MODS which currently lacks efficient strategies for prevention. Recent studies have uncovered multi-organ protective benefits of atrial natriuretic peptide (ANP) in cardiovascular disease. However, the role of ANP in prevention of MODS following severe trauma has not been understood...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28727608/evaluation-of-non-invasive-hemoglobin-monitoring-in-trauma-patients-with-low-hemoglobin-levels
#3
Medhat Gamal, Bassant Abdelhamid, Dina Zakaria, Omnia Abd El Dayem, Ashraf Rady, Maher Fawzy, Ahmed Hasanin
OBJECTIVE: Bleeding is a leading cause of death among trauma patients. Delayed assessment of blood hemoglobin level might result in either unnecessary blood transfusion in non-indicated patients or delayed blood transfusion in critically bleeding patients. In this study, we evaluate the precision of non-invasive hemoglobin monitoring in trauma patients with low hemoglobin levels. METHODS: We included trauma patients with low hemoglobin levels (less than 8 g/dL) scheduled for surgical intervention...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28727607/new-onset-heart-failure-and-mortality-in-hospital-survivors-of-sepsis-related-left-ventricular-dysfunction
#4
Saraschandra Vallabhajosyula, Jacob C Jentzer, Jeffrey B Geske, Mukesh Kumar, Ankit Sakhuja, Akhil Singhal, Joseph T Poterucha, Kianoush Kashani, Joseph G Murphy, Ognjen Gajic, Rahul Kashyap
BACKGROUND: The association between new-onset left ventricular (LV) dysfunction during sepsis with long-term heart failure outcomes is lesser understood. METHODS: Retrospective cohort study of all adult patients with severe sepsis and septic shock between 2007 and 2014 that underwent echocardiography within 72 hours admitted to the intensive care unit. Patients with prior heart failure, LV dysfunction, and structural heart disease were excluded. LV systolic dysfunction was defined as LV ejection fraction <50% and LV diastolic dysfunction as ≥grade II...
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28727606/the-clinical-utility-of-respiratory-variation-in-inferior-vena-cava-diameter-for-predicting-fluid-responsiveness-in-spontaneously-ventilating-patients
#5
Elliot Long, Ed Oakley, Trevor Duke, Franz E Babl
No abstract text is available yet for this article.
July 19, 2017: Shock
https://www.readbyqxmd.com/read/28719490/identification-of-hypotensive-emergency-department-patients-with-cardiogenic-etiologies
#6
Daniel J Henning, Kathleen E Kearney, M Kennedy Hall, Claudius Mahr, Nathan I Shapiro, Graham Nichol
OBJECTIVE: Identify predictors of cardiogenic etiology among Emergency Department (ED) patients with hypotension, and use these predictors to create a clinical tool to discern cardiogenic etiology of hypotension. METHODS: This secondary analysis evaluated a prospective cohort of consecutive patients with hypotension in an urban, academic, tertiary care ED from November 2012 to September 2013. We included adults with hypotension, defined as a new vasopressor requirement, systolic blood pressure (SBP) < 90 mmHg after at least 1L of crystalloid or 2 units packed red blood cells, or SBP < 90 mmHg and fluids withheld due to concern for fluid overload...
July 17, 2017: Shock
https://www.readbyqxmd.com/read/28719489/antithrombin-iii-attenuates-aki-following-acute-severe-pancreatitis
#7
Yiwei Kong, Jianyong Yin, Dongsheng Cheng, Zeyuan Lu, Niansong Wang, Feng Wang, Mingyu Liang
BACKGROUND: Antithrombin III (ATIII), the predominant coagulation factor inhibitor, possesses anti-inflammatory properties and exerts reno-protective effects on renal ischemia-reperfusion injury in animal models. However, the ATIII's protective effects of ATIII on acute kidney injury (AKI) following severe acute pancreatitis (SAP) need to be confirmed. METHODS: We assessed the association between ATIII activities and the incidence of AKI in patients with SAP, and explored therapeutic effects and potential mechanisms of ATIII on kidney injury in sodium taurocholate induced SAP rat model...
July 17, 2017: Shock
https://www.readbyqxmd.com/read/28697004/experimental-models-of-endotheliopathy-impact-of-shock-severity
#8
Nikolaus Hofmann, Johannes Zipperle, Mohammad Jafarmadar, Mostafa Ashmwe, Claudia Keibl, Carina Penzenstadler, Martin Ponschab, Behnaz Jafarmadar, Heinz Redl, Soheyl Bahrami, Herbert Schöchl
BACKGROUND: Hemorrhagic shock (HS) followed by resuscitation is often associated with sympatho-adrenal activation (SAA) and endothelial damage (ED). OBJECTIVE: We aimed to a) evaluate the impact of HS alone on the magnitude of SAA and consecutive ED and b) characterize potential targets for a standardized and reproducible model of HS-induced endotheliopathy in rats. METHODS: Rats were subjected to either a volume controlled HS (40% of total blood volume: v-HS group) or to a lab guided HS (l-HS) targeting base deficit (BD) >5...
