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Pediatric Dermatology

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https://www.readbyqxmd.com/read/28044367/bilateral-half-head-comparison-of-1-anthralin-ointment-in-children-with-alopecia-areata
#1
Mustafa Özdemir, Ali Balevi
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. METHODS: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment...
January 3, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28025844/cross-sectional-study-evaluating-skin-hair-nail-and-bone-disease-in-patients-with-focal-dermal-hypoplasia
#2
Nicole S Gunasekera, Joan K Divito, Thomas S Kupper, Jennifer T Huang, Sherrie J Divito
Focal dermal hypoplasia (FDH) is an X-linked dominant disease characterized by dermal thinning and fat herniation with other ectodermal and mesodermal abnormalities. There is limited literature regarding the symptomatology and progression of skin, hair, and nail disease. The risk of bone fragility has not been explored either. This cross-sectional survey-based study explored these gaps in knowledge and provides direction for future avenues of research in FDH.
December 26, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/28008652/multiple-milia-as-an-isolated-skin-manifestation-of-dominant-dystrophic-epidermolysis-bullosa-evidence-of-phenotypic-variability
#3
Eijiro Akaksa, Hajime Nakano, Yuriko Takagi, Yuka Toyomaki, Daisuke Sawamura
We report a Japanese pedigree with dominant dystrophic epidermolysis bullosa (DDEB) harboring the p.G2251E mutation of COL7A1. The proband of this pedigree presented with multiple milia as an isolated skin manifestation without a history of blistering and subsequently developed generalized intractable blisters, suggesting that multiple milia could be a primary manifestation of DDEB. Her mother exhibited nail dystrophy and pruritic nodules and her elder sister was unaffected, despite having the same COL7A1 mutation...
December 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/28008647/palmoplantar-keratoderma-in-costello-syndrome-responsive-to-acitretin
#4
Nareh V Marukian, Jonathan L Levinsohn, Brittany G Craiglow, Leonard M Milstone, Keith A Choate
Costello syndrome (CS) is a multisystem congenital disorder characterized by coarse facial features, cardiac defects, intellectual disability, and predisposition to malignancies. Dermatologic findings can include cutaneous papillomas, skin redundancy, acanthosis nigricans, and keratosis pilaris. Palmoplantar keratoderma (PPK) is present in approximately 76% of patients with CS, with disabling functional consequences in severe cases. We report a case of CS with severe PPK that improved dramatically with systemic administration of acitretin 0...
December 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27990680/retrospective-study-of-rocky-mountain-spotted-fever-in-children
#5
Rechelle Tull, Christine Ahn, Alyssa Daniel, Gil Yosipovitch, Lindsay C Strowd
BACKGROUND/OBJECTIVES: Rocky Mountain spotted fever (RMSF), a lethal tick-borne illness, is prevalent in the south central United States. Children younger than 10 years old have the greatest risk of fatal outcome from RMSF. The objective of the current study was to review pediatric cases of RMSF seen in the dermatology consult service and to evaluate dermatology's role in the diagnosis and management of this disease. METHODS: A retrospective review was performed of inpatient dermatology consultations at a tertiary care center in North Carolina from 2001 to 2011...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27990674/nationwide-survey-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-children-in-the-united-states
#6
Yusuke Okubo, Kotaro Nochioka, Marcia A Testa
Although Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, life-threatening reactions to drug therapies, no efforts have been made to investigate the comprehensive change in epidemiology with respect to age, sex, and race and ethnicity in children. The risk of death was 0.3% to 1.5%, and the highest hospitalization rates were in children 15 to 19 years of age, boys, and black children. The highest proportions of hospitalizations were children with very low household income, those with private insurance, and those treated at large urban teaching hospitals in the West...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27990673/trichodysplasia-spinulosa-in-a-7-year-old-boy-managed-using-physical-extraction-of-keratin-spicules
