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Pediatric Neurology

Alyssa M Day, Adrienne M Hammill, Csaba Juhász, Anna L Pinto, E Steve Roach, Charles E McCulloch, Anne M Comi
No abstract text is available yet for this article.
November 24, 2018: Pediatric Neurology
Lindsay Marie Malatesta, Debopam Samanta, Raghu Ramakrishnaiah
No abstract text is available yet for this article.
October 25, 2018: Pediatric Neurology
Debopam Samanta
No abstract text is available yet for this article.
October 25, 2018: Pediatric Neurology
Steven G Pavlakis
No abstract text is available yet for this article.
October 25, 2018: Pediatric Neurology
Ara Ko, Se Hee Kim, Se Hoon Kim, Eun Kyung Park, Kyu-Won Shim, Hoon-Chul Kang, Dong-Seok Kim, Heung Dong Kim, Joon Soo Lee
OBJECTIVE: Low-grade epilepsy-associated tumors (LEATs) are associated with childhood seizures that are typically drug-resistant, necessitating surgical interventions. In this study, we aimed to investigate the efficacy of surgical intervention in children with LEATs and to identify factors associated with seizure and cognitive outcomes. METHODS: We reviewed 58 children less than 18 years of age who underwent epilepsy surgery due to histopathologically confirmed LEATs and had a minimum postoperative follow-up duration of 24 months...
October 24, 2018: Pediatric Neurology
Daniel Cinelli, Caroline Lacroix, Kenneth A Myers
No abstract text is available yet for this article.
October 24, 2018: Pediatric Neurology
Jurriaan M Peters, Anna Prohl, Kush Kapur, Audrey Nath, Benoit Scherrer, Sean Clancy, Sanjay P Prabhu, Mustafa Sahin, David Neal Franz, Simon K Warfield, Darcy A Krueger
OBJECTIVE: We studied the longitudinal effects of everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), on callosal white matter diffusion tensor imaging (DTI) in patients with tuberous sclerosis complex (TSC). METHODS: Serial imaging data spanning nine years were used from the open label, Phase I/II trial (NCT00411619) and open-ended extension phase of everolimus for the treatment of subependymal giant cell astrocytoma associated with TSC. From 28 patients treated with everolimus and 25 untreated control patients, 481 MRI scans were available...
October 18, 2018: Pediatric Neurology
Gui-Fang Cao, Qi Bi
OBJECTIVE: We explored the relationship between pediatric infective endocarditis and stroke. PATIENTS AND METHODS: All children encountered with infective endocarditis from January 2002 to December 2015 were included as our sample, and their medical records were comprehensively reviewed. RESULTS: Sixty children with infective endocarditis were identified, including 30 boys and 30 girls aged eight months to 18 years (mean ± SD: 10.3 ± 5.6), and om 43 (71...
October 17, 2018: Pediatric Neurology
Nomazulu Dlamini, Prakash Muthusami, Catherine Amlie-Lefond
Moyamoya is a chronic, progressive steno-occlusive arteriopathy that typically affects the anterior circulation arteries of the circle of Willis. A network of deep thalamoperforating and lenticulostriate collaterals develop to by-pass the occlusion giving rise to the characteristic angiographic "puff of smoke" appearance. Moyamoya confers a lifelong risk of stroke and neurological demise, with peak age of presentation in childhood ranging between five and 10 years. Moyamoya disease refers to patients who do not have a comorbid condition, whereas moyamoya syndrome refers to patients in whom moyamoya occurs in association with an acquired or inherited disorder such as sickle cell disease, neurofibromatosis type-1 or trisomy 21...
October 15, 2018: Pediatric Neurology
Sophia French, Carter Wray
No abstract text is available yet for this article.
October 15, 2018: Pediatric Neurology
Lance M Relland, Alison Gehred, Nathalie L Maitre
BACKGROUND/GOAL: Assessment and treatment of neonatal pain is difficult because current scales are rarely validated against brain-based evidence. We sought to systematically evaluate published evidence to extract validation of the most promising markers of neonatal pain. METHODS: We searched four databases using germane MeSH terms. We focused on assessments of pain and/or nociception that had at least two measures among behavioral, physiological, or cortical components in preterm and/or term neonates...
October 10, 2018: Pediatric Neurology
Ryan Elizabeth Gill, Christopher Morrow, Eric Kossoff
No abstract text is available yet for this article.
