journal
MENU ▼
Read by QxMD icon Read
search

Seminars in Nuclear Medicine

journal
https://www.readbyqxmd.com/read/27825434/radium-223-therapy-of-bone-metastases-in-prostate-cancer
#1
REVIEW
Sten Nilsson
Metastatic castration-resistant prostate cancer frequently metastasizes to the bone, often resulting in painful skeletal events, reduced quality of life, and reduced survival. Radium-223 is a first-in-class alpha-emitting radiopharmaceutical that has proven to prolong overall survival, delay time to symptomatic skeletal events, and improve quality of life in patients with castration-resistant prostate cancer and symptomatic bone metastases and no visceral metastases. Radium-223 provides survival benefit to patients with castration-resistant prostate cancer and symptomatic bone metastases, regardless of prior docetaxel use...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825433/advancement-of-mr-and-pet-mr-in-prostate-cancer
#2
REVIEW
Liza Lindenberg, Mark Ahlman, Baris Turkbey, Esther Mena, Peter Choyke
Multiparametric magnetic resonance (mpMRI) imaging has assumed a larger role in the diagnosis and management of prostate cancer. The current method of detecting prostate cancer relies on blind systematic biopsy, guided only by transrectal ultrasound that generally directs the needle biopsy to sextants of the prostate rather than specific lesions. MpMRI is playing an increasing role in the detection of primary cancer as it can visualize cancers and direct biopsies. However, even mpMRI is inherently nonspecific and numerous biopsies performed under MR guidance prove to be negative...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825432/psma-pet-and-radionuclide-therapy-in-prostate-cancer
#3
REVIEW
Kirsten Bouchelouche, Baris Turkbey, Peter L Choyke
Prostate cancer (PCa) is the most common malignancy in men and a major cause of cancer death. Accurate imaging plays an important role in diagnosis, staging, restaging, detection of biochemical recurrence, and for therapy of patients with PCa. Because no effective treatment is available for advanced PCa, there is an urgent need to develop new and more effective therapeutic strategies. To optimize treatment outcome, especially in high-risk patients with PCa, therapy for PCa is moving rapidly toward personalization...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825431/pet-tracers-beyond-fdg-in-prostate-cancer
#4
REVIEW
David M Schuster, Cristina Nanni, Stefano Fanti
Conventional anatomical imaging with CT and MRI has limitations in the evaluation of prostate cancer. PET is a powerful imaging technique, which can be directed toward molecular targets as diverse as glucose metabolism, density of prostate-specific membrane antigen receptors, and skeletal osteoblastic activity. Although 2-deoxy-2-(18)F-FDG-PET is the mainstay of molecular imaging, FDG has limitations in typically indolent prostate cancer. Yet, there are many useful and emerging PET tracers beyond FDG, which provide added value...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825430/is-there-use-for-fdg-pet-in-prostate-cancer
#5
REVIEW
Hossein Jadvar
The use of positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) in prostate cancer depends on the phase of the disease along the natural history of this prevalent malignancy in men. Incidental high FDG uptake in the prostate gland, although rare, should prompt further investigation with at least a measurement of serum prostate specific antigen level. Although in general FDG uptake level may significantly overlap among normal, benign, and malignant tissues, aggressive primary tumors with Gleason score > 7 tend to display high FDG uptake...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825429/-18-f-naf-pet-ct-and-99m-tc-mdp-bone-scintigraphy-in-the-detection-of-bone-metastases-in-prostate-cancer
#6
REVIEW
Werner Langsteger, Alireza Rezaee, Christian Pirich, Mohsen Beheshti
(99m)Tc-MDP whole-body bone scintigraphy is a highly sensitive imaging method that has been used for decades to evaluate prostate cancer bone metastasis based on its availability and low cost; however, because of accumulation of this radiotracer in degenerative, traumatic, and inflammatory lesions, it suffers from noncomparable specificity. The modality is also used to monitor response to therapy and to predict patients' prognosis. As planar imaging may not give enough information for lesion detection or anatomical localization, it can be supplemented with SPECT to increase image contrast particularly in the evaluation of small and complex skeleton...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825428/diagnostic-and-therapeutic-strategies-for-prostate-cancer
#7
REVIEW
Mary Nguyen-Nielsen, Michael Borre
Prostate cancer (PC) is a major disease that affects men's health worldwide. It is the second most common form of cancer in men, surpassed only by nonmelanoma skin cancers such as basal and squamous cell carcinomas. Diagnostic strategies with population screening for prostate cancer using prostate-specific antigen (PSA) has been surrounded with controversy and debated intensively ever since the PSA protein was first purified in 1979 by Wang et al. At the same time, advances in diagnostic imaging, surgery, radiation, and chemotherapy have increased the opportunity to effectively diagnose, treat, and manage PC...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825427/guest-editorial-prostate-cancer
#8
EDITORIAL
Kirsten Bouchelouche
No abstract text is available yet for this article.
