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Seminars in Nuclear Medicine

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https://www.readbyqxmd.com/read/29852947/snmmi-procedure-standard-eanm-practice-guideline-for-diuretic-renal-scintigraphy-in-adults-with-suspected-upper-urinary-tract-obstruction-1-0
#1
REVIEW
Andrew T Taylor, David C Brandon, Diego de Palma, M Donald Blaufox, Emmanuel Durand, Belkis Erbas, Sandra F Grant, Andrew J W Hilson, Anni Morsing
No abstract text is available yet for this article.
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852946/radiation-imagers-for-quantitative-single-particle-digital-autoradiography-of-alpha-and-beta-particle-emitters
#2
REVIEW
Brian W Miller
Promising therapies are being developed or are in early-stage clinical trials that employ the use of alpha- and beta-emitting radionuclides to cure hematologic malignancies. However, these targeted radionuclide therapies have not yet met their expected potential for cancer treatment. A primary reason is lack of biodistribution, dosimetry, and dose-response information at cellular levels, which are directly related to optimal targeting, achieving a requisite therapeutic dose, and assessing the safety profile in normal organs and tissues...
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852945/innovations-in-nuclear-imaging-instrumentation-cerenkov-imaging
#3
REVIEW
Ryo Tamura, Edwin C Pratt, Jan Grimm
Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy...
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852944/absolute-quantitation-of-spect-studies
#4
REVIEW
Michael Ljungberg
Methods for absolute quantitation of SPECT images provide an estimate of the activity uptakes in various organs and tissues in units of (M)Bq or (m)Ci. However, because tomographic SPECT images generally are hampered by several physical and camera-specific effects, accurate and precise compensation methods are required. The most important effects are (1) photon attenuation in the patient resulting in a reduction of expected acquired count; (2) the contribution of events from photons, scattered in the phantom and the collimator but accepted by the energy window because of a poor energy resolution of the NaI(Tl) crystal; and (3) the effect of the collimator response function that degrades the image quality because of the relatively poor spatial resolution...
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852943/pet-mri-hybrid-systems
#5
REVIEW
Julia G Mannheim, Andreas M Schmid, Johannes Schwenck, Prateek Katiyar, Kristina Herfert, Bernd J Pichler, Jonathan A Disselhorst
Over the last decade, the combination of PET and MRI in one system has proven to be highly successful in basic preclinical research, as well as in clinical research. Nowadays, PET/MRI systems are well established in preclinical imaging and are progressing into clinical applications to provide further insights into specific diseases, therapeutic assessments, and biological pathways. Certain challenges in terms of hardware had to be resolved concurrently with the development of new techniques to be able to reach the full potential of both combined techniques...
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852942/innovations-in-instrumentation-for-positron-emission-tomography
#6
REVIEW
Eric Berg, Simon R Cherry
PET scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the 3-dimensional distribution of radiotracers inside the body. PET scanners are commonly integrated with x-ray CT or MRI scanners in hybrid devices that can provide both molecular imaging (PET) and anatomical imaging (CT or MRI). Despite decades of development, significant opportunities still exist to make major improvements in the performance of PET systems for a variety of clinical and research tasks...
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852941/guest-editorial
#7
EDITORIAL
Pat Zanzonico
No abstract text is available yet for this article.
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29852940/editorial-innovations-in-nuclear-medicine-instrumentation
#8
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
July 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626946/implementation-of-quality-systems-in-nuclear-medicine-why-it-matters-an-outcome-analysis-quality-management-audits-in-nuclear-medicine-part-iii
#9
REVIEW
Maurizio Dondi, Diana Paez, Leonel Torres, Mario Marengo, Angelika Bischof Delaloye, Kishor Solanki, Annare Van Zyl Ellmann, Enrique Estrada Lobato, Rodolfo Nunez Miller, Francesco Giammarile, Thomas Pascual
The International Atomic Energy Agency (IAEA) developed a comprehensive program-Quality Management Audits in Nuclear Medicine (QUANUM). This program covers all aspects of nuclear medicine practices including, but not limited to, clinical practice, management, operations, and services. The QUANUM program, which includes quality standards detailed in relevant checklists, aims at introducing a culture of comprehensive quality audit processes that are patient oriented, systematic, and outcome based. This paper will focus on the impact of the implementation of QUANUM on daily routine practices in audited centers...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626945/molecular-imaging-of-vulnerable-plaque
#10
REVIEW
Takehiro Nakahara, Jagat Narula, H William Strauss
Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis, V) expression of protease enzymes in the lesion, VI) development of microthrombi in late-phase lesions, VII) apoptosis, and VIII) microcalcification.
