journal
https://read.qxmd.com/read/38328967/estimating-disparities-of-prostate-cancer-burden-and-its-attributable-risk-factors-for-males-across-the-brics-plus-1990-2019-a-comparable-study-of-key-nations-with-emerging-economies
#21
JOURNAL ARTICLE
Li-Sha Luo, Jiao Huang, Hang-Hang Luan, Sumaira Mubarik, Quliang Zhong, Xian-Tao Zeng
BACKGROUNDS: The study aimed to analyze epidemiology burden of male prostate cancer across the BRICS-plus, and identify potential risk factors by assessing the associations with age, period, birth cohorts and sociodemographic index (SDI). METHODS: Data were extracted from the Global Burden of Disease Study 2019. The average annual percent change (AAPC) was calculated to assess long-term trends, and age-period-cohort analysis was used to analyze these three effects on prostate cancer burden...
February 8, 2024: Prostate
https://read.qxmd.com/read/38311868/efficacy-tolerability-and-safety-of-teverelix-dp-in-patients-with-advanced-prostate-cancer-a-multicenter-open-label-phase-2-trial
#22
JOURNAL ARTICLE
Albertas Ulys, Feliksas Jankevicus, Mindaugas Jievaltas, Raimundas Venckus, Stasys Auskalnis, Zygimantas Kardelis, Marija Barisiene, Carol M MacLean, Steve van Os, Finn Larsen
BACKGROUND: Teverelix drug product (DP) is a novel injectable gonadotropin-releasing hormone antagonist. METHODS: An adaptive phase 2, open-label, multicenter trial was conducted in patients with advanced prostate cancer to evaluate the efficacy and safety of a combined subcutaneous (SC) and intramuscular (IM) loading dose regimen of teverelix DP of 120 mg SC + 120 mg IM (Group 1; N = 9) or 180 mg SC + 180 mg IM (Group 2; N = 41) administered at a single visit, followed by 6-weekly SC maintenance doses of 120 mg (Group 1) or 180 mg (Group 2), up to Day 168...
February 4, 2024: Prostate
https://read.qxmd.com/read/38311854/impact-of-presentation-timing-in-metastatic-hormone-sensitive-prostate-cancer-characterization-of-patients-and-identification-of-prognostic-factors
#23
JOURNAL ARTICLE
Juliana Arenas Hoyos, David Ruiz Londoño, Andres Gomez Hoyos, Estefania Celis Reyes, Rodolfo Varela, Julian Serrano Giraldo
BACKGROUND: The treatment and surveillance of metastatic hormone-sensitive prostate cancer (mHSPC) has evolved since the introduction of several treatment intensification options associated with hormonal blockade and classifications based on the timing of metastatic disease presentation and disease volume. Using a hospital-based registry, we aimed to assess whether these new classifications are applicable to our population, as few studies have demonstrated their prognostic value for overall survival (OS) and time to development of castration-resistant prostate cancer (CRPC), and to establish prognostic factors in our population...
February 4, 2024: Prostate
https://read.qxmd.com/read/38212952/metabolic-analysis-using-hr-mas-in-prostate-tissue-for-prostate-cancer-diagnosis
#24
JOURNAL ARTICLE
Jorge Panach-Navarrete, Vannina González-Marrachelli, José Manuel Morales-Tatay, Francisco García-Morata, María Ángeles Sales-Maicas, Daniel Monleón-Salvado, José María Martínez-Jabaloyas
INTRODUCTION: In this study we used nuclear magnetic resonance spectroscopy in prostate tissue to provide new data on potential biomarkers of prostate cancer in patients eligible for prostate biopsy. MATERIAL AND METHODS: Core needle prostate tissue samples were obtained. After acquiring all the spectra using a Bruker Avance III DRX 600 spectrometer, tissue samples were subjected to routine histology to confirm presence or absence of prostate cancer. Univariate and multivariate analyses with metabolic and clinical variables were performed to predict the occurrence of prostate cancer...
January 11, 2024: Prostate
https://read.qxmd.com/read/38193363/link-between-circadian-rhythm-and-benign-prostatic-hyperplasia-bph-lower-urinary-tract-symptoms-luts
#25
REVIEW
Dana Cavanaugh, Alfonso Urbanucci, Nihal E Mohamed, Ashutosh K Tewari, Mariana Figueiro, Natasha Kyprianou
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health-related quality of life implores further investigation into its risk factors and strategies for effective management. Although the exact molecular mechanisms underlying pathophysiological onset of BPH are poorly defined, the current hypothesized contributors to BPH and lower urinary tract symptoms (LUTS) include aging, inflammation, metabolic syndrome, and hormonal changes...
