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Pediatric Allergy and Immunology

Aharon Kessel, Henriette Farkas, Shmuel Kivity, Nóra Veszeli, Kinga Viktória Kőhalmi, Batya Engel-Yeger
BACKGROUND: The severe life-threatening characteristics of hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) can affect anxiety levels among pediatric patients. This emotional burden together with the physical restrictions of C1-INH-HAE may decrease children's health-related quality of life (HRQoL). OBJECTIVE: (1) To compare anxiety state and trait between children with C1-INH-HAE and healthy controls (2) To examine the relationship between the level of anxiety of children with C1-INH-HAE, their disease activity/affected sites and their HRQoL (3) To predict the HRQoL of children with C1-INH-HAE based on their anxiety level and disease activity/affected sites...
July 10, 2017: Pediatric Allergy and Immunology
Gustavo J Rodrigo, Hugo Neffen
BACKGROUND: Recently published data support the benefits and safety of the once-daily (OD) long-acting anticholinergic tiotropium bromide bronchodilator for the treatment of uncontrolled moderate to severe asthma in adults and adolescents. However, its role for the treatment of school-age asthmatics has not yet been clearly defined. The aim of this systematic review was to assess the efficacy and safety of tiotropium Respimat(®) in children aged 6-11 years with moderate to severe symptomatic asthma...
July 10, 2017: Pediatric Allergy and Immunology
Volker Wahn, Horst von Bernuth
The chance to analyze the four IgG subclasses arose with the publication of Terry WD and Fahey JL (1964). Since then a lot of new information on the role of subclasses and their deficiency states in humans has been obtained. This review tries to analyze critically our current knowledge of subclass deficiencies in children. This article is protected by copyright. All rights reserved.
July 7, 2017: Pediatric Allergy and Immunology
Meredith A Dilley, Carter R Petty, William J Sheehan, Jonathan M Gaffin, Marissa Hauptman, Wanda Phipatanakul
Asthma is the most common chronic disease in children, (1) with many modifiable risk factors impacting asthma morbidity, including adherence to medications. Despite research demonstrating the importance of adherence to asthma medication regimens, poor and variable adherence persists,(2) with patients receiving 30-70% of prescribed doses of inhaled corticosteroids.(3) Non-adherence may be especially prevalent in minorities and those of lower socioeconomic status, which may contribute to higher morbidity in these groups...
July 7, 2017: Pediatric Allergy and Immunology
Kirsten I M Looman, Michelle A E Jansen, Trudy Voortman, Diana van den Heuvel, Vincent W V Jaddoe, Oscar H Franco, Menno C van Zelm, Henriëtte A Moll
BACKGROUND: Previous studies have demonstrated that vitamin D affects T cell function and maturation via the vitamin D receptor. However, no studies in children have been performed on this topic. Because most of the T cell memory is formed in the first five years of life, we aimed to determine the association between serum 25-hydroxyvitamin D (25(OH)D) levels and numbers of circulatory naive, central memory (Tcm) and effector memory (Tem) T lymphocytes in a large population of healthy children...
July 7, 2017: Pediatric Allergy and Immunology
Christian J Apfelbacher, Daniel Heinl, Helen E Smith
There is a current paradigm shift to the inclusion of patient-reported outcome measures (PROMs), such as health-related quality of life or functioning, in clinical trials and evaluative healthcare research. Before incorporating PROMS into studies it is important to review their qualities and characteristics objectively. It is for this reason we welcome Soyiri et al.'s review of PROMs for children with asthma and allergy. This article is protected by copyright. All rights reserved.
July 7, 2017: Pediatric Allergy and Immunology
Wilfredo Cosme-Blanco, Eduardo Lopez, Sylvia Morales-Bronner, William Blouin, Vivian Hernandez-Trujillo
Pet allergens follow aeroallergens as a common cause of asthma and rhinitis in children (1,2). Specifically, cat and dog dander are typical triggers of these symptoms(1). However, high percent of patients with severe asthma can be sensitized to other mammals, such as horses and mice(3). This is not limited to occupational or rural areas where exposure to this animal is more prevalent. A high rate of sensitization to horses in people with no known direct exposure who live in urban areas is well documented(4)...
