journal
https://read.qxmd.com/read/38544351/quantification-and-molecular-correlates-of-tertiary-lymphoid-structures-in-primary-prostate-cancer
#1
JOURNAL ARTICLE
Mohammed Shahait, Alexander K Hakansson, Reba E Daniel, Kareem Hosny, Elai Davicioni, Seagle Yang Liu, Alex Sandberg, David I Lee, Priti Lal
OBJECTIVE: To morphologically describe tertiary lymphoid structures (TLS) in prostatectomy specimens and correlate them with clinical and transcriptomic features. METHODOLOGY: A total of 72 consecutive cases of entirely submitted radical prostatectomy (RP) patients tested with the Decipher Genomic Classifier were included in the study. Images were manually annotated using QuPath tools to denote tumor regions and each cluster of TLS. Clusters of lymphocytes that were surrounded on all four sides by tumor were defined as intra-tumor TLS (IT-TLS)...
March 27, 2024: Prostate
https://read.qxmd.com/read/38544345/clinical-validation-of-circulating-gdf15-mic-1-as-a-marker-of-response-to-docetaxel-and-survival-in-men-with-metastatic-castration-resistant-prostate-cancer
#2
JOURNAL ARTICLE
Kate L Mahon, Sarah Im Sutherland, Hui Ming Lin, Martin R Stockler, Howard Gurney, Girish Mallesara, Karen Briscoe, Gavin Marx, Celestia S Higano, Johann S de Bono, Kim N Chi, Georgina Clark, Samuel N Breit, David A Brown, Lisa G Horvath
BACKGROUND: Elevated circulating growth differentiation factor (GDF15/MIC-1), interleukin 4 (IL4), and IL6 levels were associated with resistance to docetaxel in an exploratory cohort of men with metastatic castration-resistant prostate cancer (mCRPC). This study aimed to establish level 2 evidence of cytokine biomarker utility in mCRPC. METHODS: IntVal: Plasma samples at baseline (BL) and Day 21 docetaxel (n = 120). ExtVal: Serum samples at BL and Day 42 of docetaxel (n = 430)...
March 27, 2024: Prostate
https://read.qxmd.com/read/38528654/cd44-and-cd133-protein-expression-might-serve-as-a-prognostic-factor-for-early-occurrence-castration-resistant-prostate-cancer
#3
JOURNAL ARTICLE
Yayi Dwina, Litta Septina Mahmelia Zaid, Meilania Saraswati, Lisnawati Rachmadi, Aria Kekalih, Nur Rahadiani, Melva Louisa, Hasrayati Agustina, Chaidir Arif Mochtar, Agus Rizal Ardy Hariandy Hamid
BACKGROUND: The occurrence of castration-resistant prostate cancer (CRPC) varies in patients with advanced prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). The rate of occurrence of CRPC may be related to the presence of prostate cancer stem cells (CSC). Thus, this study aims to evaluate the presence of CSC markers (CD44 and CD133) in histopathology tissue at the time of diagnosis and their correlation with the occurrence of CRPC in patients with advanced PCa within 2 years of ADT...
March 25, 2024: Prostate
https://read.qxmd.com/read/38528236/the-effect-of-dose-escalation-radiotherapy-with-simultaneous-integrated-boost-on-the-use-of-short-term-androgen-deprivation-therapy-in-patients-with-intermediate-risk-prostate-cancer
#4
JOURNAL ARTICLE
Cem Onal, Ozan Cem Guler, Gurcan Erbay, Aysenur Elmali
PURPOSE: To compare the biochemical failure (FFBF) and prostate cancer specific survival (PCSS) rates of patients with intermediate-risk prostate cancer (IR-PC) who were treated with 6 months of androgen deprivation therapy (ADT) with 78 Gy to the prostate, those treated with ADT and focal boost (FB) of 86 Gy to intraprostatic lesion (IPL) using the simultaneous-integrated boost (SIB) technique, and those treated with SIB alone. MATERIALS AND METHODS: A retrospective analysis of 320 IR-PC patients treated between January 2012 and April 2021 was performed...
March 25, 2024: Prostate
https://read.qxmd.com/read/38506561/other-cause-mortality-in-incidental-prostate-cancer
#5
JOURNAL ARTICLE
Francesco Di Bello, Andrea Baudo, Mario de Angelis, Letizia Maria Ippolita Jannello, Carolin Siech, Zhe Tian, Jordan A Goyal, Claudia Collà Ruvolo, Gianluigi Califano, Roberto La Rocca, Simone Morra, Pietro Acquati, Fred Saad, Shahrokh F Shariat, Luca Carmignani, Ottavio de Cobelli, Alberto Briganti, Felix K H Chun, Nicola Longo, Pierre I Karakiewicz
BACKGROUND: In incidental prostate cancer (IPCa), elevated other-cause mortality (OCM) may obviate the need for active treatment. We tested OCM rates in IPCa according to treatment type and cancer grade and we hypothesized that OCM is significantly higher in not-actively-treated patients. METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2015), IPCa patients were identified. Smoothed cumulative incidence plots as well as multivariable competing risks regression models were fitted to address OCM after adjustment for cancer-specific mortality (CSM)...
