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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/27908453/volumetric-modulated-arc-therapy-with-dynamic-collimator-rotation-for-improved-multileaf-collimator-tracking-of-the-prostate
#1
Ghulam Murtaza, Jakob Toftegaard, Ehsan Ullah Khan, Per Rugaard Poulsen
PURPOSE: To improve MLC tracking of prostate VMAT plans by dynamic rotation of the collimator to align the MLC leaves with the dominant prostate motion direction. METHODS: For 22 prostate cancer patients, two dual arc VMAT plans were made with (1) fixed collimators (45° and 315°) and (2) a rotating collimator that aligned the MLC leaves with the dominant prostate motion direction (population-based first principal component). The fixed and rotating collimator plan quality was compared using selected dose-volume indices...
November 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27894600/reply-letter-to-texture-analysis-of-parotid-gland-as-a-predictive-factor-of-radiation-induced-xerostomia-a-subset-analysis
#2
Lisanne V van Dijk, Johannes A Langendijk, Nanna M Sijtsema, Roel J H M Steenbakkers
No abstract text is available yet for this article.
November 25, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27890427/internal-and-external-generalizability-of-temporal-dose-response-relationships-for-xerostomia-following-imrt-for-head-and-neck-cancer
#3
Maria Thor, Adepitan A Owosho, Haley D Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D Thomas, Sae Hee K Yom, Jonn S Wu, Joseph M Huryn, Vitali Moiseenko, Nancy Y Lee, Cherry L Estilo, Joseph O Deasy
BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, p-values, and Hosmer-Lemeshow p-values (pHL))...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27890426/patient-reported-quality-of-life-after-stereotactic-body-radiation-therapy-versus-moderate-hypofractionation-for-clinically-localized-prostate-cancer
#4
Skyler Bryce Johnson, Pamela R Soulos, Timothy D Shafman, Constantine A Mantz, Arie P Dosoretz, Rudi Ross, Steven E Finkelstein, Sean P Collins, Simeng Suy, Jeffrey V Brower, Mark A Ritter, Christopher R King, Patrick A Kupelian, Eric M Horwitz, Alan Pollack, Matthew C Abramowitz, Mark A Hallman, Sergio Faria, Cary P Gross, James B Yu
BACKGROUND AND PURPOSE: Evaluate changes in bowel, urinary and sexual patient-reported quality of life following treatment with moderately hypofractionated radiotherapy (<5Gray/fraction) or stereotactic body radiation therapy (SBRT;5-10Gray/fraction) for prostate cancer. MATERIALS AND METHODS: In a pooled multi-institutional analysis of men treated with moderate hypofractionation or SBRT, we compared minimally detectable difference in bowel, urinary and sexual quality of life at 1 and 2years using chi-squared analysis and logistic regression...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27890425/the-changing-landscape-in-radiotherapy-for-breast-cancer-lessons-from-long-term-follow-up-in-some-european-breast-cancer-trials
#5
REVIEW
Harry Bartelink
This review describes the developments in the radiation treatment of breast cancer based on some randomized European trials during the past decades. It will focus on the relevance of long term follow-up in breast cancer patients, starting with the surprising and important change in treatment results during follow-up shown in a locally advanced breast cancer trial. Breast conserving therapy (BCT) in stage I and II breast cancer was explored and tested in a randomized trial to prove equivalence between BCT and mastectomy...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27889184/gec-estro-acrop-recommendations-for-head-neck-brachytherapy-in-squamous-cell-carcinomas-1st-update-improvement-by-cross-sectional-imaging-based-treatment-planning-and-stepping-source-technology
#6
György Kovács, Rafael Martinez-Monge, Ashwini Budrukkar, Jose Luis Guinot, Bengt Johansson, Vratislav Strnad, Janusz Skowronek, Angeles Rovirosa, Frank-André Siebert
The Head and Neck Working Group of the GEC-ESTRO (Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology) published in 2009 the consensus recommendations for low-dose rate, pulsed-dose rate and high-dose rate brachytherapy in head & neck cancers. The use of brachytherapy in combination with external beam radiotherapy and/or surgery was also covered as well as the use of brachytherapy in previously irradiated patients. Given the developments in the field, these recommendations needed to be updated to reflect up-to-date knowledge...
