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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/30642685/a-global-call-for-increased-interdisciplinary-oncologic-education
#1
LETTER
Adil S Akthar, Daniel W Golden
No abstract text is available yet for this article.
January 11, 2019: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30642684/response-to-golden-dw-et-al-a-global-call-for-increased-interdisciplinary-oncologic-education
#2
LETTER
Niall O'Higgins, Jesper Grau-Eriksen, Lynda Wyld, Kim Benstead
No abstract text is available yet for this article.
January 11, 2019: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30563693/corrigendum-to-dose-painting-by-numbers-based-on-retrospectively-determined-recurrence-probabilities-radiother-oncol-122-2017-236-241
#3
Eric Grönlund, Silvia Johansson, Anders Montelius, Anders Ahnesjö
No abstract text is available yet for this article.
December 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30551889/functional-swallowing-units-fsus-as-organs-at-risk-for-radiotherapy-part-2-advanced-delineation-guidelines-for-fsus
#4
Agata Gawryszuk, Hendrik P Bijl, Monique Holwerda, Gyorgy B Halmos, Jan Wedman, Max J H Witjes, Anton M van der Vliet, Bart Dorgelo, Johannes A Langendijk
BACKGROUND AND PURPOSE: In a separate article (PART 1), a rationale and explanation of the physiology-and-anatomy-based concept of Functional Swallowing Units (FSUs) was presented. FSUs are swallowing muscles not included in the set of commonly defined swallowing organs at risk (SWOARs). They are involved in three crucial swallowing components: hyolaryngeal elevation (HLE), tongue base retraction (TBR) and tongue motion. This paper is a continuation of PART 1 and it provides detailed computed tomography (CT)-based delineation guidelines for FSUs, which presumably are also at risk of radiation-induced dysphagia...
December 11, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30448003/4d-liver-tumor-localization-using-cone-beam-projections-and-a-biomechanical-model
#5
You Zhang, Michael R Folkert, Bin Li, Xiaokun Huang, Jeffrey J Meyer, Tsuicheng Chiu, Pam Lee, Joubin Nasehi Tehrani, Jing Cai, David Parsons, Xun Jia, Jing Wang
PURPOSE: To improve the accuracy of liver tumor localization, this study tests a biomechanical modeling-guided liver cone-beam CT (CBCT) estimation (Bio-CBCT-est) technique, which generates new CBCTs by deforming a prior high-quality CT or CBCT image using deformation vector fields (DVFs). The DVFs can be used to propagate tumor contours from the prior image to new CBCTs for automatic 4D tumor localization. METHODS/MATERIALS: To solve the DVFs, the Bio-CBCT-est technique employs an iterative scheme that alternates between intensity-driven 2D-3D deformation and biomechanical modeling-guided DVF regularization and optimization...
November 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30448002/survival-impact-of-radiotherapy-interruption-in-nasopharyngeal-carcinoma-in-the-intensity-modulated-radiotherapy-era-a-big-data-intelligence-platform-based-analysis
#6
Ji-Jin Yao, Fan Zhang, Tian-Sheng Gao, Wang-Jian Zhang, Wayne R Lawrence, Bao-Ting Zhu, Guan-Qun Zhou, Jun Ma, Si-Yang Wang, Ying Sun
PURPOSE: To evaluate the effect of radiotherapy interruption (RTI) in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). PATIENTS AND METHODS: A total of 7826 patients using the well-established big-data intelligence platform were identified. Computer-generated random numbers were used to assign these patients into a training cohort (n = 3913 patients) and an internal validation cohort (n = 3913 patients). RTI was defined as the difference between radiation treatment time and planned radiation time (assuming a Monday start)...
November 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30448001/independent-knowledge-based-treatment-planning-qa-to-audit-pinnacle-autoplanning
#7
Tomas M Janssen, Martijn Kusters, Yibing Wang, Geert Wortel, Rene Monshouwer, Eugène Damen, Steven F Petit
BACKGROUND AND PURPOSE: With the advent of automatic treatment planning options like Pinnacle's Autoplanning (PAP), the challenge arises how to assess the quality of a plan that no dosimetrist did work on. The aim of this study was to assess plan quality consistency of PAP prostate cancer patients in clinical practice. MATERIALS AND METHODS: 100 prostate cancer patients were included from NKI and 129 from RadboudUMC (RUMC). Per institute a previously developed [1] treatment planning QA model, based on overlap volume histograms, was trained on PAP plans to predict achievable dose metrics which were then compared to the clinical PAP plans...
