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Seminars in Nuclear Medicine

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https://www.readbyqxmd.com/read/29195620/pet-ct-in-lymphoma-current-overview-and-future-directions
#1
REVIEW
Bruce D Cheson
Over the past several decades, PET has emerged as critical to accurate staging and restaging of lymphomas. Nonetheless, a number of critical issues regarding its optimal use remain. Whereas risk-adapted strategies appear to improve the outcome of patients with Hodgkin lymphoma, results are less convincing in non-Hodgkin lymphoma. Assessment of metabolic tumor volume before treatment may permit novel induction strategies. New drugs that may induce an immune response may result in a false-positive FDG/PET scan, mandating modifications of current criteria to consider tumor flare reactions...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195619/pet-ct-in-radiation-therapy-planning
#2
REVIEW
Lena Specht, Anne Kiil Berthelsen
Radiation therapy (RT) is an important component of the management of lymphoma patients. Most lymphomas are metabolically active and accumulate 18F-fluorodeoxyglucose (FDG). Positron emission tomography with computer tomography (PET/CT) imaging using FDG is used routinely in staging and treatment evaluation. FDG-PET/CT imaging is now also used routinely for contouring the target for RT, and has been shown to change the irradiated volume significantly compared with CT imaging alone. Modern advanced imaging techniques with image fusion and motion management in combination with modern highly conformal RT techniques have increased the precision of RT, and have made it possible to reduce dramatically the risks of long-term side effects of treatment while maintaining the high cure rates for these diseases...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195618/metabolic-tumor-volume-metrics-in-lymphoma
#3
REVIEW
Lale Kostakoglu, St├ęphane Chauvie
Although visual assessment using the Deauville criteria is strongly recommended by guidelines for treatment response monitoring in all FDG-avid lymphoma histologies, the high rate of false-positives and concerns about interobserver variability have motivated the development of quantitative tools to facilitate objective measurement of tumor response in both routine and clinical trial settings. Imaging studies using functional quantitative measures play a significant role in profiling oncologic processes. These quantitative metrics allow for objective end points in multicenter clinical trials...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195617/pet-ct-for-staging-past-present-and-future
#4
REVIEW
Tarec Christoffer El-Galaly, Lars Christian Gormsen, Martin Hutchings
Accurate and reproducible staging is crucial for management of malignant lymphomas. Disease stage influences treatment decisions more significantly than any other clinical information in most lymphoma subtypes, and contributes with important prognostic information on its own or as part of clinical prognostic scores. Information derived from medical imaging is the single most important determinant of disease stage, and the introduction PET/CT for lymphoma has led to substantial changes in the concept as well as practice of lymphoma staging...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195616/pet-ct-for-lymphoma-post-therapy-response-assessment-in-other-lymphomas-response-assessment-for-autologous-stem-cell-transplant-and-lymphoma-follow-up
#5
REVIEW
Shawn Karls, Hina Shah, Heather Jacene
FDG-PET/CT is an established first-line diagnostic imaging tool used in the staging of most lymphomas and for post-therapy response assessment in Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). Many of the subtypes of lymphoid neoplasms classified by the World Health Organization demonstrate significant FDG-avidity or uptake; however, many guidelines and Lugano classification do not recommend the use of FDG-PET/CT in assessing response to therapy for these non-HL, non-DLBCL subtypes as a first-line diagnostic tool...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195615/pet-ct-for-lymphoma-post-therapy-response-assessment-in-hodgkin-lymphoma-and-diffuse-large-b-cell-lymphoma
#6
REVIEW
Carsten Kobe, Markus Dietlein, Dirk Hellwig
Over the course of many decades, combined chemotherapy and radiotherapy adapted to the stage of disease have become the optimal and standard treatment for Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma. Besides achieving optimized cure rates of the underlying disease, reduction of toxicity has become a major goal. Since the introduction of FDG-PET for the staging and restaging of patients with lymphoma, a high predictive value of F-18-FDG-PET in response assessment has been observed. Several PET-response-guided therapy regimens have already been established, and even more PET-adapted study designs are being tested in large study groups...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195614/guest-editorial
#7
EDITORIAL
Lale Kostakoglu
No abstract text is available yet for this article.
