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Pediatric Allergy and Immunology

Hasti Hadizadeh, M Masoud Salehi, Shabnam Khoramnejad, Kia Vosoughi, Nima Rezaei
BACKGROUND: We aimed to establish the prevalence of parental consanguinity among patients with primary immunodeficiency diseases (PID), and compare the prevalence with the general population. METHOD: We searched PubMed, EMBASE, and Scopus for studies mentioning parental consanguinity prevalence in PID patients and calculated the prevalence odds ratio (POR) of parental consanguinity in each study, compared to a matched healthy population. RESULTS: We identified 21 eligible studies with a total population of 18091 accounting for sample overlap...
November 28, 2016: Pediatric Allergy and Immunology
Cristina Cifaldi, Giulia Angelino, Maria Chiriaco, Silvia Di Cesare, Alessia Claps, Jessica Serafinelli, Paolo Rossi, Antonio Antoccia, Gigliola Di Matteo, Caterina Cancrini, Jean Pierre De Villartay, Andrea Finocchi
The non-homologous end joining (NHEJ) pathway is involved in the repair of the DNA double-strand breaks. Defects in NHEJ factors result in IR sensitivity, and in defects in V(D)J recombination leading to immunodeficiency. DNA Ligase IV is an essential component that performs the final 'end processing' step of NHEJ. This article is protected by copyright. All rights reserved.
November 28, 2016: Pediatric Allergy and Immunology
Carina Venter, Kari R Brown, Kate Maslin, Debra J Palmer
As the prevalence of allergic disease dramatically rises worldwide, prevention strategies are increasingly being considered. Given the potential modulatory effect of nutritional factors on disease, altering maternal diet during pregnancy and/or lactation has been considered in preventing allergic disease in offspring. Though there are a number of observational studies that have examined possible associations between maternal diet and allergic outcomes in offspring, interventional trials are limited. Furthermore, there is a paucity of studies that have prospectively studied maternal dietary intake as well as measuring maternal and infant biological samples (blood, urine, breast milk) and their relation to allergic outcomes in infants...
November 19, 2016: Pediatric Allergy and Immunology
Carla Mastrorilli, Daniela Posa, Francesca Cipriani, Carlo Caffarelli
Novel approaches are currently offered for the diagnostic work-up and therapeutic management of allergic rhinitis and asthma. New predictive biomarkers of allergy and asthma are available. Primary and secondary prevention, earlier intervention, and modification of the natural history of allergic rhinitis and asthma are being intensively investigated. This review highlights advances in the understanding of the etiology, diagnosis, and management of atopic airway diseases in childhood, as well as prenatal and early-life risk factors and strategies for prevention...
November 10, 2016: Pediatric Allergy and Immunology
Franklin S Mariño-Sánchez, Meritxell Valls-Mateus, Karen Ruiz-Echevarría, Isam Alobid, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Lozano-Blasco, María T Giner-Muñoz, Jesús Rodríguez-Jorge, Oliver Haag, Ana M Plaza-Martin, Joaquim Mullol
BACKGROUND: Allergic rhinitis (AR) is the most common chronic disease among children. To characterize the disease, a modified classification of severity (m-ARIA) has recently been validated in AR children. When medical treatment fails, surgery for nasal obstructive disorders (NOD) may be a therapeutic option. Our objective was to assess the prevalence of NOD and their influence in medical treatment response among children with persistent AR (PER). METHODS: In a prospective, real-life study, 130 pediatric PER patients (13...
November 1, 2016: Pediatric Allergy and Immunology
J A M Emons, B M J Flokstra-de Blok, C de Jong, T van der Molen, H K Brand, N J T Arends, R Amaral, J A Fonseca, R Gerth van Wijk
BACKGROUND: Allergic rhinitis and asthma are common and closely related diseases. Recently, a Portugese questionnaire has been developed 'The Control of Allergic Rhinitis and Asthma Test' (CARATkids) that measures disease control of both diseases in children. This study aims to validate the CARATkids in Dutch children and for the first time in adolescents. In addition, to calculate the minimal clinically important difference (MCID). METHODS: A prospective observational study was conducted in an outpatient clinic...