July 10, 2017: Shock
https://www.readbyqxmd.com/read/28682946/cerebral-alterations-following-experimental-multiple-trauma-and-hemorrhagic-shock
#9
Nina Vogt, Christiane Herden, Elke Roeb, Martin Roderfeld, Daphne Eschbach, Thorsten Steinfeldt, Hinnerk Wulf, Steffen Ruchholtz, Eberhard Uhl, Karsten Schöller
Multiple trauma (MT) associated with hemorrhagic shock (HS) might lead to cerebral hypoperfusion and brain damage. We investigated cerebral alterations using a new porcine MT/HS model without traumatic brain injury (TBI) and assessed the neuroprotective properties of mild therapeutic hypothermia. Male pigs underwent standardized MT with HS (45% or 50% loss of blood volume) and resuscitation after 90/120 minutes (T90/T120). In additional groups (TH90/TH120) mild hypothermia (33°C) was induced following resuscitation...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682945/chronic-critical-illness-and-persistent-inflammation-what-can-we-learn-from-the-elderly-injured-septic-and-malnourished
#10
Vanessa Nomellini, Lewis J Kaplan, Carrie A Sims, Charles C Caldwell
Patients in the intensive care unit (ICU) who develop chronic critical illness significantly stress the clinical capacity and financial resources of healthcare systems. Although vast improvements have been made in critical care management, outcomes for this ICU subset remains poor. A hallmark for patients who progress to chronic critical illness is the development of persistent inflammation and immunosuppression. The risk factors associated with the development of chronic critical illness include increased age, medical comorbidities, severe injury, septic shock, and malnutrition...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682944/a-simplified-mortality-score-using-delta-neutrophil-index-and-the-thrombotic-microangiopathy-score-for-prognostication-in-critically-ill-patients
#11
Eun Kyong Goag, Jong Wook Lee, Yun Ho Roh, Ah Young Leem, Song Yee Kim, Joo Han Song, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung
BACKGROUND: This study was conducted to assess the prognostic value of a simplified mortality score (SMS) using the delta neutrophil index (DNI) and thrombotic microangiopathy (TMA) score, both easily obtained from the complete blood count, to identify critically ill patients at high risk of death. METHODS: This was a retrospective study performed in the medical ICU at Yonsei University College of Medicine from June 2015 to February 2016. The primary end-point was 28-day all-cause mortality...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682943/remote-ischemic-post-conditioning-improves-myocardial-dysfunction-via-the-risk-and-safe-pathways-in-a-rat-model-of-severe-hemorrhagic-shock
#12
Jianrong Huang, Dawei Xu, Qinyue Guo, Bing Ou, Qin Ling, Jianhua Li, Zhengfei Yang, Wanchun Tang
INTRODUCTION: Patients who have been resuscitated after severe hemorrhagic shock still have a high mortality rate. Previously published literature has suggested that remote ischemic postconditioning (RIPostC) has a cardioprotective effect, but few studies have focused on RIPostC performed after severe hemorrhagic shock. In this study, we aim to explore the effects and mechanism of RIPostC on myocardial ischemia and reperfusion injuries after hemorrhagic shock. METHODS: Fifty male rats were randomized into four groups: Sham, Control, RIPerC (remote ischemic per-conditioning) and RIPostC...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682942/protection-against-lipopolysaccharide-induced-immunosuppression-by-igg-and-igm
#13
Christiana Kyvelidou, Dimitris Sotiriou, Ioanna Zerva, Irene Athanassakis
Lipopolysaccharide (LPS) is commonly used in murine sepsis models, which are largely associated with immunosuppression and collapse of the immune system. After adapting the LPS treatment to the needs of locally bred BALB/c mice, the present study explored the potential role of IgG and IgM in reversing LPS endotoxemia. The established protocol consisted of five daily intraperitoneal injections of 0.2 μg/g LPS, which was tolerable by half of the manipulated animals. Such protocol allowed longer survival, necessary in the prospect of therapeutic treatment application...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682941/reduction-in-mortality-rates-of-postinjury-multiple-organ-dysfunction-syndrome-a-shifting-paradigm-a-prospective-population-based-cohort-study
#14
Karlijn J P van Wessem, Luke P H Leenen
INTRODUCTION: The incidence of Multiple Organ Dysfunction Syndrome (MODS) has decreased in the last decade by improvement in trauma care. However, it still remains a major cause of morbidity and mortality. This study investigated the current incidence and mortality of MODS in polytrauma patients. MATERIALS AND METHODS: A 3-year prospective study included consecutive trauma patients admitted to a Level-1 Trauma Center ICU. Isolated head injuries, drowning, asphyxiation and burns were excluded...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682940/monocyte-dependent-suppression-of-t-cell-function-in-postoperative-patients-and-abdominal-sepsis
