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Pediatric Neurology

Satoru Ikemoto, Shin-Ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Kenjiro Kikuchi
BACKGROUND: Iodine 123 (I-123) iomazenil is a specific ligand of the central benzodiazepine receptor, which is a part of the postsynaptic gamma-aminobutyric acid A receptor complex. We performed statistical image processing of I-123 iomazenil single-photon emission computed tomography to elucidate maturational changes in the GABAergic system. METHODS: Thirty patients (18 boys and 12 girls, aged 17 days to 14 years) with cryptogenic focal epilepsy were enrolled and underwent I-123 iomazenil single-photon emission computed tomography...
April 3, 2018: Pediatric Neurology
Melisa Carrasco, Jamie Perin, Jacky M Jennings, Charlamaine Parkinson, Maureen M Gilmore, Raul Chavez-Valdez, An N Massaro, Raymond C Koehler, Frances J Northington, Aylin Tekes, Jennifer K Lee
BACKGROUND: Deviation of mean arterial blood pressure (MAP) from the range that optimizes cerebral autoregulatory vasoreactivity (optimal MAP) could increase neurological injury from hypoxic-ischemic encephalopathy (HIE). We tested whether a global magnetic resonance imaging (MRI) brain injury score and regional diffusion tensor imaging (DTI) are associated with optimal MAP in neonates with HIE. METHODS: Twenty-five neonates cooled for HIE were monitored with the hemoglobin volume index...
April 2, 2018: Pediatric Neurology
Marc R Del Bigio
No abstract text is available yet for this article.
March 9, 2018: Pediatric Neurology
David M Kaufman, N Paul Rosman
No abstract text is available yet for this article.
February 23, 2018: Pediatric Neurology
Marcelis Annelien, Verstraete Lieve
No abstract text is available yet for this article.
February 21, 2018: Pediatric Neurology
Lisa R Sun, Monica Pearl, Mona N Bahouth, Melisa Carrasco, Katherine Hoops, Jennifer Schuette, Ryan J Felling
No abstract text is available yet for this article.
February 14, 2018: Pediatric Neurology
Steven P Trau, William B Gallentine
No abstract text is available yet for this article.
February 13, 2018: Pediatric Neurology
Rilla E Schneider, Pamela Ng, Xun Zhang, John Andersen, David Buckley, Darcy Fehlings, Adam Kirton, Ellen Wood, Esias van Rensburg, Michael I Shevell, Maryam Oskoui
BACKGROUND: Advanced maternal age is associated with higher frequencies of antenatal and perinatal conditions, as well as a higher risk of cerebral palsy in offspring. We explore the association between maternal age and specific cerebral palsy risk factors. METHODS: Data were extracted from the Canadian Cerebral Palsy Registry. Maternal age was categorized as ≥35 years of age and less than 20 years of age at the time of birth. Chi-square and multivariate logistic regressions were performed to calculate odds ratios and their 95% confidence intervals...
February 12, 2018: Pediatric Neurology
E Sabroske, M D Svoboda, Y-T Ng
No abstract text is available yet for this article.
February 8, 2018: Pediatric Neurology
Lalit Bansal, Timothy P Zinkus, Alexander Kats
No abstract text is available yet for this article.
February 7, 2018: Pediatric Neurology
Edward Dabrowski, Marcin Bonikowski, Mark Gormley, Magali Volteau, Philippe Picaut, Mauricio R Delgado
BACKGROUND: The effects of botulinum toxin are transient, and repeat injections are required in children with lower-limb spasticity. However, the efficacy of botulinum toxin in patients who have received previous injections has remained largely unexplored. METHODS: We present subgroup analyses of a phase III study conducted in ambulatory children (aged two to 17) with spastic equinus foot. Patients were randomized to single doses of abobotulinumtoxinA 10 U/kg/leg, 15 U/kg/leg, or placebo injected into the gastrocnemius-soleus complex (one or both legs)...
February 7, 2018: Pediatric Neurology
Jorge Vidaurre, Dave Clarke, Edward Kija, Harry Chugani, Solomon L Moshé
No abstract text is available yet for this article.
February 1, 2018: Pediatric Neurology
Yefim Cavalier, Sanjeev V Kothare
No abstract text is available yet for this article.
January 31, 2018: Pediatric Neurology
Elaine Wirrell, Susan Eckert, Lily Wong-Kisiel, Eric Payne, Katherine Nickels
PURPOSE: This study evaluated tolerability and efficacy of the ketogenic diet in infants less than 12 months of age. METHODS: Infants <12 months of age, commencing the ketogenic diet between September 2007 and July 2016 were identified. Records were reviewed for epilepsy details, diet initiation details, efficacy and tolerability. RESULTS: Twenty-seven infants commenced the ketogenic diet (56% male, median age seven months). Median age at seizure onset was 1...
January 31, 2018: Pediatric Neurology
Loren Leclezio, Sugnet Gardner-Lubbe, Petrus J de Vries
BACKGROUND: Tuberous sclerosis complex (TSC) is a genetic disorder with multisystem involvement. The lifetime prevalence of TSC-Associated Neuropsychiatric Disorders (TAND) is in the region of 90% in an apparently unique, individual pattern. This "uniqueness" poses significant challenges for diagnosis, psycho-education, and intervention planning. To date, no studies have explored whether there may be natural clusters of TAND. The purpose of this feasibility study was (1) to investigate the practicability of identifying natural TAND clusters, and (2) to identify appropriate multivariate data analysis techniques for larger-scale studies...
January 31, 2018: Pediatric Neurology
Julianne D Schmidt, Katherine Rizzone, Nicole L Hoffman, Michelle L Weber, Courtney Jones, Jeff Bazarian, Steven P Broglio, Michael McCrea, Thomas W McAllister
BACKGROUND: Individuals who sustain their first concussion during childhood may be at greater risk of sustaining multiple concussions throughout their lifetime because of a longer window of vulnerability. This article aims to estimate the association between age at first concussion and number of subsequent concussions. PATIENTS AND METHODS: A total of 23,582 collegiate athletes from 26 universities and military cadets from three military academies completed a concussion history questionnaire (65% males, age 19...
January 31, 2018: Pediatric Neurology
Hossein Nazari, Austin S Nakatsuka, Mohamed Soliman
No abstract text is available yet for this article.
January 31, 2018: Pediatric Neurology
Ioannis Karakis, Sofia Georghiou, H Royden Jones, Basil T Darras, Peter B Kang
BACKGROUND: We analyzed the clinical and electrophysiologic patterns of nerve injury in pediatric patients with radial neuropathy. METHODS: This is a retrospective analysis of 19 children and adolescents with radial neuropathy. RESULTS: The mean subject age was 12 years (range one month to 19 years), 56% were female, and 53% had traumatic etiologies. Weakness in the finger and wrist extensors was the prevailing complaint (82%). Predominant localization was at the posterior interosseous nerve (37%), followed by the radial nerve below the spiral groove (32%), the radial nerve at the spiral groove (26%), and the radial nerve above the spiral groove (5%)...
January 31, 2018: Pediatric Neurology
Ryuki Matsuura, Shin-Ichiro Hamano, Takeo Iwamoto, Kenji Shimizu, Hirofumi Ohashi
No abstract text is available yet for this article.
January 31, 2018: Pediatric Neurology
Sarah B Mulkey, Gilbert Vezina, Dorothy I Bulas, Zarir Khademian, Anna Blask, Youssef Kousa, Caitlin Cristante, Lindsay Pesacreta, Adre J du Plessis, Roberta L DeBiasi
No abstract text is available yet for this article.
April 2018: Pediatric Neurology
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