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Pediatric Blood & Cancer

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https://www.readbyqxmd.com/read/29218844/predictors-of-hepatotoxicity-and-pancreatitis-in-children-and-adolescents-with-acute-lymphoblastic-leukemia-treated-according-to-contemporary-regimens
#1
Christopher C Denton, Yasmin A Rawlins, Matthew J Oberley, Deepa Bhojwani, Etan Orgel
BACKGROUND: Hepatotoxicity and pancreatitis are common treatment-related toxicities (TRTs) during contemporary treatment regimens for acute lymphoblastic leukemia (ALL). Limited detailed data from Children's Oncology Group (COG) regimens has been previously reported to enable identification of patient and treatment risk factors for these toxicities and their impact on outcomes. PROCEDURE: We analyzed a retrospective pediatric ALL cohort treated at a single institution according to COG regimens from 2008 to 2015...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29218835/-we-just-follow-the-patients-lead-healthcare-professional-perspectives-on-the-involvement-of-teenagers-with-cancer-in-decision-making
#2
Emma Day, Louise Jones, Richard Langner, L Caroline Stirling, Rachael Hough, Myra Bluebond-Langner
PURPOSE: We report on an in-depth interview and participant observation study that uses data from multiple sources to determine how the involvement of teenagers with leukaemia is understood and enacted in healthcare. In this article, we investigate healthcare professionals' (HCP) views of teenagers' involvement in decisions about their care and treatment for leukaemia. METHODS: We conducted participant observation at 98 multi-disciplinary meetings and 95 open-ended, semi-structured interviews and informal conversations with clinical teenage cancer teams at one UK tertiary referral centre...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29218818/loss-of-fundus-view-as-an-indication-for-secondary-enucleation-in-retinoblastoma
#3
Jesse L Berry, Kaitlin Kogachi, Rima Jubran, Jonathan W Kim
In this retrospective study, we evaluated loss of fundus view as an indication for secondary enucleation and associated histopathologic findings. Of 64 secondarily enucleated eyes, 24 were enucleated for loss of fundus view. Average time from loss of fundus view to enucleation was 4.7 months. Of these eyes, 22 had viable tumor cells on histopathology, but none had high-risk features. Loss of fundus view was a common indication for secondary enucleation after chemoreduction. Given the high prevalence of viable histopathologic tumor cells, enucleation for loss of fundus view should not be significantly delayed to decrease risk of high-risk tumor progression...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29218777/decision-making-in-pediatric-hematopoietic-cell-transplantation-influential-factors-vary-among-diseases
#4
REVIEW
Ginny L Schulz, Katherine P Kelly, Megan Holtmann, Michelle M Doering, Jane M Armer
Hematopoietic cell transplantation (HCT) is not a trivial treatment decision in pediatrics. We sought to understand what influences this decision-making process from the perspectives of the pediatric patients, their family, and physicians. Using integrative review methods, we identified 19 relevant studies: six qualitative, ten quantitative, and three mixed methods. Synthesis of the results revealed six themes describing patient, family, and provider decision-making processes with distinct subthemes contrasting influential factors among malignant and nonmalignant diseases...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29218773/illness-and-end-of-life-experiences-of-children-with-cancer-who-receive-palliative-care
#5
Erica C Kaye, Courtney A Gushue, Samantha DeMarsh, Jonathan Jerkins, April Sykes, Zhaohua Lu, Jennifer M Snaman, Lindsay Blazin, Liza-Marie Johnson, Deena R Levine, R Ray Morrison, Justin N Baker
BACKGROUND: The field of pediatric palliative oncology is newly emerging. Little is known about the characteristics and illness experiences of children with cancer who receive palliative care (PC). METHODS: A retrospective cohort study of 321 pediatric oncology patients enrolled in PC who died between 2011 and 2015 was conducted at a large academic pediatric cancer center using a comprehensive standardized data extraction tool. RESULTS: The majority of pediatric palliative oncology patients received experimental therapy (79...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29193772/efficacy-of-nivolumab-in-a-patient-with-systemic-refractory-alk-anaplastic-large-cell-lymphoma
#6
LETTER
Charlotte Rigaud, Samuel Abbou, Véronique Minard-Colin, Birgit Geoerger, Jean Yves Scoazec, Gilles Vassal, Nabaz Jaff, Laurence Heuberger, Dominique Valteau-Couanet, Laurence Brugieres
No abstract text is available yet for this article.
