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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/30021697/long-term-outcome-of-skull-base-chondrosarcoma-patients-treated-with-high-dose-proton-therapy-with-or-without-conventional-radiation-therapy
#1
Damien C Weber, Fritz Murray, Christophe Combescure, Valentin Calugaru, Claire Alapetite, Francesca Albertini, Stephanie Bolle, Farid Goudjil, Alessia Pica, Marc Walser, Hamid Mammar, Barbara Bachtiary, Tony Lomax, Georges Noël, Rémi Dendale, Loic Feuvret
BACKGROUND AND PURPOSE: Skull-base chondrosarcoma (ChSa) is a rare bone tumor and the outcome of patients with this malignancy has been documented only in a limited number of series with a restricted number of patients. OBJECTIVE: This study was conducted to assess the outcome and prognostic factors of a large cohort of ChSa patients treated with radiotherapy in two proton therapy centers. MATERIALS AND METHODS: From 1996 to 2015, 251 (male, 43...
July 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30021696/responding-to-veiga-et-al-long-term-radiological-features-of-radiation-induced-lung-damage
#2
LETTER
Ezgi Oymak, Berna Akkus Yildirim, Ozan Cem Guler, Cem Onal
No abstract text is available yet for this article.
July 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30017105/inhomogeneous-tumor-dose-distribution-provides-better-local-control-than-homogeneous-distribution-in-stereotactic-radiotherapy-for-brain-metastases
#3
François Lucia, Stéphane Key, Gurvan Dissaux, Gaëlle Goasduff, Anne-Sophie Lucia, Luc Ollivier, Olivier Pradier, Ulrike Schick
INTRODUCTION: The aim of this study was to analyze the impact of inhomogeneous versus homogeneous dose distribution on local control (LC) and radionecrosis (RN) in patients treated with fractionated stereotactic radiotherapy (SRT) for newly-diagnosed brain metastases (BM). PATIENTS AND METHODS: From 2014 to 2017, 134 patients (median age 61 years) underwent SRT for BM (n = 114 with ≤2, n = 20 with 3-6 BM) at our institution. Treatment was delivered using volumetric modulated arc therapy on a linear accelerator...
July 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30017104/is-there-a-role-for-salvage-re-irradiation-in-pediatric-patients-with-locoregional-recurrent-rhabdomyosarcoma-clinical-outcomes-from-a-multi-institutional-cohort
#4
Daniel V Wakefield, Bree R Eaton, Austin P H Dove, Chih-Yang Hsu, Thomas E Merchant, Alberto Pappo, Andrew M Davidoff, Natia Esiashvili, Matthew J Krasin, John T Lucas
BACKGROUND AND PURPOSE: Limited data exist detailing the role of salvage reirradiation following local-regional recurrence (LR) in previously irradiated pediatric patients with rhabdomyosarcoma (RMS). MATERIALS AND METHODS: We evaluated outcomes and prognostic factors in a multi-institutional cohort of 23 patients with LR-only (N = 19) or LR with distant failure (N = 4) RMS managed with (N = 12) or without (N = 11) re-irradiation who were treated from 1996 to 2012...
July 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30005954/tumor-to-cervical-spinal-cord-standardized-uptake-ratio-sur-improves-the-reproducibility-of-18-f-fdg-pet-based-tumor-segmentation-in-head-and-neck-squamous-cell-carcinoma-in-a-multicenter-setting
#5
Sven van den Bosch, Tim Dijkema, Marielle E P Philippens, Chris H J Terhaard, Frank J P Hoebers, Johannes H A M Kaanders, Wim J G Oyen
BACKGROUND: In quantitative FDG-PET data analysis, normalization of the standardized uptake value (SUV) with an internal image-derived standard improves its reproducibility. In this study, the cervical spinal cord is proposed as an internal standard that is within the field of view of the radiotherapy planning PET/CT-scan in head and neck cancer. The aim is to evaluate if the tumor to cervical spinal cord standardized uptake ratio (SUR) can improve the reproducibility of a model to determine the metabolic tumor volume (MTV) on FDG-PET/CT in a multicenter setting...
