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Pediatric Allergy and Immunology

Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
Koichi Yoshida, Yuichi Adachi, Mari Sasaki, Masayuki Akashi, Toshiko Itazawa, Yukihiro Ohya, Hiroshi Odajima, Akira Akasawa
Eczema is a chronic inflammatory skin condition whose development is related to environmental and genetic factors. The report of a positive association of latitude with the prevalence of childhood eczema suggests an important role for climate in the pathogenesis of eczema (1). The effect of ultraviolet (UV) radiation exposure is one of the candidate explanations for this observation, and is corroborated by a study in the United States reporting an inverse relationship between UV index and the prevalence of childhood eczema (2)...
February 16, 2017: Pediatric Allergy and Immunology
João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, Cristiana Pereira, Diana Silva, Patrícia Padrão, Pedro Moreira, Luís Delgado, Isabella Annesi-Maesano, Eduardo Oliveira Fernandes, João Paulo Teixeira, André Moreira
BACKGROUND: Childhood exposure to microbiological agents may influence the development of allergic and respiratory diseases. Apart from home, children spend most of their time at school, which represents an environment of significant exposure to indoor air microbes. Therefore, we aimed to assess how the prevalence of allergic sensitization and asthma in schoolchildren is affected by microbiological exposure within classrooms. METHODS: Spirometry with bronchodilation, exhaled nitric oxide measurements and skin-prick tests data were retrieved from 858 children aged 8 to 10 years old attending 71 classrooms in 20 primary schools...
February 16, 2017: Pediatric Allergy and Immunology
G Pouessel, J Galand, E Beaudouin, J M Renaudin, J Labreuche, D A Moneret-Vautrin, A Deschildre
Several studies have assessed the knowledge of health professionals in recognition and treatment of anaphylaxis using case-based surveys with conflicting results [1-3]. The proportion of responders able to recognize anaphylaxis and treat with appropriate adrenaline ranged from 56% to 95% [1, 3]. The causes for this under optimal management are not clearly understood. In this context, EAACI anaphylaxis guidelines were recently updated. This article is protected by copyright. All rights reserved.
February 8, 2017: Pediatric Allergy and Immunology
Mathias Cousin, Stéphane Verdun, Maxime Seynave, Anne-Christine Vilain, Amélie Lansiaux, Anne Decoster, Christine Sauvage
BACKGROUND: Peanut allergy in children is often associated with allergies to tree nuts and/or legumes. The aim of the present study was to analyze in cluster a cohort of children allergic to peanuts and assessed for cross-reactivity to nuts and legumes and to identify different phenotypes. METHODS: We included retrospectively 317 children with peanut allergy evaluated at the Allergy Unit of the Saint Vincent Hospital of Lille in the last 12 years. A complete work-up for peanut allergy and nuts and legumes was carried out for each patient...
January 31, 2017: Pediatric Allergy and Immunology
Julie Chastang, Nour Baiz, Laure Parnet, Jean Sébastien Cadwallader, Frédéric De Blay, Denis Caillaud, Denis André Charpin, John Dwyer, François Lavaud, Chantal Raherison, Gladys Ibanez, Isabella Annesi-Maesano
BACKGROUND: It is known that asthma is related to obesity but also to small birth weight. The objective of the present study was to clarify this issue by assessing the putative relationship between the change between birth and childhood in child's corpulence as assessed by body mass index (BMI) and asthma phenotypes. METHODS: The following status in corpulence were assessed in 7781 schoolchildren using quartile of BMI at birth and at around 10 (9-11years): underweight at birth and at around 10, underweight at birth and overweight at around 10, overweight at birth and underweight at around 10, overweight at birth and at around 10 and the reference group constituted by all the other children in whom corpulence changes were not extreme...
January 31, 2017: Pediatric Allergy and Immunology
Norio Kawamoto, Norio Kamemura, Kido Hiroshi, Toshiyuki Fukao
BACKGROUND: Allergen-specific low-affinity IgE was previously detected in cord blood by a highly sensitive densely carboxylated protein (DCP) chip, but not by ImmunoCAP. Here, we investigated the presence of low-affinity IgE during the early life of infants and observed its relationship with eczema. METHODS: We conducted a birth cohort study, collecting sera at birth and 6 (6M) and 14 months (14M) of age (n=110). We monitored the ovomucoid (OM)- and egg white (EW)-specific-IgE (sIgE) by ImmunoCAP or DCP-chip and analyzed the antigen-affinity of sIgE by binding inhibition assays in the presence or absence of a mild chaotropic agent, diethyl amine (DEA)...
