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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/30414759/patterns-of-proton-therapy-use-in-pediatric-cancer-management-in-2016-an-international-survey
#1
Neige Journy, Daniel J Indelicato, Diana R Withrow, Tetsuo Akimoto, Claire Alapetite, Masayuki Araya, Andrew Chang, John Han-Chih Chang, Brian Chon, Michael E Confer, Yusuke Demizu, Rémi Dendale, Jérôme Doyen, Ralph Ermoian, Kristin Gurtner, Christine Hill-Kayser, Hiromitsu Iwata, Joo-Young Kim, Young Kwok, Nadia N Laack, Choonsik Lee, Do Hoon Lim, Lilia Loredo, Victor S Mangona, David B Mansur, Masao Murakami, Shigeyuki Murayama, Takashi Ogino, Barbora Ondrová, Rahul R Parikh, Arnold C Paulino, Stephanie Perkins, Naren R Ramakrishna, Ronald Richter, Barbara Rombi, Satoshi Shibata, Shinichi Shimizu, Beate Timmermann, Tamara Vern-Gross, Chiachien J Wang, Damien C Weber, John Ben Wilkinson, Petra Witt Nyström, Torunn I Yock, Ruth A Kleinerman, Amy Berrington de Gonzalez
PURPOSE: To facilitate the initiation of observational studies on late effects of proton therapy in pediatric patients, we report on current patterns of proton therapy use worldwide in patients aged less than 22 years. MATERIALS & METHODS: Fifty-four proton centers treating pediatric patients in 2016 in 11 countries were invited to respond to a survey about the number of patients treated during that year by age group, intent of treatment, delivery technique and tumor types...
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30414758/epoetin-receptor-status-may-alter-the-outcomes-in-head-and-neck-cancers-treated-with-radiotherapy-and-darbepoetin-%C3%AE
#2
LETTER
Erkan Topkan, Berna Akkus Yildirim
No abstract text is available yet for this article.
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30414757/early-outcomes-of-breast-cancer-patients-treated-with-post-mastectomy-uniform-scanning-proton-therapy
#3
Leo Luo, John Cuaron, Lior Braunstein, Erin Gillespie, Atif Kahn, Beryl McCormick, Dennis Mah, Brian Chon, Henry Tsai, Simon Powell, Oren Cahlon
BACKGROUND: Postmastectomy proton radiotherapy improves normal tissue sparing in comparison to photon-based approaches. Several studies have reported dosimetry comparison and tolerable acute toxicity profile with limited follow-up. We report our institutional experience of postmastectomy proton radiation including clinical efficacy and toxicities. METHODS: From December 2013 to February 2015, 42 consecutive patients who received mastectomy for non-metastatic breast cancer were treated with adjuvant chest wall and regional nodal proton therapy at a single proton center...
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30414756/delineation-guideline-for-the-para-aortic-lymph-node-region-in-cervical-cancer-clarification-letter
#4
LETTER
Lorna G Keenan, Orla McArdle
No abstract text is available yet for this article.
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30414755/persistent-reduction-in-global-longitudinal-strain-in-the-longer-term-after-radiation-therapy-in-patients-with-breast-cancer
#5
Siddharth J Trivedi, Preeti Choudhary, Queenie Lo, Hari Prakash Sritharan, Arvind Iyer, Vikneswary Batumalai, Geoff P Delaney, Liza Thomas
BACKGROUND: More than 80% of breast cancer patients receive radiotherapy (RT). However, RT can lead to cardiotoxicity, which usually develops insidiously over years, making diagnosis difficult. It is also unknown whether early identification of at-risk patients might improve long-term outcome. We have previously described subclinical alterations, detected by two-dimensional speckle tracking strain echocardiography, in left ventricular (LV) function immediately following RT in breast cancer...
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30414754/predictive-factors-for-survival-of-oligometastatic-colorectal-cancer-treated-with-stereotactic-body-radiation-therapy
#6
Ciro Franzese, Tiziana Comito, Eno Toska, Angelo Tozzi, Elena Clerici, Fiorenza De Rose, Davide Franceschini, Pierina Navarria, Giacomo Reggiori, Stefano Tomatis, Marta Scorsetti
BACKGROUND AND PURPOSE: Colorectal cancer (CRC) represents one of the major leading causes of death from cancer. Aim of the present study was to analyze outcome of oligometastatic CRC patients treated with stereotactic body radiation therapy (SBRT), and to evaluate predictive factors of survival. MATERIALS AND METHODS: We included patients with maximum 5 metastases. Previous/concomitant systemic treatments were allowed. End points of the present study were the outcome in terms of Local control of treated metastases (LC), progression free survival (PFS), and overall survival (OS)...