January 9, 2024: Prostate
https://read.qxmd.com/read/38192023/whole-exome-sequencing-of-nigerian-benign-prostatic-hyperplasia-reveals-increased-alterations-in-apoptotic-pathways
#26
JOURNAL ARTICLE
Jason A White, Ernest T Kaninjing, Kayode A Adeniji, Paul Jibrin, John O Obafunwa, Chidiebere N Ogo, Faruk Mohammed, Ademola Popoola, Omolara A Fatiregun, Olabode P Oluwole, Roland J Thorpe, Balasubramanyam Karanam, Isra Elhussin, Stefan Ambs, Wei Tang, Melissa Davis, Paz Polak, Moray J Campbell, Kathryn R Brignole, Solomon O Rotimi, Windy Dean-Colomb, Folake T Odedina, Clayton Yates
BACKGROUND: Through whole-exome sequencing of 60 formalin-fixed paraffin-embedded Nigerian (NGRn) benign prostatic hyperplasia (BPH) samples, we identified germline and somatic alterations in apoptotic pathways impacting BPH development and progression. Prostate enlargement is a common occurrence in male aging; however, this enlargement can lead to lower urinary tract symptoms that negatively impact quality of life. This impact is disproportionately present in men of African ancestry...
January 8, 2024: Prostate
https://read.qxmd.com/read/38173302/diagnosis-and-management-of-neuroendocrine-prostate-cancer
#27
REVIEW
Ivan de Kouchkovsky, Emily Chan, Charles Schloss, Christian Poehlein, Rahul Aggarwal
BACKGROUND: Although most patients with prostate cancer (PC) respond to initial androgen deprivation therapy (ADT), castration-resistant disease invariably develops. Progression to treatment-emergent neuroendocrine PC (t-NEPC) represents a unique mechanism of resistance to androgen receptor (AR)-targeted therapy in which lineage plasticity and neuroendocrine differentiation induce a phenotypic switch from an AR-driven adenocarcinoma to an AR-independent NEPC. t-NEPC is characterized by an aggressive clinical course, increased resistance to AR-targeted therapies, and a poor overall prognosis...
January 3, 2024: Prostate
https://read.qxmd.com/read/38173301/utilization-trend-of-prebiopsy-multiparametric-magnetic-resonance-imaging-and-its-impact-on-prostate-cancer-detection-real-world-insights-from-a-high-volume-center-in-southwest-china
#28
JOURNAL ARTICLE
Chichen Zhang, Xiang Tu, Jindong Dai, Zilong Zhang, Chenlan Shen, Qiyou Wu, Zhenhua Liu, Tianhai Lin, Shi Qiu, Lu Yang, Ling Yang, Mengni Zhang, Diming Cai, Yige Bao, Hao Zeng, Qiang Wei
BACKGROUND: Data on the utilization and effects of prebiopsy prostate multiparametric magnetic resonance imaging (mpMRI) to support its routine use in real-world setting are still scarce. OBJECTIVE: To evaluate the change of clinical practice of prebiopsy mpMRI over time, and assess its diagnostic accuracy. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed data from 6168 patients who underwent primary prostate biopsy (PBx) between January 2011 and December 2021 and had prostate-specific antigen (PSA) values ranging from 3 to 100 ng/mL...
January 3, 2024: Prostate
https://read.qxmd.com/read/38173289/fewer-systematic-prostate-core-biopsies-in-clinical-stage-t1c-prostate-cancer-leads-to-biochemical-recurrence-after-brachytherapy-as-monotherapy
#29
JOURNAL ARTICLE
Yu Ozawa, Sunao Nohara, Ken Nakamura, Seiya Hattori, Yasuto Yagi, Toru Nishiyama, Atsunori Yorozu, Tetsuo Monma, Shiro Saito
BACKGROUND: After brachytherapy, fewer prostate biopsy cores at diagnosis can underestimate the pathological characteristics of prostate cancer (PCa) with lower concordance, resulting in improper treatment, particularly in patients with low-risk nonpalpable cT1c PCa. The aim of this study was to assess the relationship between the number of biopsy cores at diagnosis and long-term clinical outcomes after brachytherapy for cT1c PCa. METHODS: We reviewed 516 patients with localized cT1c PCa with Gleason scores of 3 + 3 = 6 or 3 + 4 = 7 who underwent brachytherapy as monotherapy without hormonal therapy between January 2005 and September 2014 at our institution...
January 3, 2024: Prostate
https://read.qxmd.com/read/38173273/distribution-of-neurovascular-structures-within-the-prostate-gland-and-their-relationship-to-complications-after-radical-prostatectomy
#30
JOURNAL ARTICLE
Ghazi Alanazi, Najah Alsubaie, Ghulam Nabi, Thomas H Gillingwater, Abduelmenem Alashkham
BACKGROUND: Radical prostatectomy remains the main choice of treatment for prostate cancer. However, despite improvements in surgical techniques and neurovascular sparing procedures, rates of erectile dysfunction, and urinary incontinence remain variable. This is due, at least in part, to an incomplete understanding of neurovascular structures associated with the prostate. The objective of this study was to provide a comprehensive, detailed histological overview of the distribution of nerves and blood vessels within the prostate, facilitating subsequent correlation of prostatic neurovascular structures with patients' clinical outcomes after radical prostatectomy...
