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Pediatric Dermatology

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https://www.readbyqxmd.com/read/29790593/efficacy-and-absorption-of-topical-sirolimus-for-the-treatment-of-vascular-anomalies-in-children-a-case-series
#1
Sophie Le Sage, Michèle David, Josée Dubois, Julie Powell, Catherine C McCuaig, Yves Théorêt, Niina Kleiber
BACKGROUND/OBJECTIVES: Efficacy of topical sirolimus has recently been described in lymphatic anomalies but not in other types of vascular anomalies. To our knowledge, systemic absorption of topical sirolimus in these lesions has not yet been reported. The objective was to evaluate the efficacy, tolerance, and absorption of topical sirolimus 0.1% with different types of vascular anomalies in children. METHODS: Sirolimus 0.1% was applied on cutaneous vascular anomalies in six children aged 2-17...
May 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29790187/eosinophilic-annular-erythema-treated-with-dupilumab
#2
Samantha C Gordon, Sarah N Robinson, Minawaer Abudu, Michelle Her, Sandyha Deverapalli, Adrianne Levin, Birgitta A R Schmidt, Stephen E Gellis, David Rosmarin
Eosinophilic annular erythema is a rare, benign, recurrent condition characterized by annular skin lesions, tissue eosinophilia, and resistance to a variety of treatments. There are fewer than 30 cases reported in the English literature, 7 of which are in children. We present a case of recurrent eosinophilic annular erythema in an adolescent that was successfully treated with dupilumab, an interleukin-4 receptor alpha antagonist.
May 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29786146/awareness-of-and-phobias-about-topical-corticosteroids-in-parents-of-infants-with-eczema-in-hangzhou-china
#3
Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng
BACKGROUND/OBJECTIVES: Knowledge of and phobias about topical corticosteroids in parents of infants with eczema affect efficacy of eczema treatment. METHODS: We surveyed 300 parents of children with eczema using a questionnaire to investigate knowledge of and phobias about topical corticosteroids. RESULTS: Overall, 85.7% (n = 257) of children had used topical corticosteroids, with 12.8% (n = 33) of children having steroids applied for only 1-3 days per episode; 79...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29786144/self-initiated-use-of-topical-cannabidiol-oil-for-epidermolysis-bullosa
#4
Malcolm P Chelliah, Zachary Zinn, Phoung Khuu, Joyce M C Teng
Epidermolysis bullosa is a rare blistering skin disorder that is challenging to manage because skin fragility and repeated wound healing cause itching, pain, limited mobility, and recurrent infections. Cannabidiol, an active cannabinoid found in cannabis, is postulated to have antiinflammatory and analgesic effects. We report 3 cases of self-initiated topical cannabidiol use in patients with epidermolysis bullosa in an observational study. One patient was weaned completely off oral opioid analgesics. All 3 reported faster wound healing, less blistering, and amelioration of pain with cannabidiol use...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766561/erythema-nodosum-arising-during-everolimus-therapy-for-tuberous-sclerosis-complex
#5
Eloise R Galligan, Lindsey Fix, Laura E Levin, Lisa Imundo, Darrell J Yamashiro, Maria C Garzon
Indications for everolimus and other drugs within the mammalian target of rapamycin inhibitor class have recently expanded to include tuberous sclerosis complex. Everolimus is generally well tolerated, but it is important for physicians to identify and manage associated cutaneous adverse effects. We report the first case of a child developing erythema nodosum while undergoing everolimus therapy.
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766552/hand-foot-and-mouth-disease-photolocalized-to-sunburn
#6
Morgan Murphrey, Samantha Casselman, Kevin B Yarbrough
Hand, foot, and mouth disease is a common exanthem linked to infection with several non-polio enteroviruses. This case of an 11-year-old boy with an enteroviral infection limited to areas of sunburn is an atypical presentation of hand, foot, and mouth disease. Recognition of this unusual distribution will allow pediatricians and pediatric dermatologists to appropriately manage and counsel patients and parents.
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766548/dermal-non-neural-granular-cell-tumor-in-a-3-year-old-child
#7
Bilaal Kabir, Michele Ramien, Mofeedah Al Shammary, Joseph de Nanassy, Dina El Demellawy
Dermal non-neural granular cell tumors, also known as primitive polypoid granular cell tumors, are a rare group of distinct cutaneous non-neural granular cell tumors. Pediatric cases are rare, and to the best of our knowledge, we report the youngest patient with dermal non-neural granular cell tumors.
