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Pediatric Diabetes

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https://www.readbyqxmd.com/read/28326652/paediatric-type-2-diabetes-in-china-pandemic-progression-and-potential-solutions
#1
REVIEW
Qing Ye, Jun-Fen Fu
China is gradually taking its place as one of the world's economic giants and concurrently learning to cope with the burden of diseases that are more common in the developed world, such as paediatric type 2 diabetes mellitus. The prevalence of type 2 diabetes has been recently observed among children and adolescents in China; hence, there is a lack of information about the incidence, prevalence, pathogenesis, and pathophysiology of the disease. Diagnosis, treatment, and management have been standardized to a large degree, but there is still a need for data regarding optimal management protocols and how to achieve the best control over current state of the disease...
March 22, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28318089/a-cacna1d-mutation-in-a-patient-with-persistent-hyperinsulinaemic-hypoglycaemia-heart-defects-and-severe-hypotonia
#2
S E Flanagan, F Vairo, M B Johnson, R Caswell, T W Laver, H Lango Allen, K Hussain, S Ellard
Congenital hyperinsulinaemic hypoglycaemia (HH) can occur in isolation or it may present as part of a wider syndrome. For approximately 40%-50% of individuals with this condition, sequence analysis of the known HH genes identifies a causative mutation. Identifying the underlying genetic aetiology in the remaining cases is important as a genetic diagnosis will inform on recurrence risk, may guide medical management and will provide valuable insights into β-cell physiology. We sequenced the exome of a child with persistent diazoxide-responsive HH, mild aortic insufficiency, severe hypotonia, and developmental delay as well as the unaffected parents...
March 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28318073/self-and-parent-reported-executive-problems-in-adolescents-with-type-1-diabetes-are-associated-with-poor-metabolic-control-and-low-physical-activity
#3
Charlotte Nylander, Ylva Tindberg, Josephine Haas, Ingemar Swenne, Torun Torbjörnsdotter, Karin Åkesson, Eva Örtqvist, Jan Gustafsson, Elisabeth Fernell
BACKGROUND: Management of diabetes is demanding and requires efficient cognitive skills, especially in the domain of executive functioning. However, the impact of impaired executive functions on diabetes control has been studied to a limited extent. The aim of the study is to investigate the association between executive problems and diabetes control in adolescents with type 1 diabetes. MATERIALS AND METHODS: Two hundred and forty-one of 477 (51%) of 12- to 18-year-old adolescents, with a diabetes duration of >2 years in Stockholm, Uppsala, and Jönköping participated...
March 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28303678/schooling-diabetes-use-of-continuous-glucose-monitoring-and-remote-monitors-in-the-home-and-school-settings
#4
Christine Erie, Michelle A Van Name, Kate Weyman, Stuart A Weinzimer, Jennifer Finnegan, Kristin Sikes, William V Tamborlane, Jennifer L Sherr
BACKGROUND: Despite significant advances in type 1 diabetes (T1D) management, achieving targeted glycemic control in pediatric patients remains a struggle. Continuous glucose monitoring (CGM) with remote access holds the promise to address this challenge by allowing caregivers to monitor glucose, even when the child is not directly under their supervision. OBJECTIVE: To explore real-time and remote CGM practices in homes and schools, including caregiver expectations regarding this technology...
March 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28271591/a-novel-heterozygous-mutation-of-the-wfs1-gene-leading-to-constitutive-endoplasmic-reticulum-stress-is-the-cause-of-wolfram-syndrome
#5
Shuntaro Morikawa, Toshihiro Tajima, Akie Nakamura, Katsura Ishizu, Tadashi Ariga
BACKGROUND: Wolfram syndrome (WS) is a disorder characterized by the association of insulin-dependent diabetes mellitus (DM), diabetes insipidus, deafness, and optic nerve atrophy. WS is caused by WFS1 mutations encoding WFS1 protein expressed in endoplasmic reticulum (ER). During ER protein synthesis, misfolded and unfolded proteins accumulate, known as "ER stress". This is attenuated by the unfolded protein response (UPR), which recovers and maintains ER functions. Because WFS1 is a UPR component, mutant WFS1 might cause unresolvable ER stress conditions and cell apoptosis, the major causes underlying WS symptoms...
