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Radiology

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https://www.readbyqxmd.com/read/27925871/no-signal-intensity-increase-in-the-dentate-nucleus-on-unenhanced-t1-weighted-mr-images-after-more-than-20-serial-injections-of-macrocyclic-gadolinium-based-contrast-agents
#1
Alexander Radbruch, Robert Haase, Pascal J Kieslich, Lukas D Weberling, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
Purpose To determine the effect of more than 20 serial injections of macrocyclic gadolinium-based contrast agents (GBCAs) on the signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 33 patients who underwent at least 20 consecutive MR imaging examinations (plus an additional MR imaging for reference) with the exclusive use of macrocyclic GBCAs gadoterate meglumine and gadobutrol were analyzed...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27924721/structural-brain-connectome-and-cognitive-impairment-in-parkinson-disease
#2
Sebastiano Galantucci, Federica Agosta, Elka Stefanova, Silvia Basaia, Martijn P van den Heuvel, Tanja Stojković, Elisa Canu, Iva Stanković, Vladana Spica, Massimiliano Copetti, Delia Gagliardi, Vladimir S Kostić, Massimo Filippi
Purpose To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. Materials and Methods This prospective study was approved by the local ethics committees, and written informed consent was obtained from all subjects prior to enrollment. The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27924720/n-terminal-pro-b-type-natriuretic-peptide-and-subclinical-brain-damage-in-the-general-population
#3
Hazel I Zonneveld, M Arfan Ikram, Albert Hofman, Wiro J Niessen, Aad van der Lugt, Gabriel P Krestin, Oscar H Franco, Meike W Vernooij
Purpose To investigate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is a marker of heart disease, and markers of subclinical brain damage on magnetic resonance (MR) images in community-dwelling middle-aged and elderly subjects without dementia and without a clinical diagnosis of heart disease. Materials and Methods This prospective population-based cohort study was approved by a medical ethics committee overseen by the national government, and all participants gave written informed consent...
December 7, 2016: Radiology
https://www.readbyqxmd.com/read/27918707/national-performance-benchmarks-for-modern-screening-digital-mammography-update-from-the-breast-cancer-surveillance-consortium
#4
Constance D Lehman, Robert F Arao, Brian L Sprague, Janie M Lee, Diana S M Buist, Karla Kerlikowske, Louise M Henderson, Tracy Onega, Anna N A Tosteson, Garth H Rauscher, Diana L Miglioretti
Purpose To establish performance benchmarks for modern screening digital mammography and assess performance trends over time in U.S. community practice. Materials and Methods This HIPAA-compliant, institutional review board-approved study measured the performance of digital screening mammography interpreted by 359 radiologists across 95 facilities in six Breast Cancer Surveillance Consortium (BCSC) registries. The study included 1 682 504 digital screening mammograms performed between 2007 and 2013 in 792 808 women...
December 5, 2016: Radiology
https://www.readbyqxmd.com/read/27918709/spectral-photon-counting-ct-initial-experience-with-dual-contrast-agent-k-edge-colonography
#5
Daniela Muenzel, Daniel Bar-Ness, Ewald Roessl, Ira Blevis, Matthias Bartels, Alexander A Fingerle, Stefan Ruschke, Philippe Coulon, Heiner Daerr, Felix K Kopp, Bernhard Brendel, Axel Thran, Michal Rokni, Julia Herzen, Loic Boussel, Franz Pfeiffer, Roland Proksa, Ernst J Rummeny, Philippe Douek, Peter B Noël
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by using the characteristic k edge of gadolinium. Materials and Methods A custom-made colon phantom was filled with nonionic iodine-based contrast material, and a gadolinium-filled capsule representing a contrast material-enhanced polyp was positioned on the colon wall. The colon phantom was scanned with a preclinical spectral photon-counting CT system to obtain spectral and conventional data...
December 2, 2016: Radiology
https://www.readbyqxmd.com/read/27918708/patient-specific-hip-fracture-strength-assessment-with-microstructural-mr-imaging-based-finite-element-modeling
#6
Chamith S Rajapakse, Alexandra Hotca, Benjamin T Newman, Austin Ramme, Shaleen Vira, Elizabeth A Kobe, Rhiannon Miller, Stephen Honig, Gregory Chang
Purpose To describe a nonlinear finite element analysis method by using magnetic resonance (MR) images for the assessment of the mechanical competence of the hip and to demonstrate the reproducibility of the tool. Materials and Methods This prospective study received institutional review board approval and fully complied with HIPAA regulations for patient data. Written informed consent was obtained from all subjects. A nonlinear finite element analysis method was developed to estimate mechanical parameters that relate to hip fracture resistance by using MR images...