January 3, 2024: Prostate
https://read.qxmd.com/read/38168866/transcriptomic-analysis-of-benign-prostatic-hyperplasia-identifies-critical-pathways-in-prostatic-overgrowth-and-5-alpha-reductase-inhibitor-resistance
#31
JOURNAL ARTICLE
Renjie Jin, Connor M Forbes, Nicole L Miller, John Lafin, Douglas W Strand, Thomas Case, Justin M Cates, Qi Liu, Marisol Ramirez-Solano, James L Mohler, Robert J Matusik
BACKGROUND: The medical therapy of prostatic symptoms (MTOPS) trial randomized men with symptoms of benign prostatic hyperplasia (BPH) and followed response of treatment with a 5α-reductase inhibitor (5ARI), an alpha-adrenergic receptor antagonist (α-blocker), the combination of 5ARI and α-blocker or no medical therapy (none). Medical therapy reduced risk of clinical progression by 66% but the reasons for nonresponse or loss of therapeutic response in some patients remains unresolved...
January 3, 2024: Prostate
https://read.qxmd.com/read/38116741/based-on-pi-rads-v2-1-combining-phi-and-adc-values-to-guide-prostate-biopsy-in-patients-with-psa-4-20%C3%A2-ng-ml
#32
JOURNAL ARTICLE
Hua Huang, Zihao Liu, Yuan Ma, Yuan Shao, Zhen Yang, Dengyi Duan, Yang Zhao, Simeng Wen, Jing Tian, Yang Liu, Zeyuan Wang, Dan Yue, Yong Wang
PURPOSE: The study aimed to investigate the diagnostic accuracy of prostate health index (PHI) and apparent diffusion coefficient (ADC) values in predicting prostate cancer (PCa) and construct a nomogram for the prediction of PCa and clinically significant PCa (CSPCa) in Prostate Imaging-Reporting and Data System (PI-RADS) three lesions cohort. METHODS: This study prospectively enrolled 301 patients who underwent multiparametric magnetic resonance (mpMRI) and were scheduled for prostate biopsy...
March 2024: Prostate
https://read.qxmd.com/read/38041475/adjuvant-and-salvage-radiotherapy-after-neoadjuvant-therapy-and-radical-prostatectomy-for-high-risk-localized-prostate-cancer
#33
JOURNAL ARTICLE
Praful Ravi, Lucia Kwak, Wout Devlies, Wanling Xie, Fallon Chipidza, Xiaoyu Yang, Glenn Bubley, Irving Kaplan, Adam S Kibel, Paul Nguyen, Mary-Ellen Taplin
BACKGROUND: We sought to describe patterns of delivery of adjuvant (aRT) and salvage RT (sRT) in patients who underwent RP after receiving neoadjuvant androgen receptor pathway inhibitor (ARPI) before radical prostatectomy (RP) for high-risk localized prostate cancer (HRLPC). METHODS: Two hundred eighteen patients treated on phase 2 neoadjuvant trials between 2006 and 2018 at two academic centers were evaluated. aRT and sRT were defined as receipt of RT with a PSA of ≤0...
March 2024: Prostate
https://read.qxmd.com/read/37899678/the-association-between-several-serum-micronutrients-and-benign-prostatic-hyperplasia-results-from-nhanes-2003-2006
#34
JOURNAL ARTICLE
Hang Zhou, Mingming Xu, Yang Pan, Shangren Wang, Zhunan Xu, Li Liu, Xiaoqiang Liu
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common condition that affects the quality of life of older men. Specific micronutrients, including retinol, retinyl esters, carotenoids, vitamin E, and vitamin C, have antioxidant and anti-inflammatory properties. However, the correlation between serum concentrations of these micronutrients and BPH is unclear. METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES), which included 2067 representative US men...
February 2024: Prostate
https://read.qxmd.com/read/37888416/biological-role-of-fructose-in-the-male-reproductive-system-potential-implications-for-prostate-cancer
#35
REVIEW
Carolina E Echeverría, Vanessa I Oyarzún, Andrés López-Cortés, Jorge Cancino, Paula C Sotomayor, Marcus D Goncalves, Alejandro S Godoy
BACKGROUND: Over the last 20 years, fructose has gradually emerged as a potential metabolic substrate capable of promoting the growth and progression of various cancers, including prostate cancer (PCa). The biological and molecular mechanisms that underlie the effects of fructose on cancer are beginning to be elucidated. METHODS: This review summarizes the biological function of fructose as a potential carbon source for PCa cells and its role in the functionality of the male reproductive tract under normal conditions...
