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Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology

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https://www.readbyqxmd.com/read/28551110/the-pattern-of-cervical-lymph-node-metastasis-in-thoracic-esophageal-squamous-cell-carcinoma-may-affect-the-target-decision-for-definitive-radiotherapy
#1
Junqiang Chen, WenJie Cai, Xiongwei Zheng, Yuanmei Chen, Yu Lin, Xiaohui Chen, Kunshou Zhu, Chuanben Chen
BACKGROUND: Metastasis to lymph nodes is a key determinant of thoracic esophageal squamous cell carcinoma (TE-SCC) prognosis. We sought to identify factors linked with cervical lymph node metastasis, which could be used to inform the decision of surgical and definitive radiotherapy. METHODS: We retrospectively reviewed records from 1715 patients who had had radical esophagectomy with three-field lymphadenectomy between January 1993 and March 2007 in our hospital...
May 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28549794/intensity-modulated-proton-therapy-and-osteoradionecrosis-in-oropharyngeal-cancer
#2
Wencheng Zhang, Xiaodong Zhang, Pei Yang, Pierre Blanchard, Adam S Garden, Brandon Gunn, C David Fuller, Mark Chambers, Katherine A Hutcheson, Rong Ye, Stephen Y Lai, Mohamed Abdallah Sherif Radwan, X Ron Zhu, Steven J Frank
PURPOSE: We compared mandibular doses and osteoradionecrosis in patients with oropharyngeal cancer after intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT). METHODS AND MATERIALS: We identified 584 patients who received definitive radiotherapy for oropharyngeal cancer from January 2011 through June 2014 at MD Anderson Cancer Center (534 IMRT and 50 IMPT). The dosimetric variables and osteoradionecrosis were compared with Chi-square test or Fisher's exact test...
May 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28545958/efficacy-of-postoperative-radiation-treatment-for-bone-metastases-in-the-extremities
#3
Leah Drost, Vithusha Ganesh, Bo Angela Wan, Srinivas Raman, Stephanie Chan, Monique Christakis, May Tsao, Elizabeth Barnes, Michael Ford, Joel Finkelstein, Albert Yee, Angela Turner, Henry Lam, Edward Chow
BACKGROUND AND PURPOSE: Impending or pathological fractures due to bone metastases may require surgical fixation. Postoperative radiation is often recommended to reduce local progression and prevent prosthesis displacement, hence reducing the need for second surgery. The objectives of this study were to investigate the need for second surgery, and to report on rates of re-irradiation, tumor progression and prosthesis displacement following postoperative radiation. MATERIALS AND METHODS: Data were collected from 65 patients who received postoperative radiation to 74 sites in the extremities in a palliative radiation clinic between January 2009 and January 2017...
May 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28545957/irradiation-in-a-flash-unique-sparing-of-memory-in-mice-after-whole-brain-irradiation-with-dose-rates-above-100gy-s
#4
Pierre Montay-Gruel, Kristoffer Petersson, Maud Jaccard, Gaël Boivin, Jean-François Germond, Benoit Petit, Raphaël Doenlen, Vincent Favaudon, François Bochud, Claude Bailat, Jean Bourhis, Marie-Catherine Vozenin
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.
May 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28545956/comparison-of-particle-beam-therapy-and-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-a-systematic-review-and-hypothesis-generating-meta-analysis
#5
REVIEW
Alexander Chi, Haiquan Chen, Sijin Wen, Haijuan Yan, Zhongxing Liao
PURPOSE: To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified through extensive searches of the PubMed, Medline, Google-scholar, and Cochrane library databases from 2000 to 2016. Original English publications of ES NSCLC were included. A meta-analysis was performed to compare the survival outcome, toxicity profile, and patterns of failure following each treatment...
