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Pediatric Blood & Cancer

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https://www.readbyqxmd.com/read/29031010/evaluation-of-aprepitant-for-acute-chemotherapy-induced-nausea-and-vomiting-in-children-and-adolescents-with-acute-lymphoblastic-leukemia-receiving-high-dose-methotrexate
#1
Femi Felix-Ukwu, Kate Reichert, M Brooke Bernhardt, Eric S Schafer, Amanda Berger
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) negatively impacts patients' quality of life. The emetogenicity of high-dose methotrexate in children and adolescents with cancer is incompletely characterized. At our institution, a number of patients with acute lymphoblastic leukemia (ALL) have received aprepitant with courses of high-dose methotrexate after poor CINV control with prior courses. PROCEDURE: We conducted a retrospective cohort analysis on patients with ALL who received methotrexate 5 g/m(2) /dose with and without concomitant aprepitant at Texas...
October 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29031000/medication-contaminants-as-a-potential-cause-of-anaphylaxis-to-vincristine-what-about-drug-specific-antigens
#2
LETTER
Nicholas G Kounis, Ioanna Koniari, George Soufras, Emmanouil Chourdakis, Anastasios Roumeliotis, Nicholas Patsouras, George Hahalis
No abstract text is available yet for this article.
October 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988459/inconsistency-in-classifying-vascular-anomalies-what-s-in-a-name
#3
Kristy S Pahl, Kyung Kim, Casey Sams, Hortensia Alvarez, Scott V Smith, Julie Blatt
BACKGROUND: Vascular anomalies are a heterogeneous group of disorders seen in children and adults. A standard nomenclature for classification has been offered by the International Society for the Study of Vascular Anomalies. Its application is important for communication among the multiple specialties involved in the care of patients and for planning treatment, as well as for research and billing. We hypothesized that terminology still is not uniformly applied, and that this could have an impact on treatment...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988442/dramatic-response-to-nivolumab-in-xeroderma-pigmentosum-skin-tumor
#4
Fanny Chambon, Sophie Osdoit, Kelly Bagny, Anne Moro, Jacqueline Nguyen, Yves Réguerre
We report the case of a 6-year-old female with xeroderma pigmentosum (XP) who developed a nonoperable scalp tumor, treated with anti-programmed cell death protein 1 (anti-PD-1) therapy (nivolumab). She presented with a sarcomatoid carcinoma of the scalp with bone lysis as well as vascular and meningeal contact. Nivolumab was initiated because it has emerged as a promising immunotherapy. We observed a dramatic tumor response with excellent tolerance. However, while on nivolumab therapy she developed two large skin melanomas and several squamous cell carcinomas, which have been resected...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988440/immature-platelet-fraction-in-immune-thrombocytopenia-useful-in-diagnosis-but-does-it-predict-bleeding
#5
Alan D Michelson
No abstract text is available yet for this article.
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988435/triple-therapy-of-vincristine-bleomycin-and-etoposide-for-children-with-kaposi-sarcoma-results-of-a-study-in-malawian-children
#6
Marita Macken, Helen Dale, Dominic Moyo, Eunice Chakmata, Sarita Depani, Trijn Israels, Dalida Niyrenda, Simon Bailey, George Chagaluka, Elizabeth M Molyneux
BACKGROUND: Kaposi sarcoma (KS) is the most common paediatric cancer in human immunodeficiency virus (HIV) endemic countries of sub-Saharan Africa, but there is little research on management and outcomes. METHODS: Children with KS at Queen Elizabeth Central Hospital, Blantyre, Malawi treated between August 2012 and March 2015 with six courses of vincristine, bleomycin and etoposide combination chemotherapy, including antiretroviral therapy (ART) if HIV infected, were studied and outcomes compared with previously reported results...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988427/hydroxyurea-therapy-in-uk-children-with-sickle-cell-anaemia-a-single-centre-experience
#7
Kate Phillips, Laura Healy, Louise Smith, Russell Keenan
INTRODUCTION: Despite the demonstrated efficacy of hydroxyurea therapy, children with sickle cell anaemia in the UK are preferentially managed with supportive care or transfusion. Hydroxyurea is reserved for children with severe disease phenotype. This is in contrast to North America and other countries where hydroxyurea is widely used for children of all clinical phenotypes. The conservative UK practice may in part be due to concerns about toxicity, in particular marrow suppression with high doses, and growth in children...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988422/comparison-of-two-cytoreductive-regimens-for-%C3%AE-%C3%AE-t-cell-depleted-haploidentical-hsct-in-pediatric-malignancies-improved-engraftment-and-outcome-with-tbi-based-regimen
#8
Elad Jacoby, Nira Varda-Bloom, Gal Goldstein, Daphna Hutt, Chaim Churi, Helly Vernitsky, Amos Toren, Bella Bielorai
BACKGROUND: Graft manipulation using selective depletion of αβ-T cells provides a source of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) enriched in effector cells. We report our experience implementing this haplo-HSCT for high-risk malignancies in pediatric patients focusing on the conditioning regimen. PROCEDURE: We performed a retrospective study of patients who underwent T-cell receptor αβ-depleted haplo-HSCT for high-risk pediatric malignancies...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988416/comment-on-value-of-flow-cytometric-analysis-of-peripheral-blood-samples-in-children-diagnosed-with-acute-lymphoblastic-leukemia
#9
LETTER
Ryan J Summers, L Katie Metrock, Sunita Park, Scott Gillespie, Sharon Castellino, Glen Lew, Frank G Keller
No abstract text is available yet for this article.
