Read by QxMD icon Read

Pathogens and Global Health

Sandra Bos, Gilles Gadea, Philippe Despres
Dengue disease is the most prevalent mosquito-borne viral infection in humans. At least one half of the global population is estimated at risk of infection and an estimated 390 million people are infected each year. Over the past few years, dengue burden continued to increase, mainly impacting developing countries. Alarming changes in dengue epidemiology were observed highlighting a spread from tropical to subtropical regions as well as urban to rural areas. An increase in the co-infections with the four serotypes has also been noticed, involving a shift in the targeted population from pediatric to adult...
September 14, 2018: Pathogens and Global Health
Kaustubh Bora, Dulmoni Das, Bhupen Barman, Probodh Borah
BACKGROUND: Internet-videos, though popular sources of public health information, are often unverified and anecdotal. We critically evaluated YouTube videos about Zika virus available during the recent Zika pandemic. METHODS: Hundred-and-one videos were retrieved from YouTube (search term: zika virus). Based upon content, they were classified as: informative, misleading or personal experience videos. Quality and reliability of these videos were evaluated using standardized tools...
August 29, 2018: Pathogens and Global Health
Mohammad Sadeghi, Roya Ahmadrajabi, Tania Dehesh, Fereshteh Saffari
Neisseria meningitidis is an important causative agent of bacterial meningitis. The nasopharynx is the only known reservoir of this organism. Although the relationship between carriage and invasive disease is not completely understood, asymptomatic meningococcal carriers are considered as the most important sources for causing strains of disease. Living in closed and overcrowded places such as university dormitories can increase the carriage rate and meningococcal disease. This cross-sectional study was conducted to determine the prevalence of N...
August 29, 2018: Pathogens and Global Health
Jennifer S F da Silva, Cynthia Braga, Felipe M Duarte, Paula Oliveira, Carlos Feitosa Luna, Márcia Marcondes, Josué Araújo, Maria Rosangela Grilis, Paula Fernanda A de Souza Melo, Eduardo Brandão, Abraham Rocha
The Global Program to Eliminate Lymphatic Filariasis has achieved extraordinary success in reducing transmission and preventing morbidity through mass drug administration (MDA) to the population at-risk. Brazil is the only currently using diethylcarbamazine citrate (DEC) alone for MDA, so an assessment of its effectiveness is needed. We report the trends of filarial markers in a cohort of 175 individuals infected with Wuchereria bancrofti in areas that underwent MDA in the city of Olinda, Northeastern Brazil...
August 15, 2018: Pathogens and Global Health
Stefano Di Bella, Niccolò Riccardi, Daniele Roberto Giacobbe, Roberto Luzzati
Schistosomiasis is a parasitic infection that has evolved together with the humankind. Evidence in ancient Egyptian medical papyri or Assyrian medical texts reported signs and symptoms that could resemble schistosomiasis; similarly, some biblical passages describe an epidemic (depicted as a 'curse') that has been hypothesized to be associated with schistosomiasis' spread in Mesopotamia. In the modern era, Theodor Maximilian Bilharz and Patrick Manson (the 'father of tropical medicine') gave an impetus to the knowledge about the parasite and its spread until the present time, when immunoassays and molecular biology on mummies allowed retracing important milestones regarding schistosomiasis' evolution...
July 17, 2018: Pathogens and Global Health
Sebastián Napp, Dusan Petrić, Núria Busquets
Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with the combination of introduction of different WNV strains from lineages 1 and 2, and the establishment of endemic cycles. We found a positive correlation between the risk of WNV re-emergence in an area and the number of human cases reported in the previous year...
July 6, 2018: Pathogens and Global Health
Marta Serrano-Moliner, María Morales-Suarez-Varela, M Adela Valero
BACKGROUND: Foodborne nematodiasis are caused by the ingestion of food contaminated by helminths. In Europe, these diseases are present in all countries. OBJECTIVES: To review the available data on epidemiology and management of foodborne nematodiasis in the European Union, detect any trends and determine the possible causes of the observed changes. METHODS: A review of available literature published between 2000 and 2016 was conducted. RESULTS: Out of 1523 cases described in the literature, 1493 cases were autochthonous and 30 cases were imported...
