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Pediatric Allergy and Immunology

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https://www.readbyqxmd.com/read/28107572/introduction-of-a-new-paediatric-asthma-guideline-effects-on-asthma-control-levels
#1
S C Hammer, L J H Sonneveld, K D G van de Kant, H J Hendriks, J W Heynens, R Droog, E Dompeling, Q Jöbsis
BACKGROUND: In 2008, a new national paediatric asthma management guideline based on the international Global Initiative for Asthma (GINA) guideline, was launched in the Netherlands. We studied whether asthma control and treatment regimens improved after introduction of the guideline by comparing survey data before and after the guideline introduction. METHODS: Two comparable groups of children (6-16 years) with asthma were included before (2004) and after (2013) the introduction of the guideline...
January 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28107557/leukocyte-adhesion-deficiency-type-i-a-rare-primary-immunodeficiency-disorder
#2
LETTER
Hamid Nawaz Tipu
Leukocyte adhesion deficiency type I (LAD-I) is a rare autosomal recessive primary immunodeficiency disorder that is caused by mutations in ITGB2 gene encoding β2 subunit (CD18) of integrins(1) . Integrins are required for neutrophils adhesion to endothelium during their emigration to inflammatory site. Hence, integrin deficiency leads to poor neutrophils extravasation, neutrophilia, lack of pus formation and recurrent bacterial infections(2) . Clinical suspicion is confirmed with integrins detection on neutrophils surface by flow cytometry...
January 20, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28039949/dna-ligase-iv-deficiency-immunoglobulin-class-deficiency-depends-on-the-genotype
#3
LETTER
Rodolphe Dard, Bérénice Herve, Thierry Leblanc, Jean-Pierre De Villartay, Laura Collopy, Tom Vulliami, Severine Drunat, Stephanie Gorde, Abel Babik, Pierre-François Souchon, Aomar Agadr, Rachid Abilkassem, Mustapha Elalloussi, Alain Verloes, Martine Doco-Fenzy
DNA ligase IV (LIG4) deficiency (LIG4 syndrome, LS, OMIM 606593) is a very rare autosomal-recessive DNA-repair disorder first reported in 2001(1). In LS, genome instability results in a broad range of Onco-Hemato-Immunological disturbances, including progressive pancytopenia in childhood, and severe combined immunodeficiency (SCID) B(-) T(-) NK(+) and malignancy; it is also associated with microcephalic developmental delay, short stature, and facial dysmorphism. Clinical presentation ranges in severity from rapidly fatal to mild hemato-immunological forms associated with microcephalic developmental delay...
December 31, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28039897/early-introduction-of-food-reduces-food-allergy-pro
#4
Debra J Palmer, Susan L Prescott
Over the past two decades we have been debating the question of whether the age of commencement of complementary feeding affects the risk of developing food allergy. We ate up the notion that delayed introduction of more allergenic foods in early childhood, would help overcome the increasing rates of food allergy, then we promptly spat it out again despite limited evidence. Recently high-quality randomised controlled trial evidence has given us the confidence to swallow the concept that allergenic foods, like egg and peanut, should be given to infants...
December 31, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28039896/successful-methyl-prednisolone-desensitization-in-a-pediatric-patient
#5
LETTER
Hakan Guvenir, Emine Dibek Misirlioglu, Fatma Aydın, Dilek Ece, Nilgün Çakar, Can Naci Kocabas
Corticosteroids (CS) have anti-inflammatory and immuno-suppressive effects and which they are widely used for allergic diseases, autoimmune and immune-related diseases. CS cause rarely immediate type hypersensitivity reactions after administration of oral and parenteral. Incidence of reaction has been reported 0.3-0.5% (1, 2). Methyl-prednisolone (MPZ) is one of the most common corticosteroids that caused allergic reactions (3, 4). This article is protected by copyright. All rights reserved.
December 31, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27992679/incomplete-and-incorrect-epinephrine-auto-injector-training-to-food-allergic-patients-by-pharmacists-in-the-netherlands
#6
J Saleh-Langenberg, S de Vries, E Bak, B J Kollen, B M J Flokstra-de Blok, A E J Dubois
BACKGROUND: Successful treatment of anaphylaxis in the community relies on early and correct use of epinephrine auto-injectors (EAI). In the Netherlands pharmacists supply EAIs to patients and have a crucial role in instructing patients in how and when to use EAI. However, there are currently no data in Europe on the quality of such instruction provided by pharmacists. Therefore, the aims of this study were to investigate the knowledge, attitudes, and beliefs regarding food allergy among pharmacists in the Netherlands, and to investigate the quality of EAI instructions and demonstrations to patients by pharmacists...