May 22, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532609/risk-factors-for-osteonecrosis-of-the-jaw-in-oral-cancer-patients-after-surgery-and-eventual-adjuvant-treatment-the-potential-role-of-chemotherapy
#6
Tzu-Yu Lai, Ti-Hao Wang, Chia-Jen Liu, Tze-Fan Chao, Tzeng-Ji Chen, Yu-Wen Hu
BACKGROUND AND PURPOSE: To identify the risk factors for osteonecrosis of the jaw (ONJ) in oral cancer patients after surgery with and without adjuvant therapy in a nationwide, population-based study. MATERIAL AND METHODS: Using the Taiwan National Health Insurance Research Dataset, we recruited patients with newly diagnosed oral cancer between 1997 and 2011. All of them underwent primary surgery. Data regarding demographic characteristics; tooth extractions; medications; and cancer treatments, including types of mandibular surgery, radiotherapy and platinum-based chemotherapy, were collected for analysis...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#7
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532607/three-dimensional-intrafractional-internal-target-motions-in-accelerated-partial-breast-irradiation-using-three-dimensional-conformal-external-beam-radiotherapy
#8
Kimiko Hirata, Michio Yoshimura, Nobutaka Mukumoto, Mitsuhiro Nakamura, Minoru Inoue, Makoto Sasaki, Takahiro Fujimoto, Shinsuke Yano, Manabu Nakata, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: We evaluated three-dimensional intrafractional target motion, divided into respiratory-induced motion and baseline drift, in accelerated partial breast irradiation (APBI). METHODS: Paired fluoroscopic images were acquired simultaneously using orthogonal kV X-ray imaging systems at pre- and post-treatment for 23 patients who underwent APBI with external beam radiotherapy. The internal target motion was calculated from the surgical clips placed around the tumour cavity...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532606/verifying-tumor-position-during-stereotactic-body-radiation-therapy-delivery-using-limited-arc-cone-beam-computed-tomography-imaging
#9
Colien Hazelaar, Max Dahele, Stefan Scheib, Ben J Slotman, Wilko F A R Verbakel
BACKGROUND AND PURPOSE: Proof of tumor position during stereotactic body radiotherapy (SBRT) delivery is desirable. We investigated if cone-beam CT (CBCT) scans reconstructed from (collimated) fluoroscopic kV images acquired during irradiation could show the dominant tumor position. MATERIALS AND METHODS: Full-arc CBCT scans were reconstructed using FDK filtered back projection from 38kV fluoroscopy datasets (16 patients) continuously acquired during volumetric modulated spine SBRT...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532605/risk-of-hypothyroidism-among-patients-with-nasopharyngeal-carcinoma-treated-with-radiation-therapy-a-population-based-cohort-study
#10
Chao-Yueh Fan, Chun-Shu Lin, Hsing-Lung Chao, Wen-Yen Huang, Yu-Fu Su, Kuen-Tze Lin, I-Ju Tsai, Chia-Hung Kao
BACKGROUND AND PURPOSE: This study aimed to assess the incidence and risk of hypothyroidism among patients with nasopharyngeal carcinoma (NPC) after radiation therapy (RT). MATERIAL AND METHODS: We identified 14,893 NPC patients and 16,105 other head and neck cancer (HNC) patients treated with RT without thyroidectomy from the National Health Insurance Research Database in Taiwan between 2000 and 2011. Each NPC patient was randomly frequency-matched with four individuals without NPC by age, sex, and index year...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28528680/prognostic-factors-of-adenoid-cystic-carcinoma-of-the-head-and-neck-in-carbon-ion-radiotherapy-the-impact-of-histological-subtypes
#11
Hiroaki Ikawa, Masashi Koto, Ryo Takagi, Daniel K Ebner, Azusa Hasegawa, Kensuke Naganawa, Toshinao Takenouchi, Toshitaka Nagao, Takeshi Nomura, Takahiko Shibahara, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). MATERIAL AND METHODS: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern...
May 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28528018/in-reply-to-chang-et-al-contouring-guidelines-for-post-mastectomy-radiotherapy-a-cry-for-international-consensus
#12
LETTER
John A Vargo, Sushil Beriwal
No abstract text is available yet for this article.
May 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28511960/inadequate-target-volume-delineation-and-local-regional-recurrence-after-intensity-modulated-radiotherapy-for-human-papillomavirus-positive-oropharynx-cancer
#13
Allen M Chen, Robert Chin, Philip Beron, Taeko Yoshizaki, Argin G Mikaeilian, Minsong Cao
PURPOSE: To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS AND MATERIALS: The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset...
May 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28506693/survival-prediction-of-non-small-cell-lung-cancer-patients-using-radiomics-analyses-of-cone-beam-ct-images
#14
Janna E van Timmeren, Ralph T H Leijenaar, Wouter van Elmpt, Bart Reymen, Cary Oberije, René Monshouwer, Johan Bussink, Carsten Brink, Olfred Hansen, Philippe Lambin
BACKGROUND AND PURPOSE: In this study we investigated the interchangeability of planning CT and cone-beam CT (CBCT) extracted radiomic features. Furthermore, a previously described CT based prognostic radiomic signature for non-small cell lung cancer (NSCLC) patients using CBCT based features was validated. MATERIAL AND METHODS: One training dataset of 132 and two validation datasets of 62 and 94stage I-IV NSCLC patients were included. Interchangeability was assessed by performing a linear regression on CT and CBCT extracted features...
May 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28502473/salvage-radiation-therapy-after-prostatectomy-understanding-the-dose-response-effect
#15
LETTER
Claudio Fiorino, Sara Broggi, Nadia Gisella Di Muzio, Nicola Fossati, Alberto Briganti, Cesare Cozzarini
No abstract text is available yet for this article.