January 31, 2017: Pediatric Allergy and Immunology
Carmen García-Ara, María Pedrosa, Santiago Quirce, Teresa Caballero, Teresa Boyano-Martínez
Microarrayed allergen immunoassays are increasingly being used to determine sensitization to multiple allergenic components(1) . However, there is scarce data on the development and progression of sensitization to vegetal allergens in early life. This study aimed to detect the profile of sensitization to allergenic components from vegetal foods and pollens using ISAC-IgE microarray (ISAC-IgE) (Thermo Fisher Scientific, Uppsala, Sweden) over 4 years in children diagnosed with allergy to cow's milk proteins (CMPA)...
January 31, 2017: Pediatric Allergy and Immunology
Tomoyuki Asaumi, Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Motohiro Ebisawa
Kiwifruit allergy appears to be increasing (1). Symptoms of kiwifruit allergy vary from localized oral symptoms to life-threatening anaphylaxis (2, 3). Kiwifruit allergy is generally diagnosed based on medical history, positive specific immunoglobulin E (IgE) to kiwifruit, and oral food challenge (OFC). It is important to identify biomarkers to differentiate severe symptoms from localized oral symptoms. However, commercially available in vitro tests for specific IgE antibodies to crude kiwifruit extracts cannot predict severe kiwifruit allergy (4, 5)...
January 31, 2017: Pediatric Allergy and Immunology
S C Hammer, L J H Sonneveld, K D G van de Kant, H J Hendriks, J W Heynens, R Droog, E Dompeling, Q Jöbsis
BACKGROUND: In 2008, a new national paediatric asthma management guideline based on the international Global Initiative for Asthma (GINA) guideline, was launched in the Netherlands. We studied whether asthma control and treatment regimens improved after introduction of the guideline by comparing survey data before and after the guideline introduction. METHODS: Two comparable groups of children (6-16 years) with asthma were included before (2004) and after (2013) the introduction of the guideline...
January 20, 2017: Pediatric Allergy and Immunology
Hamid Nawaz Tipu
No abstract text is available yet for this article.
January 20, 2017: Pediatric Allergy and Immunology
Rodolphe Dard, Bérénice Herve, Thierry Leblanc, Jean-Pierre De Villartay, Laura Collopy, Tom Vulliami, Severine Drunat, Stephanie Gorde, Abel Babik, Pierre-François Souchon, Aomar Agadr, Rachid Abilkassem, Mustapha Elalloussi, Alain Verloes, Martine Doco-Fenzy
DNA ligase IV (LIG4) deficiency (LIG4 syndrome, LS, OMIM 606593) is a very rare autosomal-recessive DNA-repair disorder first reported in 2001(1). In LS, genome instability results in a broad range of Onco-Hemato-Immunological disturbances, including progressive pancytopenia in childhood, and severe combined immunodeficiency (SCID) B(-) T(-) NK(+) and malignancy; it is also associated with microcephalic developmental delay, short stature, and facial dysmorphism. Clinical presentation ranges in severity from rapidly fatal to mild hemato-immunological forms associated with microcephalic developmental delay...
December 31, 2016: Pediatric Allergy and Immunology
Debra J Palmer, Susan L Prescott
Over the past two decades we have been debating the question of whether the age of commencement of complementary feeding affects the risk of developing food allergy. We ate up the notion that delayed introduction of more allergenic foods in early childhood, would help overcome the increasing rates of food allergy, then we promptly spat it out again despite limited evidence. Recently high-quality randomised controlled trial evidence has given us the confidence to swallow the concept that allergenic foods, like egg and peanut, should be given to infants...
December 31, 2016: Pediatric Allergy and Immunology
Hakan Guvenir, Emine Dibek Misirlioglu, Fatma Aydin, Dilek Ece, Nilgun Cakar, Can Naci Kocabas
No abstract text is available yet for this article.
