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Seminars in Nuclear Medicine

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https://www.readbyqxmd.com/read/30322481/novel-quantitative-pet-techniques-for-clinical-decision-support-in-oncology
#1
REVIEW
Habib Zaidi, Abass Alavi, Issam El Naqa
Quantitative image analysis has deep roots in the usage of positron emission tomography (PET) in clinical and research settings to address a wide variety of diseases. It has been extensively employed to assess molecular and physiological biomarkers in vivo in healthy and disease states, in oncology, cardiology, neurology, and psychiatry. Quantitative PET allows relating the time-varying activity concentration in tissues/organs of interest and the basic functional parameters governing the biological processes being studied...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322480/nuclear-medicine-imaging-of-prostate-cancer-in-the-elderly
#2
REVIEW
Paolo Castellucci, Cristina Nanni, Valentina Ambrosini
Due to the increasing life expectancy, the diagnosis of malignancy and treatment of elderly patients is becoming more common. Prostate cancer is particularly frequent in this setting. Many different approaches are now available, but some of them imply significant risks or collateral effects. In those patients an accurate evaluation of risk-to-benefit ratio is needed, and functional imaging such as PET/CT is important for the clinician to make the appropriate choice. PET/CT in prostate cancer is a well-tolerated procedure that can be used to accurately assess the tumor extent during the entire clinical history of the disease...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322479/diagnosis-and-monitoring-of-osteoporosis-with-18-f-sodium-fluoride-pet-an-unavoidable-path-for-the-foreseeable-future
#3
REVIEW
Catherine C Reilly, William Y Raynor, Abigail L Hong, Daniel C Kargilis, Jae S Lee, Austin G Alecxih, Nishtha Gupta, Marie K Lim, Abdullah Al-Zaghal, Thomas J Werner, Sylvia S Rhodes, Abass Alavi, Chamith S Rajapakse
The prevalence of metabolic bone diseases particularly osteoporosis and its precursor, osteopenia, continue to grow as serious global health issues today. On a worldwide perspective, 200million people suffer from osteoporosis and in 2005, over 2million fracture incidents were estimated due to osteoporosis in the United States. Currently, osteoporosis and other metabolic bone diseases are evaluated primarily through dual energy X-ray absorptiometry, and rarely by bone biopsy with tetracycline labeling or Technetium-99m (99m Tc) based bone scintigraphy...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322478/applications-of-pet-imaging-in-the-evaluation-of-musculoskeletal-diseases-among-the-geriatric-population
#4
REVIEW
Abdullah Al-Zaghal, William Raynor, Mohsen Khosravi, Ali Guermazi, Thomas J Werner, Abass Alavi
Medical imaging plays a particularly important role in the care of elderly patients, in whom complex symptomatology and a high prevalence of musculoskeletal diseases necessitate sensitive imaging modalities. MRI is the most commonly used imaging modality in the evaluation of various musculoskeletal disorders. The integration of positron emission technique and computed tomography as well as magnetic resonance imaging allows for generating complimentary data for accurate and quantitative diagnosis. This article highlights the implementations of molecular imaging probes in the assessment of prevalent musculoskeletal disorders among geriatric population with emphasis on osteoarthritis, osteoporosis, diabetic foot, and prosthetic joint infections...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322477/pet-imaging-in-movement-disorders
#5
REVIEW
Baijayanta Maiti, Joel S Perlmutter
Positron emission tomography (PET) has revealed key insights into the pathophysiology of movement disorders. This paper will focus on how PET investigations of pathophysiology are particularly relevant to Parkinson disease, a neurodegenerative condition usually starting later in life marked by a varying combination of motor and nonmotor deficits. Various molecular imaging modalities help to determine what changes in brain herald the onset of pathology; can these changes be used to identify presymptomatic individuals who may be appropriate for to-be-developed treatments that may forestall onset of symptoms or slow disease progression; can PET act as a biomarker of disease progression; can molecular imaging help enrich homogenous cohorts for clinical studies; and what other pathophysiologic mechanisms relate to nonmotor manifestations...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322476/cognitive-impairment-and-dementias
