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Pediatric Diabetes

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https://www.readbyqxmd.com/read/28809093/caregiving-for-children-with-type-1-diabetes-and-clinical-outcomes-in-central-india-the-idream-study
#1
Greta Friedemann-Sánchez, Benjamin D Capistrant, James Ron, Lindsey Novak, Caroline Zuijdwijk, Graham D Ogle, Barbara Anderson, Antoinette Moran, Sharad Pendsey
AIMS: Parental care influences outcomes for children's type 1 diabetes (T1D). There is little evidence about the impact of parental caregiving in developing countries, where fixed dose human insulin (conventional) therapy and limited self-monitoring of blood glucose are common. This article investigates whether performance of key T1D management tasks by children or their caregivers impacts hemoglobin A1c (HbA1c). METHODS: We surveyed the caregivers of 179 children with T1D routinely treated in a specialized diabetes clinic in Maharashtra, India to determine who performs key diabetes care tasks: child or parent...
August 15, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28791793/early-transition-from-insulin-to-sulfonylureas-in-neonatal-diabetes-and-follow-up-experience-from-china
#2
Xiuzhen Li, Aijing Xu, Huiying Sheng, Tzer Hwu Ting, Xiaojian Mao, Xinjiang Huang, Minyan Jiang, Jing Cheng, Li Liu
BACKGROUND: Sulfonylurea therapy can improve glycemic control and ameliorate neurodevelopmental outcomes in patients suffering from neonatal diabetes mellitus (NDM) with KCNJ11 or ABCC8 mutations. As genetic testing results are often delayed, it remains controversial whether sulfonylurea treatment should be attempted immediately at diagnosis or doctors should await genetic confirmation. OBJECTIVE: This study aimed to investigate the effectiveness and safety of sulfonylurea therapy in Chinese NDM patients during infancy before genetic testing results were available...
August 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28782293/systematic-review-of-publicity-interventions-to-increase-awareness-amongst-healthcare-professionals-and-the-public-to-promote-earlier-diagnosis-of-type-1-diabetes-in-children-and-young-people
#3
R Deylami, J Townson, M Mann, J W Gregory
BACKGROUND: Children with new onset type 1 diabetes (T1D) are at risk of developing the life-threatening condition ketoacidosis if they have a delayed diagnosis. The rate of children presenting in ketoacidosis remains high in a number of countries worldwide. To ensure interventions to raise awareness of symptoms are effective a systematic review was conducted to evaluate previous publicity campaigns. METHODS: A range of databases was searched using search terms relating to T1D, publicity campaigns, and symptom awareness...
August 7, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28758314/child-and-parental-executive-functioning-in-type-1-diabetes-their-unique-and-interactive-role-toward-treatment-adherence-and-glycemic-control
#4
Eveline R Goethals, Maartje de Wit, Nady Van Broeck, Jurgen Lemiere, Dagmar Van Liefferinge, Susanne Böhler, Marian De Wulf, Elke Dello, Jolien Laridaen, Lynn Van Hecke, Shana Van Impe, Kristina Casteels, Koen Luyckx
OBJECTIVE: Managing type 1 diabetes (T1D) requires the ability to make complex and critical decisions regarding treatment, to execute complex tasks accurately, and to make adjustments when problems arise. This requires effective neuropsychological competences of patients and their families, especially in the domain of executive functioning (EF): the ability to self-monitor, plan, solve problems, and set priorities. Previous research focused mainly on child EF, neglecting the impact of parental EF...
July 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28749076/serum-and-gene-expression-levels-of-ct-1-il-6-and-tnf-%C3%AE-after-a-lifestyle-intervention-in-obese-children
#5
A Marti, L Morell-Azanza, T Rendo-Urteaga, S García-Calzón, A Ojeda-Rodríguez, N Martín-Calvo, M J Moreno-Aliaga, J A Martínez, M C Azcona-San Julián
BACKGROUND: Inflammation related molecules such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation-related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week lifestyle intervention in obese children and asses their potential association with glucose metabolism...
