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Pediatric Pulmonology

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https://www.readbyqxmd.com/read/29766677/sleeping-child-neuroendocrine-cell-hyperplasia-of-infancy-and-polysomnography
#1
Deborah R Liptzin, Stephen M M Hawkins, Brandie D Wagner, Robin R Deterding
OBJECTIVES: Neuroendocrine cell hyperplasia of infancy (NEHI) is a children's interstitial and diffuse lung disease of unknown etiology that presents in infancy with characteristic findings of tachypnea, retractions, crackles, and hypoxemia. At the present, the mainstay of treatment is oxygen supplementation to normalize oxygen saturations and decrease work of breathing. There are characteristic pulmonary function, radiographic, and histologic findings, but polysomnography (PSG) data has not been reported...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29766676/identification-of-hospitalized-tracheostomy-and-ventilator-dependent-patients-in-administrative-data
#2
Barbara K Giambra, Colleen Mangeot, Dan T Benscoter, Maria T Britto
BACKGROUND: Patients with established tracheostomy and ventilator dependence are hospitalized more frequently and use more healthcare resources than other patients with complex chronic conditions. However, data to compare variation in hospitalization and resource use among patients in this population across the United States is deficient, partly due to the lack of structured methods to query national databases. AIM: Determine the best method for identifying the subset of children with established tracheostomy and ventilator dependence in Pediatric Health Information System (PHIS)...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29766674/assessment-of-airway-inflammation-and-remodeling-in-children-with-severe-asthma-the-next-challenge
#3
EDITORIAL
Guillaume Lezmi, Jacques de Blic
No abstract text is available yet for this article.
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29766672/ribcage-deformity-and-the-altered-breathing-pattern-in-children-with-osteogenesis-imperfecta
#4
Antonella LoMauro, Paolo Fraschini, Simona Pochintesta, Marianna Romei, Maria G D'Angelo, Andrea Aliverti
AIM: Osteogenesis Imperfecta (OI) is a genetic disease characterized by bones fragility and progressive deformity. Life expectancy is reduced in the non-lethal most severe type III form before the age of 10 years. The main cause of death in OI is respiratory insufficiency resulting from impaired thoracic function worsened by ribcage deformity and scoliosis. METHODS: We used opto-electronic plethysmography to study chest geometry, the ventilatory, and the thoraco-abdominal pattern at rest in supine position in children younger than 10 years...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29746013/accuracy-of-oscillatory-pressure-measured-by-mechanical-ventilators-during-high-frequency-oscillatory-ventilation-in-newborns
#5
Chiara Veneroni, Marta Tossici, Emanuela Zannin, Ilaria Milesi, Raffaele L Dellaca'
BACKGROUND: Oscillatory pressure (ΔP) measurement during high frequency oscillatory ventilation (HFOV) is technically challenging and influenced by all the components of the measurement system. OBJECTIVES: To evaluate the differences between the ΔP delivered at the inlet of the endotracheal tube and those displayed by commercial neonatal mechanical ventilators and monitoring devices and to characterize how the ventilator circuit and the flowmeter proximal to the patient affect these differences...
May 10, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29737017/pediatric-acute-respiratory-distress-syndrome-associated-with-human-metapneumovirus-and-respiratory-syncytial-virus
#6
Thyyar M Ravindranath, Amanda Gomez, Ilana Harwayne-Gidansky, Thomas J Connors, Nathan Neill, Bruce Levin, Joy D Howell, Lisa Saiman, John S Baird
OBJECTIVES: To study the incidence, risk factors, clinical course, and outcome of ARDS in children with HMP and RSV. WORKING HYPOTHESIS: We hypothesized that ARDS in children with HMP was similar in incidence, risk factors, clinical course, and outcomes to ARDS in children with RSV. STUDY DESIGN: Retrospective, observational study over 2 years. PATIENT-SUBJECT SELECTION: Patients included were <18 years old with HMP or RSV detected from nasopharyngeal specimens by commercial reverse transcriptase polymerase chain reaction assay admitted to a study site...
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29737005/2017-pediatric-pulmonology-year-in-review-part-2-neonatology
#7
Richard L Auten
The articles published in 2017 in topic areas relevant to neonatal pulmonology are reviewed in Part 2 of the Year-in-Review.
