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Osteoarthritis and Cartilage

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https://www.readbyqxmd.com/read/28089900/the-rs4238326-polymorphism-in-aldh1a2-gene-potentially-associated-with-non-post-traumatic-knee-osteoarthritis-susceptibility-a-two-stage-population-based-study
#1
Minjie Chu, Xiaoyue Zhu, Chunli Wang, Jiesheng Rong, Yidan Wang, Shengyu Wang, Baifen Xing, Yuchun Tao, Xun Zhuang, Liying Jiang
OBJECTIVE: A recent genome-wide association study reported significant associations of genetic variants within the ALDH1A2 gene with osteoarthritis (OA) of the hand in European populations. However, these findings have not been well generalized to other joints, or to other populations. METHODS: We performed a two-stage population-based case-control study including 196 non-post traumatic knee OA cases and 442 controls in the first stage and independent 143 non-post traumatic knee OA cases and 238 controls in the second stage in a Chinese population by genotyping 8 tagging polymorphisms in ALDH1A2...
January 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28089899/progression-incidence-and-risk-factors-for-intervertebral-disc-degeneration-in-a-longitudinal-population-based-cohort-the-wakayama-spine-study
#2
Masatoshi Teraguchi, Noriko Yoshimura, Hiroshi Hashizume, Hiroshi Yamada, Hiroyuki Oka, Akihito Minamide, Keiji Nagata, Yuyu Ishimoto, Ryohei Kagotani, Hiroshi Kawaguchi, Sakae Tanaka, Toru Akune, Kozo Nakamura, Shigeyuki Muraki, Munehito Yoshida
OBJECTIVE: The present study examined the progression, incidence, and risk factors for intervertebral disc degeneration (DD) throughout the lumbar spine using magnetic resonance imaging (MRI) in a large population-based cohort. METHODS: We followed up 617 subjects for more than 4 years as part of the Wakayama Spine Study. 1) "Progression of DD" in each of the entire, upper (L1/2 to L3/4) and lower (L4/5 and L5/S1) lumbar spine was defined as Pfirrmann grade progression at follow-up in at least one disc in the affected region...
January 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28087412/pain-prediction-by-serum-biomarkers-of-bone-turnover-in-people-with-knee-osteoarthritis-an-observational-study-of-tracp5b-and-cathepsin-k-in-oa
#3
Lilian N Nwosu, Maximilian Allen, Laura Wyatt, Janet L Huebner, Victoria Chapman, David A Walsh, Virginia B Kraus
OBJECTIVES: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K, indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). METHODS: Sera and clinical data were collected from 129 people (97 with 3-year follow-up) with knee OA from the Prediction of Osteoarthritis Progression (POP) cohort. Knee OA-related outcomes in POP included: WOMAC pain, NHANES I (pain, aching and stiffness), subchondral sclerosis, and radiographically determined tibiofemoral and patellofemoral OA...
January 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28064033/altered-gait-mechanics-and-elevated-serum-pro-inflammatory-cytokines-in-asymptomatic-patients-with-mri-evidence-of-knee-cartilage-loss
#4
Shannon N Edd, Julien Favre, Katerina Blazek, Patrick Omoumi, Jessica L Asay, Thomas P Andriacchi
OBJECTIVE: To test if sagittal plane gait mechanics parameters and serum inflammation levels differ between healthy asymptomatic subjects and asymptomatic subjects with magnetic resonance imaging (MRI) evidence of cartilage loss. DESIGN: Gait mechanics and resting serum tumor necrosis factor-α (TNFα) concentrations were measured for two groups of asymptomatic subjects recruited for a previous study: Pre-Osteoarthritis (OA) subjects had MRI evidence of partial- or full-thickness knee cartilage loss in at least one compartment (n=52 (30 female), 1...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28064032/tmj-energy-densities-in-healthy-men-and-women
#5
L R Iwasaki, Y M Gonzalez, Y Liu, H Liu, M Markova, L M Gallo, J C Nickel
OBJECTIVE: Cartilage fatigue, due to mechanical work, may account for the early development of degenerative joint disease in the temporomandibular joint (TMJ), and why women are 3-times more likely to be afflicted. This study tested for gender differences in mechanical energy densities in women and men with healthy TMJs. DESIGN: Eighteen women and eighteen men gave informed consent. Research diagnostic criteria including imaging were used to ensure that subjects' TMJs were normal, without disc displacement or signs of degenerative joint disease...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28064031/frequency-of-temporomandibular-osteoarthritis-and-related-symptoms-in-a-hand-osteoarthritis-cohort
#6
Anna-Karin Abrahamsson, Margareth Kristensen, Linda Z Arvidsson, Tore K Kvien, Tore A Larheim, Ida K Haugen
OBJECTIVE: The prevalence of osteoarthritis (OA) in the temporomandibular joints (TMJs) in hand OA patients is largely unknown. Our aims were to explore 1) The frequency of TMJ-related symptoms and clinical findings; 2) The TMJ OA frequency defined by cone beam computed tomography (CBCT); and 3) The relationship between TMJ-related symptoms/clinical findings and CBCT-defined TMJ OA, in a hand OA cohort. METHODS: We calculated the frequencies of TMJ-related symptoms, clinical findings and diagnosis of TMJ OA by CBCT and clinical examination in 54 patients from the Oslo hand OA cohort (88% women, mean (range) age 71 (61-83) years)...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28099838/osteoarthritis-year-in-review-2016-biomarkers-biochemical-markers
#7
REVIEW
A Mobasheri, A-C Bay-Jensen, W E van Spil, J Larkin, M C Levesque
PURPOSE: The aim of this "Year in Review" article is to summarize and discuss the implications of biochemical marker related articles published between the Osteoarthritis Research Society International (OARSI) 2015 Congress in Seattle and the OARSI 2016 Congress in Amsterdam. METHODS: The PubMed/MEDLINE bibliographic database was searched using the combined keywords: 'biomarker' and 'osteoarthritis'. The PubMed/MEDLINE literature search was conducted using the Advanced Search Builder function (http://www...