July 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28745034/transglutaminase-antibodies-and-celiac-disease-in-children-with-type-1-diabetes-and-in-their-family-members
#6
Anna Parkkola, Taina Härkönen, Samppa J Ryhänen, Raivo Uibo, Jorma Ilonen, Mikael Knip
OBJECTIVES: We set out to determine the prevalence of tissue transglutaminase antibodies (anti-tTG) and celiac disease (CD) in children with newly diagnosed type 1 diabetes (T1D) and their first-degree relatives (FDR). The hypothesis was that the individuals with both diabetes and CD form a distinct subgroup in terms of human leukocyte antigen (HLA) class II genetics, islet autoantibodies, and clinical characteristics at diabetes diagnosis. SUBJECTS AND METHODS: This population-based observational study included 745 index children with T1D and their 2692 FDR from the Finnish Pediatric Diabetes Register...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28744992/the-effect-of-12-weeks-carnosine-supplementation-on-renal-functional-integrity-and-oxidative-stress-in-pediatric-patients-with-diabetic-nephropathy-a-randomized-placebo-controlled-trial
#7
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Abdel Rahman El-Naggar, Mahitab Hany Hamouda, Manal El-Hamamsy
BACKGROUND AND OBJECTIVES: Oxidative stress is a significant contributor to the pathogenesis of diabetic nephropathy. Carnosine is a natural radical oxygen species scavenger. We investigated the effect of carnosine as an adjuvant therapy on urinary albumin excretion (UAE), the tubular damage marker alpha 1-microglobulin (A1M), and oxidative stress in pediatric patients with type 1 diabetes and nephropathy. METHODS: This randomized placebo-controlled trial included 90 patients with diabetic nephropathy, despite oral angiotensin-converting enzyme inhibitors (ACE-Is), who were randomly assigned to receive either 12 weeks of carnosine 1 g/day (n = 45), or matching placebo (n = 45)...
July 26, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28737266/nephrolithiasis-a-complication-of-pediatric-diabetic-ketoacidosis
#8
Sungeeta Agrawal, Robin Kremsdorf, Serife Uysal, Meghan E Fredette, Lisa Swartz Topor
OBJECTIVE: To determine the frequency of nephrolithiasis as a complication of diabetic ketoacidosis (DKA) in pediatrics. METHODS: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January 2009 and July 2016. We identified patients with nephrolithiasis during admission for DKA. RESULTS: We identified 395 episodes of DKA over 7.5 years. Nephrolithiasis developed as a complication of DKA in 3 of those admissions (0...
July 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28726334/insulin-sensitivity-across-the-lifespan-from-obese-adolescents-to-obese-adults-with-impaired-glucose-tolerance-who-is-worse-off
#9
Silva Arslanian, Joon Young Kim, Alexis Nasr, Fida Bacha, Hala Tfayli, SoJung Lee, Frederico G S Toledo
OBJECTIVE: Youth type 2 diabetes mellitus (T2DM) occurs decades earlier than adult T2DM and is characterized by high therapeutic failure rates and decreased response to insulin sensitizers suggesting a more severe disease process than in adults. To explain these observations, we hypothesized that insulin resistance is worse in obese youth than adults with impaired glucose tolerance (IGT), a state of high-risk for T2DM. As proof-of-concept, we compared insulin sensitivity between BMI-, sex-, and race-matched obese youth vs adults with IGT...
July 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28726299/managing-diabetes-in-preschool-children
#10
Frida Sundberg, Katharine Barnard, Allison Cato, Carine de Beaufort, Linda A DiMeglio, Greg Dooley, Tamara Hershey, Jeff Hitchcock, Vandana Jain, Jill Weissberg-Benchell, Birgit Rami-Merhar, Carmel E Smart, Ragnar Hanas
No abstract text is available yet for this article.
