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Pediatric Allergy and Immunology

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https://www.readbyqxmd.com/read/29314343/does-asthma-affect-school-performance-in-adolescents-results-from-the-swedish-population-based-birth-cohort-bamse
#1
Sara Nilsson, Maria Ödling, Niklas Andersson, Anna Bergström, Inger Kull
BACKGROUND: Asthma is common among schoolchildren and may influence quality of life and school attendance. However, it is unclear if asthma affects school performance. The aim of this study was to examine if different phenotypes of asthma affect school performance during adolescence. METHODS: The study population consisted of 1,715 adolescents from a population-based birth cohort, followed to age 16 with questionnaires and clinical examinations. Asthma was defined as at least 4 wheeze episodes or at least 1 wheeze episode in combination with inhaled steroids in the last 12 months...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314338/reduced-cdhr3-expression-in-children-wheezing-with-rhinovirus
#2
Katarina Stenberg Hammar, Katarzyna Niespodziana, Marianne van Hage, Juha Kere, Rudolf Valenta, Gunilla Hedlin, Cilla Söderhäll
BACKGROUND: Rhinovirus induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin related family member 3 (CDHR3) was identified as the RV-C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV-C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and mRNA expression of CDHR3 in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age-matched healthy children...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#3
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk for atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of one year. 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-)...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314322/association-between-pro-inflammatory-alleles-and-allergic-phenotypes-in-xhosa-adolescents
#4
Craig Laurence, Lize van der Merwe, Guicheng Zhang, Peter LeSouëf, Michael Levin
BACKGROUND: Significant differences exist in the prevalence, spectrum and severity of allergic diseases between developing and developed countries and between sub-populations within single countries. These discrepancies likely result from a complex interaction between genetic and environmental factors. However, the precise nature of the contribution of ethnicity to genetic differences in the predisposition to allergic disease is not yet fully understood. In particular, there is a paucity of literature regarding the genetic determinants of allergic disease in people of black African origin with little or no genetic admixture...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314287/association-of-between-obstructive-sleep-apnea-and-atopic-dermatitis-in-children-a-nationwide-population-based-cohort-study
#5
Je-Ming Hu, Chin-Sheng Lin, Sy-Jou Chen, Chao-Yang Chen, Cheng-Li Lin, Chia-Hung Kao
BACKGROUND: Atopic dermatitis (AD) is associated with systemic inflammation and may have a similar pathogenesis as obstructive sleep apnea (OSA). However, to date, studies on the association between AD and OSA is limited. OBJECTIVES: This study evaluated the association between OSA and AD in children in a large-scale, population-based cohort. METHODS: A total of approximately 120,736 children (<18 years) with newly diagnosed AD and 120,736 age- and sex-matched patients without AD from 2000 to 2007 were identified from Taiwan's National Health Insurance Research Database from 2000 to 2007...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314279/cow-s-milk-allergic-children-can-component-resolved-diagnostics-predict-duration-and-severity
#6
Thomas Houmann Petersen, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen, Esben Eller
BACKGROUND: Cow's Milk Allergy (CMA) affects 2% of all children. This study investigates CRD to cow's milk proteins in children suspected for CMA, by correlating the level of CRD with outcome of the oral challenge. Furthermore, we evaluate the ability of serial CRD measurements to distinguish children with persistent CMA from children developing tolerance. METHODS: We included data from 78 children referred to the Allergy Centre during a 13 years period. Results from oral food challenges including threshold, severity and sensitization data (IgE antibodies to whole milk protein, IgE components towards milk and skin prick test (SPT)) were collected...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314278/increased-sensitization-to-several-allergens-over-a-12-year-period-in-brazilian-children
#7
LETTER
Carolina Sanchez Aranda, Renata Rodrigues Cocco, Felipe F Pierotti, Marcia Mallozi, Jackeline Motta Franco, Arnaldo Carlos Porto, Ekaterini Goudouris, Lilian Moraes, Nelson A Rosário, Neusa Falbo Wandalsen, Antonio Carlos Pastorino, Emanuel Sarinho, Flavio Sano, Maria Leticia Chavarria, Magnus P Borres, Dirceu Solé
The prevalence of allergic sensitization and diseases, especially in the last decades, appears to have increased worldwide (1,2) . Change of habits and climate has been discussed as major contributing factors (1,3) . The first Brazilian Allergy Project (PROAL I) study was carried out in 2004 with the objective of documenting the sensitization rates to the major allergens in Brazilian allergic children (4) . This article is protected by copyright. All rights reserved.
