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Pediatric Cardiology

L Wozniak-Mielczarek, R Sabiniewicz, M Drezek-Nojowicz, R Nowak, N Gilis-Malinowska, M Mielczarek, A Łabuc, A Waldoch, J Wierzba
Marfan syndrome (MFS) is a connective tissue disorder characterized by a broad range of clinical manifestations. Cardiovascular involvement is the most life-threatening aspect of the syndrome. Although abnormalities within the cardiovascular system in adults are well documented, there is still a paucity of data regarding manifestation of MFS in childhood. The aim of the study was to compare cardiovascular manifestation of MFS between children and adults. The study population consisted of 236 patients (144 children and 92 adults), who were referred to our department with suspicion of MFS...
November 11, 2018: Pediatric Cardiology
Luciane Alves Rocha, Liliam Cristine Rolo, Luciano Marcondes Machado Nardozza, Gabriele Tonni, Edward Araujo Júnior
The objective of this study was to determine the reference values for fetal heart functional measurements at 24 and 34 weeks of gestation and to develop Z-score equations for all measurements. A single-center, prospective, cross-sectional study with normal fetuses between 24 and 34 weeks of gestation was performed. All pregnant women underwent a comprehensive fetal Doppler echocardiogram with anatomical and functional analysis. Measurements of left and right cardiac output, combined cardiac output, mitral and tricuspid valve flow, inferior vena cava flow, and pulmonary vein flow were performed...
November 10, 2018: Pediatric Cardiology
Neha J Purkey, David M Axelrod, Doff B McElhinney, Joseph Rigdon, FeiFei Qin, Manisha Desai, Andrew Y Shin, Valerie Y Chock, Henry C Lee
The American Academy of Pediatrics classifies neonatal intensive care units (NICUs) from level I to IV based on the acuity of care each unit can provide. Birth in a higher level center is associated with lower morbidity and mortality in high-risk populations. Congenital heart disease accounts for 25-50% of infant mortality related to birth defects in the U.S., but recent data are lacking on where infants with critical congenital heart disease (CCHD) are born. We used a linked dataset from the Office of Statewide Health Planning and Development to access ICD-9 diagnosis codes for all infants born in California from 2008 to 2012...
November 10, 2018: Pediatric Cardiology
Christine A Capone, Jacqueline M Lamour, Josemiguel Lorenzo, Barbara Tria, Kenny Ye, Daphne T Hsu, Joseph Mahgerefteh
In adult heart failure (HF) patients, a higher ventricular arterial (VA) coupling ratio measured non-invasively is associated with worse HF prognosis and response to treatment. There are no data regarding the relationship of VA coupling to outcome in pediatric dilated cardiomyopathy (DCM) patients. We investigated the association of VA coupling ratio with worse outcome (mechanical circulatory support, transplant, or death) in 48 children with DCM and 97 age-gender matched controls. Mean age at presentation was 9 ± 7 years; DCM patients had a higher arterial elastance (3...
November 10, 2018: Pediatric Cardiology
Stephen J Dolgner, Bhawna Arya, Matthew P Kronman, Titus Chan
The purpose of this study was to create national estimates for the incidence of pediatric infective endocarditis (IE) in the United States and to determine if these changed after the implementation of the 2007 American Heart Association IE guidelines. It also sought to determine the effect of congenital heart disease (CHD) status on outcomes in IE. Hospital discharges with the diagnosis of IE in patients < 18 years old from the Kids' Inpatient Database were identified from the years 2000, 2003, 2006, 2009, and 2012...
November 10, 2018: Pediatric Cardiology
Scott A Pletzer, Andrew M Atz, Shahryar M Chowdhury
INTRODUCTION: Post-operative length of stay (LOS) after the arterial switch operation (ASO) is variable. The association between pre-operative non-invasive measures of ventricular function and post-operative course has not been well established. The aims of this study were to (1) evaluate the relationship between pre-operative non-invasive measures of ventricular function and post-operative LOS and (2) evaluate the change in ventricular function after ASO. METHODS: Data were reviewed in consecutive ASO patients between 2010 and 2016...
