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Pediatric Blood & Cancer

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https://www.readbyqxmd.com/read/30520242/outcomes-following-neonatal-portal-vein-thrombosis-a-descriptive-single-center-study-and-review-of-anticoagulant-therapy
#1
Mihir D Bhatt, Vishal Patel, Michelle L Butt, Anthony K C Chan, Bosco Paes
BACKGROUND: Neonatal portal vein thrombosis (PVT) is uncommon with potentially serious complications that may manifest in infancy and childhood. OBJECTIVE: The primary aim of our study was to describe the short-term and long-term outcomes of neonatal PVT. METHODS: A retrospective chart review was conducted from 2008 to 2016 of neonates diagnosed with PVT. A systematic review was also performed from 2000 to 2018 to evaluate anticoagulant therapy (ACT) in neonatal PVT...
December 5, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30516328/long-term-analysis-of-children-with-metastatic-neuroblastoma-treated-in-the-ensg5-randomised-clinical-trial
#2
Lucas Moreno, Sucheta J Vaidya, Dominik Schrey, C Ross Pinkerton, Ian J Lewis, Pamela R Kearns, David Machin, Andrew D J Pearson
BACKGROUND: The European Neuroblastoma Study Group 5 (ENSG5) trial showed that time-intensive "rapid" induction chemotherapy (COJEC) was superior to "standard" 3-weekly chemotherapy for children with high-risk metastatic neuroblastoma. Long-term outcomes of the ENSG5 trial were analysed. PROCEDURE: Patients with metastatic neuroblastoma aged ≥12 months were randomly assigned to "standard" or "rapid" induction, receiving the same chemotherapy drugs and doses...
December 5, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30511461/survival-after-diffuse-large-b-cell-lymphoma-among-children-adolescents-and-young-adults-in-california-2001-2014-a-population-based-study
#3
R Abrahão, R C Ribeiro, D Y Lichtensztajn, A S Rosenberg, T H M Keegan
BACKGROUND: This population-based study considered the influence of rituximab on the survival of children (0-19 years), adolescents, and young adults (AYAs, 20-39 years) with diffuse large B-cell lymphoma (DLBCL), including patients with human immunodeficiency virus (HIV) infection. METHODS: Data on 642 children and AYAs diagnosed with DLBCL during 2001-2014 were obtained from the Greater Bay Area Cancer Registry in California. Facility-level reports provided treatment details...
December 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30511453/atypical-presentation-of-a-germline-apc-mutation-in-a-child-with-supratentorial-primitive-neuroectodermal-tumor
#4
LETTER
Talita Ferreira Aguiar, Anne C Barbosa-Teixeira, Silvia Souza Costa, Suzana Ezquina, Thamiris Magalhães Gimenez, Estela Novak, Lilian Maria Cristofani, Carla Rosenberg, Vicente Odone Filho, Ana Cristina Victorino Krepischi
No abstract text is available yet for this article.
December 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30511400/ikzf1-deletion-and-co-occurrence-with-other-aberrations-in-a-child-with-chronic-myeloid-leukemia-progressing-to-acute-lymphoblastic-leukemia
#5
Claudete Esteves Klumb, Thayana da Conceição Barbosa, Gabriela Nestal de Moraes, Marcia Trindade Schramm, Mariana Emerenciano, Raquel Ciuvalschi Maia
Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a short time period. CML transformation to lymphoid blast phase (BP) is associated with copy number abnormalities, characteristic of BCR-ABL1 positive acute lymphoblastic leukemia, but not of CML in the chronic phase. Here, we present an unusual case of CML progressing to BP in a 1.6-year-old child, harboring IKZF1, PAX5, CDKN2A, and ETV6 deletions at diagnosis...
December 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30511385/epidemiology-of-invasive-fungal-infections-in-immunocompromised-children-an-australian-national-10-year-review
#6
Adam W Bartlett, Megan P Cann, Daniel K Yeoh, Anne Bernard, Anne L Ryan, Christopher C Blyth, Rishi S Kotecha, Brendan J McMullan, Andrew S Moore, Gabrielle M Haeusler, Julia E Clark
BACKGROUND: A thorough understanding of local and contemporary invasive fungal infection (IFI) epidemiology in immunocompromised children is required to provide a rationale for targeted prevention and treatment strategies. METHODS: Retrospective data over 10 years from four tertiary pediatric oncology and hematopoietic stem cell transplant (HSCT) units across Australia were analyzed to report demographic, clinical, and mycological characteristics of IFI episodes, and crude IFI prevalence in select oncology/HSCT groups...
