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Pediatric Nephrology: Journal of the International Pediatric Nephrology Association

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https://www.readbyqxmd.com/read/30324507/a-clinical-predictive-model-of-renal-injury-in-children-with-congenital-solitary-functioning-kidney
#1
Isabel V Poggiali, Ana Cristina Simões E Silva, Mariana A Vasconcelos, Cristiane S Dias, Izabella R Gomes, Rafaela A Carvalho, Maria Christina L Oliveira, Sergio V Pinheiro, Robert H Mak, Eduardo A Oliveira
BACKGROUND: Solitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK. METHODS: In this retrospective cohort study, 162 patients with SFK were systematically followed up (median, 8.5 years). The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension, and chronic kidney disease (CKD)...
October 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30317433/common-clinical-markers-predict-end-stage-renal-disease-in-children-with-obstructive-uropathy
#2
Daryl J McLeod, Christina B Ching, Yuri V Sebastião, Jason H Greenberg, Susan L Furth, Kirk M McHugh, Brian Becknell
BACKGROUND: Obstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined. METHODS: Patients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases)...
October 13, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30315407/immunological-features-and-functional-analysis-of-anti-cfh-autoantibodies-in-patients-with-atypical-hemolytic-uremic-syndrome
#3
Wei-Yi Guo, Di Song, Xiao-Rong Liu, Zhi Chen, Hui-Jie Xiao, Jie Ding, Shu-Zhen Sun, Hong-Yan Liu, Su-Xia Wang, Feng Yu, Ming-Hui Zhao
OBJECTIVE: Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Anti-complement factor H (CFH) antibodies were thought to participate in the pathogenesis of aHUS. The aim of this study was to address the functions and properties of CFH autoantibodies in a Chinese Han cohort of aHUS patients. METHODS: Thirty-six anti-CFH antibody-positive aHUS patients at the acute phase of the disease were involved in this study. Clinical data of the patients were collected...
October 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30315406/iohexol-measured-glomerular-filtration-rate-in-children-and-adolescents-with-chronic-kidney-disease-a-pilot-study-comparing-venous-and-finger-stick-methods
#4
Amy Staples, Craig Wong, George J Schwartz
BACKGROUND: Measurement of glomerular filtration rate by iohexol disappearance (iGFR) has become a gold standard in the pediatric chronic kidney disease (CKD) population. The need for serial phlebotomy can be difficult and minimizing venipunctures would be beneficial. Furthermore, finger stick collection for dried blood spot (DBS) may be more tolerable in the pediatric population, and equivalence between these two methods may further simplify the process. METHODS: This was a cross-sectional study in children and adolescents 1 to 21 years with stages I-IV CKD...
October 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30315405/correction-to-acute-kidney-injury-in-neonatal-encephalopathy-an-evaluation-of-the-awaken-database
#5
Megan J Kirkley, Louis Boohaker, Russell Griffin, Danielle E Soranno, Jason Gien, David Askenazi, Katja M Gist
The original version of this article unfortunately contained a mistake. The collaborators of the Neonatal Kidney Collaborative (NKC) were not named individually. The list of all collaborators is given below.
October 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30291429/kidney-as-modulator-and-target-of-good-bad-hdl
#6
REVIEW
Jianyong Zhong, Haichun Yang, Valentina Kon
The strong inverse relationship between low levels of high-density lipoproteins (HDLs) and atherosclerotic cardiovascular disease (CVD) led to the designation of HDL as the "good" cholesterol. The atheroprotection is thought to reflect HDL's capacity to efflux cholesterol from macrophages, followed by interaction with other lipoproteins in the plasma, processing by the liver and excretion into bile. However, pharmacologic increases in HDL-C levels have not led to expected clinical benefits, giving rise to the concept of dysfunctional HDL, in which increases in serum HDL-C are not beneficial due to lost or altered HDL functions and transition to "bad" HDL...
October 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30291428/hyperphosphatemia-in-an-11-year-old-girl-with-acute-myeloid-leukemia-answers
#7
Monique Albersen, Arend Bökenkamp, Hans Schotman, Stephanie Smetsers
No abstract text is available yet for this article.
October 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30291427/hyperphosphatemia-in-an-11-year-old-girl-with-acute-myeloid-leukemia-questions
#8
Monique Albersen, Arend Bökenkamp, Hans Schotman, Stephanie Smetsers
No abstract text is available yet for this article.
