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Pediatric Allergy and Immunology

Lone Graff Stensballe, Lotte Klansø, Andreas Jensen, Ann Haerskjold, Simon Francis Thomsen, Jacob Simonsen
BACKGROUND: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated...
June 20, 2017: Pediatric Allergy and Immunology
Inês Pádua, André Moreira, Patrícia Padrão, Pedro Moreira, Renata Barros
Food allergy (FA) has a significant impact on patients and families 'quality of life ((1)) and, considering that traveling is particularly anxiety provoking for children ((2)) , many parents prefer to minimize the risk induced by such activities by avoiding them altogether ((3)) . This article is protected by copyright. All rights reserved.
June 20, 2017: Pediatric Allergy and Immunology
Myongsoon Sung, Kyung Suk Lee, Eun Gyo Ha, Seung Jin Lee, Mi Ae Kim, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Young Ho Jung, Man Yong Han
BACKGROUND: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Of the 4,076 children, 196 including 137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group were included for the final analysis...
June 20, 2017: Pediatric Allergy and Immunology
Young-Min Kim, Jihyun Kim, Ji Young Lee, Minji Kim, Hyunmi Kim, Kwon Jung, Soomi Eo, Mijin Ahn, Kangmo Ahn
BACKGROUND: There are controversial data about the effects of sun exposure on atopic dermatitis (AD). We evaluated the association between solar ultraviolet radiation (UVR) exposure and AD symptoms in children. METHODS: Eighty two children under 6 years (48 boys and 34 girls) with AD living in Seoul, Korea were enrolled and followed for 12 months between September 2013 and August 2014. Daily symptoms were recorded to describe the degree of itching, sleep disturbance, erythema, dryness, oozing and edema...
June 20, 2017: Pediatric Allergy and Immunology
Marie Lagreula, Anca-Mirela Chiriac, Maria Chiara Leoni, Pascal Demoly, Davide Caimmi
Prevalence of both asthma and food allergy is increasing in Western Europe (1,2). In France, according to recent surveys, the prevalence of asthma is 9.4% in children and 7% in adults (3). Food allergy proven by oral food challenges (OFC) affects between 1 to 10% of the population (4). Studies have been considering both disorders as comorbidities under the atopic disease concept. Asthmatic children with food allergy have an increased risk for asthma exacerbation and severe asthma, especially when developing anaphylactic reactions (1,5)...
June 20, 2017: Pediatric Allergy and Immunology
Francesca Mori, Lucia Fili, Simona Barni, Lucrezia Sarti, Alessandra Montemaggi, Andrea Bassi, Cesare Filippeschi, Luisa Galli, Paola Parronchi, Elio Novembre
Stevens-Johnson syndrome (SJS) is a rare life-threatening condition attributed almost exclusively to drug exposure (1). The main etiologic factor for SJS is treatment with drugs, primarily sulfonamides and anticonvulsants, followed by penicillins and non-steroidal anti-inflammatory drugs (1). Among penicillins, amoxicillin/clavulanic acid (AMX/CLV), despite generally being a well-tolerated antimicrobial, has been reported as a risk factor for SJS in adults and children in several publications (2, 3). This article is protected by copyright...
June 9, 2017: Pediatric Allergy and Immunology
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are however conflicting opinions as to whether there are differences in response to RV infection or if wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
June 9, 2017: Pediatric Allergy and Immunology
Maxwell M Tran, Diana L Lefebvre, David Dai, Christoffer Dharma, Padmaja Subbarao, Wendy Lou, Meghan B Azad, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The effect of infant feeding practices on the development of food allergy remains controversial. We examined the relationship between timing and patterns of food introduction and sensitization to foods at age 1 year in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. METHODS: Nutrition questionnaire data prospectively collected at age 3, 6, 12, 18 and 24 months were used to determine timing of introduction of cow's milk products, egg and peanut...