July 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28707353/increasing-ica512-autoantibody-titers-predict-development-of-abnormal-oral-glucose-tolerance-tests
#11
Srinath Sanda
OBJECTIVE: Determine if autoantibody titer magnitude and variability predict glucose abnormalities in subjects at risk for type 1 diabetes. RESEARCH DESIGNS AND METHODS: Demographic information, longitudinal autoantibody titers, and oral glucose tolerance test (OGTT) data were obtained from the TrialNet Pathway to Prevention study. Subjects (first and second degree relatives of individuals with type 1 diabetes) with at least 2 diabetes autoantibodies were selected for analysis...
July 14, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28695611/prediction-of-type-1-diabetes-using-a-genetic-risk-model-in-the-diabetes-autoimmunity-study-in-the-young
#12
Brigitte I Frohnert, Michael Laimighofer, Jan Krumsiek, Fabian J Theis, Christiane Winkler, Jill M Norris, Anette-Gabriele Ziegler, Marian J Rewers, Andrea K Steck
BACKGROUND: Genetic predisposition for type 1 diabetes (T1D) is largely determined by human leukocyte antigen (HLA) genes; however, over 50 other genetic regions confer susceptibility. We evaluated a previously reported 10-factor weighted model derived from the Type 1 Diabetes Genetics Consortium to predict the development of diabetes in the Diabetes Autoimmunity Study in the Young (DAISY) prospective cohort. Performance of the model, derived from individuals with first-degree relatives (FDR) with T1D, was evaluated in DAISY general population (GP) participants as well as FDR subjects...
July 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28664634/comparable-glycemic-outcomes-for-pediatric-type-1-diabetes-patients-in-metropolitan-and-non-metropolitan-regions-of-western-australia-a-population-based-study
#13
Kiranjit K Joshi, Aveni Haynes, Grant Smith, Timothy W Jones, Elizabeth A Davis
BACKGROUND: Pediatric patients diagnosed with type 1 diabetes (T1D) in Western Australia (WA) are managed by a single, specialist multidisciplinary diabetes service based at a central tertiary hospital in the capital city, Perth, which provides outreach care in regional centers. OBJECTIVE: To investigate the hypothesis that outcomes for a contemporary, population-based pediatric T1D cohort, managed by a single tertiary service are similar for metropolitan and non-metropolitan patients using this model of care...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28664624/adherence-to-a-lifestyle-program-for-youth-with-type-2-diabetes-and-its-association-with-treatment-outcome-in-the-today-clinical-trial
#14
Robert I Berkowitz, Marsha D Marcus, Barbara J Anderson, Linda Delahanty, Nisha Grover, Andrea Kriska, Lori Laffel, Amy Syme, Elizabeth Venditti, Dorothy J Van Buren, Denise E Wilfley, Patrice Yasuda, Kathryn Hirst
OBJECTIVE: To assess the association of proxies of behavioral adherence to the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) lifestyle program with changes in glycemic control and obesity in a multi-ethnic sample of youth with type 2 diabetes. METHODS: The TODAY clinical trial included an intensive lifestyle intervention to promote weight reduction. Adherence was assessed with measures of attendance at intervention sessions and rates of self-monitoring of diet and physical activity by participants and their caregivers...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28664608/intima-media-thickness-at-different-arterial-segments-in-pediatric-type-1-diabetes-patients-and-its-relationship-with-advanced-glycation-end-products
#15
Christian Lilje, Julie C Cronan, Elridge J Schwartzenburg, Elizabeth M Owers, Patrice Clesi, Ricardo Gomez, Sarah Stender, James Hempe, Stuart A Chalew, Jeffrey P Cardinale
