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JOURNAL ARTICLE
Wendy S Darlington, Sharjeel Syed, Kristen Wroblewski, Gabrielle Lapping-Carr, Stacy Tessler Lindau, Radhika Peddinti
Little is known about the relationship between quality of life (QOL) and food insecurity (FI) among patients with sickle cell disease (SCD). We hypothesized FI is associated with lower QOL in children and young adults with SCD. Overall (N = 99), 22% screened positive for FI. Supplemental Nutrition Assistance Program (SNAP) enrollment was 50 and 71% among people from food secure and FI households, respectively. A higher FI score was correlated with lower overall QOL (r = -0.22, p = ...
April 30, 2024: Pediatric Blood & Cancer
#22
JOURNAL ARTICLE
Audra J Reiter, Lynn Huang, Brian T Craig, Andrew M Davidoff, Lindsay J Talbot, Jordan Coggins, Jasmine Smith, Jennifer H Aldrink, Katherine C Bergus, Taleen A MacArthur, Stephanie F Polites, Chloe Boehmer, Joseph Brungardt, Marcus M Malek, Hannah N Rinehardt, Zachary J Kastenberg, Cameron M Arkin, Antoine Gourmel, Nelson Piche, Marshall Wallace, Jiancong Liang, Harold N Lovvorn, Robin T Petroze, Gwendolyn Gillies, John P Marquart, Kerri Becktell, Hau D Le, Juan Favela, Barrie S Rich, Richard D Glick, Natashia M Seemann, Jacob Davidson, Claire A Wilson, Jonathan Roach, Erin G Brown, Kathleen E Doyle, Brian A Coakley, Pamela Emengo, Pamela Merola, Christa N Grant, Anuritha Tirumani, Elisabeth T Tracy, Mary E Moya-Mendez, Roshni Dasgupta, Timothy B Lautz
PURPOSE: Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non-RCR). PATIENTS AND METHODS: This retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative...
April 28, 2024: Pediatric Blood & Cancer
#23
LETTER
Wilson Y K Chan, Ng Wai Fu, Eric C H Fu, Anthony P Y Liu, Carol L S Yan, Jeffrey P W Yau, Dennis T L Ku, Pamela P W Lee, Daniel K L Cheuk, Matthew M K Shing, Godfrey C F Chan, Wing Leung
No abstract text is available yet for this article.
April 28, 2024: Pediatric Blood & Cancer
#24
LETTER
Masanaka Sugiyama, Ayumu Arakawa, Shintaro Iwata, Kayoko Tao, Nami Shirakawa, Yuko Watanabe, Miho Nakajima, Akihiko Yoshida, Keiko Ishigaki, Akira Kawai, Chitose Ogawa
No abstract text is available yet for this article.
April 28, 2024: Pediatric Blood & Cancer
#25
JOURNAL ARTICLE
Tomoo Daifu, Katsutsugu Umeda, Atsushi Yokoyama, Takeshi Yoshida, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Ko Kudo, Yoshihisa Higuchi, Junko Takita
Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG...
April 28, 2024: Pediatric Blood & Cancer
#26
JOURNAL ARTICLE
Sequoya Fitzpatrick, Lisa M Jacola, Jennifer L Harman, Victoria W Willard
PURPOSE: Infancy/toddlerhood is a period of rapid development. All infants/toddlers (0-36 months-of-age) undergoing cancer-directed treatment at one hospital are offered developmental assessments and related services. Yet, literature comparing development of infants/toddlers with brain tumors to those with non-CNS solid tumors is sparse. DESIGN AND METHODS: Developmental assessment data were abstracted from electronic health records of infants/toddlers undergoing treatment for a brain tumor (n = 36; mean age = 21...
April 28, 2024: Pediatric Blood & Cancer
#27
JOURNAL ARTICLE
Paul Bastard, Nathalie Cozic, Régis Brion, Nathalie Gaspar, Sophie Piperno-Neumann, Camille Cordero, Estelle Leculée-Thébaud, Anne Gomez-Mascard, Françoise Rédini, Antonin Marchais, Raina Ikonomova, Morgane Cleirec, Valérie Laurence, Charlotte Rigaud, Rachid Abbas, Franck Verrecchia, Laurence Brugières, Véronique Minard-Colin
BACKGROUND: Previous studies have shown that neutrophil-to-lymphocyte (NLR) ratio at diagnosis and early lymphocytes recovery on doxorubicin-based chemotherapy, may impact the outcome in patients with osteosarcoma (OST). This study aimed to evaluate the prognostic value of hemogram parameters in patients with OST treated with high-dose methotrexate and etoposide/ifosfamide (M-EI) chemotherapy. MATERIALS AND METHODS: We retrospectively analyzed the prognostic value of various hemogram parameters at diagnosis and during therapy in a large consecutive cohort of patients with OST included in the French OS2006 trial and treated with M-EI chemotherapy...