January 2024: Prostate
https://read.qxmd.com/read/37828815/microultrasound-in-the-detection-of-the-index-lesion-in-prostate-cancer
#36
JOURNAL ARTICLE
Adriana M Pedraza, Raghav Gupta, David Musheyev, Tanisha Pino, Akash Shah, Rachel Brody, Vinayak Wagaskar, Basil Kaufmann, Michael A Gorin, Mani Menon, Ashutosh Tewari
INTRODUCTION AND OBJECTIVE: The natural progression of prostate cancer is primarily driven by an index lesion (IL). Studies have shown that different metastases within the same patient arise from a single precursor cell. Therefore, our aim is to assess the effectiveness of transrectal microultrasound (MUS) in comparison to multiparametric magnetic resonance imaging (mpMRI) for detecting the IL in prostate cancer. We used quarter-mount pathological results as the reference standard for this evaluation...
January 2024: Prostate
https://read.qxmd.com/read/37750292/the-diagnostic-accuracy-of-68-ga-psma-pet-ct-in-primary-staging-of-patients-with-high-risk-nonmetastatic-prostate-cancer-treated-with-radical-prostatectomy-a-single-center-cohort-analysis
#37
JOURNAL ARTICLE
Pawel Rajwa, Julian Heidenreich, Alexander Drzezga, Matthias Schmidt, Shahrokh F Shariat, Axel Heidenreich
BACKGROUND: 68 Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is a recommended imaging modality for patients with recurrent prostate cancer (PCa). Its routine implementation before radical prostatectomy (RP) may allow avoiding undertreatment. We aimed to analyze the diagnostic accuracy of 68 Ga-PSMA-PET/CT for pelvic lymph node metastases in a large cohort of patients treated with RP and extended pelvic lymph node dissection (ePLND) for high-risk PCa...
January 2024: Prostate
https://read.qxmd.com/read/37710384/the-association-between%C3%A2-beta-blockers-use-and-prostate-cancer-mortality-a-mini-systematic-review-and-meta-analysis
#38
REVIEW
Alessandro Uleri, Michael Baboudjian, Alessandro Tedde, Pawel Rajwa, Benjamin Pradere, Andrea Gallioli, Alberto Breda, Guillaume Ploussard
BACKGROUND: Preclinical studies have shown that the sympathetic nervous system is involved in the development of metastases, suggesting a potential antitumor effect of beta-blockers. These findings sparked a controversy over the past decade regarding the direction of the association between beta-blocker use and prostate cancer (PCa) mortality. To investigate this association, we conducted a systematic review and meta-analysis. METHODS: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to identify eligible studies...
January 2024: Prostate
https://read.qxmd.com/read/37661579/the-role-of-psma-pet-ct-to-predict-upgrading-in-patients-undergoing-radical-prostatectomy-for-isup-grade-group-1-prostate-cancer
#39
JOURNAL ARTICLE
Baris Esen, Hulya Seymen, Bengi Gurses, Ayse Armutlu, Ersin Koseoglu, Kayhan Tarim, Dilek Ertoy Baydar, Ahmet Furkan Sarikaya, Abdullah Erdem Canda, Derya Balbay, Yakup Kordan, Derya Tilki, Tarik Esen, Mehmet Onur Demirkol
INTRODUCTION AND OBJECTIVES: To investigate the additive role of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) independent from multiparametric magnetic resonance imaging (mpMRI) and clinical-pathological parameters to predict pathological upgrading in patients with ISUP grade group (GG) 1 prostate cancer (PCa) at prostate biopsy. MATERIALS AND METHODS: A total of 41 patients who underwent robotic radical prostatectomy (RP) for GG1 disease at prostate biopsy with preoperative PSMA PET/CT and mpMRI images available for central review were included in the study...
January 2024: Prostate
https://read.qxmd.com/read/38151791/prostate-specific-membrane-antigen-psma-glycoforms-in-prostate-cancer-patients-seminal-plasma
#40
JOURNAL ARTICLE
Stephen Mackay, Ian O Oduor, Tanya C Burch, Dean A Troyer, Oliver J Semmes, Julius O Nyalwidhe
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is a US Food and Drug Administration-approved theranostic target for prostate cancer (PCa). Although PSMA is known to be glycosylated, the composition and functional roles of its N-linked glycoforms have not been fully characterized. METHODS: PSMA was isolated from pooled seminal plasma from low-risk grade Groups 1 and 2 PCa patients. Intact glycopeptides were analyzed by mass spectrometry to identify site-specific glycoforms...
December 27, 2023: Prostate
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