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Pediatric Dermatology

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https://www.readbyqxmd.com/read/28436109/efficiency-of-ustekinumab-in-crohn-s-disease-with-severe-psoriasiform-rash-induced-by-biotherapies-in-an-adolescent
#1
Valérie Bertrand, Abdelaziz El Haite, Delphine Carré
Ustekinumab is approved for the treatment of psoriasis in adolescents and for the treatment of moderate to severe Crohn's disease (CD) in adults, but data are lacking in pediatric CD. We report a case of severe psoriasis induced by biotherapies in an adolescent with CD that improved after switching to ustekinumab (90 mg at weeks 0, 2, and 4 and then every 8 weeks). The patient had not experienced CD relapse after 1 year of follow-up. Ustekinumab can be an alternative therapy for psoriasis induced by biotherapies when conventional treatment fails and can maintain remission of CD...
April 23, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28429544/an-innovative-cooling-jacket-to-combat-heat-intolerance-in-children-with-anhidrosis
#2
Arun C Inamadar, Aparna Palit, Neha Khurana
Hyperthermia and heat intolerance are distressing symptoms in patients with anhidrosis. Body cooling devices are an integral part of management of these patients. A cooling jacket made from easily available materials has been invented for a girl with congenital insensitivity to pain and anhidrosis with severe heat intolerance. This innovative cooling jacket may be helpful for anhidrotic children in resource-poor situations.
April 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28425139/dissecting-cellulitis-of-the-scalp-with-excellent-response-to-isotretinoin
#3
Kaitlin Marquis, Laura-Catherine Christensen, Anand Rajpara
An 18-year-old man presented for evaluation of a 1-year history of painful nodules on the scalp with associated hair loss. Physical examination revealed multiple confluent, fluctuant, boggy nodules on the scalp with overlying alopecic patches. Based on these findings, a diagnosis of dissecting cellulitis of the scalp was made and the patient was successfully treated with oral isotretinoin therapy.
April 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28425131/garlic-dermatitis-on-the-neck-of-an-infant-treated-for-nasal-congestion
#4
Amin Esfahani, Sarah L Chamlin
The health benefits of garlic (Allium sativum) as a naturopathic remedy have been well documented, but topical application of garlic has been linked to allergic and irritant contact dermatitis. We present a case of severe irritant contact dermatitis due to application of a fresh garlic necklace to the neck of infant for treatment of nasal congestion.
April 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28425111/-nails-only-phenotype-and-partial-dominance-of-p-glu170lys-mutation-in-a-family-with-epidermolysis-bullosa-simplex
#5
Álvaro González-Cantero, Ana Isabel Sánchez-Moya, Cristina Pérez-Hortet, Elena Martínez-Lorenzo, Blas Gómez-Dorado, Cristina Schoendorff-Ortega
Epidermolysis bullosa (EB) is a heterogeneous group of rare, chronic, inherited skin disorders characterized by marked mechanical fragility of epithelial tissues, with blistering and erosions after minor trauma. We present the first report of a nails-only phenotype in two patients with epidermolysis bullosa simplex (EBS) and a heterozygous pGlu170Lys mutation and the second reported case of EBS associated with a homozygous p.Glu170Lys mutation in the KRT5 gene. Our findings may be relevant for genetic counseling and for understanding the inheritance pattern of EBS...
April 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28419540/deep-granuloma-annulare-mimicking-inflamed-cysts-in-a-teenager
#6
Emily L Guo, Catherine A Degesys, Richard Jahan-Tigh, Audrey Chan
We describe deep granuloma annulare (DGA) of the forehead mimicking inflamed cysts. Reactive inflammation and sterile purulent drainage may be an underrecognized feature of DGA.
April 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28414858/keratoacanthoma-like-growths-of-incontinentia-pigmenti-successfully-treated-with-intralesional-methotrexate
#7
Brittany Barros, Klaus Helm, Andrea Zaenglein, Elizabeth Seiverling
We report the case of a 17-year-old girl with incontinentia pigmenti who developed multiple large hyperkeratotic tumors within Blaschkoid hyperpigmented patches on her left leg. Biopsy demonstrated an endoexophytic nodule with irregular invaginations of keratinizing squamous epithelium and a central keratin-filled crater, consistent with keratoacanthoma-like lesions of incontinentia pigmenti. The tumors were successfully treated with intralesional methotrexate.