May 29, 2017: Pediatric Allergy and Immunology
Chiara Sacco, Serena Perna, Donatella Vicari, Marco Alfò, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: Previous studies of serum total IgE (t-IgE) were not able to discriminate well enough atopic from non-atopic subjects, i.e. with or without serum-specific IgE antibodies to allergens. OBJECTIVES: To model growth curves of the total IgE levels in children without atopic sensitization (hereafter defined as "normal" t-IgE levels) and to test their usefulness in predicting atopic sensitization. METHODS: The German Multicentre Allergy Study (MAS), a birth cohort with 1314 recruited newborns, began in 1990 and examined the participants until age 20y...
May 25, 2017: Pediatric Allergy and Immunology
Satomi Mori, Shuntaro Tsumagari, Kazuyuki Kurihara
Fermented soybean (natto) is a traditional food in Japan. Because natto is rich in vitamin K2, it affects both thrombolysis and bone metabolism and has been widely marketed throughout the world as a health food. Most people with a soybean allergy can safely consume fermented soybean products such as miso (soybean paste), soy sauce, and natto because the fermentation process weakens the immunoreactivity of the soybean protein.(1) Nevertheless, there had been several reports of natto-induced late-onset anaphylaxis in adults...
May 22, 2017: Pediatric Allergy and Immunology
Francesca Occasi, Marzia Duse, Marcella Nebbioso, Giovanna De Castro, Marco Di Fraia, Giulia Capata, Valeria Lollobrigida, Anna Maria Zicari
We report the cases of 4 children affected by Vernal keratoconjunctivitis (VKC) treated with Omalizumab with resolution of ocular signs and symptoms. Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis, not responding to topical antihistamines and frequently misdiagnosed and mistreated. This article is protected by copyright. All rights reserved.
May 22, 2017: Pediatric Allergy and Immunology
Lorenzo Lodi, Silvia Ricci, Francesca Romano, Federica Ghiori, Clementina Canessa, Francesca Lippi, Leila Bianchi, Chiara Azzari
Tuscany is the first region in Italy to have implemented a neonatal screening for congenital immunodeficiencies using both tandem mass spectrometry for early and late-onset adenosine deaminase and purine-nucleoside phosphorylase deficiency (1) and multiplex Real-Time PCR for TREC and KREC quantification on Dried Blood Spots (DBS) (2). The screening program with TREC and KREC started on December 2013 and, basing on the last data update of March 2017, it has screened a total of 18981 newborns in these first 3 years...
May 18, 2017: Pediatric Allergy and Immunology
Daniel Tegtmeyer, Maximilian Seidl, Patrick Gerner, Ulrich Baumann, Christian Klemann
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases has been described to present often primarily, or solely as IBD. Early recognition of these conditions enables adaption of therapies and thus directly benefits the course of IBDs...
May 17, 2017: Pediatric Allergy and Immunology
Gholamreza Azizi, Hassan Abolhassani, Seyed Alireza Mahdaviani, Zahra Chavoshzadeh, Peyman Eshghi, Reza Yazdani, Fatemeh Kiaee, Mohammadreza Shaghaghi, Javad Mohammadi, Nima Rezaei, Lennart Hammarström, Asghar Aghamohammadi
BACKGROUND: LPS-responsive beige-like anchor protein (LRBA) deficiency is a combined immunodeficiency caused by mutation in LRBA gene. The patients have a variety of clinical symptoms including hypogammaglobulinemia, recurrent infections, autoimmunity and enteropathy. METHODS: A total of 17 LRBA-deficient patients were enrolled in this longitudinal study. For all patients, demographic information, clinical records, laboratory and molecular data were collected. RESULTS: Hypogammaglobulinemia were reported in 14 (82...