January 2, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28049019/the-causal-role-of-smoking-on-the-risk-of-hip-or-knee-replacement-due-to-primary-osteoarthritis-a-mendelian-randomisation-analysis-of-the-hunt-study
#8
M B Johnsen, G Å Vie, B S Winsvold, J H Bjørngaard, B O Åsvold, M E Gabrielsen, L M Pedersen, A I Hellevik, A Langhammer, O Furnes, G B Flugsrud, F Skorpen, P R Romundstad, K Storheim, L Nordsletten, J A Zwart
OBJECTIVE: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be causal. METHOD: 55,745 participants of a population-based cohort were genotyped for the rs1051730 C > T single-nucleotide polymorphism (SNP), a proxy for smoking quantity among smokers. A Mendelian randomization analysis was performed using rs1051730 as an instrument to evaluate the causal role of smoking on the risk of hip or knee replacement (combined as total joint replacement (TJR))...
January 1, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043940/ultrasonographic-assessment-of-medial-femoral-cartilage-deformation-acutely-following-walking-and-running
#9
M S Harkey, J T Blackburn, H Davis, L Sierra-Arévalo, D Nissman, B Pietrosimone
OBJECTIVE: To determine the magnitude of medial femoral cartilage deformation using ultrasonography (US) following walking and running in healthy individuals. DESIGN: Twenty-five healthy participants with no history of osteoarthritis or knee injury volunteered for this study. Medial femoral cartilage thickness was assessed using US before and after three separate 30-min loading conditions: (1) walking at a self-selected speed, (2) running at a self-selected speed, and (3) sitting on a treatment table (i...
December 31, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043938/mtorc1-activation-downregulates-fgfr3-and-pth-pthrp-receptor-in-articular-chondrocytes-to-initiate-osteoarthritis
#10
H Zhang, H Wang, C Zeng, B Yan, J Ouyang, X Liu, Q Sun, C Zhao, H Fang, J Pan, D Xie, J Yang, T Zhang, X Bai, D Cai
OBJECTIVE: Articular chondrocyte activation, involving aberrant proliferation and prehypertrophic differentiation, is essential for osteoarthritis (OA) initiation and progression. Disruption of mechanistic target of rapamycin complex 1 (mTORC1) promotes chondrocyte autophagy and survival, and decreases the severity of experimental OA. However, the role of cartilage mTORC1 activation in OA initiation is unknown. In this study, we elucidated the specific role of mTORC1 activation in OA initiation, and identify the underlying mechanisms...
December 31, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043939/associations-among-meniscal-damage-meniscal-symptoms-and-knee-pain-severity
#11
Lindsey A MacFarlane, Heidi Yang, Jamie E Collins, Ali Guermazi, Morgan H Jones, Erin Teeple, Li Xu, Elena Losina, Jeffrey N Katz
OBJECTIVE: Meniscal tears occur frequently in patients with knee osteoarthritis (OA). The aim of our study was to determine whether meniscal damage identified on magnetic resonance imaging (MRI) is associated with the severity of knee pain or the frequency of meniscal symptoms in patients with knee OA. METHODS: We performed a cross-sectional study using data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial. We characterized meniscal damage hierarchically as: root tear; maceration; long and short complex or horizontal tears; and simple tears...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043937/efficacy-and-safety-of-duloxetine-in-chinese-patients-with-chronic-pain-due-to-osteoarthritis-a-randomized-double-blind-placebo-controlled-study
#12
Guochun Wang, LiQi Bi, Xiangpei Li, Zhijun Li, Dongbao Zhao, Jinwei Chen, Dongyi He, Chia-Ning Wang, Héctor Dueñas, Vladimir Skljarevski, Li Yue
OBJECTIVE: We assessed the efficacy and safety of duloxetine (60 mg, once daily), compared with placebo, during a 13-week treatment period in Chinese patients with chronic pain due to osteoarthritis (OA). DESIGN: Patients were at least 40 years old (male or female) who met American College of Rheumatology clinical and radiographic criteria for the diagnosis of OA of the knee or hip. The primary efficacy measure in this phase 3, randomized, double-blind, placebo-controlled clinical trial was assessment of pain severity by the Brief Pain Inventory (BPI) 24-hour Average Pain rating...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28043936/do-foot-ankle-assessments-assist-the-explanation-of-one-year-knee-arthroplasty-outcomes
#13
L S Gates, C J Bowen, M T Sanchez-Santos, A Delmestri, N K Arden
OBJECTIVE: Whilst a number of risk factors for poor patient reported outcomes (PROMs) following knee arthroplasty (KA) have been identified, unexplained variability still remains. The role of pre-operative foot and ankle status on such outcomes has not been investigated. The aim of this study was therefore to determine the association of clinical foot and ankle assessments with patient reported outcomes one year following KA. DESIGN: One hundred and fifteen participants from the Clinical Outcomes in Arthroplasty Study (COASt), underwent detailed foot and ankle assessments at baseline, prior to KA (2012-2014) and were followed up for self-reported outcomes one year after surgery...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28100422/osteoarthritis-year-in-review-2016-genetics-genomics-and-epigenetics
#14
REVIEW
J B J van Meurs
The purpose of this narrative review is to provide an overview of last year's publications in the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes arising from a Pubmed search on (epi)genetics in OA were identified. In addition, general developments in the fast evolving field of (epi)genetics are reviewed and relevance for the OA field is summarized. In the last 5 years, a number of genome-wide association studies have identified a modest number of genetic loci associated to OA...
