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Pediatric Allergy and Immunology

Sailesh Kotecha, Hege Clemm, Thomas Halvorsen, Sarah J Kotecha
BACKGROUND: Preterm-born survivors have increased respiratory symptoms and decreased lung function, but the nature of bronchial hyper-responsiveness (BHR) is unclear. We conducted a systematic review and meta-analysis for BHR in preterm-born survivors including those with and without chronic lung disease in infancy (CLD) comparing results to term-born subjects. METHODS: We searched eight databases up to December 2016. Included articles compared BHR in preterm-born and term-born subjects...
July 17, 2018: Pediatric Allergy and Immunology
Elise M A Slob, Susanne J H Vijverberg, Colin N A Palmer, Zulfan Zazuli, Niloufar Farzan, Nadia M B Oliveri, Mariëlle W Pijnenburg, Gerard H Koppelman, Anke H Maitland van der Zee
BACKGROUND: Long-acting beta2-agonists (LABA) are recommended in asthma therapy, however, not all asthma patients respond well to LABA. We performed a systematic review on genetic variants associated with LABA response in patients with asthma. METHODS: Articles published until April 2017 were searched by two authors using PubMed and EMBASE. Pharmacogenetic studies in patients with asthma and LABA response as an outcome were included. RESULTS: In total, thirty-three studies were included in this systematic review, eight focused on children (n=6,051)...
July 10, 2018: Pediatric Allergy and Immunology
Frans De Baets, Linde De Keyzer, Sabine Van Daele, Petra Schelstraete, Stephanie Van Biervliet, Eva Van Braeckel, Muriel Thomas, Simeon S Wanyama
BACKGROUND: Allergic Bronchopulmonary aspergillosis (ABPA) is a major complication in CF patients. Risk factors for ABPA and clinical deterioration in CF patients, negative for Pseudomonas aeruginosa (Pa), were explored. METHODS: We performed a retrospective case-control study in 73 Pa-negative patients. Each patient was matched with 2 controls for age, gender, pancreas sufficiency, CFTR mutation (homozygous or heterozygous deltaF508) and Pa colonization. RESULTS: Median FEV1 at the year of diagnosis (index year) was significantly lower in ABPA patients...
July 7, 2018: Pediatric Allergy and Immunology
Luis Felipe Ensina, Patricia Guerzet Ayres Bastos, Alex Eustaquio de Lacerda, Chayanne Andrade de Araujo, Inês Camelo-Nunes, Dirceu Solé
Few data are comparing chronic spontaneous urticaria (CSU) in children and adults. Balp et al conducted an important online survey in five different European countries, with physicians that had seen at least one pediatric patient with CSU in the last 12 months (1). Their results suggest that the prevalence of chronic urticaria and CSU in children is similar to that observed in adults. This article is protected by copyright. All rights reserved.
July 5, 2018: Pediatric Allergy and Immunology
Andrew Timothy Fong, Constance Helen Katelaris, Brynn Kevin Wainstein
BACKGROUND: Food allergy is an increasing concern worldwide. The significant impact of food allergies on quality-of-life and bullying has been well described in international studies. No studies have yet investigated the occurrence of bullying in children and adolescents with food allergies in the Australian population. This study aimed to characterise and examine the frequency of bullying; describe those most responsible and the effects of the bullying on the victims. METHODS: Questionnaires were developed based on those used in previous studies and were distributed throughout paediatric allergy clinics...
July 5, 2018: Pediatric Allergy and Immunology
Ashish Sharma, René Aalbers, Eckard Hamelmann, Stanley Goldstein, Michael Engel, Petra Moroni-Zentgraf, Christian Vogelberg
The efficacy and safety of tiotropium Respimat® , a long-acting muscarinic antagonist (LAMA), as add-on to maintenance inhaled corticosteroids (ICS), with or without additional controllers, has been demonstrated in children aged 6-11 and 12-17 years with symptomatic moderate and severe asthma (1-4). The pharmacokinetic (PK) properties of tiotropium have been reported in adult patients with chronic obstructive pulmonary disease (COPD) (5) and cystic fibrosis (6), and in adults and adolescents with asthma (7), but not in children...