#6
REVIEW
Mohsen Khosravi, Andrew Newberg, Abass Alavi
PET has been a key component in the diagnostic armamentarium for evaluating neurodegenerative diseases such as Alzheimer's or Parkinson's disease. PET imaging has been used for the diagnosis of these disorders, for identification of their pathophysiology, and for following treatment of these disorders. Further, PET imaging has been extensively used for both research and clinical purposes. This chapter will review the current literature with regard to PET imaging and neurodegenerative disorders. This includes an evaluation of the most commonly used tracer (FDG) that measures cerebral metabolism, as well as neurotransmitter tracers, and tracers designed to reveal specific pathophysiological processes...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322475/the-role-of-pet-in-evaluating-atherosclerosis-a-critical-review
#7
REVIEW
Mateen Moghbel, Abdullah Al-Zaghal, Thomas J Werner, Caius Mihail Constantinescu, Poul Flemming Høilund-Carlsen, Abass Alavi
Atherosclerosis is a common age-related disorder and is the major cause of morbidity and mortality in the developed countries. Structural imaging techniques, such as CT and MRI, have been of limited value in early detection of atherosclerotic plaques, and therefore, there is a dire need for techniques that are highly sensitive and specific for this purpose. Over the past decade, PET imaging with FDG and NaF has been tested for detection and characterization of atherosclerotic plaques in the major coronary arteries...
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322474/letter-from-the-guest-editors
#8
EDITORIAL
Abass Alavi, Poul Flemming Høilund-Carlsen
No abstract text is available yet for this article.
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322473/correction
#9
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30322472/letter-from-the-editors
#10
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
November 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193652/spect-ct-in-postoperative-shoulder-pain
#11
REVIEW
Mathilde Thélu-Vanysacker, Paycha Frédéric, Thélu Charles-Edouard, Bailliez Alban, Bonnevialle Nicolas, Blaire Tanguy
Over the last 2 decades, the incidence of prosthetic shoulder replacements has increased considerably, leading to a rising number of complications and reoperations. In this article, we review how SPECT/CT can be of significant clinical value for shoulder surgeons. Bone SPECT/CT can provide the correct diagnosis for different types of mechanical complications: glenoiditis after hemiarthroplasty, glenoidal loosening after total shoulder arthroplasty, and scapular notching after reverse shoulder arthroplasty. Various nuclear medicine methods are available for detecting prosthesis infection...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193651/spect-ct-in-postoperative-foot-and-ankle-pain
#12
REVIEW
Willm Uwe Kampen, Florian Westphal, Tim Van den Wyngaert, Klaus Strobel, Torsten Kuwert, Wouter Van der Bruggen, Gopinath Gnanasegaran, Jan-Hauke Jens, Frédéric Paycha
Postoperative pain is a clinically relevant issue in orthopedic patients, affecting more than 40% 1 year after foot and ankle surgery. Because of the very complex anatomy with many different joints and several motion axes, clinical examination and conventional imaging are sometimes not sufficient to identify a local pain generator. Local uptake of bone-seeking radiopharmaceuticals is known to correlate accurately with sites of pain generating foci and, thus, bone scintigraphy has been an established method to evaluate these respective patients for many years...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193650/spect-ct-in-the-postoperative-painful-knee
#13
REVIEW
Wouter van der Bruggen, Michael T Hirschmann, Klaus Strobel, Willm Uwe Kampen, Torsten Kuwert, Gopinath Gnanasegaran, Tim Van den Wyngaert, Frédéric Paycha
