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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/29150161/improved-pharmacodynamic-pd-assessment-of-low-dose-parp-inhibitor-pd-activity-for-radiotherapy-and-chemotherapy-combination-trials
#1
Rosemarie de Haan, Dick Pluim, Baukelien van Triest, Michel van den Heuvel, Heike Peulen, Damien van Berlo, Jay George, Marcel Verheij, Jan H M Schellens, Conchita Vens
BACKGROUND: PARP inhibitors are currently evaluated in combination with radiotherapy and/or chemotherapy. As sensitizers, PARP inhibitors are active at very low concentrations therefore requiring highly sensitive pharmacodynamic (PD) assays. Current clinical PD-assays partly fail to provide such sensitivities. The aim of our study was to enable sensitive PD evaluation of PARP inhibitors for clinical sensitizer development. MATERIAL AND METHODS: PBMCs of healthy individuals and of olaparib and radiotherapy treated lung cancer patients were collected for ELISA-based PD-assays...
November 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29150160/medical-physics-in-radiation-oncology-new-challenges-needs-and-roles
#2
EDITORIAL
Dietmar Georg, David Thwaites
No abstract text is available yet for this article.
November 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29137808/geometric-and-dosimetric-accuracy-of-dynamic-tumor-tracking-during-volumetric-modulated-arc-therapy-using-a-gimbal-mounted-linac
#3
Tomohiro Ono, Yuki Miyabe, Kunio Takahashi, Mami Akimoto, Nobutaka Mukumoto, Yoshitomo Ishihara, Mitsuhiro Nakamura, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: The aim was to examine the feasibility of a dynamic tumor-tracking volumetric modulated arc therapy (DTT-VMAT) technique using a gimbal-mounted linac and assess its positional, mechanical and dosimetric accuracy. MATERIALS AND METHODS: DTT-VMAT was performed using a surrogated signal-based technique. The positional tracking accuracy was evaluated as the difference between the predicted and detected target positions for various wave patterns. Mechanical accuracy measurements included gantry, multileaf collimator (MLC) and gimbal positions...
November 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29132644/delineating-sites-of-failure-following-post-prostatectomy-radiation-treatment-using-68-ga-psma-pet
#4
Keelan Byrne, Thomas Eade, Andrew Kneebone, Linxin Guo, Ed Hsiao, Geoff Schembri, Carolyn Kwong, Julia Hunter, Louise Emmett, George Hruby
PURPOSE: To identify sites of failure with (68)Ga-PSMA-PET (PSMA-PET) imaging in patients who have Biochemical Failure (BF) following post-prostatectomy radiotherapy. MATERIAL AND METHODS: Between June 2006 and January 2016, 409 men received post prostatectomy intensity modulated radiation treatment (IMRT) with protocolised planning. 310 patients received radiation treatment (RT) to the Prostate Fossa (PF) alone and 99 patients received RT to PF and pelvic lymphatics (PF + LN) usually in combination with androgen deprivation (AD) therapy...
November 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29128167/a-prospective-evaluation-of-hippocampal-radiation-dose-volume-effects-and-memory-deficits-following-cranial-irradiation
#5
Ting Martin Ma, Jimm Grimm, Riley McIntyre, Heather Anderson-Keightly, Lawrence R Kleinberg, Russell K Hales, Joseph Moore, Tracy Vannorsdall, Kristin J Redmond
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone...
November 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29126649/is-dose-de-escalation-possible-in-sarcoma-patients-treated-with-enlarged-limb-sparing-resection
#6
Antonin Levy, Sylvie Bonvalot, Sara Bellefqih, Philippe Terrier, Axel Le Cesne, Cécile Le Péchoux
PURPOSE: To evaluate the impact of dose de-escalation in a large series of resected limbs soft tissue sarcomas (STS). METHODS: Data were retrospectively analysed from 414 consecutive patients treated for limb STS by enlarged surgery and radiotherapy at Gustave Roussy from 05/1993 to 05/2012. Radiotherapy (RT) dose level was decided by the multidisciplinary staff and depended upon the quality of surgery and margins size. RESULTS: RT was delivered prior (13%) or after (87%) surgery...
