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Reproductive Biomedicine Online

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https://www.readbyqxmd.com/read/28434652/multifetal-reduction-of-triplets-to-twins-compared-with-non-reduced-twins-a-meta-analysis
#1
Yaniv Zipori, Jigal Haas, Howard Berger, Eran Barzilay
The current systematic review and meta-analysis evaluates the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction (MPR) compared with non-reduced twins. We considered all studies comparing perinatal outcomes of twin pregnancies following MPR to non-reduced twin pregnancies. Our search yielded 639 publications, of which 91 were assessed for eligibility. A total of 22 studies met our inclusion criteria. Overall, fetal reduction of triplets to twins resulted in comparable perinatal outcomes to non-reduced twins with regards to gestational age and birthweight at delivery, pregnancy loss prior to 24 weeks, as well as the development of gestational diabetes and hypertensive disorders of pregnancy...
April 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28416291/cumulative-live-birth-rate-after-gnrh-agonist-trigger-and-elective-cryopreservation-of-all-embryos-in-high-responders
#2
Veljko Vlaisavljević, Borut Kovačič, Jure Knez
Elective embryo cryopreservation after using gonadotrophin-releasing hormone (GnRH) antagonist protocols and GnRH agonist triggering is becoming an increasingly important part of medically assisted reproduction. We designed a single-centre retrospective study to assess the cumulative probability of achieving a live birth through consecutive transfers of vitrified-warmed blastocysts after elective embryo cryopreservation in high-responding patients. Hence, 123 women identified to be at high risk for developing ovarian hyperstimulation syndrome were included...
April 7, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28427857/vitrified-warmed-single-embryo-transfers-may-be-associated-with-increased-maternal-complications-compared-with-fresh-single-embryo-transfers
#3
Tal Shavit, Galia Oron, Son Weon-Young, Hananel Holzer, Togas Tulandi
Cryopreservation of embryos allows single-embryo transfer and storage of supernumerary embryos, maximizing cumulative pregnancy rates. The purpose of this retrospective cohort study was to compare pregnancy outcome in singletons born after fresh or vitrified-warmed single blastocyst transfer (SBT). Singleton live births resulting from SBT of fresh or vitrified-warmed embryos were compared. Primary outcomes were perinatal outcomes including small for gestational age (SGA), low birthweight, preterm deliveries (PTD), large for gestational age (LGA) and congenital malformations...
April 6, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28434653/a-revised-prediction-model-for-natural-conception
#4
Alexandra J Bensdorp, Jan Willem van der Steeg, Pieternel Steures, J Dik F Habbema, Peter G A Hompes, Patrick M M Bossuyt, Fulco van der Veen, Ben W J Mol, Marinus J C Eijkemans
One of the aims in reproductive medicine is to differentiate between couples that have favourable chances of conceiving naturally and those that do not. Since the development of the prediction model of Hunault, characteristics of the subfertile population have changed. The objective of this analysis was to assess whether additional predictors can refine the Hunault model and extend its applicability. Consecutive subfertile couples with unexplained and mild male subfertility presenting in fertility clinics were asked to participate in a prospective cohort study...
March 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28416168/non-invasive-preimplantation-genetic-screening-using-array-comparative-genomic-hybridization-on-spent-culture-media-a-proof-of-concept-pilot-study
#5
Michael Feichtinger, Enrico Vaccari, Luca Carli, Elisabeth Wallner, Ulrike Mädel, Katharina Figl, Simone Palini, Wilfried Feichtinger
The aim of this pilot study was to assess if array comparative genomic hybridization (aCGH), non-invasive preimplantation genetic screening (PGS) on blastocyst culture media is feasible. Therefore, aCGH analysis was carried out on 22 spent blastocyst culture media samples after polar body PGS because of advanced maternal age. All oocytes were fertilized by intracytoplasmic sperm injection and all embryos underwent assisted hatching. Concordance of polar body analysis and culture media genetic results was assessed...