November 23, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27887734/two-countries-two-treatment-strategies-for-rectal-cancer
#7
Bengt Glimelius, Tor Åge Myklebust, Kristina Lundqvist, Arne Wibe, Marianne G Guren
BACKGROUND AND PURPOSE: Trials in rectal cancer have shown that radiotherapy (RT) decreases local recurrence rates, whereas the effects on survival are uncertain. Swedish and Norwegian oncologists have had different treatment recommendations. The aim was to evaluate local recurrence rates and survival in the two countries. PATIENTS AND METHODS: Between 1995 and 2012 rectal cancer patients registered in Sweden and Norway were analyzed, presenting population-based "real world" data...
November 22, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27884510/is-selective-nodal-irradiation-in-non-small-cell-lung-cancer-still-safe-when-using-imrt-results-of-a-prospective-cohort-study
#8
Hanneke M A Martinussen, Bart Reymen, Rinus Wanders, Esther G C Troost, Anne-Marie C Dingemans, Michel Öllers, Ruud Houben, Dirk De Ruysscher, Philippe Lambin, Angela van Baardwijk
BACKGROUND AND PURPOSE: Isolated nodal failures (INF) are rare after 3D-conformal radiotherapy (3D-CRT) for stage III non-small cell lung cancer (NSCLC). Since incidental nodal irradiation doses are lower with Intensity Modulated Radiation Therapy (IMRT) than with 3D-CRT, INF may be higher after IMRT. We therefore investigated the incidence of INF after IMRT in stage III NSCLC patients. MATERIALS AND METHODS: Stage III NSCLC patients undergoing radical radiotherapy using IMRT in the period January 2010 till March 2012 were included...
November 21, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27871671/tumor-control-probability-modeling-for-stereotactic-body-radiation-therapy-of-early-stage-lung-cancer-using-multiple-bio-physical-models
#9
REVIEW
Feng Liu, An Tai, Percy Lee, Tithi Biswas, George X Ding, Isaam El Naqa, Jimm Grimm, Andrew Jackson, Feng-Ming Spring Kong, Tamara LaCouture, Billy Loo, Moyed Miften, Timothy Solberg, X Allen Li
This work is to analyze pooled clinical data using different radiobiological models and to understand the relationship between biologically effective dose (BED) and tumor control probability (TCP) for stereotactic body radiotherapy (SBRT) of early-stage non-small cell lung cancer (NSCLC). The clinical data of 1-, 2-, 3-, and 5-year actuarial or Kaplan-Meier TCP from 46 selected studies were collected for SBRT of NSCLC in the literature. The TCP data were separated for Stage T1 and T2 tumors if possible, otherwise collected for combined stages...
November 18, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27866848/analysis-of-gtv-reduction-during-radiotherapy-for-oropharyngeal-cancer-implications-for-adaptive-radiotherapy
#10
Olga Hamming-Vrieze, Simon R van Kranen, Wilma D Heemsbergen, Charlotte A H Lange, Michiel W M van den Brekel, Marcel Verheij, Coen R N Rasch, Jan Jakob Sonke
BACKGROUND AND PURPOSE: Adaptive field size reduction based on gross tumor volume (GTV) shrinkage imposes risk on coverage. Fiducial markers were used as surrogate for behavior of tissue surrounding the GTV edge to assess this risk by evaluating if GTVs during treatment are dissolving or actually shrinking. MATERIALS AND METHODS: Eight patients with oropharyngeal tumors treated with chemo-radiation were included. Before treatment, fiducial markers (0.035×0.2cm(2), n=40) were implanted at the edge of the primary tumor...
