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Pediatric Blood & Cancer

John A Kalapurakal, Mahesh Gopalakrishnan, Matthew Mille, Irene Helenowski, Susan Peterson, Cynthia Rigsby, Fran Laurie, Jae Won Jung, Thomas J Fitzgerald, Choonsik Lee
PURPOSE: This pilot study was done to determine the feasibility and accuracy of University of Florida/National Cancer Institute (UF/NCI) phantoms and Monte Carlo (MC) retrospective dosimetry and had two aims: (1) to determine the anatomic accuracy of UF/NCI phantoms by comparing 3D organ doses in National Wilms Tumor Study (NWTS) patient-matched UF/NCI phantoms to organ doses in corresponding patient-matched CT scans and (2) to compare infield and out-of-field organ dosimetry using two dosimetry methods-standard radiation therapy (RT) treatment planning systems (TPS) and MC dosimetry in these two anatomic models...
August 12, 2018: Pediatric Blood & Cancer
Kaduveettil Gopinathan Gopakumar, Shwetha Seetharam, Jagathnath Krishna Km, Manjusha Nair, Binitha Rajeswari, Guruprasad Cs, Prasanth Vr, Priyakumari Thankamony
BACKGROUND: Data from low- and middle-income countries on tumor lysis syndrome (TLS) in the pediatric population are limited. This study aims to analyze the clinical and biochemical characteristics and treatment outcomes of TLS in children with leukemia/lymphomas in a resource-limited setting. PROCEDURE: Children with intermediate risk (IRD) and high risk (HRD) for developing TLS were retrospectively studied at a tertiary cancer center in India. RESULTS: Over a three-year period, 224 children with acute leukemia/lymphoma having IRD (21...
August 12, 2018: Pediatric Blood & Cancer
Sarah L Grimshaw, Nicholas F Taylor, Francoise Mechinaud, Nora Shields
BACKGROUND: Appropriate selection of robust assessment tools is essential to monitor physical function in children with cancer during and after treatment. This systematic review aims to identify and critically appraise the measurement properties of physical function measures currently used for children with cancer. PROCEDURE: Two systematic searches of seven electronic databases [Cumulative Index to Nursing and Allied Health Literature (CINHAL), Medline, PubMed, PsychINFO, Sportsdiscus, EMBASE, and Allied and Complementary Medicine Database (AMED)] were completed to identify physical function measures used in children with cancer and to evaluate their measurement properties...
August 9, 2018: Pediatric Blood & Cancer
Nuria B Zurro, José A Tavares de Albuquerque, Tábata T França, Paola Vendramini, Christina Arslanian, Fabiola Tavares-Scancetti, Antonio Condino-Neto
No abstract text is available yet for this article.
August 9, 2018: Pediatric Blood & Cancer
Alexander Sturm, Thomas Stauch, Paul-Gerhardt Schlegel, Verena Wiegering
No abstract text is available yet for this article.
August 9, 2018: Pediatric Blood & Cancer
Liron Grossmann, Priscila Badia Alonso, Adam Nelson, Javier El-Bietar, Kasiani C Myers, Adam Lane, Heidi Andersen, David Haslam, Sonata Jodele, Stella M Davies, Christopher E Dandoy
Bacterial bloodstream infections (BSIs) are associated with poor outcomes following stem cell transplantation (SCT). We describe the demographics, treatment, complications, and outcome of 23 pediatric SCT recipients who developed three or more BSIs in the first year after SCT at our center from 2011 through 2016. The majority underwent allogeneic SCT (n = 22/23;96%), mainly from an unrelated donor (n = 19/22,86%); developed grade 2-4 graft versus host disease (GVHD; n = 14/23, 61%), all steroid refractory; and were diagnosed with thrombotic microangiopathy (n = 21/23, 91%)...
August 9, 2018: Pediatric Blood & Cancer
Melissa E Day, Mark Rodeghier, Michael R DeBaun
BACKGROUND: Based on the presumed clinical similarity between the two most severe sickle cell disease (SCD) genotypes, hemoglobin (Hb) Sβ0 thalassemia and HbSS, randomized controlled trials (RCTs) have included both genotypes. Our group has demonstrated that healthcare providers inadequately distinguish the two diagnoses through clinical and laboratory parameters. PROCEDURE: In a retrospective cohort study utilizing data from the Silent Cerebral Infarct Transfusion trial (NCT00072761), we tested the hypothesis that children with genotypic diagnoses of HbSβ0 thalassemia, when compared to HbSS, have significantly different rates of SCD comorbidities...
