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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/30241791/treatment-of-brain-metastases-with-stereotactic-radiosurgery-and-immune-checkpoint-inhibitors-an-international-meta-analysis-of-individual-patient-data
#1
Eric J Lehrer, Jennifer Peterson, Paul D Brown, Jason P Sheehan, Alfredo Quiñones-Hinojosa, Nicholas G Zaorsky, Daniel M Trifiletti
BACKGROUND AND PURPOSE: While the combination of stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICI) is becoming more widely used in the treatment of brain metastases (BM), there is a paucity of prospective data to validate both the safety and efficacy, as well as the optimal timing of these two therapies relative to one another. METHODS: A PICOS/PRISMA/MOOSE selection protocol was used to identify 17 studies across 15 institutions in 3 countries...
September 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30241790/in-response-to-rydzewski-nr-et-al-role-of-adjuvant-external-beam-radiotherapy-and-chemotherapy-in-one-versus-two-or-more-node-positive-vulvar-cancer-a-national-cancer-database-study
#2
Jacobus van der Velden, Guus Fons
No abstract text is available yet for this article.
September 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30241789/external-validation-of-an-ntcp-model-for-acute-esophageal-toxicity-in-locally-advanced-nsclc-patients-treated-with-intensity-modulated-chemo-radiotherapy
#3
Frank J W M Dankers, Robin Wijsman, Esther G C Troost, Caroline J A Tissing-Tan, Margriet H Kwint, José Belderbos, Dirk de Ruysscher, Lizza E Hendriks, Lioe-Fee de Geus-Oei, Laura Rodwell, Andre Dekker, René Monshouwer, Aswin L Hoffmann, Johan Bussink
BACKGROUND AND PURPOSE: We externally validated a previously established multivariable normal-tissue complication probability (NTCP) model for Grade ≥2 acute esophageal toxicity (AET) after intensity-modulated (chemo-)radiotherapy or volumetric-modulated arc therapy for locally advanced non-small cell lung cancer. MATERIALS AND METHODS: A total of 603 patients from five cohorts (A-E) within four different Dutch institutes were included. Using the NTCP model, containing predictors concurrent chemoradiotherapy, mean esophageal dose, gender and clinical tumor stage, the risk of Grade ≥2 AET was estimated per patient and model discrimination and (re)calibration performance were evaluated...
September 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30241788/minimum-breast-distance-largely-explains-individual-variability-in-doses-to-contralateral-breast-from-breast-cancer-radiotherapy
#4
Pavel Kundrát, Julia Remmele, Hannes Rennau, Sabine Sebb, Cristoforo Simonetto, Markus Eidemüller, Ulrich Wolf, Guido Hildebrandt
PURPOSE: To provide personalized estimates of doses to contralateral breast (CB) from breast-cancer radiotherapy. METHODS: Whole-breast irradiations using 3D conformal, intensity-modulated and hybrid techniques with 50.4 Gy prescribed dose were planned for 128 breast-cancer patients. From their CT images, 17 anatomic measures were assessed and tested by model fitting as predictors for CB dose-volume characteristics. RESULTS: Multi-field intensity-modulated radiotherapy (IMRT) yielded mean CB doses of 0...
September 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30236994/validation-of-a-novel-molecular-rpa-classification-in-glioblastoma-gbm-molrpa-treated-with-chemoradiation-a-multi-institutional-collaborative-study
#5
Chan Woo Wee, Il Han Kim, Chul-Kee Park, Jin Wook Kim, Yun-Sik Dho, Fumiharu Ohka, Kosuke Aoki, Kazuya Motomura, Atsushi Natsume, Nalee Kim, Chang-Ok Suh, Jong Hee Chang, Se Hoon Kim, Won Kyung Cho, Do Hoon Lim, Do-Hyun Nam, Jung Won Choi, In Ah Kim, Chae-Yong Kim, Young-Taek Oh, Oyeon Cho, Woong-Ki Chung, Sung-Hwan Kim, Eunji Kim
BACKGROUND AND PURPOSE: A novel molecular recursive partitioning analysis classification has recently been reported integrating the MGMT promoter methylation (MGMTmeth) and IDH1 mutation (IDH1mut) status for glioblastoma (GBM-molRPA) patients treated with temozolomide-based chemoradiation. The current study was initiated to validate the model in a multi-institutional study. MATERIALS AND METHODS: Four-hundred seventy-one newly diagnosed GBM patients (validation cohort) were allocated to classes I-III of the previously reported GBM-molRPA model...