This review summarizes the role of SPECT/CT in patients with a painful postoperative knee and describes typical diagnostic criteria in these patients. Pain after knee surgery is common and is influenced by the underlying pathology, the type of surgery, and the patient. Knee joint-preserving surgery includes osteotomy, ligament reconstruction, meniscus surgery, and cartilage repair procedures, often used in combination. Knee arthroplasty procedures consist of unicondylar, patellofemoral, and primary or revision total knee prosthesis...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193649/spect-ct-in-postoperative-painful-hip-arthroplasty
#14
REVIEW
Tim Van den Wyngaert, Frédéric Paycha, Klaus Strobel, Willm Uwe Kampen, Torsten Kuwert, Wouter van der Bruggen, Gopinath Gnanasegaran
Consecutive milestones in hip arthroplasty design and surgical technique have contributed to the successful and cost-effective intervention this procedure has become today in maintaining mobility and quality of life in patients with osteoarthritis, fracture, or other hip conditions. With the increasing prevalence of hip joint replacements, the need for improved diagnostic imaging tools to guide revision surgery has risen in parallel. Over the last few years, promising data have emerged on the potential role of bone SPECT/CT imaging in the assessment of patients with recurrent pain after arthroplasty...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193648/bone-spect-ct-in-postoperative-spine
#15
REVIEW
Gopinath Gnanasegaran, Frédéric Paycha, Klaus Strobel, Wouter van der Bruggen, Willm Uwe Kampen, Torsten Kuwert, Tim Van den Wyngaert
Back pain is a common problem and the diagnosis and treatment depend on the clinical presentation, yet overlap between pain syndromes is common. Imaging of patients with chronic back pain in both pre- and postoperative scenarios include radiological, radionuclide, and hybrid techniques. In general, these techniques have their own advantages and limitations. The aim of surgery is to eliminate pathologic segmental motion and accompanying symptoms, especially pain. However, surgical procedures are not without complications and localizing the cause of the pain is often challenging...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193647/spect-ct-in-postoperative-hand-and-wrist-pain
#16
REVIEW
Klaus Strobel, Wouter van der Bruggen, Urs Hug, Gopinath Gnanasegaran, Willm Uwe Kampen, Torsten Kuwert, Frédéric Paycha, Tim van den Wyngaert
In this review we summarize the current evidence and experience regarding the performance of SPECT/CT in the evaluation of patients with postoperative painful wrist or hand. There is a wide range of operative wrist and hand interventions due to congenital, traumatic, degenerative, or inflammatory diseases. A significant number of patients suffer from pain after operative procedures. Several imaging modalities have been used to evaluate the reason for painful postoperative wrists like standard conventional x-rays, ultrasound, CT, MRI, or bone scintigraphy...
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193646/letter-from-the-guest-editors
#17
EDITORIAL
Frederic Paycha, Gopinath Gnanasegaran, Tim Van den Wyngaert
No abstract text is available yet for this article.
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/30193645/letter-from-the-editors
#18
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
September 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852947/snmmi-procedure-standard-eanm-practice-guideline-for-diuretic-renal-scintigraphy-in-adults-with-suspected-upper-urinary-tract-obstruction-1-0
#19
Andrew T Taylor, David C Brandon, Diego de Palma, M Donald Blaufox, Emmanuel Durand, Belkis Erbas, Sandra F Grant, Andrew J W Hilson, Anni Morsing
No abstract text is available yet for this article.
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852946/radiation-imagers-for-quantitative-single-particle-digital-autoradiography-of-alpha-and-beta-particle-emitters
#20
REVIEW
Brian W Miller
Promising therapies are being developed or are in early-stage clinical trials that employ the use of alpha- and beta-emitting radionuclides to cure hematologic malignancies. However, these targeted radionuclide therapies have not yet met their expected potential for cancer treatment. A primary reason is lack of biodistribution, dosimetry, and dose-response information at cellular levels, which are directly related to optimal targeting, achieving a requisite therapeutic dose, and assessing the safety profile in normal organs and tissues...
July 2018: Seminars in Nuclear Medicine
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