November 18, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27866849/inter-observer-variation-in-delineating-the-coronary-arteries-as-organs-at-risk
#11
Anna-Karin Wennstig, Hans Garmo, Per Hållström, Petra Witt Nyström, Per Edlund, Carl Blomqvist, Malin Sund, Greger Nilsson
PURPOSE: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose. METHOD: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC...
November 17, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27865544/central-liver-toxicity-after-sbrt-an-expanded-analysis-and-predictive-nomogram
#12
Diego A S Toesca, Evan C Osmundson, Rie von Eyben, Jenny L Shaffer, Albert C Koong, Daniel T Chang
PURPOSE: To further explore the correlation of central biliary tract (cHBT) radiation doses with hepatobiliary toxicity (HBT) after stereotactic body radiation therapy (SBRT) in a larger patient dataset. METHODS: We reviewed the treatment and outcomes of all patients who received SBRT for primary liver cancer (PLC) and metastatic liver tumors between July 2004 and November 2015 at our institution. The cHBT was defined as isotropic expansions (5, 10, 15, 20 and 25mm) from the portal vein (PV)...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27865543/patterns-of-care-and-survival-outcomes-in-patients-with-pineal-parenchymal-tumor-of-intermediate-differentiation-an-individual-patient-data-analysis
#13
Supriya Mallick, Rony Benson, G K Rath
BACKGROUND/PURPOSE: Pineal parenchymal tumor constitutes less than 1% of all CNS tumors. Pineal parenchymal tumor of intermediate differentiation is a rare tumor arising from the pineal parenchyma lying between the spectrum of Pineocytoma and Pineoblastoma. METHODS AND MATERIALS: We performed PubMed search with the following MesH terms: "pineal parenchymal tumor, pineal parenchymal tumor of intermediate differentiation, pineal parenchymal tumor of intermediate differentiation AND treatment, and pineal parenchymal tumor of intermediate differentiation AND survival" to find all possible publications pertaining to PPTID...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27863964/clinical-evidence-of-variable-proton-biological-effectiveness-in-pediatric-patients-treated-for-ependymoma
#14
Christopher R Peeler, Dragan Mirkovic, Uwe Titt, Pierre Blanchard, Jillian R Gunther, Anita Mahajan, Radhe Mohan, David R Grosshans
BACKGROUND AND PURPOSE: A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness. MATERIAL AND METHODS: Fourteen of 34 children showed T2-FLAIR hyperintensity on post-treatment magnetic resonance (MR) images...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27863962/understanding-the-impact-of-pelvic-organ-motion-on-dose-delivered-to-target-volumes-during-imrt-for-cervical-cancer
#15
Gemma Eminowicz, Vasilis Rompokos, Christopher Stacey, Lisa Hall, Mary McCormack
BACKGROUND: Advanced radiotherapy techniques reduce normal tissue dose by conforming closely to target volumes. In cervical cancer radiotherapy, organ filling affects clinical target volume (CTV; cervix, uterus) position. This study estimates the dosimetric effect of this primary CTV position variation during chemoradiation. METHODS/MATERIALS: Twice weekly cone-beam computed tomography (CBCT) images of ten patients undergoing cervical chemoradiation were retrospectively analysed...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27863963/the-dose-response-of-salvage-radiotherapy-following-radical-prostatectomy-a-systematic-review-and-meta-analysis
#16
Christopher R King
PURPOSE/OBJECTIVES: To date neither the optimal radiotherapy dose nor the existence of a dose-response has been established for salvage RT (SRT). MATERIALS/METHODS: A systematic review from 1996 to 2015 and meta-analysis was performed to identify the pathologic, clinical and treatment factors associated with relapse-free survival (RFS) after SRT (uniformly defined as a PSA>0.2ng/mL or rising above post-SRT nadir). A sigmoidal dose-response curve was objectively fitted and a non-parametric statistical test used to determine significance...
