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Radiology

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https://www.readbyqxmd.com/read/28339311/lung-rads-category-4x-does-it-improve-prediction-of-malignancy-in-subsolid-nodules
#1
Kaman Chung, Colin Jacobs, Ernst T Scholten, Jin Mo Goo, Helmut Prosch, Nicola Sverzellati, Francesco Ciompi, Onno M Mets, Paul K Gerke, Mathias Prokop, Bram van Ginneken, Cornelia M Schaefer-Prokop
Purpose To evaluate the added value of Lung CT Screening Reporting and Data System (Lung-RADS) assessment category 4X over categories 3, 4A, and 4B for differentiating between benign and malignant subsolid nodules (SSNs). Materials and Methods SSNs on all baseline computed tomographic (CT) scans from the National Lung Cancer Trial that would have been classified as Lung-RADS category 3 or higher were identified, resulting in 374 SSNs for analysis. An experienced screening radiologist volumetrically segmented all solid cores and located all malignant SSNs visible on baseline scans...
March 24, 2017: Radiology
https://www.readbyqxmd.com/read/28327002/use-of-imaging-to-predict-complete-response-of-colorectal-liver-metastases-after-chemotherapy-mr-imaging-versus-ct-imaging
#2
Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi-Suk Park
Purpose To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrast-enhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled...
March 22, 2017: Radiology
https://www.readbyqxmd.com/read/28318403/familial-cerebral-cavernous-malformations-are-associated-with-adrenal-calcifications-on-ct-scans-an-imaging-biomarker-for-a-hereditary-cerebrovascular-condition
#3
Corinne D Strickland, Steven C Eberhardt, Mary R Bartlett, Jeffrey Nelson, Helen Kim, Leslie A Morrison, Blaine L Hart
Purpose To determine if adrenal calcifications seen at computed tomography (CT) are associated with familial cerebral cavernous malformations (fCCMs) in carriers of the CCM1 Common Hispanic Mutation. Materials and Methods This study was approved by the institutional review board. The authors retrospectively reviewed abdominal CT scans in 38 patients with fCCM, 38 unaffected age- and sex-matched control subjects, and 13 patients with sporadic, nonfamilial cerebral cavernous malformation (CCM). The size, number, and laterality of calcifications and the morphologic characteristics of the adrenal gland were recorded...
March 20, 2017: Radiology
https://www.readbyqxmd.com/read/28318404/magnetization-transfer-imaging-of-treatment-resistant-depression
#4
Zhiyun Jia, Wei Peng, Ziqi Chen, Huaiqiang Sun, Huawei Zhang, Weihong Kuang, Xiaoqi Huang, Su Lui, Qiyong Gong
Purpose To detect biophysical abnormalities in patients with postmedication treatment-resistant depression (TRD) with magnetization transfer imaging. Materials and Methods This study was approved by the local ethics committee, and written informed consent was obtained from all participants. Participants included 69 patients with major depressive disorder (MDD) (30 with TRD; 39 with non-TRD) and 41 healthy control subjects. Age and sex were examined with one-way analysis of variance and χ(2) tests and were well matched among the three groups...
March 17, 2017: Radiology
https://www.readbyqxmd.com/read/28301779/detection-of-bone-marrow-edema-in-nondisplaced-hip-fractures-utility-of-a-virtual-unenhanced-dual-energy-ct-application
#5
Trenton T Kellock, Savvas Nicolaou, Sandra S Y Kim, Sultan Al-Busaidi, Luck J Louis, Tim W O'Connell, Hugue A Ouellette, Patrick D McLaughlin
Purpose To quantify the sensitivity and specificity of dual-energy computed tomographic (CT) virtual noncalcium images in the detection of nondisplaced hip fractures and to assess whether obtaining these images as a complement to bone reconstructions alters sensitivity, specificity, or diagnostic confidence. Materials and Methods The clinical research ethics board approved chart review, and the requirement to obtain informed consent was waived. The authors retrospectively identified 118 patients who presented to a level 1 trauma center emergency department and who underwent dual-energy CT for suspicion of a nondisplaced traumatic hip fracture...