November 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122363/clustering-of-multi-parametric-functional-imaging-to-identify-high-risk-subvolumes-in-non-small-cell-lung-cancer
#7
Aniek J G Even, Bart Reymen, Matthew D La Fontaine, Marco Das, Felix M Mottaghy, José S A Belderbos, Dirk De Ruysscher, Philippe Lambin, Wouter van Elmpt
BACKGROUND AND PURPOSE: We aimed to identify tumour subregions with characteristic phenotypes based on pre-treatment multi-parametric functional imaging and correlate these subregions to treatment outcome. The subregions were created using imaging of metabolic activity (FDG-PET/CT), hypoxia (HX4-PET/CT) and tumour vasculature (DCE-CT). MATERIALS AND METHODS: 36 non-small cell lung cancer (NSCLC) patients underwent functional imaging prior to radical radiotherapy...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122362/with-or-without-consolidation-chemotherapy-using-cisplatin-5-fu-after-concurrent-chemoradiotherapy-in-stage-ii-iii-squamous-cell-carcinoma-of-the-esophagus-a-propensity-score-matched-analysis
#8
Yongshun Chen, Liying Guo, Xinyu Cheng, Jun Wang, Yougai Zhang, Yi Wang, Shaobo Ke, Wei Shi
BACKGROUND AND PURPOSE: The benefit of consolidation chemotherapy for locally advanced squamous cell carcinoma of the esophagus is unknown. The aim of this study was to investigate the efficacy of consolidation chemotherapy with cisplatin and 5-fluorouracil (5-FU) after concurrent chemoradiotherapy (CCRT) with the same agents in patients with stage II-III disease. MATERIAL AND METHODS: Data for patients with stage II-III squamous cell carcinoma of the esophagus treated with CCRT were retroactively reviewed...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122361/ventilation-measured-on-clinical-4d-cbct-increased-ventilation-accuracy-through-improved-image-quality
#9
Kasper R Jensen, Carsten Brink, Olfred Hansen, Uffe Bernchou
BACKGROUND AND PURPOSE: Ventilation measured on 4D cone-beam computed tomography (CBCT) using deformable image registration (DIR) may predict specific radiation sensitivity, but the measurement is affected by the current image quality. With 4D computed tomography (CT) measured ventilation acting as a gold standard the current study investigates if image improvements increase the accuracy of 4D-CBCT measured ventilation. MATERIAL AND METHODS: The study consists of 4D-CBCT and 4D-CT scans of 20 non-small-cell lung cancer patients...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122360/association-between-treatment-planning-and-delivery-factors-and-disease-progression-in-prostate-cancer-radiotherapy-results-from-the-trog-03-04-radar-trial
#10
Marco Marcello, Martin Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, David Joseph, James Denham
BACKGROUND AND PURPOSE: To evaluate the impact of treatment planning and delivery factors on treatment outcome as measured by post-treatment disease progression. MATERIALS AND METHODS: Accruing 813 external beam radiotherapy participants during 2003-2007, the RADAR trial collected a comprehensive range of clinical treatment factor data for each participant. Both the Fine and Gray competing risks modelling and the Kaplan-Meier (KM) analysis were undertaken to determine the impact of these factors on local-composite progression (LCP), with 709 participants available for analysis...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122359/prognostic-impact-of-rita-expression-in-patients-with-anal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#11
Franz Rödel, Kerstin Steinhäuser, Nina-Naomi Kreis, Alexandra Friemel, Daniel Martin, Ulrike Wieland, Margret Rave-Fränk, Panagiotis Balermpas, Emmanouil Fokas, Frank Louwen, Claus Rödel, Juping Yuan
