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Pediatric Dermatology

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https://www.readbyqxmd.com/read/28804956/spontaneous-regression-of-a-nail-matrix-melanocytic-nevus-in-a-child
#1
Austin John Maddy, Antonella Tosti
A 14-year-old Hispanic boy presented with a 0.25-mm wide, sharply demarcated, dark brown band of longitudinal melanonychia of the left thumbnail. A clinical diagnosis of nail matrix nevus was made and the boy was scheduled for follow-up. The band showed proximal fading after 6 months and had completely faded after 11 months, with the proximal nail fold showing small dark brown dots on dermoscopy. We documented the spontaneous regression of melanonychia over 11 months.
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28804924/flagellate-dermatitis-in-a-child-most-likely-secondary-to-doxorubicin
#2
Darosa Lim, Marine Aussedat, Nicole Maillet-Lebel, Danielle Marcoux
Flagellate dermatitis, a cutaneous eruption in which the patient appears to have been whipped, has been described with antineoplastic agents and shiitake mushroom ingestion. A 15-year-old girl with metastatic Ewing sarcoma developed pruritic erythematous linear lesions on her trunk that became hyperpigmented over time during her first cycle of chemotherapy with doxorubicin, vincristine, cyclophosphamide, and ganitumab. Flagellate dermatitis was diagnosed based on clinical and histologic findings. Flagellate dermatitis (FD) is a rare cutaneous eruption named for its appearance, in which the patient appears to have been whipped...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28804923/hypopigmented-mycosis-fungoides-with-large-cell-transformation-in-a-child
#3
Dinesh Pradhan, Jaroslaw J Jedrych, Jonhan Ho, Oleg E Akilov
Hypopigmented mycosis fungoides (HMF) is the most common variant of mycosis fungoides (MF) in children. Large-cell transformation in HMF has never been reported. Herein we report a case of HMF in an 8-year-old boy who presented with a 6-year history of hypopigmented patches on the bilateral arms, lower back, buttocks, posterior thighs, and lower legs. Biopsy revealed an abnormal CD8(+) epidermotropic T-cell infiltrate consistent with the diagnosis of MF. The T-cell clonality study was positive. The patient was started on narrowband ultraviolet B (NBUVB) phototherapy and topical steroids...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28804922/study-of-cognitive-function-in-children-treated-with-propranolol-for-infantile-hemangioma
#4
Nieves González-Llorente, Isabel Del Olmo-Benito, Natalia Muñoz-Ollero, Miguel Angel Descalzo, Ignacio García-Doval, Antonio Torrelo
BACKGROUND: Oral propranolol is considered the first choice for the treatment of infantile hemangiomas (IHs). There is a concern that administering propranolol in newborns and infants could induce adverse effects in learning and memory processes in the long term. The purpose of this study was to assess cognitive and memory functions in children who had been treated with propranolol for IH during their infancy. METHODS: A total of 23 children between 5 and 7.5 years of age who had been treated with oral propranolol for IH during infancy were tested for cognitive functions with the Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (WPPSI-IV) test and for memory functions with the Test of Memory and Learning (TOMAL)...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28804919/clinical-outcome-and-prognosis-of-young-patients-with-mycosis-fungoides
#5
Pooja Virmani, Laura Levin, Patricia L Myskowski, Eileen Flores, Michael A Marchetti, Anna Skripnik Lucas, Melissa Pulitzer, Steven Horwitz, Tanya Trippett, Alison Moskowitz, Christiane Querfeld
BACKGROUND/OBJECTIVES: Mycosis fungoides (MF) in young patients is rare and may have atypical presentations. There are limited data in these patients. The objective was to determine the clinical outcome and prognosis of young patients with MF. METHODS: A search of our institutional cancer registry database was conducted for patients diagnosed with MF at younger than 30 years of age. RESULTS: Our study included 74 patients (median age at diagnosis 25...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28804916/lane-s-disease-erythema-palmare-hereditarium-a-report-of-five-cases-and-a-review-of-the-literature
#6
Carlotta Gurioli, Annalisa Patrizi, Martina Lambertini, Iria Neri
BACKGROUND: Erythema palmare hereditarium (EPH), also known as Lane's disease, is a rare, benign condition presenting as persistent erythema involving the palms. EPH can appear at birth or later in life and usually in at least two members of the same family, although a sporadic case has been reported. METHODS: We report five cases of EPH and offer a review of the current literature. The first and second cases are twin boys presenting with erythema mainly on the thenar and hypothenar eminences and on the phalanges that appeared 8 months after birth...