November 15, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27839769/preclinical-testing-of-an-atr-inhibitor-demonstrates-improved-response-to-standard-therapies-for-esophageal-cancer
#17
Katarzyna B Leszczynska, Greg Dobrynin, Rhea E Leslie, Jonathan Ient, Adam J Boumelha, Joana M Senra, Maria A Hawkins, Tim Maughan, Somnath Mukherjee, Ester M Hammond
BACKGROUND AND PURPOSE: Esophageal cancer has a persistently low 5-year survival rate and has recently been classified as a cancer of unmet need by Cancer Research UK. Consequently, new approaches to therapy are urgently required. Here, we tested the hypothesis that an ATR inhibitor, VX-970, used in combination with standard therapies for esophageal cancer could improve treatment outcome. MATERIAL AND METHODS: Using esophageal cancer cell lines we evaluated the efficacy of combining VX-970 with cisplatin and carboplatin in vitro and with radiation in vitro and in vivo...
November 10, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27838150/three-dimensional-analysis-of-patterns-of-locoregional-recurrence-after-treatment-in-breast-cancer-patients-validation-of-the-estro-consensus-guideline-on-target-volume
#18
Jee Suk Chang, Hwa Kyung Byun, Jun Won Kim, Kyung Hwan Kim, Jeongshim Lee, Yeona Cho, Ik Jae Lee, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
BACKGROUND AND PURPOSE: To explore the validity of the ESTRO-clinical target volume (CTV), we conducted three-dimensional analyses of locoregional recurrence (LRR) patterns according to the ESTRO- and RTOG-CTVs. Moreover, we explored which factors contribute to metastasis development outside the recommended CTV. MATERIALS AND METHODS: We identified patients with post-treatment LRR explicitly exhibited on computed tomography (CT) images. All recurrences on CT were overlaid on representative CT images at the equivalent location, based on reference anatomic structures...
November 9, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27838149/radiosensitization-of-non-small-cell-lung-cancer-cells-and-xenografts-by-the-interactive-effects-of-pemetrexed-and-methoxyamine
#19
Nancy L Oleinick, Tithi Biswas, Rutulkumar Patel, Mingfang Tao, Ravi Patel, Lachelle Weeks, Neelesh Sharma, Afshin Dowlati, Stanton L Gerson, Pingfu Fu, Junran Zhang, Mitchell Machtay
BACKGROUND AND PURPOSE: The anti-folate pemetrexed is a radiosensitizer. In pre-clinical models, pemetrexed is more effective along with the base-excision-repair inhibitor methoxyamine. We tested whether methoxyamine enhances pemetrexed-mediated radiosensitization of lung adenocarcinoma cells and xenografts. MATERIALS AND METHODS: A549 and H1299 cells were evaluated for cell cycle distribution by flow cytometry, radiosensitization by clonogenic assay, and DNA repair by neutral comet assay and repair protein activation...
November 9, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27838148/the-diffusion-weighted-magnetic-resonance-imaging-dwi-predicts-the-early-response-of-esophageal-squamous-cell-carcinoma-to-concurrent-chemoradiotherapy
#20
Lan Wang, Lihong Liu, Chun Han, Shutang Liu, Hua Tian, Zhensheng Li, Xuejiao Ren, Gaofeng Shi, Qi Wang, Guangda Wang
PURPOSE: To investigate the predictive value of serial diffusion-weighted MRI (DWI) on tumor response of the concurrent chemoradiotherapy (CCRT) for esophageal squamous cell carcinoma (ESCC) and to determine the optimal time point of DWI measurements. METHODS AND MATERIALS: From June 2010 to October 2011, 38 ESCC patients were consecutively enrolled into this prospective cohort study. During their treatment, the longitudinal DWIs were acquired at beginning and every week during the course of CCRT...
November 9, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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