BACKGROUND: Patients with type 1 diabetes mellitus (T1DM) are at risk for premature atherosclerosis (AS), which has its origin in childhood. Carotid intima-media thickness (IMT) is an established surrogate marker for subclinical AS in adults. The first macroscopically detectable AS changes, however, begin in the abdominal aorta. Advanced glycation end products (AGE) predict microvascular complications in diabetes. OBJECTIVES: To assess the sensitivity for early macrovascular changes of brachial, femoral, and aortic IMT compared to conventional carotid IMT in pediatric T1DM patients ; and the relationship of IMT with AGE...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28664602/neurod1-deficient-diabetes-mody6-identification-of-the-first-cases-in-japanese-and-the-clinical-features
#16
Yukio Horikawa, Mayumi Enya, Hiroyo Mabe, Megumi Fukushima, Noriyuki Takubo, Masaaki Ohashi, Fuki Ikeda, Ken-Ichi Hashimoto, Hirotaka Watada, Jun Takeda
AIMS: Only a few families with neuronal differentiation 1 (NEUROD1)-deficient diabetes, currently designated as maturity-onset diabetes of the young 6 (MODY6), have been reported, but mostly in Caucasian, and no mutation has been identified by family-based screening in Japanese. Accordingly, the phenotypic details of the disease remain to be elucidated. METHODS: We examined a total of 275 subjects having diabetes suspected to be MODY who were negative for mutations in MODY1-5 referred from 155 medical institutions throughout Japan...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28664545/adherence-to-a-pediatric-diabetic-ketoacidosis-protocol-in-children-presenting-to-a-tertiary-care-hospital
#17
Rebecca Ronsley, Nazrul Islam, Claire Ronsley, Daniel L Metzger, Constadina Panagiotopoulos
OBJECTIVE: To review adherence to a provincial diabetic ketoacidosis (DKA) protocol and to assess factors associated with intravenous fluid administration and the length time on an insulin infusion. METHODS: A retrospective chart review was conducted of all DKA admissions to British Columbia Children's Hospital (BCCH) during September 2008 to December 2013. Data collection included diabetes history, estimation of dehydration, insulin and fluid infusion rates, and frequency of laboratory investigations...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28656656/the-dawn-of-automated-insulin-delivery-a-new-clinical-framework-to-conceptualize-insulin-administration
#18
Laurel H Messer, Gregory P Forlenza, R Paul Wadwa, Stuart A Weinzimer, Jennifer L Sherr, Korey K Hood, Bruce A Buckingham, Robert H Slover, David M Maahs
No abstract text is available yet for this article.
June 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28626972/nirca-an-artificial-neural-network-based-insulin-resistance-calculator
#19
Konrad Stawiski, Iwona Pietrzak, Wojciech Młynarski, Wojciech Fendler, Agnieszka Szadkowska
BACKGROUND: Direct measurement of insulin sensitivity in children with type 1 diabetes is cumbersome and time consuming. OBJECTIVE: The aim of our study was to develop novel, accurate machine learning-based methods of insulin resistance estimation in children with type 1 diabetes. METHODS: A hyperinsulinemic hyperglycemic clamp study was performed to evaluate the glucose disposal rate (GDR) in a study group consisting of 315 patients aged 7...
June 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28626942/effect-of-obesity-and-type-2-diabetes-and-glucose-ingestion-on-circulating-spexin-concentration-in-adolescents
#20
S Konnar Hodges, April M Teague, Paul S Dasari, Kevin R Short
Spexin is a novel peptide that has been reported to be down regulated in obese adults and children and in normoglycemic adults following glucose ingestion. Spexin may therefore have a role in metabolic regulation. The purpose of the current study was to determine the effect of obesity and type 2 diabetes (T2DM), and the effect of glucose ingestion on circulating spexin concentration in adolescents. Boys and girls (mean age 16 years old) classified as healthy normal weight (NW, n = 22), obese (Ob, n = 10), or obese with T2DM (n = 12) completed measurements of body composition, blood pressure, cardiorespiratory fitness, and blood concentrations of glucose, insulin, and lipids...
June 19, 2017: Pediatric Diabetes
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