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314275/an-approach-to-the-asthma-protective-farm-effect-by-geocoding-good-farms-and-better-farms
#8
Susanne E K Müller-Rompa, Iana Markevych, Alexander J Hose, Georg Loss, Inge M Wouters, Jon Genuneit, Charlotte Braun-Fahrländer, Elisabeth Horak, Andrzej Boznanski, Dick Heederik, Erika von Mutius, Joachim Heinrich, Markus J Ege
BACKGROUND: The highly consistent association of growing up on a farm with a reduced asthma risk has so far been attributed to direct farm exposure. In contrast, geographical determinants of the larger environment have never been assessed. In this study, the effects of proximity to farms and environmental variables in relation to the residential address on asthma and atopy were assessed. METHODS: Addresses of 2,265 children of the Bavarian arm of the GABRIELA-study were converted into geocodes...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29314270/association-of-leptin-with-disease-severity-and-inflammation-indicators-in-chinese-obese-children-with-allergic-rhinitis
#9
Wenlong Liu, Qingxiang Zeng, Lifeng Zhou, Renzhong Luo, Haipeng Dong
BACKGROUND: The prevalence of both obesity and allergic diseases in children has increased over the last several decades. However, the direct relationship between diverse allergic diseases and obesity has varied in different studies. Therefore, we aimed to examine the effect of obesity on the incidence and severity of allergic rhinitis (AR) and the possible key inflammation mediators during AR. METHODS: A total of 3,126 healthy students (without chronic diseases) were recruited from 14 randomly selected secondary schools in Guangzhou, China...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29266497/hepatitis-b-immunogenicity-after-a-primary-vaccination-course-associated-with-childhood-asthma-allergic-rhinitis-and-allergen-sensitization
#10
LETTER
Dong Keon Yon, Eun Kyo Ha, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han
There have been significant advances in our understanding of the immunology of allergic diseases in recent years. Most recent studies emphasize the importance of downregulation of Th1 and Th2 responses by regulatory T cells (Tregs), which is mediated by anti-inflammatory cytokines such as IL-10, rather than an imbalance of Th1 and Th2 responses.(1, 2) Many immuno-epidemiological studies on the relationships of allergic diseases with infections or vaccines have focused on the immunological backgrounds of the study subjects...
December 21, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29247543/side-effects-during-subcutaneous-immunotherapy-scit-in-children-with-allergic-diseases
#11
Max Alfons Tophof, Anne Hermanns, Thomas Adelt, Peter Eberle, Christine Gronke, Frank Friedrichs, Roland Knecht, Ernst Mönter, Helmut Schöpfer, Nicolaus Schwerk, Jörg Steinbach, Hans-Ulrich Umpfenbach, Christian Weißhaar, Brigitte Wilmsmeyer, Albrecht Bufe
BACKGROUND: Allergen-specific immunotherapy (AIT) is the only causal form of therapy for IgE-mediated allergic diseases. Subcutaneous immunotherapy (SCIT) is considered safe and well tolerated in adults, yet there is less evidence of safety in the pediatric population. METHODS: A noninterventional prospective observing longitudinal study was carried out to determine the incidence of local and systemic side effects by SCIT, routinely performed in pediatric patients...
December 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29240264/longitudinal-vitamin-d-deficiency-is-inversely-related-to-mite-sensitization-in-early-childhood
#12
Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang
BACKGROUND: There are few studies addressing the longitudinal analysis of vitamin D deficiency and its impact to the development of atopic diseases in early childhood. METHODS: We investigated 155 children who regularly followed up at our clinic for 5 years as subjects enrolled in a birth cohort study. The pattern of vitamin D levels from birth to 5 years of age was clustered using K-means method in R software. Absolute eosinophil count (AEC), total serum and specific immunoglobulin E antibodies against food (egg white, milk, and wheat) and inhalant allergens (D...
December 14, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29240247/do-we-still-need-oral-food-challenges-for-the-diagnosis-of-food-allergy
#13
REVIEW
Philippe A Eigenmann
Food challenges are standard in the diagnosis in patients suspected of being allergic to food. However, their role is regularly questioned due to the time required to perform them, and to their cost and the inherent risk of severe reactions. Food challenges have been challenged by recent advances defining threshold values for food-specific IgE helping to predict the probability of having symptoms to the suspected food. Also, identification of major allergens to various highly allergenic foods such as peanuts or tree nuts have contributed to an increased accuracy of IgE testing...
December 14, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29205511/mechanistic-insights-on-topical-tacrolimus-for-the-treatment-of-atopic-dermatitis
#14
REVIEW
Takeshi Nakahara, Hiroshi Morimoto, Naofumi Murakami, Masutaka Furue
More than fifteen years have passed since the clinical launch of topical tacrolimus for the treatment of atopic dermatitis. Its efficacy and safety have been clearly demonstrated in many global and domestic short-term and long-term clinical trials. Although the prolonged external application of steroids causes many adverse reactions including cutaneous atrophy, no such reactions occur with the use of topical tacrolimus. Therefore, the therapeutic guidelines recommend a combined topical treatment with tacrolimus and steroids...
