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Reproductive Biomedicine Online

A Arav, Z Gavish, A Elami, Y Natan, A Revel, S Silber, R G Gosden, P Patrizio
No abstract text is available yet for this article.
September 5, 2017: Reproductive Biomedicine Online
Samuel Kofi Arhin, Yu Zhao, XiaoSheng Lu, Mandika Chetry, JieQiang Lu
There is accumulating evidence on the importance of micronutrients in improving fertility in couples undergoing IVF therapy. Despite this, studies reporting the relevant clinical outcomes of IVF, such as pregnancy and live birth rates, are very scarce. This review aimed to systematically summarize clinical evidence on the effect of micronutrients on primary outcome parameters of IVF treatment. The literature was searched up to February 2017 through Embase and PubMed databases for relevant studies. The quality of eligible studies was assessed with the Downs and Black checklist...
August 30, 2017: Reproductive Biomedicine Online
Stephen C Collins, Esther Chan
Ethical concerns over treatments for infertility can discourage patients from pursuing fertility healthcare. This study aims to evaluate the sociocultural factors that influence the ethical views of reproductive-aged women regarding various fertility treatments. A publicly available cross-sectional survey of 4792 nationally representative US women aged 25-52 years was analysed to identify the frequency of ethical concerns over such interventions. Concerns were most common for treatments that increase the chance of twins (54%), followed by third-party reproductive strategies (48-51%), IVF (30%) and partner insemination (14%)...
August 25, 2017: Reproductive Biomedicine Online
Ragaa Mansour, Yahia El-Faissal, Ahmed Kamel, Omnia Kamal, Gamal Aboulserour, Mohamed Aboulghar, Ibrahim Fahmy
This prospective case-control study aimed to test the presence of insulin resistance (IR) in men with unexplained infertility. We included two groups: the study group including 160 infertile men with unexplained oligozoospermia (sperm count <10 × 10(6)/ml) and normal hormonal profile, and the control group of 79 men with proven fertility within the preceding year. A fasting blood test measured IR, FSH, LH, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides. Insulin level was significantly higher in the study group (13...
August 24, 2017: Reproductive Biomedicine Online
Christophe Blockeel, Panagiotis Drakopoulos, Nikolaos P Polyzos, Herman Tournaye, Juan Antonio García-Velasco
Peer review has been the main form of appraisal of scientific knowledge for over a century. In essence, this process involves the evaluation of a scientific finding by independent experts prior to its dissemination to the scientific community, in an attempt to ensure that both the research and conclusions meet the necessary standards regarding quality, accuracy, relevance and novelty. However, although 'peer review' is considered the current gold standard, it is far from perfect. A focus on the methodology of an article and reviewers' training are key messages for the scientific community...
August 24, 2017: Reproductive Biomedicine Online
Francisca Martínez, Alejandro Kava-Braverman, Elisabet Clúa, Ignacio Rodríguez, Sofia Gaggiotti Marre, Buenaventura Coroleu, Pedro N Barri
The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (LBR) were no different with increasing donor BMI (up to donor BMI ≤28 kg/m(2)). The odds of pregnancy did not vary with donor BMI. Compared with donor BMI quartile 1, OR 95% CI of clinical pregnancy was 1...
August 15, 2017: Reproductive Biomedicine Online
Yalcin Yavas
In assisted reproduction technique cycles using fresh autologous embryos, the pattern by which outcomes per started cycle (live birth and clinical pregnancy) and per clinical pregnancy (live birth and miscarriage) change with age was determined. A dataset was created with 488,351 cycles. Success rates changed with age following well-fitted, ∩-shaped curvilinear (quadratic, cubic, quartic) regressions. These rates increased steadily from age <24-28 years (P = 0.001; P = 0.02; P = 0.04; respectively) with positive slopes (P ≤ 0...
August 15, 2017: Reproductive Biomedicine Online
Samer Tannus, Yoni Cohen, Weon-Young Son, Tal Shavit, Michael-Haim Dahan
This retrospective cohort study aimed to identify predictive factors for live birth following blastocyst transfer in women aged 40-43, and to compare the cumulative live birth rate (LBR) following elective single blastocyst (eSBT) and double blastocyst (DBT) transfer. The study included 411 women who had fresh blastocyst transfers on day 5. In stepwise logistic regression, independent predictive factors for live birth were: transferring fully expanded blastocysts (Gardner stage ≥3) (odds ratio [OR] 3.5, 95% confidence interval [CI] 1...
August 10, 2017: Reproductive Biomedicine Online
Charlene Herbemont, Solmaz Sarandi, Jeremy Boujenah, Isabelle Cedrin-Durnerin, Nathalie Sermondade, Alexandre Vivot, Christophe Poncelet, Michael Grynberg, Christophe Sifer
Clinical outcomes of 291 day-5 blastocyst transfers carried out between January 2012 and March 2016 were retrospectively compared according to their quality at day 2 and 3. Inclusion criteria were female age younger than 37 years; first or second IVF and intracytoplasmic sperm injection cycle; quality of the transferred blastocyst: blastocoele B3 or higher; inner-cell-mass A/B; trophectoderm A/B; and known implantation outcome for each transferred blastocyst. Blastocysts were classified into good-quality and poor-quality embryo groups at day 2 and 3...
August 4, 2017: Reproductive Biomedicine Online
Marine Paci, Razan Elkhatib, Guy Longepied, Sylviane Hennebicq, Julien Bessonat, Blandine Courbière, Patrice Bourgeois, Nicolas Levy, Michael J Mitchell, Catherine Metzler-Guillemain
The aim of this study was to characterize the nuclear lamina (NL) and lamin chromatin-partners in spermatozoa from four DPY19L2-deleted globozoospermic patients. We tested for spermatid transcripts encoding lamins and their chromatin-partners emerin, LAP2α, BAF and BAF-L, by reverse transcriptase-PCR using spermatozoa RNA. We also determined the localization of lamin B1, BAF and BAF-L by immunofluorescent analysis of spermatozoa from all patients. In RNA from globozoospermic and control spermatozoa we detected transcripts encoding lamin B1, lamin B3, emerin, LAP2α and BAF-L, but not A-type lamins...