July 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30005953/the-impact-of-margin-reduction-on-outcome-and-toxicity-in-head-and-neck-cancer-patients-treated-with-image-guided-volumetric-modulated-arc-therapy-vmat
#6
Arash Navran, Wilma Heemsbergen, Tomas Janssen, Olga Hamming-Vrieze, Marcel Jonker, Charlotte Zuur, Marcel Verheij, Peter Remeijer, Jan-Jakob Sonke, Michiel van den Brekel, Abrahim Al-Mamgani
BACKGROUND AND PURPOSE: In recent decades, outcomes of patients with head and neck cancer (HNC) have improved as a result of implementing several strategies, such as chemoradiation. However, these improvements were achieved at the cost of increased toxicity. One way to reduce radiation-related toxicity is by reducing the margins. MATERIALS AND METHODS: Between 2013 and 2016, 206 consecutive patients were treated with CTV-PTV margin of 5 mm and subsequently 208 patients with 3 mm margin...
July 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30001934/radiotherapy-in-asia-making-progress-step-by-step
#7
EDITORIAL
Jesper Grau Eriksen
No abstract text is available yet for this article.
July 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30001933/nhl-chirex-an-interprofessional-cross-border-education-initiative-in-the-greater-region-with-a-focus-on-radiation-morbidity-and-patient-safety
#8
Guillaume Vogin, Jochen Fleckenstein, Jean-Christophe Servotte, Philippe Nickers, Anne Ebersberger, Farid Mohammad, Isabelle Bragard, Philippe Coucke, Michel Untereiner, Didier Peiffert, Marc Braun
NHL-ChirEx is an interprofessional cross-border education project that addresses the potential excess of radiation induced morbidity throughout the radiation planning and treatment process. NHL-ChirEx is supported by ESTRO and the University of the Greater Region and has been recently approved and funded under INTERREG VA Programme.
July 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30001932/union-of-light-ion-therapy-centers-in-europe-ulice-ec-fp7-objectives-and-achievements-of-joint-research-activities
#9
REVIEW
Richard Pötter, Jaques Balosso, Michael Baumann, Christoph Bert, Jim Davies, Wolfgang Enghardt, Piero Fossati, Steve Harris, Bleddyn Jones, Michael Krämer, Ramona Mayer, Ulrike Mock, Marco Pullia, Thomas Schreiner, Manjit Dosanjh, Jürgen Debus, Roberto Orecchia, Dietmar Georg
Under the umbrella of the European Network for Light Ion Therapy (ENLIGHT), the project on Union of Light Ion Centers in Europe (ULICE), which was funded by the European Commission (EC/FP7), was carried out from 2009 to 2014. Besides the two pillars on Transnational Access (TNA) and Networking Activities (NA), six work packages formed the pillar on Joint Research Activities (JRA). The current manuscript focuses on the objectives and results achieved within these research work packages: "Clinical Research Infrastructure", "Biologically Based Expert System for Individualized Patient Allocation", "Ion Therapy for Intra-Fractional Moving Targets", "Adaptive Treatment Planning for Ion Radiotherapy", "Carbon Ion Gantry", "Common Database and Grid Infrastructures for Improving Access to Research Infrastructures"...
July 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29997034/stereotactic-body-radiotherapy-for-colorectal-cancer-liver-metastases-a-systematic-review
#10
REVIEW
Fausto Petrelli, Tiziana Comito, Sandro Barni, Gianfranco Pancera, Marta Scorsetti, Antonio Ghidini
INTRODUCTION: While surgery is the preferred option for isolated, operable liver metastases from colorectal cancer (CRC), ablative techniques are endorsed for medically or technically inoperable lesions. Stereotactic body radiotherapy (SBRT) is an alternative ablative local therapy that delivers high RT doses in a few fractions to the cancer, sparing surrounding critical tissue. We have performed a systematic review of published trials to evaluate the efficacy of SBRT as a primary modality therapy for CRC liver oligometastases...
July 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29983260/comparison-of-suvmax-and-suvpeak-based-segmentation-to-determine-primary-lung-tumour-volume-on-fdg-pet-ct-correlated-with-pathology-data
#11
Susan Mercieca, José Belderbos, Judith van Loon, Kenneth Gilhuijs, Peter Julyan, Marcel van Herk
PURPOSE: The aim of the study was to compare simple SUVmax and SUVpeak based segmentation methods for calculating the lung tumour volume, compared to a pathology ground truth. METHODS: Thirty patients diagnosed with early stage Non-Small Cell lung cancer (NSCLC) underwent surgical resection in the Netherlands between 2006 and 2008. FDG PET-CT scans for these patients were acquired within a median of 20 days before surgery. The tumour volume for each percentage SUVmax and SUVpeak threshold, with and without background correction, was calculated for each patient...
