journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Perinatology

journal
https://www.readbyqxmd.com/read/27866662/should-we-believe-in-transfusion-associated-enterocolitis-applying-a-grade-to-the-literature
#1
REVIEW
Susanne Hay, John A F Zupancic, Dustin D Flannery, Haresh Kirpalani, Dmitry Dukhovny
Numerous observational studies appear to demonstrate an association between packed red blood cell (pRBC) transfusions and necrotizing enterocolitis (NEC). However, the limited numbers of randomized controlled trials (RCTs) do not support a causal relationship between pRBC transfusion and NEC. We sought to determine the quality of the evidence behind transfusion-associated necrotizing enterocolitis (TANEC), and to formulate a GRADE-based recommendation regarding transfusion practices to reduce the risk of TANEC...
November 17, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27866661/a-critical-question-for-nec-researchers-can-we-create-a-consensus-definition-of-nec-that-facilitates-research-progress
#2
REVIEW
Phillip V Gordon, Jonathan R Swanson, Brianna C MacQueen, Robert D Christensen
In the last decades the reported incidence of preterm necrotizing enterocolitis (NEC) has been declining in large part due to implementing comprehensive NEC prevention initiatives, including breast milk feeding, standardized feeding protocols, transfusion guidelines, and antibiotic stewardship and improving the rigor with which non-NEC cases are excluded from NEC data. However, after more than 60 years of NEC research in animal models, the promise of a "magic bullet" to prevent NEC has yet to materialize. There are also serious issues involving clinical NEC research...
November 17, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27865437/early-neurodevelopmental-outcomes-of-extremely-preterm-infants
#3
REVIEW
Elizabeth E Rogers, Susan R Hintz
Infants born at extreme preterm gestation are at risk for both death and disability. Although rates of survival have improved for this population, and some evidence suggests a trend toward decreased neuromotor impairment over the past decades, a significant improvement in overall early neurodevelopmental outcome has not yet been realized. This review will examine the rates and types of neurodevelopmental impairment seen after extremely preterm birth, including neurosensory, motor, cognitive, and behavioral outcomes...
November 16, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27863707/outcomes-in-childhood-following-therapeutic-hypothermia-for-neonatal-hypoxic-ischemic-encephalopathy-hie
#4
REVIEW
Girija Natarajan, Athina Pappas, Seetha Shankaran
In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described...
November 15, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27863706/advanced-neuroimaging-and-its-role-in-predicting-neurodevelopmental-outcomes-in-very-preterm-infants
#5
REVIEW
Nehal A Parikh
Up to 35% of very preterm infants survive with neurodevelopmental impairments (NDI) such as cognitive deficits, cerebral palsy, and attention deficit disorder. Advanced MRI quantitative tools such as brain morphometry, diffusion MRI, magnetic resonance spectroscopy, and functional MRI at term-equivalent age are ideally suited to improve current efforts to predict later development of disabilities. This would facilitate application of targeted early intervention therapies during the first few years of life when neuroplasticity is optimal...
November 15, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27856003/in-their-own-words-life-at-adulthood-after-very-premature-birth
#6
REVIEW
Saroj Saigal
Very premature infants born in the last century following the early days of post-neonatal intensive care have demonstrated an array of physical, emotional, and mental health problems as they approach their third and fourth decades. These outcomes have been well documented by several international investigators. However, there is a paucity of information on the personal perspectives of these individuals with regard to their own quality of life, their hopes and their fears. This article will focus on the objective information from the published literature and how it differs from the personal perspectives of former very premature infants...
November 14, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27842712/defining-outcomes-for-high-risk-infants-problems-and-possibilities
#7
EDITORIAL
Susan R Hintz, Robert L Hess
No abstract text is available yet for this article.
November 11, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836427/genetic-alterations-in-necrotizing-enterocolitis
#8
REVIEW
Alain Cuna, Venkatesh Sampath
An underlying genetic predisposition to necrotizing enterocolitis (NEC) is increasingly being recognized. Candidate gene or pathway approaches as well as genome-wide approaches are beginning to identify potential pathogenic variants for NEC in premature infants. However, a majority of these studies have not yielded definitive results because of limited sample size and lack of validation. Despite these challenges, understanding the contribution of genetic variation to NEC is important for providing new insights into the pathogenesis of NEC as well as allowing for targeted care of infants with inherent susceptibility...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836426/introduction
#9
EDITORIAL
Michael S Caplan
No abstract text is available yet for this article.
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836425/necrotizing-a-historical-perspective
#10
REVIEW
Michael S Caplan, Avroy Fanaroff
Necrotizing enterocolitis is a devastating disease afflicting premature infants, though after 50 years of investigation, the pathophysiology remains elusive. This report describes the possible etiologic factors from a historical perspective, and outlines the importance of human milk, intestinal blood flow, and intestinal blood flow changes from a developmental perspective over the last 40-50 years.