August 4, 2017: Reproductive Biomedicine Online
Julia Rehnitz, Diego D Alcoba, Ilma S Brum, Katrin Hinderhofer, Berthe Youness, Thomas Strowitzki, Peter H Vogt
Granulosa cells (GCs) play a major role in folliculogenesis and are crucial for oocyte maturation and growth. In these cells, the mTOR/AKT signalling pathway regulates early folliculogenesis by maintaining the dormancy of primordial follicles, while FSH induces their further differentiation and maturation. Because changes in number of CGG triplets in FMR1 exon 1 (below or beyond normal values of 26-34 triplets) affect ovarian reserve and pre-mutations containing >54 CGG triplets represent a known risk factor for premature ovarian insufficiency/failure, we investigated in the human GC model (COV434) how FMR1/FMRP and mTOR/AKT are expressed and potentially interact during GC proliferation...
August 4, 2017: Reproductive Biomedicine Online
(no author information available yet)
This proceedings report presents the outcomes from an international workshop supported by the European Society of Human Reproduction and Embryology (ESHRE) and Alpha Scientists in Reproductive Medicine, designed to establish consensus on definitions and recommended values for Indicators for the assisted reproductive technology (ART) laboratory. Minimum performance-level values ('competency') and aspirational ('benchmark') values were recommended for a total of 19 Indicators, including 12 Key Performance Indicators (KPIs), five Performance Indicators (PIs), and two Reference Indicators (RIs)...
August 4, 2017: Reproductive Biomedicine Online
Xihong Li, Yan Ouyang, Yan Yi, Ge Lin, Guangxiu Lu, Fei Gong
Unicornuate uteri are caused by non-development of one Müllerian duct. The objective of this study was to investigate pregnancy outcomes of singleton and/or twin pregnancies in women with unicornuate uterus after IVF-embryo transfer (IVF-ET). The study group comprised 238 patients with a unicornuate uterus and the control group 818 patients with normal uterus. Compared with pregnancies with normal uterine morphology, a unicornuate uterus was associated with an increased risk of early pregnancy loss [adjusted odds ratio (aOR) 1...
August 3, 2017: Reproductive Biomedicine Online
Michael von Wolff, Petra Stute, Markus Eisenhut, Ulrich Marti, Norman Bitterlich, Nick A Bersinger
Basic research into a possible link between serum and follicular fluid androgen concentrations to detemine whether androgen supplementation in low responders affects follicular endocrine milieu is still lacking. Ninety-seven women (aged 28-43 years) undergoing one natural IVF cycle without any hormone stimulation were analysed. Serum and follicular fluid were collected at the time of follicle aspiration, and the concentrations of LH, total testosterone, oestradiol, dehydroepiandrosterone and anti-Mullerian hormone (AMH) were determined...
August 2, 2017: Reproductive Biomedicine Online
Grace Wing Shan Kong, Jennifer Sze Man Mak, Tin Chiu Li
No abstract text is available yet for this article.
August 2, 2017: Reproductive Biomedicine Online
Itai Gat, Basheer AlKudmani, Karen Wong, Khaled Zohni, Noga Fuchs Weizman, Clifford Librach, Prati Sharma
Anti-Müllerian hormone (AMH) is a standard marker of ovarian reserve. Correlation between AMH and egg euploidy is controversial. We evaluated the association between AMH and blastocyst euploidy rate examined by pre-implantation genetic screening (PGS). This retrospective study was conducted at the CReATe Fertility Centre. We included single IVF cycles of 216 infertile couples, which resulted in 911 blastocysts subjected to array comparative genomic hybridization and evaluated IVF outcome after embryo transfer...
August 1, 2017: Reproductive Biomedicine Online
Dimitrios Mavrelos, Tom K Holland, Oliver O'Donovan, Mohamed Khalil, George Ploumpidis, Davor Jurkovic, Yakoub Khalaf
Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of infertility who attended for a 3D scan prior to IVF-ET. A total of 150/375 (40.0%, 95% confidence interval [CI] 35.2-45.0) women had clinical pregnancy. Women with any feature of adenomyosis had a lower clinical pregnancy rate (21/72 [29.2%, 95% CI 18.6-39.6] versus 129/303 [42...
July 29, 2017: Reproductive Biomedicine Online
Lu Luo, Fang Gu, Huying Jie, Chenhui Ding, Qiang Zhao, Qiong Wang, Canquan Zhou
The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed...
July 29, 2017: Reproductive Biomedicine Online
Jun Guo, T C Li, YuHuan Liu, EnLan Xia, Yu Xiao, FengQiong Zhou, Xue Yang
The aim of this prospective, randomized, controlled trial was to evaluate the efficacy of different doses of oestrogen treatment (2 mg and 6 mg daily) after hysteroscopic adhesiolysis in patients with moderate to severe adhesion according to the American Fertility Society (AFS) classification of intrauterine adhesions. A total of 121 patients were included in the final analysis. Fifty-nine patients received 2 mg oestrogen daily (low-dose group), and 62 received 6 mg oestrogen daily (high-dose group) for three cycles after surgery...
July 29, 2017: Reproductive Biomedicine Online
Emilia Richter, Wenhui Fang, Salvatore Longobardi, Thomas D'Hooghe
No abstract text is available yet for this article.
July 25, 2017: Reproductive Biomedicine Online
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