March 20, 2024: Prostate
https://read.qxmd.com/read/38504659/key-learnings-from-concordant-systematic-biopsies-in-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-guided-prostate-biopsies-enhancing-targeting-accuracy
#6
JOURNAL ARTICLE
Thomas Büttner, Florian Gärtner, Markus Essler, Richard Weiten, Glen Kristiansen, Jörg Ellinger, Manuel Ritter, Philipp Krausewitz
BACKGROUND: Prostate cancer (PCa) diagnosis and staging have evolved with the advent of 68Ga-Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT). This study investigates the role of complementary systematic biopsies (SB) during PSMA-PET/CT-guided targeted prostate biopsies (PET-TB) for PCa detection, grading, and distribution. We address the uncertainty surrounding the necessity of SB in conjunction with PET-TB. METHODS: We analyzed PCa grading and distribution in 30 men who underwent PET-TB and SB because of contraindication to magnetic resonance imaging or high clinical suspicion of PCa...
March 20, 2024: Prostate
https://read.qxmd.com/read/38497426/voc-based-detection-of-prostate-cancer-using-an-electronic-nose-and-ion-mobility-spectrometry-a-novel-urine-based-approach
#7
JOURNAL ARTICLE
Hendrik Heers, Oliver Chwilka, Johannes Huber, Claus Vogelmeier, Andreas Rembert Koczulla, Jörg Ingo Baumbach, Tobias Boeselt
BACKGROUND: Many diseases leave behind specific metabolites which can be detected from breath and urine as volatile organic compounds (VOC). Our group previously described VOC-based methods for the detection of bladder cancer and urinary tract infections. This study investigated whether prostate cancer can be diagnosed from VOCs in urine headspace. METHODS: For this pilot study, mid-stream urine samples were collected from 56 patients with histologically confirmed prostate cancer...
March 18, 2024: Prostate
https://read.qxmd.com/read/38477025/multispecies-comparative-prostate-anatomy-by-imaging-implications-for-experimental-models-of-prostatic-disease
#8
JOURNAL ARTICLE
Felipe M Berg, Eduardo T O Correia, Eric C Abenojar, James P Basilion, Thomas J Rosol, Ronaldo H Baroni, Agata A Exner, Leonardo K Bittencourt
BACKGROUND: There is an increasing interest in using preclinical models for development and assessment of medical devices and imaging techniques for prostatic disease care. Still, a comprehensive assessment of the prostate's radiological anatomy in primary preclinical models such as dogs, rabbits, and mice utilizing human anatomy as a reference point remains necessary with no optimal model for each purpose being clearly defined in the literature. Therefore, this study compares the anatomical characteristics of different animal models to the human prostatic gland from the imaging perspective...
March 13, 2024: Prostate
https://read.qxmd.com/read/38477020/a-west-african-ancestry-associated-snp-on-8q24-predicts-a-positive-biopsy-in-african-american-men-with-suspected-prostate-cancer-following-psa-screening
#9
JOURNAL ARTICLE
Jian Gu, Lisly Chery, Graciela M Nogueras González, Chad Huff, Sara Strom, Jeffrey A Jones, Donald P Griffith, Steven E Canfield, Xuemei Wang, Xuelin Huang, Pamela Roberson, Qing H Meng, Patricia Troncoso, Michael Ittmann, Michael Covinsky, Michael Scheurer, Margarita Irizarry Ramirez, Curtis A Pettaway
BACKGROUND: African American (AA) men have the highest incidence and mortality rates of prostate cancer (PCa) among all racial groups in the United States. While race is a social construct, for AA men, this overlaps with west African ancestry. Many of the PCa susceptibility variants exhibit distinct allele frequencies and risk estimates across different races and contribute substantially to the large disparities of PCa incidence among races. We previously reported that a single-nucleotide polymorphism (SNP) in 8q24, rs7824364, was strongly associated with west African ancestry and increased risks of PCa in both AA and Puerto Rican men...
March 13, 2024: Prostate
https://read.qxmd.com/read/38476030/cumulative-cancer-locations-on-prostate-biopsy-and-active-surveillance-outcomes-in-the-mri-era
#10
JOURNAL ARTICLE
Sean A Fletcher, Mufaddal M Mamawala, Albert E Holler, Yasin Bhanji, Katarzyna J Macura, Claire M de la Calle, Christian P Pavlovich
BACKGROUND: To validate the use of a cumulative cancer locations (CCLO) score, a measurement of tumor volume on biopsy, and to develop a novel magnetic resonance imaging (MRI)-informed CCLO (mCCLO) score to predict clinical outcomes on active surveillance (AS). METHODS: The CCLO score is a sum of uniquely involved sextants with prostate cancer on diagnostic + confirmatory biopsy. The mCCLO score incorporates MRI findings into the CCLO score. Participants included 1284 individuals enrolled on AS between 1994 and 2022, 343 of whom underwent prostate MRI...
