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Pediatric Blood & Cancer

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https://www.readbyqxmd.com/read/28224700/delivery-of-radiation-therapy-in-resource-limited-settings-a-pilot-quality-assessment-study
#1
Alexandra Power-Hays, Paola Friedrich, Gretchen Fernandez, Naly A Cruz, Karen Marcus, Carlos Rodriguez-Galindo, Luisa Collado
Progress has been made in resource-limited countries in treating acute lymphoblastic leukemia, but advances in solid malignancies have been slower. Multidisciplinary care coordination is challenging, assessing adherence to guidelines through quality improvement initiatives is essential. We characterized deviations from guidelines in the delivery of radiation in a middle-income country program as a pilot for evaluating adequacy of local control and as surrogate for integration of multidisciplinary care. One-third of patients for whom it was indicated did not receive radiation...
February 22, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205419/prevalence-of-cardiovascular-late-sequelae-in-long-term-survivors-of-childhood-cancer-a-systematic-review-and-meta-analysis
#2
Peter Scholz-Kreisel, Claudia Spix, Maria Blettner, Susan Eckerle, Jörg Faber, Philipp Wild, Hiltrud Merzenich, Ulrike Hennewig
BACKGROUND: Cardiovascular diseases are well-known late effects of childhood cancer and research on these late effects is a highly important emerging field. We conducted a systematic review with a meta-analysis to give an overview of the current evidence and the prevalence of late cardiovascular events. PROCEDURE: We included publications in which the study populations were children and adolescents who survived cancer. Outcome was defined as all cardiovascular clinical and subclinical endpoints or diagnoses appearing at least one year after cancer diagnosis...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205418/pediatric-neuroendocrine-carcinoid-tumors-management-pathology-and-imaging-findings-in-a-pediatric-referral-center
#3
Andrew J Degnan, Shannon Tocchio, Waleed Kurtom, Sameh S Tadros
BACKGROUND: While neuroendocrine (carcinoid) tumors are increasingly recognized in the adult population, they are often not suspected in children. PROCEDURE: Retrospective review of all well-differentiated neuroendocrine (carcinoid) tumors was performed based on pathology reports from a quaternary pediatric medical center between January 2003 and June 2016. Clinical presentations, treatment approaches, imaging findings, and outcomes were reviewed and analyzed. RESULTS: A total of 45 cases of pathology-proven carcinoid tumor were reported with an average age of 14...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205381/the-clinical-significance-of-equivocal-findings-on-spinal-mri-in-children-with-medulloblastoma
#4
Julie Bennett, Ramy Ashmawy, Vijay Ramaswamy, Derek Stephens, Eric Bouffet, Normand Laperriere, Michael Taylor, Manohar Shroff, Ute Bartels
BACKGROUND: Medulloblastoma (MB) is the most common malignant brain tumor of childhood, with cerebrospinal fluid spread the most common site of metastasis. Currently, children diagnosed with MB and evidence of spinal metastasis are treated with an increased dose of craniospinal radiation (CSI). This report reviewed equivocal abnormalities including nerve root clumping, linear vascular enhancement, nerve root enhancement and/or other vague findings on spinal magnetic resonance imaging (MRI) to elucidate their prognostic significance and aid in risk stratification...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205376/drug-drug-interactions-in-pediatric-oncology-patients
#5
T E Balk, I H van der Sijs, T van Gelder, J J B Janssen, I M van der Sluis, R W F van Leeuwen, F K Engels
BACKGROUND: Drug-drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic drugs in outpatient pediatric oncology patients. PROCEDURE: After informed consent and inclusion, the following information was collected: currently prescribed noncytostatic and cytostatic drugs, comorbidities, and use of over-the-counter (OTC) drugs, complementary and alternative medicines (CAMs), and dietary supplements...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205374/developmental-pharmacokinetics-of-sirolimus-implications-for-precision-dosing-in-neonates-and-infants-with-complicated-vascular-anomalies
#6
Tomoyuki Mizuno, Tsuyoshi Fukuda, Chie Emoto, Paula S Mobberley-Schuman, Adrienne M Hammill, Denise M Adams, Alexander A Vinks
BACKGROUND: Sirolimus has recently been shown to be efficacious and tolerable in pediatric patients with complicated vascular anomalies. Nevertheless, dosing information remains very limited especially for neonates and infants. The purpose of this study was to develop an age-appropriate sirolimus starting dosing regimen based on the developmental changes in drug elimination capacity using data collected in neonates and infants. PROCEDURE: A recently developed sirolimus maturation model [Emoto et al...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205365/paratesticular-rhabdomyosarcoma-in-children-and-adolescents-outcome-and-patterns-of-relapse-when-utilizing-a-nonsurgical-strategy-for-lymph-node-staging-report-from-the-international-society-of-paediatric-oncology-siop-malignant-mesenchymal-tumour-89-and-95
#7
Timothy Rogers, Veronique Minard-Colin, Nathalie Cozic, Meriel Jenney, Johannes H M Merks, Soledad Gallego, Christine Devalck, Mark N Gaze, Anna Kelsey, Odile Oberlin, Mike Stevens, Richard D Spicer, Christophe Bergeron, Helene Martelli
PURPOSE: To report the results from International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumors studies (MMT 89 and 95) of males with nonmetastatic paratesticular rhabdomyosarcoma. METHODS: From 1989 to 2003, 159 patients were included. Radical inguinal orchidectomy was recommended, but retroperitoneal lymph node (LN) assessment was based on imaging alone. The treatment was stratified by stage (SIOP tumor-node-metastasis staging system) and histology...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205329/the-unpredictable-northern-light-the-rise-and-fall-of-the-aurora-kinase-inhibitors
#8
C M Zwaan, M L Den Boer
No abstract text is available yet for this article.
