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Pediatric Dermatology

Angela Burleigh, Nordau Kanigsberg, Joseph M Lam
The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the use of topical rapamycin in other dermatologic conditions is summarized to aid in clinical decision making on preparations and anticipated side effects.
July 17, 2018: Pediatric Dermatology
Andre V Moyakine, Saskia Spillekom-van Koulil, Elselien M Küpers, Catharina J M van der Vleuten
BACKGROUND: Quality of life (QoL) data are lacking in children with infantile hemangioma (IH) and their parents/caregivers. Available data are conflicting. OBJECTIVES: To determine QoL of (parents of) patients with IH in the proliferative phase related to IH-severity and activity. METHODS: Parents of 59 IH-patients (≤ 6 months) were asked to fill in the Dutch IH-specific QoL-questionnaire (D-IH-QoL) within 1 month after their first visit to our tertiary referral center...
July 17, 2018: Pediatric Dermatology
(no author information available yet)
No abstract text is available yet for this article.
July 12, 2018: Pediatric Dermatology
Huaijie Wang, Xinkui Guo, Yitao Duan, Baijun Zheng, Ya Gao
BACKGROUND: Sirolimus has been used to manage various complex vascular anomalies. Kaposiform hemangioendothelioma and tufted angioma may develop Kasabach-Merritt phenomenon in infancy. METHODS: We retrospectively reviewed the clinical and laboratory data of eight patients with kaposiform hemangioendothelioma and tufted angioma who were initially treated using oral sirolimus in our center, including six with Kasabach-Merritt phenomenon. RESULTS: Five girls and three boys seen between September 2012 and March 2015 were included...
July 12, 2018: Pediatric Dermatology
Vikash S Oza, Thomas Stringer, Caren Campbell, Brian Hinds, Sarah L Chamlin, Ilona J Frieden, Sonal Shah
BACKGROUND/OBJECTIVES: Congenital juvenile xanthogranulomas are infrequently described in the medical literature. We report three previously unpublished cases and systematically review the literature to better characterize this variant. METHODS: We surveyed English-language articles indexed in MEDLINE (1951-March 2017) and EMBASE (1974-March 2017) for cases of congenital-onset juvenile xanthogranulomas confirmed on histopathology. Cases were divided into two categories: cutaneous only or cutaneous with systemic involvement...
July 12, 2018: Pediatric Dermatology
Daniel de la Rosa Carrillo, Harald Vindenes, Veronica A Kinsler, Arild Rønnestad, Geir Ringstad, Lil-Sofie Ording Müller, Svetlana Tafjord, Kim A Tønseth, Bjørn Kvamme, Ole Petter Fraas Clausen
We report the case of a newborn boy with multinodular NRAS and BRAF mutation-negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age...
July 12, 2018: Pediatric Dermatology
Erin C Dunn, Kevin J Moore, Feng Miao, Robert S Kirsner, Tulay Koru-Sengul
BACKGROUND/OBJECTIVES: Although pediatric and young adult skin cancer is uncommon, recent epidemiologic studies have shown pediatric melanoma to be on the rise in the United States. Using a population-based cancer registry, this study examined skin cancer burden and survival disparities in children and young adults. METHODS: Linked data from the Florida Cancer Data System and U.S. Census were analyzed to elucidate skin cancer burden distribution and survival disparities in 1543 Florida children (0-9 years), adolescents (10-19 years), and young adults (20-24 years)...
July 12, 2018: Pediatric Dermatology
Vernon M Bowles, Lisa Jenkins VanLuvanee, Hugh Alsop, Lydie Hazan, Katie Shepherd, Srinivas Sidgiddi, Kent Allenby, Tiina Ahveninen, Sharon Hanegraaf
BACKGROUND: There is a need for better control of head louse infestations. Abametapir is an inhibitor of metalloproteinases critical for louse survival and egg development. The efficacy of abametapir lotion, 0.74%, was assessed for its ability to clear head louse infestations after a single application. METHODS: Two randomized, double-blind, multicenter, vehicle-controlled studies were conducted in subjects aged 6 months and older to compare the effectiveness of abametapir lotion versus vehicle control for eliminating head louse infestations without nit combing...
