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Pediatric Allergy and Immunology

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https://www.readbyqxmd.com/read/29117431/food-allergy-and-atopic-dermatitis-prediction-progression-and-prevention
#1
REVIEW
Carla Mastrorilli, Carlo Caffarelli, Karin Hoffmann-Sommergruber
The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depends on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution and infections. Preventive strategies may include avoidance measures, diet supplements and early complementary food introduction...
November 8, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29068159/sputum-tweak-expression-correlates-with-severity-and-degree-of-control-in-noneosinophilic-childhood-asthma
#2
Soo Yeon Kim, Jong Deok Kim, In Suk Sol, Min Jung Kim, Mi Na Kim, Jung Yeon Hong, Hye Ran Kim, Yoon Hee Kim, Yong Ju Lee, Kyung Won Kim, Myung Hyun Sohn
BACKGROUND: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is known to play a role in the pathogenesis of various inflammatory diseases. However, no study has been performed on childhood asthma. METHODS: Ninety-five children with asthma and 78 controls aged 5-18 years were included. Sputum induction, pulmonary function test (PFT), and methacholine challenge test were performed. The subjects were divided into the eosinophilic airway (EA) and non-EA (NEA) groups based on sputum analysis and into the high and low TWEAK groups according to the TWEAK cutoff level (263...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29068090/early-introduction-of-allergenic-foods-for-the-prevention-of-food-allergy-from-an-asian-perspective-an-apapari-consensus-statement
#3
REVIEW
E H Tham, L P Shek, H P Van Bever, P Vichyanond, M Ebisawa, G W K Wong, B W Lee
Emerging evidence for the early introduction of allergenic foods for the prevention of food allergies, such as peanut allergy in Western populations, has led to the recent publication of guidelines in the US and Europe recommending early peanut introduction for high-risk infants with severe eczema or egg allergy. Peanut allergy is, however, much less prevalent in Asia compared to the West. Varying patterns of food allergy are seen even within Asian countries - such as a predominance of wheat allergy in Japan and Thailand and shellfish allergy in Singapore and the Philippines...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29067711/food-allergy-in-eaaci-journals-2016
#4
REVIEW
Ulrich Wahn, Paolo M Matricardi, Thomas Bieber, Jean Bousquet, Clive Grattan, Hans-Uwe Simon, Antonella Muraro, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to understand and better manage food allergy, and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members (1). The European Symposium on Precision Medicine in Allergy and Airways Diseases at the European Union Parliament (October 14, 2015) stressed that the socioeconomic impact of food allergy (2)...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047183/follow-up-of-patients-with-uncertain-symptoms-during-an-oral-food-challenge-is-useful-for-diagnosis
#5
Taro Miura, Noriyuki Yanagida, Sakura Sato, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Uncertain symptoms often emerge during an oral food challenge (OFC) and Open-OFCs with those uncertain mild symptoms are ordinarily regarded as positive. Double-blind placebo-controlled food challenges should be conducted in order to determine these associations. Nevertheless, studies regarding the diagnosis of uncertain food allergy symptoms are lacking. We examined the diagnostic decision for a food allergy based on uncertain symptoms during an Open-OFC. METHODS: We conducted an Open-OFC between August 2005 and April 2012 with 2271 cases who suspected as allergic to hen's eggs, cow's milk, or wheat...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047178/the-effect-of-montelukast-on-early-life-wheezing-a-randomized-double-blinded-placebo-controlled-study
#6
Ozlem Keskin, Ebru Arik Yilmaz, Christine Motzkus, Cansin Sackesen, Craig M Lilly, Omer Kalayci
BACKGROUND: Cysteinyl-leukotrienes are increased in the airways of infants with virus-associated wheezing. We aimed to determine the effects of a cysteinyl-leukotriene-1 receptor antagonist on symptoms during an early-life wheezing illness and to investigate the factors that affect the response to this drug. METHOD: This placebo-controlled double-blinded randomized controlled trial recruited children aged 3-36 months with wheezing illness and randomized to active drug or placebo for 56 days...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047176/increase-in-atopic-sensitization-rate-among-dutch-children-with-symptoms-of-allergic-disease-between-1994-and-2014
#7
Lukas B M Koet, Paul L P Brand
BACKGROUND: The prevalence of symptoms of allergic diseases has increased significantly during the last decades. However, studies into time trends of atopic sensitization among children are limited and have focused on aeroallergen sensitization. We aimed to investigate time trends in the prevalence and degree of atopic sensitization to inhalant and food allergens among children (0-17 years) with symptoms of allergic disease. METHODS: Sensitization data of all children tested in our clinical laboratory during 1994-2014 were analyzed...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047174/pediatric-allergy-and-immunology-in-china
#8
REVIEW
Gary Wk Wong, Jing Li, Yi-Xiao Bao, Jiu-Yao Wang, Ting Fan Leung, Luan-Luan Li, Jie Shao, Xin-Yuan Huang, En-Mei Liu, Shen Kun-Ling, Chen Yu-Zhi