October 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30284023/lisinopril-versus-lisinopril-and-losartan-for-mild-childhood-iga-nephropathy-a-randomized-controlled-trial-jskdc01-study
#9
Yuko Shima, Koichi Nakanishi, Mayumi Sako, Mari Saito-Oba, Yuko Hamasaki, Hiroshi Hataya, Masataka Honda, Koichi Kamei, Kenji Ishikura, Shuichi Ito, Hiroshi Kaito, Ryojiro Tanaka, Kandai Nozu, Hidefumi Nakamura, Yasuo Ohashi, Kazumoto Iijima, Norishige Yoshikawa
BACKGROUND: Persistent proteinuria seems to be a risk factor for progression of renal disease. Its reduction by angiotensin-converting inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) is renoprotective. Our previous pilot study showed that 2-year lisinopril therapy is effective and safe for children with mild IgA nephropathy. When combined with ACEI and ARB, reported results are of greater decrease in proteinuria than monotherapy in chronic glomerulonephritis, including IgA nephropathy...
October 3, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30280213/treatment-of-steroid-resistant-nephrotic-syndrome-in-the-genomic-era
#10
REVIEW
Adam R Bensimhon, Anna E Williams, Rasheed A Gbadegesin
The pathogenesis of steroid-resistant nephrotic syndrome (SRNS) is not completely known. Recent advances in genomics have elucidated some of the molecular mechanisms and pathophysiology of the disease. More than 50 monogenic causes of SRNS have been identified; however, these genes are responsible for only a small fraction of SRNS in outbred populations. There are currently no guidelines for genetic testing in SRNS, but evidence from the literature suggests that testing should be guided by the genetic architecture of the disease in the population...
October 2, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30276536/comparison-of-echocardiographic-changes-in-children-with-primary-hypertension-and-hypertension-due-to-mild-to-moderate-chronic-kidney-disease
#11
Gabriel Paris, Sudheer R Gorla, Aura J Arenas-Morales, Wacharee Seeherunvong, Sethuraman Swaminathan
BACKGROUND: Chronic systemic hypertension has a well-known association with increased cardiovascular morbidity and mortality. One of the most important target organs affected in systemic hypertension is the heart. In addition, chronic kidney disease (CKD) further increases the mortality from cardiovascular disease. The aim of this study was to evaluate the differences in the cardiovascular changes in pediatric patients with primary hypertension (pHTN) vs. those with secondary hypertension from chronic kidney disease (CKD-HTN)...
October 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30276535/even-gold-standard-methods-of-body-water-measurement-are-not-always-in-perfect-agreement
#12
LETTER
Indranil Dasgupta, David Keane, Ulrich Moissl, Elizabeth Lindley
No abstract text is available yet for this article.
October 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30276534/towards-adulthood-with-a-solitary-kidney
#13
Pierre Cochat, Olivia Febvey, Justine Bacchetta, Etienne Bérard, Natalia Cabrera, Laurence Dubourg
Around 1/1000 people have a solitary kidney. Congenital conditions mainly include multicystic dysplastic kidney and unilateral renal aplasia/agenesis; acquired conditions are secondary to nephrectomy performed because of urologic structural abnormalities, severe parenchymal infection, renal trauma, and renal or pararenal tumors. Children born with congenital solitary kidney have a better long-term glomerular filtration rate than those with solitary kidney secondary to nephrectomy later in life. Acute and chronic adaptation processes lead to hyperfiltration followed by fibrosis in the remnant kidney, with further risk of albuminuria, arterial hypertension, and impaired renal function...
October 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30276533/hypertensive-crisis-in-children-and-adolescents
#14
Tomáš Seeman, Gilad Hamdani, Mark Mitsnefes
Hypertensive crisis is a relatively rare condition in children. However, if not treated, it might be life-threatening and lead to irreversible damage of vital organs. Clinical presentation of patients with hypertensive crisis can vary from very mild (hypertensive urgency) to severe symptoms (hypertensive emergency) despite similarly high blood pressure (BP). Individualized assessment of patients presenting with high BP with emphasis on the evaluation of end-organ damage rather than on the specific BP number is a key in guiding physician's initial management of a hypertensive crisis...
