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Reproductive Biomedicine Online

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https://www.readbyqxmd.com/read/29673729/perinatal-outcomes-following-ivf-with-use-of-donor-versus-partner-sperm
#1
Mohan Shashikant Kamath, Belavendra Antonisamy, Hepsy Y Selliah, Antonio La Marca, Sesh Kamal Sunkara
It is a matter of interest whether pregnancies with the use of donor sperm are associated with a higher risk of adverse perinatal outcomes compared with partner sperm. Anonymized data were obtained from the Human Fertilization & Embryology Authority. Data from 1991 to 2011 involving a total of 95,787 singleton births (4523 with donor sperm and 91,264 with partner sperm) following fresh IVF/intracytoplasmic sperm injection (ICSI) were analysed to compare perinatal outcomes of preterm birth (PTB), low birthweight (LBW) and high birthweight (HBW)...
April 6, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29673731/duplication-of-sox9-associated-with-46-xx-ovotesticular-disorder-of-sex-development
#2
Berenice López-Hernández, Juan Pablo Méndez, Ramón Mauricio Coral-Vázquez, Jesús Benítez-Granados, Juan Carlos Zenteno, Vanessa Villegas-Ruiz, Raúl Calzada-León, Daniela Soderlund, Patricia Canto
RESEARCH QUESTION: The purpose of the present study was to investigate whether ten unrelated SRY-negative individuals with this sex differentiation disorder presented a double dose of SOX9 as the cause of their disease. DESIGN: Ten unrelated SRY-negative 46,XX ovotesticular disorder of sexual development (DSD) subjects were molecularly studied. Multiplex-ligation dependent probe amplification (MLPA) and quantitative real-time PCR analysis (qRT-PCR) for SOX9 were performed...
April 4, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29673730/early-oocyte-denudation-does-not-compromise-icsi-cycle-outcome-a-large-retrospective-cohort-study
#3
Osama Naji, Natalie Moska, Yaser Dajani, Awatuf El-Shirif, Hassan El-Ashkar, Mohamed Hosni, Mohamed Khalil, Yacoub Khalaf, Virginia Bolton, Tarek El-Toukhy
This retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were divided into two groups: group I (denudation within <2 h of oocyte retrieval, n = 1118) and group II (denudation 2-5 h after oocyte retrieval, n = 933). Univariate analysis by two-sample t-test or Mann-Whitney test was used, as appropriate...
April 4, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29628331/prediction-of-endometriosis-fertility-index-in-patients-with-endometriosis-associated-infertility-after-laparoscopic-treatment
#4
Xianghui Zhang, Dong Liu, Wei Huang, Qiushi Wang, Xue Feng, Jing Tan
The effect of endometriosis on fecundity is unclear. Although surgery plays a vital role in the treatment of related infertility, pregnancy outcomes after laparoscopy are poorly correlated with the currently used staging system. To address this, the Endometriosis Fertility Index (EFI) was developed. This retrospective study was designed to assess the predictive value of the EFI for patients with endometriosis-associated infertility. A total of 1325 patients with endometriosis-associated infertility were eligible for inclusion, 1097 of whom were successfully interviewed and 228 lost to follow-up (17...
March 27, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29625822/comparing-36-5%C3%A2-c-with-37%C3%A2-c-for-human-embryo-culture-a-prospective-randomized-controlled-trial
#5
Mohamed Fawzy, Mai Emad, Mostafa A Gad, Mohamed Sabry, Hesham Kasem, Manar Mahmoud, Mohamed A Bedaiwy
This prospective, double-blind, randomized controlled trial was designed to evaluate the efficacy of a culture temperature of 36.5°C versus 37°C on human embryo development in vitro. A total of 412 women undergoing IVF were randomized to two groups: the oocytes and embryos of the intervention group were cultured at 36.5°C; those of the control group were cultured at 37°C. Although no significant effect of culture temperature was observed on pregnancy or implantation rates, differences were found in embryo development...
