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Pediatric Allergy and Immunology

Jovanka King, Stephan Borte, Nicholas Brodszki, Ulrika von Döbeln, C I Edvard Smith, Lennart Hammarströma
KREC (kappa-deleting recombining excision circles) quantification has been used in newborn screening programs to identify infants with X-linked agammaglobulinemia (XLA) and other B cell associated forms of primary immunodeficiency disease (PID). We evaluated KREC quantification in patients with XLA at various time points throughout life in order to determine the utility of this assay beyond the newborn period. We found that levels remain consistently low or absent throughout life, thus demonstrating that KREC quantification enables identification of patients with XLA and is a useful diagnostic tool in the newborn period, childhood and adulthood...
March 15, 2018: Pediatric Allergy and Immunology
F Schocker, A Recke, S Kull, M Worm, J Behrends, U Jappe
The commentary of Chirumbolo et al.1 on our recently published article needs to be addressed in some issues that if not adjusted in this reply may lead to misunderstandings. The concerns give us the opportunity to provide the reader with more details on the clinical data of our patient and with deeper insights into our test performances that might have been too restricted in our original case presentation.In their comment Chirumbolo et al. This article is protected by copyright. All rights reserved.
March 14, 2018: Pediatric Allergy and Immunology
Anaïs Pipet, Cécile Rochefort-Morel, Martine Drouet, Brigitte Nicolie, Claire Bernier, Cyrille Hoarau, Clothilde Marty, Antoine Magnan
We react to your very well-described and documented case of fixed-drug eruption (FDE) to ceftazidime. You assess that "this is the first case of FDE to ceftazidime in a child with cystic fibrosis". This is not completely right. This article is protected by copyright. All rights reserved.
March 14, 2018: Pediatric Allergy and Immunology
Philippe A Eigenmann
Skin diseases related to allergy are common in childhood and pediatric allergists are commonly faced with atopic eczema, treatment schemes for which include calcineurin inhibitors: commonly used topical drugs which control inflammatory skin flares. In the first review of this issue, Nakahira et al provide mechanistic insights, among others, into modulation of the immune response by tacrolimus (1). Prevention of atopic eczema is addressed by Wickens et al. This article is protected by copyright. All rights reserved...
March 13, 2018: Pediatric Allergy and Immunology
Angela Deyà-Martínez, Ana Esteve-Solé, Natalia Vélez-Tirado, Veronica Celis, Jordi Costa, Maria Cols, Cristina Jou, Alexandru Vlagea, Ana María Plaza-Martin, Manel Juan, Laia Alsina
BACKGROUND: One of the most frequent non-infectious complications of humoral immunodeficiencies with a CVID-like pattern is a particular form of inflammatory lung disease which is called granulomatous-lymphocytic interstitial lung disease (GLILD). Its development worsens patient prognosis, with a significant decrease in survival. Currently there are no unified guidelines regarding its management, and different combinations of immunosuppressants have been used with variable success. METHODS: Clinical and radiological data were collected from patient's medical charts...
March 12, 2018: Pediatric Allergy and Immunology
Xiaodong Jiang, Chun Shen, Yuan Dai, Fan Jiang, Shenghui Li, Xiaoming Shen, Yan Hu, Fei Li
BACKGROUND: The relationship between food allergy and respiratory allergy, and attention-deficit/hyperactivity disorder (ADHD) in children is rarely investigated. Our objective is to determine whether early food allergy and respiratory allergy symptoms are associated with the prevalence of ADHD in Chinese school-age children. METHODS: This cross-sectional study was conducted in school-age children using cluster-stratified methods from nine cities across China between November and December 2005...
March 9, 2018: Pediatric Allergy and Immunology
Maria Michelle Papamichael, Som Kumar Shrestha, Catherine Itsiopoulos, Bircan Erbas
BACKGROUND: The evidence is mixed on the use of long chain omega 3 fatty acids in the prevention and management of childhood asthma. METHODS: We conducted a systematic search and meta-analysis investigating the role of fish intake, the main dietary source of long chain omega-3 fatty acids, on asthma in children. RESULTS: A total of 1,119 publications were identified. Twenty-three studies on fish intake in association with childhood asthma were included in the final review...
