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Pediatric Blood & Cancer

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https://www.readbyqxmd.com/read/28306217/chemotherapy-safety-standards-a-pediatric-perspective
#1
Kristin M Belderson, Amy L Billett
No abstract text is available yet for this article.
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28306215/primary-mediastinal-and-retroperitoneal-malignant-germ-cell-tumors-in-children-and-adolescents-results-of-the-tgm95-trial-a-study-of-the-french-society-of-pediatric-oncology-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-des-cancers-de-l-enfant
#2
Hélène Sudour-Bonnange, Cécile Faure-Conter, Hélène Martelli, Frederic Hameury, Brice Fresneau, Daniel Orbach, Cécile Vérité
PURPOSE: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs). METHODS: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. RESULTS: Among 239 patients, there were 16 patients with PM and 5 with RP tumors, which represent 9% of all patients, highlighting the rarity of these extragonadal locations...
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28306214/the-prognostic-value-of-early-radiographic-response-in-children-and-adolescents-with-embryonal-rhabdomyosarcoma-stage-iv-metastases-confined-to-the-lungs-a-report-from-the-cooperative-weichteilsarkom-studiengruppe-cws
#3
Monika Sparber-Sauer, Thekla von Kalle, Guido Seitz, Tobias Dantonello, Monika Scheer, Marc Münter, Joerg Fuchs, Ruth Ladenstein, Stefan S Bielack, Thomas Klingebiel, Ewa Koscielniak
BACKGROUND: Patients with metastatic rhabdomyosarcoma (RMS) have a poor prognosis apart from children with embryonal RMS whose metastases are confined to the lungs (PRME). The prognostic significance of response in patients with metastatic disease is still unknown and optimal treatment remains to be defined. METHODS: Patient-, tumor- and treatment-related factors of patients with PRME treated on multiple prospective trials of the Cooperative Weichteilsarkom Studiengruppe (CWS) (1981-2013) were analyzed with a focus on response to induction chemotherapy...
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28296163/long-term-safety-and-efficacy-of-deferasirox-in-young-pediatric-patients-with-transfusional-hemosiderosis-results-from-a-5-year-observational-study-entrust
#4
Elliott Vichinsky, Amal El-Beshlawy, Azzam Al Zoebie, Annie Kamdem, Suzanne Koussa, Thirachit Chotsampancharoen, Andreas Bruederle, Geralyn Gilotti, Jackie Han, Mohsen Elalfy
BACKGROUND: Children with red blood cell disorders may receive regular transfusions from an early age and consequently accumulate iron. Adequate iron chelation therapy can prevent organ damage and delayed growth/development. Deferasirox is indicated for treatment of pediatric patients with chronic iron overload due to transfusional hemosiderosis; however, fewer than 10% of patients in the registration studies were aged 2 to less than 6 years. PROCEDURE: Deferasirox, a once-daily oral iron chelator, was evaluated in young pediatric patients with transfusional hemosiderosis during the observational 5-year ENTRUST study...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28296130/determinants-of-quality-of-life-outcomes-for-survivors-of-pediatric-brain-tumors
#5
Maru Barrera, Eshetu G Atenafu, Fiona Schulte, Ute Bartels, Lillian Sung, Laura Janzen, Joanna Chung, Danielle Cataudella, Kelly Hancock, Amani Saleh, Douglas Strother, Dina McConnell, Andrea Downie, Juliette Hukin, Shayna Zelcer
INTRODUCTION: To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS: Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- and caregiver-proxy-reported on QOL at baseline, 2 and 8 months. At baseline, cognitive, executive function, attention and memory, medical and demographics information were attained...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28296062/bronchiectasis-following-treatment-for-high-risk-neuroblastoma-a-case-series
#6
Madeleine Adams, Heidi Traunecker, Iolo Doull, Rachel Cox
High-risk (HR) neuroblastoma remains a very challenging disease to treat and long-term cure is only possible with intensive, multimodal treatment including chemotherapy, high-dose therapy, radiotherapy, surgery, and immunotherapy. As a result, treatment-related morbidity and late effects are common in survivors. This report outlines a case series of six patients who developed a chronic productive cough following treatment for HR neuroblastoma. High-resolution computed tomography scanning confirmed the diagnosis of bronchiectasis...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28295989/pharmacokinetics-of-two-6-mercaptopurine-liquid-formulations-in-children-with-acute-lymphoblastic-leukemia
#7
Jaszianne A Tolbert, Shasha Bai, Susan M Abdel-Rahman, Keith J August, Scott J Weir, Gregory L Kearns, Kathleen A Neville
BACKGROUND: A liquid formulation of 6-mercaptopurine (6-MP) was recently approved by the Food and Drug Administration (Purixan®) based on bioavailability (BA) data from healthy adults. We examined the pharmacokinetics (PK) and BA of 6-MP in children with acute lymphoblastic leukemia (ALL) comparing a marketed tablet, two extemporaneously prepared liquid formulations, and data from the approved liquid formulation. METHODS: Twenty-two children (6-17 years) participated in a randomized two-way, crossover study of two cohorts...