November 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30392781/improving-outcomes-in-non-small-cell-lung-cancer-population-analysis-of-radical-radiotherapy
#7
Michael Brada, Christine Ball, Susan Mitchell, Helen Forbes, Susan Ashley
AIM: Regional utilisation of radical radiotherapy (RT) in non-small cell lung cancer (NSCLC) was used to define optimal utilisation to improve outcome and as a surrogate for evidence of RT efficacy. PATIENTS & METHODS: 65,412 NSCLC cases diagnosed in England 2012-13 were linked to comprehensive national radiotherapy dataset, hospital admissions and the Office of National Statistics. Geographical variation in utilisation was determined using a multivariate binary logistic regression analysis after adjusting for age, stage, deprivation, comorbidity and other radical treatment and the effect of radical RT utilisation on survival was investigated...
November 1, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30392780/deep-learning-provides-a-new-computed-tomography-based-prognostic-biomarker-for-recurrence-prediction-in-high-grade-serous-ovarian-cancer
#8
Shuo Wang, Zhenyu Liu, Yu Rong, Bin Zhou, Yan Bai, Wei Wei, Wei Wei, Meiyun Wang, Yingkun Guo, Jie Tian
BACKGROUND AND PURPOSE: Recurrence is the main risk for high-grade serous ovarian cancer (HGSOC) and few prognostic biomarkers were reported. In this study, we proposed a novel deep learning (DL) method to extract prognostic biomarkers from preoperative computed tomography (CT) images, aiming at providing a non-invasive recurrence prediction model in HGSOC. MATERIALS AND METHODS: We enrolled 245 patients with HGSOC from two hospitals, which included a feature-learning cohort (n = 102), a primary cohort (n = 49) and two independent validation cohorts from two hospitals (n = 49 and n = 45)...
November 1, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30391106/stereotactic-body-radiotherapy-with-adjuvant-systemic-therapy-for-early-stage-non-small-cell-lung-carcinoma-a-multi-institutional-analysis
#9
Benjamin H Kann, Joseph A Miccio, John M Stahl, Rudi Ross, Vivek Verma, Arie P Dosoretz, Henry S Park, Timothy D Shafman, Cary P Gross, James B Yu, Roy H Decker
PURPOSE: Although adjuvant systemic therapy (ST) is often recommended for the treatment of patients with high-risk, early-stage non-small cell lung carcinoma (NSCLC) after surgery, there is little evidence supporting the use of ST with stereotactic body radiotherapy (SBRT). METHODS: We conducted a retrospective cohort study using a multi-institutional database to identify consecutive patients with T1-3N0M0 NSCLC treated with definitive SBRT from 2006-2015. Treatment groups were defined as those who received SBRT + ST or SBRT alone...
October 31, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30389241/ten-year-survival-after-high-dose-rate-brachytherapy-combined-with-external-beam-radiation-therapy-in-high-risk-prostate-cancer-a-comparison-with-the-norwegian-spcg-7-cohort
#10
Trude B Wedde, Milada C Småstuen, Sigmund Brabrand, Sophie D Fosså, Stein Kaasa, Gunnar Tafjord, Kjell M Russnes, Taran P Hellebust, Wolfgang Lilleby
BACKGROUND: The survival benefit of dose-escalation with High-Dose-Rate brachytherapy (HDR-BT) boost combined with External Beam Radiotherapy (EBRT) for the treatment of high-risk prostate cancer (PCa) remains debatable. We investigated 10-year PCa-specific mortality (PCSM) and overall mortality (OM) in high-risk patients treated with HDR-BT/EBRT (calculated EQD2 = 102 Gy) compared to EBRT alone (70 Gy). METHODS: HDR-BT boosts (10 Gy × 2) were given 2 weeks apart followed by 50 Gy conformal EBRT (2 Gy × 25) to the prostate and seminal vesicles...