July 12, 2018: Pediatric Dermatology
Ashley M Yu, Shinya Ito, Tom Leibson, Sasson Lavi, Lisa W Fu, Miriam Weinstein, Sandra M Skotnicki
A 4-year-old boy presented with erythematous vesicular plaques, ulceration, edema, and pruritus on the left foot and ankle 10 days after receiving the tetanus, diphtheria, pertussis, and polio; measles, mumps, rubella, and varicella; and hepatitis A/B vaccines. Biopsy showed eosinophilic infiltrates and flame figures, suggesting Wells syndrome. Patch testing showed a 1+ reaction to neomycin and aluminum hydroxide, with a recall reaction of Wells syndrome of the feet bilaterally. We report a rare case of pediatric Wells syndrome triggered by nonthimerosal vaccine components confirmed by patch testing...
July 12, 2018: Pediatric Dermatology
Marta Valdivielso-Ramos, Antonio Torrelo, Ana Martin-Santiago, Minia Campos, Elena Conde, Pablo de la Cueva, Juan Carlos Lopez-Gutierrez
BACKGROUND: Infantile hemangiomas with minimal or arrested growth are vascular tumors with a proliferative component involving < 25% of their total surface area. They are commonly described as localized lesions and are mainly located on the lower body. Little has been described about segmental forms on the face and their associations with PHACE syndrome. METHODS: We carried out a multicenter, retrospective, case-series study involving 5 hospitals in Spain. Information was collected on cases of PHACE syndrome featuring infantile hemangiomas with minimal or arrested growth...
July 9, 2018: Pediatric Dermatology
Anna C Tappel, Nicole Cresce, Barrett Zlotoff
BACKGROUND/OBJECTIVES: Atopic dermatitis is an inflammatory skin condition with significant disease burden. Bibliotherapy, the use of storybooks to understand an illness, has been proven effective in several pediatric disorders but has not been studied in dermatologic disease. The purpose of this study was to assess the availability of storybooks about atopic dermatitis and analyze them based on adherence to American Academy of Dermatology guidelines for the treatment of atopic dermatitis, readability, author qualifications, cost, and availability...
July 9, 2018: Pediatric Dermatology
Burak Tekin, Mehmet Salih Gurel, Zeynep Topkarci, Filiz Topaloglu Demir, Sema Aytekin, Filiz Cebeci Kahraman, Ralfi Singer, Vefa Asli Erdemir, Tugba Kevser Uzuncakmak, Sirin Yasar, Necmettin Akdeniz, Ilknur Kivanc Altunay, Emek Kocaturk, Zafer Turkoglu, Bilgen Erdogan
BACKGROUND/OBJECTIVES: The effect of pediatric psoriasis on quality of life has been demonstrated, but data regarding its influence on caregiver quality of life are scarce. The objective was to investigate how psoriasis affects quality of life of children and their caregivers. METHODS: This multicenter study included 129 children with psoriasis and their caregivers, who were family members accompanying patients to the clinic. Patient quality of life was measured using the Child Dermatology Life Quality Index...
July 9, 2018: Pediatric Dermatology
Margaret H Dennin, Margaret S Lee
Body dysmorphic disorder is an obsessive-compulsive spectrum disorder involving a perceived defect in physical appearance that most commonly develops in early adolescence and causes significant functional impairment and suicidality at much higher rates than in affected adults. Patients may also present with subthreshold body dysmorphic disorder or obsessive concerns over a diagnosable dermatologic condition, both of which can present similarly to body dysmorphic disorder. Pediatric dermatologists can play an important role in detecting body dysmorphic disorder and body dysmorphic disorder-like symptoms, which may occur in as many as 20% of dermatology patients...