December 4, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30488611/marked-thrombocytopenia-in-a-neonate-is-associated-with-anti-hpa-5b-anti-hla-a31-and-anti-hla-b55-antibodies
#7
Mitsuo Okubo, Eriko Nishida, Akiko Watanabe, Naoto Nishizaki, Kaoru Obinata, Fumihiro Azuma, Mika Matsuhashi, Naoko Watanabe-Okochi, Nelson Hirokazu Tsuno, Kazunori Miyake, Minoru Yamaguchi, Koyo Yoshida, Akimichi Ohsaka
Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 0.09-0.15% of live births. Severe cases account for 5-31% and the frequency of multiple kinds of alloantibodies is 6.9-9% of FNAIT. We present a case of severe FNAIT associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies, successfully treated with immunoglobulin and platelet transfusion. The anti-HLA-B55 antibody was detected in the newborn's serum, but disappeared on the 20th day, which was followed by an increase of the platelet count...
November 28, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30485640/use-of-inotuzumab-ozogamicin-in-a-child-with-down-syndrome-and-refractory-b-cell-precursor-acute-lymphoblastic-leukemia
#8
LETTER
Laura Murillo, José Luis Dapena, Pablo Velasco, Cristina Díaz de Heredia
No abstract text is available yet for this article.
November 28, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30484948/ketogenic-diet-treatment-in-recurrent-diffuse-intrinsic-pontine-glioma-in-children-a-safety-and-feasibility-study
#9
Elles J T M van der Louw, Roel E Reddingius, Joanne F Olieman, Rinze F Neuteboom, Coriene E Catsman-Berrevoets
BACKGROUND: The mean overall survival rate of children with diffuse intrinsic pontine glioma (DIPG) is 9-11 months, with current standard treatment with fractionated radiotherapy and adjuvant chemotherapy. So far, novel therapeutic strategies have not yet resulted in significantly better survival. The main source of energy for glioblastoma cells is glucose. Therefore, metabolic alterations induced by the use of the extremely carbohydrate-restricted ketogenic diet (KD) as adjuvant therapy are subject of interest in cancer research...
November 28, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30479064/the-challenge-of-defining-ultra-high-risk-neuroblastoma
#10
REVIEW
Daniel A Morgenstern, Rochelle Bagatell, Susan L Cohn, Michael D Hogarty, John M Maris, Lucas Moreno, Julie R Park, Andrew D Pearson, Gudrun Schleiermacher, Dominique Valteau-Couanet, Wendy B London, Meredith S Irwin
Given the biological and clinical heterogeneity of neuroblastoma, risk stratification is vital to determining appropriate treatment. Historically, most patients with high-risk neuroblastoma (HR-NBL) have been treated uniformly without further stratification. Attempts have been made to identify factors that can be used to risk stratify these patients and to characterize an "ultra-high-risk" (UHR) subpopulation with particularly poor outcome. However, among published data, there is a lack of consensus in the definition of the UHR population and heterogeneity in the endpoints and statistical methods used...
November 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30479033/patients-with-alps-like-phenotype-diagnosed-with-immune-dysregulation-due-to-lrba-deficiency
#11
LETTER
Karen S Fernández, Reuben Antony, Ashish Kumar
No abstract text is available yet for this article.
November 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30478977/outcomes-of-observation-without-empiric-intravenous-antibiotics-in-febrile-nonneutropenic-pediatric-oncology-patients
#12
Natalie Wu, William Muller, Elaine Morgan
There are no consensus guidelines for management of pediatric oncology patients presenting with fever and nonneutropenia, with limited research into the outcomes of withholding empiric i.v. antibiotics. We conducted a prospective cohort study assessing the safety and efficacy of observing well-appearing patients presenting with fever and nonneutropenia (absolute neutrophil count ≥ 500 cells/mm3 ). Of 238 episodes, 82.7% patients were observed with no infectious complications and low overall incidence of bacteremia (3...
November 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30478948/novel-mutation-of-the-tinf2-gene-resulting-in-severe-phenotypic-revesz-syndrome
#13
LETTER
Anusak Sakwit, Duangnate Rojanaporn, Pimsiri Mekjaruskul, Wiboon Suriyajakryuththana, Werasak Sasanakul, Nongnuch Sirachainan
No abstract text is available yet for this article.
November 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30478894/pediatric-cancer-care-can-be-complicated-by-language-barriers-a-case-involving-parents-with-limited-japanese-proficiency
#14
LETTER
Kumiko Chino, Yuya Sasaki, Naoyuki Miyagawa, Bryn Meredith, Kara-Marie Delaney, Hiroaki Goto, Frances Rosario
No abstract text is available yet for this article.
November 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426675/hydroxyurea-for-primary-stroke-prevention-the-time-draweth-nigh
#15
Marvin E Reid
No abstract text is available yet for this article.