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195613/interim-fdg-pet-imaging-in-lymphoma
#8
REVIEW
Andrea Gallamini, Colette Zwarthoed
In the present article, the authors reviewed the rationale of FDG-PET/CT performed at an interim time point during therapy (iPET), focusing on the transition from standard, anatomical assessment of tumor shrinkage with CT to document a chemotherapy response, to the use of functional imaging with PET to assess chemosensitivity of the individual tumor. The prognostic or predictive role of iPET in different lymphoma subsets has been reviewed, with particular emphasis on early and advanced-stage Hodgkin lymphoma, diffuse large B-cell lymphoma, peripheral T-cell lymphoma, extranodal natural killer/T-cell lymphoma, and primary mediastinal B-cell lymphoma...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29195612/letter-from-the-editors
#9
EDITORIAL
M Donald Blaufox, Leonard M Freeman
No abstract text is available yet for this article.
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969767/comprehensive-auditing-in-nuclear-medicine-through-the-international-atomic-energy-agency-quality-management-audits-in-nuclear-medicine-program-part-2-analysis-of-results
#10
REVIEW
Maurizio Dondi, Leonel Torres, Mario Marengo, Teresa Massardo, Eyal Mishani, Annare Van Zyl Ellmann, Kishor Solanki, Angelika Bischof Delaloye, Enrique Estrada Lobato, Rodolfo Nunez Miller, Felix Barajas Ordonez, Diana Paez, Thomas Pascual
The International Atomic Energy Agency has developed a program, named Quality Management Audits in Nuclear Medicine (QUANUM), to help its Member States to check the status of their nuclear medicine practices and their adherence to international reference standards, covering all aspects of nuclear medicine, including quality assurance/quality control of instrumentation, radiopharmacy (further subdivided into levels 1, 2, and 3, according to complexity of work), radiation safety, clinical applications, as well as managerial aspects...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969766/comprehensive-auditing-in-nuclear-medicine-through-the-international-atomic-energy-agency-quality-management-audits-in-nuclear-medicine-quanum-program-part-1-the-quanum-program-and-methodology
#11
REVIEW
Maurizio Dondi, Leonel Torres, Mario Marengo, Teresa Massardo, Eyal Mishani, Annare Van Zyl Ellmann, Kishor Solanki, Angelika Bischof Delaloye, Enrique Estrada Lobato, Rodolfo Nunez Miller, Diana Paez, Thomas Pascual
An effective management system that integrates quality management is essential for a modern nuclear medicine practice. The Nuclear Medicine and Diagnostic Imaging Section of the International Atomic Energy Agency (IAEA) has the mission of supporting nuclear medicine practice in low- and middle-income countries and of helping them introduce it in their health-care system, when not yet present. The experience gathered over several years has shown diversified levels of development and varying degrees of quality of practice, among others because of limited professional networking and limited or no opportunities for exchange of experiences...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969765/applications-of-ventilation-perfusion-scintigraphy-in-surgical-management-of-chronic-obstructive-lung-disease-and-cancer
#12
REVIEW
Mark Tulchinsky, Joseph S Fotos, Kshama Wechalekar, Simin Dadparvar
Ventilation-perfusion scintigraphy (VPS) depicts the two main physiological processes that are fundamental to oxygen-dependent life. The test has affirmed its critical place in the evaluation of patients with lung cancer preparing for lung resection. The results of the study can differentiate patients who are very likely to survive surgery and the subsequent pulmonary function loss from those who are not. This review presents validated and evolving testing techniques for this critical indication. VPS has long been an integral part of the preoperative evaluation of lung transplant candidates, guiding the single lung grafts to the side with the worst function...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969764/the-role-of-pulmonary-scintigraphy-in-the-evaluation-of-adults-with-congenital-heart-disease
#13
REVIEW
Malak Itani, Manuela Matesan, Jitesh Ahuja, Mohamed Bermo, Asma S Habib, Christopher Goiney, Eric V Krieger, Hubert Vesselle
Adults with congenital heart disease represent a growing population with challenging and complex medical management. Pulmonary scintigraphy can play a valuable role in the evaluation and care of this patient population. We present a review of the variety of clinical scenarios where pulmonary scintigraphy can be helpful in the evaluation of adults with congenital heart disease, along with technical considerations associated with these studies.
