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Pediatric Dermatology

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https://www.readbyqxmd.com/read/29143366/patch-testing-in-israeli-children-with-suspected-allergic-contact-dermatitis-a-retrospective-study-and-literature-review
#1
Yaron Zafrir, Akiva Trattner, Emmillia Hodak, Oren Eldar, Moshe Lapidoth, Dan Ben Amitai
BACKGROUND/OBJECTIVES: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature. METHODS: The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11...
November 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29143471/ethnic-differences-in-stratum-corneum-functions-between-chinese-and-thai-infants-residing-in-bangkok-thailand
#2
Tsutomu Fujimura, Yuki Miyauchi, Kyoko Shima, Mitsuyuki Hotta, Hisashi Tsujimura, Takashi Kitahara, Yoshinori Takema, Pakhawadee Palungwachira, Diane Laohathai, Jetchawa Chanthothai, Thamthiwat Nararatwanchai
BACKGROUND/OBJECTIVES: Ethnic and racial differences in infant skin have not been well characterized. The purpose of this study was to establish whether there are ethnic differences and similarities in the stratum corneum (SC) functions of Thai and Chinese infants. METHODS: Healthy infants 6 to 24 months of age (N = 60; 30 Thai, 30 Chinese) who resided in Bangkok, Thailand, were enrolled. Transepidermal water loss (TEWL) and SC hydration (capacitance) on the thigh, buttock, and upper arm were measured...
November 15, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29120075/ultrasound-findings-in-idiopathic-facial-aseptic-granuloma-case-series-and-literature-review
#3
Nicole Knöpfel, Alba Gómez-Zubiaur, Lucero Noguera-Morel, Antonio Torrelo, Angela Hernandez-Martin
Idiopathic facial aseptic granuloma is an inflammatory nodule commonly located on the cheeks and eyelids in young children. Despite its prolonged course, it tends toward spontaneous resolution, so invasive diagnostic procedures should be avoided. Cutaneous ultrasound is a noninvasive modality that has been found to improve the diagnostic accuracy of nodular skin lesions. We report five children with idiopathic facial aseptic granuloma in whom high-resolution ultrasound examination provided distinctive findings...
November 9, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29120072/rasa1-mutation-in-a-family-with-capillary-malformation-arteriovenous-malformation-syndrome-a-discussion-of-the-differential-diagnosis
#4
Lisa R Edwards, Adam B Blechman, Barrett J Zlotoff
We describe a family who presented with several scattered, vascular, cutaneous lesions and was found to have a novel mutation in RASA1, diagnostic of capillary malformation-arteriovenous malformation syndrome. Our patient was initially given a presumptive clinical diagnosis of hereditary hemorrhagic telangiectasia. Capillary malformation-arteriovenous malformation syndrome shares several features with hereditary hemorrhagic telangiectasia and hereditary benign telangiectasia, but it can be distinguished clinically according to its morphologic appearance and distribution of cutaneous vascular lesions, the presence of internal fast-flow lesions, and genetic analysis...
November 9, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29119592/orthopedic-complications-of-linear-morphea-implications-for-early-interdisciplinary-care
#5
REVIEW
Jennifer J Schoch, Bradley S Schoch, Jean David Werthel, Amy L McIntosh, Dawn M R Davis
Linear morphea of the limb primarily affects children, and extracutaneous manifestations are common. Orthopedic surgeons are often essential in the care of patients with linear morphea, yet there are few reports outlining specific orthopedic complications in this population. We sought to improve the understanding of orthopedic complications in linear morphea of the limb. Between 1999 and 2014, 51 children were evaluated for linear morphea of an extremity. Twenty-six (51%) had documented orthopedic manifestations...
November 9, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29110325/a-case-of-segmental-stiff-skin-syndrome-treated-with-systemic-losartan
#6
Nicole Maillet-Lebel, Victor Kokta, Jerome Coulombe, Julie Powell
Stiff skin syndrome (SSS) is a rare, autosomal dominant cutaneous disorder with progressive, symmetric, sclerotic skin changes of the shoulders, hips, and thighs. In a recent publication, a distinct segmental variant of SSS was proposed. In this report we discuss the case of a boy with segmental SSS and review the current literature.
November 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29105836/pediatric-severity-of-alopecia-tool
#7
Elena Bernardis, Jonathan Nukpezah, Ping Li, Theresa Christensen, Leslie Castelo-Soccio
The Severity of Alopecia Tool serves as a tool for alopecia research and a clinical guideline for following progression of disease. The original Severity of Alopecia Tool score does not take into account pediatric age groups. As new clinical trials for alopecia areata include more children, a more accurate tool should be available for this population. By collecting images from patients 2-21 years of age and aligning the hair-bearing regions of the scalp, we created an adaptation of the Severity of Alopecia Tool for scoring hair loss percentage of the top, parietal, and occipital scalp in individuals 2-5, 6-11, and 12-21 years of age...