May 17, 2017: Pediatric Allergy and Immunology
Laura Polloni, Sami Schiff, Emilia Ferruzza, Francesca Lazzarotto, Roberta Bonaguro, Alice Toniolo, Nicolò Celegato, Muraro Antonella
BACKGROUND: Food allergy is a common immunological disease that includes potentially fatal reactions. It impacts considerably on patients' social life including close interpersonal relationships. Attachment theory provides a theoretical framework to evaluate the quality of close interpersonal relationships in chronic disorders. Attachment insecurity, mainly characterized by attachment avoidance, has been found in a variety of health conditions, but still needs to be investigated in food allergy...
May 8, 2017: Pediatric Allergy and Immunology
Carolina Sanchez Aranda, Kelly Pereira, Helena Velasco, Marcia Mallozi, Roseani Andrade, Wellington Rodrigues, João Bosco Pesquero, Ana Maria Martins, Dirceu Solé
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, especially during childhood, with an estimated prevalence of 11% in Latin America (1). The complexity of AD clinical phenotypes occurs due to the existence of different physiopathological pathways for the illness, including changes in innate and adaptive immune responses, skin barrier dysfunction and allergic sensitization (2). This article is protected by copyright. All rights reserved.
May 5, 2017: Pediatric Allergy and Immunology
Evelyn Xiu Ling Loo, Jordan Zheng Ting Sim, Jia Ying Toh, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Kok Hian Tan, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Mary Foong-Fong Chong, Lynette Pei-Chi Shek
Allergic disorders result from the complex interplay between genetic predisposition and environmental influences. According to the Developmental Origins of Health and Disease hypothesis, environmental pressures at critical or early periods of development can evoke persisting changes in gene regulation and expression (1), affecting disease development. Infant nutrition is a major environmental influence in early life as the immature gut is exposed to a variety of food proteins. However, results from studies examining the early introduction of allergenic food and allergic outcomes have been conflicting...
April 27, 2017: Pediatric Allergy and Immunology
Mariana Couto, Corália Barbosa, Diana Silva, Alisa Rudnitskaya, Luís Delgado, André Moreira, Sílvia M Rocha
We hypothesize that oxidative stress induced by trichloramine exposure during swimming could be related to etiopathogenesis of asthma among elite swimmers. AIM: To investigate the effect of a swimming training session on oxidative stress markers of asthmatic compared to non-asthmatic elite swimmers using exhaled breath (EB) metabolomics. METHODS: Elite swimmers annually screened in our department (n=27) were invited and those who agreed to participate (n=20, of which 9 with asthma) had EB collected (Tedlar(®) bags) before and after a swimming training session...
April 27, 2017: Pediatric Allergy and Immunology
Şeyhan Kutluğ, Mehtap Kılıç, Birşen Bilgici, Şule Paksu, Alişan Yıldıran, Recep Sancak
BACKGROUND: Serum vitamin D levels have not been studied in children with seasonal allergic rhinitis (SAR). The aim of this study was to evaluate the vitamin D levels of children with SAR and to compare them to levels in healthy children during pollen season. METHODS: This study was conducted in 100 children with SAR and 100 healthy controls. Clinical and laboratory evaluations and vitamin D analyses of all the participants were performed between the months of April and July...
April 27, 2017: Pediatric Allergy and Immunology
Meritxell Valls-Mateus, Franklin Marino-Sanchez, Karen Ruiz-Echevarría, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Blasco-Lozano, María Teresa Giner-Muñoz, Oliver Haag, Isam Alobid, Ana María Plaza Martin, Joaquim Mullol
BACKGROUND: We previously reported a higher prevalence of nasal obstructive disorders (NOD) in pediatric patients with persistent allergic rhinitis (PER) not responding to medical treatment. The aim of this study was to determine the impact of NOD on quality of life (QoL) in this population. METHODS: Real-life prospective study including 142 patients (41 children, 6-11 yo and 101 adolescents, 12-17 yo) with moderate and severe PER. After two months of medical treatment (intranasal steroids and antihistamines) patients were asked if their symptoms had improved (yes/no) and classified accordingly in R, responders and NR, non-responders...
April 19, 2017: Pediatric Allergy and Immunology
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