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825426/erratum-to-evaluation-of-osseous-metastasis-in-bone-scintigraphy-semin-nucl-med-46-2016-340-358
#9
Amir Reza Jalilian, Davood Beiki, Arman Hassanzadeh-Rad, Arash Eftekhari, Parham Geramifar, Mohammad Eftekhari
No abstract text is available yet for this article.
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27825425/letter-from-the-editors
#10
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553471/renal-function-assessment-during-peptide-receptor-radionuclide-therapy
#11
REVIEW
Belkis Erbas, Murat Tuncel
Theranostics labeled with Y-90 or Lu-177 are highly efficient therapeutic approaches for the systemic treatment of various cancers including neuroendocrine tumors and prostate cancer. Peptide receptor radionuclide therapy (PRRT) has been used for many years for metastatic or inoperable neuroendocrine tumors. However, renal and hematopoietic toxicities are the major limitations for this therapeutic approach. Kidneys have been considered as the "critical organ" because of the predominant glomerular filtration, tubular reabsorption by the proximal tubules, and interstitial retention of the tracers...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553470/gallium-68-edta-pet-ct-for-renal-imaging
#12
REVIEW
Michael S Hofman, Rodney J Hicks
Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration and have been radiolabelled with a variety of isotopes for imaging glomerular filtration and quantitative assessment of glomerular filtration rate. Gallium-68 ((68)Ga) EDTA PET usage predates Technetium-99m ((99m)Tc) renal imaging, but virtually disappeared with the widespread adoption of gamma camera technology that was not optimal for imaging positron decay...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553469/gallium-68-pet-a-powerful-generator-based-alternative-to-infection-and-inflammation-imaging
#13
REVIEW
Mariza Vorster, Alex Maes, Christophe van de Wiele, Mike Sathekge
The process of inflammation (with or without infection) forms part of essentially every major debilitating disease. Early detection and accurate distinction of inflammation from infection are important to optimize and individualize therapy. Nuclear medicine is ideally suited for the detection of pathologic changes early on and is able to target a magnitude of role players involved in the aforementioned processes. Hybrid modalities such as PET/CT and PET/MRI offer high spatial resolution that combines morphologic and pathophysiological changes and add various quantification possibilities that are preferable in these settings...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553468/-68-ga-pet-ventilation-and-perfusion-lung-imaging-current-status-and-future-challenges
#14
REVIEW
Dale L Bailey, Enid M Eslick, Geoffrey P Schembri, Paul J Roach
Gallium-68 ((68)Ga) is a positron-emitting radionuclide suitable for positron emission tomography (PET) imaging that has a number of convenient features-it has a physical half life of 68 minutes, it is generator produced at the PET facility and needs no local cyclotron, and being a radiometal is able to be chelated to a number of useful molecules for diagnostic imaging with PET. (68)Ga has recently been investigated as a radiotracer for ventilation and perfusion (V/Q) lung imaging. It is relatively easy to produce both V/Q radiopharmaceuticals labeled with (68)Ga for PET studies, it offers higher spatial resolution than equivalent SPECT studies, the short half life allows for multiple (repeated) scans on the same day, and low amounts of radiotracer can be used thus limiting the radiation dose to the subject...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553467/angiogenesis-imaging-using-68-ga-rgd-pet-ct-therapeutic-implications
#15
REVIEW