March 13, 2024: Prostate
https://read.qxmd.com/read/38450798/defining-the-challenges-and-opportunities-for-using-patient-derived-models-in-prostate-cancer-research
#11
REVIEW
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
BACKGROUND: There are relatively few widely used models of prostate cancer compared to other common malignancies. This impedes translational prostate cancer research because the range of models does not reflect the diversity of disease seen in clinical practice. In response to this challenge, research laboratories around the world have been developing new patient-derived models of prostate cancer, including xenografts, organoids, and tumor explants. METHODS: In May 2023, we held a workshop at the Monash University Prato Campus for researchers with expertise in establishing and using a variety of patient-derived models of prostate cancer...
March 7, 2024: Prostate
https://read.qxmd.com/read/38450787/implementation-of-psma-pet-ct-and-alignment-of-ordering-to-snmmi-appropriate-use-criteria-in-a-large-network-system
#12
JOURNAL ARTICLE
Richard Bennett, Eric V Li, Austin Y Ho, Jonathan A Aguiar, Clayton Neill, Steven P Rowe, Hiten D Patel, Hatice Savas, Ashley E Ross
INTRODUCTION: The Society of Nuclear Medicine and Molecular Imaging (SNMMI) provides appropriate use criteria (AUC) for prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) which include guidance on imaging in newly diagnosed prostate cancer and in patients with biochemically recurrent (BCR) disease. This study aims to examine trends in PSMA implementation and the prevalence and outcomes of scans ordered in scenarios deemed rarely appropriate or not meeting SNMMI AUC...
March 7, 2024: Prostate
https://read.qxmd.com/read/38444115/sodium-butyrate-alleviates-experimental-autoimmune-prostatitis-by-inhibiting-oxidative-stress-and-nlrp3-inflammasome-activation-via-the-nrf2-ho-1-pathway
#13
JOURNAL ARTICLE
Xiaoliang Hua, Jiong Zhang, Juan Chen, Rui Feng, Li Zhang, Xianguo Chen, Qing Jiang, Cheng Yang, Chaozhao Liang
BACKGROUND: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) leads to severe discomfort in males and loss of sperm quality. Current therapeutic options have failed to achieve satisfactory results. Sodium butyrate (NaB) plays a beneficial role in reducing inflammation, increasing antioxidant capacities, and improving organ dysfunction; additionally NaB has good safety prospects and great potential for clinical application. The purpose of the current research was to study the effect of NaB on CP/CPPS and the underlying mechanisms using a mouse model of experimental autoimmune prostatitis (EAP) mice...
March 5, 2024: Prostate
https://read.qxmd.com/read/38414098/preanalytical-stability-of-molecular-forms-of-prostate-specific-antigen-in-serum-samples-psa-free-psa-2-propsa-and-their-impact-on-fpsa-tpsa-ratio-and-phi
#14
JOURNAL ARTICLE
Václav Šimánek, Radana Vrzáková, Roman Viták, Michal Jirásko, Tomáš Fürst, Ondřej Topolčan, Ladislav Pecen, Vladimír Vurm, Radek Kučera
BACKGROUND: Prostate cancer is a common cancer in men. Detection methods include the measurement of biomarkers: prostate-specific antigen (PSA), free PSA, [-2]proPSA, and the calculated indices: fPSA/tPSA ratio and Prostate Health Index (PHI). Proper preanalytical conditions are crucial for precise measurement and failure to adhere to protocols or regulations can influence the diagnostic algorithm. We assessed the stability of the above-mentioned biomarkers, fPSA/tPSA ratio and PHI, under various pre-analytical conditions...
February 27, 2024: Prostate
https://read.qxmd.com/read/38413843/testosterone-bounce-predicts-favorable-prognoses-for-prostate-cancer-patients-treated-with-degarelix
#15
JOURNAL ARTICLE
Shuhei Kamada, Shinichi Sakamoto, Ryo Kinoshita, Xue Zhao, Tomohiko Kamasako, Ryosuke Yamase, Rii Junryo, Shinpei Saito, Pae Sangjon, Akinori Takei, Yasutaka Yamada, Yusuke Goto, Yusuke Imamura, Taro Iguchi, Atsushi Mizokami, Hiroyoshi Suzuki, Koichiro Akakura, Tomohiko Ichikawa
BACKGROUND: To clarify the clinical roles of changes in testosterone (T) levels with a cut-off level of 20 ng/dL as predictive factors for prostate cancer patients treated with degarelix acetate. METHODS: A total of 120 prostate cancer patients who received hormone therapies with gonadotropin-releasing hormone antagonist degarelix acetate were retrospectively analyzed. The predictive values of nadir T levels, max T levels, T bounce, and other clinical factors were evaluated for overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS)...