BACKGROUND: RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. MATERIALS AND METHODS: In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS)...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29122358/post-radiochemotherapy-pet-radiomics-in-head-and-neck-cancer-the-influence-of-radiomics-implementation-on-the-reproducibility-of-local-control-tumor-models
#12
Marta Bogowicz, Ralph T H Leijenaar, Stephanie Tanadini-Lang, Oliver Riesterer, Martin Pruschy, Gabriela Studer, Jan Unkelbach, Matthias Guckenberger, Ender Konukoglu, Philippe Lambin
PURPOSE: This study investigated an association of post-radiochemotherapy (RCT) PET radiomics with local tumor control in head and neck squamous cell carcinoma (HNSCC) and evaluated the models against two radiomics software implementations. MATERIALS AND METHODS: 649 features, available in two radiomics implementations and based on the same definitions, were extracted from HNSCC primary tumor region in 18F-FDG PET scans 3 months post definitive RCT (training cohort n = 128, validation cohort n = 50) and compared using the intraclass correlation coefficient (ICC)...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29113697/sensitivity-of-a-prompt-gamma-slit-camera-to-detect-range-shifts-for-proton-treatment-verification
#13
Lena Nenoff, Marlen Priegnitz, Guillaume Janssens, Johannes Petzoldt, Patrick Wohlfahrt, Anna Trezza, Julien Smeets, Guntram Pausch, Christian Richter
BACKGROUND AND PURPOSE: A prompt-gamma imaging (PGI) slit-camera was recently applied successfully in clinical proton treatments using pencil beam scanning (PBS) and double scattering (DS). However, its full capability under clinical conditions has still to be systematically evaluated. Here, the performance of the slit-camera is systematically assessed in well-defined error scenarios using realistic treatment deliveries to an anthropomorphic head phantom. MATERIALS AND METHODS: The sensitivity and accuracy to detect introduced global and local range shifts with the slit-camera was investigated in PBS and DS irradiations...
November 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29108779/whole-body-total-lesion-glycolysis-is-an-independent-predictor-in-patients-with-esophageal-cancer-treated-with-definitive-chemoradiotherapy
#14
Noriyoshi Takahashi, Rei Umezawa, Kentaro Takanami, Takaya Yamamoto, Youjirou Ishikawa, Maiko Kozumi, Kazuya Takeda, Noriyuki Kadoya, Keiichi Jingu
BACKGROUND AND PURPOSE: To determine whether pretreatment whole-body total lesion glycolysis (TLGWB) and metabolic tumor volume (MTVWB) are associated with outcomes in patients with esophageal cancer treated with definitive chemoradiotherapy (dCRT). MATERIALS AND METHODS: Ninety patients with stage II or III thoracic esophageal cancer who underwent FDG-PET/CT within 45 days before dCRT between 2005 and 2013 were reviewed. MTV and TLG of the primary lesion (MTVpri and TLGpri) and the sum of MTV and TLG for all lesions (MTVWB and TLGWB) were calculated...
November 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29103826/impact-of-dose-intensified-salvage-radiation-therapy-on-urinary-continence-recovery-after-radical-prostatectomy-results-of-the-randomized-trial-sakk-09-10
#15
Pirus Ghadjar, Stefanie Hayoz, Jürg Bernhard, Daniel R Zwahlen, Jürgen Stein, Tobias Hölscher, Philipp Gut, Bülent Polat, Guido Hildebrandt, Arndt-Christian Müller, Paul Martin Putora, Alexandros Papachristofilou, Corinne Schär, Alan Dal Pra, Christine Biaggi Rudolf, Peter Wust, Daniel M Aebersold, George N Thalmann
INTRODUCTION: Adjuvant radiation therapy (aRT) after radical prostatectomy (RP) is associated with impaired urinary continence recovery as compared to surveillance. Less is known regarding the effect of salvage radiation therapy (sRT) dose intensification on continence outcomes. MATERIALS AND METHODS: Urinary continence recovery was investigated within a multicentre randomized trial in biochemically recurrent prostate cancer patients who received either 64 Gy (32 fractions) or 70 Gy (35 fractions) sRT...