July 5, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29983259/impact-of-radiotherapy-underutilisation-measured-by-survival-shortfall-years-of-potential-life-lost-and-disability-adjusted-life-years-lost-in-new-south-wales-australia
#12
Vikneswary Batumalai, Jesmin Shafiq, Gabriel Gabriel, Timothy P Hanna, Geoff P Delaney, Michael Barton
BACKGROUND AND PURPOSE: Despite evidence of the benefits of radiotherapy (RT) in the treatment of cancer patients, its underutilisation has been reported for various tumour sites. The aim of this study was to estimate survival shortfall, 'years of potential life lost' (YPLL) and 'disability-adjusted life years lost' (DALY) to demonstrate the impact of radiotherapy underutilisation in Australia. MATERIALS AND METHODS: Optimal and actual RT utilisation (RTU) was compared to assess RT underutilisation to estimate 5-year overall survival shortfall using 2006 data from New South Wales (NSW) for 26 common tumour sites...
July 5, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29980320/predictors-for-poor-cosmetic-outcome-in-patients-with-early-stage-breast-cancer-treated-with-breast-conserving-therapy-results-of-the-young-boost-trial
#13
Patricia J A M Brouwers, Erik van Werkhoven, Harry Bartelink, Alain Fourquet, Claire Lemanski, Judith van Loon, John H Maduro, Nicola S Russell, Luc J E E Scheijmans, Dominic A X Schinagl, Antonia H Westenberg, Philip Poortmans, Liesbeth J Boersma
PURPOSE: In the Young Boost trial (YBT), breast cancer patients ≤50 years of age, treated with breast conserving therapy (BCT) were randomized between a 26 Gy boost dose and a 16 Gy boost dose, with local recurrence as primary and cosmetic outcome (CO) as secondary endpoint. Data of the YBT was used to investigate which factors are related with worse cosmetic outcome after BCT. METHODS: From 2004 to 2011, 2421 cT1-2N0-2a breast cancer patients were randomized...
July 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29970259/fully-automated-multi-criterial-planning-for-volumetric-modulated-arc-therapy-an-international-multi-center-validation-for-prostate-cancer
#14
Ben Heijmen, Peter Voet, Dennie Fransen, Joan Penninkhof, Maaike Milder, Hafid Akhiat, Pierluigi Bonomo, Marta Casati, Dietmar Georg, Gregor Goldner, Ann Henry, John Lilley, Frank Lohr, Livia Marrazzo, Stefania Pallotta, Roberto Pellegrini, Yvette Seppenwoolde, Gabriele Simontacchi, Volker Steil, Florian Stieler, Stuart Wilson, Sebastiaan Breedveld
BACKGROUND AND PURPOSE: Reported plan quality improvements with autoplanning of radiotherapy of the prostate and seminal vesicles are poor. A system for automated multi-criterial planning has been validated for this treatment in a large international multi-center study. The system is configured with training plans using a mechanism that strives for quality improvements relative to those plans. MATERIAL AND METHODS: Each of the four participating centers included thirty manually generated clinical Volumetric Modulated Arc Therapy prostate plans (manVMAT)...
June 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29961582/response-to-spartalis-et-al
#15
LETTER
Raphaël Jumeau, Mahmut Ozsahin, Raphaël Moeckli, Etienne Pruvot, Jean Bourhis
No abstract text is available yet for this article.
June 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29961581/radiotherapy-dose-volume-parameters-predict-videofluoroscopy-detected-dysphagia-per-digest-after-imrt-for-oropharyngeal-cancer-results-of-a-prospective-registry
#16
Mona Kamal, Abdallah S R Mohamed, Stefania Volpe, Jhankruti Zaveri, Martha Portwood Barrow, G Brandon Gunn, Stephen Y Lai, Renata Ferrarotto, Jan S Lewin, David I Rosenthal, Amit Jethanandani, Mohamed Ahmed Mohamed Meheissen, Samuel L Mulder, Carlos E Cardenas, Clifton D Fuller, Katherine A Hutcheson
PURPOSE: Our primary aim was to prospectively validate retrospective dose-response models of chronic radiation-associated dysphagia (RAD) after intensity modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC). The secondary aim was to validate a grade ≥2 cut-point of the published videofluoroscopic dysphagia severity (Dynamic Imaging Grade for Swallowing Toxicity, DIGEST) as radiation dose-dependent. MATERIAL AND METHODS: Ninety-seven patients enrolled on an IRB-approved prospective registry protocol with stage I-IV OPC underwent pre- and 3-6 month post-RT videofluoroscopy...