December 31, 2016: Pediatric Allergy and Immunology
J Saleh-Langenberg, S de Vries, E Bak, B J Kollen, B M J Flokstra-de Blok, A E J Dubois
BACKGROUND: Successful treatment of anaphylaxis in the community relies on early and correct use of epinephrine auto-injectors (EAI). In the Netherlands pharmacists supply EAIs to patients and have a crucial role in instructing patients in how and when to use EAI. However, there are currently no data in Europe on the quality of such instruction provided by pharmacists. Therefore, the aims of this study were to investigate the knowledge, attitudes, and beliefs regarding food allergy among pharmacists in the Netherlands, and to investigate the quality of EAI instructions and demonstrations to patients by pharmacists...
December 19, 2016: Pediatric Allergy and Immunology
Rosita Aitoro, Raffaele Simeoli, Antonio Amoroso, Lorella Paparo, Rita Nocerino, Claudio Pirozzi, Margherita Di Costanzo, Rosaria Meli, Carmen De Caro, Gianluca Picariello, Gianfranco Mamone, Antonio Calignano, Cathryn R Nagler, Roberto Berni Canani
BACKGROUND: Extensively hydrolyzed casein formula (EHCF) has been proposed for the prevention and is commonly used for the treatment of cow's milk allergy (CMA). The addition of the probiotic Lactobacillus rhamnosus GG (LGG) to EHCF may induces faster acquisition of tolerance to cow's milk. The mechanisms underlying this effect are largely unexplored. We investigated the effects of EHCF alone or in combination with LGG on β-lactoglobulin (BLG) sensitization in mice. METHODS: Three-weeks old C3H/HeOuJ mice were sensitized by oral administration of BLG using cholera toxin as adjuvant at weekly intervals for 5 weeks (sensitization period)...
December 19, 2016: Pediatric Allergy and Immunology
R X Foong, R Meyer, H Godwin, R Dziubak, A C Lozinsky, K Reeve, R Knibb, N Shah
BACKGROUND: Food allergy can have a significant impact on health-related quality of life (HRQoL). Parental proxy questionnaires are commonly used when children are too young to complete questionnaires themselves. Little data are available on HRQoL in children with non-IgE-mediated gastrointestinal food allergy (GIFA). The aim of this study was to evaluate HRQoL in these children by parent proxy. METHODS: A cross-sectional questionnaire study was conducted with children aged 2-16 years with confirmed GIFA...
December 19, 2016: Pediatric Allergy and Immunology
David Drummond, Delphine Monnier, Antoine Tesnière, Alice Hadchouel
BACKGROUND: Serious games may be useful tools for asthma education. The objectives of this systematic review were to identify the available articles on serious games designed to educate patients and the general public about asthma and to assess their impact on patient's knowledge, behavior, and clinical outcomes related to asthma. METHODS: PubMed, EMBASE, Cochrane Library, PsychInfo, and Web of Science were systematically searched from January 1980 to December 2015 for studies investigating serious games in asthma education...
December 19, 2016: Pediatric Allergy and Immunology
Hasti Hadizadeh, M Masoud Salehi, Shabnam Khoramnejad, Kia Vosoughi, Nima Rezaei
BACKGROUND: We aimed to establish the prevalence of parental consanguinity among patients with primary immunodeficiency diseases (PID), and compare the prevalence with the general population. METHOD: We searched PubMed, EMBASE, and Scopus for studies mentioning parental consanguinity prevalence in PID patients and calculated the prevalence odds ratio (POR) of parental consanguinity in each study, compared to a matched healthy population. RESULTS: We identified 21 eligible studies with a total population of 18091 accounting for sample overlap...
November 28, 2016: Pediatric Allergy and Immunology
Cristina Cifaldi, Giulia Angelino, Maria Chiriaco, Silvia Di Cesare, Alessia Claps, Jessica Serafinelli, Paolo Rossi, Antonio Antoccia, Gigliola Di Matteo, Caterina Cancrini, Jean Pierre De Villartay, Andrea Finocchi
The non-homologous end joining (NHEJ) pathway is involved in the repair of the DNA double-strand breaks. Defects in NHEJ factors result in IR sensitivity, and in defects in V(D)J recombination leading to immunodeficiency. DNA Ligase IV is an essential component that performs the final 'end processing' step of NHEJ. This article is protected by copyright. All rights reserved.
November 28, 2016: Pediatric Allergy and Immunology
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