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https://www.readbyqxmd.com/read/29215417/muramyl-dipeptide-enhances-thermal-injury-induced-autophagy-and-inflammatory-cytokine-response-of-lungs-via-activation-of-nod2-rick-signaling-pathway-in-rats
#1
Xiao-Jing Wu, Hui Liang, Ying Zhang, Xu-Ming Yang, Hong-Yu Wang, Hui Li, Xin-Yi Li, Kai Chen, Yan-Lin Wang, Jian-Guo Li, Zong-Ze Zhang, Xue-Min Song
OBJECTIVE: Nucleotide-binding oligomerization domain 2 (NOD2) is the innate receptor of muramyl dipeptide (MDP). Our previous study revealed that MDP could enhance thermal injury-induced inflammatory cytokine production and organ function injury in rats. The present study was to determine the effect of MDP on autophagy and NOD2/receptor-interacting serine/threonine protein kinases (RICK) signaling pathway of lung injury after thermal injury. METHODS: Forty male Sprague-Dawlay rats were randomly divided into four groups: normal control (NC) group, MDP group, Scald group and MDP + Scald group...
December 6, 2017: Shock
https://www.readbyqxmd.com/read/29206763/association-of-clinical-hypoperfusion-variables-with-lactate-clearance-and-hospital-mortality
#2
Jessica Londoño, César Niño, James Díaz, Carlos Morales, Jimmy León, Elisa Bernal, Cesar Vargas, Leonardo Mejía, Carolina Hincapié, Johana Ascuntar, Alba León, Fabián Jaimes
BACKGROUND: lactate has shown utility in assessing the prognosis of patients admitted to the hospital with confirmed or suspected shock. Some findings of the physical examination might replace it as screening tool. We asked to determine the correlation and association between clinical perfusion parameters and lactate at the time of admission; the correlation between the change in clinical parameters and lactate clearance after 6 and 24 hours of resuscitation and; the association between clinical parameters, lactate and mortality...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29206762/soluble-epoxide-hydrolase-plays-a-vital-role-in-angiotensin-ii-induced-lung-injury-in-mice
#3
Wei Tao, Ping-Song Li, Gang Xu, Yi Luo, Yu-Sheng Shu, Yong-Zhong Tao, Liu-Qing Yang
BACKGROUND: Angiotensin II plays a vital role in the pathogenesis of acute respiratory distress syndrome (ARDS). However, its mechanism is not well defined. Angiotensin II up-regulates the expression of soluble epoxide hydrolase (sEH; Ephx2). sEH is suggested as a potential pharmacologic target for ARDS. The present study investigates whether the sEH is involved in the angiotensin II triggered pulmonary inflammation and edema using an angiotensin II-induced lung injury animal model. METHODS: Lung injury was induced by angiotensin II intratracheally instillation in wild-type or Ephx2 deficient mice...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29206761/skeletal-muscle-mitochondrial-function-is-determined-by-burn-severity-sex-and-sepsis-and-is-associated-with-glucose-metabolism-and-functional-capacity-in-burned-children
#4
Victoria G Rontoyanni, Ioannis Malagaris, David N Herndon, Eric Rivas, Karel D Capek, Anahi D Delgadillo, Nisha Bhattarai, Armando Elizondo, Charles D Voigt, Celeste C Finnerty, Oscar E Suman, Craig Porter
BACKGROUND: Restoring normal mitochondrial function represents a new target for strategies aimed at mitigating the stress response to severe burn trauma and hastening recovery. Our objective was to investigate the determinants of skeletal muscle mitochondrial respiratory capacity and function and its association with glucose metabolism and functional capacity in burned children. METHODS: Data from burned children enrolled in the placebo arm of an ongoing prospective clinical trial were analyzed...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29206760/development-of-noninvasive-in-vivo-approach-to-assess-vascular-permeability-in-inflammation-using-fluorescence-imaging
#5
Takashi Shimazui, Taka-Aki Nakada, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Shigeto Oda
INTRODUCTION: In vivo fluorescence imaging can quantify vascular permeability without requiring sacrifice of animals. However, use of this noninvasive approach for vascular permeability assessment in remote organ injury caused by systemic inflammatory disease has not been reported. METHODS: Evans blue (EB) and Genhance 750 fluorescent dye were mixed and injected into mice. The lung as a remote organ and the footpad as a noninvasive observational site were assessed in a cecal ligation and puncture (CLP)-induced systemic inflammation mouse model and compared with sham and hydrocortisone pretreated (CLP + HC) mouse models...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29200137/early-prediction-of-persistent-organ-failure-by-circulating-endothelial-progenitor-cells-in-patients-with-acute-pancreatitis
#6
Jun Liu, Gui-Juan Zou, Long Yang, Shu Rong, Bai-Qiang Li, Zhi-Hui Tong, Wei-Qin Li, Jie-Shou Li
INTRODUCTION: Increased circulating endothelial progenitor cells (cEPC) have been observed in patients with vascular injury associated with sepsis and acute lung injury. However, a role for cEPC in severe acute pancreatitis (SAP) remains unclear. We therefore conducted a prospective study to study whether the quantities of cEPC can predict persistent organ failure (POF) in patients with predicted SAP. METHODS: A total of 42 predicted SAP patients who were admitted within 24 hours after symptom onset and 10 healthy control subjects were enrolled in our study...