November 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446320/location-of-arm-draining-lymph-node-in-relation-to-breast-cancer-radiotherapy-field-and-target-volume
#8
Wei Wang, Rachel Ward, Dan Jia, Simon Ashworth, Edgar Estoesta, Trevor Moodie, Verity Ahern, Kirsty Stuart, Nicholas Ngui, James French, Elisabeth Elder, David Farlow
BACKGROUND: Lymphoedema of the arm following axillary surgery or radiotherapy remains a significant side effect affecting some women after breast cancer treatment. Axillary reverse mapping (ARM) is a technique used to identify the lymph node draining the arm (ARM node). Our study aim was to examine the location of the ARM nodes in relation to target volumes and treatment fields for breast cancer radiotherapy. MATERIALS AND METHODS: Eighteen breast cancer patients underwent lymphoscintigraphy of contralateral arm (left 10, right 8) and SPECT CT scan on a research study...
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446319/reply-to-laprie-a-et-al
#9
Johannes A Langendijk, Esther G C Troost, Karin Haustermans, Cai Grau, Damien Charles Weber
No abstract text is available yet for this article.
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446318/quantification-of-cardiac-subvolume-dosimetry-using-a-17-segment-model-of-the-left-ventricle-in-breast-cancer-patients-receiving-tangential-beam-radiotherapy
#10
Simon Tang, James Otton, Lois Holloway, Geoffrey P Delaney, Gary Liney, Armia George, Michael Jameson, David Tran, Vikneswary Batumalai, Liza Thomas, Eng-Siew Koh
PURPOSE: Subacute changes following breast radiotherapy have been demonstrated in discrete areas of the left ventricle (LV), with recent guidelines being developed to help determine dose to subvolumes of the LV. This study aims to determine doses to the 17 segments of the LV as per the American Heart Association (AHA) and other cardiac subvolumes, and to correlate mean heart (MHD) dose with various subvolume dosimetric indices. These results may direct focus to specific left ventricular segments in studies of radiation-related heart disease incorporating surveillance imaging, help to determine more precise dose response relationships, and potentially aid prediction of late radiation effects...
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446317/comment-on-long-term-risks-of-secondary-cancer-for-various-whole-and-partial-breast-irradiation-techniques
#11
Hamid Ghaznavi
No abstract text is available yet for this article.
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446316/influence-of-volumetric-modulated-arc-therapy-and-fet-pet-scanning-on-treatment-outcomes-for-glioblastoma-patients
#12
P Munck Af Rosenschold, I Law, S Engelholm, S A Engelholm, A Muhic, M J Lundemann, H Roed, K Grunnet, H Skovgaard Poulsen
BACKGROUND: We sought to assess the influence of the clinical introduction of new radiotherapy technologies on glioblastoma patients' outcomes. METHODS: Newly diagnosed glioblastoma patients treated with 60 Gy and temozolomide (2005-2014) were analyzed. The patients' GTV and CTV were defined based on MR (n = 521) or FET-PET/MR (n = 190), and were treated using conformal radiotherapy (CRT, n = 159) or image-guided volumetric modulated arc therapy with hippocampal sparing (IG-VMAT, n = 362)...
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30446315/patterns-of-re-irradiation-for-recurrent-gliomas-and-validation-of-a-prognostic-score
#13
Cathalijne C B Post, Miranda C A Kramer, Ernst J Smid, Hiske L van der Weide, Catharina E Kleynen, Mart A A M Heesters, Joost J C Verhoeff
PURPOSE OR OBJECTIVE: Re-irradiation is a generally accepted method for salvage treatment in patients with recurrent glioma. However, no standard radiation regimen has been defined. This study aims to compare the efficacy and safety of different treatment regimens and to independently externally validate a recently published reirradiation risk score. MATERIAL AND METHODS: We retrospectively analyzed a cohort of patients with recurrent malignant glioma treated with salvage conventionally fractionated (CFRT), hypofractionated (HFRT) or stereotactic radiotherapy (SRT) between 2007 and 2017 at the University Medical Centers in Utrecht and Groningen...
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30442378/corrigendum-to-nuclear-egfr-as-a-molecular-target-in-cancer-radiother-oncol-108-2013-370-77
#14
Toni M Brand, Mari Iida, Neha Luthar, Megan M Starr, Evan J Huppert, Deric L Wheeler
No abstract text is available yet for this article.
November 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30424894/external-validation-of-a-prognostic-model-incorporating-quantitative-pet-image-features-in-oesophageal-cancer
#15
Kieran G Foley, Zhenwei Shi, Philip Whybra, Petros Kalendralis, Ruben Larue, Maaike Berbee, Meindert N Sosef, Craig Parkinson, John Staffurth, Tom D L Crosby, Stuart Ashley Roberts, Andre Dekker, Leonard Wee, Emiliano Spezi
AIM: Enhanced prognostic models are required to improve risk stratification of patients with oesophageal cancer so treatment decisions can be optimised. The primary aim was to externally validate a published prognostic model incorporating PET image features. Transferability of the model was compared using only clinical variables. METHODS: This was a Transparent Reporting of a multivariate prediction model for Individual Prognosis Or Diagnosis (TRIPOD) type 3 study...