February 27, 2024: Prostate
https://read.qxmd.com/read/38409853/cancer-cells-employ-lipid-droplets-to-survive-toxic-stress
#16
JOURNAL ARTICLE
Laurie G Kostecka, Sabrina Mendez, Melvin Li, Pratik Khare, Cissy Zhang, Anne Le, Sarah R Amend, Kenneth J Pienta
BACKGROUND: Lipid reprogramming is a known mechanism to increase the energetic demands of proliferating cancer cells to drive and support tumorigenesis and progression. Elevated lipid droplets (LDs) are a well-known alteration of lipid reprogramming in many cancers, including prostate cancer (PCa), and are associated with high tumor aggressiveness as well as therapy resistance. The mechanism of LD accumulation and specific LD functions are still not well understood; however, it has been shown that LDs can form as a protective mechanism against lipotoxicity and lipid peroxidation in the cell...
February 26, 2024: Prostate
https://read.qxmd.com/read/38375594/a-novel-hdac6-inhibitor-interferes-microtubule-dynamics-and-spindle-assembly-checkpoint-and-sensitizes-cisplatin-induced-apoptosis-in-castration-resistant-prostate-cancer
#17
JOURNAL ARTICLE
Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Zi-Yuan Wei, Yi-Chin Chen, Yi-Chang Chiang, Jui-Ling Hsu, She-Hung Chan, Lih-Ching Hsu, Ji-Wang Chern, Chao-Wu Yu, Jih-Hwa Guh
BACKGROUND: Metastatic castration-resistant prostate cancer (CRPC), the most refractory prostate cancer, inevitably progresses and becomes unresponsive to hormone therapy, revealing a pressing unmet need for this disease. Novel agents targeting HDAC6 and microtubule dynamics can be a potential anti-CRPC strategy. METHODS: Cell proliferation was examined in CRPC PC-3 and DU-145 cells using sulforhodamine B assay and anchorage-dependent colony formation assay. Flow cytometric analysis of propidium iodide staining was used to determine cell-cycle progression...
February 20, 2024: Prostate
https://read.qxmd.com/read/38372065/development-of-depression-in-patients-using-androgen-deprivation-therapy-a-systemic-review-and-meta-analysis
#18
REVIEW
Shurjeel Uddin Qazi, Zahabia Altaf, Mariam Zafar, Muhammad Ali Tariq, Areesha Khalid, Aleesha Kaleem, Emaan Saad, Sana Qazi
BACKGROUND: Androgen deprivation therapy (ADT) is an effective treatment for advanced prostate cancer (PCa). Multiple studies have highlighted serious consequences this therapy poses to mental health, particularly depression. We aimed to review the incidence and association between ADT in men with PCa and the risk of depression. METHODS: We systematically searched multiple databases, including MEDLINE, Scopus till August 2023 for studies that compared ADT versus control for treating PCa reporting depression as outcome...
February 19, 2024: Prostate
https://read.qxmd.com/read/38353479/prostate-and-gut-any-relationship-a-narrative-review-on-the-available-evidence-and-putative-mechanisms
#19
REVIEW
Lorenzo Romano, Luigi Napolitano, Felice Crocetto, Carmine Sciorio, Marco De Sio, Agnese Miranda, Marco Romano, Kateryna Priadko
BACKGROUND: Gut microbiome is a community of microorganisms that lives in the human intestine and exerts various functions on the host, including metabolic, immunoregulatory, and control over cell proliferation. Gut microbiome alterations have been associated with various pathological conditions, such as diabetes mellitus, obesity, and cardiovascular diseases. Gut-prostate axis is explained by the association between gut microbiome quantitative and functional alterations along with increased intestinal epithelial permeability with prostatediseases...
February 14, 2024: Prostate
https://read.qxmd.com/read/38353033/nonantibiotic-strategies-to-decrease-the-postbiopsy-hospitalization-rates-because-of-infectious-complications-after-transrectal-prostate-biopsy
#20
JOURNAL ARTICLE
Coşkun Bostancı
OBJECTIVES: To compare the effect of biopsy needle disinfection with 10% formalin solution alone and with povidone-iodine rectal cleaning on preventing infectious complications requiring hospitalization. METHODS: The data of 902 patients who underwent prostate biopsy by transrectal route were retrospectively analyzed. Inclusion criteria were prophylactic antibiotic use and negative urine culture before the biopsy. Three groups occurred according to the methods used during the biopsy procedure...
February 14, 2024: Prostate
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