December 1, 2017: Shock
https://www.readbyqxmd.com/read/29194344/direct-peritoneal-resuscitation-alters-leukocyte-infiltration-in-the-lung-after-acute-brain-death
#7
Jessica L Weaver, Paul J Matheson, Amy Matheson, Cynthia D Downard, R Neal Garrison, Jason W Smith
BACKGROUND: Brain death is associated with significant lung injury and inflammation. This has been associated with worse long-term outcomes for transplanted lungs. Direct peritoneal resuscitation (DPR) reduces systemic inflammation in brain death and improves lung procurement rate. The effect of DPR on macrophage and neutrophil infiltration in the lungs is not known. METHODS: Male Sprague-Dawley rats had a 4F Fogarty catheter inserted into the skull and the balloon inflated until brain death was achieved...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29194343/blood-mixing-upregulates-platelet-membrane-bound-cd40-ligand-expression-in-vitro-independent-of-abo-compatibility
#8
Go-Shine Huang, Mei-Hua Hu, Tso-Chou Lin, Yi-Chang Lin, Yi-Ting Tsai, Chih-Yuan Lin, Hung-Yen Ke, Xu-Zhi Zheng, Chien-Sung Tsai
Platelets play a central role in the inflammation response via CD40 ligand (CD40L) expression, which may lead to transfusion reactions. The precise role of platelet CD40L-mediated inflammation in transfusion reactions is unclear. Therefore, we assessed the effects of in vitro blood mixing on platelet CD40L expression. In addition, we examined the effect of ABO compatibility on CD40L expression. Donor packed red blood cells were acquired from a blood bank, and recipient blood was obtained from patients undergoing cardiac surgery and prepared as washed platelets...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29194342/tim-3-regulates-tregs-ability-to-resolve-the-inflammation-and-proliferation-of-acute-lung-injury-by-modulating-macrophages-polarization
#9
Xiandong Liu, Sen Jiang, Qian Zhang, Shumin Xu, Xiaowei Bao, Wei Cao, Jianwen Bai, Lunxian Tang
We recently reported that CD4CD25 regulatory T cells (Tregs) contributed to the recovery of patients with acute lung injury (ALI) by upregulating T cell immunoglobulin and mucin-domain containing-3 (Tim-3). However, the molecular mechanism by which Tim-3 regulates Tregs' function in the resolution and fibroproliferation after ALI remains unknown. In this study, we adoptively transferred Tim-3Tregs or Tim-3Tregs into LPS-induced ALI mice model. Data demonstrated that Tim-3Tregs not only decreased indices of lung inflammation and injury but also mitigated lung fibrosis after ALI...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29194341/applying-positive-end-expiratory-pressure-during-mechanical-ventilation-causes-pulmonary-redox-imbalance-and-inflammation-in-rats
#10
Mônica C Andrade, Ana B Farias Souza, Jacques G Horta, Guilherme de Paula Costa, André Talvani, Sílvia D Cangussú, Rodrigo C A de Menezes, Frank S Bezerra
BACKGROUND: Mechanical ventilation (MV) may induce or aggravate lung injury through the production of cytokines, inflammatory infiltration of neutrophils, and changes in the permeability of the alveolar-capillary barrier. The use of positive end-expiratory pressure (PEEP) helps improve gas exchanges avoiding alveolar collapse at the end of expiration. The present study aimed to analyze inflammatory response and redox imbalance in lungs of rats submitted to MV with and without PEEP. METHODS: Eighteen Wistar rats were divided into three groups: control (CG), PEEP group (PG), and zero PEEP (ZEEP) group (ZG)...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29194340/heat-shock-factor-1-inhibits-the-expression-of-suppressor-of-cytokine-signaling-3-in-cerulein-induced-acute-pancreatitis
#11
Guiliang Wang, Gui Xiao, Hai Liu, Guangwen Chen, Xiaoli Wang, Ping Wen, Ting Li, Jianbo Wen, Xianzhong Xiao
BACKROUND: Heat shock factor 1 (HSF1), an important transcriptional molecules in the heat shock process, can regulate the expression of a lot of inflammatory mediators in addition to heat shock proteins (HSPs). This study evaluated HSF1 inhibited the expression of suppressor of cytokine signaling 3 in cerulein-induced acute pancreatitis. METHODS: After HSF1+/+ mice, HSF1-/- mice and AR42J cells were treated with cerulein, histopathological score, expression of SOCS3 mRNA and protein levels were analyzed by uing RT-PCR, quantitative real-time RT-PCR and western blotting respectively...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29194339/risk-factors-for-the-development-of-acute-respiratory-distress-syndrome-following-hemorrhage