April 28, 2024: Pediatric Blood & Cancer
#28
JOURNAL ARTICLE
Neha Jain, Anne L Ryan, Gabrielle M Haeusler, Brendan J McMullan, Andrew S Moore, Adam W Bartlett, Christopher C Blyth, Rishi S Kotecha, Daniel K Yeoh, Julia E Clark
Invasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004-2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7...
April 28, 2024: Pediatric Blood & Cancer
#29
JOURNAL ARTICLE
Patricia Barker, Delia Charest Carias, Timothy Jacobs, Philip Carpiniello, Clifford Takemoto, Jay Lieberman, Elisabeth Adderson
BACKGROUND: Up to 10% of children are reported to be allergic to penicillin, but many allergy labels are unverified and may require formal testing. Inaccurate drug allergy labels are associated with a range of adverse clinical outcomes. Patients with hematological disorders may experience frequent and severe infections; those who have been incorrectly labeled penicillin allergic may benefit from allergy de-labeling (ADL) efforts to facilitate access to beta-lactam antibiotics. We developed a multidisciplinary, pharmacist-driven process that enabled non-allergist trained providers to assess and de-label penicillin allergies in a pediatric hematology center...
April 28, 2024: Pediatric Blood & Cancer
#30
JOURNAL ARTICLE
Andrea Ferrari, Daniel Orbach, Luca Bergamaschi, Reineke A Schoot, Max M van Noesel, Daniela Di Carlo, Gianni Bisogno, Rita Alaggio, Giuseppe Maria Milano, Stefano Chiaravalli, Fernando Fuccillo, Valerie Laurence, Nadege Corradini, Patrizia Gasparini, Sabina Vennarini, Sandro Pasquali, Michela Casanova
PURPOSE: Though the prognosis for pediatric patients with localised synovial sarcoma (SS) is generally good, the chances of being cured after relapse are limited. This study describes a retrospective multi-institutional series of relapsing SS patients treated at six selected European referral centers for pediatric sarcoma. PATIENTS AND METHODS: The study included 41 patients <21 years with relapsing SS, treated between 2002 and 2022. The analysis included patient's characteristics at first diagnosis, first-line treatments, clinical findings at relapse, and second-line treatment modalities...
April 28, 2024: Pediatric Blood & Cancer
#31
JOURNAL ARTICLE
Wei Zhao, Rong Wang, Man Chen
BACKGROUND: Air-leak syndrome (ALS) is considered as an independent risk factor for poor prognosis in adult patients who had received hematopoietic stem cell transplantation (HSCT), and the 5-year overall survival (OS) of ALS is less than 30%. However, the clinical features of ALS among post-transplant pediatric patients have rarely been explored. PROCEDURES: We retrospectively reviewed 2206 pediatric patients who had received an allo-HSCT between January 2013 and December 2019 at the Hebei Yanda Lu Daopei Hospital, and analyzed the role of ALS in prognosis following HSCT...
April 26, 2024: Pediatric Blood & Cancer
#32
JOURNAL ARTICLE
Lydia Businge, Marc Hagenimana, Melitah Motlhale, Aude Bardot, Biying Liu, Kathryn Anastos, Philip E Castle, Gad Murenzi, Kimilu Claire, Daniel Sabushimike, Callixte Cyuzuzo, Gallican Kubwimana, Theoneste Maniragaba, Francois Uwinkindi, Maggie Paczkowski, Isabelle Soerjomataram, Donald Maxwell Parkin
BACKGROUND: The lack of accurate population-based information on childhood cancer stage and survival in low-income countries is a barrier to improving childhood cancer outcomes. METHODS: In this study, data from the Rwanda National Cancer Registry (RNCR) were examined for children aged 0-14 diagnosed in 2013-2017 for the eight most commonly occurring childhood cancers: acute lymphoblastic leukaemia, Hodgkin lymphoma (HL), Burkitt lymphoma (BL), non-Hodgkin lymphoma excluding BL, retinoblastoma, Wilms tumour, osteosarcoma and rhabdomyosarcoma...