June 29, 2018: Pathogens and Global Health
Saujanya Vruddhula
No abstract text is available yet for this article.
June 2018: Pathogens and Global Health
Vanina Varni, Yosena Chiani, Ariel Nagel, Paula Ruybal, Norma Bibiana Vanasco, Karina Caimi
Leptospirosis is a globally distributed zoonosis. Epidemiological data are scarce and present major challenge because of the varied clinical presentations. Multilocus Sequence Typing has already proven to be a robust molecular typing method providing accurate results for strain characterization. We have adapted our MLST scheme by reducing the set of loci to facilitate Leptospira typing directly from human clinical samples. The application of this 3-locus scheme provides Leptospira species and allelic profiles of the samples retaining the power of discrimination of the whole scheme...
June 2018: Pathogens and Global Health
Larisa Rudenko, Megan J Palmer, Kenneth Oye
Governance is a broader and more flexible concept than statute-driven regulations as it incorporates components outside the latter's remit. Considerations of governance are critical in the development of emerging biotechnologies such as gene drive organisms. These have been proposed or are being developed to address public and environmental health issues not addressed easily by conventional means. Here, we consider how the concept of governance differs from statute-driven regulation with reference to the role each may play in the development of gene drive organisms...
June 2018: Pathogens and Global Health
Matthew R Just, Stephen W Carden, Sheng Li, Kelly K Baker, Manoj Gambhir, Isaac Chun-Hai Fung
Epidemiological studies have identified an increased risk of diarrheal diseases associated with using shared sanitation facilities. We hypothesized that this might be related to differences in transmission routes of pathogens. We proposed a mathematical model of two fictitious pathogens, one transmitted with an environmental reservoir and one without. We assumed that individuals susceptible to one pathogen are not susceptible to the other, and therefore, decoupled the two models. We initialized the model with 99% individuals being susceptible...
June 2018: Pathogens and Global Health
Raíza Nara Cunha Moizéis, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Marcos da Matta Guedes, Hannaly Wana Bezerra Pereira, Daniel Carlos Ferreira Lanza, Judson Welber Veríssimo de Azevedo, Josélio Maria de Araújo Galvão, José Veríssimo Fernandes
Chikungunya fever is an emerging arbovirus infection, representing a serious public health problem. Its etiological agent is the Chikungunya virus (CHIKV). Transmission of this virus is mainly vector by mosquitoes of the genus Aedes, although transmission by blood transfusions and vertical transmission has also been reported. The disease presents high morbidity caused mainly by the arthralgia and arthritis generated. Cardiovascular and neurological manifestations have also been reported. The severity of the infection seems to be directly associated with the action of the virus, but also with the decompensation of preexisting comorbidities...
June 2018: Pathogens and Global Health
Navaneethan Palanisamy, Dario Akaberi, Johan Lennerstrand, Åke Lundkvist
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis virus (TBEV). Currently, very little is known about the pathologies of AHFV. In this study, using the available genome information of AHFV, KFDV and TBEV, we have predicted and compared the following aspects of these viruses: evolution, nucleotide and protein compositions, recombination, codon frequency, substitution rate, N- and O-glycosylation sites, signal peptide and cleavage site, transmembrane region, secondary structure of 5' and 3' UTRs and RNA-RNA interactions...
June 2018: Pathogens and Global Health
E K Oladipo, E H Awoyelu, J K Oloke
No abstract text is available yet for this article.
June 2018: Pathogens and Global Health
Fateh Karimian, Hassan Vatandoost, Yavar Rassi, Naseh Maleki-Ravasan, Nayyereh Choubdar, Mona Koosha, Kourosh Arzamani, Eslam Moradi-Asl, Arshad Veysi, Hamzeh Alipour, Manouchehr Shirani, Mohammad Ali Oshaghi
Sand flies of Phlebotomus papatasi and P. sergenti are the main vectors of cutaneous leishmanisis (CL) in the old world. We aimed to screen Iranian P. papatasi and P. sergenti for their natural infections with Wolbachia and to determine their phylogenetic association with other species. Wolbachia surface protein (wsp) gene was PCR amplified from DNA extracted from Phlebotomus species, sequenced, and were analysed in combination with wsp sequences related to Phelebtominae and other insects. All Wolbachia-infecting Iranian sand flies of P...