December 22, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28011101/cartilage-mri-t2-%C3%A2-relaxation-time-and-perfusion-changes-of-the-knee-in-a-5-6-nephrectomy-rat-model-of-chronic-kidney-disease
#15
C-Y Wang, Y-J Peng, Y-J Hsu, H-S Lee, Y-C Chang, C-S Chang, S-W Chiang, Y-C Hsu, M-H Lin, G-S Huang
OBJECTIVE: Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2(∗) relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2(∗) as imaging biomarkers to monitor disease progression...
December 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28011100/association-between-smoking-and-risk-of-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#16
REVIEW
L Kong, L Wang, F Meng, J Cao, Y Shen
OBJECTIVE: The association between smoking and the risk for knee osteoarthritis (OA) remains controversial. Here we present a systematic review and meta-analysis of this relationship. DESIGN: Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regression models were performed to investigate potential sources of heterogeneity...
December 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28100423/osteoarthritis-year-in-review-2016-clinical
#17
REVIEW
N E Lane, K Shidara, B L Wise
Both epidemiologic and clinical research continues to be performed in osteoarthritis (OA). While epidemiologic studies identify risk factors for incident and progressive disease, clinical studies explore the role of both non-pharmacologic and pharmacologic treatments, including oral and intra-articular therapies. We performed a systematic review of the literature using PubMed for the time period between April 1, 2015 to February 22, 2016. Selected publications in the areas of both epidemiology and treatment are reviewed in this article...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28011102/variations-in-pain-and-function-before-and-after-total-knee-arthroplasty-a-comparison-between-swedish-and-australian-cohorts
#18
M M Dowsey, O Robertsson, M Sundberg, L S Lohmander, P F M Choong, A W-Dahl
OBJECTIVE: Preoperative pain and function is viewed as an important predictor of total knee arthroplasty (TKA) outcomes. We examined whether variations in pain and function outcomes existed at 12 months between two centres in Sweden and Australia, and whether this was explained by variations in patient presentation for TKA. METHODS: This was a retrospective analysis of prospectively collected data. Patients from one centre in Australia (St. Vincent's Hospital (SVH), N = 516) and in Sweden (TGB, N = 899) who underwent primary TKA between 2012 and 2013...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28011099/a-walking-program-for-people-with-severe-knee-osteoarthritis-did-not-reduce-pain-but-may-have-benefits-for-cardiovascular-health-a-phase-ii-randomised-controlled-trial
#19
J A Wallis, K E Webster, P Levinger, P J Singh, C Fong, N F Taylor
OBJECTIVE: The primary aim was to evaluate the effect of a dosed walking program on knee pain for patients with severe knee osteoarthritis (OA). Secondary aims evaluated the effects on cardiovascular health, function and quality of life. DESIGN: Participants with severe knee OA and increased cardiovascular risk were randomly assigned to a 12-week walking program of 70 min/week of at least moderate intensity, or to usual care. The primary outcome was knee pain (0-10)...
December 20, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28100421/osteoarthritis-year-in-review-2016-biology
#20
REVIEW
E N Blaney Davidson, A P M van Caam, P M van der Kraan
This review highlights a selection of literature in the area of osteoarthritis biology published between the 2015 and 2016 Osteoarthritis Research Society International (OARSI) World Congress. Highlights were selected from a pubmed search covering cartilage, bone, inflammation and pain. A personal selection was made based, amongst other things, on topics presented during the 2015 conference. This covers circadian rhythm, TGF-β signaling, autophagy, SIRT6, exercise, lubricin, TLR's, pain and NGF. Furthermore, in this review we have made an effort to connect these seemingly distant topics into one scheme of connections between them, revealing a theoretical big picture underneath...
December 17, 2016: Osteoarthritis and Cartilage
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