journal
MENU ▼
Read by QxMD icon Read
search

Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

journal
https://www.readbyqxmd.com/read/28801008/the-course-of-quality-of-life-and-neurocognition-in-newly-diagnosed-patients-with-glioblastoma
#1
B Flechl, C Sax, M Ackerl, R Crevenna, A Woehrer, J Hainfellner, M Preusser, G Widhalm, B Kiesel, C Lütgendorf-Caucig, K Dieckmann, C Steffal, C Marosi, M R Hassler
BACKGROUND: The importance of QoL and neurocognitive functions in patients with glioblastoma (GB) is above controversy by now. We followed newly diagnosed GB patients treated with radio-chemotherapy during their course of disease by continuously evaluating their quality of life (QoL) and cognitive functions. METHODS: We included consecutive patients with newly diagnosed GB from 2010 to 2013 at the Medical University of Vienna. To assess QoL the EORTC QLQ C30 and BN20 questionnaire were used...
August 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28797700/4dct-imaging-to-assess-radiomics-feature-stability-an-investigation-for-thoracic-cancers
#2
Ruben T H M Larue, Lien Van De Voorde, Janna E van Timmeren, Ralph T H Leijenaar, Maaike Berbée, Meindert N Sosef, Wendy M J Schreurs, Wouter van Elmpt, Philippe Lambin
BACKGROUND AND PURPOSE: Quantitative tissue characteristics derived from medical images, also called radiomics, contain valuable prognostic information in several tumour-sites. The large number of features available increases the risk of overfitting. Typically test-retest CT-scans are used to reduce dimensionality and select robust features. However, these scans are not always available. We propose to use different phases of respiratory-correlated 4D CT-scans (4DCT) as alternative. MATERIALS AND METHODS: In test-retest CT-scans of 26 non-small cell lung cancer (NSCLC) patients and 4DCT-scans (8 breathing phases) of 20 NSCLC and 20 oesophageal cancer patients, 1045 radiomics features of the primary tumours were calculated...
August 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28797699/the-novel-microtubule-targeting-agent-bal101553-in-combination-with-radiotherapy-in-treatment-refractory-tumor-models
#3
Ashish Sharma, Angela Broggini-Tenzer, Van Vuong, Alessandra Messikommer, Katarzyna J Nytko, Matthias Guckenberger, Felix Bachmann, Heidi A Lane, Martin Pruschy
BACKGROUND AND PURPOSE: Resistance to microtubule targeting agents (MTA) represents a major drawback in successful cancer therapy with MTAs. Here we investigated the combined treatment modality of the novel MTA BAL101553 in combination with radiotherapy in paclitaxel and epothilone-resistant tumor models. MATERIAL AND METHODS: Multiple regimens of BAL101553, or its active moiety BAL27862 for in vitro experiments, were probed in combination with radiotherapy in P-glycoprotein-overexpressing, human colon adenocarcinoma cells (SW480) and in tubulin-mutated human NSCLC cells (A549EpoB40) and tumors thereof...
August 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28789809/preclinical-validation-of-111-in-girentuximab-f-ab-2-as-a-tracer-to-image-hypoxia-related-marker-caix-expression-in-head-and-neck-cancer-xenografts
#4
Fokko J Huizing, Bianca A W Hoeben, Gerben Franssen, Jasper Lok, Sandra Heskamp, Egbert Oosterwijk, Otto C Boerman, Johan Bussink
BACKGROUND AND PURPOSE: Hypoxia is a major cause of radio- and chemoresistance. Carbonic anhydrase IX (CAIX) is an endogenous hypoxia-related marker and an important prognostic marker. Assessment of CAIX expression may allow patient selection for hypoxia or CAIX-targeted treatment. The radioactive tracer (111)In-girentuximab-F(ab')2 targets CAIX and can be used for SPECT imaging. Aim of this study was to validate and optimize (111)In-girentuximab-F(ab')2 for imaging of CAIX expression in head and neck tumor xenografts...
August 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28784439/radiosensitization-by-gold-nanoparticles-will-they-ever-make-it-to-the-clinic
#5
REVIEW
Lei Cui, Sohyoung Her, Gerben R Borst, Robert G Bristow, David A Jaffray, Christine Allen
The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in pre-clinical research. In the current review, the physical, chemical, and biological pathways via which AuNPs enhance the effects of radiation are presented and discussed. In particular, the impact of AuNPs on the 5 Rs in radiobiology, namely repair, reoxygenation, redistribution, repopulation, and intrinsic radiosensitivity, which determine the extent of radiation enhancement effects are elucidated. Key findings from previous studies are outlined...