December 2, 2016: Radiology
https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#7
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27892781/analysis-and-prediction-of-claustrophobia-during-mr-imaging-with-the-claustrophobia-questionnaire-an-observational-prospective-18-month-single-center-study-of-6500-patients
#8
Adriane E Napp, Judith Enders, Robert Roehle, Gerd Diederichs, Matthias Rief, Elke Zimmermann, Peter Martus, Marc Dewey
Purpose To analyze claustrophobia during magnetic resonance (MR) imaging and to explore the potential of the 26-item claustrophobia questionnaire (CLQ) (range, 0-4) as a screening tool in patients scheduled for MR imaging. Materials and Methods The study received institutional review board approval, and patients in the CLQ cohort provided informed consent. A total of 6520 consecutive patients were included. Overall, 4288 patients completed the CLQ before MR imaging (CLQ cohort), and 2232 patients underwent MR imaging without having completed the CLQ (non-CLQ cohort)...
November 25, 2016: Radiology
https://www.readbyqxmd.com/read/27875106/neoadjuvant-systemic-therapy-in-breast-cancer-association-of-contrast-enhanced-mr-imaging-findings-diffusion-weighted-imaging-findings-and-tumor-subtype-with-tumor-response
#9
Gorane Santamaría, Xavier Bargalló, Pedro Luis Fernández, Blanca Farrús, Xavier Caparrós, Martin Velasco
Purpose To investigate the performance of tumor subtype and various magnetic resonance (MR) imaging parameters in the assessment of tumor response to neoadjuvant systemic therapy (NST) in patients with breast cancer and to outline a model of pathologic response, considering pathologic complete response (pCR) as the complete absence of any residual invasive cancer or ductal carcinoma in situ (DCIS). Materials and Methods This was an institutional review board-approved retrospective study, with waiver of the need to obtain informed consent...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27875105/renal-cell-carcinoma-comparison-of-renal-nephrometry-and-padua-scores-with-maximum-tumor-diameter-for-prediction-of-local-recurrence-after-thermal-ablation
#10
Aaron W P Maxwell, Grayson L Baird, Jason D Iannuccilli, William W Mayo-Smith, Damian E Dupuy
Purpose To evaluate the performance of the radius, exophytic or endophytic, nearness to collecting system or sinus, anterior or posterior, and location relative to polar lines (RENAL) nephrometry and preoperative aspects and dimensions used for anatomic classification (PADUA) scoring systems and other tumor biometrics for prediction of local tumor recurrence in patients with renal cell carcinoma after thermal ablation. Materials and Methods This HIPAA-compliant study was performed with a waiver of informed consent after institutional review board approval was obtained...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27875104/ct-guided-native-medical-renal-biopsy-cortical-tangential-versus-non-tangential-approaches-a-comparison-of-efficacy-and-safety
#11
Bo Liu, Matthew O'Dell, Miguel Flores, Joseph Limback, Melissa Kendall, Julie Pepe, Jeremy R Burt, Francisco Contreras, Andrew R Lewis, Thomas J Ward
Purpose To review a single-center experience with the cortical tangential approach during computed tomography (CT)-guided native medical renal biopsy and to evaluate its efficacy and safety compared with those of a non-cortical tangential approach. Materials and Methods This retrospective study received institutional review board approval, with a waiver of the HIPAA requirement for informed consent. The number of cores, glomeruli, and complications were reviewed in 431 CT-guided medical renal biopsies performed between July 2007 and September 2015...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27875103/diffusion-weighted-imaging-as-a-treatment-response-biomarker-for-evaluating-bone-metastases-in-prostate-cancer-a-pilot-study
#12
Raquel Perez-Lopez, Joaquin Mateo, Helen Mossop, Matthew D Blackledge, David J Collins, Mihaela Rata, Veronica A Morgan, Alison Macdonald, Shahneen Sandhu, David Lorente, Pasquale Rescigno, Zafeiris Zafeiriou, Diletta Bianchini, Nuria Porta, Emma Hall, Martin O Leach, Johann S de Bono, Dow-Mu Koh, Nina Tunariu
Purpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials and Methods A phase II prospective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCRPC included a prospective magnetic resonance (MR) imaging substudy; the study was approved by the institutional research board, and written informed consent was obtained...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27861111/diagnostic-performance-of-mr-elastography-and-vibration-controlled-transient-elastography-in-the-detection-of-hepatic-fibrosis-in-patients-with-severe-to-morbid-obesity
#13
Jun Chen, Meng Yin, Jayant A Talwalkar, Jennifer Oudry, Kevin J Glaser, Thomas C Smyrk, Véronique Miette, Laurent Sandrin, Richard L Ehman
Purpose To evaluate the diagnostic performance and examination success rate of magnetic resonance (MR) elastography and vibration-controlled transient elastography (VCTE) in the detection of hepatic fibrosis in patients with severe to morbid obesity. Materials and Methods This prospective and HIPAA-compliant study was approved by the institutional review board. A total of 111 patients (71 women, 40 men) participated. Written informed consent was obtained from all patients. Patients underwent MR elastography with two readers and VCTE with three observers to acquire liver stiffness measurements for liver fibrosis assessment...
November 18, 2016: Radiology
https://www.readbyqxmd.com/read/27861110/in-bore-3-t-mr-guided-transrectal-targeted-prostate-biopsy-prostate-imaging-reporting-and-data-system-version-2-based-diagnostic-performance-for-detection-of-prostate-cancer
#14
Nelly Tan, Wei-Chan Lin, Pooria Khoshnoodi, Nazanin H Asvadi, Jeffrey Yoshida, Daniel J A Margolis, David S K Lu, Holden Wu, Kyung Hyun Sung, David Y Lu, Jaioti Huang, Steven S Raman
Purpose To determine the diagnostic yield of in-bore 3-T magnetic resonance (MR) imaging-guided prostate biopsy and stratify performance according to Prostate Imaging Reporting and Data System (PI-RADS) versions 1 and 2. Materials and Methods This study was HIPAA compliant and institution review board approved. In-bore 3-T MR-guided prostate biopsy was performed in 134 targets in 106 men who (a) had not previously undergone prostate biopsy, (b) had prior negative biopsy findings with increased prostate-specific antigen (PSA) level, or (c) had a prior history of prostate cancer with increasing PSA level...
November 18, 2016: Radiology
https://www.readbyqxmd.com/read/27849434/less-invasive-phenotype-found-in-isocitrate-dehydrogenase-mutated-glioblastomas-than-in-isocitrate-dehydrogenase-wild-type-glioblastomas-a-diffusion-tensor-imaging-study
#15
Stephen J Price, Kieren Allinson, Hongxiang Liu, Natalie R Boonzaier, Jiun-Lin Yan, Victoria C Lupson, Timothy J Larkin
Purpose To explore the diffusion-tensor (DT) imaging-defined invasive phenotypes of both isocitrate dehydrogenase (IDH-1)-mutated and IDH-1 wild-type glioblastomas. Materials and Methods Seventy patients with glioblastoma were prospectively recruited and imaged preoperatively. All patients provided signed consent, and the local research ethics committee approved the study. Patients underwent surgical resection, and tumor samples underwent immunohistochemistry for IDH-1 R132H mutations. DT imaging data were coregistered to the anatomic magnetic resonance study and reconstructed to provide the anisotropic and isotropic components of the DT...
November 16, 2016: Radiology
https://www.readbyqxmd.com/read/27849433/differential-regulation-of-macrophage-glucose-metabolism-by-macrophage-colony-stimulating-factor-and-granulocyte-macrophage-colony-stimulating-factor-implications-for-18-f-fdg-pet-imaging-of-vessel-wall-inflammation
#16
Sina Tavakoli, John D Short, Kevin Downs, Huynh Nga Nguyen, Yanlai Lai, Wei Zhang, Paul Jerabek, Beth Goins, Mehran M Sadeghi, Reto Asmis
Purpose To determine the divergence of immunometabolic phenotypes of macrophages stimulated with macrophage colony-stimulating factor (M-CSF) and granulocyte-M-CSF (GM-CSF) and its implications for fluorine 18 ((18)F) fluorodeoxyglucose (FDG) imaging of atherosclerosis. Materials and Methods This study was approved by the animal care committee. Uptake of 2-deoxyglucose and various indexes of oxidative and glycolytic metabolism were evaluated in nonactivated murine peritoneal macrophages (MΦ0) and macrophages stimulated with M-CSF (MΦM-CSF) or GM-CSF (MΦGM-CSF)...