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205327/early-mixed-chimerism-based-preemptive-immunotherapy-in-children-undergoing-allogeneic-hematopoietic-stem-cell-transplantation-for-acute-leukemia
#9
Biljana Horn, Justin T Wahlstrom, Alexis Melton, Angela Liou, Marie Ouachee-Chardin, Gauri Sunkersett, Jennifer Willert, Jimmy Hwang, Jueleah Expose-Spencer, Mort C Cowan, Janelle Facchino, Christopher C Dvorak
This retrospective analysis comprises 10-year experience with early posttransplant mixed chimerism-based preemptive intervention. Out of 104 patients, 51 received preemptive immunotherapy. Their outcomes were similar to patients achieving full donor chimerism spontaneously. Among patients receiving intervention, 5-year event-free survival was identical in patients with and without pretransplant residual disease, respectively (68% [95% confidence interval (CI) 38-98%] vs. 69% [95% CI 54-85%] log-rank = 0.4)...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205315/prevention-of-chemotherapy-induced-vomiting-in-children-receiving-multiple-day-cisplatin-chemotherapy-a-hospital-based-retrospective-cohort-study
#10
Kenji Kishimoto, Keiichiro Kawasaki, Atsuro Saito, Aiko Kozaki, Toshiaki Ishida, Daiichiro Hasegawa, Yoshiyuki Kosaka
BACKGROUND: Optimal prevention of chemotherapy-induced vomiting (CIV) has not been established for patients receiving cisplatin in divided doses. The aim of this study was to describe the incidence and risk factors of CIV in children who received multiple-day cisplatin chemotherapy. PROCEDURE: A total of 24 consecutive pediatric patients (age 0-19 years) who received multiple-day cisplatin chemotherapy in our hospital were enrolled. Patients with relapsed disease or primary intracranial tumor and those who received concurrent radiation therapy were excluded...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28176457/predictors-of-acupuncture-use-among-children-and-adolescents-with-cancer
#11
Sagar K Chokshi, Elena J Ladas, Katherine Taromina, Douglas McDaniel, Diane Rooney, Zhezhen Jin, Wei-Chun Hsu, Kara M Kelly
BACKGROUND: Evidence for the application of acupuncture in pediatric oncology is limited. We investigated the acceptance of acupuncture and factors associated with its use among children and adolescents with cancer. METHODS: Ninety acupuncture-naïve children receiving cancer treatment at Columbia University Medical Center (CUMC) provided consent/assent for participation. Participants could choose to receive or refuse integrative services offered at CUMC. Symptoms were collected for a 6-month period with the Memorial Symptom Assessment Scale (MSAS)...
February 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28164435/childhood-neoplasms-presenting-at-autopsy-a-20-year-experience
#12
Victoria A Bryant, John Booth, Liina Palm, Michael Ashworth, Thomas S Jacques, Neil J Sebire
OBJECTIVE: The aims of the review are to establish the number of undiagnosed neoplasms presenting at autopsy in a single centre and to determine the incidence and most common causes of sudden unexpected death due to neoplasia in infancy and childhood (SUDNIC). DESIGN: Retrospective observational study of paediatric autopsies performed on behalf of Her Majesty's Coroner over a 20-year period (1996-2015; n = 2,432). Neoplasms first diagnosed at autopsy were identified from an established database and cases meeting the criteria for sudden unexpected death were further categorised...
February 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28150396/treatment-and-outcome-of-neuroblastoma-with-intraspinal-extension-a-systematic-review
#13
Kathelijne Kraal, Thomas Blom, Max van Noesel, Leontien Kremer, Huib Caron, Godelieve Tytgat, Heleen van der Pal
We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension...
February 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28150383/evaluation-of-a-joint-adult-and-pediatric-clinic-for-cancer-survivorship-care
#14
Vicki Kam, Eleanor Hendershot, Loretta Anderson, Stacey Marjerrison
OBJECTIVES: The best model of care for long-term follow-up of survivors of childhood cancer is uncertain. We describe the care experience provided by the joint adult/pediatric AfterCare Clinic at the McMaster Children's Hospital. Secondary outcomes include an evaluation of cancer worry, self-management skills, and loss to follow-up rates. METHODS: AfterCare Clinic patients aged 19-29 years were approached for study participation between January and March 2016. Data were collected from a cross-sectional survey, consisting of the Cancer Care Experience Questionnaire (CCEQ), Cancer Worry Scale (CWS), and Self-Management Skills Scale (SMSS)...