December 4, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29197130/persistent-cow-s-milk-anaphylaxis-from-early-childhood-monitored-by-ige-and-bat-to-cow-s-and-human-milk-under-therapy
#15
LETTER
F Schocker, A Recke, S Kull, M Worm, U Jappe
Cow's milk allergy affects approximately 2 to 3% of children under 3 years. Allergic reactions often occur at an early onset within the first months of age [1]. In 80 to 85% of the described cases a natural tolerance develops until the age of 5 years. However, a proportion of 1% of adults remain cow's milk allergic, often associated with severe reactions [2]. Some breast-fed babies with cow's milk allergy still show symptoms despite a strict cow's milk-free diet of the nursing mother, and they react until the mother discontinues breast feeding...
December 2, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29197126/anaphylactic-reaction-to-galactose-derived-oligosaccharides-residues-from-lactose-used-as-a-drug-excipient
#16
LETTER
Ana Laura Mendes Becker Andrade, Adriana Gut Lopes Riccetto, Maria Marluce Dos Santos Vilela, Diogo Noin de Oliveira, Rodrigo Ramos Catharino, Marcos Tadeu Nolasco da Silva
Inhaled steroids are currently the most widely used and recommended medicines for the management of persistent asthma because of their high local and anti-inflammatory efficacy.1 There are three main presentations of the drug: aerosol spray (hydrofluoroalkane - HFA - as a propellant), liquid solution and dry powder inhaler. Dry powder devices are often preferred over HFA sprays in patients over 6 years of age, both for environmental issues and for the intrinsic advantages of the technique, such as ease of use and greater uptake and metabolism of the drug...
December 2, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29197125/proposal-for-management-of-the-infant-with-suspected-food-protein-induced-allergic-proctocolitis
#17
LETTER
Stefano Miceli Sopo, Serena Monaco, Giulia Bersani, Alberto Romano, Claudia Fantacci
A 13-month-old girl was referred to our allergologic ambulatory because of she presented haematochezia mixed with mucus in the stool when she was two months old; an endoscopy showed eosinophilic infiltrates in the rectal mucosa with lymphoid nodular hyperplasia. At the age of three months, a food protein-induced allergic proctocolitis (FPIAP) diagnosis was established. Her mother started a cow's milk (CM) free diet and then, due to the persistence of haematochezia after a month from the beginning of the elimination diet, also an egg- and beef-free diet...
December 2, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29197124/breast-milk-cells-trafficking-induces-microchimerism-mediated-immune-system-maturation-in-the-infant
#18
REVIEW
Jean-Pierre Molès, Edouard Tuaillon, Chipepo Kankasa, Anne-Sophie Bedin, Nicolas Nagot, Arnaud Marchant, Joann M McDermid, Philippe Van de Perre
Initiating breastfeeding within the first hour of life confers an important benefit in terms of child mortality and severe morbidity. Intestinal permeability to ingested macromolecules and immunoglobulins is limited to the first days of human life. These exchanges cease in the very early post-partum period but may increase beyond the neonatal period in response to local inflammation or introduction of a weaning food. From animal- and limited human-based observations, compelling evidence points out to breast milk cells also trafficking from mother to infant mucosal tissues and participating to the maternal microchimerism...
December 2, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168294/association-of-prenatal-folate-status-with-early-childhood-wheeze-and-atopic-dermatitis
#19
Aditi Roy, Mehmet Kocak, Terryl J Hartman, Shanda Vereen, Margaret Adgent, Chandrika Piyathilake, Frances A Tylavsky, Kecia N Carroll
BACKGROUND: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S.to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a U.S. cohort. METHODS: We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2(nd) and 3(rd) trimester maternal plasma...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168282/risk-factors-for-asthma-occurrence-in-children-with-early-onset-atopic-dermatitis-an-8-year-follow-up-study
#20
Ching-Chun Huang, Tung-Liang Chiang, Pau-Chung Chen, Shio-Jean Lin, Hui-Ju Wen, Yue-Liang Guo
BACKGROUND: Children with early-onset atopic dermatitis (AD) are at substantial risk of developing asthma later in life, and identifying the critical window of detrimental exposure is advantageous for implementing preventive actions. The aim of this study was to evaluate the role of exposure to environmental modifiers during pregnancy and early childhood in asthma occurrence in an infantile AD cohort. METHODS: Eligible study participants were selected from the Taiwan Birth Cohort Study, which enrolled 24200 newborns in 2005...
November 23, 2017: Pediatric Allergy and Immunology
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