November 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426671/only-strongly-enhanced-residual-fdg-uptake-in-early-response-pet-deauville-5-or-qpet-%C3%A2-2-is-prognostic-in-pediatric-hodgkin-lymphoma-results-of-the-gpoh-hd2002-trial
#16
L Kurch, D Hasenclever, R Kluge, T Georgi, L Tchavdarova, M Golombeck, O Sabri, A Eggert, W Brenner, K W Sykora, F M Bengel, C Rossig, D Körholz, M Schäfers, T Feuchtinger, P Bartenstein, R A Ammann, T Krause, C Urban, R Aigner, S Gattenlöhner, W Klapper, C Mauz-Körholz
PURPOSE: In 2014, we published the qPET method to quantify fluorodeoxyglucose positron emission tomography (FDG-PET) responses. Analysis of the distribution of the quantified signals suggested that a clearly abnormal FDG-PET response corresponds to a visual Deauville score (vDS) of 5 and high qPET values ≥ 2. Evaluation in long-term outcome data is still pending. Therefore, we analyzed progression-free survival (PFS) by early FDG-PET response in a subset of the GPOH-HD2002 trial for pediatric Hodgkin lymphoma (PHL)...
November 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426667/using-the-patient-reported-outcomes-measurement-information-system-promis-to-measure-symptom-burden-reported-by-patients-with-brain-tumors
#17
Jin-Shei Lai, Mary Jo Kupst, Jennifer L Beaumont, Peter E Manley, John Han-Chih Chang, William F Hartsell, Young Kwok, Allison Piazza Fisher, Stewart Goldman
BACKGROUND: Children with brain tumors can experience symptom burden throughout their disease continuum. The aim of the study was to evaluate symptom burden reported by children with brain tumors and factors that potentially were associated with their symptoms. METHODS: Data from 199 children with brain tumors aged 7-22 (mean age = 14 years; 52% males; 76% white) were analyzed. Symptom burden was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) via computerized adaptive testing (CAT)-anxiety, depression, fatigue, mobility, upper extremity function, peer relationship, and cognition...
November 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426663/social-adjustment-of-adolescent-cancer-patients-transitioning-off-active-treatment-a-short-term-prospective-mixed-methods-study
#18
Sherilynn F Chan, Jennifer A Hoag, Jeffrey S Karst, Kristin M Bingen
BACKGROUND: Psychosocial follow-up in survivorship is a standard of care in pediatric oncology; however, little is known about patients' psychosocial functioning during the transition off active treatment, a unique time in the cancer journey. This study examined the social adjustment of adolescent cancer patients during this transition period, which has been understudied to date. PROCEDURE: Participants were 21 patients (ages 12-18 years; age M = 14.71 years; 62% female, 81% White) with various cancer diagnoses...
November 14, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426714/intravenous-fosaprepitant-for-the-prevention-of-chemotherapy-induced-vomiting-in-children-a-double-blind-placebo-controlled-phase-iii-randomized-trial
#19
Venkatraman Radhakrishnan, Archit Joshi, Jaikumar Ramamoorthy, Swaminathan Rajaraman, Prasanth Ganesan, Trivadi S Ganesan, Manikandan Dhanushkodi, Tenali G Sagar
BACKGROUND: Fosaprepitant is a neurokinin-1 receptor antagonist, approved for the prevention of chemotherapy-induced nausea and vomiting. The data on the use of fosaprepitant in children are limited and therefore we conducted a phase III randomized controlled trial. PROCEDURE: Children aged 1-12 years scheduled to receive moderately or highly emetogenic chemotherapy were randomly assigned to arm-A (fosaprepitant) or arm-B (placebo). Children recruited to arm-A received intravenous ondansetron plus dexamethasone followed by fosaprepitant infusion...
November 13, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30421578/treatment-and-outcome-of-patients-with-thoracic-tumors-of-the-ewing-sarcoma-family-a-report-from-the-cooperative-weichteilsarkom-studiengruppe-cws-81-86-91-96-and-2002p-trials
#20
Guido Seitz, Cristian Urla, Monika Sparber-Sauer, Andreas Schuck, Christian Vokuhl, Bernd Blank, Thomas Klingebiel, Bernarda Kazanowska, Jörg Fuchs, Ewa Koscielniak
BACKGROUND: Ewing tumors are the most frequent malignant tumors of the chest wall in children and young adults. Surgical management of these tumors can be challenging. Optimal local control remains controversial. The aim of this study was to analyze treatment, outcome, and surgical procedures in patients with thoracic tumors of the Ewing sarcoma family (TES) treated within four Cooperative Soft-Tissue Sarcoma (CWS) trials and one registry. PATIENTS AND METHODS: Sixty-two patients from 0 to 21 years treated between 1981 and 2014 were selected for this analysis...
November 12, 2018: Pediatric Blood & Cancer
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