March 16, 2017: Radiology
https://www.readbyqxmd.com/read/28301778/risk-stratified-versus-non-risk-stratified-diagnostic-testing-for-management-of-suspected-acute-biliary-obstruction-comparative-effectiveness-costs-and-the-role-of-mr-cholangiopancreatography
#6
Stella K Kang, David Hoffman, Bart Ferket, Michelle I Kim, R Scott Braithwaite
Purpose To analyze the cost effectiveness of the American Society for Gastrointestinal Endoscopy (ASGE) risk stratification guidelines versus magnetic resonance (MR) cholangiopancreatography-based treatment of patients with possible choledocholithiasis. Materials and Methods A decision-analytic model was constructed to compare cost and effectiveness of three diagnostic strategies for gallstone disease with possible choledocholithiasis: noncontrast MR cholangiopancreatography, contrast material-enhanced MR imaging/MR cholangiopancreatography, and ASGE risk stratification guidelines for diagnostic evaluation recommending endoscopy (high risk), MR cholangiopancreatography (intermediate risk), or no test (low risk)...
March 16, 2017: Radiology
https://www.readbyqxmd.com/read/28301777/vertebral-body-compression-fractures-and-bone-density-automated-detection-and-classification-on-ct-images
#7
Joseph E Burns, Jianhua Yao, Ronald M Summers
Purpose To create and validate a computer system with which to detect, localize, and classify compression fractures and measure bone density of thoracic and lumbar vertebral bodies on computed tomographic (CT) images. Materials and Methods Institutional review board approval was obtained, and informed consent was waived in this HIPAA-compliant retrospective study. A CT study set of 150 patients (mean age, 73 years; age range, 55-96 years; 92 women, 58 men) with (n = 75) and without (n = 75) compression fractures was assembled...
March 16, 2017: Radiology
https://www.readbyqxmd.com/read/28301311/extracranial-soft-tissue-tumors-repeatability-of-apparent-diffusion-coefficient-estimates-from-diffusion-weighted-mr-imaging
#8
Jessica M Winfield, Nina Tunariu, Mihaela Rata, Keiko Miyazaki, Neil P Jerome, Michael Germuska, Matthew D Blackledge, David J Collins, Johann S de Bono, Timothy A Yap, Nandita M deSouza, Simon J Doran, Dow-Mu Koh, Martin O Leach, Christina Messiou, Matthew R Orton
Purpose To assess the repeatability of apparent diffusion coefficient (ADC) estimates in extracranial soft-tissue diffusion-weighted magnetic resonance imaging across a wide range of imaging protocols and patient populations. Materials and Methods Nine prospective patient studies and one prospective volunteer study, performed between 2006 and 2016 with research ethics committee approval and written informed consent from each subject, were included in this single-institution study. A total of 141 tumors and healthy organs were imaged twice (interval between repeated examinations, 45 minutes to 10 days, depending the on study) to assess the repeatability of median and mean ADC estimates...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28301310/glass-fiber-based-mr-safe-guidewire-for-mr-imaging-guided-endovascular-interventions-in-vitro-and-preclinical-in-vivo-feasibility-study
#9
Alexander Massmann, Arno Buecker, Guenther K Schneider
Purpose To evaluate glass-fiber-based guidewires that are safe for magnetic resonance (MR) imaging-guided endovascular interventions by using a phantom and an in vivo swine model. Materials and Methods MR imaging-safe guidewires were made from micropultruded glass and/or aramid fibers and epoxy resin with diameters of 0.89 mm (0.035 inch) for standard and stiff guidewires and 0.36 mm (0.014 inch) for micro guidewires. MR imaging visibility and mechanical properties were assessed in a pulsatile flow model. After approval was obtained from the institutional animal care and use committee, MR imaging guidewires were evaluated for standard endovascular procedures in nine pigs...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28301309/value-of-dynamic-contrast-enhanced-and-diffusion-weighted-mr-imaging-in-the-detection-of-pathologic-complete-response-in-cervical-cancer-after-neoadjuvant-therapy-a-retrospective-observational-study