November 16, 2016: Radiology
https://www.readbyqxmd.com/read/27846378/tumor-delineation-and-quantitative-assessment-of-glucose-metabolic-rate-within-histologic-subtypes-of-non-small-cell-lung-cancer-by-using-dynamic-18-f-fluorodeoxyglucose-pet
#17
Tineke W H Meijer, Lioe-Fee de Geus-Oei, Eric P Visser, Wim J G Oyen, Monika G Looijen-Salamon, Dimitris Visvikis, Ad F T M Verhagen, Johan Bussink, Dennis Vriens
Purpose To assess whether dynamic fluorine 18 ((18)F) fluorodeoxyglucose (FDG) positron emission tomography (PET) has added value over static (18)F-FDG PET for tumor delineation in non-small cell lung cancer (NSCLC) radiation therapy planning by using pathology volumes as the reference standard and to compare pharmacokinetic rate constants of (18)F-FDG metabolism, including regional variation, between NSCLC histologic subtypes. Materials and Methods The study was approved by the institutional review board. Patients gave written informed consent...
November 15, 2016: Radiology
https://www.readbyqxmd.com/read/27846377/tumefactive-gallbladder-sludge-at-us-prevalence-and-clinical-importance
#18
Mimi Kim, Tae Wook Kang, Kyung Mi Jang, Young Kon Kim, Seong Hyun Kim, Sang Yun Ha, Dong Hyun Sinn, Seonhye Gu
Purpose To evaluate the prevalence of tumefactive sludge of the gallbladder detected at ultrasonography (US) and to assess whether any clinical and imaging differences exist between benign and malignant tumefactive sludge. Materials and Methods The institutional review board approved this retrospective study. The requirement for informed consent was waived. The study included a cohort (n = 6898) of patients with gallbladder sludge drawn from all adults (n = 115 178) who underwent abdominal US between March 2001 and March 2015...
November 15, 2016: Radiology
https://www.readbyqxmd.com/read/27841728/pet-of-poly-adp-ribose-polymerase-activity-in-cancer-preclinical-assessment-and-first-in-human-studies
#19
Loren S Michel, Samantha Dyroff, Frank J Brooks, Katherine J Spayd, Sora Lim, Jacquelyn T Engle, Sharon Phillips, Benjamin Tan, Andrea Wang-Gillam, Christopher Bognar, Wenhua Chu, Dong Zhou, Robert H Mach, Richard Laforest, Delphine L Chen
Purpose To demonstrate that positron emission tomography (PET) with fluorine 18 ((18)F) fluorthanatrace (FTT) depicts activated poly (adenosine diphosphate-ribose)polymerase (PARP) expression and is feasible for clinical trial evaluation. Materials and Methods All studies were conducted prospectively from February 2012 through July 2015 under protocols approved by the local animal studies committee and institutional review board. The area under the receiver operating characteristic curve (AUC, in g/mL· min) for (18)F-FTT was assessed in normal mouse organs before and after treatment with olaparib (n = 14), a PARP inhibitor, or iniparib (n = 11), which has no PARP inhibitory activity...
November 14, 2016: Radiology
https://www.readbyqxmd.com/read/27831831/common-data-elements-in-radiology
#20
Daniel L Rubin, Charles E Kahn
Diagnostic radiologists generally produce unstructured information in the form of images and narrative text reports. Although designed for human consumption, radiologic reports contain a wealth of information that could be valuable for clinical care, research, and quality improvement if that information could be extracted by automated systems. Unfortunately, the lack of structure in radiologic reports limits the ability of information systems to share information easily with other systems. A common data element (CDE)-a unit of information used in a shared, predefined fashion-can improve the ability to exchange information seamlessly among information systems...
November 10, 2016: Radiology
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