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Osteoarthritis and Cartilage

Kristine M Fischenich, Hannah M Pauly, Keith D Button, Ryan S Fajardo, Charles E DeCamp, Roger C Haut, Tammy L Haut Donahue
OBJECTIVE: The objective of this study was to monitor the progression of joint damage in two animal models of knee joint trauma using two non-invasive, clinically available imaging modalities. METHODS: A 3-T clinical magnet and micro-computed tomography was used to document changes immediately following injury (acute) and post injury (chronic) at time points of 4, 8, or 12 weeks. Joint damage was recorded at dissection and compared to the chronic MRI record. Fifteen Flemish Giant rabbits were subjected to a single tibiofemoral compressive impact (ACLF), and 18 underwent a combination of ACL and meniscal transection (mACLT)...
October 15, 2016: Osteoarthritis and Cartilage
Kenji Murata, Naohiko Kanemura, Takanori Kokubun, Tsutomu Fujino, Yuri Morishita, Katsuya Onitsuka, Shuhei Fujiwara, Aya Nakashima, Daisuke Shimizu, Kiyomi Takayanagi
OBJECTIVE: Joint instability induced by anterior cruciate ligament (ACL) transection is commonly considered as a predisposing factor for osteoarthritis of the knee; however, the influence of re-stabilization on the protection of articular cartilage is unclear. The aim of this study was to evaluate the effect of joint re-stabilization on articular cartilage using an instability and re-stabilization ACL transection model. DESIGN: To induce different models of joint instability, our laboratory created a controlled abnormal joint movement (CAJM) group and an anterior cruciate ligament transection group (ACL-T)...
October 15, 2016: Osteoarthritis and Cartilage
R D Chavez, G Coricor, J Perez, H-S Seo, R Serra
OBJECTIVE: We previously identified PAPSS2 as a transcriptional target of TGF-β in chondrocytes. PAPSS2 is required for proper sulfation of proteoglycans in cartilage. Defective sulfation in the matrix results in alterations in mechanical properties of the cartilage that would be expected to result in degeneration. The objective of this study was to identify factors that regulate PAPSS2 expression and compare to a known TGF-β responsive gene, PRG4. In this study, TGF-β-mediated regulation of SOX9 was characterized, and the involvement of SOX9 in regulation of PAPSS2 mRNA was investigated...
October 13, 2016: Osteoarthritis and Cartilage
Robert Gabriel Coumine Riis, Marius Henriksen, Louise Klokker, Cecilie Bartholdy, Karen Ellegaard, Elisabeth Bandak, Bjarke Brandt Hansen, Henning Bliddal, Mikael Boesen
OBJECTIVE: The aims of the present knee osteoarthritis (KOA)-study were to: i) describe and compare the changes in MRI-measures of synovitis following an exercise program preceded by an intra-articular injection of either corticosteroid or isotonic saline and ii) investigate if any of the changes in patient reported outcome measures (PROMs) were associated with changes in MRI-measures of synovitis. DESIGN: We performed a randomized, double-blinded, placebo-controlled clinical trial evaluating the effects of intra-articular corticosteroid vs...
October 13, 2016: Osteoarthritis and Cartilage
J Miotla Zarebska, A Chanalaris, C Driscoll, A Burleigh, R E Miller, A M Malfait, B Stott, T L Vincent
OBJECTIVE: The role of inflammation in structural and symptomatic osteoarthritis (OA) remains unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for attracting monocytes to sites of injury. We investigated the role of CCL2 and its receptor CCR2 in experimental OA. DESIGN: OA was induced in 10 week old male wild type, Ccl2(-/-) and Ccr2(-/-) mice, by destabilisation of the medial meniscus (DMM). RNA was extracted from whole joints at 6h and 7 days post surgery and examined by RT-PCR...
October 13, 2016: Osteoarthritis and Cartilage
Cuiyan Wu, Yan Wen, Xiong Guo, Tielin Yang, Hui Shen, Xiangding Chen, Qing Tian, Lijun Tan, Hong-Wen Deng, Feng Zhang
OBJECTIVE: Recent study observed defective autophagy in chondrocytes with Kashin-Beck Disease (KBD). To clarify the potential role of autophagy-related ATG4C gene in the development of KBD, we conducted an integrative analysis of genetic association, mRNA and protein expression of ATG4C in KBD patients. METHODS: 1,026 subjects (559 KBD patients and 467 healthy cases) were enrolled in discovery association study. 4 SNPs of ATG4C gene (rs11208030, rs4409690, rs12097658 and rs6587988) were genotyped by Sequenom MassARRAY platform...