November 9, 2018: Pediatric Cardiology
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November 7, 2018: Pediatric Cardiology
Andrea Kelly, Samuel S Gidding, Rachel Walega, Claire Cochrane, Sarah Clauss, Ray R Townsend, Melissa Xanthopoulos, Mary E Pipan, Babette S Zemel, Sheela N Magge, Meryl S Cohen
Median survival in Down syndrome (DS) is 60 years, but cardiovascular disease risk and its markers such as left ventricular mass (LVM) have received limited attention. In youth, LVM is typically scaled to height2.7 as a surrogate for lean body mass (LBM), the strongest predictor of LVM, but whether this algorithm applies to DS, a condition which features short stature, is unknown. To examine the relationships of LVM and function with height, LBM, and moderate-to-vigorous physical activity(MVPA) in DS, DS youth aged 10-20 years, and age-, sex-, BMI-, race-matched nonDS controls underwent echocardiography for LVM, ejection fraction (EF), and left ventricular diastolic function (measured as E/E'); dual-energy X-ray absorptiometry (DXA)-measured LBM; accelerometry for MVPA...
November 1, 2018: Pediatric Cardiology
Meena Bolourchi, Eric S Silver, Leonardo Liberman
BACKGROUND: The clinical course of children with advanced heart block secondary to Lyme disease has not been well characterized. OBJECTIVE: To review the presentation, management, and time to resolution of heart block due to Lyme disease in previously healthy children. METHODS: An IRB approved single-center retrospective study was conducted of all patients < 21 years old with confirmed Lyme disease and advanced second or third degree heart block between 2007 and 2017...
October 31, 2018: Pediatric Cardiology
Joseph A Camarda, Angira Patel, Michael R Carr, Luciana T Young
Quantification guidelines for pediatric echocardiograms were published in 2010 establishing consensus regarding standard measurements. However, a standard protocol for performance and analysis of pediatric echocardiograms was not defined. This study aims to identify practice variations among pediatric laboratories. A survey was sent to 85 North American pediatric laboratory directors. The survey included 29 questions assessing: demographics, methods of image acquisition, parameters routinely evaluated and reported, and methods used to assess chamber sizes, valves, and ventricular function...
October 23, 2018: Pediatric Cardiology
Saad Khoshhal
Anomalous drainage of the right superior vena cava into the left atrium (LA) has been previously reported in the medical literature. We present a unique case of a child who had two superior vena cavae, a left superior vena cava that drained normally through the coronary sinus to the right atrium, and a right superior vena cava that drained anomalously to the LA.
October 23, 2018: Pediatric Cardiology
Andrew L Cheng, Abraham M Kaslow, Jay D Pruetz, Jimmy C Lu, John C Wood, Jon A Detterich
BACKGROUND: Patients with pulmonary atresia with intact ventricular septum and critical pulmonary stenosis (PAIVS/CPS) have wide variation in right ventricle (RV) size, systolic function, and diastolic function at birth. Establishment of antegrade pulmonary blood flow creates the potential for RV dilation from chronic pulmonary insufficiency. Future surgical decisions are based on RV size and function, largely supported by longitudinal studies of patients with Tetralogy of Fallot (TOF)...
October 23, 2018: Pediatric Cardiology
Justin Godown, Cary Thurm, Matt Hall, Debra A Dodd, Brian Feingold, Jonathan H Soslow, Bret A Mettler, Andrew H Smith, David W Bearl, Kurt R Schumacher
There are limited published data addressing the costs associated with pediatric heart transplantation and no studies evaluating the variation in costs across centers. We aimed to describe center variation in pediatric heart transplant costs and assess the association of transplant hospitalization costs with patient outcomes. Using a linkage between the Pediatric Health Information System and Scientific Registry of Transplant Recipients databases, hospital costs were assessed for patients (< 18 years of age) undergoing heart transplantation (2007-2016)...
October 20, 2018: Pediatric Cardiology
Abhishek Chakraborty, Cesar Mendoza, Juan Infante, Satinder K Sandhu
Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with percutaneous coronary intervention has not been described in the past. We describe a case where an 11-year-old girl with anomalous origin of the LCA from the right coronary cusp presented with near syncope...
