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Reproductive Biomedicine Online

P Ferrer Molina, C Calatayud Lliso, R Carreras Collado, M Muñoz García, M Díaz Bachiller, J Blanes Espí, M Checa
RESEARCH QUESTION: To determine whether the transdermal route is equal or superior to the oral route, when preparing the endometrium with oestrogens for embryo transfer. DESIGN: Prospective, randomized controlled trial; 140 patients randomized; the pills group followed a protocol with oestradiol valerate pills and the patches group followed a protocol with oestradiol hemihydrate patches. The primary variable was endometrial thickness on day 10 ± 1 of treatment...
September 29, 2018: Reproductive Biomedicine Online
Anna Garcia-Alix Grynnerup, Anette Lindhard, Steen Sørensen, Mette Ørskov, Kresten Rubeck Petersen, Lisbeth Buss Madsen, Fie Pilsgaard, Kristine Løssl, Anja Pinborg
RESEARCH QUESTION: Does salpingectomy for ectopic pregnancy affect the ovarian reserve measured by changes in pre- and post-operative levels of anti-Müllerian hormone (AMH)? DESIGN: This is a prospective observational multicentre study of 64 women treated with salpingectomy for an ectopic pregnancy. AMH was measured in serum samples collected at admission before salpingectomy and at follow-up (median time to follow-up [interquartile range] was 3 [3-4] months). Changes in serum AMH levels were investigated using Wilcoxon signed-rank test and the relationship between changes in AMH and age, time to follow-up, and pre-operative serum AMH level was investigated using linear regression analysis...
September 15, 2018: Reproductive Biomedicine Online
Oshrit Lebovitz, Jigal Haas, Kaitlyn E James, Daniel S Seidman, Raoul Orvieto, Ariel Hourvitz
RESEARCH QUESTION: What is the cumulative incidence of live birth (CLIB) for high-order consecutive IVF cycles, and which factors are associated with live birth of women aged ≥41 years using autologous oocytes? DESIGN: A retrospective cohort study including 146 patients aged 41 years to <44 years who started their first IVF cycle attempt using autologous oocytes, between January 2006 and December 2013. RESULTS: After 13 IVF cycles, CILB reached up to 33...
September 12, 2018: Reproductive Biomedicine Online
Jackie Mc Ferguson, David Pépin, Chinwe Duru, Paul Matejtschuk, Patricia K Donahoe, Chris J Burns
RESEARCH QUESTION: Is formulated and lyophilized, recombinant human Müllerian inhibiting substance, also known as anti-Müllerian hormone (AMH), suitable for the preparation of a WHO international standard to calibrate AMH immunoassays? DESIGN: The AMH content of a trial preparation, coded SS-581, was determined by five laboratories using seven immunoassay methods. Participants were requested to report the content of the preparation in terms of their method calibrators through the measurement of a minimum of five concentrations in the linear part of the dose-response curve...
September 5, 2018: Reproductive Biomedicine Online
Iñigo de Miguel Beriain, Begoña Sanz
In December 2017, Alain Pottage published an article denying the patentability of a technique called Time-Lapse Monitoring (TLM). His argument was that this procedure, like all other embryo selection procedures, fails to respect human dignity. Here, we argue that this statement is mistaken because assisted reproductive technologies (ART) require a scarce resource, namely a woman's uterus in the right physiological condition. Therefore, embryo selection using TLM is entirely appropriate, as it is not possible to guarantee that all of them will have access to the environment they need to develop...
August 30, 2018: Reproductive Biomedicine Online
Jan Tesarik Md PhD
No abstract text is available yet for this article.
August 29, 2018: Reproductive Biomedicine Online
Shuang Zhou, Dehua Cheng, Qi Ouyang, Pingyuan Xie, Changfu Lu, Fei Gong, Liang Hu, Yueqiu Tan, Guangxiu Lu, Ge Lin
RESEARCH QUESTION: What is the prevalence and authenticity of de-novo segmental aneuploidies (>16 Mb) detected by next-generation sequencing (NGS) in human preimplantation blastocysts? DESIGN: Between April 2013 and June 2016, 5735 blastocysts from 1854 couples (average age 33.11 ± 5.65 years) underwent preimplantation genetic testing for chromosomal structural rearrangement (PGT-SR) or for aneuploidy (PGT-A) using NGS on trophectoderm (TE) biopsy samples. The prevalence of de-novo segmental aneuploidy was calculated from these results...