March 27, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29622404/depression-and-state-anxiety-scores-during-assisted-reproductive-treatment-are-associated-with-outcome-a-meta-analysis
#6
REVIEW
Satvinder Purewal, Sarah C E Chapman, Olga B A van den Akker
This meta-analysis investigated whether state anxiety and depression scores during assisted reproductive technology (ART) treatment and changes in state anxiety and depression scores between baseline and during ART treatment are associated with treatment outcome. PubMed, PsycInfo, Embase, ScienceDirect, Web of Science and Scopus were searched and meta-analytic data analysed using random effects models to estimate standardized mean differences. Eleven studies (2202 patients) were included. Women who achieved pregnancy had significantly lower depression scores during treatment than women who did not become pregnant (-0...
March 23, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29606347/novel-mutations-in-genes-encoding-subcortical-maternal-complex-proteins-may-cause-human-embryonic-developmental-arrest
#7
Xueqian Wang, Di Song, Dmytro Mykytenko, Yanping Kuang, Qifeng Lv, Bin Li, Biaobang Chen, Xiaoyan Mao, Yao Xu, Valery Zukin, Pavlo Mazur, Jian Mu, Zheng Yan, Zhou Zhou, Qiaoli Li, Suying Liu, Li Jin, Lin He, Qing Sang, Zhaogui Sun, Xi Dong, Lei Wang
Successful human reproduction initiates from normal gamete formation, fertilization and early embryonic development. Abnormalities in any of these steps will lead to infertility. Many infertile patients undergo several failures of IVF and intracytoplasmic sperm injection (ICSI) cycles, and embryonic developmental arrest is a common phenotype in cases of recurrent failure of IVF/ICSI attempts. However, the genetic basis for this phenotype is poorly understood. The subcortical maternal complex (SCMC) genes play important roles during embryonic development, and using whole-exome sequencing novel biallelic mutations in the SCMC genes TLE6, PADI6 and KHDC3L were identified in four patients with embryonic developmental arrest...
March 21, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29631949/genome-wide-screening-for-smallest-regions-of-overlaps-in-cryptorchidism
#8
Kristian Urh, Tanja Kunej
Cryptorchidism is a urogenital abnormality associated with increased rates of testicular neoplasia and impaired spermatogenesis. The field is facing expansion of genomics data; however, it lacks protocols for biomarker prioritization. Identification of smallest regions of overlap (SRO) presents an approach for candidate gene identification but has not yet been systematically conducted in cryptorchidism. The aim of this study was to conduct a genome-wide screening for SRO (GW-SRO) associated with cryptorchidism development...
March 16, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29602730/response-the-applicable-scope-of-dual-trigger
#9
LETTER
Jie Zhang, Yanping Kuang
No abstract text is available yet for this article.
March 16, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29631950/response-impact-of-androgen-supplementation-on-the-follicular-endocrine-milieu-in-women-with-hypoandrogenism
#10
LETTER
Michael von Wolff, Petra Stute, Nick A Bersinger
No abstract text is available yet for this article.
March 15, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29627226/does-preimplantation-genetic-diagnosis-improve-reproductive-outcome-in-couples-with-recurrent-pregnancy-loss-owing-to-structural-chromosomal-rearrangement-a-systematic-review
#11
REVIEW
Mahmoud Iews, Justin Tan, Omur Taskin, Sukainah Alfaraj, Faten F AbdelHafez, Ahmed H Abdellah, Mohamed A Bedaiwy
Recurrent pregnancy loss (RPL) is a common, yet elusive, complication of pregnancy. Among couples at high risk of RPL, such as those carrying a structural chromosomal rearrangement, preimplantation genetic diagnosis (PGD) has been proposed as a tool to improve live birth rates and reduce the incidence of miscarriage; however, no clear consensus has been reached on its benefits in this population. This systematic review summarizes existing published research on the effect of PGD on pregnancy outcomes among carriers of chromosomal abnormalities with RPL...
March 15, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29602731/artificial-blastocoel-collapse-of-human-blastocysts-before-vitrification-and-its-effect-on-re-expansion-after-warming
#12
LETTER
Thomas Ebner, Omar Shebl
No abstract text is available yet for this article.
March 15, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29602727/the-applicable-scope-of-dual-trigger-which-protocol-shall-we-compare-with
#13
LETTER
Yu Xiao
No abstract text is available yet for this article.