August 9, 2018: Pediatric Blood & Cancer
T N Gibson, S Beeput, J Gaspard, C George, D Gibson, N Jackson, V Leandre-Broome, N Palmer-Mitchell, C Alexis, J Bird-Compton, C Bodkyn, R Boyle, S McLean-Salmon, M Reece-Mills, C Sin Quee-Brown, U Allen, S Weitzman, V Blanchette, S Gupta
BACKGROUND: English-speaking Caribbean (ESC) childhood cancer outcomes are unknown. PROCEDURE: Through the SickKids-Caribbean Initiative (SCI), we established a multicenter childhood cancer database across seven centers in six ESC countries. Data managers entered patient demographics, disease, treatment, and outcome data. Data collection commenced in 2013, with retrospective collection to 2011 and subsequent prospective collection. RESULTS: A total of 367 children were diagnosed between 2011 and 2015 with a median age of 5...
August 9, 2018: Pediatric Blood & Cancer
Lisa B Kenney, Bethany Ames, Alexis L Michaud, David N Williams, Peter E Manley, Nicole J Ullrich
BACKGROUND: Evidence is not available to guide management of childhood cancer survivors (CCS) at risk for radiation-associated cerebral vascular disease (CVD) and stroke. We propose to use a consensus-based methodology to describe the collective opinion of regional experts for the care of these patients and identify areas of controversy. PROCEDURE: Thirty physicians from the New England region who care for CCS participated in a Delphi panel querying their management approach (imaging, laboratory tests, medications, counseling, referrals) to a CCS treated with cranial radiation formatted as five clinical scenarios (asymptomatic, small- and large-vessel CVD, transient ischemia, stroke) in three rounds of anonymous questionnaires...
August 9, 2018: Pediatric Blood & Cancer
Allison L Bartlett, Nancy D Leslie, Anita Gupta, James I Geller
Ornithine transcarbamylase deficiency (OTCD) disrupts the metabolic pathway responsible for converting nitrogenous waste to urea, allowing for excretion. When impaired, ammonia levels accumulate in the blood resulting in severe, sometimes life-threatening toxicities. Abnormalities of the urea cycle are often inherited, though there are some rarer acquired forms. We describe two cases of acquired OTCD in pediatric patients with fibrolamellar hepatocellular carcinoma (FL-HCC). We detail its presentation and management, explore potential underlying pathophysiology, and propose a practice change to optimize care of FL-HCC patients...
August 9, 2018: Pediatric Blood & Cancer
Samantha Knight, Lisa VanHouwelingen, David Cervi, Michael R Clay, Mark Corkins, Stacy Hines-Dowell, Kayla V Hamilton, Roya Mostafavi, Jewell Ward, Wayne L Furman, Andrew Jackson Murphy
No abstract text is available yet for this article.
August 7, 2018: Pediatric Blood & Cancer
Benjamin Sturgess, Morven Brown, Faye Fraser, Simon Bailey
BACKGROUND: Optic pathway gliomas (OPGs) are low-grade tumours of the visual pathway. Although survival rates are high, there is considerable morbidity and hence treatment focuses on preservation of vison and quality of life. The multiple, complex issues faced by these patients are often confounded by a concurrent diagnosis of neurofibromatosis type-1 (NF1). As there is a paucity of literature addressing the current practices of the multi-professional team (MPT) caring for children diagnosed with an OPG, individual professional experiences often guide the MPT's approach to the care of these children and their families...
August 7, 2018: Pediatric Blood & Cancer
Annélie S Anestin, Sarah Lippé, Philippe Robaey, Laurence Bertout, Simon Drouin, Maja Krajinovic, Bruno Michon, Émélie Rondeau, Mariia Samoilenko, Caroline Laverdière, Daniel Sinnett, Serge Sultan
BACKGROUND: Recent research has suggested that long-term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes to psychological risk and which domains are most important. The aim of this study was to systematically explore which functional domain could explain anxiety, depression, and distress symptoms. PROCEDURE: We used data available for 105 adolescents and 182 adults successfully treated for childhood acute lymphoblastic leukemia at two Canadian sites part of the PETALE cohort...
August 7, 2018: Pediatric Blood & Cancer
Hajime Uchida, Seisuke Sakamoto, Kengo Sasaki, Masahiro Takeda, Yoshihiro Hirata, Akinari Fukuda, Tomoro Hishiki, Rie Irie, Atsuko Nakazawa, Osamu Miyazaki, Shunsuke Nosaka, Mureo Kasahara
BACKGROUND: Excellent outcomes of the extreme procedure of liver resection (LR) for advanced hepatoblastoma (HB) have been achieved in recent reports. However, liver transplantation (LT) remains the only surgical treatment for patients with unresectable HB. The aim of this study was to evaluate our retrospective data for cases of advanced HB necessitating surgical intervention and analyze the prognostic factors of recurrence by comparing patients with tumors resected by LR and LT. PATIENTS AND METHODS: We retrospectively reviewed 24 children with PRETEXT II/III/IV tumors that required consideration for LT between August 2011 and September 2016...