March 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28431828/clinical-use-of-monopronucleated-zygotes-following-blastocyst-culture-and-preimplantation-genetic-screening-including-verification-of-biparental-chromosome-inheritance
#6
Cara K Bradley, Maria Traversa, Natalie Hobson, Alison J Gee, Steven J McArthur
In assisted reproduction, embryos derived from monopronucleated (1PN) zygotes are considered abnormal and unsuitable for clinical use. Outcomes of 1PN-derived embryos designated for preimplantation genetic screening (PGS) were analysed. These embryos, especially from intracytoplasmic sperm injection (ICSI), were found to have a low developmental potential; 1PN and 2PN day 5 blastocyst development for IVF was 14.8% versus 36.4% (P < 0.0001), and for ICSI, 6.6% versus 34.0% (P < 0.0001), respectively. With the use of comparative genomic hybridization or next-generation sequencing, PGS was successfully carried out for 74 IVF and 32 ICSI 1PN-derived blastocysts, revealing adjusted abnormality rates of 39...
March 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28396044/predictive-factors-influencing-pregnancy-rates-after-intrauterine-insemination-with-frozen-donor-semen-a-prospective-cohort-study
#7
Annelies Thijssen, An Creemers, Wim Van der Elst, Eva Creemers, Eva Vandormael, Nathalie Dhont, Willem Ombelet
The extent to which certain parameters can influence pregnancy rates after intrauterine insemination with frozen donor semen was examined prospectively. Between July 2011 and September 2015, 402 women received 1264 IUI cycles with frozen donor semen in a tertiary referral infertility centre. A case report form was used to collect data prospectively. The primary outcome measure was clinical pregnancy rate (CPR), confirmed by detection of a gestational sac and fetal heartbeat using ultrasonography at 7-8 weeks of gestation...
March 23, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28410957/fetal-alpha-5-reductase-val89leu-mutation-is-associated-with-late-miscarriage
#8
Beatriz Pérez-Nevot, Jose-Luis Royo, Miriam Cortés, Ana M Lendínez, Arturo Reyes-Palomares, Ana-José Jiménez, Maximiliano Ruiz-Galdón, Armando Reyes-Engel
The present study was undertaken to determine the role of different polymorphisms affecting the testosterone/oestrogen pathway in miscarriage. Alpha 5-reductase (SRD5A2) rs523349 and rs9282858, cytochrome P450 aromatase (CYP19A1) rs4646, rs10046 and rs2236722 and oestrogen receptor (ESR1) rs9340799, rs2234693 and rs6932902 polymorphisms were selected. The case group consisted of 94 samples of formalin-fixed and paraffin-embedded fetal tissue from a miscarriage at ≤24 weeks. The control group comprised a population of 331 young healthy subjects...
March 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28372893/polycystic-ovary-syndrome-analysis-of-the-global-research-architecture-using-density-equalizing-mapping
#9
Dörthe Brüggmann, Lea Berges, Doris Klingelhöfer, Jan Bauer, Michael Bendels, Frank Louwen, Jenny Jaque, David A Groneberg
Polycystic ovary syndrome (PCOS) is the most common cause of female infertility worldwide. Although the related research output is constantly growing, no detailed global map of the scientific architecture has so far been created encompassing quantitative, qualitative, socioeconomic and gender aspects. We used the NewQIS platform to assess all PCOS-related publications indexed between 1900 and 2014 in the Web of Science, and applied density equalizing mapping projections, scientometric techniques and economic benchmarking procedures...
March 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28372892/ovarian-tissue-cryopreservation-in-female-to-male-transgender-people-insights-into-ovarian-histology-and-physiology-after-prolonged-androgen-treatment
#10
Chloë De Roo, Sylvie Lierman, Kelly Tilleman, Karen Peynshaert, Kevin Braeckmans, Mirte Caanen, Cornelius B Lambalk, Steven Weyers, Guy T'Sjoen, Ria Cornelissen, Petra De Sutter
Female-to-male transgender people (trans men) are faced with the risk of losing their reproductive potential owing to gender-affirming hormone treatment and genital reconstructive surgery. This observational, prospective cohort study investigates the effect of prolonged androgen therapy on their ovarian histology and fertility preservation perspectives. Hormone serum levels, ovarian histology and cumulus-oocyte complexes (COC) of 40 transsexual men were analysed at the moment of hysterectomy with bilateral oophorectomy in the context of genital reconstructive surgery after testosterone treatment (58...