December 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27992668/extensively-hydrolyzed-casein-formula-alone-or-with-l-rhamnosus-gg-reduces-%C3%AE-lactoglobulin-sensitization-in-mice
#7
Rosita Aitoro, Raffaele Simeoli, Antonio Amoroso, Lorella Paparo, Rita Nocerino, Claudio Pirozzi, Margherita Di Costanzo, Rosaria Meli, Carmen De Caro, Gianluca Picariello, Gianfranco Mamone, Antonio Calignano, Cathryn R Nagler, Roberto Berni Canani
BACKGROUND: Extensively hydrolyzed casein formula (EHCF) has been proposed for the prevention and is commonly used for the treatment of cow's milk allergy (CMA). The addition of the probiotic Lactobacillus rhamnosus GG (LGG) to EHCF may induces faster acquisition of tolerance to cow's milk. The mechanisms underlying this effect are largely unexplored. We investigated the effects of EHCF alone or in combination with LGG on β-lactoglobulin (BLG) sensitization in mice. METHODS: Three-weeks old C3H/HeOuJ mice were sensitized by oral administration of BLG using cholera toxin as adjuvant at weekly intervals for 5 weeks (sensitization period)...
December 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27992662/parental-perception-of-their-child-s-quality-of-life-in-children-with-non-immunoglobulin-e-mediated-gastrointestinal-allergies
#8
R X Foong, R Meyer, H Godwin, R Dziubak, A C Lozinsky, K Reeve, R Knibb, N Shah
BACKGROUND: Food allergy can have a significant impact on health related quality of life (HRQoL). Parental proxy questionnaires are commonly used when children are too young to complete questionnaires themselves. Little data is available on HRQoL in children with non-IgE-mediated gastrointestinal food allergy (GIFA). The aim of this study was to evaluate HRQoL in these children by parent proxy. METHODS: A cross-sectional questionnaire study was conducted with children 2-16 years old with confirmed (GIFA)...
December 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27992659/a-systematic-review-of-serious-games-in-asthma-education
#9
David Drummond, Delphine Monnier, Antoine Tesnière, Alice Hadchouel
BACKGROUND: Serious games may be useful tools for asthma education. The objectives of this systematic review were to identify the available articles on serious games designed to educate patients and the general public about asthma and to assess their impact on patient's knowledge, behavior and clinical outcomes related to asthma. METHODS: PubMed, Embase, Cochrane Library, PsychInfo, and Web of Science were systematically searched from January 1980 to December 2015 for studies investigating serious games in asthma education...
December 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27893166/the-association-between-parental-consanguinity-and-primary-immunodeficiency-diseases-a-systematic-review-and-meta-analysis
#10
Hasti Hadizadeh, M Masoud Salehi, Shabnam Khoramnejad, Kia Vosoughi, Nima Rezaei
BACKGROUND: We aimed to establish the prevalence of parental consanguinity among patients with primary immunodeficiency diseases (PID), and compare the prevalence with the general population. METHOD: We searched PubMed, EMBASE, and Scopus for studies mentioning parental consanguinity prevalence in PID patients and calculated the prevalence odds ratio (POR) of parental consanguinity in each study, compared to a matched healthy population. RESULTS: We identified 21 eligible studies with a total population of 18091 accounting for sample overlap...
November 28, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27893162/late-onset-combined-immune-deficiency-due-to-ligiv-mutations-in-a-12-years-old-patient
#11
LETTER
Cristina Cifaldi, Giulia Angelino, Maria Chiriaco, Silvia Di Cesare, Alessia Claps, Jessica Serafinelli, Paolo Rossi, Antonio Antoccia, Gigliola Di Matteo, Caterina Cancrini, Jean Pierre De Villartay, Andrea Finocchi
The non-homologous end joining (NHEJ) pathway is involved in the repair of the DNA double-strand breaks. Defects in NHEJ factors result in IR sensitivity, and in defects in V(D)J recombination leading to immunodeficiency. DNA Ligase IV is an essential component that performs the final 'end processing' step of NHEJ. This article is protected by copyright. All rights reserved.
November 28, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27864894/maternal-dietary-intake-in-pregnancy-and-lactation-and-allergic-disease-outcomes-in-offspring
#12
REVIEW
Carina Venter, Kari R Brown, Kate Maslin, Debra J Palmer
As the prevalence of allergic disease dramatically rises worldwide, prevention strategies are increasingly being considered. Given the potential modulatory effect of nutritional factors on disease, altering maternal diet during pregnancy and/or lactation has been considered in preventing allergic disease in offspring. Though there are a number of observational studies that have examined possible associations between maternal diet and allergic outcomes in offspring, interventional trials are limited. Furthermore, there is a paucity of studies that have prospectively studied maternal dietary intake as well as measuring maternal and infant biological samples (blood, urine, breast milk) and their relation to allergic outcomes in infants...