November 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29105824/wound-culture-isolated-antibiograms-and-caregiver-reported-skin-care-practices-in-children-with-epidermolysis-bullosa
#8
Hannah M Singer, Laura E Levin, Maria C Garzon, Christine T Lauren, Paul J Planet, Nicole W Kittler, Susan Whittier, Kimberly D Morel
BACKGROUND/OBJECTIVES: Many patients with epidermolysis bullosa (EB) require intensive daily wound care and individualized treatment plans. Understanding patient's home skin care routines and emerging antibiotic resistance patterns in EB wounds is necessary to optimize treatment recommendations. The objective was to identify patterns of antimicrobial resistance in EB wounds and characterize patient's home practices of skin care and bathing. METHODS: This was an observational study of 23 children with EB at an outpatient pediatric dermatology practice in New York City from 2012 to 2014...
November 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044698/methotrexate-treatment-in-a-case-of-juvenile-pityriasis-rubra-pilaris
#9
Anne H Boyd, Ingrid C Polcari
An 8-year-old boy who was initially diagnosed with plaque psoriasis failed management with topical therapies and skin biopsy confirmed the suspected diagnosis of juvenile pityriasis rubra pilaris (PRP). Pityriasis rubra pilaris is a rare inflammatory disorder of the skin characterized by follicular keratotic papules coalescing into plaques, along with palmoplantar keratoderma. Treatment modalities include topical and systemic therapies, although previous studies have not shown much benefit with methotrexate in children...
October 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044633/extensive-nail-changes-in-a-toddler-with-multisystemic-langerhans-cell-histiocytosis
#10
Vimal Kumar, Dhanalakshmi Angappan, Julius Scott, Deenadayalan Munirathnam, Mukul Vij, Naresh Shanmugam
Langerhans cell histiocytosis (LCH) is a multisystem disorder involving various organs. Nail changes in LCH are extremely rare. We present this case report of extensive nail changes in an 18-month-old child with multisystem LCH.
October 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044722/alopecic-and-aseptic-nodule-of-the-scalp-in-a-girl
#11
Erika Rodríguez-Lobato, Daniel Morgado-Carrasco, Priscila Giavedoni, Juan Ferrando
Alopecic and aseptic nodule of the scalp is a rare entity characterized by the presence of nodules or cysts with sterile punctured material and negative cultures accompanied by nonscarring alopecia in the scalp of young men. We describe a case in which an 11-year-old girl presented with a nodular, fluctuant, round lesion on the vertex with localized alopecia. High-resolution ultrasound showed a hypoechoic lesion with increased flow on Doppler imaging and culture of the citrine-yellowish material obtained by puncture was negative...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044700/epidermal-nevus-syndromes-new-insights-into-whorls-and-swirls
#12
REVIEW
Sarah Asch, Jeffrey L Sugarman
Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus comedonicus, congenital hemidysplasia with ichthyosiform nevus and limb defects syndrome, phakomatosis pigmentokeratotica, Becker's nevus, porokeratotic adnexal ostial nevus, inflammatory linear verrucous epidermal nevi, and cutaneous-skeletal hypophosphatemia syndrome...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29044644/hermansky-pudlak-syndrome-report-of-two-patients-with-updated-genetic-classification-and-management-recommendations
#13
REVIEW
Manuela Loredana Asztalos, Kristian T Schafernak, Jayla Gray, Adam Berry, Amy S Paller, Anthony J Mancini
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder caused by mutations in one of nine genes involved in the packaging and formation of specialized lysosomes, including melanosomes and platelet-dense granules. The cardinal features are pigmentary dilution, bleeding diathesis, and accumulation of ceroid-like material in reticuloendothelial cells. Pulmonary fibrosis induced by tissue damage is seen in the most severe forms, and one subtype is characterized by immunodeficiency. We describe two patients with HPS type 1 and review the updated gene-based classification, clinical features, and recommendations for evaluation and follow-up...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29034507/screening-for-sturge-weber-syndrome-a-state-of-the-art-review
#14
REVIEW
Michaela Zallmann, Richard J Leventer, Mark T Mackay, Michael Ditchfield, Philip S Bekhor, John C Su
Infants with a high-risk distribution of port-wine stains are commonly screened for Sturge-Weber syndrome using brain magnetic resonance imaging. There is no consensus about which port-wine stain phenotypes to screen, optimal timing, screening sensitivity, or whether presymptomatic diagnosis improves neurodevelopmental outcomes. This state-of-the-art review examines the evidence in favor of screening for Sturge-Weber syndrome, based on its effect on neurodevelopmental outcomes, against the risks and limitations of screening magnetic resonance imaging and electroencephalography...