November 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30420235/functional-swallowing-units-fsus-as-organs-at-risk-for-radiotherapy-part-1-physiology-and-anatomy
#16
Agata Gawryszuk, Hendrik P Bijl, Monique Holwerda, Gyorgy B Halmos, Jan Wedman, Max J H Witjes, Anton M van der Vliet, Bart Dorgelo, Johannes A Langendijk
BACKGROUND AND PURPOSE: When optimising radiotherapy treatments today, the pharyngeal constrictor muscles and the larynx are usually regarded as the swallowing organs at risk (SWOARs). The purpose of this study was to identify and describe additional, previously undefined groups of muscles (functional units) involved in crucial components of swallowing (hyolaryngeal elevation (HLE), tongue base retraction (TBR) and tongue motion), and to emphasise their relevance in radiation-induced dysphagia...
November 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30420234/use-of-a-novel-atlas-for-muscles-of-mastication-to-reduce-inter-observer-variability-in-head-and-neck-radiotherapy-contouring
#17
Christina Hague, William Beasley, Lynne Dixon, Simona Gaito, Kate Garcez, Andrew Green, Lip W Lee, Massimo Maranzano, Andrew McPartlin, Hitesh Mistry, Damian Mullan, Andrew J Sykes, David Thomson, Marcel Van Herk, Catharine M West, Nick Slevin
PURPOSE/OBJECTIVE(S): Trismus is caused by injury to the masticatory muscles resulting from cancer or its treatment. Contouring these muscles to reduce dose and radiation related trismus can be problematic due to interobserver variability. This study aimed to evaluate the reduction in interobserver variability achievable with a new contouring atlas. MATERIALS/METHODS: The atlas included: medial and lateral pterygoids (MP, LP), masseter (M) and temporalis (T) muscles, and the temporo-mandibular joint (TMJ)...
November 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30416046/doses-of-radiation-to-the-pericardium-instead-of-heart-are-significant-for-survival-in-patients-with-non-small-cell-lung-cancer
#18
Jianxin Xue, Chengbo Han, Andrew Jackson, Chen Hu, Huan Yao, Weili Wang, James Hayman, Weijun Chen, Jianyue Jin, Gregory P Kalemkerian, Martha Matuzsak, Struti Jolly, Feng-Ming Spring Kong
BACKGROUND AND PURPOSE: Higher cardiac dose was associated with worse overall survival in the RTOG0617 study. Pericardial effusion (PCE) is a common cardiac complication of thoracic radiation therapy (RT). We investigated whether doses of radiation to the heart and pericardium are associated with PCE and overall survival in patients treated with thoracic radiation for non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: A total of 94 patients with medically inoperable/unresectable NSCLC treated with definitive RT in prospective studies were reviewed for this secondary analysis...
November 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30416045/high-dose-rate-brachytherapy-monotherapy-versus-low-dose-rate-brachytherapy-with-or-without-external-beam-radiotherapy-for-clinically-localized-prostate-cancer
#19
Hideya Yamazaki, Koji Masui, Gen Suzuki, Satoaki Nakamura, Kei Yamada, Koji Okihara, Takumi Shiraishi, Ken Yoshida, Tadayuki Kotsuma, Eiichi Tanaka, Keisuke Otani, Yasuo Yoshioka, Kazuhiko Ogawa
BACKGROUND: To compare the outcome of high-dose-rate interstitial brachytherapy (HDR-BT) monotherapy and low-dose-rate brachytherapy (LDR-BT) with or without external beam radiotherapy (EBRT) for localized prostate cancer. METHODS AND MATERIALS: We compared 352 patients treated with HDR-BT as monotherapy (median follow-up time 84 months, NCCN risk classification; low: intermediate: high = 28:145:179) and 486 patients with LDR-BT with or without EBRT (90 months, 194:254:38)...
November 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30416044/vulnerabilities-of-radiomic-signature-development-the-need-for-safeguards
#20
Mattea L Welch, Chris McIntosh, Benjamin Haibe-Kains, Michael F Milosevic, Leonard Wee, Andre Dekker, Shao Hui Huang, Thomas G Purdie, Brian O'Sullivan, Hugo J W L Aerts, David A Jaffray
PURPOSE: Refinement of radiomic results and methodologies is required to ensure progression of the field. In this work, we establish a set of safeguards designed to improve and support current radiomic methodologies through detailed analysis of a radiomic signature. METHODS: A radiomic model (MW2018) was fitted and externally validated using features extracted from previously reported lung and head and neck (H&N) cancer datasets using gross-tumour-volume contours, as well as from images with randomly permuted voxel index values; i...
November 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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