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Reproductive Biomedicine Online

Meng Rao, Fang Zhou, Li Tang, Zhengyan Zeng, Shifu Hu, Yingying Wang, Dandan Ke, Guiping Cheng, Wei Xia, Ling Zhang, Changhong Zhu
RESEARCH QUESTION: Is humanin present in the human ovary and follicular fluid? What relationship exists between humanin concentration in the follicular fluid and ovarian reserve and clinical outcomes after IVF and intracytoplasmic sperm injection (ICSI)? DESIGN: Follicular fluid samples were collected from 179 patients undergoing their first IVF or ICSI cycle during oocyte retrieval. Ovarian tissues were collected from two patients undergoing surgery for ovarian cysts...
November 23, 2018: Reproductive Biomedicine Online
Haotian Wu, Alexandra M Huffman, Brian W Whitcomb, Srinihaari Josyula, Suzanne Labrie, Ellen Tougias, Tayyab Rahil, Cynthia K Sites, Jonathan Richard Pilsner
RESEARCH QUESTION: To examine associations between sperm mitochondrial DNA copy number (mtDNAcn), sperm mitochondrial DNA deletions (mtDNAdel), semen parameters and clinical infertility in an IVF setting. DESIGN: A total of 125 sperm samples were collected from men undergoing assisted reproductive procedures in an IVF clinic in Western Massachusetts, USA. Sperm mtDNAcn and mtDNAdel were measured by probe-based quantitative polymerase chain reaction. Semen parameters, clinical diagnoses of infertility, and infertility based on consecutive semen parameters, were fitted with mtDNAcn and mtDNAdel in linear models...
November 16, 2018: Reproductive Biomedicine Online
Katarina Kebbon Vaegter, Lars Berglund, Johanna Tilly, Nermin Hadziosmanovic, Thomas Brodin, Jan Holte
RESEARCH QUESTION: Elective single-embryo transfer (eSET) at blastocyst stage is widely used to reduce the frequency of multiple pregnancies after IVF. There are, however, concerns about increased risks for the offspring with prolonged embryo culture. Is it possible to select embryos for transfer at the early cleavage stage and still achieve low twin rates at preserved high live birth rates? DESIGN: A prediction model (PM) was developed to optimize eSET based on variables known 2 days after oocyte retrieval (fresh day 2 embryo transfers; double-embryo transfers 1999-2002 (n=2846) and SET 1999-2003 (n=945); n total=3791)...
November 14, 2018: Reproductive Biomedicine Online
Anne Mayeur, Naouel Ahdad, Laetitia Hesters, Sophie Brisset, Serge Romana, Lucie Tosca, Gérard Tachdjian, Nelly Frydman
RESEARCH QUESTION: Chromosomal translocations are known genetic causes of male infertility. Are certain translocations or chromosomal regions more directly associated with sperm defects? Is there a threshold of sperm impairment that can be relevant for detection of translocations? DESIGN: This is a monocentric retrospective observational study covering a 10-year period. Eighty-one patients carrying a reciprocal translocation (RCT) and 63 carrying a Robertsonian translocation (ROBT) were compared with 105 fertile patients...
November 13, 2018: Reproductive Biomedicine Online
Tamar Margalit, Avi Ben-Haroush, Roni Garor, Naomi Kotler, Dania Shefer, Natalia Krasilnikov, Moran Tzabari, Galia Oron, Yoel Shufaro, Onit Sapir
RESEARCH QUESTION: Does delayed maturation of aspirated metaphase I (MI) oocytes, completed in vitro, adversely affect early embryo development? DESIGN: Time-lapse microscopy was used to compare morphokinetic variables between embryos derived from oocytes with delayed maturation after ovarian stimulation and from in-vivo-matured metaphase II (MII) sibling oocytes from the same IVF and intracytoplasmic sperm injection cycle. RESULTS: A total of 1545 injected oocytes in 169 cycles from 149 patients were included...
November 10, 2018: Reproductive Biomedicine Online
Ernesto Bosch, Carlo Bulletti, Alan B Copperman, Renato Fanchin, Hakan Yarali, Carlos A Petta, Nikolaos P Polyzos, Daniel Shapiro, Filippo Maria Ubaldi, Juan A Garcia Velasco, Salvatore Longobardi, Thomas D'Hooghe, Peter Humaidan
RESEARCH QUESTION: How might time to healthy singleton delivery affect decision-making during infertility treatment? DESIGN: This was a Delphi consensus investigating expert opinion that comprised three steps. In Step 1, 12 experts developed statements. In Step 2, 27 experts (including 12 from Step 1) voted (online survey) on their agreement/disagreement with each statement (providing reasons). Consensus was reached if ≥66% of participants agreed/disagreed. Statements not reaching consensus were revised and the process repeated until consensus was achieved...