March 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28271589/clustering-of-cardio-metabolic-risk-factors-in-parents-of-adolescents-with-type-1-diabetes-and-microalbuminuria
#6
M Loredana Marcovecchio, Päivi H Tossavainen, Katharine Owen, Catherine Fullah, Paul Benitez-Aguirre, Stefano Masi, Ken Ong, Helen Nguyen, Scott T Chiesa, R Neil Dalton, John Deanfield, David B Dunger
OBJECTIVE: To evaluate the association between a clustering of cardio-metabolic risk factors in parents and the development of microalbuminuria (MA) in their offspring with childhood-onset type 1 diabetes (T1D). METHODS: The study population comprised 53 parents (mean age [±SD]: 56.7±6.2 years) of 35 T1D young people with MA (MA+) and 86 parents (age: 56.1±6.3 years) of 50 matched offspring with normoalbuminuria (MA-), who underwent clinical, biochemical and cardiovascular imaging assessments...
March 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28261940/establishing-the-feasibility-of-a-community-and-primary-health-care-intervention-to-raise-awareness-of-symptoms-of-type-1-diabetes-the-early-detection-of-type-1-diabetes-in-youth-eddy-study
#7
J Townson, J W Gregory, L Cowley, D Gallagher, S Channon, M Robling, D Williams, C Hughes, S Murphy, L Lowes
AIMS: To design, develop, and evaluate the feasibility of delivering a multi-component community based intervention to parents and primary health care professionals to raise awareness of the symptoms of Type 1 diabetes (T1D) in childhood in 3 adjoining borough counties of South Wales. MATERIALS AND METHODS: Parent and primary health care advisory groups were established to design the intervention. Qualitative interviews with stakeholders and parents assessed the acceptability, feasibility and any potential impact of the intervention...
March 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28261934/steroid-induced-impairment-of-glucose-tolerance-prevalence-among-pediatric-patients-on-long-term-steroid-use-in-nigeria
#8
U N Chikani, M U Ibekwe, T Oguonu, L Mungai, A I Bisi-Onyemaechi, O M Ugege, I F Ogbonna, Carine de Beaufort
INTRODUCTION: Glucocorticoid (referred to from here on as simply steroid) is used for effective treatment of various inflammatory disorders since its discovery in 1940s. However, these useful drugs cause important side effects, such as impairment of glucose tolerance. We sought to determine the prevalence of steroid-induced impairment of glucose tolerance in pediatric patients on long-term steroid use. MATERIALS AND METHODS: A cross-sectional, descriptive and hospital-based study...
March 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28251726/outcomes-of-algorithm-based-modifications-of-insulinotherapy-during-exercise-in-mdi-vs-insulin-pump-treated-children-with-type-1-diabetes-results-from-the-tread-diab-study
#9
S Moniotte, M Owen, T Barrea, A Robert, P A Lysy
OBJECTIVES: To evaluate the evolution of subcutaneous glucose (SG) after a standardized aerobic exercise in children and adolescents treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injection (MDI) regimen before and after adaptation of insulin doses. RESEARCH DESIGN AND METHODS: Eleven CSII- and 13 MDI-treated patients performed 2 30-minute sessions of moderate to vigorous (70% of age-based maximal heart rate) exercise on a treadmill under continuous glucose monitoring (CGM)...