August 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28784438/role-of-glial-cell-derived-neurotrophic-factor-in-salivary-gland-stem-cell-response-to-irradiation
#6
Xiaohong Peng, Kärt Varendi, Martti Maimets, Jaan-Olle Andressoo, Rob P Coppes
BACKGROUND AND PURPOSE: Recently, stem cell therapy has been proposed to allow regeneration of radiation damaged salivary glands. It has been suggested that glial-cell-derived neurotrophic factor (GDNF) promotes survival of mice salivary gland stem cells (mSGSCs). The purpose of this study was to investigate the role of GDNF in the modulation of mSGSC response to irradiation and subsequent salivary gland regeneration. METHODS: Salivary gland sphere derived cells of Gdnf hypermorphic (Gdnf(wt/hyper)) and wild type mice (Gdnf(wt/wt)) were irradiated (IR) with γ-rays at 0, 1, 2, 4 and 8Gy...
August 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28784437/carbon-ion-re-irradiation-for-recurrences-after-initial-treatment-of-stage-i-non-small-cell-lung-cancer-with-carbon-ion-radiotherapy
#7
Masataka Karube, Naoyoshi Yamamoto, Hiroshi Tsuji, Nobuyuki Kanematsu, Mio Nakajima, Hideomi Yamashita, Keiichi Nakagawa, Tadashi Kamada
PURPOSE: To investigate carbon-ion radiotherapy (CIRT) for in-field recurrence of stage I non-small cell lung cancer (NSCLC) initially treated with CIRT. MATERIALS AND METHODS: From January 2007 to March 2014, patients initially treated for stage I NSCLC with CIRT and relapsed in-field were candidates. Overall survival (OS) rate, local control (LC) rate, progressive free survival (PFS) rate, dose to the lungs and skin, and adverse effects were analyzed. RESULTS: Twenty-nine patients were eligible...
August 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28778348/benefit-from-the-inclusion-of-radiation-therapy-in-the-treatment-of-patients-with-stage-iii-classical-hodgkin-lymphoma-a-propensity-matched-analysis-of-the-surveillance-epidemiology-and-end-results-database
#8
James E Bates, Sughosh Dhakal, Ali Mazloom, Carla Casulo, Louis S Constine
BACKGROUND: While stage III and IV classical Hodgkin lymphoma (HL) patients are often combined and defined as "advanced stage," there are significant differences in disease distribution and burden between the two stages. This may obscure advantages of radiotherapy (RT) in a combined modality therapy strategy in stage III disease due to the relative lack of benefit in stage IV patients. METHODS: We queried the Surveillance, Epidemiology, and End Results (SEER) database, restricting our search to patients with stage III classical HL diagnosed from 2004 to 2012, to examine the difference in overall and cause-specific survival (OS and CSS) between patients who did or did not receive RT...
August 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28778347/overall-survival-advantage-of-chemotherapy-and-radiotherapy-in-the-perioperative-management-of-large-extremity-and-trunk-soft-tissue-sarcoma-a-large-database-analysis
#9
Omar Mahmoud, Ahmet Tunceroglu, Ravi Chokshi, Joseph Benevenia, Kathleen Beebe, Francis Patterson, Thomas F DeLaney
PURPOSE: Intergroup 9514 reported promising outcomes with neoadjuvant chemoradiotherapy for large extremity/trunk soft tissue sarcoma (ESTS). One decade later, optimum integration of chemotherapy and radiotherapy into the perioperative management of ESTS remains to be defined. METHODS: The National Cancer Data Base was used to identify 3422 patients who underwent resection for large (>8cm) high-grade STS between 2004 and 2013. Chi-square analysis was used to evaluate distribution of patient and tumor related factors within treatment groups while multivariate analyses were used to determine the impact of these factors on patient outcome...
August 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28778346/early-assessment-of-dosimetric-and-biological-differences-of-total-marrow-irradiation-versus-total-body-irradiation-in-rodents
#10
Susanta Hui, Yutaka Takahashi, Shernan G Holtan, Rezvan Azimi, Davis Seelig, Masashi Yagi, Jessie Ingvalson, Parham Alaei, Leslie Sharkey, Behiye Kodal, Nicholas Peterson, Carolyn Meyer, Lindsey Godin, Michael Ehrhardt, Guy Storme, Daohong Zhou, Angela Panoskaltsis-Mortari
PURPOSE: To develop a murine total marrow irradiation (TMI) model in comparison with the total body irradiation (TBI) model. MATERIALS AND METHODS: Myeloablative TMI and TBI were administered in mice using a custom jig, and the dosimetric differences between TBI and TMI were evaluated. The early effects of TBI/TMI on bone marrow (BM) and organs were evaluated using histology, FDG-PET, and cytokine production. TMI and TBI with and without cyclophosphamide (Cy) were evaluated for donor cell engraftment and tissue damage early after allogeneic hematopoietic cell transplantation (HCT)...