#10
Aurélie Jalaguier-Coudray, Rim Villard-Mahjoub, Aurélie Delouche, Béatrice Delarbre, Eric Lambaudie, Gilles Houvenaeghel, Mathieu Minsat, Agnès Tallet, Renaud Sabatier, Isabelle Thomassin-Naggara
Purpose To evaluate the association between dynamic contrast material-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance (MR) imaging with pathologic complete response after preoperative combined chemotherapy and radiation therapy for cervical carcinoma and evaluate the risk of local recurrence. Materials and Methods The institutional ethics committee approved the study and waived the requirement to obtain informed consent. The study comprised 52 patients with locally advanced carcinoma, treated first with combined chemotherapy and radiation therapy, who underwent MR imaging before final surgery between June 2011 and July 2015...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28290782/prognostic-value-of-combined-ct-angiography-and-myocardial-perfusion-imaging-versus-invasive-coronary-angiography-and-nuclear-stress-perfusion-imaging-in-the-prediction-of-major-adverse-cardiovascular-events-the-core320-multicenter-study
#11
Marcus Y Chen, Carlos E Rochitte, Armin Arbab-Zadeh, Marc Dewey, Richard T George, Julie M Miller, Hiroyuki Niinuma, Kunihiro Yoshioka, Kakuya Kitagawa, Hajime Sakuma, Roger Laham, Andrea L Vavere, Rodrigo J Cerci, Vishal C Mehra, Cesar Nomura, Klaus F Kofoed, Masahiro Jinzaki, Sachio Kuribayashi, Arthur J Scholte, Michael Laule, Swee Yaw Tan, John Hoe, Narinder Paul, Frank J Rybicki, Jeffrey A Brinker, Andrew E Arai, Matthew B Matheson, Christopher Cox, Melvin E Clouse, Marcelo F Di Carli, João A C Lima
Purpose To compare the prognostic importance (time to major adverse cardiovascular event [MACE]) of combined computed tomography (CT) angiography and CT myocardial stress perfusion imaging with that of combined invasive coronary angiography (ICA) and stress single photon emission CT myocardial perfusion imaging. Materials and Methods This study was approved by all institutional review boards, and written informed consent was obtained. Between November 2009 and July 2011, 381 participants clinically referred for ICA and aged 45-85 years were enrolled in the Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Row Computed Tomography (CORE320) prospective multicenter diagnostic study...
March 14, 2017: Radiology
https://www.readbyqxmd.com/read/28287917/does-reader-performance-with-digital-breast-tomosynthesis-vary-according-to-experience-with-two-dimensional-mammography
#12
Lorraine Tucker, Fiona J Gilbert, Susan M Astley, Amanda Dibden, Archana Seth, Juliet Morel, Sara Bundred, Janet Litherland, Herman Klassen, Gerald Lip, Hema Purushothaman, Hilary M Dobson, Linda McClure, Philippa Skippage, Katherine Stoner, Caroline Kissin, Ursula Beetles, Yit Yoong Lim, Emma Hurley, Jane Goligher, Rumana Rahim, Tanja J Gagliardi, Tamara Suaris, Stephen W Duffy
Purpose To assess whether individual reader performance with digital breast tomosynthesis (DBT) and two-dimensional (2D) mammography varies with number of years of experience or volume of 2D mammograms read. Materials and Methods After written informed consent was obtained, 8869 women (age range, 29-85 years; mean age, 56 years) were recruited into the TOMMY trial (A Comparison of Tomosynthesis with Digital Mammography in the UK National Health Service Breast Screening Program), an ethically approved, multicenter, multireader, retrospective reading study, between July 2011 and March 2013...