Jae Seon Eo, Jae Min Jeong
Angiogenesis imaging is important for diagnostic and therapeutic treatment of various malignant and nonmalignant diseases. The Arg-Gly-Asp (RGD) sequence has been known to bind with the αvβ3 integrin that is expressed on the surface of angiogenic blood vessels or tumor cells. Thus, various radiolabeled derivatives of RGD peptides have been developed for angiogenesis imaging. Among the various radionuclides, (68)Ga was the most widely studied for RGD peptide imaging because of its excellent nuclear physical properties, easy-to-label chemical properties, and cost-effectiveness owing to the availability of a (68)Ge-(68)Ga generator...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553466/current-status-of-prostate-specific-membrane-antigen-targeting-in-nuclear-medicine-clinical-translation-of-chelator-containing-prostate-specific-membrane-antigen-ligands-into-diagnostics-and-therapy-for-prostate-cancer
#16
REVIEW
Clemens Kratochwil, Ali Afshar-Oromieh, Klaus Kopka, Uwe Haberkorn, Frederik L Giesel
The prostate-specific membrane antigen (PSMA) is expressed by approximately 90% of prostate carcinomas. The expression correlates with unfavorable prognostic factors, such as a high Gleason score, infiltrative growth, metastasis, and hormone-independence. The high specificity, especially in the undifferentiated stage, makes it an excellent target for diagnosis and therapy. Therefore, antibodies and small molecule inhibitors have been developed for imaging and therapy. In 2011 PSMA-11, a ligand that consists of the Glu-urea-motif and the chelator HBED-CC, which can be exclusively radiolabeled with (68)Ga for PET imaging, presented the clinical breakthrough for prostate cancer diagnostics...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553465/advances-in-the-diagnosis-of-neuroendocrine-neoplasms
#17
REVIEW
Harshad R Kulkarni, Aviral Singh, Richard P Baum
Somatostatin receptor PET/CT using (68)Ga-labeled somatostatin analogs, is a mainstay for the evaluation of the somatostatin receptor status in neuroendocrine neoplasms. In addition, the assessment of glucose metabolism by (18)F-FDG PET/CT at diagnosis can overcome probable shortcomings of histopathologic grading. This offers a systematic theranostic approach for the management of neuroendocrine neoplasms, that is, patient selection for the appropriate treatment-surgery, somatostatin analogs, peptide receptor radionuclide therapy, targeted therapies like everolimus and sunitinib, or chemotherapy-and also for therapy response monitoring...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553464/bifunctional-gallium-68-chelators-past-present-and-future
#18
REVIEW
Philipp Spang, Christian Herrmann, Frank Roesch
This article reviews the development of bifunctional chelates for synthesising (68)Ga radiopharmaceuticals. It structures the chelates into groups of macrocycles, nonmacrocycles, and chimeric derivatives. The most relevant bifunctional chelates are discussed in chelate structure, parameters of (68)Ga-labeling, and stability of the (68)Ga-chelate complexes. Furthermore those derivatives are included, where (67)Ga was applied instead of (68)Ga. A particular feature discussed is the ability of certain bifunctional chelate structures to function in kit-type preparation of the (68)Ga radiopharmaceuticals...
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553463/letter-from-the-guest-editor
#19
EDITORIAL
Mike Machaba Sathekge
No abstract text is available yet for this article.
September 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27553462/letter-from-the-editors
#20
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
September 2016: Seminars in Nuclear Medicine
journal
journal
20239
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"