October 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30276532/skin-microvascular-dysfunction-as-an-early-cardiovascular-marker-in-primary-hyperoxaluria-type-i
#15
Alexandra Bruel, Justine Bacchetta, Tiphanie Ginhoux, Christelle Rodier-Bonifas, Anne-Laure Sellier-Leclerc, Bérengère Fromy, Pierre Cochat, Dominique Sigaudo-Roussel, Laurence Dubourg
BACKGROUND: Primary hyperoxaluria type 1 (PH1) is an orphan inborn error of oxalate metabolism leading to hyperoxaluria, progressive renal failure, oxalate deposition, and increased cardiovascular complications. As endothelial dysfunction and arterial stiffness are early markers of cardiovascular risk, we investigated early endothelial and vascular dysfunction in young PH1 patients either under conservative treatment (PH1-Cons) or after combined kidney liver transplantation (PH1-T) in comparison to healthy controls (Cont-H) and patients with a past of renal transplantation (Cont-T)...
October 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30267239/racial-ethnic-differences-in-chronic-kidney-disease-mineral-bone-disorder-in-youth-on-dialysis
#16
Marciana Laster, Melissa Soohoo, Elani Streja, Robert Elashoff, Stephanie Jernigan, Craig B Langman, Keith C Norris, Isidro B Salusky, Kamyar Kalantar-Zadeh
BACKGROUND: Studies in healthy pediatric populations and adults treated with dialysis demonstrate higher parathyroid hormone (PTH) and lower 25-hydroxyvitamin D levels in African-Americans. Despite these findings, African-Americans on dialysis demonstrate greater bone strength and a decreased risk of fracture compared to the Caucasian dialysis population. The presence of such differences in children and young adult dialysis patients is unknown. METHODS: Differences in the markers of mineral and bone metabolism (MBM) were assessed in 661 incident dialysis patients (aged 1 month to < 21 years)...
September 29, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30267238/b-cell-phenotype-in-pediatric-idiopathic-nephrotic-syndrome
#17
Manuela Colucci, Rita Carsetti, Simona Cascioli, Jessica Serafinelli, Francesco Emma, Marina Vivarelli
BACKGROUND: A pathogenic role of B cells in non-genetic nephrotic syndrome has been suggested by the efficacy of rituximab, a B cell depleting antibody, in maintaining a prolonged remission. However, little information is available on B cell homeostasis in nephrotic syndrome patients. METHODS: We retrospectively analyzed by flow cytometry the distribution of different B cell subpopulations in 107 steroid-sensitive and in 6 genetic steroid-resistant nephrotic syndrome pediatric patients, compared with age- and sex-matched controls...
September 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30264215/predictors-of-patency-for-arteriovenous-fistulae-and-grafts-in-pediatric-hemodialysis-patients
#18
Ali Mirza Onder, Joseph T Flynn, Anthony A Billings, Fang Deng, Marissa DeFreitas, Chryso Katsoufis, Matthew M Grinsell, Larry T Patterson, Jennifer Jetton, Sahar Fathallah-Shaykh, Daniel Ranch, Diego Aviles, Lawrence Copelovitch, Eileen Ellis, Vimal Chanda, Ayah Elmaghrabi, Jen-Jar Lin, Lavjay Butani, Maha Haddad, Olivera Marsenic Couloures, Paul Brakeman, Raymond Quigley, H Stella Shin, Rouba Garro, Hui Liu, Javad Rahimikollu, Rupesh Raina, Craig B Langman, Ellen G Wood
BACKGROUND: Hemodialysis (HD) guidelines recommend permanent vascular access (PVA) in children unlikely to receive kidney transplant within 1 year of starting HD. We aimed to determine predictors of primary and secondary patency of PVA in pediatric HD patients. METHODS: Retrospective chart reviews were performed for first PVAs in 20 participating centers. Variables collected included patient demographics, complications, interventions, and final outcome. RESULTS: There were 103 arterio-venous fistulae (AVF) and 14 AV grafts (AVG)...
September 27, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30259113/an-8-year-old-with-genu-valgum-answers
#19
Kishan Srikanth, Poyyapakkam R Srivaths, Shweta Shah
No abstract text is available yet for this article.
September 26, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30259112/an-8-year-old-with-genu-valgum-questions
#20
Kishan Srikanth, Poyyapakkam R Srivaths, Shweta Shah
No abstract text is available yet for this article.
September 26, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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