#7
Michael Barton, Suing Lockhart, Robert Sidbury, Richard Wang, Heather Brandling-Bennett
Trichodysplasia spinulosa (TS) is an uncommon skin disease characterized by a folliculocentric papular eruption and keratin spine formation, classically appearing on the central face and ears. It occurs in immunosuppressed patients and is linked to a viral etiology. Diagnostic tests including polymerase chain reaction (PCR) are available for detection of the TS-associated polyomavirus. Effective treatment options include topical cidofovir and oral valganciclovir. We present a case diagnosed using PCR with skin scrapings and treated using physical extraction of the keratin spicules...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981628/concurrent-pemphigus-foliaceus-and-graves-disease
#8
Rachel Laarman, Kimberly A Horii
Pemphigus foliaceus (PF) is an uncommon immunobullous disease in children. Other autoimmune diseases have rarely been reported in children with PF. We report the case of an adolescent girl who presented with concurrent PF and Graves' disease.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981627/characteristics-of-pediatric-scrub-typhus-eschar-in-south-indian-children
#9
Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Shanthi Ananthakrishnan
BACKGROUND: Knowledge of anatomic location of eschar is useful in diagnosing scrub typhus early in children and to initiate appropriate treatment. METHODS: All children younger than 12 years of age admitted with confirmed diagnosis of scrub typhus over a 17-month period were included and the presence of eschar and other characteristics were recorded and analyzed. RESULTS: Of 107 confirmed patients with scrub typhus, 37 (34.6%) presented with eschar...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981626/regression-of-nevi-after-candida-injection-for-the-treatment-of-verruca-vulgaris
#10
Emily Kollmann, David Cleaver, Lloyd Cleaver, Jonathan Cleaver
The most common treatment methods for verruca vulgaris are destructive methods that are often painful and treat individual verruca. Thus immune modulators, including Candida immunotherapy, are used to treat persistent recalcitrant and multiple verrucas simultaneously. Very few side effects are reported with Candida immunotherapy; they include vitiligo and now halo nevi. Physicians need to be aware of and discuss side effects with patients undergoing Candida immunotherapy.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981625/plaque-like-myofibroblastic-tumor-of-infancy-a-new-case-report-and-literature-review
#11
Francesco Alesini, Giuseppe Soda, Francesca Gianno, Alessandro Boscarelli, Denis A Cozzi, Sandro Bosco
Plaque-like myofibroblastic tumor of infancy is a rare entity, with only a few reports described in the literature. Herein we present a new case of a nodular plaque-like lesion of the left lower back in an 18-month-old boy. The lesion might initially be thought to be a dermatofibroma, but the overall characteristics suggested the diagnosis of plaque-like myofibroblastic tumor of infancy. We also provide a summary of previous reports in the literature about this exceptional tumor.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981623/central-centrifugal-cicatricial-alopecia-in-children-a-case-series-and-review-of-the-literature
#12
Ariana N Eginli, Ncoza C Dlova, Amy McMichael
BACKGROUND/OBJECTIVES: Central centrifugal cicatricial alopecia (CCCA) is a form of scarring hair loss most commonly seen in middle-aged African and African American women. It is rarely reported in children. The objective of the current study was to document the presence of CCCA in children and to encourage physicians to recognize early signs of CCCA in children of affected adults. METHODS: Six children presented with biopsy-proven CCCA to the Department of Dermatology at Wake Forest Baptist Health and the Nelson R...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981622/successful-treatment-of-vitiligo-associated-with-vogt-koyanagi-harada-disease
#13
Michelle L Bayer, Yvonne E Chiu
Vogt-Koyanagi-Harada disease (VKH) is a rare multisystem disorder with cutaneous, ophthalmic, neurologic, and auditory manifestations. There is a paucity of published literature regarding the management of cutaneous features in VKH. We report a case of VKH-associated vitiligo responsive to topical corticosteroids and topical calcineurin inhibitors.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981619/familial-progressive-hyperpigmentation-cutaneous-mastocytosis-and-gastrointestinal-stromal-tumor-as-clinical-manifestations-of-mutations-in-the-c-kit-receptor-gene