August 14, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28783214/punch-and-scoop-technique-for-removing-pilomatricoma
#7
Eric L Maranda, Farhaad Riyaz, Tor Shwayder
Pilomatricomas are benign calcifying neoplasms derived from follicle matrix cells. Standard treatment for pilomatricomas involves complete surgical excision, with an overall low rate of recurrence. We discuss a simple alternative surgical technique that allows for removal of the lesion with less residual defect than complete excision.
August 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28783212/giant-cutaneous-horn-arising-in-an-epidermal-nevus
#8
Michael A Cardis, Anna Yasmine Kirkorian
Cutaneous horns, which rarely occur in children, can overlie a large array of pathologic lesions that range from benign to malignant. When a cutaneous horn is encountered, it is not the horn itself that is of relevance, it is the nature of the underlying disease that dictates overall prognosis and management. In this report we present a case of a cutaneous horn arising within a linear verrucous epidermal nevus and briefly review cutaneous horns, with an emphasis on their clinical implications and differential diagnosis...
August 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28783211/nomalike-necrotizing-stomatitis-in-a-child-with-crohn-s-disease
#9
Ye Jin Lee, Young Jae Kim, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi
Noma is an opportunistic infection characterized by devastating gangrenous stomatitis leading to severe tissue destruction that predominantly affects malnourished children in sub-Saharan Africa. Only a few cases have been reported in immunocompromised patients from developed countries. We present an unusual case of nomalike necrotizing stomatitis in a previously healthy child with Crohn's disease in Korea.
August 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28771811/idiopathic-calcinosis-cutis-universalis-treated-successfully-with-oral-diltiazem-a-case-report
#10
Jayanti Singh, Vijay K Paliwal, Puneet Bhargava, Deepak K Mathur
Idiopathic calcinosis cutis is very rare and difficult to treat. Various medical modalities of treatment described with inconsistent results include chelating agents, colchicine, and probenecid. Calcium channel blockers are known to work by inhibiting intracellular entry of calcium. We successfully treated a case of idiopathic calcinosis cutis using oral diltiazem.
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28771805/cutaneous-small-vessel-vasculitis-in-two-children-with-inflammatory-bowel-disease-case-series-and-review-of-the-literature
#11
Tina Ho, Lauren A V Orenstein, Markus D Boos, Kevin P White, Nicole Fett
Cutaneous small-vessel vasculitis (CSVV) is an infrequent manifestation of pediatric inflammatory bowel disease (IBD). We report two cases of CSVV associated with ulcerative colitis, review the literature, and discuss the diagnostic evaluation of children who present with CSVV and abdominal pain. After excluding more common causes of CSVV and abdominal pain in children, including immunoglobulin A vasculitis (previously Henoch-Schönlein purpura), infectious colitis, and drug-induced vasculitis, alternative diagnoses such as CSVV secondary to IBD or systemic vasculitis with gastrointestinal involvement must be considered...
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28771804/palmar-eccrine-hidradenitis-secondary-to-trauma-from-computer-gaming-in-an-adolescent-after-bone-marrow-transplantation
#12
Lynette Ying Lee, Mark Jean-Aan Koh
A 14-year-old boy who had undergone a matched sibling bone marrow transplant for acute lymphoblastic leukemia presented with painful nodules on his palms after prolonged gaming on his computer and mobile phone. Histology showed a neutrophilic inflammatory infiltrate surrounding the acrosyringium and eccrine sweat coils in the deep dermis. The lesions resolved spontaneously with conservative management.
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28771801/tuberous-sclerosis-complex-in-29-children-clinical-and-genetic-analysis-and-facial-angiofibroma-responses-to-topical-sirolimus
#13
Senfen Wang, Yuanxiang Liu, Jinghai Wei, Jian Zhang, Zhaoyang Wang, Zigang Xu
BACKGROUND/OBJECTIVES: Tuberous sclerosis complex (TSC) is a genetic disorder and facial angiofibromas are disfiguring facial lesions. The aim of this study was to analyze the clinical and genetic features of TSC and to assess the treatment of facial angiofibromas using topical sirolimus in Chinese children. METHODS: Information was collected on 29 patients with TSC. Genetic analyses were performed in 12 children and their parents. Children were treated with 0.1% sirolimus ointment for 36 weeks...