August 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28778345/patterns-of-failure-in-limited-stage-small-cell-lung-cancer-implications-of-tnm-stage-for-prophylactic-cranial-irradiation
#11
Abraham J Wu, Andrea Gillis, Amanda Foster, Kaitlin Woo, Zhigang Zhang, Daphna Y Gelblum, Robert J Downey, Kenneth E Rosenzweig, Leonard Ong, Carmen A Perez, M Catherine Pietanza, Lee Krug, Charles M Rudin, Andreas Rimner
BACKGROUND AND PURPOSE: The relationship between tumor-node-metastasis (TNM) stage and patterns of failure in limited-stage small cell lung cancer (LS-SCLC) remains unclear. We hypothesized that TNM stage predicts brain metastasis risk, and could inform the use of prophylactic cranial irradiation. MATERIAL AND METHODS: We reviewed 283 patients with stage I-IIIB SCLC. Competing-risks regression was used to analyze local, distant, and brain failure. Multivariate analysis was used to evaluate the effect of treatment and clinical factors on failure and OS...
August 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28774597/nintedanib-reduces-radiation-induced-microscopic-lung-fibrosis-but-this-cannot-be-monitored-by-ct-imaging-a-preclinical-study-with-a-high-precision-image-guided-irradiator
#12
Dirk De Ruysscher, Patrick Vincent Granton, Natasja Gaby Lieuwes, Stefan van Hoof, Lutz Wollin, Birgit Weynand, Anne-Marie Dingemans, Frank Verhaegen, Ludwig Dubois
BACKGROUND: Nintedanib has anti-fibrotic and anti-inflammatory activity and is approved for the treatment of idiopathic pulmonary fibrosis. The aim of this study was to noninvasively assess the efficacy of nintedanib in a mouse model of partial lung irradiation to prevent radiation-induced lung damage (RILD). METHODS: 266 C57BL/6 adult male mice were irradiated with a single radiation dose (0, 4, 8, 12, 16 or 20Gy) using parallel-opposed fields targeting the upper right lung using a precision image-guided small animal irradiator sparing heart and spine based on micro-CT images...
July 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28774596/patterns-of-failure-guided-biological-target-volume-definition-for-head-and-neck-cancer-patients-fdg-pet-and-dosimetric-analysis-of-dose-escalation-candidate-subregions
#13
Abdallah S R Mohamed, Carlos E Cardenas, Adam S Garden, Musaddiq J Awan, Crosby D Rock, Sarah A Westergaard, G Brandon Gunn, Abdelaziz M Belal, Ahmed G El-Gowily, Stephen Y Lai, David I Rosenthal, Clifton D Fuller, Michalis Aristophanous
BACKGROUND: To identify the radio-resistant subvolumes in pretreatment FDG-PET by mapping the spatial location of the origin of tumor recurrence after IMRT for head-and-neck squamous cell cancer to the pretreatment FDG-PET/CT. METHODS: Patients with local/regional recurrence after IMRT with available FDG-PET/CT and post-failure CT were included. For each patient, both pre-therapy PET/CT and recurrence CT were co-registered with the planning CT (pCT). A 4-mm radius was added to the centroid of mapped recurrence growth target volumes (rGTV's) to create recurrence nidus-volumes (NVs)...