#12
Bryce R H Robinson, Mitchell J Cohen, John B Holcomb, Timothy A Pritts, Dina Gomaa, Erin E Fox, Richard D Branson, Rachael A Callcut, Bryan A Cotton, Martin A Schreiber, Karen J Brasel, Jean-Francois Pittet, Kenji Inaba, Jeffery D Kerby, Thomas M Scalea, Charlie E Wade, Eileen M Bulger
BACKGROUND: The Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) study evaluated the effects of plasma and platelets on hemostasis and mortality after hemorrhage. The pulmonary consequences of resuscitation strategies that mimic whole blood, remain unknown. METHODS: A secondary analysis of the PROPPR study was performed. Injured patients predicted to receive a massive transfusion were randomized to 1:1:1 vs. 1:1:2 plasma-platelet-RBC ratios at 12 Level I North American trauma centers...
November 30, 2017: Shock
https://www.readbyqxmd.com/read/29189604/2017-military-supplement-to-shock-journal-perftorantm-vidaphortm-introduction-to-western-medicine
#13
Gary W Latson
Perftoran, which has been re-branded as Vidaphorfor marketing in North America, is an emulsion of perfluorocarbons in a surfactant and electrolyte mixture. It was developed in Russia as an oxygen-carrying intravenous plasma additive for hemorrhagic anemia and ischemic conditions from various etiologies. It was approved for clinical use in Russia in 1996 and used by the Russian Armed Forces and in civilian medical care. It was also approved in Mexico from 2005 to 2010. It has been reportedly administered to over 35,000 patients with significant evidence of benefit and relatively mild and manageable adverse effects...
November 20, 2017: Shock
https://www.readbyqxmd.com/read/29189605/involvement-of-aromatic-metabolites-in-the-pathogenesis-of-septic-shock
#14
Natalia V Beloborodova, Yulia N Sarshor, Aleksandra Yu Bedova, Ekaterina A Chernevskaya, Alisa K Pautova
INTRODUCTION: We hypothesized that aromatic microbial metabolites (AMM), such as phenyllactic (PhLA), p-hydroxyphenylacetic (p-HPhAA), and p-hydroxyphenyllactic (p-HPhLA) acids, contribute to the pathogenesis of septic shock. METHODS: Clinical and laboratory data of patients with community-acquired pneumonia were obtained on intensive care unit admission and the next day. Patients were divided into two groups based on septic shock presence or absence. The levels of AMM (PhLA, p-HPhAA, p-HPhLA, and their sum, ∑3AMM), catecholamine metabolites (3,4-dihydroxymandelic [DHMA], 3,4-dihydroxyphenylacetic [DOPAC], and homovanillic [HVA] acids), lactate, N-terminal pro-brain natriuretic peptide (NT-proBNP), inducible nitric oxide synthase (iNOS), and procalcitonin (PCT) were compared...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29176405/lipopeptide-pam3cys4-synergizes-n-formyl-met-leu-phe-fmlp-induced-calcium-transients-in-mouse-neutrophils
#15
Renyu Ding, Ganqiong Xu, Yan Feng, Lin Zou, Wei Chao
N-Formyl-Met-Leu-Phe (fMLP), a mimic of N-formyl oligopeptides that are released from bacteria, is a potent leukocyte chemotactic factor. It induces intracellular calcium ([Ca]i) transient that is important for various neutrophil biological functions, e.g., adhesion, ROS and cytokine productions. Toll-like receptors (TLRs), an essential part of host innate immunity, regulate neutrophil activities, but their role in [Ca]i signaling is less clear. In the current study, we examined the effect of several TLR ligands, including Pam3Cys4 (TLR1/2), lipopolysaccharide (LPS, TLR4), and lipoteichoic acid (LTA, TLR2/6), on calcium signaling and on the fMLP-induced [Ca]i transients in mouse neutrophils loaded with Fura-2/AM...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29176404/antiplatelet-therapy-for-critically-ill-patients-a-pairwise-and-bayesian-network-meta-analysis
#16
Fangbing Du, Pan Jiang, Shengteng He, Dongming Song, Feng Xu