April 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28382768/low-dose-cyclosporine-a-in-the-treatment-of-severe-atopic-dermatitis-complicated-by-chronic-hepatitis-c-virus-infection
#8
Maria Gnarra, Clara De Simone, Matteo Garcovich, Simone Garcovich
Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disorder in children and is usually accompanied by genetic and environmental factors. Effective management and treatment of AD is challenging and often requires systemic immunosuppressive therapy when refractory to topical treatments. We report a rare association between chronic hepatitis C virus (HCV) and severe AD, management of which required systemic cyclosporine because of its favorable effects on inflammatory and viral-related clinical outcomes...
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28382733/iatrogenic-calcinosis-cutis-successfully-treated-with-topical-sodium-thiosulfate
#9
Emilio García-García, Rocío López-López, Concepción Álvarez-Del-Vayo, José Bernabeu-Wittel
Calcinosis cutis is a term used to describe a group of disorders in which calcium salt deposits form in the skin and subcutaneous tissue. We report a 6-year-old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia being treated with calcium gluconate intravenous infusion through peripheral veins. Within a few days we made a diagnosis of iatrogenic calcinosis cutis and treatment with 10% topical sodium thiosulfate was prescribed; complete resolution of lesions was achieved after 6 months, with no local or systemic adverse effects...
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28382716/identical-presentation-of-scapular-osteolysis-in-two-patients-with-thoracic-kaposiform-hemangioendothelioma
#10
Verónica Alonso Arroyo, Juan Carlos Lopez-Gutierrez, Rox Martinez, Israel Fernandez-Pineda
Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that does not metastasize. We report two unique cases of KHE involving the right hemithorax and the upper ipsilateral extremity. Kasabach-Merrit phenomenon and osteolytic lesions in the scapula were observed in both cases.
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28382698/burden-of-infantile-hemangioma-on-family-an-international-observational-cross-sectional-study
#11
Christine Cazeau, Francine Blei, María Del Rosario Fátima Gonzáles Hermosa, Riccardo Cavalli, Olivia Boccara, Regina Fölster-Holst, Gilles Berdeaux, Alain Delarue, Jean-Jacques Voisard
BACKGROUND/OBJECTIVES: Infantile hemangioma (IH) is the most frequent benign tumor of infancy resulting from vascular proliferation. Data regarding the burden on families of children with IHs are limited. This study aimed to characterize IHs and provide a comprehensive evaluation of the burden of IHs on parents of children requiring systemic treatment in the United States and Europe. METHODS: This noninterventional cross-sectional study included infants with newly diagnosed IH requiring systemic treatment...
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318057/dermatomyofibromas-arising-in-children-report-of-two-new-cases-and-review-of-the-literature
#12
Janice E Ma, Carilyn N Wieland, Megha M Tollefson
Dermatomyofibroma is a rare, benign mesenchymal proliferation not commonly reported in children. Two patients with biopsy-proven dermatomyofibroma were identified (one female, one male) at our institution, both with rather atypical clinical presentations. The clinical and histopathologic findings and a review of the literature are presented here. Features of dermatomyofibroma should be recognized and differentiated from those of similar-appearing entities since the prognosis of this benign tumor is favorable after complete excision...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318056/cutaneous-and-systemic-findings-in-mosaic-neurofibromatosis-type-1
#13
Igor Vázquez-Osorio, Anna Duat-Rodríguez, Francisco Javier García-Martínez, Antonio Torrelo, Lucero Noguera-Morel, Angela Hernández-Martín
BACKGROUND/OBJECTIVES: Mosaic neurofibromatosis type 1 (MNF1) is a variant of neurofibromatosis type 1 (NF1) in which clinical manifestations are limited to one or several body segments. The objective was to characterize the cutaneous features and associated systemic findings in a cohort of children with MNF1. METHODS: We performed a retrospective study of 40 children diagnosed with MNF1 at the Department of Dermatology, Hospital Infantil Niño Jesús, Madrid, Spain, from January 1, 1986, to October 31, 2015...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318055/menkes-disease-mimicking-child-abuse
#14
Rebecca J Droms, Jillian F Rork, Riley McLean, Madelena Martin, Leah Belazarian, Karen Wiss