July 7, 2017: Pediatric Allergy and Immunology
Ali Arabkhazaeli, Susanne J H Vijverberg, Cornelis K van der Ent, Jan A M Raaijmakers, Anke H Maitland-van der Zee
Asthma medicines (e.g. inhaled corticosteroids (ICS) and inhaled β-agonists) are the most commonly chronically used medication in children.(1) In the Netherlands, asthma is treated according to a stepwise approach, which is mainly derived from the British Thoracic Society (BTS) guidelines.(2, 3) The guidelines advice to start treatment at the most appropriate step according to clinical severity. Step up of asthma treatment is advised if a child does not reach asthma control in the current step, and step down is advised if a child is well controlled for a period of 3 months...
June 29, 2017: Pediatric Allergy and Immunology
Tomokazu Matsuoka, David I Bernstein, Keisuke Masuyama, Hendrik Nolte, Kazuhiro Okamiya, Dorthe Seitzberg, Harold S Nelson
BACKGROUND: House dust mite (HDM) respiratory allergy is a common and burdensome disease in children and adolescents. There are few HDM allergy immunotherapy trials in children with perennial allergic rhinitis. This post hoc analysis used pooled data to evaluate efficacy and safety of the SQ HDM sublingual immunotherapy (SLIT) tablet in adolescents (12-17 years). METHODS: In 2 double-blind, placebo-controlled trials conducted in North America and Japan, respectively, subjects aged 12+ years with HDM allergic rhinitis were randomized to up to one year of treatment...
June 29, 2017: Pediatric Allergy and Immunology
Annamari Koistinen, Minna Lukkarinen, Riitta Turunen, Tytti Vuorinen, Tero Vahlberg, Carlos A Camargo, James Gern, Olli Ruuskanen, Tuomas Jartti
BACKGROUND: Previous findings show that corticosteroid treatment during the first acute wheezing episode may reduce recurrent wheezing in children with high rhinovirus genome load at 12-month follow-up. Longer-term effects have not been investigated prospectively. METHODS: After PCR-confirmation of rhinovirus from nasopharyngeal aspirate, 79 children with the first acute wheezing episode were randomized to receive orally prednisolone or placebo for three days. The initiation of asthma control medication before the age of 5 years was confirmed from medical record and/or from parental interview...
June 29, 2017: Pediatric Allergy and Immunology
Nivita Divya Sharma
BACKGROUND: Several explanations for the inconsistent results on the effects of breastfeeding on childhood asthma have been suggested. The purpose of this study is to investigate one unexplored explanation, which is the presence of a potential endogenous relationship between breastfeeding and childhood asthma. Endogeneity exists when an explanatory variable is correlated with the error term for reasons such as selection bias, reverse causality, and unmeasured confounders. Unadjusted endogeneity will bias the effect of breastfeeding on childhood asthma...
June 29, 2017: Pediatric Allergy and Immunology
Lisbeth Marianne Thøstesen, Henrik Fomsgaard Kjaer, Gitte Thybo Pihl, Thomas Nørrelykke Nissen, Nina Marie Birk, Jesper Kjaergaard, Aksel Karl Georg Jensen, Peter Aaby, Annette Wind Olesen, Lone Graff Stensballe, Dorthe Lisbeth Jeppesen, Christine Stabell Benn, Poul-Erik Kofoed
BACKGROUND: Vaccination with Bacillus Calmette-Guérin (BCG) is used in many countries as protection against tuberculosis. Studies have suggested that BCG may also have non-specific effects, reducing non-tuberculosis mortality, morbidity, and atopic manifestations. In this study we evaluated the effect of neonatal BCG vaccination on allergic sensitization and suspected food allergy at 13 months of age. METHODS: The Danish Calmette Study was conducted from 2012-2015 at three Danish hospitals...
June 29, 2017: Pediatric Allergy and Immunology
Lone Graff Stensballe, Lotte Klansø, Andreas Jensen, Ann Haerskjold, Simon Francis Thomsen, Jacob Simonsen
BACKGROUND: The incidence of atopic dermatitis, wheezing, asthma and allergic rhinoconjunctivitis have been increasing. Register-based studies are essential for research in subpopulations with specific diseases, and facilitate epidemiological studies to identify causes and evaluate interventions. Algorithms have been developed to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis using register information on disease-specific dispensed prescribed medication and hospital contacts, but the validity of the algorithms has not been evaluated...