October 11, 2016: Osteoarthritis and Cartilage
T Janvier, R Jennane, A Valery, K Harrar, M Delplanque, C Lelong, D Loeuille, H Toumi, E Lespessailles
OBJECTIVES: To examine whether trabecular bone texture (TBT) parameters assessed on computed radiographs could predict knee osteoarthritis (OA) progression. METHODS: This study was performed using data from the Osteoarthritis Initiative. 1647 knees in 1124 patients had bilateral fixed flexion radiographs acquired 48 months apart. Images were semi-automatically segmented to extract a patchwork of regions of interest (ROI). A fractal texture analysis was performed using different methods...
October 11, 2016: Osteoarthritis and Cartilage
Zemin Li, Xiaolin Wang, Hehai Pan, Hao Yang, Xiang Li, Kuibo Zhang, Hua Wang, Zhaomin Zheng, Hui Liu, Jianru Wang
OBJECTIVE: This study was to investigate whether resistin induces the expression of CCL4 during IVDD and whether Toll-like receptor-4 (TLR-4) and the NF-κB signaling pathway are involved in this process. METHODS: The expression pattern of resistin and CCL4 in different degenerated human NP tissues were measured by qPCR; Effect of resistin on the migration of macrophages was measured by cell migration assay. Resistin-induced CCL4 expression were analyzed by qPCR, ELISA and cell immunofluorescence...
October 10, 2016: Osteoarthritis and Cartilage
Robert Gabriel Coumine Riis, Henrik Gudbergsen, Ole Simonsen, Marius Henriksen, Nasir Al-Mashkur, Mikkel Eld, Kristian Kjær Petersen, Olga Kubassova, Anne C Bay Jensen, Janus Damm, Henning Bliddal, Lars Arendt-Nielsen, Mikael Ploug Boesen
OBJECTIVES: To investigate the association between MRI, macroscopic and histological assessments of synovitis in end-stage knee osteoarthritis (KOA). METHODS: Synovitis of end-stage osteoarthritic knees was assessed using non-contrast-enhanced (CE), CE-MRI and dynamic-CE (DCE)-MRI prior to total knee replacement and correlated with microscopic and macroscopic assessments of synovitis obtained intraoperatively. Multiple bivariate correlations were used with a pre-specified threshold of 0...
October 10, 2016: Osteoarthritis and Cartilage
Takashi Nishida, Satoshi Kubota, Eriko Aoyama, Nobuyasu Yamanaka, Karen M Lyons, Masaharu Takigawa
OBJECTIVE: CCN family protein 2/connective tissue growth factor (CCN2/CTGF) promotes cartilage regeneration in experimental osteoarthritis (OA) models. However, CCN2 production is very low in articular cartilage. The aim of this study was to investigate whether or not CCN2 was promoted by cultured chondrocytes treated with low-intensity pulsed ultrasound (LIPUS) and to clarify its mechanism. METHODS: Human chondrocytic cell line HCS-2/8, rat primary epiphyseal and articular cartilage cells, and Ccn2-deficient chondrocytes that impaired chondrocyte differentiation, were treated with LIPUS for 20 min at 3...
October 8, 2016: Osteoarthritis and Cartilage
Kade L Paterson, Kim L Bennell, Tim V Wrigley, Ben R Metcalf, Jessica Kasza, Rana S Hinman
OBJECTIVE: To validate simple criteria that distinguish flat flexible from stable supportive walking shoes by comparing their effects on the knee adduction moment (KAM) in people with medial knee osteoarthritis (OA). DESIGN: This was a cross-sectional biomechanical study. We proposed five criteria to differentiate flat flexible from stable supportive shoes, and selected three pairs of shoes representing each class for biomechanical testing. 28 participants aged ≥50 years with symptomatic medial knee OA underwent gait analysis barefoot and wearing each of the six selected shoes, in random order...
October 8, 2016: Osteoarthritis and Cartilage
Alison H Chang, Joan S Chmiel, Orit Almagor, Ali Guermazi, Pottumarthi V Prasad, Kirsten C Moisio, Laura Belisle, Yunhui Zhang, Karen Hayes, Leena Sharma
OBJECTIVE: Knee sagittal dynamic joint stiffness (DJS) describes the biomechanical interaction between change in external knee flexion moment and flexion angular excursion during gait. In theory, greater DJS may particularly stress the patellofemoral (PF) compartment and thereby contribute to PF osteoarthritis (OA) worsening. We hypothesized that greater baseline knee sagittal DJS is associated with PF cartilage damage worsening 2 years later. METHODS: Participants all had OA in at least one knee...
October 8, 2016: Osteoarthritis and Cartilage
Geoffrey J Kerr, Matthew R McCann, Jennifer K Branch, Anusha Ratneswaran, Michael A Pest, David W Holdsworth, Frank Beier, S Jeffrey Dixon, Cheryle A Séguin
OBJECTIVE: Whole-body vibration (WBV) platforms are commercially available devices that are used clinically as potential treatments for numerous musculoskeletal conditions based on their reported ability to increase bone mineral density and muscle strength. Despite widespread use, there is an alarming lack of understanding of the direct effects of WBV on joint health. Previous work by our lab demonstrated that repeated exposure to WBV using protocols that model those used clinically, induces intervertebral disc degeneration and osteoarthritis-like damage in the knee of skeletally mature, male mice of a single outbred strain (CD-1)...