November 7, 2018: Reproductive Biomedicine Online
Liu Shuling, Matthew Lau Sie Kuei, Seyed Ehsan Saffari, Zheng Jiayun, Tan Tse Yeun, Jessie Phoon Wai Leng, Veronique Viardot-Foucault, Sadhana Nadarajah, Jerry Kok Yen Chan, Tan Heng Hao
RESEARCH QUESTION: Previous studies of aromatase inhibitors on male infertility have focused on men with low testosterone-oestradiol ratio of less than 10. Can aromatase inhibitors improve spermatogenesis in men with idiopathic male infertility with normal testosterone-oestradiol ratio? DESIGN: Prospective study of men with idiopathic severe oligozoospermia (sperm concentration <5 million/ml) carried out between February 2015 and March 2017. The objective was to assess if semen-analysis parameters improved after treatment with letrozole...
October 30, 2018: Reproductive Biomedicine Online
Luciana Ferella, Juan Ignacio Bastón, Mariela Andrea Bilotas, José Javier Singla, Alejandro Martín González, Carla Noemí Olivares, Gabriela Fabiana Meresman
RESEARCH QUESTION: Can carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis? DESIGN: Primary stromal cell cultures were established from endometrial biopsies from women with endometriosis and controls. The human endometrial stromal cell line T-HESC was also used for in-vitro experiments. Endometriosis was surgically induced in BALB/c mice, which were randomly assigned to CA 2 mg/kg/day (n = 11); CA 20 mg/kg/day (n = 10); RA 1 mg/kg/day (n = 11); RA 3 mg/kg/day (n = 10); WG 20 mg/kg/day (n = 12); intraperitoneal vehicle control (n = 8) or oral vehicle control (n = 11)...
October 26, 2018: Reproductive Biomedicine Online
Sunita Sharma, Shikha Bathwal, Nupur Agarwal, Ratna Chattopadhyay, Indranil Saha, Baidyanath Chakravarty
RESEARCH QUESTION: Reports on the effect of adenomyosis on assisted reproductive technology (ART) outcomes are conflicting. Does presence of adenomyosis affect reproductive outcome in IVF cycles in women pretreated with gonadotrophin releasing hormone (GnRH) agonist? DESIGN: In this retrospective cohort study, 973 women were divided into four groups: only endometriosis (n = 355); endometriosis and adenomyosis (n = 88); adenomyosis alone (n = 64); and tubal factor infertility as controls (n = 466)...
October 26, 2018: Reproductive Biomedicine Online
Tingting Liu, Qiuyi Wang, Wei Huang, Jing Tan, Dong Liu, Tianjiao Pei, Xueying Li, Guojun Zhou
RESEARCH QUESTION: Which anthropometric index (waist-to-height ratio, waist circumference, waist-to-hip ratio and body mass index) is the best in predicting insulin resistance among Chinese women with polycystic ovary syndrome? DESIGN: A total of 1124 patients with polycystic ovary syndrome at the Reproductive Endocrinology Division of West China Second University Hospital of Sichuan University were enrolled in this study. Identification of insulin resistance was based on homeostasis model assessment of insulin resistance scores 2...
October 26, 2018: Reproductive Biomedicine Online
Elsje C Oostingh, Jennifer Hall, Maria P H Koster, Bola Grace, Eric Jauniaux, Régine P M Steegers-Theunissen
The main risk factors for important reproductive health issues such as subfertility and perinatal mortality largely originate in the periconception period. To evaluate associations between modifiable maternal lifestyle factors and periconception outcomes, a systematic search was conducted for relevant studies published from 1990 to February 2017 on Embase, Medline, Web of Science, Cochrane database, PubMed and Google Scholar. The initial search identified 6166 articles, of which 49 studies were eligible for inclusion...
October 26, 2018: Reproductive Biomedicine Online
Henrike E Peters, Roel Schats, Marieke O Verhoeven, Velja Mijatovic, Christianne J M de Groot, Joanna L Sandberg, Immelie P Peeters, Cornelis B Lambalk
RESEARCH QUESTION: What are the reproductive and obstetric outcomes of the gestational surrogacy treatment in the Netherlands? DESIGN: This retrospective cohort study reports all data of gestational surrogacy treatment in the VU University Medical Centre over a period of 10 years. Data was collected from 60 intended parents and 63 gestational carriers, including reproductive and obstetric outcomes. RESULTS: All intended mothers had a medical indication for gestational surrogacy and used autologous oocytes, and semen of the intended father...
