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Pediatric Blood & Cancer

Manisha Agarwal, Sameer Bakhshi, Sadanand N Dwivedi, Madhulika Kabra, Rashmi Shukla, Rachna Seth
BACKGROUND: Cyclin dependent kinase inhibitor 2A/B (CDKN2A/B) genes are implicated in many malignancies including acute lymphoblastic leukemia (ALL). These tumor suppressor genes, with a key regulatory role in cell cycle are located on chromosome 9p21.3. Previous studies involving CDKN2A/B gene deletions have shown mixed associations with survival outcome in childhood ALL. PROCEDURE: Hundred and four newly diagnosed children with ALL (1-14 years) were enrolled in this study...
February 15, 2018: Pediatric Blood & Cancer
Hendrikus J Dubbink, Iris H I M Hollink, Carolina Avenca Valente, Wenhui Wang, Pengyu Liu, Michail Doukas, Max M van Noesel, Winand N M Dinjens, Anja Wagner, Ron Smits
BACKGROUND: The Wnt/β-catenin pathway plays a central role in the pathogenesis of most hepatoblastomas (HBs), that is, up to 60-80% carry activating CTNNB1 mutations. HBs can however also be the first manifestation of familial adenomatous polyposis (FAP). As this is a severe disease, it is important for the patient and related family members to firmly exclude FAP at an early stage. Current diagnosis largely depends on APC germline mutation detection on genomic DNA, which is associated with 10-20% false-negative results...
February 15, 2018: Pediatric Blood & Cancer
Joana M Mack, Gresham T Richter, David Becton, Omar Salem, Sarah E M Hill, Shelley E Crary
BACKGROUND: Vascular malformations (VM) are congenital lesions that can be debilitating and cause significant aesthetic and functional limitations. The chemotherapeutic agent bleomycin has been utilized as a sclerosant, directly injected percutaneously into the VM. Unfortunately, little is known about the benefits and short-term side effects of bleomycin with intralesional injections. PROCEDURE: An IRB approved, retrospective chart review was performed on patients with VM who had been treated with intralesional bleomycin...
February 12, 2018: Pediatric Blood & Cancer
Liliana Vasquez, Rosdali Diaz, Sharon Chavez, Fanny Tarrillo, Ivan Maza, Eddy Hernandez, Monica Oscanoa, Juan García, Jenny Geronimo, Nuria Rossell
BACKGROUND: Abandonment of treatment is a major cause of treatment failure and poor survival in children with cancer in low- and middle-income countries. The incidence of treatment abandonment in Peru has not been reported. The aim of this study was to examine the prevalence of and factors associated with treatment abandonment by pediatric patients with solid tumors in Peru. METHODS: We retrospectively reviewed the sociodemographic and clinical data of children referred between January 2012 and December 2014 to the two main tertiary centers for childhood cancer in Peru...
February 12, 2018: Pediatric Blood & Cancer
Vibhuti Agarwal, Natalie Logie, Christopher G Morris, Julie A Bradley, Ronny L Rotondo, Scott M Bradfield, Daniel J Indelicato
BACKGROUND: Ewing sarcoma of the thoracic spine and chest wall is frequently treated with concurrent chemotherapy and radiation therapy (RT). Treatment-related acute esophagitis can lead to hospitalization and treatment delays. The aim of this study was to analyze the incidence, risk factors, and management of esophagitis in pediatric patients with Ewing sarcoma of the thoracic region. METHODS: We conducted a single-institution retrospective review of patients treated over a 10-year period...
February 12, 2018: Pediatric Blood & Cancer
Courtney D Thornburg, Russell E Ware
Sickle cell disease (SCD) is an inherited red blood cell disorder that occurs worldwide and results in significant morbidity and mortality. In addition to affected children who are born in the US, an increasing number of children with SCD are migrating to the US with their families or through international adoption. Children arriving as immigrants or refugees have unique medical and psychosocial challenges that require a multidisciplinary team approach which takes into account the family's primary language, culture, and health beliefs...