Antiplatelet therapy is an attractive treatment option for critically ill patients. However, more evidence on the benefit of this therapy is required. We searched the PubMed and Embase databases from their inception to June 2017 for randomized controlled trials and observational studies that assess the effect of antiplatelet therapy in critically ill patients. Antiplatelet therapy resulted in significant decreases in hospital mortality (risk ratio [RR] 0.81, 95% confidence interval [CI], 0.68-0.97; P = 0...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29176403/tlr4-and-nlrp3-caspase-1-il-1%C3%AE-axis-are-not-involved-in-colon-ascendens-stent-peritonitis-casp-associated-heart-disease
#17
Maria Micaela Lopez Alarcón, Julieta Fernández Ruocco, Fabiano Ferreira, Heitor A Paula-Neto, Marisa Sepúlveda, Martín Vila Petroff, Adriana Bastos Carvalho, Isalira Peroba Ramos, Hugo Justino Branda, Claudia Neto Paiva, Emiliano Medei
Hemodynamic collapse and myocardial dysfunction are among the major causes of death in severe sepsis. The purpose of this study was to assess the role played by TLR4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis. We performed the colon ascendens stent peritonitis (CASP) surgery in Tlr4, Nlrp3 and caspase-1 mice. We also assessed for the first time the electrical heart function in the CASP model. The QJ interval was increased in wild-type C57BL/6J mice after CASP when compared to sham controls, a result paralleled by an increase in the cardiac action potential duration (APD)...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29176402/clinical-outcomes-of-minimized-hydrocortisone-dosage-of-100%C3%A2-mg-day-on-lower-occurrence-of-hyperglycemia-in-septic-shock-patients
#18
Kanchana Ngaosuwan, Kanit Ounchokdee, Thep Chalermchai
BACKGROUND: The current international guideline recommended 200 mg per day of hydrocortisone intravenously to treat septic shock. However, a subsequent study on cortisol metabolism actually showed an increase in cortisol level during sepsis. Hence, the smaller hydrocortisone dose of 100 mg per day might be sufficient and reduce steroid-associated complications. We aimed to compare the clinical outcomes of minimized hydrocortisone dose of 100 mg to the currently recommended dose in the treatment of septic shock patients...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29176401/2017-military-supplement-dodecafluoropentane-emulsion-ddfpe-as-a-resuscitation-fluid-for-treatment-of-hemorrhagic-shock-and-traumatic-brain-injury-a-review
#19
Kaitlin Graham, Paula F Moon-Massat, Evan C Unger
Dodecafluoropentane emulsion (DDFPe) is a novel nanotechnology for oxygen delivery with therapeutic potential for hemorrhagic shock and/or traumatic brain injury (TBI). DDFPe demonstrates efficacy at smaller doses than previously tested perfluorocarbon oxygen therapeutics. This smaller dose potentially eliminates toxicities exhibited by previous oxygen therapeutics, while anti-inflammatory properties of DDFPe may alleviate damage from ischemia reperfusion injury. This mini-review summarizes our progress in developing a battle-field ready product to prevent combat death due to hemorrhagic shock and/or TBI...
November 15, 2017: Shock
https://www.readbyqxmd.com/read/29140832/platelet-function-changes-in-a-time-dependent-manner-following-traumatic-brain-injury-in-a-murine-model
#20
Grace E Martin, Brent Xia, Young Kim, Mark D Johnson, Rosalie Veile, Lou Ann Friend, Amy T Makley, Charles C Caldwell, Michael D Goodman
Traumatic brain injury (TBI) results in systemic changes in coagulation and inflammation that contribute to post-traumatic morbidity and mortality. The potential interaction of platelets and pro-inflammatory cytokines in the modulation of coagulation, microthrombosis, and venous thromboembolic events after moderate TBI (TBI) has not been determined. Using a murine model, we hypothesized 1) that the degree of platelet-induced coagulation varies depending on the platelet aggregation agonist 2) platelet-induced coagulation changes in a time-dependent manner following TBI, and 3) changes in platelet-induced coagulation are mirrored by changes in the levels of circulating pro-inflammatory cytokines...
November 14, 2017: Shock
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