March 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28366519/live-birth-rates-in-various-subgroups-of-poor-ovarian-responders-fulfilling-the-bologna-criteria
#11
Gurkan Bozdag, Mehtap Polat, Irem Yarali, Hakan Yarali
The European Society of Human Reproduction and Embryology published Bologna criteria to generate a definition of poor ovarian responders (PORs). However, there are few data on whether PORs are homogenous for ovarian response or live birth rates (LBRs). In this retrospective study, 821 patients fulfilling Bologna criteria and undergoing intracytoplasmic sperm injection were stratified into four groups: Group A: female age ≥40 with a previous poor response (cycle cancelled or ≤3 oocytes) (105 patients, 123 cycles); Group B: female age ≥40 with an antral follicle count (AFC) < 7 (159 patients, 253 cycles); Group C: AFC <7 with a previous poor response (350 patients, 575 cycles); and Group D: female age ≥40 with an AFC <7 and previous poor response (207 patients, 306 cycles)...
March 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28365199/outcomes-of-immature-oocytes-collected-from-ovarian-tissue-for-cryopreservation-in-adult-and-prepubertal-patients
#12
Giovanna Fasano, Julie Dechène, Raffaella Antonacci, Jamila Biramane, Anne-Sophie Vannin, Anne Van Langendonckt, Fabienne Devreker, Isabelle Demeestere
The efficiency of oocyte in-vitro maturation (IVM) and vitrification procedures after ex-vivo collection from ovarian tissue were assessed according to patient age, number of retrieved oocytes and tissue transport conditions. The combined procedure was performed in 136 patients: 130 adults (mean 27.6 ± 5.6 years) and six prepubertal girls (mean 8.7 ± 2.3 years). A higher mean number of oocytes were collected in girls compared with adults (11.5 ± 8.0 versus 3.8 ± 4.2, respectively, P < 0.001) but the percentage of degenerated oocytes was significantly higher in girls (35...
March 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28363462/neurodevelopmental-and-cardiometabolic-outcome-in-4-year-old-twins-and-singletons-born-after-ivf
#13
Derk Kuiper, Anne Bennema, Sacha la Bastide-van Gemert, Jorien Seggers, Pamela Schendelaar, Maaike Haadsma, Annemieke Hoek, Maas-Jan Heineman, Mijna Hadders-Algra
This prospective cohort study evaluated whether the cognitive development, neurological condition, anthropometrics and blood pressure of 4-year-old IVF twins differed from those of 4-year-old IVF singletons; 103 IVF singletons and 48 IVF twins born after conventional IVF treatment were included. Primary outcome was total intelligence quotient (IQ). Secondary outcomes were minor neurological dysfunction, anthropometrics and blood pressure. Unadjusted analyses found that the total IQ score of twins was lower than that of singletons, with a mean difference of -5...
March 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28363463/dietary-patterns-and-the-phenotype-of-polycystic-ovary-syndrome-the-chance-of-ongoing-pregnancy
#14
Nicole A Huijgen, Yvonne V Louwers, Sten P Willemsen, Jeanne H M de Vries, Régine P M Steegers-Theunissen, Joop S E Laven
Polycystic ovary syndrome (PCOS) is generally considered a complex disorder caused by interactions between genetic and environmental factors. In a sub-cohort of women with PCOS visiting the preconception outpatient clinic of a tertiary hospital with follow-up in a periconception cohort, we identified specific dietary patterns and adherence in patients with PCOS with and without hyperandrogenism and the chance of ongoing pregnancy. Food frequency questionnaires were available from 55 patients diagnosed with PCOS during follow-up in routine clinical practice, including 25 with hyperandrogenism and 30 without hyperandrogenism...
March 16, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28341386/follicular-output-rate-can-predict-clinical-pregnancy-in-women-with-unexplained-infertility-undergoing-ivf-icsi-a-prospective-cohort-study
#15
A Hassan, M Kotb, A AwadAllah, A Wahba, N Shehata
This study aimed to determine whether follicular output rate (FORT) can predict the clinical pregnancy rate in women with unexplained infertility undergoing IVF/ICSI. This was a prospective study conducted at Dar El Teb subfertility centre in Cairo between June 2014 and July 2016. A total of 303 women with unexplained infertility, who were undergoing IVF/ICSI, were divided into three groups according to FORT tertile values. FORT was calculated as pre-ovulatory follicle count/antral follicle count × 100. There was a progressive and significant increase from the low to the high FORT groups in the clinical pregnancy rate (29...