February 8, 2018: Pediatric Blood & Cancer
Jennifer L McNeer, Archie Bleyer
Compared to younger and older age groups, the incidence of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) has increased more in the adolescent and young adult (AYA) population, the cause of which is unknown. As of the last decade, only half of the AYA patients with these diseases were surviving 10 years. Strong evidence exists that favors "pediatric" treatment regimens for AYAs compared to "adult" treatment regimens in terms of survival rates, hospitalization time, toxicities, late effects, and quality of life both during and after treatment...
February 8, 2018: Pediatric Blood & Cancer
Todd Dalberg, Neil L McNinch, Sarah Friebert
OBJECTIVES: The goal of this study was to assess pediatric oncology providers' perceptions of palliative care in order to validate previously identified barriers and facilitators to early integration of a pediatric palliative care team (PCT) in the care of children with cancer. METHODS: A 36-question survey based on preliminary, single-institution data was electronically distributed to pediatric oncology physicians, nurse practitioners, nurses, and social workers nationally...
February 8, 2018: Pediatric Blood & Cancer
Yangyang Ma, Jicui Zheng, Jiayan Feng, Haitao Zhu, Xianmin Xiao, Lian Chen
PURPOSE: Ectopic nephrogenic rests (ENR) are extremely rare, and their diagnosis and treatment have not yet been standardized. Our study aimed to analyze the clinical and pathological features of ENR in children and explore the optimal methods for diagnosis and treatment. METHODS: A retrospective, single-center, case series study of 13 children with ENR was performed. Clinical manifestations, work-up, pathological features, and treatment methods were analyzed, and the postoperative status was evaluated at follow-up...
February 8, 2018: Pediatric Blood & Cancer
Karolina Nemes, Nathalie Clément, Denis Kachanov, Susanne Bens, Martin Hasselblatt, Beate Timmermann, Reinhard Schneppenheim, Joachim Gerss, Reiner Siebert, Rhoikos Furtwängler, Franck Bourdeaut, Michael Christoph Frühwald
BACKGROUND: Congenital rhabdoid tumors are rare and highly aggressive malignancies. In general, patients are considered to be incurable and are often treated using an exclusive, primarily palliative approach. METHODS: A prospective and retrospective collection of 42 patients from the European Rhabdoid Registry (EU-RHAB), France and Moscow (2006-2016) diagnosed within the first 28 days of life was evaluated. Genetic and clinical reference evaluation included SMARCB1 and/or SMARCA4 (fluorescence-in-situ-hybridization, multiplex ligation-dependent probe amplification, and sequencing) mutation analysis and immunohistochemistry...
February 8, 2018: Pediatric Blood & Cancer
J Brett Heimlich, Godwin Chipoka, Laila Elsherif, Emeraghi David, Graham Ellis, Portia Kamthunzi, Robert Krysiak, Pilirani Mafunga, Qingning Zhou, Jianwen Cai, Satish Gopal, Nigel S Key, Kenneth I Ataga
BACKGROUND: Glomerulopathy is an increasingly identified complication in young patients with sickle cell disease (SCD). Hyperfiltration and albuminuria followed by declining glomerular filtration rates and eventual end-stage renal disease (ESRD) is assumed to be the typical progression of glomerular disease. There are only a few reported biomarkers to identify early-stage renal disease in SCD. PROCEDURES: We detail the renal profile of 101 children with SCD in Malawi and propose a novel urinary biomarker for the identification of early renal disease...
February 7, 2018: Pediatric Blood & Cancer
Rachel Tillery, Sarah J Beal, Aimee N Thompson, Ahna L H Pai
Late physical and emotional effects of cancer treatment pose a burden for adolescent and young adult survivors of childhood cancer, including family milestone achievement. This brief report examined links between ongoing cancer-related post-traumatic stress symptoms (CR-PTSS) and family milestone achievement. Survivors (n = 51; Mage  = 24.73, SD = 8.20) completed CR-PTSS and family formation questionnaires. Descriptive statistics, univariate parameter-constraints, and correlation analyses examined relations among study variables...