July 4, 2018: Pediatric Allergy and Immunology
Kati Palosuo, Anna Kaarina Kukkonen, Anna Susanna Pelkonen, Mika Juhani Mäkelä
BACKGROUND: Allergen-specific IgE levels can be useful in predicting outcomes of oral food challenges, but optimal cutoff levels vary in different populations. The aim was to determine cutoff values for egg white and Gal d 1,2,3, and 4 -specific IgE (sIgE) predicting positive oral heated egg challenges in 185 Finnish children and adolescents. METHODS: 185 egg-sensitized patients (age 1-19 years, median 6.3, mean 7.0 years) with suspected egg allergy underwent double-blind, placebo-controlled (n=78) or open (n=107) oral food challenges with heated egg white...
July 3, 2018: Pediatric Allergy and Immunology
Anne-Charlotte Jonckheere, Sven F Seys, Ellen Dilissen, Gudrun Marijsse, An-Sofie Schelpe, Sarah Van der Eycken, Tulasi Verhalle, Vincent Vanbelle, Sven Aertgeerts, Thierry Troosters, Koen Peers, Lieven J Dupont, Dominique M A Bullens
Several studies have already identified atopy as a risk factor for the development of exercise-induced bronchoconstriction (EIB) in adult elite athletes (1-3). Skin prick test or serum specific IgE to common aero-allergens is used to determine the patient's atopy status (4). In 2009, Bonini M et al. introduced a screening tool to predict atopy in elite adult athletes, namely the Allergy Questionnaire for Athletes or short the AQUA© questionnaire (5). This article is protected by copyright. All rights reserved...
June 16, 2018: Pediatric Allergy and Immunology
Dong Keon Yon, Young Sun Cho, Eun Kyo Ha, Hye Mi Jee, Joo Young Song, Young-Ho Jung, Kyung Suk Lee, Youn Ho Sheen, Man Yong Han
No abstract text is available yet for this article.
June 8, 2018: Pediatric Allergy and Immunology
Sara S Shagiwal, Herman T den Dekker, Johan C de Jongste, Guy G Brusselle, Vincent W V Jaddoe, Janine F Felix, Liesbeth Duijts
Genetic variants associated with adult lung function could already exert the effects on childhood lung function. We aimed to examine the associations of adult lung function-related genetic variants with childhood lung function and asthma, and whether these associations were modified by atopic predisposition, tobacco smoke exposure, or early growth characteristics. In a population-based prospective cohort study among 3347 children, we selected 7 and 20 single nucleotide polymorphisms (SNPs) associated with adult forced expiratory volume in 1 second (FEV1 ) and FEV1 /forced vital capacity (FEV1 /FVC), respectively...
June 7, 2018: Pediatric Allergy and Immunology
Pauline Chan Ng, Chiung-Hui Huang, Mohana Rajakulendran, Michelle Meiling Tan, Ping Ping Wang, Lei Qiu Tay, Siok Ying Goh, Lynette Pei-Chi Shek, Elizabeth Huiwen Tham
No abstract text is available yet for this article.
May 29, 2018: Pediatric Allergy and Immunology
Styliana Vasileiadou, Göran Wennergren, Frida Strömberg Celind, Nils Åberg, Rolf Pettersson, Bernt Alm, Emma Goksör
No abstract text is available yet for this article.
May 29, 2018: Pediatric Allergy and Immunology
Henry Y Lu, Mehul Sharma, Catherine M Biggs, Yu-Hsuan Huang, Kevin E Shopsowitz, Patrick Frosk, John J Priatel, Tamar S Rubin, Stuart E Turvey
No abstract text is available yet for this article.
