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Reproductive Biomedicine Online

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https://www.readbyqxmd.com/read/28187961/a-retrospective-analysis-of-ovarian-stimulation-with-letrozole-in-women-undergoing-artificial-insemination-by-donor
#1
X J Sun, L Jiang, L C Ji, R Nie, H Chen, L Jin, G J Zhu, K Qian
The aim of this retrospective study was to determine the clinical pregnancy rate in women undergoing letrozole ovarian stimulation and artificial insemination by donor (AID). Between 2012 and 2015, 130 natural cycles, 939 letrozole cycles and 130 letrozole plus gonadotrophin cycles were conducted. Letrozole cycles were divided into three groups according to LH concentration on the day of HCG administration (LH <10 mIU/ml and follicle size ≥18 cm; LH ≤10 to <20 mIU/ml; and LH ≥20 mIU/ml). Pregnancy rates were 17...
January 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28169188/clinical-outcomes-after-ivf-or-icsi-using-human-blastocysts-derived-from-oocytes-containing-aggregates-of-smooth-endoplasmic-reticulum
#2
Fumiaki Itoi, Yukiko Asano, Masashi Shimizu, Rika Nagai, Kanako Saitou, Hiroyuki Honnma, Yasutaka Murata
In this study the clinical and neo-natal outcomes after transfer of blastocysts derived from oocytes containing aggregates of smooth endoplasmic reticulum (SER) were compared between IVF and intracytoplasmic sperm injection (ICSI) cycles. Clinical and neo-natal outcomes of blastocysts in cycles with at least one SER metaphase II oocyte (SER + MII; SER + cycles) did not significantly differ between the two insemination methods. When SER + MII were cultured to day 5/6, fertilization, embryo cleavage and blastocyst rates were not significantly different between IVF and ICSI cycles...
January 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28169189/ovarian-stimulation-protocols-for-ivf-is-more-better-than-less
#3
REVIEW
Michael M Alper, Bart C Fauser
Conventional ovarian stimulation protocols for IVF are designed to achieve maximum oocyte yields. Conventional protocols, however, are associated with patient discomfort, increased risk of ovarian hyperstimulation syndrome and higher costs. In recent years, mild stimulation protocols have risen in popularity. These protocols typically use lower doses (≤150 IU/day), shorter duration of exogenous gonadotrophins, or both, compared with conventional protocols, with the goal of limiting the number of retrieved oocytes to less than eight...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28162937/effect-of-progesterone-elevation-in-follicular-phase-of-ivf-cycles-on-the-endometrial-receptivity
#4
REVIEW
B Lawrenz, H M Fatemi
The premature rise of progesterone during the late follicular phase in stimulated IVF cycles is a frequent event, and emerging evidence shows that premature progesterone rise does negatively affect the outcome of assisted reproductive techniques. The effect of elevated peripheral progesterone levels in the late follicular phase seems to be on the endometrium and the window of implantation, which may lead to asynchrony between the endometrium and the developing embryo. In stimulated cycles, endometrial maturation is advanced on the day of oocyte retrieval, and patients with a progesterone level above 1...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28162936/obstetric-and-neo-natal-outcomes-of-icsi-cycles-using-pentoxifylline-to-identify-viable-spermatozoa-in-patients-with-immotile-spermatozoa
#5
Purificación Navas, Alessio Paffoni, Giulia Intra, Antonio González-Utor, Ana Clavero, Maria Carmen Gonzalvo, Rocío Díaz, Rocío Peña, Liliana Restelli, Edgardo Somigliana, Enrico Papaleo, Jose A Castilla, Paola Viganò
Pentoxifylline (PF) represents an effective tool in stimulating motility and identifying viable spermatozoa in intracytoplasmic sperm injection (ICSI) patients presenting exclusively with immotile spermatozoa. However, its use is not universally accepted for its possible detrimental effects on oocytes, embryos or newborns. To evaluate whether PF use may affect obstetrical/neo-natal outcomes, 102 patients achieving a clinical pregnancy after a PF-ICSI in four IVF units in Spain and Italy were followed up after delivery...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28189417/a-randomized-controlled-trial-investigating-the-use-of-a-predictive-nomogram-for-the-selection-of-the-fsh-starting-dose-in-ivf-icsi-cycles
#6
Adolfo Allegra, Angelo Marino, Aldo Volpes, Francesco Coffaro, Piero Scaglione, Salvatore Gullo, Antonio La Marca
The number of oocytes retrieved is a relevant intermediate outcome in women undergoing IVF/intracytoplasmic sperm injection (ICSI). This trial compared the efficiency of the selection of the FSH starting dose according to a nomogram based on multiple biomarkers (age, day 3 FSH, anti-Müllerian hormone) versus an age-based strategy. The primary outcome measure was the proportion of women with an optimal number of retrieved oocytes defined as 8-14. At their first IVF/ICSI cycle, 191 patients underwent a long gonadotrophin-releasing hormone agonist protocol and were randomized to receive a starting dose of recombinant (human) FSH, based on their age (150 IU if ≤35 years, 225 IU if >35 years) or based on the nomogram...