June 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29960685/stereotactic-radiosurgery-and-immunotherapy-in-melanoma-brain-metastases-patterns-of-care-and-treatment-outcomes
#17
Prashant Gabani, Benjamin W Fischer-Valuck, Tanner M Johanns, Leonel F Hernandez-Aya, Jesse W Keller, Keith M Rich, Albert H Kim, Gavin P Dunn, Clifford G Robinson, Michael R Chicoine, Jiayi Huang, Christopher D Abraham
PURPOSE: Preclinical studies have suggested that radiation therapy (RT) enhances antitumor immune response and can act synergistically when administered with immunotherapy. However, this effect in melanoma brain metastasis is not well studied. We aim to explore the clinical effect of combining RT and immunotherapy in patients with melanoma brain metastasis (MBM). MATERIALS AND METHODS: Patients with MBM between 2011 and 2013 were obtained from the National Cancer Database...
June 27, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29960684/adjuvant-postoperative-high-dose-radiotherapy-for-atypical-and-malignant-meningioma-a-phase-ii-parallel-non-randomized-and-observation-study-eortc-22042-26042
#18
Damien C Weber, Carmen Ares, Salvador Villa, Saskia M Peerdeman, Laurette Renard, Brigitta G Baumert, Anna Lucas, Theo Veninga, Alessia Pica, Sarah Jefferies, Umberto Ricardi, Raymond Miralbell, Jean-Jacques Stelmes, Yan Liu, Laurence Collette, Sandra Collette
PURPOSE: The therapeutic strategy for non-benign meningiomas is controversial. The objective of this study was to prospectively investigate the impact of high dose radiation therapy (RT) on the progression-free survival (PFS) rate at 3 years in WHO grade II and III meningioma patients. MATERIALS AND METHODS: In this multi-cohorts non-randomized phase II and observational study, non-benign meningioma patients were treated according to their WHO grade and Simpson's grade...
June 27, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29958772/parotid-gland-fat-related-magnetic-resonance-image-biomarkers-improve-prediction-of-late-radiation-induced-xerostomia
#19
Lisanne V van Dijk, Maria Thor, Roel J H M Steenbakkers, Aditya Apte, Tian-Tian Zhai, Ronald Borra, Walter Noordzij, Cherry Estilo, Nancy Lee, Johannes A Langendijk, Joseph O Deasy, Nanna M Sijtsema
PURPOSE: This study investigated whether Magnetic Resonance image biomarkers (MR-IBMs) were associated with xerostomia 12 months after radiotherapy (Xer12m ) and to test the hypothesis that the ratio of fat-to-functional parotid tissue is related to Xer12m . Additionally, improvement of the reference Xer12m model based on parotid gland dose and baseline xerostomia, with MR-IBMs was explored. METHODS: Parotid gland MR-IBMs of 68 head and neck cancer patients were extracted from pre-treatment T1-weighted MR images, which were normalized to fat tissue, quantifying 21 intensity and 43 texture image characteristics...
June 26, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29945720/a-global-unified-dosimetry-index-gudi-to-evaluate-simultaneous-integrated-boost-radiotherapy-plans-in-prostate-cancer
#20
Maddalena Mambretti, Chiara Romanò, Giulia Marvaso, Stefania Comi, Raffaella Cambria, Delia Ciardo, Francesca Emiro, Cristiana Fodor, Dario Zerini, Giulia Riva, Giuseppe Petralia, Ottavio De Cobelli, R Orecchia, Federica Cattani, Barbara Alicja Jereczek-Fossa
PURPOSE: Formulation of a global Unified Dosimetry Index (gUDI) for the evaluation of prostate simultaneous integrated boost Volumetric Modulated Arc Therapy (VMAT by RapidArc) radiotherapy plans. METHODS AND MATERIALS: Dose coverage, conformity, homogeneity and dose gradient index could be included in the Unified Dosimetry Index (UDI). We developed a global UDI to evaluate treatment plans containing volumes irradiated with different dose prescriptions: Intensity Modulated Radiation Therapy with simultaneous integrated boost (IMRT-SIB) with 2 dose levels (36...
June 23, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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