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Pediatric Diabetes

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https://www.readbyqxmd.com/read/28493411/insulinaemia-and-insulin-resistance-in-caucasian-general-paediatric-population-aged-2-to-10-years-associated-risk-factors
#1
Irene Alías-Hernández, Rafael Galera-Martínez, Emilio García-García, Francisco Javier Muñoz-Vico, María Ángeles Vázquez Lopez, María Carmen Olvera-Porcel, Antonio Bonillo Perales
BACKGROUND: The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors. MATERIALS AND METHODS: Population-based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2...
May 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28493372/glycosuria-and-hyperglycemia-in-the-neonatal-period-as-the-first-clinical-sign-of-fanconi-bickel-syndrome
#2
María Pilar Bahíllo-Curieses, Rebeca Garrote-Molpeceres, María Miñambres-Rodríguez, M Rosa Del Real-Llorente, Cristina Tobar-Mideros, Sara Rellán-Rodríguez
Fanconi-Bickel syndrome is a rare inherited disease characterized by the combination of hepatorenal glycogen accumulation, proximal renal tubular dysfunction and impaired utilization of glucose and galactose. The first symptoms of the disorder are recognized in late infancy as clinical characteristics appear. Therapeutic approach is mainly conservative with supplements of calcium, phosphate and vitamin D and small frequent feedings to avoid hypoglycemia. We report 1 clinical case of very early diagnosis, a 19 days old baby girl, in which the first clinical sign of the disease was the detection of glycosuria and vomits...
May 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28488397/dietary-sodium-intake-relates-to-vascular-health-in-children-with-type-1-diabetes
#3
Jemma Anderson, Jennifer J Couper, Sarah Toome, Christine Mpundu-Kaambwa, Lynne C Giles, Roger Gent, Brian Coppin, Alexia S Peña
BACKGROUND AND OBJECTIVE: Children with type 1 diabetes (T1D) have vascular dysfunction and frequently struggle to adhere to dietary recommendations. Limited data exist for the vascular consequences of poor diet quality in children. We aimed to evaluate the association between dietary components and vascular function in children with T1D. METHODS: Cross-sectional study including 90 children (13.6 [3.5] years, 41 boys) with T1D. They had evaluation of dietary micro and macronutrients (Australian Child and Adolescent Eating Survey), vascular endothelial and smooth muscle function (flow-mediated dilatation and glyceryl trinitrate mediated dilatation [GTN], respectively), clinical and biochemical variables...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28488346/predictors-of-glycemic-control-in-the-first-year-of-diagnosis-of-childhood-onset-type-1-diabetes-a-systematic-review-of-quantitative-evidence
#4
REVIEW
Veena Mazarello Paes, Dimitrios Charalampopoulos, Julie Edge, David Taylor-Robinson, Terence Stephenson, Rakesh Amin
Early glycemic control is associated with reduced future vascular complications risk in type 1 diabetes (T1D). The aim of this study was to systematically review evidence on the predictors of glycemic control within 12 months of diagnosis of childhood onset T1D. Inclusion criteria for the electronic search were: interventional and observational studies that assessed and quantified an association between the predictor and glycemic control within 12 months of diagnosis of childhood onset T1D. A total of 17 915 articles were identified from 6 databases and 20 studies were finally included in the analysis...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28488272/pathophysiological-characteristics-of-preproinsulin-specific-cd8-t-cells-in-subjects-with-juvenile-onset-and-adult-onset-type-1-diabetes-a-1-year-follow-up-study
#5
Mahinder Paul, Darshan Badal, Neenu Jacob, Devi Dayal, Rakesh Kumar, Anil Bhansali, Sanjay Kumar Bhadada, Naresh Sachdeva
AIMS/HYPOTHESIS: Among the beta-cell associated antigens, preproinsulin (PPI) has been shown to play a key role in the pathogenesis of type 1 diabetes (T1D). PPI-specific autoreactive CD8+ T cells emerge early during beta-cell destruction and persist in peripheral circulation during diabetes progression. However, the influence of insulin therapy on phenotype of autoreactive CD8+ T cells in T1D including, juvenile-onset T1D (JOT1D), and adult-onset T1D (AOT1D) is not yet known. METHODS: We followed the time course of PPI-specific CD8+ T cells in JOT1D and AOT1D subjects that achieved glycemic control after 1 year of insulin therapy, using major histocompatibility complex-I (MHC-I) dextramers by flow cytometry...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28436179/monogenic-diabetes-prevalence-among-polish-children-summary-of-11%C3%A2-years-long-nationwide-genetic-screening-program
