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Pediatric Allergy and Immunology

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https://www.readbyqxmd.com/read/28423474/nasal-obstructive-disorders-impair-health-related-quality-of-life-in-adolescents-with-persistent-allergic-rhinitis-a-real-life-study
#1
Meritxell Valls-Mateus, Franklin Marino-Sanchez, Karen Ruiz-Echevarría, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Blasco-Lozano, María Teresa Giner-Muñoz, Oliver Haag, Isam Alobid, Ana María Plaza Martin, Joaquim Mullol
BACKGROUND: We previously reported a higher prevalence of nasal obstructive disorders (NOD) in pediatric patients with persistent allergic rhinitis (PER) not responding to medical treatment. The aim of this study was to determine the impact of NOD on quality of life (QoL) in this population. METHODS: Real-life prospective study including 142 patients (41 children, 6-11 yo and 101 adolescents, 12-17 yo) with moderate and severe PER. After two months of medical treatment (intranasal steroids and antihistamines) patients were asked if their symptoms had improved (yes/no) and classified accordingly in R, responders and NR, non-responders...
April 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28423473/prediction-of-cashew-nut-allergy-in-sensitised-children
#2
LETTER
Johanna P M van der Valk, Yvonne Vergouwe, Roy Gerth van Wijk, Ewout W Steyerberg, Marit Reitsma, Harry J Wichers, Huub F J Savelkoul, Berber Vlieg-Boerstra, Hans de Groot, Anthony E J Dubois, Nicolette W de Jong
As an alternative to the costly, time-consuming and possibly stressful double-blind, placebo-controlled challenge (DBPCFC) test, a model to predict the risk of cashew nut allergy was studied incorporating patient characteristics, standard diagnostic parameters (specific IgE (sIgE) and Skin Prick Test (SPT)) as well as component resolved diagnosis (CRD This article is protected by copyright. All rights reserved.
April 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28423467/early-life-antibiotic-use-and-the-risk-of-asthma-and-asthma-exacerbations-in-children
#3
Fariba Ahmadizar, Susanne J H Vijverberg, Hubertus G M Arets, Anthonius de Boer, Steve Turner, Graham Devereux, Ali Arabkhazaeli, Patricia Soares, Somnath Mukhopadhyay, Johan Garssen, Colin N A Palmer, Johan C de Jongste, Vincent Wv Jaddoe, Liesbeth Duijts, Evelien R van Meel, Aletta D Kraneveld, Anke H Maitland-van der Zee
BACKGROUND: The use of antibiotic therapy early in life might influence the risk of developing asthma. Studies assessing the influence of early life antibiotic use on the risk of asthma exacerbations are limited, and the results are inconsistent. Therefore, the aim of this study was to assess the association between use of antibiotic during the first three years of life and the risk of developing childhood asthma and the occurrence of asthma exacerbations. METHODS: Data from four large childhood cohorts were used; two population-based cohorts to study the risk of developing asthma: Generation R (n=7,393, the Netherlands) and SEATON (n=891, Scotland, UK), and two asthma cohorts to assess the risk of asthma exacerbations: PACMAN (n=668, the Netherlands) and BREATHE (n=806, Scotland, UK)...
April 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28378348/serum-eicosanoid-analysis-in-chinese-pediatric-patients-with-asthma
#4
LETTER
Zhi-Gang Gong, Jin Liu, Guo-Chang Yin, Yong-Jiang Xu
Asthma is a reversible obstructive lung disease, caused by increased reaction of the airways as various stimuli, and is diagnosed by the medical measurement of the airflow in and out of the lungs. However, children who are pre-school age or younger may be unable to complete the airflow test which requires blowing very hard into a tube (1). Therefore, it is vital to develop a simple and fast method for the determination of pediatric asthma (2). This article is protected by copyright. All rights reserved.