November 1, 2016: Pediatric Allergy and Immunology
Stefanie Braig, Johannes M Weiss, Tobias Stalder, Clemens Kirschbaum, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Evidence linking maternal psychosocial stress during pregnancy to subsequent child atopic dermatitis (AD) is growing but the definition of AD is diverse and results are inconsistent. We aimed to analyze the relationship between stress and AD using alternative methods of measurement of stress and AD. METHODS: In the Ulm SPATZ Health Study, chronic stress and symptoms of anxiety and depression were assessed by standardized self-reported questionnaires in 934 mothers of singletons following delivery in Ulm, Germany, from 04/2012-05/2013...
November 1, 2016: Pediatric Allergy and Immunology
Grace Isobel Davies, Domenica Davies, Sarah Charles, Sara Laura Barnes, Donald Bowden
To our knowledge, this is the first case and protocol in the literature of paediatric desensitisation to deferasirox following the adverse skin reaction of erythema multiforme major. Thalassemia is one of the most common genetic conditions globally (1, 2). β thalassemia major results in severe anaemia requiring monthly, life-long red blood cell transfusions with life-long iron chelator therapy required to control ferritin levels (1, 3). This article is protected by copyright. All rights reserved.
October 31, 2016: Pediatric Allergy and Immunology
Valentina Gallo, F Nicole Dijk, John W Holloway, Susan M Ring, Gerard H Koppelman, Dirkje S Postma, David P Strachan, Raquel Granell, Johan C de Jongste, Vincent W V Jaddoe, Herman T den Dekker, Liesbeth Duijts, A John Henderson, Seif O Shaheen
BACKGROUND: Animal data have suggested that the transient receptor potential ankyrin-1 (TRPA1) ion channel plays a key role in promoting airway inflammation in asthma and may mediate effects of paracetamol on asthma, yet confirmatory human data are lacking. To study associations of TRPA1 gene variants with childhood asthma and total IgE concentration, and interactions between TRPA1 and prenatal paracetamol exposure on these outcomes. METHODS: We analysed associations between 31 TRPA1 single nucleotide polymorphisms (SNPs) and current doctor-diagnosed asthma and total IgE concentration at 7...
October 25, 2016: Pediatric Allergy and Immunology
Krista Lundelin, Tuija Poussa, Seppo Salminen, Erika Isolauri
BACKGROUND: Societies worldwide are faced with a progressive increase in immune-mediated health problems such as allergic, autoimmune and inflammatory diseases, as well as obesity. Perinatal administration of specific probiotic bacteria is an attractive approach in reducing the risk of these conditions, but long-term efficacy and safety data are lacking. The aim here was to evaluate the clinical benefit and long-term safety of specific probiotics administered during the perinatal period...
October 25, 2016: Pediatric Allergy and Immunology
Bodo Niggemann, Songül Yürek, Kirsten Beyer
The gold standard in the diagnostics of food allergy is oral food challenges (OFCs) - best performed in a double-blind, placebo-controlled manner (DBPCFC) [1]. Great efforts have been made to standardize oral food challenges [2]. As recommended, in our clinic oral food challenges are performed with semi-log dose increments every 30 minutes [3]. This article is protected by copyright. All rights reserved.
October 25, 2016: Pediatric Allergy and Immunology
Maxwell S Barnish, Nara Tagiyeva, Graham Devereux, Lorna Aucott, Steve Turner
BACKGROUND: Childhood asthma is a common condition whose prevalence is changing. We hypothesised that the relationship between asthma and associated risk factors has changed over a 50-year period. METHODS: An ecological study design was used. Children aged 8-13 attending schools in Aberdeen city were surveyed on seven occasions between 1964 and 2014. The following were determined: history of asthma, history of eczema, parental smoking, parental asthma, sex and socioeconomic status...
October 25, 2016: Pediatric Allergy and Immunology
Thomas Westergren, Sveinung Berntsen, Karin C Lødrup Carlsen, Petter Mowinckel, Geir Håland, Liv Fegran, Kai-Håkon Carlsen
BACKGROUND: Children with asthma may be less physically active than their healthy peers. We aimed to investigate whether perceived exercise limitation (EL) was associated with lung function or bronchial hyper-responsiveness (BHR), socioeconomic factors, prenatal smoking, overweight, allergic disease, asthma severity, or physical activity (PA). METHODS: The 302 children with asthma from the 10-year examination of the Environment and Childhood Asthma birth cohort study underwent a clinical examination including perceived EL (structured interview of child and parent(s)), measure of overweight (body mass index by sex and age passing through 25 kg/m(2) or above at 18 years), exercise-induced bronchoconstriction (forced expiratory volume in one-second (FEV1 ) pre- and post-exercise), methacholine bronchial challenge (severe BHR; provocative dose causing ≥20% decrease in FEV1 ≤ 1 μmol), and asthma severity score (dose of controller medication and exacerbations last 12 months)...