Over the past thirty years, China has enjoyed rapid economic development along with urbanization at a massive scale that the world has not experienced before. Such development has also been associated with a rapid rise in the prevalence of allergic disorders. Because of the large childhood population in the country, the burden of childhood allergic disorders has become one of the major challenges in the health care system. Among the Chinese centers participating in the International Study of Asthma and Allergies in Childhood clearly, the data showed a continuing rise in the prevalence of asthma, allergic rhinitis and atopic eczema...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047172/fatal-anaphylaxis-in-children-in-france-analysis-of-national-data
#9
LETTER
Guillaume Pouessel, Luciana Kase Tanno, Claire Claverie, Stéphanie Lejeune, Julien Labreuche, Aimée Dorkenoo, Jean-Marie Renaudin, Mireille Eb, Stéphane Leteurtre, Antoine Deschildre
Anaphylaxis is a recognized cause of death for all ages. A better understanding of mortality data could help identify patients at risk and implement prevention measures. However, accurate epidemiological mortality data can differ widely due to a number of variables. Currently, the anaphylaxis-related mortality rate (AMR) is less than 1 per million population per year in most countries. In France, it was 0.83 per million population per year (95%CI, 0.80-0.88) for the period 1979 to 2011 (1-6). This article is protected by copyright...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047170/irf-1-snps-influence-the-risk-for-childhood-allergic-asthma-a-critical-role-for-pro-inflammatory-immune-regulation
#10
Katja Landgraf-Rauf, Andreas Boeck, Diana Raedler, Elisabeth Klucker, Vanessa Vogelsang, Susanne Schmidt, Sonja Kunze, Claudia Weissenbacher, Anke Graessel, Carsten Schmidt-Weber, Erika von Mutius, Michaela Schedel, Bianca Schaub
BACKGROUND: Allergic and non-allergic childhood asthma has been characterized by distinct immune mechanisms. While interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) influence atopy risk, the effect of SNPs on asthma phenotype-specific immune mechanisms is unclear. We assessed whether IRF-1 SNPs modify distinct immune regulatory pathways in allergic and non-allergic childhood asthma (AA/NA). METHODS: In the CLARA study, asthma was characterized by doctor's diagnosis and AA vs NA by positive or negative specific IgE...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047169/non-immediate-reading-skin-tests-and-prolonged-challenges-in-non-immediate-hypersensitivity-to-beta-lactams-in-children
#11
G Lezmi, F Alrowaishdi, A Bados-Albiero, P Scheinmann, J de Blic, C Ponvert
BACKGROUND: A minority of children reporting non-immediate reactions to beta-lactams (BLs) are allergic. Allergy workup usually includes late-reading (48-72h) skin tests (ST) and short (1-3 days) drug provocation tests (DPT), regardless of the chronology of the index reaction. The sensitivity of hyper-late-reading (≥ 6-7 days) ST and of prolonged DPT for the diagnosis of non-immediate hypersensitiviy to BLs are yet to be determined. OBJECTIVES: To establish the diagnostic values of late- and hyper-late-reading ST and of prolonged DPT in children reporting non-immediate reactions to BLs...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047167/the-association-between-an-genetic-risk-score-for-allergy-and-the-risk-of-developing-allergies-in-childhood-results-of-the-whistler-cohort
#12
Ali Arabkhazaeli, Fariba Ahmadizar, Maarten Leusink, Hubertus G M Arets, Jan A M Raaijmakers, Cuno S Uiterwaal, Cornelis K van der Ent, Anke-Hilse Maitland-van der Zee, Susanne J H Vijverberg
BACKGROUND: Several genetic variants have been associated with the susceptibility to allergic disease in adults, but it remains unclear whether these genetic variants are also associated with the onset of allergic disease early in life. The aim of this study was to develop a genetic risk score (GRS) for allergy based on findings in adults and study its predictive capacity for allergy in children. METHODS: A GRS was constructed based on 10 SNPs previously associated with allergies in adults...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047164/multifocal-fixed-drug-eruption-to-ceftazidime-in-a-child-with-cystic-fibrosis
#13
LETTER
Asma Ben Mansour, Nathalia Bellon, Annonciade Frassati-Biaggi, Isabelle Sermet-Gaudelus, Claude Ponvert, Jacques de Blic, Guillaume Lezmi
Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by well-delimited pigmented lesions of the skin and/or mucosa [1,2]. FDE is rare and frequently misdiagnosed leading to recurrent eruptions after the offending drug is re-administered [1,2]. The diagnosis hallmark is its recurrence in previously affected sites leading to a residual hyperpigmentation, however some cases without residual pigmentation have been described [2]. Many drugs have been shown to induce FDE, especially antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) [3]...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29044803/impact-of-pediatric-obesity-on-acute-asthma-exacerbation-in-japan
#14
Yusuke Okubo, Nobuaki Michihata, Koichi Yoshida, Naho Morisaki, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: Asthma and obesity are common health problems in children. This study investigated the impact of obesity on children hospitalized with acute asthma exacerbation. METHODS: We obtained the hospital discharge records of inpatients aged 3-8 years with a diagnosis of asthma using a national inpatient database in Japan. The patients were classified into underweight, normal weight, overweight, and obese groups using weight for height and body mass index for age provided by the World Health Organization...