November 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29193588/long-term-evidence-that-a-pediatric-oncology-mentorship-program-for-young-investigators-is-feasible-and-beneficial-in-the-cooperative-group-setting-a-report-from-the-children-s-oncology-group
#7
Adam J Esbenshade, Christopher R Pierson, Amanda L Thompson, Damon Reed, Abha Gupta, Adam Levy, Lisa S Kahalley, Paul Harker-Murray, Reuven Schore, Jodi A Muscal, Leanne Embry, Kelly Maloney, Terzah Horton, Patrick Zweidler-Mckay, Girish Dhall
BACKGROUND: Mentorship of junior faculty is an integral component of career development. The Children's Oncology Group (COG) Young Investigator (YI) Committee designed a mentorship program in 2004 whose purpose was to pair YIs (faculty ≤10 years of first academic appointment) with a senior mentor to assist with career development and involvement in COG research activities. This study reports on the committee's ability to achieve these goals. PROCEDURE: An online survey was sent to YIs who were registered with the program from 2004 to2015, assessing three major domains: (1) overall experience with the mentor pairing, (2) satisfaction with the program, and (3) academic accomplishments of the mentees...
November 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29171168/pilocytic-astrocytoma-with-leptomeningeal-spread-in-a-patient-with-incontinentia-pigmenti-presenting-with-unilateral-nystagmus
#8
Cheryl B Bayart, Gisele E Ishak, Laura S Finn, Amy Lee, Francine Baran, Angela Sun, Deepti Gupta, Nicholas A Vitanza
Incontinentia pigmenti (IP) is a genetic disorder caused by mutations in IKBKG, leading to functional loss of nuclear factor kappa B (NF-ĸB). We report the case of a 6-month-old female child with IP who presented with unilateral nystagmus and was found to have a pilocytic astrocytoma with leptomeningeal spread. Enhanced understanding of the relationship between NF-ĸB, along with its upstream regulators, and tumorigenesis may shed light on whether a subset of patients with IP may be at increased risk for neoplasia...
November 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29165928/how-to-solve-the-problem-of-hypersensitivity-to-asparaginase
#9
Ching-Hon Pui, Yiwei Liu, Mary V Relling
No abstract text is available yet for this article.
November 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29165874/aml-presenting-with-a-preleukemic-episode-and-acquired-heterochromia-in-a-child-with-macrosomia
#10
LETTER
Youyang Yang, Melanie Kazlas, Medha Sharma, Alison Friedmann
No abstract text is available yet for this article.
November 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29160610/do-pregnancy-characteristics-contribute-to-rising-childhood-cancer-incidence-rates-in-the-united-states
#11
Rebecca D Kehm, Theresa L Osypuk, Jenny N Poynter, David M Vock, Logan G Spector
BACKGROUND: Since 1975, childhood cancer incidence rates have gradually increased in the United States; however, few studies have conducted analyses across time to unpack this temporal rise. The aim of this study was to test the hypothesis that increasing cancer incidence rates are due to secular trends in pregnancy characteristics that are established risk factors for childhood cancer incidence including older maternal age, higher birthweight, and lower birth order. We also considered temporal trends in sociodemographic characteristics including race/ethnicity and poverty...
November 21, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29134776/acute-chest-syndrome-among-children-hospitalized-with-vaso-occlusive-crisis-a-nationwide-study-in-the-united-states
#12
Takuto Takahashi, Yusuke Okubo, Atsuhiko Handa
PURPOSE: Acute chest syndrome (ACS) is a common complication among pediatric inpatients with sickle cell disease and vaso-occlusive crisis (VOC). However, little is known about the factors associated with ACS complication. The present study assessed the epidemiological features of children hospitalized with VOC and ascertained factors associated with ACS complication. METHODS: Hospital discharge records of patients with VOC aged <20 years were obtained for the years 2003, 2006, 2009, and 2012 from the Kids' Inpatient Database...
November 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29134758/who-is-responsible-for-delivering-palliative-care-to-children-with-cancer
#13
Abby R Rosenberg, Meaghann S Weaver, Lori Wiener
No abstract text is available yet for this article.
November 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29134750/tumor-predisposition-syndromes-the-challenge-of-de-novo-mutations
#14
LETTER
Paula Pérez-Albert, Teresa de Rojas, Laura Rey, Ángela Hernández-Martín, David Ruano, Luis Madero
No abstract text is available yet for this article.