October 13, 2016: Pediatric Allergy and Immunology
Ilaria Baiardini, Salvatore Fasola, Laura Montalbano, Giovanna Cilluffo, Velia Malizia, Giuliana Ferrante, Fulvio Braido, Stefania La Grutta
No abstract text is available yet for this article.
October 12, 2016: Pediatric Allergy and Immunology
Mehtap Haktanir Abul, Selim Dereci, Sadan Hacisalihoglu, Fazil Orhan
BACKGROUND: Although kiwifruit is known as a common cause of food allergy, population-based studies concerning the prevalence of kiwifruit allergy do not exist. We aimed to determine the prevalence and clinical characteristics of IgE-mediated kiwifruit allergy in 6-18-year-old urban schoolchildren in a region where kiwifruit is widely cultivated. METHODS: This cross-sectional study recruited 20,800 of the randomly selected 6-18-year-old urban schoolchildren from the Rize city in the eastern Black Sea region of Turkey during 2013...
October 12, 2016: Pediatric Allergy and Immunology
Anna James, Katarina Stenberg Hammar, Lovisa Reinius, Jon R Konradsen, Sven-Erik Dahlén, Cilla Söderhäll, Gunilla Hedlin
BACKGROUND: The chitinase-like protein YKL-40 (CHI3L1) is elevated in the circulation of adults and schoolchildren with chronic severe asthma. It is unknown whether YKL-40 is altered in younger, preschool children with wheeze, acute or chronic. We therefore examined YKL-40 in preschool children during an acute episode of wheeze and during remission, in comparison with healthy controls. METHODS: Blood was obtained from 128 children (aged 6-44 months) at the emergency department during an acute episode of wheeze, and at two follow-up visits (approximately 3 months and 1 year later), as well as from 100 age-matched healthy controls on one occasion...
October 12, 2016: Pediatric Allergy and Immunology
Susanne Mueller-Rompa, Tobias Janke, Karin Schwaiger, Melanie Mayer, Johann Bauer, Jon Genuneit, Charlotte Braun-Fahrlaender, Elisabeth Horak, Andrzej Boznanski, Erika von Mutius, Markus Johannes Ege
BACKGROUND: Exposure to moulds has been related to asthma risk both positively and negatively, depending on the environmental setting. The pertinent results are based on generic markers or culturing methods though the majority of present fungi cannot be cultured under laboratory conditions. The aim of the present analysis was to assess environmental dust samples for asthma-protective fungal candidates with a comprehensive molecular technique covering also non-cultivable and non-viable fungi...
October 6, 2016: Pediatric Allergy and Immunology
Louis Jacob, Thomas Keil, Karel Kostev
BACKGROUND: Using routine healthcare data, the goal of this study was to examine the association between asthma and comorbid disorders in children in Germany. METHODS: Patients with a diagnosis of asthma documented by a German pediatrician in 2015 were identified. Demographic data included age and gender. Patients younger than 6 and older than 17 and individuals followed for less than a year before index date were excluded. Each patient was matched for age, sex, and physician with an asthma-free control...
October 5, 2016: Pediatric Allergy and Immunology
Giampaolo Ricci, Francesca Cipriani
In the last decades, international guidelines proposed different strategies of complementary foods introduction during weaning to prevent allergy. Avoidance measures, such as late introduction of allergenic foods, failed to show a significant preventive effect towards allergy. Recently, prospective randomized controlled studies suggested that the early introduction of solid foods - rather than the late introduction - could be a strategy to prevent allergic sensitization and food allergy. However, at today clear evidence of effectiveness and safety of early introduction are not yet available to recommend a radical change in the current clinical practice...
October 5, 2016: Pediatric Allergy and Immunology
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Atopic diseases are among the most common chronic diseases in adolescents, and it is uncertain whether the prevalence of atopic diseases has reached a plateau or is still increasing. The use of the ISAAC (International Study of Asthma and Allergy in Childhood) questionnaire has provided comparable prevalence rates from many countries, whereas studies including clinical examinations and strict diagnostic criteria are scarce. We aimed to investigate the prevalence of atopic diseases, the pattern of sensitization, and comorbidities at 14 years in a prospective birth cohort...
October 5, 2016: Pediatric Allergy and Immunology
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