August 7, 2018: Pediatric Blood & Cancer
Sarah A Hall, Emily Riehm Meier, Sweta Gupta, Charles Nakar, Angeli Rampersad, Nihal Bakeer, Brandon Hardesty, Manjusha Kumar
We present five patients with coexistent von Willebrand disease (VWD) and Ehlers-Danlos syndrome and 21 with VWD and joint hypermobility. Females outnumbered males ten to three, Beighton scores were documented in 58% (15 of 26 patients), and several patients experienced moderately severe bleeding. We believe coexistent hypermobility disorder with VWD potentially affects bleeding severity and want to raise awareness among hematologists. Evaluation by geneticists is recommended because of the varying complexities observed across the disease spectrum, and the availability of new genetic tests should lead to more accurate diagnoses for the various hypermobility disorders...
August 7, 2018: Pediatric Blood & Cancer
Justus Kreyer, Andreas Ranft, Beate Timmermann, Heribert Juergens, Susanne Jung, Karsten Wiebe, Tobias Boelling, Andreas Schuck, Volker Vieth, Arne Streitbuerger, Jendrik Hardes, Melina Heinemann, Uta Dirksen
BACKGROUND: The Interdisciplinary Tumor Board (ITB) of the Cooperative Ewing Sarcoma Study (CESS) Group was investigated to assess its impact on the overall survival (OAS) of Ewing sarcoma (EwS) patients. The ITB functions as a reference center for the international institutions participating in the clinical trials of the CESS group, but is also available internationally to patients who have not been treated within an appropriate clinical trial. The value of tumor boards in terms of benefit for the patients and the health care system in general is not well documented and is also the subject of controversial discussions...
August 7, 2018: Pediatric Blood & Cancer
Hidemitsu Kurosawa, Akihiko Tanizawa, Hideki Muramatsu, Chikako Tono, Akihiro Watanabe, Haruko Shima, Masaki Ito, Yuki Yuza, Kazuko Hamamoto, Noriko Hotta, Masahiko Okada, Akiko Moriya Saito, Atsushi Manabe, Shuki Mizutani, Souichi Adachi, Keizo Horibe, Eiichi Ishii, Hiroyuki Shimada
BACKGROUND: The details of the sequential use of imatinib for first-line treatment followed by second-generation tyrosine kinase inhibitors (2G-TKIs) for pediatric chronic myeloid leukemia (CML) are still unknown. This study analyzed clinical responses and adverse effects of the use of 2G-TKIs following imatinib in pediatric chronic phase (CP)-CML. PROCEDURES: The Japanese Pediatric Leukemia/Lymphoma Study Group conducted a retrospective study of patients with newly diagnosed CML from 1996 to 2011...
August 7, 2018: Pediatric Blood & Cancer
Maximilian Heeg, Sandra Ammann, Christian Klemann, Marcus Panning, Valeria Falcone, Harmut Hengel, Kai Lehmberg, Udo Zur Stadt, Katharina Wustrau, Gritta Janka, Stephan Ehl
In this report, we evaluate the hypothesis that hemophagocytic lymphohistiocytosis in patients with defects of lymphocyte cytotoxicity is usually triggered by infections. We show that in the majority of patients, extensive virus PCR panels performed in addition to routine microbiological investigations remain negative and summarize 25 patients with onset of hemophagocytic lymphohistiocytosis in utero or within the first 10 days of life, in none of which an associated bacterial or viral infection was reported...
August 1, 2018: Pediatric Blood & Cancer
Krishnaveni Sirigaddi, Inmaculada Aban, Amelia Jantz, Brandi M Pernell, Lee M Hilliard, Smita Bhatia, Jeffrey D Lebensburger
BACKGROUND: Limited evidence exists to create institutional admission criteria guidelines for febrile sickle cell patients. In addition, evidence is lacking to understand readmission rates for febrile sickle cell patients discharged from the emergency department (ED) or hospital. PROCEDURES: We conducted a 16-year retrospective study of bacteremia outcomes for febrile sickle cell patients. Risk variables analyzed included fever (either ≥ 39.5°C or ≥40°C), abnormal white blood cell (WBC) (>30,000 or <5,000/mcL), tachycardia and hypotension, or "ill appearing...
August 1, 2018: Pediatric Blood & Cancer
Jamie Cashell, Gayle M Smink, Klaus Helm, Frederico Xavier
A full-term newborn with kaposiform hemangioendothelioma (KHE) affecting the right thigh with thrombocytopenia due to Kasabach-Merritt phenomenon (KMP) was referred to our center. After biopsy, he rapidly evolved to severe thrombocytopenia and severe coagulopathy. Standard therapy was initiated with prednisolone and vincristine. His coagulopathy worsened to life-threatening hemorrhage necessitating aggressive blood products replacement. Sirolimus was added; he became transfusion independent with no further bleeding and reduction in tumor size...
August 1, 2018: Pediatric Blood & Cancer
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