April 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28375580/inflammatory-events-during-food-protein-induced-enterocolitis-syndrome-reactions
#5
Valentina Pecora, Giusi Prencipe, Rocco Valluzzi, Lamia Dahdah, Antonella Insalaco, Antonella Cianferoni, Fabrizio De Benedetti, Alessandro Fiocchi
BACKGROUND: An increasing number of infants are diagnosed with food protein induced enterocolitis syndrome (FPIES), a non-IgE-mediated food allergy. Until now, T-cell, food-specific mechanisms have been hypothesized. METHODS: 16 children (11M, 5F), affected by FPIES from cow's milk, wheat, fruit, rice and others, experienced 25 acute episodes managed at our Emergency Department (ED) and eight FPIES reactions during oral food challenges (OFC). We compared the laboratory data in resting conditions, in absence of infectious diseases, with data collected during the 25 acute ED episodes (blood samples drawn at 2 to 12 hours) and the eight positive OFCs (three samples at 2, 6 and 12 hours)...
April 4, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339145/respiratory-syncytial-virus-host-interaction-in-the-pathogenesis-of-bronchiolitis-and-its-impact-on-respiratory-morbidity-in-later-life
#6
REVIEW
Giovanni A Rossi, Andrew A Colin
Rossi GA, Colin AA(.) Respiratory syncytial virus - host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life. Pediatr Allergy Immunol. Respiratory syncytial virus (RSV) is the most common agent of severe airway disease in infants and young children. Large epidemiologic studies have demonstrated a clear relationship between RSV infection and subsequent recurrent wheezing and asthma into childhood, thought to be predominantly related to long-term changes in neuroimmune control of airway tone rather than to allergic sensitization...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339137/perioperative-midazolam-hypersensitivity-in-a-seven-year-old-boy
#7
LETTER
Roberto Bernardini, Patrizia Bonadonna, Piera Catania, Giovanni Passalacqua
Midazolam is a short-acting benzodiazepine with a central nervous system depressing action. The pharmacologic properties of midazolam and its metabolites (similar to those of other benzodiazepines), include sedative, anxiolytic, amnesic and hypnotic activities. The favorable clinical aspects of the use of benzodiazepines are the result of a reversible allosteric interaction with the (gamma)-amino butyric acid (GABA) receptor A, that accounts for the major inhibitory neurotransmitter pathway within the central nervous system (1)...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339136/eosinophilic-oesophagitis-phenotypes-ready-for-primetime
#8
REVIEW
Dan Atkins, Glenn T Furuta, Chris A Liacouras, Jonathan M Spergel
Eosinophilic Oesophagitis (EoE) is one of the most common causes of reflux like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids or dilation. In the last several years, recent clinical and translational research have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggests that various phenotypes may also exist in patients with EoE...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339130/partially-hydrolyzed-whey-formula-intolerance-in-cow-s-milk-allergic-patients
#9
LETTER
Maureen Egan, Tricia Lee, Jade Andrade, Galina Grishina, Michelle Mishoe, Gustavo Gimenez, Hugh A Sampson, Supinda Bunyavanich
Cow's milk allergy (CMA) is one of the most common food allergies in young children, affecting 2-3% of the pediatric population (1). Hypoallergenic formula is recommended for infants with CMA who are not breastfeeding (2). Extensively hydrolyzed or amino acid-based formulas are tolerated in over 90% of infants with CMA(2). This article is protected by copyright. All rights reserved.