August 29, 2018: Reproductive Biomedicine Online
Majid Tarahomi, Annemieke A de Melker, Madelon van Wely, Geert Hamer, Sjoerd Repping, Sebastiaan Mastenbroek
RESEARCH QUESTION: How stable is the pH of human preimplantation embryo culture media during IVF culture and is there variation in pH between batches of culture media? DESIGN: To evaluate pH stability, three batches of three culture media were incubated in triplicate without embryos (sham culture) at CO2 levels recommended by the manufacturers (5% or 6%) for 4 days. To evaluate differences in pH between batches, the pH of three batches of five culture media was measured in triplicate during 1 day of sham culture...
August 29, 2018: Reproductive Biomedicine Online
Liangshan Mu, Yue Zhao, Rong Li, Yuchen Lai, Jie Qiao
RESEARCH QUESTION: The aim was to investigate the metabolic profiles of women with normal weight but central obesity in polycystic ovary syndrome (PCOS). DESIGN: In total, 727 women with PCOS from a large-scale epidemiological survey were included. Diagnosis of PCOS was based on Rotterdam criteria. Subjects were categorized into four subgroups: (i) normal weight non-central obesity (NWNCO): body mass index (BMI) ≤18.5 kg/m2 to <25 kg/m2 and waist-to-hip ratio (WHR) <0...
August 29, 2018: Reproductive Biomedicine Online
Li Jin, Qian Yang, Chengliang Zhou, Lanxin Liu, Huihui Wang, Min Hou, Yimei Wu, Fengtao Shi, Jianzhong Sheng, Hefeng Huang
RESEARCH QUESTION: What is the expression pattern of long non-coding RNAs (lncRNA) in ovarian granulosa cells of women with polycystic ovary syndrome (PCOS) with or without hyperandrogenism? DESIGN: Microarray screening of lncRNA was conducted in ovarian granulosa cells collected from women with PCOS with hyperandrogenism (PCOS-T) or without hyperandrogenism (PCOS-N) and control participants, with four samples in each group. This was followed by hierarchy clustering, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses...
August 29, 2018: Reproductive Biomedicine Online
Alain Pottage
No abstract text is available yet for this article.
August 28, 2018: Reproductive Biomedicine Online
Juan Ji, Miaofei Xu, Rong Wang, Ying Wang, Yufeng Qin, Lei Li, Hongxiang Zheng, Shuping Yang, Shilin Li, Dengshun Miao, Li Jin, Lin Zhou, Xiufeng Ling, Yankai Xia, Chuncheng Lu, Xinru Wang
RESEARCH QUESTION: What is the role of mitochondrial DNA (mtDNA) in the pathogenesis of non-obstructive azoospermia (NOA)? DESIGN: mtDNA genome sequencing followed by an independent population validation were performed in 628 NOA cases and 584 healthy controls. Antioxidant capacity of serum was evaluated in 54 randomly selected cases out of 536 and 49 out of 489 controls. RESULTS: In the screening stage, 13 mtDNA haplogroups (hg) were ascertained, and 10 susceptible variants were observed...
August 23, 2018: Reproductive Biomedicine Online
Elena Labarta, Diego Marin, José Remohí, Ernesto Bosch
RESEARCH QUESTION: Is minimal ovarian stimulation (MOS) as effective as conventional ovarian stimulation (COS) in ovarian response and embryo quality in the same 46 poor-responder patients according to the Bologna criteria? DESIGN: An intra-patient comparison of patients undergoing both protocols. Ovaries were stimulated with either a gonadotrophin-releasing hormone antagonist protocol and a combination of recombinant FSH and highly purified human menotrophin (HP-HMG) daily (COS), or with the use of clomiphene citrate 50 mg daily and 150 IU of HP-HMG or recombinant FSH every other day from simulation day 4 (MOS)...