September 17, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30224179/a-single-institutional-experience-of-combined-carbon-ion-radiotherapy-and-chemotherapy-for-unresectable-locally-advanced-pancreatic-cancer
#6
Makoto Shinoto, Kotaro Terashima, Hiroaki Suefuji, Akira Matsunobu, Shingo Toyama, Kaori Fukunishi, Yoshiyuki Shioyama
PURPOSE: The aim of this study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for unresectable locally advanced pancreatic cancer (LAPC). METHODS AND MATERIALS: Patients with LAPC treated with definitive C-ion RT between April 2014 and July 2017 were analyzed retrospectively. The prescribed dose was 55.2 Gy (relative biological effectiveness [RBE] weighted absorbed dose) in 12 fractions. Overall survival (OS), local control (LC), progression free survival (PFS), and toxicity were evaluated...
September 14, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30219612/diffusion-weighted-mri-and-adc-versus-fet-pet-and-gdt1w-mri-for-gross-tumor-volume-gtv-delineation-in-re-irradiation-of-recurrent-glioblastoma
#7
Ilinca Popp, Stefan Bott, Michael Mix, Oliver Oehlke, Tanja Schimek-Jasch, Carsten Nieder, Ursula Nestle, Michael Bock, William T C Yuh, Philipp Tobias Meyer, Wolfgang A Weber, Horst Urbach, Irina Mader, Anca-Ligia Grosu
BACKGROUND AND PURPOSE: GTV definition for re-irradiation treatment planning in recurrent glioblastoma (rGBM) is usually based on contrast-enhanced MRI (GdT1w-MRI) and, for an increased specificity, on amino acid PET. Diffusion-weighted (DWI) MRI and ADC maps can reveal regions of high cellularity as surrogate for active tumor. The objective of this study was to compare the localization and quality of diffusion restriction foci (GTV-ADClow) with FET-PET (GTV-PET) and GdT1w-MRI (GTV-GdT1w-MRI)...
September 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30217337/prediction-of-overall-survival-after-re-irradiation-with-stereotactic-body-radiation-therapy-for-pancreatic-cancer-with-a-novel-prognostic-model-the-scad-score
#8
Xiaofei Zhu, Fuqi Li, Xiaoping Ju, Yuxin Shen, Yangsen Cao, Fei Cao, Fang Fang, Shuiwang Qing, Zhen Jia, Huojun Zhang
PURPOSE: To develop a predictive model for stratification of patients with pancreatic cancer who may achieve survival benefits from re-irradiation with stereotactic body radiation therapy (SBRT). METHODS: The score was developed based on clinical predictors of OS in 31 patients receiving two courses of SBRT with Cox proportional hazards model. Results were then validated in another cohort with 11 participants to assess the performance of the score. RESULTS: In the training cohort, the median BED10 of the first and second SBRT was 59...
September 11, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30206021/practical-clinical-guidelines-for-contouring-the-trigeminal-nerve-v-and-its-branches-in-head-and-neck-cancers
#9
Julian Biau, Vincent Dunet, Michel Lapeyre, Christian Simon, Mahmut Ozsahin, Vincent Grégoire, Jean Bourhis
PURPOSE: The trigeminal nerve (V) is a major route of tumor spread in several head and neck cancers. However, only limited data are currently available for its precise contouring, although this is absolutely necessary in the era of intensity-modulated radiation therapy (IMRT). The purpose of this article is to present practical clinical guidelines for contouring the trigeminal nerve (V) in head and neck cancers at risk of spread along this nerve. METHOD: The main types of head and neck cancers associated with risks of spread along the trigeminal nerve (V) and its branches were comprehensively reviewed based on clinical experience, literature-based patterns of failure, anatomy and radio-anatomy...