April 26, 2024: Pediatric Blood & Cancer
#33
JOURNAL ARTICLE
Adil Guzel, Nurdan Tacyildiz, Filiz Bakar-Ates, Derya Ozyoruk, Aybuke Celik, Handan Dincaslan, Emel Cabi Unal
OBJECTIVES: In the etiology of childhood cancers, many genetic and environmental factors play a role. One of these factors could be cigarette smoking, and the main source of tobacco smoke exposure of children is parental smoking. However, establishing a causal relationship between parental smoking and childhood cancers has proven challenging due to difficulties in accurately detecting tobacco smoke exposure METHODS: To address this issue, we used hair cotinine analysis and a questionnaire to get information about tobacco smoke exposures of pediatric cancer patients and healthy children...
April 23, 2024: Pediatric Blood & Cancer
#34
(no author information available yet)
No abstract text is available yet for this article.
April 23, 2024: Pediatric Blood & Cancer
#35
LETTER
Yuichi Kubo, Takuya Tokuhisa, Yasuhiro Okamoto, Daisuke Saito
No abstract text is available yet for this article.
April 22, 2024: Pediatric Blood & Cancer
#36
JOURNAL ARTICLE
Gihan El-Hennawy, Salma ElMenawi, Eman Nasr Said, Wael Zekri, Mohamed Zaghloul, Ahmed Mustafa Abd Elsalam, Habiba El-Fendy, Ismail Elantably
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare pediatric cancer. Most children are first diagnosed with advanced locoregional disease. Identification of patients at higher risk of treatment failure is crucial as they may benefit from more aggressive initial treatment approaches. 18 Fluorine-labeled fluoro-2-deoxyglucose positron emission tomography (18 F-FDG PET) has shown promise as a prognostic tool for predicting outcomes. METHODS: Retrospective study of pediatric patients with locally advanced undifferentiated NPC who underwent 18 F-FDG PET/CT prior to intial treatment...
April 22, 2024: Pediatric Blood & Cancer
#37
JOURNAL ARTICLE
Weiya Li, Mingyue Shi, Pan Zhou, Ying Liu, Xiaobo Liu, Xingjun Xiao, Suqiong Zuo, Yanliang Bai, Kai Sun
BACKGROUND: The outcome of extramedullary infiltration (EMI) in pediatric acute myeloid leukemia (AML) is controversial, and little is known about the implications of stem cell transplantation (SCT) and gemtuzumab ozogamicin (GO) treatment on patients with EMI. METHODS: We retrieved the clinical data of 713 pediatric patients with AML from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) dataset, and analyzed the clinical and prognostic characteristics of patients with EMI at diagnosis and relapse...
April 21, 2024: Pediatric Blood & Cancer
#38
JOURNAL ARTICLE
Pooja Soni, Bhavna Dhingra, Samendra Karkhur, Narendra K Chaudhary, Abhijit P Pakhare
BACKGROUND: Sickle cell disease (SCD) is the commonest inherited blood disorder leading to complications occurring due to vaso-occlusion including sight-threatening retinopathy. Retinopathy can be managed if diagnosed early and vision loss can be prevented. Since, very less data are available from India, hence, this study was conducted in children (7-18 years) with SCD to diagnose retinopathy by using ocular coherence tomography (OCT) in subclinical stages. METHODS: This cross sectional single-center study was performed in 7-18 years age group children with SCD without any visual symptoms...
April 21, 2024: Pediatric Blood & Cancer
#39
JOURNAL ARTICLE
Zeynep Canan Özdemir, Coşkun Yarar, Çiğdem Öztunalı, Ersin Tötret, Kürşat Bora Çarman, Özcan Bör
The complementation Q group (FANCQ) subtype of Fanconi anemia (FA) caused by the ERCC4/XPF mutation is very rare. Two siblings, aged 13 and 10 with Fanconi phenotypic features, presented with right hemiparesis and focal-onset seizures. In both cases, cranial magnetic resonance imaging (MRI) showed mass-like lesions accompanied by peripheral edema and calcification. In one case, oral steroid treatment and surgical excision were performed, while in the other case, the cranial lesion regressed just with steroid treatment and without surgery...
April 21, 2024: Pediatric Blood & Cancer
#40
JOURNAL ARTICLE
Holly B Lindsay, Michael E Scheurer, Anthony K Allam, Bryony J Lucas, Susan L McGovern, Murali Chintagumpala, Arnold C Paulino
BACKGROUND: Recent data found a correlation between lymphopenia occurring early during craniospinal radiation therapy (RT) and risk of disease recurrence in newly diagnosed childhood medulloblastoma. However, the population included patients who received chemotherapy prior to or during RT. Here, we investigate the effect of lymphopenia during RT in patients with newly diagnosed pediatric medulloblastoma who were chemotherapy-naïve. PROCEDURE: We analyzed 79 patients with newly diagnosed medulloblastoma (ages 2-21 years) treated between 1997 and 2013 with craniospinal RT...
April 21, 2024: Pediatric Blood & Cancer
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