May 2018: Pathogens and Global Health
Silvia Ciocchetta, Natalie A Prow, Jonathan M Darbro, Francesca D Frentiu, Sandro Savino, Fabrizio Montarsi, Gioia Capelli, John G Aaskov, Gregor J Devine
Arthropod-borne disease outbreaks, facilitated by the introduction of exotic mosquitoes, pose a significant public health threat. Recent chikungunya virus (CHIKV) epidemics in Europe highlight the importance of understanding the vector potential of invading mosquitoes. In this paper we explore the potential of Aedes koreicus, a mosquito new to Europe, to transmit CHIKV. Mosquitoes were challenged with CHIKV and maintained at two temperatures: 23 °C and a fluctuating temperature. Total CHIKV infection rates at 3, 10 and 14 days post-feeding were low for both temperature treatments (13...
May 2018: Pathogens and Global Health
Anastasia I Lev, Eugeny I Astashkin, Angelina A Kislichkina, Ekaterina V Solovieva, Tatiana I Kombarova, Olga V Korobova, Olga N Ershova, Irina A Alexandrova, Vladimir E Malikov, Alexander G Bogun, Alexander I Borzilov, Nikolay V Volozhantsev, Edward A Svetoch, Nadezhda K Fursova
The antibacterial resistance and virulence genotypes and phenotypes of 148 non-duplicate Klebsiella pneumoniae strains collected from 112 patients in Moscow hospitals in 2012-2016 including isolates from the respiratory system (57%), urine (30%), wounds (5%), cerebrospinal fluid (4%), blood (3%), and rectal swab (1%) were determined. The majority (98%) were multidrug resistant (MDR) strains carrying blaSHV (91%), blaCTX-M (74%), blaTEM (51%), blaOXA (38%), and blaNDM (1%) beta-lactamase genes, class 1 integrons (38%), and the porin protein gene ompK36 (96%)...
May 2018: Pathogens and Global Health
Maryam Ramezany, Iraj Sharifi, Zahra Babaei, Pooya Ghasemi Nejad Almani, Amireh Heshmatkhah, Alireza Keyhani, Mohammad Reza Aflatoonian, Mohammad Ali Mohammadi, Fatemeh Sharifi, Mehdi Bamorovat
This study aimed to explore geographic distribution and molecular characterization of cutaneous leishmaniasis (CL) species by amplifying two popular markers in kinetoplast DNA and internal transcribed spacer 1 loci by nested-PCR, and characterized by sequencing and phylogenetic analyses. Findings demonstrated that two species co-existed in the province: L. tropica (88.5%) and L. major (11.5%). All gender and age groups were equally infected, although males, 21-30 years old, exhibited a significantly higher infection...
May 2018: Pathogens and Global Health
Ada Kazi, Candy Chuah, Abu Bakar Abdul Majeed, Chiuan Herng Leow, Boon Huat Lim, Chiuan Yee Leow
Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes...
May 2018: Pathogens and Global Health
Usha Yadav, Mohd Ashraf Khan
The GPI (Glycosylphosphatidylinositol) biosynthetic pathway is a multistep conserved pathway in eukaryotes that culminates in the generation of GPI glycolipid which in turn anchors many proteins (GPI-APs) to the cell surface. In spite of the overall conservation of the pathway, there still exist subtle differences in the GPI pathway of mammals and other eukaryotes which holds a great promise so far as the development of drugs/inhibitors against specific targets in the GPI pathway of pathogens is concerned. Many of the GPI structures and their anchored proteins in pathogenic protozoans and fungi act as pathogenicity factors...
May 2018: Pathogens and Global Health
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"