March 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28239959/type-1-diabetes-in-children-and-adolescents-is-not-associated-with-a-reduced-prevalence-of-atopy-and-allergic-diseases
#10
Hildegard Jasser-Nitsche, Eva-Maria Varga, Helmuth Martin Borkenstein, Julia Höntzsch, Elisabeth Suppan, Gudrun Weinhandl, Lisa Pieringer, Alexander Avian, Elke Fröhlich-Reiterer
BACKGROUND: Type 1 diabetes mellitus (T1D) as well as allergies in childhood have increased worldwide during the last 2 decades. The reasons for this increase are still unknown but early life origins are being discussed, such as dietary and hygiene factors that may play a role in the development of both diseases. The aim of this study was to compare the prevalence of allergies in children with and without T1D and to define potential influencing factors. MATERIALS AND METHODS: Data were collected from 104 patients with T1D (n = 104; mean age 11...
February 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28181734/molecular-mechanisms-of-insulin-resistance-in-2-cases-of-primary-insulin-receptor-defect-associated-diseases
#11
Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio
BACKGROUND: Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality during the infantile period is caused by biallelic defects of INSR . MATERIALS AND METHODS: We detected 2 missense mutations in 2 cases of leprechaunism and IRAN, type A, and reduced mRNA expression in the leprechaunism case...
February 9, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28176415/visceral-fat-is-associated-with-the-racial-differences-in-liver-fat-between-black-and-white-adolescent-boys-with-obesity
#12
SoJung Lee, Jennifer L Kuk
OBJECTIVE: We examined whether racial differences in liver fat are associated with the differences in abdominal fat distribution or cardiorespiratory fitness (CRF). METHODS: Participants included 57 black and white obese boys (12-18 years). Total and abdominal fat was measured by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging, respectively. CRF was measured using a maximal graded treadmill test with the use of standard open-circuit spirometry techniques until volitional fatigue...
February 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28165182/a-severe-case-of-hyperinsulinism-due-to-hemizygous-activating-mutation-of-glutamate-dehydrogenase
#13
Mary Barrosse-Antle, Chang Su, Pan Chen, Kara E Boodhansingh, Thomas J Smith, Charles A Stanley, Diva D De León, Changhong Li
Activating mutations in the GLUD1 gene, which encodes glutamate dehydrogenase (GDH), result in the hyperinsulinism-hyperammonemia syndrome. GDH is an allosterically regulated enzyme responsible for amino acid-mediated insulin secretion via the oxidative deamination of glutamate to 2-oxoglutarate, leading to ATP production and insulin release. This study characterizes a novel combination of mutations in GLUD1 found in a neonate who presented on the first day of life with severe hypoglycemia, hyperammonemia, and seizures...
February 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28165180/faster-acting-insulin-aspart-provides-faster-onset-and-greater-early-exposure-vs-insulin-aspart-in-children-and-adolescents-with-type-1-diabetes-mellitus
#14
Maryam Fath, Thomas Danne, Torben Biester, Lars Erichsen, Olga Kordonouri, Hanne Haahr
BACKGROUND: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM: This randomized, double-blind, 2-period crossover trial investigated the pharmacological properties of faster aspart vs IAsp in 12 children (6-11 years), 13 adolescents (12-17 years), and 15 adults (18-64 years) with type 1 diabetes mellitus...
February 6, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28156056/diabetes-camp-matters-assessing-families-views-of-their-diabetes-camp-experience
#15
Jill Weissberg-Benchell, Karen Rychlik
BACKGROUND: Camp offers a safe and fun environment for learning new information about diabetes care and for trying new self-care skills. It is a place where children and teens are able to meet with others who also have diabetes and who share their experiences. MATERIALS AND METHODS: This study assessed self-reports before and after attending diabetes camp on diabetes-specific emotional distress, diabetes-specific quality of life, and self-care behaviors by surveying campers and their parents from over 42 diabetes-specific summer camps across the United States...