January 23, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28131495/multiple-dose-and-double-dose-versus-single-dose-administration-of-methotrexate-for-the-treatment-of-ectopic-pregnancy-a-systematic-review-and-meta-analysis
#7
REVIEW
Chun Yang, Jing Cai, Yuhong Geng, Ying Gao
In this systematic review and meta-analysis, the effectiveness and safety among different dosage of methotrexate protocols for the treatment of unruptured tubal ectopic pregnancy was evaluated. Six studies of randomized contorlled trials were identified through searches conducted on PubMed, Embase and Cochrane Library between January 1974 and March 2016. The overall success rate of multiple-dose protocol was similar to the single-dose protocol (RR 1.07, 95% CI 0.99 to 1.17, I(2) = 0%). The difference between double-dose and single-dose groups was not significant (RR 1...
January 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28126236/rs4265085-in-gper1-gene-increases-the-risk-for-unexplained-recurrent-spontaneous-abortion-in-dai-and-bai-ethnic-groups-in-china
#8
Liang Tang, Shui Zheng, Yan Wang, Fang Li, Meihua Bao, Jie Zeng, Ju Xiang, Huaiqing Luo, Jianming Li
Oestrogen receptors are implicated in the pathogenesis of recurrent spontaneous abortion (RSA). Non-genomic oestrogen responses can be mediated by GPER. The prevalence of polymorphisms in GPER1 gene in RSA was assessed in 747 Chinese women from Yunnan province (171 Bai, 258 Chinese Han, 234 Dai, 33 Achang and 51 Jingpo patients). Snapshot technology was used for genotyping the polymorphisms of the GPER1 gene. The rs4265085G was significantly increased in the Dai and Bai groups versus controls (Dai: P < 0...
January 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28109704/nicotine-promotes-vascular-endothelial-growth-factor-secretion-by-human-trophoblast-cells-under-hypoxic-conditions-and-improves-the-proliferation-and-tube-formation-capacity-of-human-umbilical-endothelial-cells
#9
Hongbo Zhao, Lanxiang Wu, Yahui Wang, Jiayi Zhou, Ruixia Li, Jiabing Zhou, Zehua Wang, Congjian Xu
Pre-eclampsia, characterized as defective uteroplacental vascularization, remains the major cause of maternal and fetal mortality and morbidity. Previous epidemiological studies demonstrated that cigarette smoking reduced the risk of pre-eclampsia. However, the molecular mechanism remains elusive. In the present study, it is demonstrated that a low dose of nicotine decreased soluble vascular endothelial growth factor receptor 1 (sFlt1) secretion in human trophoblast cells under hypoxic conditions. Nicotine was then observed to promote vascular endothelial growth factor (VEGF) secretion by reducing sFlt1 secretion and increasing VEGF mRNA transcription...
January 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28129970/counselling-considerations-for-chromosomal-mosaicism-detected-by-preimplantation-genetic-screening
#10
Andria G Besser, Emily L Mounts
The evolution of preimplantation genetic screening (PGS) for aneuploidy to blastocyst biopsy and more sensitive 24-chromosome screening techniques has resulted in a new diagnostic category of PGS results: those classified as mosaic. This diagnosis presents significant challenges for clinicians in developing policies regarding transfer and storage of such embryos, as well as in providing genetic counselling for patients prior to and following PGS. Given the high frequency of mosaic PGS results and the wide range of possible associated outcomes, there is an urgent need to understand how to appropriately counsel patients regarding such embryos...