March 10, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28271596/team-based-approach-to-identify-cardiac-toxicity-in-critically-ill-hematopoietic-stem-cell-transplant-recipients
#8
Christopher E Dandoy, Sonata Jodele, Zachary Paff, Russel Hirsch, Thomas D Ryan, John L Jefferies, Michelle Cash, Seth Rotz, Abigail Pate, Michael D Taylor, Javier El-Bietar, Kasiani C Myers, Gregory Wallace, Adam Nelson, Michael Grimley, Thomas Pfeiffer, Adam Lane, Stella M Davies, Ranjit S Chima
INTRODUCTION: We observed pulmonary hypertension (PH), pericardial effusions, and left ventricular systolic dysfunction (LVSD) in multiple critically ill hematopoietic stem cell transplant (HSCT) recipients. We implemented routine structured echocardiography screening for HSCT recipients admitted to the pediatric intensive care unit (PICU) using a standardized multidisciplinary process. METHODS: HSCT recipients admitted to the PICU with respiratory distress, hypoxia, shock, and complications related to transplant-associated thrombotic microangiopathy were screened on admission and every 1-2 weeks thereafter...
March 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266804/systematic-review-and-meta-analysis-of-health-related-quality-of-life-in-pediatric-cns-tumor-survivors
#9
Fiona Schulte, K Brooke Russell, Patricia Cullen, Leanne Embry, Taryn Fay-McClymont, Donna Johnston, Abby R Rosenberg, Lillian Sung
BACKGROUND: Pediatric central nervous system (CNS) tumor survivors are at high risk for numerous late effects including decreased health-related quality of life (HRQOL). Our objective was to summarize studies describing HRQOL in pediatric CNS tumor survivors and compare HRQOL outcomes in studies that included a comparison group. PROCEDURE: EMBASE, MEDLINE, and PsychINFO were used to identify relevant articles published until August, 2016. Eligible studies reported outcomes for pediatric CNS tumor survivors diagnosed before age 21, at least 5 years from diagnosis and/or 2 years off therapy and used a standardized measure of HRQOL...
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266784/ethnic-disparities-relative-to-disease-features-and-outcomes-in-children-with-acute-myeloid-leukemia
#10
M Monica Gramatges, Aditya Deshpande, Philip J Lupo, Rachel E Rau, Michele L Redell, Terzah M Horton, Michael E Scheurer, Karen R Rabin
Hispanics with acute leukemias have poorer outcomes than non-Hispanic whites (NHWs), despite an increased likelihood of favorable prognostic features. We reviewed medical records from 167 children ages 0-18 years diagnosed with de novo AML over an 18-year period at Texas Children's Cancer Center, among whom 129 self-identified as Hispanic or NHW. Although Hispanics were significantly more likely to have the favorable prognostic cytogenetic feature t(8;21) (P = 0.04), the expected survival benefit was not observed...
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266768/successful-abo-incompatible-pediatric-living-donor-liver-transplantation-in-an-infant-with-protein-c-deficiency
#11
LETTER
Yi-Ting Yeh, Hsiu-Ju Yen, Niang-Cheng Lin, Kuo-Chiang Wang, Hsin-Lin Tsai, Chinsu Liu
No abstract text is available yet for this article.
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266767/laurence-a-boxer-md-1940-2017
#12
Peter E Newburger, Valerie P Opipari
No abstract text is available yet for this article.
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266766/early-mixed-t-cell-chimerism-is-predictive-of-pediatric-aml-or-mds-relapse-after-hematopoietic-stem-cell-transplant
#13
Larisa Broglie, Irene Helenowski, Lawrence J Jennings, Kristian Schafernak, Reggie Duerst, Jennifer Schneiderman, William Tse, Morris Kletzel, Sonali Chaudhury
Patients with acute myeloid leukemia (AML) who relapse after hematopoietic stem cell transplantation (HCT) have dismal outcomes. Our ability to predict those at risk for relapse is limited. We examined chimerism trends post-HCT in 63 children who underwent HCT for AML or myelodysplastic syndrome (MDS). Mixed T-cell chimerism at engraftment and absence of chronic graft versus host disease (cGVHD) were associated with relapse (P = 0.04 and P = 0.02, respectively). Mixed T-cell chimerism at engraftment was predictive in patients without cGVHD (P = 0...
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266763/viral-the-propagation-of-a-christmas-carol-produced-by-adolescent-cancer-patients-at-the-istituto-nazionale-tumori-in-milan-italy
#14
LETTER
Andrea Ferrari, Stefano Signoroni, Matteo Silva, Paola Gaggiotti, Laura Veneroni, Carlo Alfredo Clerici, Maura Massimino
No abstract text is available yet for this article.