October 9, 2018: Pediatric Neurology
Colby Hansen, Maya Battikha, Masaru Teramoto
OBJECTIVE: The aims of this study were: (1) to characterize mild traumatic brain injury (mTBI), mTBI with skull fracture, and complicated mTBI in school-aged children seen at a Level I pediatric trauma center and (2) to examine the nature of imaging findings seen in children with mTBI with skull fracture and those with complicated mTBI. METHODS: A total of 1777 pediatric patients (male: 1193 or 67.1%; age = 11.1 ± 3.5 years) sustaining mTBI who presented to the Emergency Department or directly to the trauma service in the years 2010 to 2013 were identified and classified into mTBI (n = 1,319 or 74...
October 6, 2018: Pediatric Neurology
Josef Finsterer
No abstract text is available yet for this article.
October 5, 2018: Pediatric Neurology
Ahmed BoAli, Kalthoum Tlili-Graiess, Amal AlHashem, Saad AlShahwan, Giulio Zuccoli, Brahim Tabarki
BACKGROUND: Mutations in AIMP1, which plays an important role in the development and maintenance of axon-cytoskeleton integrity and regulating neurofilaments, cause neurodegeneration of variable severity and white matter abnormalities. METHODS: From the patient records we analyzed the clinical evaluation, molecular genetics, neurodiagnostic, and neuroradiological investigations. RESULTS: We describe six members of a large consanguineous family with a phenotype of severe neurodegeneration in the form of developmental delays, progressive microcephaly, epilepsy, and failure to thrive...
September 25, 2018: Pediatric Neurology
Indar Kumar Sharawat, Renu Suthar
No abstract text is available yet for this article.
September 25, 2018: Pediatric Neurology
Abbas Rattani, Jaims Lim, Akshitkumar M Mistry, Marc A Prablek, Steven G Roth, Lori C Jordan, Chevis N Shannon, Robert P Naftel
INTRODUCTION: Epilepsy is a serious and often lifelong consequence of perinatal arterial ischemic stroke (PAIS). Variable incidences and risk factors for long-term epilepsy in PAIS have been reported. To determine the incidence of epilepsy in PAIS survivors and report factors associated with the risk of developing epilepsy, a meta-analysis and systematic review of prior publications was performed. METHODS: We examined studies on perinatal or neonatal patients (≤28 days of life) with arterial ischemic strokes in which the development of epilepsy was reported...
September 21, 2018: Pediatric Neurology
Mary Iype, Anish Ts, Pa Mohammed Kunju, Geetha Saradakutty, Mini Sreedharan, Shahanaz M Ahamed
OBJECTIVE: To study the long-term outcome of Acute disseminated encephalomyelitis (ADEM). METHODS: A retrospective cohort study was done among children diagnosed with ADEM (fulfilling IPMSSG criteria). Major outcome variables were motor deficit, scholastic underperformance and behavioral abnormality. RESULTS: The inclusion criteria were fulfilled by 102 children. Three died in hospital. The follow up ranged from 1-10 years (median 4 years)...
September 21, 2018: Pediatric Neurology
Amy Farkas, Ruba Al-Ramadhani, Kimberly McDonald, Meredith Jordan, David Joyner
No abstract text is available yet for this article.
September 21, 2018: Pediatric Neurology
Siddharth Srivastava, Benoit Scherrer, Anna K Prohl, Rajna Filip-Dhima, Kush Kapur, Alexander Kolevzon, Joseph D Buxbaum, Elizabeth Berry-Kravis, Latha Soorya, Audrey Thurm, Craig M Powell, Jonathan A Bernstein, Simon K Warfield, Mustafa Sahin
OBJECTIVE: Phelan-McDermid syndrome is caused by haploinsufficiency of SHANK3 on terminal chromosome 22. Knowledge about altered neuroanatomic circuitry in Phelan-McDermid syndrome comes from mouse models showing striatal hypertrophy in the basal ganglia, and from humans with evidence of cerebellar atrophy. To date, no studies have performed volumetric analysis on Phelan-McDermid syndrome patients. METHODS: We performed volumetric analysis on baseline brain MRIs of Phelan-McDermid syndrome patients (ages three to 21 years) enrolled in a prospective natural history study (ClinicalTrials...
September 21, 2018: Pediatric Neurology
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