October 18, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29024078/fruit-intake-reduces-the-onset-of-respiratory-allergic-symptoms-in-schoolchildren
#15
Takashi Kusunoki, Jiro Takeuchi, Takeshi Morimoto, Mio Sakuma, Takahiro Yasumi, Ryuta Nishikomori, Akane Higashi, Toshio Heike
BACKGROUND: Previous studies have shown that dietary pattern is associated with allergy prevention. METHODS: We conducted a prospective cohort study on all primary schools in Omihachiman City, Shiga Prefecture, Japan. Questionnaires regarding allergic symptoms and diet were distributed to the parents of all 759 7-year-old schoolchildren for 4 consecutive years, from 2011-2014. Specific immunoglobulin E to inhalant allergens were measured at 10 years of age. Participants were then categorized as low, medium, or high intake during the study period for four food groups (fruits, vegetables, fish and beans)...
October 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28986924/physician-s-appraisal-versus-documented-signs-and-symptoms-in-the-interpretation-of-food-challenge-tests-the-europrevall-birth-cohort
#16
Linus B Grabenhenrich, Andreas Reich, Doreen McBride, Aline Sprikkelman, Graham Roberts, Kate E C Grimshaw, Alessandro G Fiocchi, Photini Saxoni-Papageorgiou, Nikolaos G Papadopoulos, Ana Fiandor, Santiago Quirce, Marek L Kowalski, Sigurveig T Sigurdardottir, Ruta Dubakiene, Jonathan O B Hourihane, Leonard Rosenfeld, Bodo Niggemann, Thomas Keil, Kirsten Beyer
BACKGROUND: Blinded food challenges are considered the current gold standard for the diagnosis of food allergies. We used data from a pan-European multicentre project to assess differences between study centres, aiming to identify the impact of subjective aspects for the interpretation of oral food challenges. METHODS: Nine study centres of the EuroPrevall birth cohort study on food allergy recruited 12,049 newborns and followed them for up to 30 months in regular intervals...
October 6, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28986919/mepolizumab-a-novel-option-for-the-treatment-of-hypereosinophilic-syndrome-in-childhood
#17
Carsten Schwarz, Thilo Müller, Susanne Lau, Kirn Parasher, Doris Staab, Ulrich Wahn
BACKGROUND: Mepolizumab was originally intended as a therapeutic agent for atopic asthma in adults, and consequently little is known about its use in children. Up to now corticosteroids have formed the basis of the initial treatment of hypereosinophilic syndromes and are shown to be effective in most patients. To analyse the effect of mepolizumab in children is the aim of this study. METHODS: We are reporting the experience of the effect of mepolizumab in two paediatric patients of hypereosinophilic syndrome that was not sufficiently controlled by other drugs...
October 6, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28981992/initial-experience-with-carboplatin-desensitization-a-case-series-in-a-paediatric-hospital
#18
LETTER
Pablo Rodríguez Del Río, Maitane Andión, David Ruano, Carmelo Escudero Diez, Paula Méndez Brea, Silvia Sánchez-García, María Dolores Ibáñez
For several years, carboplatin has been the most efficacious and safest first-line treatment for paediatric low-grade gliomas (LGGs), although very recently vinblastine has been proven to display a better safety profile with similar efficacy (1). Classically, hypersensitivity reactions to carboplatin appeared in around 27% to 42% of cases (2). These reactions are especially frequent as of the seventh cycle (3) in adults and the ninth in children (4), leading to treatment withdrawal and the use of second-line drugs...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28981985/early-life-sensitization-to-hen-s-egg-predicts-asthma-and-rhinoconjunctivitis-at-14-years-of-age
#19
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Sensitization to both inhalant and food allergens has been shown to be risk factors for development of asthma and rhinoconjunctivitis (RC). However, few studies have addressed the role of transient or persistent IgE sensitization to specific allergens in early life for later development of allergic diseases. The aim of this study was to explore the association between transient and persistent sensitization in early-life and the development of asthma and RC at 6 and 14 years...
October 5, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28981982/late-presenting-atypical-severe-combined-immunodeficiency-scid-associated-with-a-novel-missense-mutation-in-dclre1c
#20
LETTER
Mikael Sundin, Mikael Uhlin, Ahmed Gaballa, Kim Ramme, Per Marits, Jakob Nilsson
Immunodeficiency associated with mutations in the DNA cross-link repair 1C gene (DCLRE1C) can have variable clinical presentations including severe combined immunodeficiency (SCID), Omenn syndrome, atypical SCID or common variable immunodeficiency (CVID) (1-3). DCLRE1C encodes the protein Artemis, a nuclease with intrinsic 5'-3' exonuclease activity on single-stranded DNA that is involved in non-homologous end joining (NHEJ). Artemis is essential for V(D)J recombination of the immunoglobulin and T-cell receptor genes that occur during B- and T-cell development...
October 5, 2017: Pediatric Allergy and Immunology
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