May 29, 2018: Pediatric Allergy and Immunology
Janusz Ciółkowski, Henryk Mazurek, Paweł Hydzik, Barbara Stasiowska, Elżbieta Mazurek
Remission of asthma may occur at any age, but most commonly presents during adolescence and young adulthood. Eosinophilic inflammation is the predominant type of inflammation in asthmatic children and adolescents - also present during the remission of asthma [1,2]. The persistence of eosinophilic inflammation is a risk factor for recurrence of asthma in adulthood and the reduction of lung function [1]. This article is protected by copyright. All rights reserved.
May 28, 2018: Pediatric Allergy and Immunology
Wenlong Liu, Qingxiang Zeng, Lifeng Zhou, Yan Li, Yanqiu Chen, RenZhong Luo
BACKGROUND: Recent studies suggest that T helper 17 (Th17) cell subset, a distinct pro-inflammatory CD4 +  T cell lineage, may play an important role in the pathophysiology of allergic rhinitis (AR). However, the regulation of Th17 response in allergic disease is not well characterized. METHODS: Thirty AR and 30 healthy children were enrolled. Serum leptin and OPN levels were measured, and their correlation with IL-17 expression was analyzed using enzyme-linked immunosorbent assay (ELISA)...
May 28, 2018: Pediatric Allergy and Immunology
Carina Venter, Kate Maslin, Hongmei Zhang, Akhilesh Kaushal, William Terry, Veeresh K Patil, Tara Dean, Syed Hasan Arshad
Multiple tests are available to determine food and aero-allergen sensitization (1,2), but it is unclear if distinct sensitization patterns can be determined by using a combination of three testing modalities; skin prick test (SPT), specific IgE test and component resolved diagnostic tests to characterize or identify certain clinical phenotypes. This is a novel paper utilizing sensitization clusters (SPT, specific IgE tests and component resolved diagnostics) in an unselected cohort of 10/11 year-old children and its association with asthma, eczema, rhinitis and IgE-mediated food allergy...
May 26, 2018: Pediatric Allergy and Immunology
Mariam Zaidi, Sara Zaidi
It was a pleasure reading the recently published article in your journal: "Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies" by Morales et al [1] Prenatal factors influencing foetal outcomes and early childhood illness represents an important aspect of Paediatric research and one that has a high propensity for applicability to clinical medicine. Whilst reading the article, I had a number of viewpoints to share which I feel the authors may not have accounted for and are relevant to this topic...
May 24, 2018: Pediatric Allergy and Immunology
Niraj C Patel
Primary immunodeficiency diseases (PIDD) are a group of genetic conditions that are generally considered to be under-diagnosed, and gaps may exist in the knowledge of treatment options. This review focuses on the diagnosis of pediatric patients with primary antibody deficiency and considerations for treatment with immunoglobulin (IgG) to optimize multiple dosing variables and minimize adverse events. The possibility of individualizing IgG therapy in clinical practice represents, in this field, the next pivotal step with the goal of improving the quality of life of pediatric patients with PIDD...
May 9, 2018: Pediatric Allergy and Immunology
Arthur H Owora, Allan B Becker, Moira Chan-Yeung, Edmond S Chan, Rishma Chooniedass, Clare Ramsey, Wade T A Watson, Meghan B Azad
BACKGROUND: The objectives of this study were to identify developmental trajectories of wheezing using data-driven methodology, and to examine whether trajectory membership differentially impacts the effectiveness of primary preventive efforts that target modifiable asthma risk factors. METHODS: Secondary analysis of the Canadian Asthma Primary Prevention Study (CAPPS), a multifaceted prenatal intervention among children at high risk of asthma, followed from birth to 15 years...
May 5, 2018: Pediatric Allergy and Immunology
Giorgio Fedele, Ilaria Schiavoni, Raffaella Nenna, Alessandra Pierangeli, Antonella Frassanito, Pasqualina Leone, Laura Petrarca, Carolina Scagnolari, Fabio Midulla
No abstract text is available yet for this article.
April 30, 2018: Pediatric Allergy and Immunology
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