February 3, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28145083/the-effect-of-adding-metformin-to-insulin-therapy-for-type-1-diabetes-mellitus-children-a-systematic-review-and-meta-analysis
#16
REVIEW
Reem A Al Khalifah, Abdulrahman Alnhdi, Hassan Alghar, Mohammad Alanazi, Ivan D Florez
We aimed to assess the effectiveness of adding metformin to insulin in type 1 diabetes mellitus (T1DM) children for improving metabolic outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) conducted on children age 6 to 19 years who are diagnosed with T1DM, and examined the effect of adding Metformin to standard insulin therapy. We performed literature searches on Ovid Midline, Ovid Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from the date of inception of the database to February 15, 2016...
February 1, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28145026/self-reported-regular-alcohol-consumption-in-adolescents-and-emerging-adults-with-type-1-diabetes-a-neglected-risk-factor-for-diabetic-ketoacidosis-multicenter-analysis-of-29-630-patients-from-the-dpv-registry
#17
Julia M Hermann, Michael Meusers, Rainer Bachran, Ursula Kuhnle-Krahl, Norbert Jorch, Sabine E Hofer, Reinhard W Holl
BACKGROUND: The risk of hypoglycemia increases after alcohol consumption in patients with type 1 diabetes. This study aimed to investigate the association between metabolic control and self-reported alcohol consumption in young patients with type 1 diabetes. MATERIALS AND METHODS: N = 29 630 patients with type 1 diabetes aged 12 to <30 years (median age 17.0 [14.9, 18.3] years, duration of diabetes 6.8 [3.3, 10.9] years, 53% male) from the German/Austrian DPV registry were analyzed...
February 1, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28145023/low-muscle-mass-is-associated-with-cardiometabolic-risk-regardless-of-nutritional-status-in-adolescents-a-cross-sectional-study-in-a-chilean-birth-cohort
#18
R Burrows, P Correa-Burrows, M Reyes, E Blanco, C Albala, S Gahagan
BACKGROUND: Increased cardiometabolic risk (CMR) is documented in obese and non-obese adolescents with low muscular fitness. However, the association of low muscle mass (LMM) with CMR, independent of weight status, has not been examined. We analyzed the relationship of LMM with CMR in adolescents, regardless of their weight status. MATERIALS AND METHODS: Observational study in 660 adolescents. BMI, waist circumference (WC), arterial blood pressures (ABP) were measured...
February 1, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28133885/impact-of-quality-of-life-qol-on-glycemic-control-hba1c-among-adolescents-and-emerging-adults-with-long-duration-type-1-diabetes-a-prospective-cohort-study
#19
Anna Stahl-Pehe, Sandra Landwehr, Karin S Lange, Christina Bächle, Katty Castillo, Rhuphine Yossa, Jana Lüdtke, Reinhard W Holl, Joachim Rosenbauer
OBJECTIVE: To evaluate the impact of self-reported chronic-generic and condition-specific quality of life (QoL) on glycemic control among adolescents and emerging adults with long-duration type 1 diabetes (T1D) in a longitudinal design. METHODS: The database used was a nationwide cohort study of patients with ≥10 years T1D duration at baseline in Germany. The baseline questionnaire survey was conducted in 2009-2010, the follow-up survey in 2012-2013; additional clinical data of routine care procedures were linked...
January 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28127835/residual-beta-cell-function-in-diabetes-children-followed-and-diagnosed-in-the-teddy-study-compared-to-community-controls
#20
Andrea K Steck, Helena Elding Larsson, Xiang Liu, Riitta Veijola, Jorma Toppari, William A Hagopian, Michael J Haller, Simi Ahmed, Beena Akolkar, Åke Lernmark, Marian J Rewers, Jeffrey P Krischer
OBJECTIVE: To explore whether children diagnosed with type 1 diabetes during islet autoantibody surveillance through The Environmental Determinants of Diabetes in the Young (TEDDY) study retain greater islet function than children diagnosed through the community. METHODS: TEDDY children identified at birth with high-risk human leukocyte antigen and followed every 3 months until diabetes diagnosis were compared to age-matched children diagnosed with diabetes in the community...
January 27, 2017: Pediatric Diabetes
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