March 16, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28366518/economic-impact-of-ovarian-stimulation-with-corifollitropin-alfa-versus-conventional-daily-gonadotropins-in-oocyte-donors-a-randomized-study
#16
María Cruz, Pilar Alamá, Manuel Muñoz, Diana Collado, Carlos Blanes, Enrique Solbes, Antonio Requena
Assisted reproductive technologies are well-established treatments for many types of subfertility representing substantial economic and healthcare implications for patients, healthcare providers and society as a whole. In order to optimize outcomes according to the type of gonadotrophins within an oocyte donor programme, we performed an economic evaluation based on data collected in a multicentre, prospective, randomized study within three private clinics belonging to the IVI Group. Results showed no relevant between-group differences in the clinical variables...
March 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28336163/a-meta-analysis-of-the-impact-of-human-leukocyte-antigen-g-on-the-outcomes-of-ivf-icsi
#17
Ziru Niu, Liangyi Wang, Ronald T K Pang, Yifan Guo, William S B Yeung, Yuanqing Yao
This analysis was performed to determine whether the presence of soluble human leukocyte antigen-G (sHLA-G) in embryo culture medium is predictive of clinical outcomes in IVF treatment. The outcomes of implantation, clinical pregnancy, multiple pregnancy and miscarriage, between groups with and without sHLA-G in embryo culture media, were analysed. Fifteen studies with a total of 6170 cases were included. Ten of them were prospective studies while five were retrospective studies. Embryo culture media with sHLA-G were associated with significantly higher implantation rate and clinical pregnancy rate when compared with those without; the odd ratios (ORs) were 2...
March 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28336162/meiotic-segregation-analyses-of-reciprocal-translocations-in-spermatozoa-and-embryos-no-support-for-predictive-value-regarding-pgd-outcome
#18
Katarina Haapaniemi Kouru, Helena Malmgren, Irene White, Ana Rodriguez Sanchez, Elisabeth Syk Lundberg
Translocation heterozygotes have an increased risk of producing gametes with unbalanced chromosome content. This often leads to reproductive problems such as infertility, repeated miscarriages or birth of an affected child. To increase the chances of having a healthy live-born child, translocation heterozygotes often opt for preimplantation genetic diagnosis (PGD). The aim of this study was to investigate whether there is a correlation between chromosome segregation in spermatozoa from translocation heterozygotes and the number of balanced embryos produced during PGD that may be used to predict the PGD outcome...
March 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28314652/corrigendum-to-hysteroscopy-prior-to-a-first-ivf-treatment-cycle-the-need-for-well-performed-rct-reproductive-biomedicine-online-29-2014-142-142
#19
Janine G Smit, Helen L Torrance, Frank Jm Broekmans, Ben-Willem Mol
No abstract text is available yet for this article.
March 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28285952/ovarian-response-to-150%C3%A2-%C3%A2%C2%B5g-corifollitropin-alfa-in-a-gnrh-antagonist-multiple-dose-protocol-a-prospective-cohort-study
#20
Tamara Lerman, Marion Depenbusch, Askan Schultze-Mosgau, Soeren von Otte, Markus Scheinhardt, Inke Koenig, Axel Kamischke, Milan Macek, Arne Schwennicke, Sabine Segerer, Georg Griesinger
The incidence of low (<6 oocytes) and high (>18 oocytes) ovarian response to 150 µg corifollitropin alfa in relation to anti-Müllerian hormone (AMH) and other biomarkers was studied in a multi-centre (n = 5), multi-national, prospective, investigator-initiated, observational cohort study. Infertile women (n = 212), body weight >60 kg, underwent controlled ovarian stimulation in a gonadotrophin-releasing hormone-antagonist multiple-dose protocol. Demographic, sonographic and endocrine parameters were prospectively assessed on cycle day 2 or 3 of a spontaneous menstruation before the administration of 150 µg corifollitropin alfa...
March 2, 2017: Reproductive Biomedicine Online
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