March 13, 2017: Radiology
https://www.readbyqxmd.com/read/28287916/the-effect-of-contrast-medium-on-radiation-dose-in-ct-part-ii-a-systematic-evaluation-across-58-patient-models
#13
Pooyan Sahbaee, Ehsan Abadi, W Paul Segars, Daniele Marin, Rendon C Nelson, Ehsan Samei
Purpose To estimate the radiation dose as a result of contrast medium administration in a typical abdominal computed tomographic (CT) examination across a library of contrast material-enhanced computational patient models. Materials and Methods In part II of this study, first, the technique described in part I of this study was applied to enhance the extended cardiac-torso models with patient-specific iodine-time profiles reflecting the administration of contrast material. Second, the patient models were deployed to assess the patient-specific organ dose as a function of time in a typical abdominal CT examination using Monte Carlo simulation...
March 13, 2017: Radiology
https://www.readbyqxmd.com/read/28281908/increasing-navigation-speed-at-endoluminal-ct-colonography-reduces-colonic-visualization-and-polyp-identification
#14
Andrew A Plumb, Peter Phillips, Graeme Spence, Susan Mallett, Stuart A Taylor, Steve Halligan, Thomas Fanshawe
Purpose To investigate the effect of increasing navigation speed on the visual search and decision making during polyp identification for computed tomography (CT) colonography Materials and Methods Institutional review board permission was obtained to use deidentified CT colonography data for this prospective reader study. After obtaining informed consent from the readers, 12 CT colonography fly-through examinations that depicted eight polyps were presented at four different fixed navigation speeds to 23 radiologists...
March 10, 2017: Radiology
https://www.readbyqxmd.com/read/28278002/quantifying-abdominal-adipose-tissue-and-thigh-muscle-volume-and-hepatic-proton-density-fat-fraction-repeatability-and-accuracy-of-an-mr-imaging-based-semiautomated-analysis-method
#15
Michael S Middleton, William Haufe, Jonathan Hooker, Magnus Borga, Olof Dahlqvist Leinhard, Thobias Romu, Patrik Tunón, Gavin Hamilton, Tanya Wolfson, Anthony Gamst, Rohit Loomba, Claude B Sirlin
Purpose To determine the repeatability and accuracy of a commercially available magnetic resonance (MR) imaging-based, semiautomated method to quantify abdominal adipose tissue and thigh muscle volume and hepatic proton density fat fraction (PDFF). Materials and Methods This prospective study was institutional review board- approved and HIPAA compliant. All subjects provided written informed consent. Inclusion criteria were age of 18 years or older and willingness to participate. The exclusion criterion was contraindication to MR imaging...
March 9, 2017: Radiology
https://www.readbyqxmd.com/read/28273007/pediatric-brain-no-increased-signal-intensity-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-consecutive-exposure-to-a-macrocyclic-gadolinium-based-contrast-agent
#16
Alexander Radbruch, Robert Haase, Philipp Kickingereder, Philipp Bäumer, Sebastian Bickelhaupt, Daniel Paech, Wolfgang Wick, Heinz-Peter Schlemmer, Angelika Seitz, Martin Bendszus
Purpose To determine the effect of at least five serial injections of the macrocyclic gadolinium-based contrast agent (GBCA) gadoterate meglumine on the signal intensity (SI) of the dentate nucleus (DN) of the pediatric brain on nonenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 41 pediatric patients (age range, 3-17 years) who were imaged in at least five consecutive 1.5-T MR examinations with the exclusive use of gadoterate meglumine (plus a final additional nonenhanced MR imaging examination) were evaluated...