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766546/therapeutic-interventions-to-lessen-the-psychosocial-effect-of-vitiligo-in-children-a-review
#8
REVIEW
Simi D Cadmus, Ashley D Lundgren, Ammar M Ahmed
Vitiligo commonly affects children, with half of affected individuals experiencing disease onset before the age of 20. Because childhood is a time of advancement in social and psychological development, understanding the extent of the effect of the disease and means of alleviation is crucial. Vitiligo has been shown to decrease children's quality of life, with greater distress in children with highly visible lesions and darker skin tones. This article reviews the literature regarding interventions that have been analyzed in children...
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766572/multiple-superficial-oral-mucoceles-after-mycoplasma-induced-mucositis
#9
Meggie Morand, Afshin Hatami
Oral mucoceles are lesions arising mainly from the minor salivary glands and are thought to occur after excretory duct trauma. We report a case of multiple superficial oral mucoceles on a child's labial mucosa after Mycoplasma pneumoniae mucositis. Mucoceles can mimic persistent or recurrent stomatitis and lead to potential errors in management.
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766562/cutaneous-fibrolipomatous-hamartoma-report-of-2-cases-with-retrocalcaneal-location
#10
Ana Isabel Rodríguez Bandera, Drew K Saylor, Maria José Beato, Jeffrey North, Ilona J Frieden
Precalcaneal congenital fibrolipomatous hamartoma is an underreported benign entity that has been described in the literature under different names. We present two cases of unilateral fibrolipomatous hamartoma (FLH) appearing in a unique location: on the posterior aspect of the foot overlying the heel. We propose the term "FLH of the skin" as a more inclusive and less confusing term for this condition, thus allowing distinction with FLH arising from neural tissue. High-frequency ultrasonography appears to be a useful diagnostic tool that may avoid unnecessary biopsies for this condition...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766557/risk-factors-for-ocular-complications-in-periocular-infantile-hemangiomas
#11
Liat Samuelov, Michael Kinori, Karen Rychlik, Meghana Konanur, Sarah L Chamlin, Bahram Rahmani, Anthony J Mancini
BACKGROUND/OBJECTIVES: Infantile hemangiomas are the most common benign tumors of childhood. Although some children with periocular infantile hemangiomas do not require treatment, these lesions may result in amblyopia and visual impairment if not properly treated. We have attempted to characterize clinical features of periocular infantile hemangiomas that predict negative ocular outcomes and thus require prompt referral to an ophthalmologist and initiation of therapy. METHODS: This study included children with periocular infantile hemangiomas consecutively seen at Ann & Robert H...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766555/hand-foot-skin-reaction-related-to-use-of-the-multikinase-inhibitor-sorafenib-and-hard-orthotics
#12
Ayan Kusari, Jenna Borok, Allison M Han, Alix Jessika Valderrama, Sheila Fallon Friedlander
Hand-foot-skin reaction is a distinct clinical condition arising in association with the use of multikinase inhibitors, including sorafenib. Because multikinase inhibitors are increasingly being used in children with cancer, recognition of this previously unfamiliar condition is of importance to pediatric dermatologists. We describe the diagnosis and successful treatment of a case of hand-foot-skin reaction in a child taking sorafenib for an unresectable desmoid tumor.
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766554/primary-cutaneous-aspergillosis-at-the-site-of-cyanoacrylate-skin-adhesive-in-a-neonate
#13
Ayan Kusari, Jessica Sprague, Lawrence F Eichenfield, Catalina Matiz, Victoria R Barrio
Primary cutaneous aspergillosis is a rare but potentially life-threatening disease. We present the case of a premature infant who developed primary cutaneous aspergillosis with Aspergillus niger at the site of a skin abrasion that had been treated with a purple-colored cyanoacrylate product. The infection was treated successfully with gentle debridement of the cyanoacrylate product, followed by intravenous voriconazole and topical fluconazole. To our knowledge, this is the first reported case of primary cutaneous aspergillosis occurring at the site of cyanoacrylate-based skin adhesive...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766553/erythema-multiforme-after-orf-virus-infection
#14
Angella López-Cedeño, Gustavo Cañedo, Nicole Knöpfel, Isabel Colmenero, Esperanza Pérez-Pastrana, Antonio Torrelo
The case of a 6-year-old boy with multiple, target-shaped lesions and a crusted nodule on his right index finger is presented. Based on clinical findings and the patient's recent contact with sheep and goats, a diagnosis of orf disease associated with erythema multiforme was suspected. Microscopy studies confirmed the presence of parapoxvirus in the primary lesion. Orf-induced erythema multiforme is a rare complication of orf in children, possibly related to the presence of orf virus DNA in erythema multiforme lesions...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29766551/lower-lip-capillary-malformation-associated-with-lymphatic-malformation-without-overgrowth-part-of-the-spectrum-of-clapo-syndrome
#15
Camila Downey, Juan Carlos López-Gutiérrez, Esther Roé-Crespo, Luis Puig, Eulalia Baselga
Characteristic lower lip capillary malformation of CLAPO syndrome (Capillary malformation of the lower lip, Lymphatic malformations of the face and neck, Asymmetry, and Partial or generalized Overgrowth) may also occur as an isolated lesion or with only minor anomalies, supporting the concept that there is a spectrum of abnormalities in CLAPO syndrome. Preliminary studies have demonstrated mosaic activating mutations in PIK3CA.