August 23, 2018: Reproductive Biomedicine Online
Zehong Zhou, Lixue Chen, Hongping Wu, Danni Zheng, Rong Li, Ben Willem Mol, Jie Qiao
RESEARCH QUESTION: Why are comprehensive and detailed reports of local or national utilization outcomes of assisted reproductive technology (ART) lacking in China? DESIGN: Retrospective collection of data on intrauterine insemination (IUI) and IVF and intracytoplasmic sperm injection (ICSI) in Beijing, including all 12 registered institutions with cycles, started between 1 January 2013 and 31 December 2015. RESULTS: Clinical pregnancy rates (CPR) per aspiration and fresh embryo transfer were 39...
August 22, 2018: Reproductive Biomedicine Online
Gill Lockwood, Bart Cjm Fauser
No abstract text is available yet for this article.
August 21, 2018: Reproductive Biomedicine Online
Santiago Munné
At the recent 2018 PGDIS congress, a review of randomized controlled trials of preimplantation genetic testing for aneuploidies (PGT-A) showed improved ongoing pregnancy rates per transfer in experienced centres and in women aged 35 years and older. Young women produce 40% abnormal embryos (20-60% range), but not all centres see a selection advantage; this indicates the need for more emphasis in improving biopsy and case management. Some chromosome abnormalities are iatrogenic; PGT-A could, therefore, be used as assisted reproductive technology (ART) quality control...
August 20, 2018: Reproductive Biomedicine Online
Giovanna Sighinolfi, Sesh Kamal Sunkara, Antonio La Marca
The theory of a multicyclic development of follicles during the menstrual cycle prompted new approaches to ovarian stimulation, such as starting gonadotrophins for ovarian stimulation at any time during the menstrual cycle or using double stimulation during it, with stimulation in both the follicular and luteal phases. Because of the asynchrony between endometrial receptivity and embryo development with a 'non-conventional start' stimulation, all the oocytes/embryos are generally cryopreserved and transferred subsequently...
August 11, 2018: Reproductive Biomedicine Online
Beatrice Chung Fat King Brunet, Jiandong Shen, Lingbo Cai, Jiazhi Xie, Yugui Cui, Jiayin Liu, Wei Wu
RESEARCH QUESTION: Can preimplantation genetic testing (PGT) with next-generation sequencing (NGS) increase the chance of achieving a balanced euploid pregnancy in complex chromosome rearrangement (CCR) carriers? DESIGN: Six couples underwent PGT at the Clinical Centre of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University. The CCR carriers in the six couples were: Case A: 46,XY,t(1;4;11)(p31;p16;q22); Case B: 46,XY,t(3;13;5)(p14;q21;p14); Case C: 46,XX,t(6;11;21)(q21;q21;q13); Case D: 46,XX,inv(9)(p12; q13),t(13;15)(q14;q24); Case E: 46,XX,inv(9)(p12;q13),t(7;9)(q22;p22); and Case F: 46,XX,t(2;7)(q21;q36),t(2;4)(p10;q10),t(2;4)(q15;q10)...
September 2018: Reproductive Biomedicine Online
Jacques Donnez, Marie-Madeleine Dolmans
At the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30-40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen-thawed ovarian tissue is able to restore long-term ovarian endocrine function that can persist for more than 7 years (12 years if the procedure is repeated)...
September 2018: Reproductive Biomedicine Online
Alberto Vaiarelli, Danilo Cimadomo, Pasquale Patrizio, Roberta Venturella, Giovanna Orlando, Daria Soscia, Adriano Giancani, Antonio Capalbo, Laura Rienzi, Filippo Maria Ubaldi
RESEARCH QUESTION: Biochemical pregnancy loss (BPL), defined as serum beta-human chorionic gonadotropin levels ≥50 IU/l in at least two pregnancy tests, not associated with any ultrasonographical evidence of pregnancy, is often attributed to chromosomal abnormalities; however, no hard evidence exists to support this hypothesis. Are any IVF cycle parameters associated with the occurrence of a BPL? DESIGN: Retrospective study aimed at evaluating the effect of embryo developmental stage at transfer and chromosomal assessment on the BPL rate in IVF after frozen embryo transfer (FET)...
September 2018: Reproductive Biomedicine Online
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