March 15, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29622403/cryostorage-duration-does-not-affect-pregnancy-and-neonatal-outcomes-a-retrospective-single-centre-cohort-study-of-vitrified-warmed-blastocysts
#14
Satoshi Ueno, Kazuo Uchiyama, Tomoko Kuroda, Akiko Yabuuchi, Kenji Ezoe, Tadashi Okimura, Takashi Okuno, Tamotsu Kobayashi, Keiichi Kato
A retrospective cohort study of 8736 autologous single vitrified-warmed blastocyst transfer cycles was conducted in a single centre to investigate the effect of cryostorage on clinical and neonatal outcomes. Cryostorage duration was classified into two groups: (A) 0-2 months (n = 4702); (B) 2-13 months (n = 2853) and (C) 13-97 months (n = 1181). Blastocysts were vitrified using the Cryotop method. No significant differences were observed in live birth rates: (A) 37.3%; (B) 34.9%; (C) (35.2%). Gestational period was significantly shorter in group C: (A) 38...
March 14, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29598847/impact-of-androgen-supplementation-on-the-follicular-endocrine-milieu-in-women-with-hypoandrogenism
#15
LETTER
Norbert Gleicher, Vitaly A Kushnir, David H Barad
No abstract text is available yet for this article.
March 14, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29580715/response-artificial-blastocoel-collapse-of-human-blastocysts-before-vitrification-and-its-effect-on-re-expansion-after-warming
#16
LETTER
Borut Kovačič, Marjan Taborin, Veljko Vlaisavljević
No abstract text is available yet for this article.
March 14, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29598846/the-role-of-mitochondrial-activity-in-female-fertility-and-assisted-reproductive-technologies-overview-and-current-insights
#17
REVIEW
Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, Juan Antonio García-Velasco
Mitochondria have been implicated as key factors regulating female reproductive processes. Notable progress has been made in determining the role of mitochondria with respect to oocyte maturation, fertilization and early embryo development. In addition, mitochondrial function and dysfunction has been the subject of various studies in ovarian ageing and metabolic stress models. However, the overall mitochondrial impact on female fertility is yet to be uncovered. The mitochondrial DNA content of granulosa, cumulus and trophectoderm cells is being explored as a biomarker of oocyte quality and embryo viability...
March 8, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29602728/imaging-the-ovary
#18
REVIEW
Yi Feng, Amin Tamadon, Aaron J W Hsueh
During each reproductive cycle, the ovary exhibits tissue remodelling and cyclic vasculature changes associated with hormonally regulated folliculogenesis, follicle rupture, luteal formation and regression. However, the relationships among different types of follicles and corpora lutea are unclear, and the role of ovarian vasculature in folliculogenesis and luteal dynamics has not been extensively investigated. Understanding of ovarian physiology and pathophysiology relies upon elucidation of ovarian morphology and architecture...
March 6, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29656830/cairo-consensus-on-the-ivf-laboratory-environment-and-air-quality-report-of-an-expert-meeting
#19
D Mortimer, J Cohen, S T Mortimer, M Fawzy, D H McCulloh, D E Morbeck, X Pollet-Villard, R T Mansour, D R Brison, A Doshi, J C Harper, J E Swain, A V Gilligan
This proceedings report presents the outcomes from an international Expert Meeting to establish a consensus on the recommended technical and operational requirements for air quality within modern assisted reproduction technology (ART) laboratories. Topics considered included design and construction of the facility, as well as its heating, ventilation and air conditioning system; control of particulates, micro-organisms (bacteria, fungi and viruses) and volatile organic compounds (VOCs) within critical areas; safe cleaning practices; operational practices to optimize air quality while minimizing physicochemical risks to gametes and embryos (temperature control versus air flow); and appropriate infection-control practices that minimize exposure to VOC...
March 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29523398/different-patterns-of-ovarian-recovery-after-cancer-treatment-suggest-various-individual-ovarian-susceptibilities-to-chemotherapy
#20
Christine Decanter, Marc Cloquet, Audrey Dassonneville, Emmanuelle D'Orazio, Audrey Mailliez, Pascal Pigny
The relationship between early recovery of menstrual activity and blood anti-Müllerian hormone (AMH) concentrations were investigated within the first year post-chemotherapy in 32 young patients with breast cancer. All were treated by surgery and the same chemotherapy protocol (three cycles of FEC100 plus three cycles of taxanes). Menstrual activity, blood AMH (using picoAMH ELISA) and FSH concentrations were measured longitudinally before, during and up to 12 months after the end of chemotherapy (six samples per patient)...
March 2, 2018: Reproductive Biomedicine Online
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