March 9, 2018: Pediatric Allergy and Immunology
Takeshi Matsubara, Hiroshi Iwamoto, Yuki Nakazato, Tomoyuki Okamoto, Tatsuya Ehara, Hirohisa Izumi, Yasuhiro Takeda
BACKGROUND: Epicutaneous sensitization to food allergens can occur through defective skin barriers. However, the relationship between oral tolerance and epicutaneous sensitization remains to be elucidated. We aimed to determine whether prior oral exposure to whey proteins or their hydrolysates prevents epicutaneous sensitization and subsequent food allergic reaction to the whey protein, β-lactoglobulin (β-LG), and investigated the underlying mechanisms. METHODS: BALB/c mice were given whey protein concentrate (WPC), two kinds of partial whey protein hydrolysate (PWH1 or PWH2), or extensive whey protein hydrolysate (EWH) in drinking water for 21 days...
March 8, 2018: Pediatric Allergy and Immunology
Andrew MacGinnitie, Radhika Kamalia, Luis Alvernaz, Karol Timmons, Victoria Hamel, Alexander Lafreniere, Brian Minsk, Craig Platt, Pui Lee, Elizabeth Burke-Roberts, Meredith Dilley
Food challenges are critical to determine if an individual has food allergy when history and testing are inconclusive or the allergy may have been outgrown.(1) Passing a challenge may have nutritional, psychological and financial benefits.(1-3) We and others have shown that challenges can be safely carried out in a clinic setting.(4-9) This article is protected by copyright. All rights reserved.
March 7, 2018: Pediatric Allergy and Immunology
Kohei Hasegawa, Christopher J Stewart, Juan C Celedón, Jonathan M Mansbach, Courtney Tierney, Carlos A Camargo
Bronchiolitis is the most common lower respiratory infection in infants, and the leading cause of infant hospitalizations in the U.S. (approximately 130,000 hospitalizations annually). Prior research has linked vitamin D status to bronchiolitis pathobiology. Indeed, 25-hydroxyvitamin D (25OHD) undergoes enzymatic conversions to its biologically-active form, 1,25-dihydroxyvitamin D (1,25OH2 D), in immune cells (e.g., macrophages, dendritic cells and T cells), and plays a pleiotropic regulatory role on both innate and adaptive immune systems...
March 7, 2018: Pediatric Allergy and Immunology
Paraskevi Xepapadaki, Claus Bachert, Susetta Finotto, Tuomas Jartti, George N Konstantinou, Alexander Kiefer, Marek Kowalski, Anna Lewandowska-Polak, Heikki Lukkarinen, Eirini Roumpedaki, Anna Sobanska, Ina Sintobin, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G Papadopoulos
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association to viral/microbial exposures and immunological responses. We present the cohort design, demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls...
March 7, 2018: Pediatric Allergy and Immunology
Keerthi Reddy, Mary Kearns, Santiago Alvarez-Arango, Ismael Carrillo-Martin, Nathaly Cuervo-Pardo, Lyda Cuervo-Pardo, Ves Dimov, David M Lang, Sonia Lopez-Alvarez, Brian Schroer, Kaushik Mohan, Mark Dula, Simin Zheng, Claudia Kozinetz, Alexei Gonzalez-Estrada
BACKGROUND: Food allergy affects an estimated 8% of children and 3% of adults in the US. Food-allergic individuals increasingly use the web for medical information. We sought to determine the educational quality of food allergy YouTube videos. METHODS: We performed a YouTube search using keywords "food allergy" and "food allergies". The 300 most viewed videos were included and analyzed for characteristics, source, and content. Source was further classified as health care provider, alternative medicine provider, patient, company, media, and professional society...
March 7, 2018: Pediatric Allergy and Immunology
Lennart Bråbäck, Caroline J Lodge, Adrian J Lowe, Shyamali C Dharmage, David Olsson, Bertil Forsberg
BACKGROUND: Some human and animal studies have recently shown that maternal grandmother's smoking during pregnancy increases the risk of asthma in the grandchildren. We have investigated whether sex of the exposed parent and/or grandchild modifies the association between grandmaternal smoking and grandchild asthma. METHODS: We formed a cohort study based on linkage of national registries with prospectively collected data over three generations. Smoking habits in early pregnancy were registered since 1982 and purchases of prescribed medication since 2005...