May 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28502472/a-novel-concept-for-tumour-targeting-with-radiation-inverse-dose-painting-or-targeting-the-low-drug-uptake-volume
#16
Ala Yaromina, Marlies Granzier, Rianne Biemans, Natasja Lieuwes, Wouter van Elmpt, Georgy Shakirin, Ludwig Dubois, Philippe Lambin
BACKGROUND AND PURPOSE: We tested a novel treatment approach combining (1) targeting radioresistant hypoxic tumour cells with the hypoxia-activated prodrug TH-302 and (2) inverse radiation dose-painting to boost selectively non-hypoxic tumour sub-volumes having no/low drug uptake. MATERIAL AND METHODS: (18)F-HX4 hypoxia tracer uptake measured with a clinical PET/CT scanner was used as a surrogate of TH-302 activity in rhabdomyosarcomas growing in immunocompetent rats...
May 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28499607/evaluation-of-intensity-modulated-radiation-therapy-dose-painting-for-localized-prostate-cancer-using-68-ga-hbed-cc-psma-pet-ct-a-planning-study-based-on-histopathology-reference
#17
Constantinos Zamboglou, Ilias Sachpazidis, Khodor Koubar, Vanessa Drendel, Rolf Wiehle, Simon Kirste, Michael Mix, Florian Schiller, Panayiotis Mavroidis, Philipp T Meyer, Martin Werner, Anca L Grosu, Dimos Baltas
PURPOSE: To demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of IMRT dose painting using (68)Ga-HBED-CC PSMA PET/CT for target delineation in prostate cancer (PCa). METHODS AND MATERIALS: 10 patients had PSMA PET/CT scans prior to prostatectomy. GTV-PET was generated on the basis of an intraprostatic SUVmax of 30%. Two IMRT plans were generated for each patient: Plan(77) which consisted of whole-prostate IMRT to 77Gy, and Plan(95) which consisted of whole-prostate IMRT to 77Gy and a simultaneous integrated boost to the GTV-PET up to 95Gy (35 fractions)...
May 9, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28483302/preoperative-chemoradiotherapy-for-rectal-cancer-and-impact-on-outcomes-a-population-based-study
#18
Linn M Åsli, Tom B Johannesen, Tor Å Myklebust, Bjørn Møller, Morten Tandberg Eriksen, Marianne Grønlie Guren
BACKGROUND AND PURPOSE: Preoperative (chemo)radiotherapy ((C)RT) for rectal cancer is, in Norway, restricted to patients with cT4-stage or threatened circumferential resection margin. This nationwide population-based study assessed the use of preoperative (C)RT in Norway and its impact on treatment outcomes. PATIENTS AND METHODS: Data from The Norwegian Colorectal Cancer Registry were used to identify all stage I-III rectal cancers treated with major resection (1997-2011: n=9193)...
May 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28478912/quality-assurance-of-radiotherapy-in-the-ongoing-eortc-1219-dahanca-29-trial-for-hpv-p16-negative-squamous-cell-carcinoma-of-the-head-and-neck-results-of-the-benchmark-case-procedure
#19
Melissa Christiaens, Sandra Collette, Jens Overgaard, Vincent Gregoire, Joanna Kazmierska, Pierre Castadot, Jordi Giralt, Warren Grant, Milan Tomsej, Raquel Bar-Deroma, Angelo F Monti, Coen Wilhelm Hurkmans, Damien Charles Weber
BACKGROUND AND PURPOSE: The phase III EORTC 1219-DAHANCA 29 intergroup trial evaluates the influence of nimorazole in patients with locally advanced head and neck cancer when treated with accelerated radiotherapy (RT) in combination with chemotherapy. This article describes the results of the RT Benchmark Case (BC) performed before patient inclusion. MATERIALS AND METHODS: The participating centers were asked to perform a 2-step BC, consisting of (1) a delineation and (2) a planning exercise according to the protocol guidelines...
May 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28477972/first-clinical-investigation-of-a-4d-maximum-likelihood-reconstruction-for-4d-pet-based-treatment-verification-in-ion-beam-therapy
#20
Chiara Gianoli, Elisabetta De Bernardi, Rosalinda Ricotti, Christopher Kurz, Julia Bauer, Marco Riboldi, Guido Baroni, Jürgen Debus, Katia Parodi
BACKGROUND AND PURPOSE: In clinical applications of Positron Emission Tomography (PET)-based treatment verification in ion beam therapy (PT-PET), detection and interpretation of inconsistencies between Measured PET and Expected PET are mostly limited by Measured PET noise, due to low count statistics, and by Expected PET bias, especially due to inaccurate washout modelling in off-line implementations. In this work, a recently proposed 4D Maximum Likelihood (ML) reconstruction algorithm which considers Measured PET and Expected PET as two different motion phases of a 4D dataset is assessed on clinical 4D PET-CT datasets acquired after carbon ion therapy...
May 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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