January 16, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28117222/the-insr-rs2059806-single-nucleotide-polymorphism-a-genetic-risk-factor-for-vascular-and-metabolic-disease-associates-with-pre-eclampsia
#11
Prabha H Andraweera, Kathryn L Gatford, Gustaaf A Dekker, Shalem Leemaqz, Rohan W Jayasekara, Vajira H W Dissanayake, Lesley McCowan, Claire T Roberts
Pre-eclampsia is a risk factor for later life vascular and metabolic diseases. This study postulates that this reflects a common genetic cause, and investigates whether the INSR rs2059806 single nucleotide polymorphism (SNP) (a risk factor for essential hypertension, type 2 diabetes and metabolic syndrome) is also associated with pre-eclampsia. The association of INSR rs2059806 with pre-eclampsia was tested in two cohorts - a Caucasian case control group (123 pre-eclamptic mother-father-baby trios and 1185 mother-father-baby trios from uncomplicated pregnancies) and an independent cohort of Sinhalese women (175 women with pre-eclampsia and 171 women with uncomplicated pregnancies)...
January 11, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28109703/investigation-of-anogenital-distance-as-a-diagnostic-tool-in-endometriosis
#12
Maria L Sánchez-Ferrer, Jaime Mendiola, Raquel Jiménez-Velázquez, Laura Cánovas-López, Shiana Corbalán-Biyang, Ana I Hernández-Peñalver, Ana Carmona-Barnosi, Ana B Maldonado-Cárceles, Maria T Prieto-Sánchez, Francisco Machado-Linde, Anibal Nieto, Alberto M Torres-Cantero
An association between anogenital distance (AGD) and endometriosis has been reported, suggesting that AGD may be a useful clinical tool in endometriosis. The predictive ability of AGD of women in discriminating presence and type of endometriosis was examined. A case-control study was conducted at the University Hospital 'Virgen de la Arrixaca', Murcia, Spain, between 2014 and 2015. A total of 114 participants diagnosed with endometriosis using ultrasound findings and 105 controls were recruited. Two AGD measurements were obtained: one from the anterior clitoral surface to the upper verge of the anus (AGDAC), and another one from the posterior fourchette to the upper verge of the anus (AGDAF)...
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28087350/corrigendum-to-pregnancy-derived-from-human-zygote-pronuclear-transfer-in-a-patient-who-had-arrested-embryos-after-ivf-reproductive-biomedicine-online-33-2016-529-533
#13
John Zhang, Guanglun Zhuang, Yong Zeng, Jamie Grifo, Carlo Acosta, Yimin Shu, Hui Liu
No abstract text is available yet for this article.
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28089077/the-changing-pattern-of-uterine-contractions-before-and-after-fresh-embryo-transfer-and-its-relation-to-clinical-outcome
#14
Cathy Hoi Sze Chung, Alice Wai Yee Wong, Carol Pui Shan Chan, Sotirios H Saravelos, Grace Wing Shan Kong, Lai Ping Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li
In this prospective cohort study of 286 women undergoing fresh embryo transfer after IVF, uterine contraction frequency and direction were measured before (-5 min), 5 min after (+5 min) and 60 min after (+60 min) embryo transfer. Mean ± SD uterine contraction frequency at -5 min was 1.8 ± 1.1 contractions per min, increasing significantly (P < 0.05) to 2.0 ± 1.1 at +5 min, and returning back to baseline 1.8 ± 1.1 at +60 min. At -5 min, the proportion of women the with retrograde, antegrade, indeterminate direction and absent contractions were 33%, 44%, 17% and 6%; at +5 min, 40%, 42%, 13% and 5%, and at +60 min, 42%, 38%, 14% and 6%...
December 23, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28040414/reproductive-outcomes-of-ivf-patients-with-unicornuate-uteri
#15
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Kevin Coetzee
In this retrospective observational study, the pregnancy, perinatal and obstetric outcomes of patients diagnosed with unicornuate uteri were compared with those of patients with normal uteri after undergoing intracytoplasmic sperm injection (ICSI) with fresh and cryopreserved embryo transfer. From a select population of 9676 infertile patients receiving IVF treatment, 75 (0.78%) were diagnosed with unicornuate uteri between January 2009 and December 2015. Fifty of them underwent ICSI treatment, with 90 fresh and cryopreserved embryo transfers...