October 26, 2018: Reproductive Biomedicine Online
Nicolas Gatimel, Jessika Moreau, François Isus, Nathalie Moinard, Jean Parinaud, Roger D Leandri
RESEARCH QUESTION: Anti-sperm antibodies (ASA) have been shown to reduce male fertility but consensus about the precise situations in which tests should be carried out are lacking. In infertility investigations, should the mixed antiglobulin reaction (MAR) test be a first-line test? Should it be carried out systematically before assisted reproductive technology (ART)? What are the risk factors for ASA? DESIGN: All infertile patients (n = 1364) were tested with SpermMar (modified MAR test) between July 2013 and June 2017...
October 22, 2018: Reproductive Biomedicine Online
Miguel Gallardo, Fernanda Paulini, Ariadna Corral, Marcin Balcerzyk, Carolina M Lucci, Jérôme Ambroise, Marta Merola, Laura Fernandez-Maza, Rámon Risco, Marie-Madeleine Dolmans, Christiani A Amorim
RESEARCH QUESTION: Could a modification in the ovarian tissue freezing protocol improve follicle survival after cryopreservation and xenotransplantation? DESIGN: Ovarian tissue was used from 13 adult patients, frozen either with our original protocol, or a modified version involving a higher concentration of dimethyl sulphoxide (DMSO), larger volume of cryopreservation solution and lower seeding temperature. After thawing, the ovarian fragments were xenotransplanted to six mice with severe combined immunodeficiency (SCID) for 3 weeks...
October 22, 2018: Reproductive Biomedicine Online
Hester Pastoor, Reinier Timman, Cora de Klerk, Wichor M Bramer, Ellen Tm Laan, Joop Se Laven
We present the first systematic review and meta-analysis of sexual function in women with polycystic ovary syndrome (PCOS) compared with women without PCOS. Data on this topic are limited and often contradicting. Sexual function is influenced by endocrine, mental and social factors, which are often compromised in women with PCOS. The main outcome measures were validated sexual function questionnaires and visual analogue scales (VAS). We identified and assessed 1925 original articles; 18 articles were included...
October 19, 2018: Reproductive Biomedicine Online
J Giles, M Cruz, C González-Ravina, C Caligara, N Prados, J C Martínez, V Vergara, A Requena
RESEARCH QUESTION: Can predictors of twin and high-order multiple pregnancy among women with multiple cycles of ovarian stimulation intrauterine insemination (IUI) be identified? DESIGN: Retrospective cohort study of IUI cycles carried out between January 2014 and December 2015 in a private clinic in Spain. The 4879 women and 6552 cycles analysed in this study include single IUI with ovarian stimulation using recombinant FSH. RESULTS: Number of follicles and follicle size were the only factors with a significant effect (P < 0...
October 11, 2018: Reproductive Biomedicine Online
Fernando Zegers-Hochschild, Juan Enrique Schwarze, Javier Crosby, Carolina Musri, Maria Teresa Urbina
RESEARCH QUESTION: What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) performed in Latin American countries during 2015, and what were the regional trends? DESIGN: Retrospective collection of multinational data on assisted reproduction techniques (IVF and intracytoplasmic sperm injection [ICSI], frozen embryo transfer, oocyte donation, preimplantation genetic testing and fertility preservation), from 175 institutions in 15 Latin American countries...
October 6, 2018: Reproductive Biomedicine Online
Christoph Cirkel, Inke R König, Askan Schultze-Mosgau, Elmar Beck, Kay Neumann, Georg Griesinger
RESEARCH QUESTION: What is the association between assisted reproductive technologies and human sex ratio as a proportion of male offspring at birth. DESIGN: A total of 59,628 singleton deliveries resulting from IVF, intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI) or ovulation induction from 101 IVF clinics in Germany, that had been documented in a national German IVF registry, were analysed. Sex ratio after assisted reproductive technology was also compared with the sex ratio reported in the birth records of the German Federal Statistical Office...
October 6, 2018: Reproductive Biomedicine Online
Caroline Ogilvie, Susan Bint
No abstract text is available yet for this article.
October 6, 2018: Reproductive Biomedicine Online
Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter Humaidan
RESEARCH QUESTION: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen-thawed embryo transfer (HRT-FET) cycles? DESIGN: A cohort study of 244 HRT-FET cycles from a Danish public fertility centre. Data from patients undergoing HRT-FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in HRT cycles of autologous embryos frozen on day 5 or 6. Endometrial preparation was performed using 6 mg oestradiol valerate daily from the second day of the cycle followed by vaginal micronized progesterone (90 mg/8 h)...
October 6, 2018: Reproductive Biomedicine Online
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