October 20, 2018: Pediatric Cardiology
Michael D Quartermain, Kevin D Hill, David J Goldberg, Jeffrey P Jacobs, Marshall L Jacobs, Sara K Pasquali, George R Verghese, Amelia S Wallace, Ross M Ungerleider
The early postnatal course for a newborn with critical congenital heart disease (CHD) can be negatively impacted if diagnosis is delayed. Despite this, there continues to be inconsistent evidence regarding potential benefits associated with prenatal diagnosis (PND) in neonates who undergo cardiac surgery. The objective of this study was to better define the impact of a PND on pre-operative morbidity by utilizing a large clinical database. Neonates (< 30 days) undergoing heart surgery from 2010 to 2014 and entered in the Society of Thoracic Surgeons Congenital Heart Surgery Database (STS-CHSD) were included...
October 19, 2018: Pediatric Cardiology
S Tripathi, V K Ajit Kumar
BACKGROUND: Studies on dextrocardia have been limited by low numbers. Hence, it is very difficult to find the most common diagnosis in patients with dextrocardia, who are seeking medical attention in tertiary care center. AIMS AND OBJECTIVE: To identify the most common diagnostic pattern in patients with dextrocardia with different situs. METHODS: It is a retrospective study with records dating back to up to last 21 years from a major tertiary care center in south India...
October 17, 2018: Pediatric Cardiology
Rufang Zhang, Jin Gong, Shouqing Wang, Li Shen, Yewei Xie, Xiaobing Li
The aim of this study was to investigate the role of B7-H3 in prognosis of congenital heart disease (CHD) children patients. A total of 65 CHD patients within age 3-12 years who went to our hospital were included during August 2011 to December 2012. Demographic data including age, sex, weight, clinical basic information such as New York Heart Association (NYHA) class, pathological type were collected. Blood samples were collected and serum levels of B7-H3, C-reactive protein (CRP), N-Terminal Pro-Brain Natriuretic Peptide (NT-pro-BNP), and High-sensitivity Troponin T (hsTnT) were determined by enzyme-linked immunosorbent assay (ELISA)...
October 17, 2018: Pediatric Cardiology
Ari J Gartenberg, Robert H Pass, Scott Ceresnak, Lynn Nappo, Christopher M Janson
There are few data on the incidence of echocardiographic (echo) abnormalities following catheter ablation in children in the era of 3D mapping. Wide practice variation exists regarding routine post-ablation echo. We hypothesized a low incidence of clinically significant echo abnormalities following SVT ablation in otherwise healthy children. Single center data from 2009 to 2015 were reviewed; routine post-ablation echo was standard practice. Cases were categorized as utilizing fluoroscopy alone (FLUORO) or 3D mapping with a low fluoroscopic protocol (CARTO3)...
October 12, 2018: Pediatric Cardiology
R Sobhy, M Samir, G Abdelmohsen, H Ibrahim, M Y Abd El Rahman, N Abdelrahman, N Behairy, O Imam, H Hamza
Rheumatic heart disease (RHD) is a major cause of morbidity and mortality in developing countries, so early diagnosis and treatment can reduce morbidity and mortality resulting from subsequent valvular damage. The aim of this study was to detect subtle myocardial dysfunction among children with RHD with preserved left ventricular systolic function. This is a cross-sectional case-control study that was conducted on 30 children with RHD (who had valvular affection of any degree and were not in activity) compared to 23 healthy children...
October 12, 2018: Pediatric Cardiology
Bradford J Chu, Timothy Lee, John G Gilbreth, James C Nielsen, Achiau Ludomirsky, Justin T Tretter, Puneet Bhatla
Quantification of left ventricular (LV) mass by echocardiography has not been validated against the gold standard of cardiac magnetic resonance imaging (CMR) in the pediatric population. The purpose of this study was to compare LV mass by two-dimensional and conventional M-mode echocardiography versus CMR in children. Consecutive CMR studies were paired with echocardiograms and retrospectively analyzed in children age ≤ 16 years (3 days old to 16 years old). Studies performed > 3 months between modalities and single ventricle anatomy were excluded...
October 11, 2018: Pediatric Cardiology
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