#14
Tatiana Piqueres-Zubiaurre, Zuriñe Martínez de Lagrán, Ricardo González-Pérez, Amaia Urtaran-Ibarzabal, Guiomar Perez de Nanclares
BACKGROUND: Familial progressive hyperpigmentation (FPH) is an autosomal dominant disorder characterized by the appearance of hyperpigmented patches on the skin from early infancy that increase in size and number with age. METHODS: We report the clinical and molecular studies of an 11-year-old boy who had areas of hyperpigmentation since birth that had spread across his body as irregular hyperpigmented macules and papules, and include relevant history in family members...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981618/access-to-genetic-diagnostics-for-genodermatoses-who-should-get-tested-why-who-pays
#15
EDITORIAL
Eoin R Storan, Alan D Irvine
No abstract text is available yet for this article.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981617/utility-of-the-hemangioma-severity-scale-as-a-triage-tool-and-predictor-of-need-for-treatment
#16
Jamie L Mull, Sarah L Chamlin, Jin-Shei Lai, Jennifer L Beaumont, David Cella, Elizabeth A Rancour, Eulalia Baselga, Anita N Haggstrom
BACKGROUND/OBJECTIVES: Infantile hemangiomas (IHs) are commonly encountered in primary care and most often remain asymptomatic, resolving without sequelae. Certain characteristics are associated with a greater risk of complications, associated anomalies, and disfigurement. The heterogeneous presentation poses a clinical challenge for physicians in determining the need for treatment and subspecialty referral. This study aims to evaluate the utility of the previously published Hemangioma Severity Scale (HSS) to predict the need for treatment...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981606/evaluation-of-cutaneous-findings-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-preliminary-study
#17
Hilal Kaya Erdogan, Saniye Tulin Fıdan, Isil Bulur, Tekden Karapınar, Zeynep Nurhan Saracoglu
Attention deficit hyperactivity disorder (ADHD) is characterized by attention, concentration, mobility, and impulse control problems and is among the most frequently seen psychiatric disorders during childhood. Our aim was to evaluate cutaneous findings in children and adolescents with ADHD. In our study we found that onychophagy, traumatic skin changes, atopy and related symptoms, certain birthmarks, and acne were frequent cutaneous findings in children with ADHD. Although a limitation is the lack of a control group, ADHD is very common, and our study suggests that further studies of cutaneous findings and ADHD are warranted...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27874216/complementary-and-alternative-therapies-used-by-patients-of-pediatric-dermatology-outpatient-clinics-in-turkey-a-multicenter-study
#18
Burce Can, Hülya Akan, Filiz Topaloglu Demir, Ilkin Zindanci, Filiz Cebeci, Zafer Turkoglu, Mukaddes Kavala
BACKGROUND: The aim of this study was to determine the frequency of complementary and alternative medicine (CAM) methods used in children and adolescents with chronic skin diseases, which methods parents prefer, and to what extent these methods are useful. MATERIAL AND METHODS: This cross-sectional study was conducted between June and November 2014 in patients with chronic skin diseases attending the outpatient pediatric dermatology clinics of three hospitals in Turkey...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27874213/questioning-the-clinical-utility-of-exome-sequencing-in-developing-countries
#19
Kenneth Fong, Celeste V Bailey, Peggy Tuttle, Bari Cunningham, John A McGrath, Raymond J Cho
The availability of whole-exome sequencing has revolutionized the study of genetic disease in recent years, particularly in dermatology, where clinical phenotypes are readily recognized. As this technology becomes increasingly affordable and accessible, questions are emerging regarding the clinical and ethical responsibilities of physicians who determine variants underlying disease, especially with regard to children, for whom treatment may be warranted and clinical course improved based on a known genotype...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#20
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
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