#6
Beata Małachowska, Maciej Borowiec, Karolina Antosik, Arkadiusz Michalak, Anna Baranowska-Jaźwiecka, Grażyna Deja, Przemysława Jarosz-Chobot, Agnieszka Brandt, Małgorzata Myśliwiec, Małgorzata Stelmach, Joanna Nazim, Jadwiga Peczyńska, Barbara Głowińska-Olszewska, Anita Horodnicka-Józwa, Mieczysław Walczak, Maciej T Małecki, Agnieszka Zmysłowska, Agnieszka Szadkowska, Wojciech Fendler, Wojciech Młynarski
BACKGROUND: Estimated monogenic diabetes (MD) prevalence increases as screening programs proceeds. OBJECTIVE: To estimate prevalence of MD among Polish children. SUBJECTS: Patients and their family members suspected of suffering from MD (defined as causative mutation in one of the Maturity Onset Diabetes of the Young or permanent neonatal diabetes mellitus genes) were recruited between January 2005 and December 2015. METHODS: Nationwide prevalence was estimated based on data from 6 administrative provinces (out of 16 in Poland) with high referral rates of patients (>10 per 100 000 children)...
April 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28436135/psychiatric-medication-use-before-and-after-the-onset-of-type-1-diabetes-in-children-and-adolescents-a-population-based-cohort-study
#7
Soulmaz Fazeli Farsani, Heshu Abdullah-Koolmees, Patrick C Souverein, Anthonius de Boer, Aukje K Mantel-Teeuwisse
BACKGROUND: Several studies showed a bidirectional association between type 2 diabetes and psychiatric disorders in adults. Because there is limited information on the association between type 1 diabetes (T1D) and psychiatric disorders (including psychiatric medication use) in children and adolescents, we assessed frequency of use of these medications before and after the onset of T1D. METHODS: A population-based cohort study was conducted in the Dutch PHARMO Record Linkage System (1999-2009)...
April 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28429581/nighttime-is-the-worst-time-parental-fear-of-hypoglycemia-in-young-children-with-type-1-diabetes
#8
Michelle A Van Name, Marisa E Hilliard, Claire T Boyle, Kellee M Miller, Daniel J DeSalvo, Barbara J Anderson, Lori M Laffel, Stephanie E Woerner, Linda A DiMeglio, William V Tamborlane
BACKGROUND: Fear of hypoglycemia is common in parents of young children with type 1 diabetes (T1D), but little is known about the specific fears that parents most often experience. Hypoglycemia fear has been associated with poorer glycemic control in older children, though not yet studied in a large cohort of very young children. MATERIALS AND METHODS: Parents of 549 children <7 years (mean 5.2 ± 1.2 years [19% <3 years]) with a mean diabetes duration of 2...
April 21, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28425183/associations-between-major-life-events-and-adherence-glycemic-control-and-psychosocial-characteristics-in-teens-with-type-1-diabetes
#9
Persis V Commissariat, Lisa K Volkening, Zijing Guo, Jessica L ElBach, Deborah A Butler, Lori M Laffel
AIMS: This cross-sectional study assessed the type of major life events occurring in a contemporary sample of teens with type 1 diabetes and the association between event frequency and demographic, diabetes management, and psychosocial characteristics. METHODS: Parents of 178 teens completed the Life Events Checklist to report major events teens had experienced in the last year: 42% experienced 0 to 1 event (n = 75), 32% experienced 2 to 3 events (n = 57), and 26% experienced 4+ events (n = 46)...
April 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28419661/cognitive-behavioural-therapy-stabilises-glycaemic-control-in-adolescents-with-type-1-diabetes-outcomes-from-a-randomised-control-trial
#10
Christina Wei, Ruth J Allen, Patricia M Tallis, Fiona J Ryan, Linda P Hunt, Julian Ph Shield, Elizabeth C Crowne
BACKGROUND: To compare the impact of cognitive behavioural therapy (CBT) with non-directive supportive counselling (NDC) on glycaemic control and psychological well-being in adolescents with type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: Participants aged 11 to 16 years with T1DM (duration ≥1 year) from 4 UK-based paediatric diabetes centres were randomised to receive either 6 weekly sessions of 1-to-1 CBT (n = 43) or NDC (n = 42), with 2 further sessions at 6 and 12 months...