October 6, 2016: Osteoarthritis and Cartilage
Laura A Wyatt, Bryan J Moreton, Paul I Mapp, Deborah Wilson, Roger Hill, Eamonn Ferguson, Brigitte E Scammell, David A Walsh
OBJECTIVE: Osteoarthritis (OA) is a heterogeneous, multi-tissue disease. We hypothesised that different histopathological features characterise different stages during knee OA progression, and that discrete subgroups can be defined based on validated measures of OA histopathological features. DESIGN: Medial tibial plateaux and synovium were from 343 post-mortem (PM) and 143 OA arthroplasty donations. A `chondropathy/osteophyte' group (n=217) was classified as PM cases with osteophytes or macroscopic medial tibiofemoral chondropathy lesions ≥ grade 3 to represent pre-surgical (early) OA...
October 6, 2016: Osteoarthritis and Cartilage
Uchechukwuka D Monu, Caroline D Jordan, Bonnie L Samuelson, Brian A Hargreaves, Garry E Gold, Emily J McWalter
PURPOSE: To identify focal lesions of elevated MRI T2 and T1ρ relaxation times in articular cartilage of an ACL-injured group using a novel cluster analysis technique. MATERIALS AND METHODS: Eighteen ACL-injured patients underwent 3T MRI T2 and T1ρ relaxometry at baseline, six months and one year and six healthy volunteers at baseline, one day and one year. Clusters of contiguous pixels above or below T2 and T1ρ intensity and area thresholds were identified on a projection map of the 3D femoral cartilage surface...
October 5, 2016: Osteoarthritis and Cartilage
J J Rongen, M M Rovers, T G van Tienen, P Buma, G Hannink
OBJECTIVE: The primary objective was to assess whether patients with knee osteoarthritis and whom undergo arthroscopic meniscectomy have an increased risk for future knee replacement surgery. DESIGN: Data used were obtained from the Osteoarthritis Initiative (OAI) study. SETTING: Participants were enrolled, in four clinical centers, between February 2004 and May 2006 and were followed up on an annual basis up to and including 108-months from enrollment...
October 3, 2016: Osteoarthritis and Cartilage
M D Crema, F W Roemer, L Li, R C Alexander, I P Chessell, A D Dudley, R Karlsten, L B Rosen, A Guermazi
OBJECTIVE: To compare different semiquantitative and quantitative methods using both non-enhanced and gadolinium-enhanced magnetic resonance imaging (MRI) techniques for the assessment of synovitis in knee osteoarthritis (OA). METHODS: Knees with end-stage clinical OA in patients undergoing total knee replacement surgery were included in this cross-sectional study. MRI was performed on all knees. Standard non-enhanced and gadolinium-enhanced sequences were acquired...
September 30, 2016: Osteoarthritis and Cartilage
A G Culvenor, B E Øiestad, I Holm, R B Gunderson, K M Crossley, M A Risberg
OBJECTIVE: To prospectively evaluate the relationship between the presence or persistence of anterior knee pain (AKP) during the first 2-years following anterior cruciate ligament reconstruction (ACLR) and patellofemoral osteoarthritis (PFOA) at 15- and 20-years. DESIGN: This study was ancillary to a long-term prospective cohort study of 221 participants following bone-patellar-tendon-bone ACLR. AKP was assessed at 1- and 2-years post-ACLR using part of the Cincinnati knee score with an additional pain location question (persistence defined as presence at both follow-ups)...
September 30, 2016: Osteoarthritis and Cartilage
F R Bhatti, A Mehmood, N Latief, S Zahra, H Cho, S N Khan, S Riazuddin
OBJECTIVE: Oxidative stress is a major obstacle against cartilage repair in osteoarthritis (OA). Anti-oxidant agents can play a vital role in addressing this issue. We evaluated the effect of Vitamin E preconditioning in improving the potential of mesenchymal stem cells (MSCs) to confer resistance against oxidative stress prevailing during OA. METHODS: Vitamin E pretreated MSCs were exposed to oxidative stress in vitro by hydrogen peroxide (H2O2) and also implanted in surgically-induced rat model of OA...
September 30, 2016: Osteoarthritis and Cartilage
A C Moore, D L Burris
OBJECTIVE: During exercise, cartilage recovers interstitial fluid lost during inactivity, which explains how tissue thickness and joint space are maintained over time. This recovery phenomenon is currently explained by a combination of osmotic swelling during intermittent bath exposure and sub-ambient pressurization during unloading. This paper tests an alternate hypothesis that cartilage can retain and recover interstitial fluid in the absence of bath exposure and unloading when physiological hydrodynamics are present...
September 30, 2016: Osteoarthritis and Cartilage
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