March 8, 2017: Radiology
https://www.readbyqxmd.com/read/28263701/early-sorafenib-related-biomarkers-for-combination-treatment-with-transarterial-chemoembolization-and-sorafenib-in-patients-with-hepatocellular-carcinoma
#17
Bin-Yan Zhong, Cai-Fang Ni, Li Chen, Hai-Dong Zhu, Gao-Jun Teng
Purpose To identify early biomarkers for the prediction of the therapeutic response in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) and sorafenib (referred to as TACE plus sorafenib) and establish an effective prognostic nomogram. Materials and Methods The study was approved by the institutional ethics review boards at both participating centers. This retrospective study included all patients with HCC who underwent TACE plus sorafenib therapy between January 2010 and December 2013 at two institutions...
March 6, 2017: Radiology
https://www.readbyqxmd.com/read/28263700/standard-reduced-and-no-dose-thin-section-radiologic-examinations-comparison-of-capability-for-nodule-detection-and-nodule-type-assessment-in-patients-suspected-of-having-pulmonary-nodules
#18
Yoshiharu Ohno, Hisanobu Koyama, Takeshi Yoshikawa, Yuji Kishida, Shinichiro Seki, Daisuke Takenaka, Masao Yui, Mitsue Miyazaki, Kazuro Sugimura
Purpose To compare the capability of pulmonary thin-section magnetic resonance (MR) imaging with ultrashort echo time (UTE) with that of standard- and reduced-dose thin-section computed tomography (CT) in nodule detection and evaluation of nodule type. Materials and Methods The institutional review board approved this study, and written informed consent was obtained from each patient. Standard- and reduced-dose chest CT (60 and 250 mA) and MR imaging with UTE were used to examine 52 patients; 29 were men (mean age, 66...
March 6, 2017: Radiology
https://www.readbyqxmd.com/read/28253108/ischemia-induces-quiescence-and-autophagy-dependence-in-hepatocellular-carcinoma
#19
Terence P F Gade, Elizabeth Tucker, Michael S Nakazawa, Stephen J Hunt, Waihay Wong, Bryan Krock, Charles N Weber, Gregory J Nadolski, Timothy W I Clark, Michael C Soulen, Emma E Furth, Jeffrey D Winkler, Ravi K Amaravadi, M Celeste Simon
Purpose To characterize hepatocellular carcinoma (HCC) cells surviving ischemia with respect to cell cycle kinetics, chemosensitivity, and molecular dependencies that may be exploited to potentiate treatment with transarterial embolization (TAE). Materials and Methods Animal studies were performed according to institutionally approved protocols. The growth kinetics of HCC cells were studied in standard and ischemic conditions. Viability and cell cycle kinetics were measured by using flow cytometry. Cytotoxicity profiling was performed by using a colorimetric cell proliferation assay...
March 2, 2017: Radiology
https://www.readbyqxmd.com/read/28253107/incidence-outcomes-and-predictors-of-ventricular-thrombus-after-reperfused-st-segment-elevation-myocardial-infarction-by-using-sequential-cardiac-mr-imaging
#20
Esther Cambronero-Cortinas, Clara Bonanad, Jose V Monmeneu, María Pilar Lopez-Lereu, Jose Gavara, Elena de Dios, Cesar Rios, Nerea Perez, Paolo Racugno, Ana Paya, David Escribano, Gema Minana, Mauricio Pellicer, Joaquim Cànoves, Julio Nunez, Francisco J Chorro, David Moratal, Vicente Bodi
Purpose To characterize the incidence, outcomes, and predictors of left ventricular (LV) thrombus by using sequential cardiac magnetic resonance (MR) imaging after ST-segment-elevation myocardial infarction (STEMI). Materials and Methods Written informed consent was obtained from all patients, and the study protocol was approved by the committee on human research. In a cohort of 772 patients with STEMI, 392 (mean age, 58 years; range, 24-89 years) were retrospectively selected who were studied with cardiac MR imaging at 1 week and 6 months...
March 2, 2017: Radiology
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