March 7, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266135/health-related-quality-of-life-of-children-on-treatment-for-acute-lymphoblastic-leukemia-a-systematic-review
#15
Joanna E Fardell, Janine Vetsch, T Trahair, M K Mateos, M A Grootenhuis, L M Touyz, G M Marshall, C E Wakefield
Children with acute lymphoblastic leukemia (ALL) undergo intense anticancer treatment. We systematically reviewed 22 studies evaluating 2,073 ALL patients' health-related quality of life (HRQL) and its clinical/demographic correlates during treatment. Overall HRQL was significantly reduced on treatment. Despite HRQL improvements over time, longitudinal studies reported a proportion of children continued to experience reduced HRQL after treatment completion. We found inconsistent associations between clinical/demographic factors and HRQL outcomes...
March 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28266129/household-income-and-risk-of-poverty-of-parents-of-long-term-childhood-cancer-survivors
#16
Luzius Mader, Katharina Roser, Julia Baenziger, Eva Maria Tinner, Katrin Scheinemann, Claudia Elisabeth Kuehni, Gisela Michel
BACKGROUND: Taking care of children diagnosed with cancer affects parents' professional life and may place the family at risk-of-poverty. We aimed to (i) compare the household income and risk-of-poverty of parents of childhood cancer survivors (CCS) to parents of the general population, and (ii) identify sociodemographic and cancer-related factors associated with risk-of-poverty. METHODS: As part of the Swiss Childhood Cancer Survivor Study, we sent a questionnaire to parents of CCS aged 5-15 years, who survived ≥5 years after diagnosis...
March 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28244694/global-assessment-of-cancer-incidence-and-survival-in-adolescents-and-young-adults
#17
Archie Bleyer, Andrea Ferrari, Jeremy Whelan, Ronald D Barr
In high-income countries, cancer remains the commonest cause of disease-related death in adolescents and young adults (AYAs) despite survival improvements. With more than 1,000,000 new diagnoses of cancer in AYAs annually worldwide, and their number of life-years affected by cancer being greatest of all ages, the global burden of cancer in AYAs exceeds that in all other ages. In low- and middle-income countries, where the great majority of the world's 3 billion AYAs reside, the needs of those with cancer have been identified and demand attention...
February 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28244685/pelvis-ewing-sarcoma-local-control-and-survival-in-the-modern-era
#18
Safia K Ahmed, Steven I Robinson, Carola A S Arndt, Ivy A Petersen, Michael G Haddock, Peter S Rose, Nadia N Issa Laack
PURPOSE: Local control for Ewing sarcoma (ES) has improved in modern studies. However, it is unclear if these gains have also been achieved for pelvis tumors. The purpose of this study is to evaluate local control and survival in pelvis ES patients treated in the modern era. METHODS: All pelvis ES patients diagnosed from 1990 to 2012 and seen at Mayo Clinic were identified. Factors relevant to survival and local control were analyzed. RESULTS: The cohort consisted of 48 patients...
February 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28244653/traditional-and-complementary-medicine-used-with-curative-intent-in-childhood-cancer-a-systematic-review
#19
Caroline Diorio, Kristen Salena, Elena J Ladas, Catherine G Lam, Glenn M Afungcwhi, Festus Njuguna, Stacey Marjerrison
Traditional and complementary medicine (T&CM) strategies are widely utilized in pediatric oncology, with many families reporting T&CM use with the intention to cure cancer. Study of T&CM agents presents many challenges, as a heterogeneous group of agents and techniques are used for a variety of different purpose in many different oncologic conditions. We present a systematic review of the literature examining published reports in which T&CM agents are used with an intention of cure. Twenty-two reports were identified, with most reports being of poor quality...
February 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28244643/plasma-asparaginase-activity-asparagine-concentration-and-toxicity-after-administration-of-erwinia-asparaginase-in-children-and-young-adults-with-acute-lymphoblastic-leukemia-phase-i-ii-clinical-trial-in-japan
#20
Chitose Ogawa, Fumi Taguchi, Hiroaki Goto, Katsuyoshi Koh, Daisuke Tomizawa, Akira Ohara, Atsushi Manabe
BACKGROUND: A phase I/II study of Erwinia asparaginase in Japanese children and young adults with acute lymphoblastic leukemia (ALL) was performed to investigate its activity and toxicity. PROCEDURE: Eligible patients were in remission and had developed allergy to Escherichia coli asparaginase. Erwina asparaginase was intramuscularly administrated on days 2, 5, 7, 9, 11, and 13. To measure the plasma l-asparagine concentration (PAC), amino acids were derivatized with N(α) -(5-fluoro-2,4-dinitrophenyl)-l-leucinamide...
February 28, 2017: Pediatric Blood & Cancer
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