June 20, 2017: Pediatric Allergy and Immunology
Inês Pádua, André Moreira, Patrícia Padrão, Pedro Moreira, Renata Barros
Food allergy (FA) has a significant impact on patients and families 'quality of life ((1)) and, considering that traveling is particularly anxiety provoking for children ((2)) , many parents prefer to minimize the risk induced by such activities by avoiding them altogether ((3)) . This article is protected by copyright. All rights reserved.
June 20, 2017: Pediatric Allergy and Immunology
Myongsoon Sung, Kyung Suk Lee, Eun Gyo Ha, Seung Jin Lee, Mi Ae Kim, Seung Won Lee, Hye Mi Jee, Youn Ho Shin, Young Ho Jung, Man Yong Han
BACKGROUND: Serum periostin might be a biomarker of the pathogenesis of T helper 2-type allergic diseases. The aim of this study is to investigate the relationship between serum periostin levels and the severity and chronicity of atopic dermatitis (AD) in children. METHODS: This population-based study examined 4,076 children from aged 4 to 13 years between June 2015 and July 2015. Of the 4,076 children, 196 including 137 with a history of AD in the AD group and 59 without allergic diseases history in the healthy control (HC) group were included for the final analysis...
June 20, 2017: Pediatric Allergy and Immunology
Young-Min Kim, Jihyun Kim, Ji Young Lee, Minji Kim, Hyunmi Kim, Kwon Jung, Soomi Eo, Mijin Ahn, Kangmo Ahn
BACKGROUND: There are controversial data about the effects of sun exposure on atopic dermatitis (AD). We evaluated the association between solar ultraviolet radiation (UVR) exposure and AD symptoms in children. METHODS: Eighty two children under 6 years (48 boys and 34 girls) with AD living in Seoul, Korea were enrolled and followed for 12 months between September 2013 and August 2014. Daily symptoms were recorded to describe the degree of itching, sleep disturbance, erythema, dryness, oozing and edema...
June 20, 2017: Pediatric Allergy and Immunology
Marie Lagreula, Anca-Mirela Chiriac, Maria Chiara Leoni, Pascal Demoly, Davide Caimmi
Prevalence of both asthma and food allergy is increasing in Western Europe (1,2). In France, according to recent surveys, the prevalence of asthma is 9.4% in children and 7% in adults (3). Food allergy proven by oral food challenges (OFC) affects between 1 to 10% of the population (4). Studies have been considering both disorders as comorbidities under the atopic disease concept. Asthmatic children with food allergy have an increased risk for asthma exacerbation and severe asthma, especially when developing anaphylactic reactions (1,5)...
June 20, 2017: Pediatric Allergy and Immunology
Francesca Mori, Lucia Fili, Simona Barni, Lucrezia Sarti, Alessandra Montemaggi, Andrea Bassi, Cesare Filippeschi, Luisa Galli, Paola Parronchi, Elio Novembre
Stevens-Johnson syndrome (SJS) is a rare life-threatening condition attributed almost exclusively to drug exposure (1). The main etiologic factor for SJS is treatment with drugs, primarily sulfonamides and anticonvulsants, followed by penicillins and non-steroidal anti-inflammatory drugs (1). Among penicillins, amoxicillin/clavulanic acid (AMX/CLV), despite generally being a well-tolerated antimicrobial, has been reported as a risk factor for SJS in adults and children in several publications (2, 3). This article is protected by copyright...
June 9, 2017: Pediatric Allergy and Immunology
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are however conflicting opinions as to whether there are differences in response to RV infection or if wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
June 9, 2017: Pediatric Allergy and Immunology
Maxwell M Tran, Diana L Lefebvre, David Dai, Christoffer Dharma, Padmaja Subbarao, Wendy Lou, Meghan B Azad, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The effect of infant feeding practices on the development of food allergy remains controversial. We examined the relationship between timing and patterns of food introduction and sensitization to foods at age 1 year in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study. METHODS: Nutrition questionnaire data prospectively collected at age 3, 6, 12, 18 and 24 months were used to determine timing of introduction of cow's milk products, egg and peanut...
May 29, 2017: Pediatric Allergy and Immunology
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