July 9, 2018: Pediatric Dermatology
Kaiane Habeshian, Kylie Fowler, Veronica Gomez-Lobo, Kalyani Marathe
To our knowledge, there are no guidelines in the dermatology literature for performing anogenital examinations in prepubescent children. Based on experience in our joint pediatric dermatology-gynecology vulvar clinic, we aim to provide a framework for conducting genital examinations in children, focusing on the vulvar examination. Our goal is to enhance confidence in the pediatric dermatologist's ability to perform thorough examinations by providing general principles as well as concrete "do's" and "don'ts" that will create a maximally comfortable and productive experience...
July 4, 2018: Pediatric Dermatology
Marta Bertolin-Colilla, Rebeca Alcalá, Gustavo Deza, Luciano Polino, Fernando Gallardo, Ramon M Pujol
Inflammatory linear verrucous epidermal nevus and linear psoriasis are different entities with clinical and histopathologic similarities. Isolated reports of inflammatory linear verrucous epidermal nevus with concomitant psoriasis or a positive family history of psoriasis have been described, and the possibility that inflammatory linear verrucous epidermal nevus may be a mosaic form of cutaneous psoriasis has been postulated. We report a 17-year-old boy with a congenital, linear, erythematous, keratotic plaque on the dorsum of the fifth finger of the left hand with ipsilateral nail dystrophy...
July 4, 2018: Pediatric Dermatology
Blair Simpson, Cristina Tarango, Anne W Lucky
Epidermolysis bullosa is a group of rare genetic disorders with multiple organ system involvement. In one severe form, recessive dystrophic epidermolysis bullosa, chronic anemia is common. This report outlines the multifactorial nature of anemia in recessive dystrophic epidermolysis bullosa and presents a practical clinical algorithm based on expert consensus for the diagnosis and treatment of anemia in recessive dystrophic epidermolysis bullosa.
July 4, 2018: Pediatric Dermatology
Paul L Aronson
No abstract text is available yet for this article.
July 4, 2018: Pediatric Dermatology
Christina S Manice, Paul J Planet, Herbert S Chase, Christine T Lauren
OBJECTIVES: To assess the management and outcomes of vesicles and pustules in afebrile neonates presenting to the pediatric emergency department. METHODS: Using International Classification of Diseases, Ninth Revision, codes, we identified patients 0-60 days old presenting to our pediatric emergency department from 2008 to 2015 with a possible diagnosis of pustules or vesicles. We then used natural language processing followed by manual chart review to identify afebrile neonates with pustules or vesicles...
July 4, 2018: Pediatric Dermatology
Richard E Watchorn, Eduardo Calonje, Saleem M Taibjee
BRCA1-associated protein 1(BAP1) inactivated melanocytic nevi are pink to tan and dome-shaped in clinical appearance, resembling dermal nevi, but with distinct histologic features of two melanocytic subpopulations: larger atypical melanocytes and nests of smaller, blander nevoid melanocytes. Pedigrees with BAP1 mutations are at greater risk of various malignancies. We report the case of a 16-year-old boy with multiple benign-appearing nevi, all demonstrating loss of BAP1 on immunohistochemistry. History revealed that his father had died of paraganglioma, which is also associated with BAP1 mutations...
July 4, 2018: Pediatric Dermatology
Laura Atzori, Marialuisa Corbeddu, Marzia Mou, Luca Pilloni, Franco Rongioletti
Molluscum contagiosum within a congenital melanocytic nevus has rarely been reported. We report a 6-year-old child with molluscum contagiosum infection arising within an intermediate melanocytic congenital nevus of the thigh, associated with itching and occasional bleeding. Dermoscopy lead to the correct diagnosis, but histologic confirmation with shave biopsy was performed to reassure the parents and allow mechanical removal of the lesions using curettage.
July 4, 2018: Pediatric Dermatology
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