December 23, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28041830/luteal-phase-hcg-support-for-unexplained-recurrent-pregnancy-loss-a-low-hanging-fruit
#16
Chelsea Fox, Denise Azores-Gococo, Linda Swart, Kristin Holoch, Ricardo F Savaris, Creighton E Likes, Paul B Miller, David A Forstein, Bruce A Lessey
Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies and accounts for only 1-5% of pregnancy failures. Treatment options for unexplained RPL (uRPL) are limited. Previous studies suggest a link between delayed implantation and pregnancy loss. Based on this, a timely signal for rescue of the corpus luteum (CL) using human chorionic gonadotrophin (HCG) could improve outcomes in women with uRPL. This retrospective cohort study included 98 subjects with uRPL: 45 underwent 135 monitored cycles without HCG support; and 53 underwent 142 cycles with a single mid-luteal HCG injection...
December 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28040412/management-of-endometrial-polyps-incidentally-diagnosed-during-ivf-a-case-control-study
#17
Jehn-Hsiahn Yang, Po-Kai Yang, Mei-Jou Chen, Shee-Uan Chen, Yu-Shih Yang
An endometrial polyp is a frequently encountered abnormality of the uterine cavity that may interfere with normal embryo implantation. In this case-control study, we enrolled 56 women in whom endometrial polyps were incidentally diagnosed by transvaginal ultrasound and office hysteroscopy during IVF (Group 1), and 112 age-matched IVF controls randomly selected from the same time period (group 2). Cryopreserved embryos were transferred in group 1 whereas fresh embryos were transferred in group 2, which is a limitation of the study...
December 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28065417/assisted-reproduction-technique-outcomes-for-fresh-versus-deferred-cryopreserved-day-2-embryo-transfer-a-retrospective-matched-cohort-study
#18
Mathilde Bourdon, Pietro Santulli, Vanessa Gayet, Chloé Maignien, Louis Marcellin, Khaled Pocate-Cheriet, Charles Chapron
Ovarian stimulation could adversely affect endometrial receptivity and consequently embryo implantation. One emerging strategy is the 'freeze-all' approach. Most studies have focused on blastocyst transfers, with limited research on day-2 deferred cryopreserved embryo transfers. In this large retrospective cohort study, outcomes were compared between day-2 fresh versus deferred cryopreserved embryo transfers. After matching by age and number of previous cycles, 325 cycles were included in the fresh group and 325 in the deferred cryopreserved embryo transfers group: no significant differences were found between groups in implantation (0...
December 19, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28063801/effect-of-mid-follicular-phase-recombinant-lh-versus-urinary-hcg-supplementation-in-poor-ovarian-responders-undergoing-ivf-a-prospective-double-blinded-randomized-study
#19
Sze Man Jennifer Mak, Wai Yee Wong, Hoi Sze Chung, Pui Wah Chung, Grace Wing Shan Kong, Tin Chiu Li, Lai Ping Cheung
Luteinizing hormone (LH) is crucial for the development of follicular growth and oocyte maturation, especially in the management of poor ovarian responders (PORs). This study presents the results of a prospective double-blinded randomized study to compare the effect of mid-follicular phase recombinant LH (rLH) supplementation with urinary human chorionic gonadotrophin (uHCG) supplementation when using a fixed gonadotrophin-releasing hormone (GnRH) antagonist protocol in IVF cycles. A total of 49 women with poor ovarian response (POR) according to the Bologna criteria were recruited...
December 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28041829/cryopreserved-embryo-transfer-adjacent-or-non-adjacent-to-failed-fresh-long-gnrh-agonist-protocol-ivf-cycle
#20
Alexander Volodarsky-Perel, Talia Eldar-Geva, Hananel E G Holzer, Oshrat Schonberger, Orna Reichman, Michael Gal
The optimal time to perform cryopreserved embryo transfer (CET) after a failed oocyte retrieval-embryo transfer (OR-ET) cycle is unknown. Similar clinical pregnancy rates were recently reported in immediate and delayed CET, performed after failed fresh OR-ET, in cycles with the gonadotrophin-releasing hormone (GnRH) antagonist protocol. This study compared outcomes of CET performed adjacently (<50 days, n = 67) and non-adjacently (≥50 to 120 days, n = 62) to the last OR-day of cycles with the GnRH agonist down-regulation protocol...
December 16, 2016: Reproductive Biomedicine Online
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