September 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30206020/a-prospective-longitudinal-assessment-of-mri-signal-intensity-kinetics-of-non-target-muscles-in-patients-with-advanced-stage-oropharyngeal-cancer-in-relationship-to-radiotherapy-dose-and-post-treatment-radiation-associated-dysphagia-preliminary-findings-from
#10
(no author information available yet)
PURPOSE: To assess quantitative signal intensity (SI) kinetics obtained from serial MRI of swallowing muscles as a potential imaging biomarker of radiation-induced dysphagia in oropharyngeal cancer (OPC) patients receiving radiotherapy (RT). METHODS: Patients were enrolled under an IRB approved Phase II/III randomized trial. Patients underwent serial MRIs at pre-, mid-, and post-RT. Normalized T1, T1+ contrast (T1 + C), and T2 SI for swallowing muscle volumes-of-interest (VOIs) were collected and delta SI changes (Δ) were calculated...
September 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30197152/interdisciplinary-training-for-cancer-specialists-the-time-has-come
#11
Niall O'Higgins, Jesper Grau Eriksen, Lynda Wyld, Kim Benstead
No abstract text is available yet for this article.
September 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30193693/good-prognosis-following-a-psa-bounce-after-high-dose-rate-brachytherapy-and-external-radiotherapy-in-prostate-cancer
#12
Lennart Åström, Fredrik Sandin, Lars Holmberg
BACKGROUND: PSA kinetics after curative radiotherapy for prostate cancer is an important part of the posttreatment evaluation. We analysed PSA bounce occurrence after combined high dose rate brachytherapy (HDR-BT) and external radiotherapy (ERT). MATERIAL & METHODS: We analysed 623 patients treated from 1995 to 2008. The median age was 66 years (47-79). The median initial PSA was 12 ng/ml (0.1-224). Neoadjuvant endocrine therapy was given to 429 patients...
September 4, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30190166/comparison-of-three-moderate-fractionated-schedules-employed-in-high-dose-rate-brachytherapy-monotherapy-for-clinically-localized-prostate-cancer
#13
Hideya Yamazaki, Koji Masui, Gen Suzuki, Satoaki Nakamura, Ken Yoshida, Tadayuki Kotsuma, Eiichi Tanaka, Keisuke Otani, Yasuo Yoshioka, Kazuhiko Ogawa
BACKGROUND: Herein, we report the outcomes of 3 schedules of high-dose-rate interstitial brachytherapy (HDR-BT) monotherapy for localized prostate cancer. PATIENTS AND METHODS: A total of 347 patients were treated with 45.5 Gy/7 fractions (n = 86; 45.5 Gy arm, median follow-up time 131 months), 49 Gy/7 fractions (n = 149; 49 Gy arm, 75.9 months), and 54 Gy/9 fractions (n = 112; 54 Gy arm, 68 months). RESULTS: The actuarial 5-year biochemical failure-free survival rates were 86...
September 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30177374/x-rays-can-trigger-the-flash-effect-ultra-high-dose-rate-synchrotron-light-source-prevents-normal-brain-injury-after-whole-brain-irradiation-in-mice
#14
Pierre Montay-Gruel, Audrey Bouchet, Maud Jaccard, David Patin, Raphael Serduc, Warren Aim, Kristoffer Petersson, Benoit Petit, Claude Bailat, Jean Bourhis, Elke Bräuer-Krisch, Marie-Catherine Vozenin
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
August 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30177373/high-resolution-flair-mri-at-7-tesla-for-treatment-planning-in-glioblastoma-patients
#15
Sebastian Regnery, Benjamin R Knowles, Daniel Paech, Nicolas Behl, Jan-Eric Meissner, Paul Windisch, Semi Ben Harrabi, Denise Bernhardt, Heinz-Peter Schlemmer, Mark E Ladd, Stefan Rieken, Jürgen Debus, Sebastian Adeberg
Ultra-high field MRI is an emerging technique promising high-resolution images for radiotherapy planning. We compared a 7 Tesla FLAIR sequence with clinical FLAIR imaging at 3 Tesla in glioblastoma patients before radiotherapy. High-resolution 7 Tesla FLAIR imaging may enhance the depiction of organs at risk and possibly modify target volumes.