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28770583/can-you-see-me-now-video-supplementation-for-pediatric-teledermatology-cases
#14
Dana F Feigenbaum, Christy K Boscardin, Ilona J Frieden, Erin F D Mathes
BACKGROUND/OBJECTIVES: Digital video is widely available and is used sporadically in clinical settings to evaluate patients, but whether it helps improve clinical management has not been determined. The aim of this study was to assess whether recorded video in addition to still images can improve residents' diagnostic and management accuracy and confidence with pediatric teledermatology cases. METHODS: Dermatology residents from three programs were assigned alternately to an online survey with 15 pediatric teledermatology cases presented with still images only (still) or still images plus recorded video (mixed)...
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28758317/eccrine-chromhidrosis-in-an-adolescent-with-sickle-cell-disease
#15
Jong G Park, Neil S Prose, Reed Garza
Eccrine chromhidrosis can occur secondary to hyperbilirubinemia. We report an adolescent with sickle cell disease who presented with eccrine chromhidrosis on his palmar and plantar surfaces. He had extremely high levels of conjugated bilirubin but no fever. This is the youngest known reported patient with eccrine chromhidrosis and the first in a patient with sickle cell disease.
July 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28758315/acanthosis-nigricans-and-its-response-to-metformin
#16
Dinesh Giri, Hussain Alsaffar, Renuka Ramakrishnan
Acanthosis nigricans (AN) is the most common cutaneous manifestation of insulin resistance (IR) and is commonly seen in non-Caucasian populations. Variable benefits of metformin in the treatment of AN have been reported in the literature. We report an adolescent Caucasian boy with IR and extensive AN who showed complete resolution of AN after 2 years of metformin, despite persistence of IR.
July 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28758247/pulsed-dye-laser-treatment-of-port-wine-stains-in-children-useful-tips-to-avoid-general-anesthesia
#17
Adrián Alegre-Sánchez, Bibiana Pérez-García, Pablo Boixeda
Pulsed dye laser (PDL) treatment of port-wine stains (PWSs) in children is a common procedure performed in most laser units. Pain assessment in our younger patients is a major concern, especially in those with extensive PWSs. The use of general anesthesia (GA) results in pain-free treatment, but its effects on the developing brain are far from totally understood. Thus we propose some tips that avoid the use of GA in most of our young patients, including the use of topical anesthetics and cooling systems, large laser spot size and high frequencies, early and frequent treatment with parents present, and the "introduction" and "pressure" techniques, among others...
July 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28730754/diffuse-hepatic-hemangiomas-successfully-treated-using-sirolimus-and-high-dose-propranolol
#18
Donald Warren, Lucia Diaz, Moise Levy
Diffuse hepatic hemangiomas are a challenging disease that can be life threatening. We present the case of an infant with diffuse hepatic hemangiomas who failed first-line therapies but later responded to sirolimus and high-dose propranolol.
July 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28730721/ephb4-mutation-implicated-in-capillary-malformation-arteriovenous-malformation-syndrome-a-case-report
#19
JiaDe Yu, Jenna L Streicher, Livija Medne, Ian D Krantz, Albert C Yan
Capillary malformation-arteriovenous malformation (CM-AVM) syndrome, due to inactivating mutations in RASA1 in 68% of cases, is characterized by the development of cutaneous capillary malformations and arteriovenous malformations or fistulas; no known genetic etiology has been identified in patients with CM-AVM syndrome without RASA1 mutations. We present the case of a child with RASA1-negative CM-AVM syndrome with a de novo missense mutation in EPHB4, a transmembrane tyrosine kinase receptor essential for vasculogenesis...
July 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28730670/molluscum-contagiosum-like-presentation-of-langerhans-cell-histiocytosis-a-case-and-review
#20
Matthew S Karpman, Mohammed I AlJasser, Joseph M Lam
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells in the skin. A molluscum-like presentation of cutaneous LCH is rare but important to consider for examination and management. We present an atypical molluscum-like LCH case and review the literature for common features of this unusual presentation.
July 21, 2017: Pediatric Dermatology
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20219
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