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Osteoarthritis and Cartilage

Edward Riordan, Sarah Robbins, Leticia Deveza, Vicky Duong, Win Min Oo, Anne Wajon, Kim Bennell, Jill Eyles, Ray Jongs, James Linklater, David Hunter
OBJECTIVE: Greater joint laxity and radial subluxation of the thumb metacarpal base have been shown to be risk factors for the development of trapeziometacarpal osteoarthritis in an asymptomatic and radiographically normal joint. Despite this, it is unknown whether joint laxity changes with disease progression from mild to severe osteoarthritis. This study aimed to investigate the relationship between joint laxity and osteoarthritis severity, using the trapeziometacarpal subluxation ratio as an indicator of joint laxity...
July 12, 2018: Osteoarthritis and Cartilage
C Huynh, D Puyraimond-Zemmour, J F Maillefert, P G Conaghan, A M Davis, K-P Gunther, G Hawker, M C Hochberg, M Kloppenburg, K Lim, L S Lohmander, N N Mahomed, L March, K Pavelka, L Punzi, E M Roos, L Sanchez-Riera, J A Singh, M E Suarez-Almazor, M Dougados, L Gossec
OBJECTIVE: To determine factors associated with orthopaedic surgeons' decision to recommend total joint replacement (TJR) in people with knee and hip osteoarthritis (OA). DESIGN: Cross-sectional study in eleven countries. For consecutive outpatients with definite hip or knee OA consulting an orthopaedic surgeon, the surgeon's indication of TJR was collected, as well as patients' characteristics including comorbidities and social situation, OA symptom duration, pain, stiffness and function (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)), joint-specific quality of life, OARSI joint space narrowing radiographic grade (0-4), and surgeons' characteristics...
July 11, 2018: Osteoarthritis and Cartilage
Bright Dube, Michael A Bowes, Elizabeth M A Hensor, Andrew Barr, Sarah R Kingsbury, Philip G Conaghan
OBJECTIVE: Bone shape and bone marrow lesions (BMLs) represent different features of MRI-detected subchondral pathology in osteoarthritis (OA). The aim of this study was to determine how these features are related and how they change in OA progression. METHODS: 600 participants from the OAI FNIH Biomarkers Initiative were included, having Kellgren-Lawrence grade 1-3, at baseline and MRI data at baseline and 24 months. The associations between 3D quantitative bone shape vectors and presence of MOAKS semi-quantitative BMLs (total BML size ≥1) were analysed for femurs and tibias using linear regression...
July 11, 2018: Osteoarthritis and Cartilage
Hirotaka Iijima, Yusuke Suzuki, Tomoki Aoyama, Masaki Takahashi
OBJECTIVE: To test the hypothesis that the interaction between low back pain (LBP) and knee pain intensity contributes to the disability level of individuals with knee osteoarthritis (OA). DESIGN: Community-dwelling participants with knee OA (Kellgren/Lawrence [K/L] grade ≥1) were enrolled. LBP and its severity were identified using questionnaires. Knee pain severity and disability level were evaluated using the Japanese Knee Osteoarthritis Measure subscale. Multiple linear regression analyses were performed to examine the effect of the LBP-knee pain interaction, an independent variable, on disability, a dependent variable...
July 9, 2018: Osteoarthritis and Cartilage
Yves Y Palad, Andrew M Leaver, Marnee J McKay, Jennifer N Baldwin, Frances Rom M Lunar, Faith Deanne Mari Caube, Joshua Burns, Milena Simic
OBJECTIVE: To report the prevalence of varus thrust and normative values for hip-knee-ankle (HKA) angle deviation across the lifespan, and to explore associations between HKA angle deviation and selected clinical factors. DESIGN: This was a cross-sectional observational study of 572 participants from the 1000 Norms Project, aged 3-101 years and who self-reported as being healthy. Video recordings (2D) of frontal plane gait were reviewed by physiotherapists for presence of knee thrust and quantification of HKA angle deviation (the difference between HKA angle at initial contact and mid-stance)...
July 5, 2018: Osteoarthritis and Cartilage
Marco T Y Schneider, Ju Zhang, Cameron G Walker, Joseph J Crisco, Arnold-Peter C Weiss, Amy L Ladd, Poul Nielsen, Thor Besier
OBJECTIVE: Characterising the morphological differences between healthy and early osteoarthritic trapeziometacarpal (TMC) joints is important for understanding osteoarthritis onset, and early detection is important for treatment and disease management. This study has two aims: first, to characterise morphological differences between healthy and early osteoarthritic TMC bones. The second aim was to determine the efficacy of using a statistical shape model (SSM) to detect early signs of osteoarthritis (OA)...