August 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30177372/texture-analysis-of-3d-dose-distributions-for-predictive-modelling-of-toxicity-rates-in-radiotherapy
#16
Linda Rossi, Rik Bijman, Wilco Schillemans, Shafak Aluwini, Carlo Cavedon, Marnix Witte, Luca Incrocci, Ben Heijmen
BACKGROUND AND PURPOSE: To explore the use of texture analysis (TA) features of patients' 3D dose distributions to improve prediction modelling of treatment complication rates in prostate cancer radiotherapy. MATERIAL AND METHODS: Late toxicity scores, dose distributions, and non-treatment related (NTR) predictors for late toxicity, such as age and baseline symptoms, of 351 patients of the hypofractionation arm of the HYPRO randomized trial were used in this study...
August 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30177371/a-nomogram-for-predicting-survival-of-patients-with-locally-advanced-pancreatic-cancer-treated-with-chemoradiotherapy
#17
Seo Hee Choi, Seung Woo Park, Jinsil Seong
BACKGROUND: We developed a nomogram for predicting survival of patients with locally advanced pancreatic cancer (LAPC) after concurrent chemoradiotherapy (CRT) using 18 F-flurodeoxyglucose-positron emission tomography (FDG-PET) parameters and CA 19-9 levels. METHODS: Based on 426 patients with LAPC who received concurrent CRT between 2004 and 2015, we investigated significant prognostic factors for survival to build a nomogram, including the maximum standardized uptake value (SUVmax ) and CA 19-9 levels...
August 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30174108/could-radiotherapy-play-a-major-role-in-misidentification-of-sentinel-lymph-node-in-breast-cancer-recurrence
#18
Germana Lissidini, Giuseppe Trifirò, Paolo Veronesi, Chiara Grana, Stefano Zurrida, Viviana Galimberti, Giovanni Corso, Cecilia Vellani, Giovanni B Ivaldi
Misidentification of sentinel lymph node via lymphoscintigraphy for breast cancer is an infrequent event. We analysed 35.022 consecutive procedures from a single institution and tried to find a correlation between failures of sentinel node identification and previous oncologic treatments received by the patients.
August 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30174107/retrospective-evaluation-of-decision-making-for-pancreatic-stereotactic-mr-guided-adaptive-radiotherapy
#19
Marguerite Tyran, Naomi Jiang, Minsong Cao, Ann Raldow, James M Lamb, Daniel Low, Elaine Luterstein, Michael L Steinberg, Percy Lee
BACKGROUND/PURPOSE: Stereotactic-magnetic-resonance-guided-online-adaptive-radiotherapy (SMART) is a promising tool for pancreas stereotactic-body-radiotherapy. Our online-adaptive-radiotherapy (On-ART) process relies on daily image overview by the managing radiation-oncologist, who determines the need for creating a predicted plan if significant interfractional anatomical changes are noted. Predicted plans are achieved through applying the baseline plan on deformed and manually adjusted contours based on daily imaging...
August 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30172457/feasibility-of-markerless-3d-position-monitoring-of-the-central-airways-using-kilovoltage-projection-images-managing-the-risks-of-central-lung-stereotactic-radiotherapy
#20
Colien Hazelaar, Lineke van der Weide, Hassan Mostafavi, Ben J Slotman, Wilko F A R Verbakel, Max Dahele
BACKGROUND AND PURPOSE: Central lung stereotactic body radiotherapy (SBRT) can cause proximal bronchial tree (PBT) toxicity. Information on PBT position relative to the high-dose could aid risk management. We investigated template matching + triangulation for high-frequency markerless 3D PBT position monitoring. MATERIALS AND METHODS: Kilovoltage projections of a moving phantom (full-fan cone-beam CT [CBCT, 15 frames/second] without MV irradiation: 889 images/dataset + CBCT and 7 frames/second fluoroscopy with MV irradiation) and ten patients undergoing free-breathing stereotactic/hypofractionated lung irradiation (full-fan CBCT without MV irradiation, 470-500 images/dataset) were retrospectively analyzed...
August 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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