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836424/executive-function-in-children-born-preterm-risk-factors-and-implications-for-outcome
#11
REVIEW
H Gerry Taylor, Caron A C Clark
Executive function (EF) refers to the set of cognitive processes involved in the self-regulation of emotion and goal-directed behavior. These skills and the brain systems that support them develop throughout childhood and are frequently compromised in preterm children, even in those with broadly average global cognitive ability. Risks for deficits in EF in preterm children and attendant problems in learning and psychosocial functioning are higher in those with more extreme prematurity, neonatal complications, and related brain abnormalities...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836423/impact-of-probiotics-on-necrotizing-enterocolitis
#12
REVIEW
Mark A Underwood
A large number of randomized placebo-controlled clinical trials and cohort studies have demonstrated a decrease in the incidence of necrotizing enterocolitis with administration of probiotic microbes. These studies have prompted many neonatologists to adopt routine prophylactic administration of probiotics while others await more definitive studies and/or probiotic products with demonstrated purity and stable numbers of live organisms. Cross-contamination and inadequate sample size limit the value of further traditional placebo-controlled randomized controlled trials...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836422/surgical-necrotizing-enterocolitis
#13
REVIEW
Jamie R Robinson, Eric J Rellinger, L Dupree Hatch, Joern-Hendrik Weitkamp, K Elizabeth Speck, Melissa Danko, Martin L Blakely
Although currently available data are variable, it appears that the incidence of surgical necrotizing enterocolitis (NEC) has not decreased significantly over the past decade. Pneumoperitoneum and clinical deterioration despite maximal medical therapy remain the most common indications for operative treatment. Robust studies linking outcomes with specific indications for operation are lacking. Promising biomarkers for severe NEC include fecal calprotectin and S100A12; serum fatty acid-binding protein; and urine biomarkers...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27836421/human-milk-is-the-feeding-strategy-to-prevent-necrotizing-enterocolitis
#14
REVIEW
Diana Maffei, Richard J Schanler
Human milk is the preferred diet for preterm infants as it protects against a multitude of NICU challenges, specifically necrotizing enterocolitis. Infants who receive greater than 50% of mother's own milk (MOM) in the 2 weeks after birth have a significantly decreased risk of NEC. An additional factor in the recent declining rates of NEC is the increased utilization of donor human milk (DHM). This creates a bridge until MOM is readily available, thus decreasing the exposure to cow milk protein. Preterm infants are susceptible to NEC due to the immaturity of their gastrointestinal and immune systems...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27832931/cytokines-and-growth-factors-in-the-developing-intestine-and-during-necrotizing-enterocolitis
#15
REVIEW
Krishnan MohanKumar, Kopperuncholan Namachivayam, Thao T B Ho, Benjamin A Torres, Robin K Ohls, Akhil Maheshwari
Cytokines and growth factors play diverse roles in the uninflamed fetal/neonatal intestinal mucosa and in the development of inflammatory bowel injury during necrotizing enterocolitis (NEC). During gestational development and the early neonatal period, the fetal/premature intestine is exposed to high levels of many "inflammatory" cytokines and growth factors, first via swallowed amniotic fluid in utero and then, after birth, in colostrum and mother's milk. This article reviews the dual, seemingly counter-intuitive roles of cytokines, where these agents play a "trophic" role and promote maturation of the uninflamed mucosa, but can also cause inflammation and promote intestinal injury during NEC...
November 7, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27823817/update-on-simulation-for-the-neonatal-resuscitation-program
#16
REVIEW
Anne Ades, Henry C Lee
The goal of the Neonatal Resuscitation Program is to have a trained provider in neonatal resuscitation at every delivery. The Neonatal Resuscitation Program develops its course content on review of the scientific evidence available for the resuscitation of newborns. Just as importantly, the educational structure and delivery of the course are based on evidence and educational theory. Thus, as simulation became a more accepted model in medical education and evidence was developing suggesting benefit of simulation, the Neonatal Resuscitation Program officially added simulation into its courses in 2010...
November 4, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27817913/the-role-of-early-developmental-intervention-to-influence-neurobehavioral-outcomes-of-children-born-preterm
#17
REVIEW
Alicia Spittle, Karli Treyvaud
Children who are born preterm are at risk of adverse long-term neurobehavioral outcomes, including cognitive, motor, and behavioral impairments. Early developmental interventions that commence within the first year after preterm birth have a preventative focus, with the aim to positively influence the developmental trajectory. While there is a great deal of heterogeneity in the research trials to date, there is evidence that early developmental interventions have a moderate effect on cognitive and behavioral outcomes up to preschool age, with some evidence for improved motor outcomes...
November 3, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27817912/language-and-hearing-outcomes-of-preterm-infants
#18
REVIEW
Betty R Vohr
Multiple factors including degree of prematurity, neonatal morbidities, illness severity, hearing status, gender, language environment in the neonatal intensive care unit and in the home, maternal education level, social and environmental status of the family, and access to early intervention all contribute to the language outcomes of extremely preterm infants with and without hearing loss. Early screening, early diagnosis, and early intervention services by 6 months of age are necessary to optimize the language outcomes of preterm infants with permanent hearing loss...
November 3, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27810117/simulation-and-debriefing-in-neonatology-2016-mission-incomplete
#19
REVIEW
Louis P Halamek
Simulation can be an effective tool to facilitate the acquisition and maintenance of the cognitive, technical and behavioral skills necessary to carry out our mission in neonatology: the delivery of safe, effective and efficient care to our patients. Prominent examples of successful implementation of simulation within neonatology include the Neonatal Resuscitation Program, the International Pediatric Simulation Society, and the International Network for Simulation-Based Pediatric Innovation, Research and Education...
October 31, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27810116/simulation-training-for-primary-caregivers-in-the-neonatal-intensive-care-unit
#20
REVIEW
Jennifer Arnold, Maria Carmen G Diaz
Simulation is a hands-on educational modality that creates a safe, confidential learning environment that is closely aligned with the principles of patient- and family-centered care. This makes it an ideal training tool for families and caregivers of medically complex infants as they prepare for their care at home. Multidisciplinary collaboration and participation is vital to the success of these simulations and encourages the development of needs assessments and learning objectives that are congruent with the family's goals, beliefs, and culture...
October 31, 2016: Seminars in Perinatology
journal
journal
20240
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"