July 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28764926/improving-the-prediction-of-overall-survival-for-head-and-neck-cancer-patients-using-image-biomarkers-in-combination-with-clinical-parameters
#14
Tian-Tian Zhai, Lisanne V van Dijk, Bao-Tian Huang, Zhi-Xiong Lin, Cássia O Ribeiro, Charlotte L Brouwer, Sjoukje F Oosting, Gyorgy B Halmos, Max J H Witjes, Johannes A Langendijk, Roel J H M Steenbakkers, Nanna M Sijtsema
PURPOSE: To develop and validate prediction models of overall survival (OS) for head and neck cancer (HNC) patients based on image biomarkers (IBMs) of the primary tumor and positive lymph nodes (Ln) in combination with clinical parameters. MATERIAL AND METHODS: The study cohort was composed of 289 nasopharyngeal cancer (NPC) patients from China and 298 HNC patients from the Netherlands. Multivariable Cox-regression analysis was performed to select clinical parameters from the NPC and HNC datasets, and IBMs from the NPC dataset...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28764925/profile-of-european-proton-and-carbon-ion-therapy-centers-assessed-by-the-eortc-facility-questionnaire
#15
Damien C Weber, André Abrunhosa-Branquinho, Alessandra Bolsi, Andrzej Kacperek, Rémi Dendale, Dirk Geismar, Barbara Bachtiary, Annika Hall, Jens Heufelder, Klaus Herfarth, Jürgen Debus, Maurizio Amichetti, Mechthild Krause, Roberto Orecchia, Vladimir Vondracek, Juliette Thariat, Tomasz Kajdrowicz, Kristina Nilsson, Cai Grau
BACKGROUND: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. MATERIAL AND METHODS: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. RESULTS: The average number of patients treated per year and per particle center was 221 (range, 40-557)...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28764924/partial-breast-irradiation-with-interstitial-multi-catheter-high-dose-rate-brachytherapy-long-term-results-of-a-phase-ii-prospective-study
#16
Cynthia Aristei, Ernesto Maranzano, Valentina Lancellotta, Luigia Chirico, Claudio Zucchetti, Marco Italiani, Paola Anselmo, Cristina Mariucci, Elisabetta Perrucci, Fabio Arcidiacono, Fabio Trippa, György Kovacs, Vittorio Bini, Isabella Palumbo
PURPOSE: We report the long-term results of phase II prospective study with accelerated partial breast irradiation (APBI) using interstitial multi-catheter high-dose-rate brachytherapy. METHODS: 240 patients received APBI (4Gy, twice daily; total dose 32Gy). RESULTS: Median follow-up was 96months. Recurrences in the treated breast developed in 8 patients (3.3%) at a median of 73months after APBI. The 5- and 10-year cumulative incidences were respectively, 1...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28760484/pulsed-dose-rate-brachytherapy-for-pediatric-bladder-prostate-rhabdomyosarcoma-compliance-and-early-clinical-results
#17
Cyrus Chargari, Hélène Martelli, Florent Guérin, Warren Bacorro, Guénolée de Lambert, Alexandre Escande, Véronique Minard-Colin, Isabelle Dumas, Eric Deutsch, Christine Haie-Meder
OBJECTIVE: No data are available on the feasibility of pulsed dose rate (PDR) brachytherapy in very young children. Our experience of PDR brachytherapy for bladder prostate (BP) rhabdomyosarcoma (RMS) is reported, with focus on compliance and dosimetric parameters. MATERIALS AND METHODS: Treatment parameters and outcome of consecutive BP RMS patients treated in our center were examined. Treatment was carried out as part of a multimodal conservative radio-surgical treatment...
July 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28756006/upfront-vs-no-upfront-neck-dissection-in-primary-head-and-neck-cancer-radio-chemo-therapy-tumor-control-and-late-toxicity
#18
Daan Nevens, Fréderic Duprez, Katrien Bonte, Philippe Deron, Wouter Huvenne, Annouschka Laenen, Wilfried De Neve, Sandra Nuyts
PURPOSE/OBJECTIVE: The benefit of upfront neck dissection (ND) in locally advanced head and neck squamous cell carcinoma (HNSCC) treated with primary (chemo-) radiotherapy (R(C)T) is debated. Therefore, we retrospectively compared disease control and toxicity between patients who were treated with and without upfront ND followed by R(C)T. MATERIAL/METHODS: Two-hundred sixty-four consecutive patients with HNSCC without distant metastases at diagnosis and with lymph node stage N2-N3 were included in 2 centers...
July 26, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28751231/concurrent-administration-of-anti-her2-therapy-and-radiotherapy-systematic-review
#19
REVIEW
Fabien Mignot, Zahra Ajgal, Hoping Xu, Arthur Geraud, Jia Yi Chen, Frédérique Mégnin-Chanet, Youlia Kirova
BACKGROUND: Over the past few years, anti-HER2 targeted therapies have proven to be a key treatment in the management of human epidermal growth receptor 2 (HER2)-positive breast cancers, as well as gastrointestinal tract tumors and head and neck tumors. Anti-HER2 therapies administered alone or in combination with chemotherapy have been extensively studied, but only limited robust data are available concerning the safety and efficacy of anti-HER2 molecules in combination with radiotherapy...
July 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28751230/dose-de-escalation-to-the-elective-lymph-nodes-in-head-and-neck-cancer-reply-to-amdur-et-al
#20
LETTER
Daan Nevens, Fréderic Duprez, Jean-François Daisne, Wilfried De Neve, Sandra Nuyts
No abstract text is available yet for this article.
July 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
journal
journal
20234
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"