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969763/peri-and-postsurgical-evaluations-of-renal-transplant
#14
REVIEW
Belkis Erbas
Renal transplantation is the best treatment of choice for patient with chronic renal insufficiency because it provides better quality of life and longer survival. Survival rates for grafts and patients have improved over the recent decades because of significant evolution of surgical techniques and immunosuppressive treatment. However, renal transplantation is still associated with several complications, which may result in poor outcome. Cause of allograft dysfunction, which occurs in the early or late post-transplantation period, should be recognized immediately, so that it can be managed correctly...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969762/bone-spect-ct-of-the-spine-foot-and-ankle-evaluation-of-surgical-patients
#15
REVIEW
Leah E Waldman, Stephen C Scharf
Radionuclide bone scanning has been used routinely in the evaluation of bone pathology for decades. The greatest strength of the procedure is its extreme sensitivity for bone metabolism, allowing it to distinguish between active and inactive bony abnormalities. The downside of this reliance on abnormal bone turnover is the relative lack of anatomical detail compared with ever-improving CT and MRI technology. Fusion imaging using SPECT/CT (SCT), PET/CT, and PET/MRI offers an opportunity to combine the sensitivity of nuclear medicine examinations with the anatomical detail of CT and MRI...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969761/role-of-nuclear-medicine-for-diagnosing-infection-of-recently-implanted-lower-extremity-arthroplasties
#16
REVIEW
Christopher J Palestro, Charito Love
Infection is an infrequent complication of lower extremity prosthetic joint surgery. Approximately one-third develop within 3 months (early), another third within 1 year (delayed), and the remainder more than 1 year (late) after surgery. Diagnosing prosthetic joint infection, especially in the early postoperative period during the first year, is challenging. Pain is almost always present. The presence of fever is variable, ranging from less than 5% to more than 40% of patients. Leukocytosis is a poor predictor of infection...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969760/biliary-leak-in-the-postsurgical-abdomen-a-primer-to-hida-scan-interpretation
#17
REVIEW
Manuela Matesan, Mohammed Bermo, Irene Cruite, Cheng-Han Shih, Saeed Elojeimy, Fatemeh Behnia, David Lewis, Hubert Vesselle
Postsurgical bile leaks can be associated with significant morbidity and even mortality, if not identified and treated at an early phase. Hepatobiliary iminodiacetic acid (HIDA) scan is an important test for detection of bile leaks in the postoperative abdomen. However, the lack of anatomical details on planar images can make interpretation difficult, especially in the setting of altered postsurgical anatomy. Familiarity with the expected postoperative appearance on HIDA scan and correlation with SPECT/CT or other imaging modalities when available are very important...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969759/sentinel-lymph-node-biopsy-procedures
#18
REVIEW
Valeria M Moncayo, Adina L Alazraki, Naomi P Alazraki, John N Aarsvold
Accurate staging of many cancers with no clinical evidence of lymph node involvement is often a critical component of the management of such cancers and is generally and historically accomplished by accurate pathological assessment of multiple nodes. Unfortunately, such assessment usually involves excision of the multiple nodes and can result in significant morbidities. Over the past half century, and particularly over the last quarter century, investigators have defined and refined the "sentinel lymph node(s)" concept and have developed and investigated sentinel lymph node biopsy (SLNB) procedures...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969758/fdg-pet-ct-in-the-postoperative-period-utility-expected-findings-complications-and-pitfalls
#19
REVIEW
Gunjan Garg, Mohammed Taoudi Benchekroun, Tony Abraham
FDG-PET/CT as a modality is increasingly used for detection of recurrence and for restaging in patients with clinical suspicion of malignancy, as well as in patients with elevated tumor markers. However, there are many pitfalls in the interpretation of these scans when the studies are performed after some treatment. Some of these are attributed to normal physiological distribution and are compounded when there are inflammatory changes occurring after surgery. The body's inherent response to the surgical insult results in this inflammation...
November 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28969757/letter-from-the-editors
#20
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
November 2017: Seminars in Nuclear Medicine
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