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29736958/benefits-of-pulmonary-rehabilitation-in-pediatric-asthma
#8
Stephen Kirkby, Allison Rossetti, Don Hayes, Elizabeth Allen, Shahid Sheikh, Benjamin Kopp, Alpa Patel
INTRODUCTION: There are limited studies evaluating the role of pulmonary rehabilitation (PR) in pediatric asthma. METHODS: A retrospective chart review was performed of all pediatric patients with a diagnosis of asthma enrolled in PR. Demographics, medications, and clinical records were reviewed. In addition, PFTs, 6-min walk test (6MWT), and patient/parent symptom and quality of life surveys before and after PR were evaluated. RESULTS: A total of 38 patients were enrolled in PR; 18 (47%) female and 20 (53%) male...
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29736909/epidemiology-of-robin-sequence-with-cleft-palate-in-the-east-of-scotland-between-2004-and-2013
#9
Marie Wright, Felicity Mehendale, Don S Urquhart
BACKGROUND: Robin sequence (RS) is a congenital disorder characterized by cleft palate, micrognathia, and glossoptosis which can result in clinically significant upper airway obstruction (UAO). Historically, incidence of RS in the UK has been estimated as 1 in 8500 live births. Our study describes birth prevalence, clinical characteristics, and management of RS in the East of Scotland (EoS) region. METHODS: Retrospective case note review of infants born in EoS from 2004 to 2013 with a clinical diagnosis of RS...
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29727521/microbiome-characteristics-of-induced-sputum-compared-to-bronchial-fluid-and-upper-airway-samples
#10
Shi-Qi An, Adilia Warris, Steve Turner
OBJECTIVE: The study of the community of microorganisms (the microbiota) in the lower airways in children is restricted to opportunistic sampling in children undergoing elective general anaesthetic. Here we tested the hypothesis that induced sputum is a valid alternative to directly sampling the lower airways to study lower airway microbiota. METHODS: Children scheduled for elective operations were recruited. Pre-operatively a sample of induced sputum was obtained...
May 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29727070/cystic-fibrosis-identification-and-frequency-of-mutations-in-a-mixed-population-from-a-low-income-region-in-northeastern-brazil
#11
LETTER
Laís R Mota, Lorena L de Castro, Tatiane da Anunciação Ferreira, Renata L L F de Lima, Maria Betânia P Toralles, Edna L Souza
No abstract text is available yet for this article.
May 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29717552/impact-of-a-cystic-fibrosis-transmembrane-conductance-regulator-cftr-modulator-on-high-dose-ibuprofen-therapy-in-pediatric-cystic-fibrosis-patients
#12
Brittany A Bruch, Sachinkumar B Singh, Laura J Ramsey, Timothy D Starner
BACKGROUND: This study was undertaken to determine if a clinically relevant drug-drug interaction occurred between ibuprofen and lumacaftor/ivacaftor. METHODS: Peak ibuprofen plasma concentrations were measured prior to and after lumacaftor/ivacaftor initiation. A Wilcoxon signed rank sum test was used to compare the values. RESULTS: Nine patients were included in the final analysis. Peak ibuprofen plasma concentrations decreased an average of 36...
May 1, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29717545/very-low-asthma-death-incidence-among-finnish-children-from-1999-to-2015
#13
Juho E Kivistö, Jussi Karjalainen, Laura Kivelä, Heini Huhtala, Jennifer L P Protudjer
BACKGROUND: The most recent reports concerning asthma fatalities in Finnish children are from 1998. Since that time, asthma care has improved and asthma-related hospitalizations have decreased. Yet, it is unknown whether pediatric asthma deaths have similarly decreased. OBJECTIVE: To investigate the epidemiology of asthma deaths in the Finnish pediatric population from 1999 onward and to describe the details of fatal asthma exacerbations. METHODS: We obtained copies of the death certificates from Statistics Finland of all Finnish children aged 0-19 years who died from asthma between 1999 and 2015...
May 1, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29701312/tidal-breath-eno-measurements-in-a-cohort-of-unsedated-hospitalized-neonates-a-method-validation
#14
Birgitte J Schmidt, Pauline S Reim, Andreas K Jensen, Per Albertsen, Gorm Greisen, Inger M Jørgensen
AIM: Exhaled Nitric oxide (eNO) is an inflammatory marker. In 2002 Hall et al. [J Appl Physiol. 92:59-66] established an infant eNO measurement method, fulfilling four criteria of feasibility: simple, non-invasive, without impact on the natural breathing pattern, and accounting for flow by NO output (V'NO). Although tidal breathing is accepted as an eNO measurement method in uncooperative patients, it is seldom used outside research labs. The variability and lack of validated methods have restrained from exploring the area in preterm and term neonates the last years...