Althouygh Menkes disease has well-recognized neurologic, developmental, and cutaneous features, the initial presentation may resemble child abuse. We describe a 5-month-old boy with multiple fractures indicative of nonaccidental trauma who was ultimately diagnosed with Menkes disease. Copper deficiency leads to connective tissue abnormalities and may result in subdural hematomas, wormian bones, cervical spine defects, rib fractures, and spurring of the long bone metaphyses. Several of these findings, including fractures and subdural hematomas, may be misinterpreted as child abuse...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318054/efficacy-and-safety-of-targeted-high-intensity-medium-band-304-312-nm-ultraviolet-b-light-in-pediatric-vitiligo
#15
Da-Ke Dong, Zhan-Yan Pan, Juan Zhang, Xue-Fen Lu, Cheng Jin, Shi-Qin Tao, Li-Jia Yang
BACKGROUND/OBJECTIVES: Phototherapy is a commonly used treatment for vitiligo that has demonstrated safety and efficacy. High-intensity targeted ultraviolet B (UVB) light (304-312 nm) delivered using a phototherapy device is a useful therapeutic option because it can induce repigmentation in a short time without global exposure to radiation, but information regarding this device in children is limited. METHODS: We performed a retrospective analysis of 95 patches of vitiligo in 27 children treated using a targeted phototherapy device...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318051/atopic-dermatitis-in-israeli-adolescents-from-1998-to-2013-trends-in-time-and-association-with-migraine
#16
Rony Shreberk-Hassidim, Ayal Hassidim, Yoav Gronovich, Adam Dalal, Vered Molho-Pessach, Abraham Zlotogorski
BACKGROUND: Recent data have shown an increasing occurrence of atopic dermatitis (AD) in children and adolescents, as well as in adults. Most of the epidemiologic research on AD is limited to pediatric and youth populations and is based on self-reported questionnaires. METHODS: A nationwide, population-based, cross-sectional retrospective study of adolescents with AD was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318050/fibro-osseous-pseudotumor-of-the-digits-mimicking-pyogenic-granuloma
#17
Alba Gómez-Zubiaur, Laura Pericet-Fernández, María Dolores Vélez-Velázquez, Alicia Cabrera-Hernández, Ana Belen Piteiro-Bermejo, Sonia Beá-Ardebol, Susana Medina-Montalvo, Lidia Trasobares-Marugán
Fibro-osseous pseudotumor of the digits is a benign neoplasm that originates in the soft tissue adjacent to the short bones of the hands and feet. We present a case in a 13-year-old girl that was initially misdiagnosed as pyogenic granuloma. Familiarity with this entity and imaging and histologic studies are necessary to avoid incorrect diagnoses and aggressive surgical interventions.
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318049/kaposiform-hemangioendothelioma-presenting-as-hydrops-fetalis
#18
Elena Sobrino-Fernández, Minia Campos-Domínguez, Rebeca Gregorio-Hernández, Jorge Huerta-Aragonés, Cristina Beléndez-Bieler, Ángel Lancharro-Zapata, María Luisa Franco-Fernández, Belén Bernardo-Atienza, Manuel Sánchez-Luna
We describe the case of a 33-week preterm infant who developed nonimmune hydrops fetalis secondary to a kaposiform hemangioendothelioma (KHE). The tumor was successfully treated with vincristine, prednisone, ticlopidine, and aspirin. KHE can be an unusual cause of hydrops fetalis; in such cases, diagnosis can be challenging since generalized edema can obscure KHE.
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318041/effect-of-a-referral-only-policy-on-wait-time-for-outpatient-pediatric-dermatology-appointments
#19
Tiffany J Herd, Amy J Nopper, Kimberly A Horii
Decreasing wait time for pediatric dermatology appointments is important to patients. We retrospectively examined the effect of a referral-only policy on patient wait time for an initial appointment in an academic pediatric dermatology clinic and found a statistically significant decrease in wait time after the policy was instituted.
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28318040/clinical-and-laboratory-characteristics-of-a-tinea-capitis-outbreak-among-novice-buddhist-monks
#20
Sumanas Bunyaratavej, Charussri Leeyaphan, Chuda Rujitharanawong, Chanai Muanprasat, Lalita Matthapan
Sixty novice Buddhist monks with tinea capitis confirmed according to clinical presentation and mycological laboratory finding were included in this study. Mixed-type clinical presentation was observed in approximately half of all cases, together with scarring alopecia (95%) and superficial fungal skin infection at locations other than the scalp (43.3%). The major isolated organism was Trichophyton violaceum, and mixed-organism infection was found in 27 cases (45%). Slow-onset presentation and an extensive area of infection were significantly associated with mixed-type clinical presentation...
March 20, 2017: Pediatric Dermatology
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