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28988412/cognitive-outcomes-among-latino-survivors-of-childhood-acute-lymphoblastic-leukemia-and-lymphoma-a-cross-sectional-cohort-study-using-culturally-competent-performance-based-assessment
#10
Laura Bava, Alexis Johns, Kimberly Kayser, David R Freyer
BACKGROUND: This study sought to characterize cognitive outcomes among Latino survivors of childhood acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). PROCEDURE: In this cross-sectional cohort study, Latino survivors of ALL (n = 57) and LL (n = 5) aged 6-16 years were pooled and evaluated using validated measures of cognitive, academic, and behavioral function and English language proficiency. Performance was compared with norms using single-sample t-tests...
October 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960754/genetic-heterogeneity-of-uncharacterized-childhood-autoimmune-diseases-with-lymphoproliferation
#11
Masatoshi Takagi, Akihiro Hoshino, Kenichi Yoshida, Hiroo Ueno, Kohsuke Imai, Jinhua Piao, Hirokazu Kanegane, Motoi Yamashita, Tsubasa Okano, Hideki Muramatsu, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Yasuhide Hayashi, Seiji Kojima, Tomohiro Morio
Autoimmune diseases in children are rare and can be difficult to diagnose.  Single causative genes have been identified for some pediatric autoimmune diseases. Such orphan diseases may not be diagnosed properly due to the variability of patients' phenotypes. Guidelines for the diagnostic process need to be developed. Fifteen patients with uncharacterized childhood autoimmune diseases with lymphoproliferation that had negative testing for autoimmune lymphoproliferative syndrome were subjected to whole-exome sequencing to identify genes associated with these conditions...
September 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960912/dicer1-syndrome-approach-to-testing-and-management-at-a-large-pediatric-tertiary-care-center
#12
Kalene van Engelen, Anita Villani, Jonathan D Wasserman, Laura Aronoff, Mary-Louise C Greer, Marta Tijerin Bueno, Bailey Gallinger, Raymond H Kim, Ronald Grant, M Stephen Meyn, David Malkin, Harriet Druker
BACKGROUND: To expand the current knowledge of DICER1 syndrome and to propose criteria for genetic testing based on experience at a pediatric tertiary care center. PROCEDURE: This study involved a retrospective chart review of the 78 patients (47 probands and 31 family members) seen in the Cancer Genetics Program at The Hospital for Sick Children (SickKids) who were offered genetic testing for DICER1. RESULTS: Of 47 probands offered genetic testing for DICER1, 46 pursued testing: 11 (23...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960831/the-phases-of-end-of-life-care
#13
Melody J Cunningham
No abstract text is available yet for this article.