November 19, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27801958/nasal-obstructive-disorders-induce-medical-treatment-failure-in-paediatric-persistent-allergic-rhinitis-the-nodpar-study
#13
Franklin S Mariño-Sánchez, Meritxell Valls-Mateus, Karen Ruiz-Echevarría, Isam Alobid, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Lozano-Blasco, María T Giner-Muñoz, Jesús Rodríguez-Jorge, Oliver Haag, Ana M Plaza-Martin, Joaquim Mullol
BACKGROUND: Allergic rhinitis (AR) is the most common chronic disease among children. To characterize the disease, a modified classification of severity (m-ARIA) has recently been validated in AR children. When medical treatment fails, surgery for nasal obstructive disorders (NOD) may be a therapeutic option. Our objective was to assess the prevalence of NOD and their influence in medical treatment response among children with persistent AR (PER). METHODS: In a prospective, real-life study, 130 paediatric PER patients (13...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27801950/use-of-the-control-of-allergic-rhinitis-and-asthma-test-caratkids-in-children-and-adolescents-validation-in-dutch
#14
J A M Emons, B M J Flokstra, C de Jong, T van der Molen, H K Brand, N J T Arends, R Amaral, J A Fonseca, R Gerth van Wijk
BACKGROUND: Allergic rhinitis and asthma are common and closely related diseases. Recently, a Portuguese questionnaire has been developed 'The Control of Allergic Rhinitis and Asthma Test' (CARATkids) that measures disease control of both diseases in children. This study aims to validate the CARATkids in Dutch children and for the first time in adolescents and, in addition, to calculate the minimal clinically important difference (MCID). METHODS: A prospective observational study was conducted in an outpatient clinic...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27801949/maternal-prenatal-stress-and-child-atopic-dermatitis-up-to-age-2-years-the-ulm-spatz-health-study
#15
Stefanie Braig, Johannes M Weiss, Tobias Stalder, Clemens Kirschbaum, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Evidence linking maternal psychosocial stress during pregnancy to subsequent child atopic dermatitis (AD) is growing, but the definition of AD is diverse and results are inconsistent. We aimed to analyze the relationship between stress and AD using alternative measurements of stress and AD. METHODS: In the Ulm SPATZ Health Study, chronic stress and symptoms of anxiety and depression were assessed by standardized self-reported questionnaires in 934 mothers of singletons following delivery in Ulm, Germany, from 04/2012-05/2013...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27797415/successful-desensitization-to-deferasirox-in-a-paediatric-patient-with-%C3%AE-thalassaemia-major
#16
LETTER
Grace Isobel Davies, Domenica Davies, Sarah Charles, Sara Laura Barnes, Donald Bowden
No abstract text is available yet for this article.
October 31, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27928877/editor-s-choice
#17
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27862336/asthma-and-allergic-rhinitis-in-childhood-what-s-new
#18
REVIEW
Carla Mastrorilli, Daniela Posa, Francesca Cipriani, Carlo Caffarelli
Novel approaches are currently offered for the diagnostic workup and therapeutic management of allergic rhinitis and asthma. New predictive biomarkers of allergy and asthma are available. Primary and secondary prevention, earlier intervention, and modification of the natural history of allergic rhinitis and asthma are being intensively investigated. This review highlights advances in the understanding of the etiology, diagnosis, and management of atopic airway diseases in childhood, as well as prenatal and early-life risk factors and strategies for prevention...
December 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27612945/comorbid-disorders-associated-with-asthma-in-children-in-germany-national-analysis-of-pediatric-primary-care-data
#19
Louis Jacob, Thomas Keil, Karel Kostev
BACKGROUND: Using routine healthcare data, the goal of this study was to examine the association between asthma and comorbid disorders in children in Germany. METHODS: Patients with a diagnosis of asthma documented by a German pediatrician in 2015 were identified. Demographic data included age and gender. Patients younger than 6 and older than 17 and individuals followed for less than a year before index date were excluded. Each patient was matched for age, sex, and physician with an asthma-free control...
December 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27612327/allergic-rhinitis-causes-loss-of-smell-in-children-the-olfapedrial-study
#20
Cristóbal Langdon, José María Guilemany, Meritxell Valls, Isam Alobid, Joan Bartra, Ignacio Dávila, Alfonso Del Cuvillo, Marta Ferrer, Ignacio Jáuregui, Javier Montoro, Joaquín Sastre, Antonio Valero, Joaquim Mullol
BACKGROUND: The objective of the OLFAPEDRIAL study was to assess the olfactory dysfunction in allergic paediatric population, which has been scarcely studied. METHODS: Observational, cross-sectional and multicentre study evaluated the sense of smell in untreated allergic rhinitis (AR) paediatric patients aged 6-12 years. RESULTS: Forty-four per cent (551 of 1260) of children with AR reported smell dysfunction, with both loss of smell frequency (52...
December 2016: Pediatric Allergy and Immunology
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