#15
Markus Albertsmeier, Niclas J Prix, Hauke Winter, Alexandr Bazhin, Jens Werner, Martin K Angele
INTRODUCTION: Surgical trauma causes inflammation and postoperative immunosuppression. Previous studies have shown a T-cell dependent suppression of MHC II expression and other functions of antigen presenting cells. Aim of this study was to determine which immune cell initiates postoperative immunosuppression and consecutive sepsis. METHODS: We separated T-cells and monocytes in human abdominal surgery (n = 11) patients preoperatively as well as 24 hrs postoperatively and in patients who developed postoperative sepsis (n = 6)...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682939/burn-trauma-acutely-increases-the-respiratory-capacity-and-function-of-liver-mitochondria
#16
Fredrick J Bohanon, Omar Nunez Lopez, David N Herndon, Xiaofu Wang, Nisha Bhattarai, Amina El Ayadi, Anesh Prasai, Jayson W Jay, Yesenia Rojas-Khalil, Tracy E Toliver-Kinsky, Celeste C Finnerty, Ravi S Radhakrishnan, Craig Porter
BACKGROUND: A complete understanding of the role of the liver in burn-induced hypermetabolism is lacking. We investigated the acute effect of severe burn trauma on liver mitochondrial respiratory capacity and coupling control as well as the signaling events underlying these alterations. METHODS: Male BALB/c mice (8-12 weeks) received full-thickness scald burns on ∼30% of the body surface. Liver tissue was harvested 24 hours post injury. Mitochondrial respiration was determined by high-resolution respirometry...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28682938/improving-patient-selection-for-refractory-out-of-hospital-cardiac-arrest-treated-with-extracorporeal-life-support
#17
Tahar Chouihed, Antoine Kimmoun, Adrien Lauvray, Francois-Xavier Laithier, Deborah Jaeger, Simon Lemoine, Juan Pablo Maureira, Lionel Nace, Kevin Duarte, Stéphane Albizzati, Nicolas Girerd, Bruno Levy
BACKGROUND: Despite recent management improvement, including Extra-Corporeal Life Support (ECLS), refractory out-of-hospital cardiac arrest (ROHCA) survival remains dramatically low. METHODS: We assessed an innovative strategy (Out of hoSpital Cardiac ARrest-ExtraCorporeal Life Support - "OSCAR-ECLS") to optimize access to ECLS of ROHCA patients and reduce the delay between recognition and ECLS implantation. METHODS: This study, conducted in a tertiary teaching hospital, compared the survival and delay times of ROHCA patients treated by ECLS before and after OSCAR-ECLS implementation...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28661933/pyr-41-a-ubiquitin-activating-enzyme-e1-inhibitor-attenuates-lung-injury-in-sepsis
#18
Shingo Matsuo, Archna Sharma, Ping Wang, Weng-Lang Yang
During sepsis, systemic inflammation is observed and is associated with multiple organ failure. Activation of NF-κB is crucial for inducing inflammation, which is controlled by degradation of IκB. The ubiquitination proteasome pathway is responsible for the regulation of protein turnover. In this study, we hypothesized that administration of PYR-41, an inhibitor of ubiquitination, could reduce inflammation and organ injury in septic mice. PYR-41 prevented the reduction of IκB protein levels and inhibited release of TNF-α in mouse macrophage RAW264...
June 28, 2017: Shock
https://www.readbyqxmd.com/read/28658006/whole-blood-redox-potential-correlates-with-progressive-accumulation-of-oxygen-debt-and-acts-as-a-marker-of-resuscitation-in-a-swine-hemorrhagic-shock-model
#19
Rodney C Daniels, Hyesun Jun, M Hakam Tiba, Brendan McCracken, Pilar Herrera-Fierro, Maryanne Collinson, Kevin R Ward
INTRODUCTION: Oxidation-reduction reactions involve electron exchanges that require optimal balance for proper cell function. This balance is measured via redox potential and reflects oxidative stress. Despite the critical role of oxidative stress in critical illness and injury, little is known regarding redox potential. We hypothesize redox potential measurements will correlate with accumulation of O2 debt produced by hemorrhage over time. METHODS: Ten swine were studied using a polytrauma hemorrhagic shock model...
June 27, 2017: Shock
https://www.readbyqxmd.com/read/28658005/polysaccharides-from-bupleurum-induce-immune-reversal-in-late-sepsis
#20
Yue-Xin Wang, Qing-Yang Liu, Mei Zhang, Zhao Yang, Xin Pei, Xu Wu, Xin Chen, Jun Hong, Kai-Zhi Xu
BACKGROUND: Bupleurum chinense, a well-known Traditional Chinese Medicine, has been used for thousands of years in China. In this study, we would suggest that BPS could improve the prognosis of sepsis through its impact on redistribution of BMCs, which triggers immune reversal in late sepsis. METHODS: BALB/c mice were divided into five groups: sham burn group, burn plus P. aeruginosa group, burn plus P. aeruginosa with BPS (40 mg/kg, 100 mg/kg and 250 mg/kg) treatment group, and they were sacrificed at postburn day (PBD) 0, 3, 5 and 7...
June 27, 2017: Shock
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