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960811/vitamin-d-deficiency-and-outcomes-in-pediatric-hematopoietic-stem-cell-transplantation
#14
Kristen Beebe, Kyrie Magee, Annmarie McNulty, Jennifer Stahlecker, Dana Salzberg, Holly Miller, Lucia Mirea, Roberta Adams, Alexander Ngwube
BACKGROUND: Pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) are frequently diagnosed with vitamin D deficiency, which may impact outcomes. OBJECTIVES: To estimate the prevalence of vitamin D deficiency and examine its association with short-term survival in pediatric HSCT patients. METHODS: Patients undergoing HSCT at Phoenix Children's Hospital were retrospectively identified. Routine serum 25-hydroxyvitamin D measurements were described prior to transplant and at 100 days and 1-year post-HSCT...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960796/microbiological-profile-and-nutritional-quality-of-a-regular-diet-compared-to-a-neutropenic-diet-in-a-pediatric-oncology-unit
#15
Juliana Elert Maia, Luciane Beitler da Cruz, Lauro José Gregianin
It has been hypothesized that a neutropenic diet has lower microbe content. Here, the microbiological and nutritional contents of regular and neutropenic diets offered to pediatric patients were analyzed. Microbiological contamination was detected in five of 36 of the food samples analyzed, yet there was no statistical differences between the diets (P = 1.00) or in their odds ratio (0.62) (95% CI = 0.05-6.35; P = 0.63). The strict neutropenic diet did have less fiber (P = 0.05) and vitamin C (P = 0...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960781/whole-lung-irradiation-in-stage-iv-wilms-tumor-patients-thyroid-dosimetry-and-outcomes
#16
Tiffany M Morgan, Hasan Danish, Ronica H Nanda, Natia Esiashvili, Lillian R Meacham
PURPOSE: To report the thyroid dosimetry and long-term follow-up of childhood cancer survivors treated with whole lung irradiation (WLI) for Wilms tumor. METHODS: Twenty-eight patients with pulmonary metastases from Wilms tumor who underwent WLI from 2000 TO 2012 at a single institution were reviewed. Radiation dose to the thyroid gland in each case was calculated. Postradiation thyroid function test (TFT) results and management of thyroid function abnormalities were extracted from the medical records...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960700/predictors-of-treatment-abandonment-for-patients-with-pediatric-cancer-at-indus-children-cancer-hospital-karachi-pakistan
#17
Durr-E-Fatima Siddiqui, Muhammad Shamvil Ashraf, Sundus Iftikhar, Asim F Belgaumi
BACKGROUND: Abandonment of treatment is one of the toughest challenges to deal with in pediatric oncology. It leads to unnecessary mortality and morbidity in patients from low- and middle-income countries. PROCEDURE: The objective of our retrospective study was to determine the prevalence and predictors for abandonment among children with cancer at our hospital in Karachi, Pakistan. We analyzed data on patients younger than 18 years, diagnosed with any malignancy between November 2014 and May 2016...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960684/wrangling-with-p-values
#18
Donna Neuberg
No abstract text is available yet for this article.
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944997/desire-for-parenthood-and-reproductive-health-knowledge-in-adolescents-and-young-adults-with-sickle-cell-disease-and-their-caregivers
#19
Leena Nahata, Nicole M Caltabellotta, Kyle Ball, Sarah H O'Brien, Susan E Creary
BACKGROUND/OBJECTIVE: Sickle cell disease (SCD) and hydroxyurea have implications for fertility and reproductive health. The goal of this study was to examine desire for parenthood and reproductive health knowledge among a cohort of adolescent and young adult (AYA) with SCD receiving hydroxyurea and their caregivers at a large pediatric academic center. METHODS: Patients with SCD were approached from September 2016 to July 2017 if they were: (1) 12-20 years old, (2) prescribed hydroxyurea for at least 6 months, (3) proficient in English, and (4) accompanied by a caregiver who was proficient in English and willing to participate...
September 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944988/evaluation-and-treatment-of-langerhans-cell-histiocytosis-patients-with-central-nervous-system-abnormalities-current-views-and-new-vistas
#20
REVIEW
E Ann Yeh, Jay Greenberg, Oussama Abla, Giulia Longoni, Eli Diamond, Michelle Hermiston, Brandon Tran, Carlos Rodriguez-Galindo, Carl E Allen, Kenneth L McClain
Central nervous system (CNS) involvement in Langerhans cell histiocytosis (LCH) can include mass lesions of the hypothalamic pituitary axis, choroid plexus, cerebrum, and cerebellum or magnetic resonance imaging (MRI) signal abnormalities of the cerebellum, pons, and basal ganglia. The term neurodegenerative (ND) CNS-LCH has been given to the MRI signal abnormalities and neurologic dysfunction, although initially patients may have no clinical symptoms. Standardized evaluations to better understand the natural history and response to therapy are needed...
September 25, 2017: Pediatric Blood & Cancer
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