April 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28401628/metabolomics-reveals-new-metabolic-perturbations-in-children-with-type-1-diabetes
#11
Alfonso Galderisi, Paola Pirillo, Vittoria Moret, Matteo Stocchero, Antonina Gucciardi, Giorgio Perilongo, Carlo Moretti, Carlamaria Monciotti, Giuseppe Giordano, Eugenio Baraldi
OBJECTIVE: Using an untargeted metabolomics approach we investigated the metabolome of children with type 1 diabetes (T1D) in comparison with healthy peers and explored the contribution of HbA1c and clinical features to the observed difference. RESEARCH DESIGN AND METHODS: We enrolled children with T1D aged 6-15 years, attending the pediatric diabetes clinic of University of Padova (Italy). Healthy controls were enrolled on voluntary basis and matched for age, sex, pubertal status, body mass index (BMI)...
April 12, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28401620/atp4a-autoimmunity-in-pediatric-patients-with-type-1-diabetes-and-its-relationship-to-blood-count-iron-metabolism-and-vitamin-b12
#12
Agata Chobot, Ewa Rusak, Janet Wenzlau, Howard Davidson, Piotr Adamczyk, Agnieszka Krzywicka, Bogdan Mazur, Joanna Polańska, Marian Rewers
OBJECTIVE: We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. SUBJECTS: The study included 94 (59% female) T1D children (aged 12.5 ± 4.1 years, T1D duration 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol) with no other autoimmune diseases...
April 12, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28397413/endocrine-and-metabolic-consequences-due-to-restrictive-carbohydrate-diets-in-children-with-type-1-diabetes-an-illustrative-case-series
#13
Martin de Bock, Kristine Lobley, Donald Anderson, Elizabeth Davis, Kim Donaghue, Marcelle Pappas, Aris Siafarikas, Yoon Hi Cho, Timothy Jones, Carmel Smart
Low carbohydrate diets for the management of type 1 diabetes have been popularised by social media. The promotion of a low carbohydrate diet in lay media is in contrast to published pediatric diabetes guidelines that endorse a balanced diet from a variety of foods for optimal growth and development in children with type 1 diabetes. This can be a source of conflict in clinical practice. We describe a series of 6 cases where adoption of a low carbohydrate diet in children impacted growth and cardiovascular risk factors with potential long-term sequelae...
April 11, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28378429/impact-of-lifestyle-behavior-change-on-glycemic-control-in-youth-with-type-2-diabetes
#14
Andrea Kriska, Laure El Ghormli, Kenneth C Copeland, Janine Higgins, Carolyn E Ievers-Landis, Lorraine E Levitt Katz, Paula M Trief, Aimee D Wauters, Patrice M Yasuda, Linda M Delahanty
BACKGROUND: Little is known about the feasibility and impact of lifestyle intervention, determined by change in diet and cardiovascular fitness (CRF), on glycemic control in youth who are overweight with type 2 diabetes. This was examined in the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial cohort from across 15 US centers. SUBJECTS: TODAY enrolled 699 youth aged 10 to 17 years with type 2 diabetes <2 years and body mass index ≥85th percentile at baseline...
April 4, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28370959/therapeutic-plasma-exchange-normalizes-insulin-mediated-response-in-a-child-with-type-1-diabetes-and-insulin-autoimmune-syndrome
#15
Erin F Sharwood, Ian P Hughes, Carel J Pretorius, Peter Trnka, Jane Peake, Tony Huynh
BACKGROUND: Insulin autoimmune syndrome (IAS), characterized by glycemic dysregulation and life-threatening hypoglycemia, can occur in patients with type 1 diabetes (T1D). Diagnostic confirmation is complex but important in order to ensure timely initiation of definitive therapy. AIMS: We aimed to quantitate the degree of immunoglobulin-insulin complex (IIC) formation and its effects on glycemic control in a patient with T1D and IAS compared with T1D and non-T1D controls and before and after therapeutic plasma exchange (TPE)...