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339128/life-course-of-atopy-and-allergy-related-disease-events-in-tropical-sub-saharan-africa-a-birth-cohort-study
#10
Swaib A Lule, Harriet Mpairwe, Margaret Nampijja, Florence Akello, Joyce Kabagenyi, Benigna Namara, Gyaviira Nkurunungi, Dennison Kizito, Joseph Kahwa, Lawrence Muhangi, Stephen Nash, Moses Muwanga, Emily L Webb, Alison M Elliott
BACKGROUND: In high-income countries, allergy related-diseases (ARDs) follow a typical sequence, the "Atopic March". Little is known about the life-course of ARDs in the markedly different, low-income, tropical environment. We describe ARDs in a tropical, African birth cohort. METHODS: Ugandan children were followed from birth to nine years. ISAAC questionnaires were completed at intervals; doctor-diagnosed ARDs were recorded throughout follow-up. Skin prick tests (SPTs) were done at three and nine years...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339124/gliadin-reactive-t-cells-in-italian-children-from-preventcd-cohort-at-high-risk-for-celiac-disease
#11
Alessandra Camarca, Renata Auricchio, Stefania Picascia, Olga Fierro, Mariantonia Maglio, Erasmo Miele, Basilio Malamisura, Luigi Greco, Riccardo Troncone, Carmen Gianfrani
BACKGROUND: Newborns at high risk for celiac disease (CD) were recruited in Italy in the context of the PreventCD Study and closely monitored for CD, from 4 months up to a mean age of 8 years at follow-up. The aim of our study was to investigate intestinal T cell reactivity to gliadin at the first clinical and/or serological signs of CD. METHODS: Gliadin-reactive T cell lines were generated from intestinal biopsies of 19 HLA-DQ2 or HLA-DQ8 positive children. At biopsy, 11 children had a diagnosis of acute CD, two of potential CD, and six were non-celiac controls...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28301056/age-at-onset-and-persistence-of-eczema-are-related-to-subsequent-risk-of-asthma-and-hay-fever-from-birth-to-18-years-of-age
#12
Adrian J Lowe, Bianca Angelica, John Su, Caroline J Lodge, David J Hill, Bircan Erbas, Catherine M Bennett, Lyle C Gurrin, Christine Axelrad, Michael J Abramson, Katrina J Allen, Shyamali Dharmage
BACKGROUND: Few studies have simultaneously addressed the importance of age of onset and persistence of eczema for the subsequent development of asthma and hay fever, particularly into early adulthood. METHODS: A high risk birth cohort was recruited comprising 620 infants, who were then followed up frequently until two years of age, annually from age 3 to 7, then at 12 and 18 years, to document any episodes of eczema, current asthma and hay fever. The generalised estimation equation technique was used to examine asthma and hay fever outcomes at 6 (n=325), 12 (n=248) and 18 (n=240) years, when there was consistency of associations across the follow-ups...
March 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28258590/health-related-quality-of-life-among-children-with-hereditary-angioedema
#13
Batya Engel-Yeger, Henriette Farkas, Shmuel Kivity, Nóra Veszeli, Kinga Viktória Kőhalmi, Aharon Kesssel
BACKGROUND: The clinical expressions of hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) and its related burden may negatively affect patient quality of life. This study aims to assess health-related quality of life (HRQoL) in children with C1-INH-HAE. METHODS: Children (N=98: 34 C1-INH-HAE patients, 64 healthy controls) aged 3-18 years were recruited in Israel and Hungary. All individuals completed a demographic questionnaire, a disease activity and site questionnaire, and the Pediatric Quality of Life Inventory (PedsQL(™) ) 4...
March 4, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28235144/allergen-sensitization-affected-the-change-trend-of-prevalence-of-symptoms-of-rhinitis-co-existing-with-wheeze-among-adolescents-in-guangzhou-city-from-1994-to-2009
#14
Yan Chen, Hongyu Wang, Gary Wk Wong, Nanshan Zhong, Jing Li
BACKGROUND: Few studies have assessed the time trends of prevalence of symptoms of rhinitis (SR) with wheezing and their associations in Chinese adolescents. OBJECTIVE: To explore the trend of prevalence of SR with wheezing and allergen sensitization in adolescents during the past 15 years. METHODS: A total of 7165 adolescents aged 13-14 years in 2009 were recruited for the study using the Phase III Protocol of the International Study of Asthma and Allergic disease in Childhood (ISAAC) and allergic sensitization to seven inhalant allergens in 2531 was assessed by skin prick test in 2010...