October 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30389240/are-hypothyroidism-and-hypogonadism-clinically-relevant-in-patients-with-malignant-gliomas-a-longitudinal-trial-in-patients-with-glioma
#11
Ammon Handisurya, Tamara Rumpold, Carola Caucig-Lütgendorf, Birgit Flechl, Matthias Preusser, Aysegül Ilhan-Mutlu, Karin Dieckmann, Georg Widhalm, Anna Grisold, Adelheid Wöhrer, Johannes Hainfellner, Robin Ristl, Christine Kurz, Christine Marosi, Alois Gessl, Marco Hassler
BACKGROUND: So far, the development and course of therapy-induced deficiencies in hypothalamic-pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient's quality of life substantially. METHODS: In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion...
October 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30389239/greater-reduction-in-mid-treatment-fdg-pet-volume-may-be-associated-with-worse-survival-in-non-small-cell-lung-cancer
#12
Feng-Ming Spring Kong, Ling Li, Weili Wang, Jeff Campbell, Jennifer L Waller, Morand Piert, Milton Gross, Monica Cheng, Dawn Owen, Matthew Stenmark, Ke Colin Huang, Kirk A Frey, Randall K Ten Haken, Theodore S Lawrence
BACKGROUND AND PURPOSE: This study tested the hypotheses that 1) changes in mid-treatment fluorodeoxyglucose (FDG)-positron emission tomography (PET) parameters are predictive of overall survival (OS) and 2) mid-treatment FDG-PET-adapted treatment has the potential to improve survival in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Patients with stage I-III NSCLC requiring daily fractionated radiation were eligible. FDG-PET-CT scans were obtained prior to and mid-treatment with radiotherapy at 40-50 Gy...
October 30, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30385173/community-approach-for-reducing-small-field-measurement-errors-experience-over-24-centres
#13
Cinzia Talamonti, Serenella Russo, Maria Pimpinella, Maria Daniela Falco, Elisabetta Cagni, Stefania Pallotta, Michele Stasi, Pietro Mancosu
PURPOSE: The complexity of the modern Stereotactic Body Radiation Therapy (SBRT) techniques requires comprehensive quality assurance programs, to ensure the right treatment to the patient. Dosimetry of small radiation fields is a challenge especially for radiotherapy centres starting to work on this issue. The matter to be discussed here concerns the need of detailed measurement procedures and cross checks to be paired to the usual recommendations on detectors and correction factors. MATERIALS AND METHODS: The presented work involved 24 Italian radiotheraphy centres, with the specific purpose to minimize systematic errors in output factor measurements over different radiotherapy centres...
October 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30385172/predicting-severe-acute-radiation-pneumonitis-in-patients-with-non-small-cell-lung-cancer-receiving-postoperative-radiotherapy-development-and-internal-validation-of-a-nomogram-based-on-the-clinical-and-dose-volume-histogram-parameters
#14
Xin Tang, Yanying Li, Xue Tian, Xiaojuan Zhou, Yongsheng Wang, Meijuan Huang, Li Ren, Lin Zhou, Jianxin Xue, Zhenyu Ding, Jiang Zhu, Yong Xu, Feng Peng, Jin Wang, You Lu, Youling Gong
BACKGROUND AND PURPOSE: Postoperative radiotherapy (PORT) can potentially lead to radiation pneumonitis. We aim to develop a nomogram predicting the severe acute radiation pneumonitis (SARP, grade ≥3) in patients with non-small cell lung cancer (NSCLC) receiving PORT. MATERIALS AND METHODS: Clinical and dose-volume histogram (DVH) factors were collected from 109 patients between 2006 and 2017. The endpoint was the development of SARP within 3 months after PORT...
October 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30381141/total-neoadjuvant-treatment-capox-plus-radiotherapy-for-patients-with-locally-advanced-rectal-cancer-with-high-risk-factors-a-phase-2-trial
#15
Xin Wang, Yongyang Yu, Wenjian Meng, Dan Jiang, Xiangbing Deng, Bing Wu, Hua Zhuang, Cun Wang, Yali Shen, Lie Yang, Hong Zhu, Ke Cheng, Yaqin Zhao, Zhiping Li, Memg Qiu, Hongfeng Gou, Feng Bi, Feng Xu, Rrenmin Zhong, Sen Bai, Ziqiang Wang, Zongguang Zhou
BACKGROUND AND PURPOSE: To evaluate the safety and efficacy of Total neoadjuvant treatment (TNT) in patients with rectal cancer with high risk factors. METHODS AND MATERIALS: We did this phase 2 trial in patients who were diagnosed with stage II-III rectal cancer with at least one of the high risk factors. Three cycles of induction CAPOX were followed by pelvic radiotherapy of 50.4 Gy/28 fractions and two cycles of concurrent CAPOX. Three cycles of consolidation CAPOX were delivered after radiotherapy...