March 29, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28326652/paediatric-type-2-diabetes-in-china-pandemic-progression-and-potential-solutions
#16
REVIEW
Qing Ye, Jun-Fen Fu
China is gradually taking its place as one of the world's economic giants and concurrently learning to cope with the burden of diseases that are more common in the developed world, such as paediatric type 2 diabetes mellitus. The prevalence of type 2 diabetes has been recently observed among children and adolescents in China; hence, there is a lack of information about the incidence, prevalence, pathogenesis, and pathophysiology of the disease. Diagnosis, treatment, and management have been standardized to a large degree, but there is still a need for data regarding optimal management protocols and how to achieve the best control over current state of the disease...
March 22, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28318073/self-and-parent-reported-executive-problems-in-adolescents-with-type-1-diabetes-are-associated-with-poor-metabolic-control-and-low-physical-activity
#17
Charlotte Nylander, Ylva Tindberg, Josephine Haas, Ingemar Swenne, Torun Torbjörnsdotter, Karin Åkesson, Eva Örtqvist, Jan Gustafsson, Elisabeth Fernell
BACKGROUND: Management of diabetes is demanding and requires efficient cognitive skills, especially in the domain of executive functioning. However, the impact of impaired executive functions on diabetes control has been studied to a limited extent. The aim of the study is to investigate the association between executive problems and diabetes control in adolescents with type 1 diabetes. MATERIALS AND METHODS: Two hundred and forty-one of 477 (51%) of 12- to 18-year-old adolescents, with a diabetes duration of >2 years in Stockholm, Uppsala, and Jönköping participated...
March 20, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28303678/schooling-diabetes-use-of-continuous-glucose-monitoring-and-remote-monitors-in-the-home-and-school-settings
#18
Christine Erie, Michelle A Van Name, Kate Weyman, Stuart A Weinzimer, Jennifer Finnegan, Kristin Sikes, William V Tamborlane, Jennifer L Sherr
BACKGROUND: Despite significant advances in type 1 diabetes (T1D) management, achieving targeted glycemic control in pediatric patients remains a struggle. Continuous glucose monitoring (CGM) with remote access holds the promise to address this challenge by allowing caregivers to monitor glucose, even when the child is not directly under their supervision. OBJECTIVE: To explore real-time and remote CGM practices in homes and schools, including caregiver expectations regarding this technology...
March 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28271591/a-novel-heterozygous-mutation-of-the-wfs1-gene-leading-to-constitutive-endoplasmic-reticulum-stress-is-the-cause-of-wolfram-syndrome
#19
Shuntaro Morikawa, Toshihiro Tajima, Akie Nakamura, Katsura Ishizu, Tadashi Ariga
BACKGROUND: Wolfram syndrome (WS) is a disorder characterized by the association of insulin-dependent diabetes mellitus (DM), diabetes insipidus, deafness, and optic nerve atrophy. WS is caused by WFS1 mutations encoding WFS1 protein expressed in endoplasmic reticulum (ER). During ER protein synthesis, misfolded and unfolded proteins accumulate, known as "ER stress". This is attenuated by the unfolded protein response (UPR), which recovers and maintains ER functions. Because WFS1 is a UPR component, mutant WFS1 might cause unresolvable ER stress conditions and cell apoptosis, the major causes underlying WS symptoms...
March 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28271589/clustering-of-cardio-metabolic-risk-factors-in-parents-of-adolescents-with-type-1-diabetes-and-microalbuminuria
#20
M Loredana Marcovecchio, Päivi H Tossavainen, Katharine Owen, Catherine Fullah, Paul Benitez-Aguirre, Stefano Masi, Ken Ong, Helen Nguyen, Scott T Chiesa, R Neil Dalton, John Deanfield, David B Dunger
OBJECTIVE: To evaluate the association between a clustering of cardio-metabolic risk factors in parents and the development of microalbuminuria (MA) in their offspring with childhood-onset type 1 diabetes (T1D). METHODS: The study population comprised 53 parents (mean age [±SD]: 56.7±6.2 years) of 35 T1D young people with MA (MA+) and 86 parents (age: 56.1±6.3 years) of 50 matched offspring with normoalbuminuria (MA-), who underwent clinical, biochemical and cardiovascular imaging assessments...
March 8, 2017: Pediatric Diabetes
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