April 27, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29696829/perspectives-of-adolescent-girls-with-cystic-fibrosis-and-parents-on-disease-specific-sexual-and-reproductive-health-education
#15
Traci M Kazmerski, Kelsey Hill, Olga Prushinskaya, Eliza Nelson, Jonathan Greenberg, Sarah Ab Pitts, Sonya Borrero, Elizabeth Miller, Gregory S Sawicki
INTRODUCTION: Adolescent girls with cystic fibrosis (CF) face significant disease-specific sexual and reproductive health (SRH) concerns that are not typically addressed in routine clinical care. Additionally, there is a paucity of developmentally appropriate CF-specific SRH educational resources for this population. The goal of this study was to explore patient and parent attitudes toward SRH educational resources for adolescent girls with CF. METHODS: Adolescent girls ages 13-18 years with CF and parents of daughters ages 10-18 years with CF completed individual, semi-structured interviews regarding their experiences and preferences around CF-specific SRH education and care...
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29696826/lung-ultrasound-compared-to-chest-x-ray-for-diagnosis-of-pediatric-pneumonia-a-meta-analysis
#16
REVIEW
Daniel S Balk, Christine Lee, Jesse Schafer, Jeremy Welwarth, John Hardin, Victor Novack, Shaked Yarza, Beatrice Hoffmann
OBJECTIVE: Although a clinical diagnosis, the standard initial imaging modality for patients with concern for pediatric community acquired pneumonia (pCAP) is a chest x-ray (CXR), which has a relatively high false negative rate, exposes patients to ionizing radiation, and may not be available in resource limited settings. The primary objective of this meta-analysis is to evaluate the accuracy of lung ultrasound (LUS) compared to CXR for the diagnosis of pCAP. METHODS: Data were collected via a systematic review of PubMed, EMBASE, and Web of Science with dates up to August 2017...
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29696825/endotracheal-or-tracheostomy-tube-occlusion-during-pediatric-flexible-bronchoscopy
#17
LETTER
Erin K Khan, Christopher D Baker
No abstract text is available yet for this article.
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29696817/pediatric-pulmonology-year-in-review-2017-part-4-sleep-medicine
#18
REVIEW
Ignacio E Tapia, Terry L Noah
Pediatric Pulmonology publishes original research, case reports and review articles on topics related to a wide range of children's respiratory disorders. In this article (Part 4 of a 5-part series), we summarize the past year's publications in sleep medicine, in the context of selected literature in this area from other journals. Articles are highlighted on topics including diagnosis and treatment of OSAS, sleep duration and position, and sleep disorders in chronic disease.
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29696807/case-report-giant-cystic-lesions-with-a-rare-pulmonary-diagnosis
#19
Ruth Siew, Eulalia R Y Cheng
A 14-year-old male who presented with back pain was found to have giant cystic lesions on CXR and emphysematous changes on chest CT. He underwent right lobectomies and histopathology of the resected lesions demonstrated giant bullous emphysema with placental transmogrification. This has not been previously described in a pediatric patient. We describe his clinical findings, pulmonary function tests, and post-operative course. The pathogenesis of placental transmogrification remains uncertain. As this is the first reported pediatric case, we propose that giant bullous emphysema with placental transmogrification should be considered in the differential diagnosis for cystic lesions in the pediatric age group...
April 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29687665/effect-of-continuous-positive-airway-pressure-on-breathing-variability-in-early-preterm-lung-disease
#20
Emanuela Zannin, Chiara Veneroni, Raffaele L Dellacà, Roberta Corbetta, Bela Suki, Paolo E Tagliabue, Maria L Ventura
OBJECTIVES: In preterm infants, the application of nasal Continuous Positive Airway Pressure (nCPAP) improves lung function through several mechanisms and may interact with the control of breathing. Our aim was to evaluate the effect of increasing/decreasing nCPAP on gas exchange, breathing pattern, and its variability in preterm infants. METHODS: Fifeteen infants with mild to moderate respiratory distress syndrome (RDS) were studied on the first day of life. Infants had a mean (SD) gestational age of 30 + 4 (3 + 4) weeks + day and body weight of 1405 (606) g...
April 23, 2018: Pediatric Pulmonology
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