February 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28235137/wheezing-and-the-first-thousand-days-of-life
#15
LETTER
Carolina Sanchez Aranda, Gustavo Falbo Wandalsen, Ana Caroline Dela Bianca, Lilian Moraes, Mercia Lamenha, Javier Mallol, Dirceu Solé
There is a recent discussion on the importance of the first thousand days of a child's life. This period covers from conception to the end of the second year of life (1). Recent studies suggest that this period is an open window for interventions and that such interventions may spread to the rest of life (2,3). This article is protected by copyright. All rights reserved.
February 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28218956/nasal-budesonide-efficacy-for-nasal-nitric-oxide-and-nasal-obstruction-in-rhinitis
#16
LETTER
Giuliana Ferrante, Salvatore Fasola, Giovanna Cilluffo, Velia Malizia, Laura Montalbano, Massimo Landi, Giovanni Passalacqua, Stefania La Grutta
Nasal nitric oxide (nNO) is a noninvasive tool that may be helpful in evaluating the inflammatory status in the upper airways [1]. Previous studies report that nNO is elevated in children with Allergic Rhinitis (AR) [2], especially in perennial sensitized subjects [3], and that it may be affected by topical administration of intranasal steroids (INSs) [4]. This article is protected by copyright. All rights reserved.
February 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28211100/safety-and-feasibility-of-heated-egg-yolk-challenge-for-children-with-egg-allergies
#17
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28211092/ultraviolet-index-is-associated-with-childhood-eczema-prevalence-sex-and-age-differences
#18
LETTER
Koichi Yoshida, Yuichi Adachi, Mari Sasaki, Masayuki Akashi, Toshiko Itazawa, Yukihiro Ohya, Hiroshi Odajima, Akira Akasawa
Eczema is a chronic inflammatory skin condition whose development is related to environmental and genetic factors. The report of a positive association of latitude with the prevalence of childhood eczema suggests an important role for climate in the pathogenesis of eczema (1). The effect of ultraviolet (UV) radiation exposure is one of the candidate explanations for this observation, and is corroborated by a study in the United States reporting an inverse relationship between UV index and the prevalence of childhood eczema (2)...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28208225/indoor-fungal-diversity-in-primary-schools-may-differently-influence-allergic-sensitization-and-asthma-in-children
#19
João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, Cristiana Pereira, Diana Silva, Patrícia Padrão, Pedro Moreira, Luís Delgado, Isabella Annesi-Maesano, Eduardo Oliveira Fernandes, João Paulo Teixeira, André Moreira
BACKGROUND: Childhood exposure to microbiologic agents may influence the development of allergic and respiratory diseases. Apart from home, children spend most of their time at school, which represents an environment of significant exposure to indoor air microbes. Therefore, we aimed to assess how the prevalence of allergic sensitization and asthma in schoolchildren is affected by microbiologic exposure within classrooms. METHODS: Spirometry with bronchodilation, exhaled nitric oxide measurements and skin-prick tests data were retrieved from 858 children aged 8-10 years attending 71 classrooms in 20 primary schools...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28140473/detection-of-ovomucoid-specific-low-affinity-ige-in-infants-and-its-relationship-to-eczema
#20
Norio Kawamoto, Norio Kamemura, Kido Hiroshi, Toshiyuki Fukao
BACKGROUND: Allergen-specific low-affinity IgE was previously detected in cord blood by a highly sensitive densely carboxylated protein (DCP) chip, but not by ImmunoCAP. Here, we investigated the presence of low-affinity IgE during the early life of infants and observed its relationship with eczema. METHODS: We conducted a birth cohort study, collecting sera at birth and 6 (6M) and 14 months (14M) of age (n=110). We monitored the ovomucoid (OM)- and egg white (EW)-specific-IgE (sIgE) by ImmunoCAP or DCP-chip and analyzed the antigen-affinity of sIgE by binding inhibition assays in the presence or absence of a mild chaotropic agent, diethyl amine (DEA)...
January 31, 2017: Pediatric Allergy and Immunology
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