October 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30366726/a-feasibility-study-of-high-dose-hypofractionated-carbon-ion-radiation-therapy-using-four-fractions-for-localized-hepatocellular-carcinoma-measuring-3-cm-or-larger
#16
Kei Shibuya, Tatsuya Ohno, Hiroyuki Katoh, Masahiko Okamoto, Shintaro Shiba, Yoshinori Koyama, Satoru Kakizaki, Ken Shirabe, Takashi Nakano
BACKGROUND AND PURPOSE: To evaluate the safety of carbon-ion radiotherapy (C-ion RT) using 60 Gy (relative biological effectiveness, RBE) in four fractions for patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The primary outcome was acute toxicities within 90 days. The secondary outcomes were late toxicities, local control, and progression-free survival and overall survival rates. The key inclusion criteria were as follows: (1) 3 cm or larger HCC without major vascular invasion and not adjacent to the alimentary tract; (2) Child-Pugh's grade A/B; and (3) without extrahepatic metastasis...
October 23, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30366725/prognostic-value-of-gross-tumor-regression-and-plasma-epstein-barr-virus-dna-levels-at-the-end-of-intensity-modulated-radiation-therapy-in-patients-with-nasopharyngeal-carcinoma
#17
Shao-Bo Liang, Ning Zhang, Dan-Ming Chen, Xing-Li Yang, Bin-Hong Chen, Hai Zhao, Rui-Liang Lu, Yong Chen, Li-Wu Fu
PURPOSE: To assess gross tumor regression and plasma Epstein-Barr virus (EBV)-DNA levels at the end of intensity-modulated radiation therapy (IMRT) and its prognostic impact on patients with nasopharyngeal carcinoma (NPC). PARTICIPANTS AND METHODS: In total, 397 patients with non-metastatic, histologically confirmed NPC were retrospectively examined. All patients underwent magnetic resonance imaging of the nasopharynx and neck, and plasma EBV DNA assays before treatment and at the end of IMRT...
October 23, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30360998/carbon-ion-radiotherapy-for-locally-recurrent-rectal-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1404-rectum
#18
Makoto Shinoto, Shigeru Yamada, Masahiko Okamoto, Yoshiyuki Shioyama, Tatsuya Ohno, Takashi Nakano, Kenji Nemoto, Yuka Isozaki, Shohei Kawashiro, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: We investigated the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally recurrent rectal cancer (LRRC). PATIENTS AND METHODS: Data from patients with LRRC treated with C-ion RT from November 2003 to December 2014 at three institutions were retrospectively analyzed. The endpoints of this clinical trial were overall survival (OS), local control (LC), and acute/late toxicity. RESULTS: A total of 224 patients' data were collected...
October 22, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30360997/letter-to-the-editor-of-radiotherapy-and-oncology-regarding-the-paper-entitled-prospective-data-registration-and-clinical-trials-for-particle-therapy-by-langendijk-et-al
#19
Anne Laprie, Valérie Bernier, Christian Carrie
No abstract text is available yet for this article.
October 22, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/30348462/analysis-of-eortc-1219-dahanca-29-trial-plans-demonstrates-the-potential-of-knowledge-based-planning-to-provide-patient-specific-treatment-plan-quality-assurance
#20
Jim P Tol, Max Dahele, Vincent Gregoire, Jens Overgaard, Ben J Slotman, Wilko F A R Verbakel
INTRODUCTION: Radiotherapy treatment plan quality can influence clinical trial outcomes and general QA may not identify suboptimal organ-at-risk (OAR) sparing. We retrospectively performed patient-specific quality assurance (QA) of 100 head-and-neck cancer (HNC) plans from the EORTC-1219-DAHANCA-29 study. MATERIALS AND METHODS: A 177-patient RapidPlan (Varian Medical Systems) model comprising institutional HNC plans was used to QA trial plans (Ptrial ). RapidPlan plans (Prapidplan ) were created using RapidPlan and Eclipse scripting to achieve a high degree of automation...
October 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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