November 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29134740/elevated-mitochondrial-dna-copy-numbers-in-pediatric-acute-lymphoblastic-leukemia-a-potential-biomarker-for-predicting-inferior-survival
#15
Ayushi Jain, Sameer Bakhshi, Himani Thakkar, Mike Gerards, Archna Singh
BACKGROUND: Studies on mitochondrial DNA copy number reveal an increase or decrease in copy number that appears to be cancer specific, but data on acute lymphoblastic leukemia have been inconsistent regarding the significance of changes in mitochondrial DNA copies. The purpose of this pilot study was to analyze mitochondrial DNA copy number and mitochondrial DNA integrity. PROCEDURE: Copy number and mitochondrial deletion ratios were estimated in the bone marrow of 51 patients and peripheral blood of 30 healthy controls using quantitative real-time PCR...
November 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115724/malignant-peripheral-nerve-sheath-tumor-the-need-to-get-it-right-first-time-around
#16
Bernadette Brennan
No abstract text is available yet for this article.
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115718/impact-of-radiation-therapy-and-extent-of-resection-for-ependymoma-in-young-children-a-population-based-study
#17
C A Snider, K Yang, S C Mack, J H Suh, S T Chao, T E Merchant, E S Murphy
BACKGROUND: Young children with posterior fossa ependymoma (PF-EPN) have a worse prognosis than older children, and they have a unique molecular profile (PF-EPN-A subtype). Alternative treatment strategies are often used in these young patients, and their prognostic factors are less clear. METHODS: We characterized the prognostic factors and treatment outcomes of 482 patients between ages 0 and 3 years with the diagnosis of ependymoma identified from the Surveillance, Epidemiology, and End Results registry (1973-2013)...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115716/long-term-results-in-children-with-head-and-neck-rhabdomyosarcoma-a-report-from-the-italian-soft-tissue-sarcoma-committee
#18
Maria Carmen Affinita, Andrea Ferrari, Giuseppe Maria Milano, Giovanni Scarzello, Francesco De Leonardis, Luca Coccoli, Roberta Pericoli, Eleonora Basso, Ilaria Zanetti, Angela Scagnellato, Gianni Bisogno
BACKGROUND: Rhabdomyosarcoma (RMS) occurring at nonparameningeal head and neck (NPM-HN) sites carries a better prognosis than parameningeal RMS and some other sites. We analyzed the treatments administered and results obtained in patients with localized NPM-HN RMS, included in the protocols coordinated by the Italian Soft Tissue Sarcoma Committee (STSC), in an effort to identify prognostic factors that could facilitate the tailoring of treatment. METHODS: Sixty-six patients up to 18 years of age with previously untreated, localized NPM-HN RMS were prospectively registered in three consecutive protocols: RMS79, RMS88, and RMS96...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115715/infusion-hemolysis-after-pediatric-major-abo-mismatched-bone-marrow-transplant-comparison-of-two-red-blood-cell-depletion-techniques
#19
Robert Sheppard Nickel, Muna Qayed, Diana Worthington-White, Sean R Stowell, Kuang-Yueh Chiang
BACKGROUND: During major ABO-mismatched bone marrow transplant (BMT), the infusion of incompatible red blood cells (RBCs) that are present in the bone marrow graft can cause adverse events from hemolysis. RBC depletion of the bone marrow graft can decrease this risk, but the optimal method to prevent hemolysis is unclear. PROCEDURE: We conducted a retrospective cohort study of patients who underwent major ABO-mismatched BMT at a pediatric center and had RBC depletion with either hydroxyethyl starch (HES) sedimentation or Ficoll density gradient separation...
November 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29115714/deep-vein-thrombosis-in-pediatric-patients
#20
REVIEW
Julie Jaffray, Guy Young
Due to advances in caring for critically ill children and those with chronic diseases, rates of deep vein thrombosis (DVT) are increasing in children. Risk factors consist of central venous catheters, chronic medical conditions, thrombophilia, and various medications. Compression Doppler ultrasonography is the method most commonly used to diagnose DVT, and patients will usually present with pain and swelling of the affected limb. Anticoagulation via subcutaneous injection is the most common treatment regime for children with DVT, and the new, direct oral anticoagulants are currently under investigation...
November 8, 2017: Pediatric Blood & Cancer
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