February 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28150379/diagnostic-challenges-of-bhcg-interpretation-following-gonadectomy-in-a-patient-with-swyer-syndrome
#15
LETTER
Erin Murphy Trovillion, Michael Gottschalk, Janet M Yoon
No abstract text is available yet for this article.
February 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28150377/romiplostim-for-therapy-related-thrombocytopenia-in-pediatric-malignancies
#16
Amanda E Jacobson, Nilay Shah, Bhuvana A Setty
Therapy-related thrombocytopenia (TRT), due to chemotherapy and/or radiation therapy, is common with pediatric cancer treatments, and it can result in dose reductions and therapy delays. Romiplostim, a thrombopoietin mimetic, is efficacious as a second-line treatment for immune thrombocytopenia in children and for TRT in adult cancer patients. However, there are no data for its use for TRT in children. We report a case series of five children treated for solid tumors where romiplostim was used without adverse effects to successfully resolve and prevent therapy-limiting refractory TRT...
February 2, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28139070/pediatric-laryngeal-carcinoma-in-a-heterozygous-carrier-of-fanconi-anemia
#17
A M D'Souza, J Mark, M Demarcantonio, D Leino, R Sisson, J I Geller
A case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8-year-old female treated with laryngectomy is presented. Perinatal exposure to human papilloma virus and constitutional heterozygosity for a FANCC mutation were identified, though FANCC heterozygosity is not known to be cancer predisposing. An additional tumor-associated mutation in NOTCH1 was also identified potentially contributing to oncogenesis. This case illustrates an exceedingly rare type of cancer in the pediatric population and discusses diagnostic workup, evaluation of risk factors for head and neck cancer, and treatment options...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28139061/immunohistochemical-and-molecular-profile-of-salivary-gland-cancer-in-children
#18
Laura D Locati, Paola Collini, Martina Imbimbo, Marta Barisella, Adele Testi, Lisa F Licitra, Thomas Löning, Katharina Tiemann, Pasquale Quattrone, Emanuela Bimbatti, Stefano Chiaravalli, Michela Casanova, Elena Tamborini, Roberto Carta, Patrizia Gasparini, Marco Guzzo, Maura Massimino, Andrea Ferrari
BACKGROUND: Pediatric salivary gland carcinomas (SGCs) are very rare. They differ from the adult SGCs in terms of epidemiologic and clinical behavior, being generally limited only to selected histotypes (e.g. low-grade mucoepidermoid [LG-MEC] and acinic cell cancer [AcCC]) and characterized by very good outcome. Our aim was to investigate therapeutic targets on a series of pediatric SGCs by immunohistochemical and molecular analysis. METHODS: A retrospective analysis was performed to search for cases of pediatric SGCs in the database of the Pediatric Oncology Unit at the Istituto Nazionale Tumori and in the Pathology database at the Gerhard-Seifert-Reference-Centre...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28139029/vincristine-induced-peripheral-neuropathy-in-survivors-of-childhood-acute-lymphoblastic-leukaemia
#19
Chee Geap Tay, Vanessa Wan Mun Lee, Lai Choo Ong, Khean Jin Goh, Hany Ariffin, Choong Yi Fong
BACKGROUND: Vincristine, an essential component of childhood acute lymphoblastic leukaemia (ALL) therapeutic protocols, is associated with dose-dependent neurotoxicity, but its long-term morbidity in treated children has not been clearly elucidated. The aim of this study is to determine the prevalence of vincristine-induced peripheral neuropathy (VIPN) among Malaysian childhood ALL survivors and its impact on motor function and quality of life. PROCEDURE: Survivors of childhood ALL aged 4-18 years who had completed chemotherapy for 2 years or more were evaluated for VIPN using both the clinical Total Neuropathy Score (cTNS) and nerve conduction studies...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28130858/novel-recurrent-chromosome-anomalies-in-shwachman-diamond-syndrome
#20
Roberto Valli, Elena De Paoli, Lucia Nacci, Annalisa Frattini, Francesco Pasquali, Emanuela Maserati
BACKGROUND: Two chromosome anomalies are frequent in the bone marrow (BM) of patients with Shwachman-Diamond syndrome (SDS): an isochromosome of the long arm of chromosome 7, i(7)(q10), and an interstitial deletion of the long arm of chromosome 20, del(20)(q). These anomalies are associated with a lower risk of developing myelodysplasia (MDS) and/or acute myeloid leukemia. The chromosome anomalies may be due to an SDS-specific karyotype instability, reflected also by anomalies that are not clonal, but found in single cells in the BM or in peripheral blood (PB)...
January 28, 2017: Pediatric Blood & Cancer
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