October 16, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29024079/the-preadolescent-acne-microbiome-a-prospective-randomized-pilot-study-investigating-characterization-and-effects-of-acne-therapy
#15
Carrie C Coughlin, Shane M Swink, Joseph Horwinski, Georgia Sfyroera, Julia Bugayev, Elizabeth A Grice, Albert C Yan
BACKGROUND/OBJECTIVES: Acne, a common pediatric disease, tends to be more comedonal in preadolescents, whereas older individuals are more likely to have inflammatory lesions in addition to comedones. Thus the microbiome of preadolescents may be different. In this pilot study we aimed to characterize the preadolescent acne microbiome, compare the microbiome in preadolescents with and without acne, and investigate changes in the microbiome after topical treatment with benzoyl peroxide or a retinoid in a small cohort of preadolescents...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023993/pediatric-keloids-a-6-year-retrospective-review
#16
Afieharo I Michael, Samuel A Ademola, Olayinka A Olawoye, Ayodele O Iyun, Wasiu Adebayo, Odunayo M Oluwatosin
BACKGROUND/OBJECTIVES: Keloids are reportedly rare at the extremes of life. We sought to describe the epidemiology of pediatric keloids seen at the plastic surgery outpatient department of the University College Hospital, Ibadan. METHODS: We retrospectively reviewed all children younger than 19 years who presented with nonburn keloids between 2008 and 2014. Data were obtained on age; duration, size, and location of the keloid; family history; mode of treatment; and outcome...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023980/agminated-segmental-plaque-type-blue-nevus-associated-with-hypertrichosis-and-soft-tissue-hypertrophy-report-of-a-case-and-review-of-the-literature
#17
Manrup K Hunjan, Desiree Mohandas, Alina G Bridges, Megha Tollefson
Blue nevi are common skin neoplasms that typically present as asymptomatic solitary papules, although they may rarely occur in an agminated configuration. We describe a case of agminated blue nevus in a segmental facial distribution associated with soft tissue hypertrophy and hypertrichosis in a 16-year-old boy and present a review of the literature. Although they are generally considered to be benign, concurrent soft tissue changes occurring within an agminated blue nevus should be investigated thoroughly to exclude alternate diagnoses...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023894/perineal-groove-in-female-infants-a-case-series-and-literature-review
#18
Maria Garcia-Palacios, Roberto Mendez-Gallart, Jorge Cortizo-Vazquez, Pablo Rodriguez-Barca, Elina Estevez-Martinez, Adolfo Bautista-Casasnovas
BACKGROUND: Perineal groove is a rare congenital malformation that is unknown to many clinicians and is often misdiagnosed. Although it may be self-resolving during childhood, this nonepithelized mucous membrane can pose the risk of local irritation and infection, particularly urinary tract infection. METHODS: A retrospective study of female infants diagnosed with a perineal groove was performed, demographic characteristics and clinical features were analyzed, and a photographic review was conducted...
October 11, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29023873/juvenile-elastoma-without-germline-mutations-in-lemd3-gene-a-case-of-buschke-ollendorff-syndrome
#19
Alessandra Condorelli, Nicolo Musso, Laura Scuderi, Daniele F Condorelli, Vincenza Barresi, Rocco De Pasquale
We report the case of a 6-year-old Caucasian girl with clinical and histopathologic features of Buschke-Ollendorff syndrome. Histologic examination of skin lesions showed thick, curly, elastic fibers in the derma. Bone lesions compatible with Buschke-Ollendorff syndrome were found in the girl's mother. Mutations in LEMD3 are pathogenic for Buschke-Ollendorff syndrome. Analysis of all exons and exon-intron junctions of LEMD3 did not reveal any germline mutations.
October 10, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28967681/ranitidine-induced-black-tongue-a-case-report
#20
Meltem Akcaboy, Sanliay Sahin, Pelin Zorlu, Saliha Şenel
Black tongue is a rare, benign, self-limiting disorder caused by certain conditions and some medications. We report the first case of a child diagnosed with black tongue associated with ranitidine use. We report our case to emphasize the rare side effect of this frequently used drug. Health care professionals should be aware of the likelihood of ranitidine-induced black tongue in clinical practice.
October 2, 2017: Pediatric Dermatology
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