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29722071/texting-atopic-dermatitis-patients-to-optimize-learning-and-eczema-area-and-severity-index-scores-a-pilot-randomized-control-trial
#16
Hannah M Singer, Laura E Levin, Kimberly D Morel, Maria C Garzon, Melissa S Stockwell, Christine T Lauren
BACKGROUND/OBJECTIVES: Atopic dermatitis is a common, chronic, debilitating disease. Poor adherence to treatment is the most important preventable contributor to adverse outcomes. Thus, improving adherence can improve patient outcomes. Text message reminders with embedded condition-specific information have been shown to improve pediatric immunization adherence but have not been assessed in atopic dermatitis. The objective was to assess the effect of daily text messages on Eczema Area Severity Index scores and caregiver knowledge of atopic dermatitis...
May 2, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29691908/expression-of-cutaneous-immunity-markers-during-infant-skin-maturation
#17
Frank Kirchner, Kimberly A Capone, M Catherine Mack, Georgios N Stamatas
BACKGROUND/OBJECTIVES: Infant skin undergoes a maturation process during the early years of life. Little is known about the skin's innate immunity. We investigated the dynamics of innate immunity markers collected from the surface of infant skin during the first 36 months of life. METHODS: A total of 117 healthy infants aged 3-36 months participated in the study. We extracted human beta defensin-1 and interleukin 1 alpha and its receptor antagonist using transdermal analysis patches from the skin surface of the posterior lower leg area...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29691886/cutaneous-langerhans-cell-histiocytosis-presenting-with-hypopigmented-lesions-report-of-two-cases-and-review-of-literature
#18
Shoko Mori, Tony Adar, Viktoryia Kazlouskaya, Jaime B Alexander, Edward Heilman, Sharon A Glick
Langerhans cell histiocytosis is a rare group of disorders that results from the abnormal proliferation and accumulation of dendritic-derived cells in various organs of the body, such as the skin and bones. Hypopigmented macules are a rare cutaneous presentation of Langerhans cell histiocytosis that may pose a diagnostic dilemma when no other findings of Langerhans cell histiocytosis are present at the time of examination. We present 2 cases of the hypopigmented variant of Langerhans cell histiocytosis, including a case with histopathologic features of regression, and a review of the literature...
April 25, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29683225/utility-of-routine-electrocardiographic-screening-before-initiation-of-propranolol-for-infantile-hemangiomas
#19
Emily B Lund, Sarah L Chamlin, Anthony J Mancini
Screening electrocardiography (ECG) before initiation of propranolol for treatment of infantile hemangiomas (IH) is controversial. A retrospective chart review was conducted to assess the utility of pretreatment ECG in infants with IH starting propranolol. Although nearly half of the ECGs were abnormal, no contraindications to treatment were identified from screening ECG, and no association was found between any of the reported side effects and abnormal ECG. These results support previously published data, and in a larger cohort, providing further confirmation that pretreatment ECG is not necessary in most infants with IH...
April 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29683223/mycophenolate-mofetil-to-treat-mid-dermal-elastolysis
#20
Sarah L Smithson, David Orchard, Laura Scardamaglia
Mid-dermal elastolysis is an acquired skin condition affecting the elastin fibers of the dermis, resulting in laxity of the skin. We report a case of mid-dermal elastolysis for which novel treatment with mycophenolate mofetil was successful.
April 23, 2018: Pediatric Dermatology
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