July 4, 2018: Osteoarthritis and Cartilage
Raymond Pujol, Christiane A Girard, Hélène Richard, Ida Hassanpour, Marie Pier Binette, Guy Beauchamp, Jason J McDougall, Sheila Laverty
OBJECTIVE: To measure the nerve fiber density in synovial membranes from healthy and OA equine joints and to investigate the relationship between synovial innervation and OA severity, synovial vascularity and synovitis. DESIGN: Twenty-five equine metacarpophalangeal joints were collected post-mortem. The joints were dissected and the macroscopic lesions of the articular cartilage were scored. Synovial membrane specimens (n=50) were harvested, fixed, sectioned and scored histologically...
June 26, 2018: Osteoarthritis and Cartilage
André Struglics, Staffan Larsson, Anna Pramhed, Richard Frobell, Per Swärd
OBJECTIVE: To monitor longitudinal changes of cartilage oligomeric matrix protein (COMP) in synovial fluid (sf) and serum (s) over five years after acute anterior cruciate ligament (ACL) rupture, and to compare results from two commercial COMP immunoassays. DESIGN: Bio-fluids were collected from 121 patients on 6 occasions over 5 years after acute ACL injury, and from 25 knee healthy reference subjects. Concentrations of sf- and sCOMP were measured by AnaMar (sCOMP-Ana) and by BioVendor (sf- and sCOMP-Bio) immunoassays; other biomarkers were previously assessed...
June 26, 2018: Osteoarthritis and Cartilage
L-B Jiang, D-H Su, P Liu, Y-Q Ma, Z-Z Shao, J Dong
OBJECTIVE: Nowadays, it is still questionable whether denatured collagen (DCol) can replace the native collagen (Col) as a bioactive protein in cartilage engineering. We sought to study the advantages of Col with a triple-helical structure in the collagen-based composite materials for cartilage engineering. METHODS: We presented new three-dimensional (3D) Col and DCol scaffolds with shape memory properties. The effects of Col and DCol scaffolds on rabbit chondrocytes' proliferation, adhesion, differentiation and interaction with matrix were investigated...
June 23, 2018: Osteoarthritis and Cartilage
Kaj S Emanuel, Kerstin T Mader, Mirte Peeters, Idsart Kingma, Christine M E Rustenburg, Pieter-Paul A Vergroesen, Christopher Sammon, Theodoor H Smit
OBJECTIVE: Mechanical overloading induces a degenerative cell response in the intervertebral disc. However, early changes in the extracellular matrix (ECM) are challenging to assess with conventional techniques. Fourier Transform Infrared (FTIR) imaging allows visualization and quantification of the ECM. We aim to identify markers for disc degeneration and apply these to investigate early degenerative changes due to overloading and katabolic cell activity. DESIGN: Three experiments were conducted; Exp 1...
June 20, 2018: Osteoarthritis and Cartilage
Feng Wang, Cong Zhang, Rui Shi, Zhi-Yang Xie, Lu Chen, Kun Wang, Yun-Tao Wang, Xing-Hui Xie, Xiao-Tao Wu
The adult nucleus pulposus (NP) and articular cartilage are similar in terms of their histocytological components and biomechanical functionalities, requiring a deep understanding of NP-specific markers to better evaluate stem-cell-based NP regeneration. Here, we seek to distinguish NP cells from articular chondrocytes (ACs), focusing on differences in their embryonic formation and evolutionary origin. Embryonically, NP cells are conservatively derived from the axial notochord, whereas ACs originate in a diversified manner from paraxial mesoderm and neural crest cells...
June 20, 2018: Osteoarthritis and Cartilage
Emerson Krock, Magali Millecamps, J Brooke Currie, Laura S Stone, Lisbet Haglund
OBJECTIVE: Intervertebral disc degeneration is a leading cause of chronic low back pain (LBP) but current treatment is limited. Toll-like receptors (TLRs) on disc cells are activated by endogenous extracellular matrix (ECM) fragments and modulate degeneration in vitro. This study investigated whether inhibiting TLR4 slows disc degeneration and reduces behavioral signs of LBP in vivo. DESIGN: 7-9-month old wild-type and secreted protein acidic and rich in cysteine (SPARC)-null (a model of disc degeneration and LBP) male mice were treated with TAK-242 (TLR4 inhibitor) once, and following a 10-day washout, mice were treated 3 times/week for 8 weeks...
June 18, 2018: Osteoarthritis and Cartilage
L Tsiklauri, J Werner, M Kampschulte, K W Frommer, L Berninger, M Irrgang, K Glenske, D Hose, T El Khassawna, J Pons-Kühnemann, S Rehart, S Wenisch, U Müller-Ladner, E Neumann
OBJECTIVES: Age-related bone loss is associated with bone marrow adiposity. Adipokines (e.g., visfatin, resistin, leptin) are adipocyte-derived factors with immunomodulatory properties and might influence differentiation of bone marrow-derived mesenchymal stem cells (MSC) in osteoarthritis (OA) and osteoporosis (OP). Thus, the presence of adipokines and MMPs in bone marrow and their effects on MSC differentiation were analyzed. METHODS: MSC and Ribonucleic acid (RNA) were isolated from femoral heads after hip replacement surgery of OA or osteoporotic femoral neck fracture (FF) patients...