March 7, 2018: Pediatric Allergy and Immunology
Adiel Marom, Dan Miron, Baruch Wolach, Ronit Gavrieli, Menachem Rottem
Burkholderia gladioli is a rod-shaped gram-negative aerobic bacteria associated mostly with plant pathology, it's role as a human pathogen is rare. Infections due to B. Gladioli have been reported in individuals who were immune suppressed. We present the case of a 13-month-old child for whom a diagnosis of chronic granulomatous disease (CGD) was made following skin and lymph node infection with Burkholderia gladioli. This is one of the few reported cases in children and the second in which this bacterial infection was the sole manifestation of CGD...
March 6, 2018: Pediatric Allergy and Immunology
Silvia Carraro, Sara Bozzetto, Giuseppe Giordano, Dania El Mazloum, Matteo Stocchero, Paola Pirillo, Stefania Zanconato, Eugenio Baraldi
BACKGROUND: Many children of preschool age present with recurrent wheezing. Most of them outgrow their symptoms, while some have early-onset asthma. Aim of this prospective preliminary study was to apply a metabolomic approach to see whether biochemical-metabolic urinary profiles can have a role in the early identification of the children with asthma. METHODS: Preschool children with recurrent wheezing were recruited and followed up for 3 years, after which they were classified as cases of transient wheezing or early-onset asthma...
February 22, 2018: Pediatric Allergy and Immunology
Styliana Vasileiadou, Göran Wennergren, Frida Strömberg Celind, Nils Åberg, Rolf Pettersson, Bernt Alm, Emma Goksör
BACKGROUND: The prevalence of allergic rhinitis has increased, but the cause of this rise is partly unknown. Our aim was to analyse the prevalence, risk factors, and protective factors for allergic rhinitis in 12-year-old Swedish children. METHODS: Data were collected from a prospective, longitudinal cohort study of children born in western Sweden in 2003. The parents answered questionnaires when the children were 6 months to 12 years. The response rate at 12 years was 76% (3637/4777) of the questionnaires distributed...
February 15, 2018: Pediatric Allergy and Immunology
Rosa M Pacheco-González, Luis García-Marcos, Eva Morales
Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis was conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions. Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function...
February 14, 2018: Pediatric Allergy and Immunology
Amy Eapen, Kirsten M Kloepfer
Omalizumab has been approved for chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria (CSU) in children 12 years and older. Two treatment doses of omalizumab are available: 150 mg or 300 mg every 4 weeks. While 150 mg has been shown to be effective, most patients with CIU/CSU require 300 mg every 4 weeks to achieve symptom improvement.1,2. Although the cost of anti-IgE treatment can be high, there are reports of successful remission in CIU/CSU for difficult-to-treat cases, with 70.4% of patients treated with omalizumab reporting resolution of symptoms (versus 4...
February 14, 2018: Pediatric Allergy and Immunology
Simona Barni, Francesca Mori, Annamaria Bianchi, Neri Pucci, Elio Novembre
A 1-month-old male infant, only breastfed from birth, developed a localized edema of the hands and feet a few minutes after his first ingestion of a cow's milk (CM) formula. A complete allergy work-up showed positive skin prick test (SPT) to CM (7-mm wheal) and serum-specific IgE (s-IgE) (ImmunoCAP, Phadia, Uppsala, Sweden) to CM and CM proteins (s-IgE to CM 62.3 kUA/l, alpha-lactoalbumin 79.1 kUA/ml, beta-lactoglobulin 34.7 kUA/l, casein 98.7 kUA/l, total serum IgE 501 kU/l), allowing for a reliable diagnosis of IgE-mediated cow's milk allergy (CMA)...
February 14, 2018: Pediatric Allergy and Immunology
Jenni Lehtimäki, Tiina Laatikainen, Antti Karkman, Leena von Hertzen, Tari Haahtela, Ilkka Hanski, Lasse Ruokolainen
In western societies, the majority of children are nurtured in daycares. About 80% of 3-5 year-old children attend formal child care in OECD-countries [1]. As children spend daily a large proportion of their time in daycares, their practices can have an important contribution to the overall exposure of children to natural environments. This can be important, as allergic sensitization has been associated with limited connection with nature [2]. The link between natural environments and allergy is thought to be mediated via exposure to beneficial environmental microbes [3]...
February 8, 2018: Pediatric Allergy and Immunology
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