February 7, 2018: Pediatric Blood & Cancer
Margaret C Cupit-Link, Mira A Kohorst, Cheryl L Tran, Jack J Bleesing, Paul J Galardy, Thomas G Boyce
No abstract text is available yet for this article.
February 7, 2018: Pediatric Blood & Cancer
Gengwen Tian, Van Henry Savell, Jose M Esquilin
No abstract text is available yet for this article.
February 5, 2018: Pediatric Blood & Cancer
Laura Agresta, Hee Kim, Brian K Turpin, Rajaram Nagarajan, Alexandra Plemmons, Sara Szabo, Roshni Dasgupta, Joel I Sorger, Joseph G Pressey
BACKGROUND: Desmoid tumors/aggressive fibromatosis (DT/AF) lack a reliably effective medical therapy. Surgical resection may be morbid and does not preclude recurrence. Radiation may carry severe late effects, particularly detrimental in young patients. At our institution, we recently observed promising results with pazopanib therapy for DT/AF in adolescent and young adult (AYA) patients. PROCEDURE: Retrospective single-institution chart review. RESULTS: Six DT/AF patients of 3-21 years with previously treated DT/AF received pazopanib; 31 DT/AF patients received established therapies only...
January 31, 2018: Pediatric Blood & Cancer
Angela M Feraco, Sarah R Brand, Joshua Gagne, Amy Sullivan, Susan D Block, Joanne Wolfe
BACKGROUND: Families' communication needs during the early cancer treatment period (ECTP) may not be optimally met by current practices. We sought to identify potential communication gaps and to ameliorate these by developing a novel in-depth conversation between families and their pediatric oncologists, the "Day 100 Talk" (D100), during the ECTP. PROCEDURE: We conducted semistructured interviews with parents and patients undergoing childhood cancer treatment for < 7 months...
January 31, 2018: Pediatric Blood & Cancer
William L Carroll, Stephen P Hunger
No abstract text is available yet for this article.
January 31, 2018: Pediatric Blood & Cancer
Satoru Hamada, Jiro Miyamoto, Tokiko Oshiro, Takeshi Yagi, Shinobu Kiyuna, Taichi Uehara, Takehiro Matsuda, Takeshi Higa, Nobuyuki Hyakuna, Koichi Nakanishi
PURPOSE: Pericardial effusion (PE) is a potentially life-threatening complication following hematopoietic stem cell transplantation (HCT). A higher incidence of early-onset PE, unrelated to graft-versus-host disease, before day 100 after HCT has been reported in pediatric patients, but the pathogenic mechanism is poorly understood. Aiming to determine the pathogenesis of early-onset PE in pediatric patients, we analyzed the cytokine concentration and cell population in the pericardial fluid of four pediatric patients with PE...
January 31, 2018: Pediatric Blood & Cancer
Rong Liu, Cheng Jin, Baozhen Huang, Jianxin Wu, Xiaodong Shi
No abstract text is available yet for this article.
January 31, 2018: Pediatric Blood & Cancer
Miranda L Camet, Susan S Hayashi, Belinda C Sinks, Jennifer Henry, Katie Gettinger, Ashley Hite, Juliann Kiefer, Caroline Mohrmann, Taryn Sandheinrich, Feng Gao, Robert J Hayashi
BACKGROUND: Sensorineural hearing loss due to ototoxic cancer therapy is well established; effects on the vestibular system are unknown. We examined the feasibility of implementing vestibular screens for pediatric cancer survivors exposed to ototoxic agents. The prevalence of screening failures is reported. METHODS: Cancer survivors who were 6-17 years, at least 1-month posttreatment, and received ototoxic therapy (radiation to the head/neck, cisplatin, carboplatin) were eligible...
January 30, 2018: Pediatric Blood & Cancer
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