June 14, 2018: Osteoarthritis and Cartilage
K Nakata, T Hanai, Y Take, T Osada, T Tsuchiya, D Shima, Y Fujimoto
Osteoarthritis (OA) is a potentially disabling disease whose progression is dependent on several risk factors. OA management usually involves the use of non-steroidal anti-inflammatory drugs (NSAIDs) that are the primary pharmacological treatments of choice. However, NSAIDs have often been associated with unwanted side effects. Cyclooxygenase (COX)-2 specific inhibitors, such as celecoxib, have been successfully used as an alternative in the past for OA treatment and have demonstrated fewer side effects. While abundant data are available for the clinical efficacy of drugs used for OA treatment, little is known about the disease-modifying effects of these agents...
June 8, 2018: Osteoarthritis and Cartilage
J Kemnitz, W Wirth, F Eckstein, A G Culvenor
OBJECTIVE: To determine whether loss in thigh muscle strength in women concurrent with knee osteoarthritis progression is associated with reductions of muscle anatomical cross-sectional area (ACSA) or specific-strength (i.e., isometric force÷ACSA), and to explore relationships with local adiposity. DESIGN: Female participants from the Osteoarthritis Initiative with Kellgren-Lawrence grade ≤3, thigh isometric strength measurements, and thigh magnetic resonance images at year-two (Y2) and year-four (Y4) (n = 739, age 62 ± 9 years; body mass index measurements (BMI) 28...
June 8, 2018: Osteoarthritis and Cartilage
J Scott, C M Cooper, J X Checketts, J Cutler, M Boose, J Morris, M Vassar
OBJECTIVE: Discontinuation and nonpublication are causes for concern in highly funded research areas of prevalent medical conditions. The aim of our study is to evaluate the rate of discontinuation and nonpublication in osteoarthritis randomized controlled clinical trials. DESIGN: We used the advanced search using the keyword "osteoarthritis" for phase 3 or phase 4 clinical trials in adults. Two investigators then independently screened the search results by registered title, condition, study design, and completion date...
June 5, 2018: Osteoarthritis and Cartilage
V Ulici, K L Kelley, M A Azcarate-Peril, R J Cleveland, R B Sartor, T A Schwartz, R F Loeser
OBJECTIVE: To determine the contribution of the gut microbiota to the development of injury-induced osteoarthritis (OA). DESIGN: OA was induced using the destabilized medial meniscus (DMM) model in 20 germ-free (GF) C57BL/6J male mice housed in a gnotobiotic facility and 23 strain-matched specific pathogen free (SPF) mice in 2 age groups -13.5 weeks avg age at DMM (17 SPF and 15 GF) and 43 weeks avg age at DMM (6 SPF and 5 GF). OA severity was measured using scores for articular cartilage structure (ACS), loss of safranin O (SafO) staining, osteophyte size, and synovial hyperplasia...
May 30, 2018: Osteoarthritis and Cartilage
F J Blanco, I Rego-Pérez
No abstract text is available yet for this article.
May 29, 2018: Osteoarthritis and Cartilage
D Braconi, D Giustarini, B Marzocchi, L Peruzzi, M Margollicci, R Rossi, G Bernardini, L Millucci, J A Gallagher, K-H Le Quan Sang, R Imrich, J Rovensky, M Al-Sbou, L R Ranganath, A Santucci
OBJECTIVE: The aim of this work was to assess baseline serum levels of established biomarkers related to inflammation and oxidative stress in samples from alkaptonuric subjects enrolled in SONIA1 (n = 40) and SONIA2 (n = 138) clinical trials (DevelopAKUre project). METHODS: Baseline serum levels of Serum Amyloid A (SAA), IL-6, IL-1β, TNFα, CRP, cathepsin D (CATD), IL-1ra, and MMP-3 were determined through commercial ELISA assays. Chitotriosidase activity was assessed through a fluorimetric method...
May 29, 2018: Osteoarthritis and Cartilage
K Wang, C Ding, M J Hannon, Z Chen, C K Kwoh, J Lynch, D J Hunter
OBJECTIVE: To investigate whether infrapatellar fat pad (IPFP) signal intensity (SI) alteration predicts the occurrence of knee replacement (KR) in knee osteoarthritis (OA) patients over 5 years. DESIGN: The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. They were matched by gender, age and radiographic status with control knees (n = 127). We used T2-weighted MR images to measure IPFP SI alteration using a newly developed algorithm in MATLAB...
May 26, 2018: Osteoarthritis and Cartilage
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