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626944/molecular-imaging-of-inflammatory-arthritis-and-related-disorders
#11
REVIEW
François Jamar, Annibale Versari, Filippo Galli, Frédéric Lecouvet, Alberto Signore
Rheumatic disorders comprise a number of diseases that range from benign, mildly symptomatic degenerative disease to severe systemic disorders such as giant-cell vasculitis with dramatic consequences such as acute blindness. The former is relatively common, whereas the latter is rare. In between, commonly encountered disorders such as rheumatoid arthritis and the various spondyloarthritides, with or without peripheral enthesitis, are daily challenges for the caring physician. Clinical evaluation is of utmost importance and is constantly described under the form of specialist guidelines in all parts of the world...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626943/new-spect-and-pet-radiopharmaceuticals-for-imaging-inflammatory-diseases-a-meta-analysis-of-the-last-10-years
#12
REVIEW
Marta Pacilio, Chiara Lauri, Daniela Prosperi, Agnese Petitti, Alberto Signore
Modern molecular nuclear medicine is rapidly developing in the field of imaging of chronic inflammatory diseases, and many new radiopharmaceuticals have been recently described and tested in animals and man. These can detect early pathophysiological changes before the development of anatomical changes and, often, before clinical onset of symptoms. This field includes new radiopharmaceuticals for SPECT and PET use to define new strategies for imaging immune cells as well as tissue modifications induced by the inflammatory process...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626942/nuclear-imaging-in-sarcoidosis
#13
REVIEW
Eve Piekarski, Khadija Benali, François Rouzet
Sarcoidosis is a multisystem granulomatosis which may result in a wide variety of clinical and biological presentations. Symptoms are often nonspecific, and incidental abnormal findings on chest radiography is rather common. Although sarcoidosis resolves favorably in most cases, some localizations can provoke functional impairment or even impact on patients' prognosis. The diagnosis is based on a pathological hallmark which is the non-necrotizing epithelioid-cell rich granuloma. Owing to the ability to detect inflammation throughout the body with a high sensibility, FDG-PET/CT gained a central role in sarcoidosis because it can suggest the diagnosis in certain clinical context, guide biopsy, evaluate the extent of the disease, help assess the prognosis, and monitor immunosuppressive therapy...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626941/imaging-macrophage-associated-inflammation
#14
REVIEW
Catherine A Foss, Julian Sanchez-Bautista, Sanjay K Jain
Macrophages belong to the mononuclear phagocyte system comprising closely related cells of bone marrow origin. Activated macrophages are critical in several diseases such as tuberculosis, sarcoidosis, Crohn's disease, and atherosclerosis. Noninvasive imaging techniques that can specifically image activated macrophages could therefore help in differentiating various forms of inflammatory diseases and to monitor therapeutic responses.
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626940/pet-mri-in-infection-and-inflammation
#15
REVIEW
Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A W J M Glaudemans, Riemer Slart, Paola Anna Erba
Hybrid positron emission tomography/magnetic resonance imaging (PET/MR) systems are now more and more available for clinical use. PET/MR combines the unique features of MR including excellent soft tissue contrast, diffusion-weighted imaging, dynamic contrast-enhanced imaging, fMRI and other specialized sequences as well as MR spectroscopy with the quantitative physiologic information that is provided by PET. Most of the evidence of the potential clinical utility of PET/MRI is available for neuroimaging. Other areas, where PET/MR can play a larger role include head and neck, upper abdominal, and pelvic tumours...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626939/the-3m-approach-to-cardiovascular-infections-multimodality-multitracers-and-multidisciplinary
#16
REVIEW
Martina Sollini, Raffaella Berchiolli, Roberto C Delgado Bolton, Alexia Rossi, Margarita Kirienko, Roberto Boni, Elena Lazzeri, Riemer Slart, Paola Anna Erba
Cardiovascular infections are associated with high morbidity and mortality. Early diagnosis is crucial for adequate patient management, as early treatment improves the prognosis. The diagnosis cannot be made on the basis of a single symptom, sign, or diagnostic test. Rather, the diagnosis requires a multidisciplinary discussion in addition to the integration of clinical signs, microbiology data, and imaging data. The application of multimodality imaging, including molecular imaging techniques, has improved the sensitivity to detect infections involving heart valves and vessels and implanted cardiovascular devices while also allowing for early detection of septic emboli and metastatic infections before these become clinically apparent...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626938/guest-editorial-on-molecular-imaging-of-infection-and-inflammation
#17
EDITORIAL
Christopher J Palestro
No abstract text is available yet for this article.
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29626937/letter-from-the-editors-may-2018-issue
#18
EDITORIAL
Leonard M Freeman, M Donald Blaufox
No abstract text is available yet for this article.
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452623/currently-available-radiopharmaceuticals-for-imaging-infection-and-the-holy-grail
#19
REVIEW
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452622/letter-from-the-guest-editor
#20
EDITORIAL
Christopher J Palestro
No abstract text is available yet for this article.
March 2018: Seminars in Nuclear Medicine
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