November 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29100701/robustness-of-patient-positioning-for-interfractional-error-in-carbon-ion-radiotherapy-for-stage-i-lung-cancer-bone-matching-versus-tumor-matching
#16
Makoto Sakai, Yoshiki Kubota, Jun-Ichi Saitoh, Daisuke Irie, Katsuyuki Shirai, Ryosuke Okada, Masami Torikoshi, Tatsuya Ohno, Takashi Nakano
BACKGROUND AND PURPOSE: Patient positioning was compared by tumor matching (TM) and conventional bony structure matching (BM) in carbon ion radiotherapy for stage I non-small cell lung cancer to evaluate the robustness of TM and BM in determining interfractional error. MATERIAL AND METHODS: Sixty irradiation fields were analyzed. Computed tomography (CT) images acquired before treatment initiation for confirmation (Conf-CT) were obtained under the same settings as the treatment planning CT images and used to evaluate both positioning methods...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29100700/prognostic-impact-of-hpv-associated-p16-expression-and-smoking-status-on-outcomes-following-radiotherapy-for-oropharyngeal-cancer-the-march-hpv-project
#17
Pernille Lassen, Benjamin Lacas, Jean-Pierre Pignon, Andy Trotti, Bjorn Zackrisson, Qiang Zhang, Jens Overgaard, Pierre Blanchard
BACKGROUND AND PURPOSE: Evaluate the prognostic and predictive impact of HPV-associated p16-expression and assess the combined prognostic impact of p16 and smoking on altered fractionated radiotherapy (AFRT) for oropharyngeal cancer (OPC) within the frames of the update of the Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH). MATERIALS AND METHODS: Patients with OPC, known tumor p16-status and smoking history were identified from the MARCH update, resulting in a dataset of 815 patients from four randomized trials (RTOG9003, DAHANCA6&7, RTOG0129, ARTSCAN)...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29100699/glucose-starvation-impairs-dna-repair-in-tumour-cells-selectively-by-blocking-histone-acetylation
#18
Rena Ampferl, Hans Peter Rodemann, Claus Mayer, Tobias Tim Alexander Höfling, Klaus Dittmann
BACKGROUND AND PURPOSE: Tumour cells are characterized by aerobic glycolysis and thus have high glucose consumption. Because repairing radiation-induced DNA damage is an energy-demanding process, we hypothesized that glucose starvation combined with radiotherapy could be an effective strategy to selectively target tumour cells. MATERIAL AND METHODS: We glucose-starved tumour cells (A549, FaDu) in vitro and analysed their radiation-induced cell responses compared to normal fibroblasts (HSF7)...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29100698/a-virtual-dosimetry-audit-towards-transferability-of-gamma-index-analysis-between-clinical-trial-qa-groups
#19
Mohammad Hussein, Enrico Clementel, David J Eaton, Peter B Greer, Annette Haworth, Satoshi Ishikura, Stephen F Kry, Joerg Lehmann, Jessica Lye, Angelo F Monti, Mitsuhiro Nakamura, Coen Hurkmans, Catharine H Clark
PURPOSE: Quality assurance (QA) for clinical trials is important. Lack of compliance can affect trial outcome. Clinical trial QA groups have different methods of dose distribution verification and analysis, all with the ultimate aim of ensuring trial compliance. The aim of this study was to gain a better understanding of different processes to inform future dosimetry audit reciprocity. MATERIALS: Six clinical trial QA groups participated. Intensity modulated treatment plans were generated for three different cases...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29100697/automated-reference-free-local-error-assessment-of-multimodal-deformable-image-registration-for-radiotherapy-in-the-head-and-neck
#20
Michael G Nix, Robin J D Prestwich, Richard Speight
BACKGROUND: Head and neck MR-CT deformable image registration (DIR) for radiotherapy planning is hindered by the lack of both ground-truth and per-patient accuracy assessment methods. This study assesses novel post-registration reference-free error assessment algorithms, based on local rigid re-registration of native and pseudomodality images. METHODS: Head and neck MR obtained in and out of the treatment position underwent DIR to planning CT. Block-wise mutual information (b-MI) and pseudomodality mutual information (b-pmMI) algorithms were validated against applied rotations and translations...
October 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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