journal
MENU ▼
Read by QxMD icon Read
search

Osteoarthritis and Cartilage

journal
https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#1
Martijn H van den Bosch, Arjen B Blom, Vardit Kram, Azusa Maeda, Sheena Sikka, Yankel Gabet, Tina M Kilts, Wim B van den Berg, Peter L van Lent, Peter M van der Kraan, Marian F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis. Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental osteoarthritis in wild type and Wisp1(-/-) mice. METHODS: Wild type and Wisp1(-/-) mice were aged or experimental osteoarthritis was induced with intraarticular collagenase injection, destabilization of the medial meniscus or anterior cruciate ligament transection...
July 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28716756/cartilage-specific-deletion-of-alk5-gene-results-in-a-progressive-osteoarthritis-like-phenotype-in-mice
#2
Quan Wang, Qiaoyan Tan, Wei Xu, Huabing Qi, Di Chen, Siru Zhou, Zhenhong Ni, Liang Kuang, Jingyuan Guo, Junlan Huang, Xianxing Wang, Zuqiang Wang, Nan Su, Liang Chen, Bo Chen, Wanling Jiang, Yu Gao, Hangang Chen, Xiaolan Du, Yangli Xie, Lin Chen
OBJECTIVE: Previous studies have shown that Transforming growth factor-β (TGF-β)/TGFβRII-Smad3 signaling is involved in articular cartilage homeostasis. However, the role of TGF-β/ALK5 signaling in articular cartilage homeostasis has not been fully defined. In this study, a combination of in vitro and in vivo approaches was used to elucidate the role of ALK5 signaling in articular cartilage homeostasis and the development of osteoarthritis (OA). DESIGN: Mice with inducible cartilage-specific deletion of Alk5 were generated to assess the role of ALK5 in OA development...
July 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28711584/biomarkers-reflect-differences-in-osteoarthritis-phenotypes-of-the-lumbar-spine-the-johnston-county-osteoarthritis-project
#3
Adam P Goode, Amanda E Nelson, Virginia B Kraus, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II)...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28711583/incidence-of-symptomatic-osteochondritis-dissecans-lesions-of-the-knee-a-population-based-study-in-olmsted-county
#4
A Pareek, T L Sanders, I T Wu, D R Larson, D B F Saris, A J Krych
OBJECTIVE: To (1) define the population-based incidence of Osteochondritis dissecans (OCD) lesions of the knee using the population of Olmsted County, (2) examine trends over time, and (3) evaluate changes in the rate of surgical management. METHOD: The study population included 302 individuals who were diagnosed with knee OCD lesions between January 1, 1976 and December 31, 2014. The complete medical records were reviewed to confirm diagnosis and to extract injury and treatment details...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28711582/a-novel-wnt-pathway-inhibitor-sm04690-for-the-treatment-of-moderate-to-severe-osteoarthritis-of-the-knee-results-of-a-24-week-randomized-controlled-phase-1-study
#5
Yusuf Yazici, Timothy E McAlindon, Roy Fleischmann, Allan Gibofsky, Nancy E Lane, Alan J Kivitz, Nebojsa Skrepnik, Eddie Armas, Christopher J Swearingen, Anita DiFrancesco, Jeyanesh R S Tambiah, John Hood, Marc C Hochberg
OBJECTIVE: To assess the safety, pharmacokinetics, and exploratory efficacy of SM04690, a novel Wnt pathway inhibitor, as a potential disease modifying treatment for knee OA. DESIGN: Subjects with Kellgren-Lawrence grade 2-3 knee OA were randomized in successive dose-escalation cohorts to receive a knee intra-articular injection with 0.03, 0.07, or 0.23 mg SM04690, or placebo (PBO) (4:1 ratio). Safety, pharmacokinetics, efficacy (WOMAC Total/Function/Pain, Pain VAS, Physician Global Assessment [MDGA], and OMERACT-OARSI Response), OA-related biomarker (P1NP, ß-CTX, and COMP), and radiographic/imaging data were collected at baseline and during 24-week follow-up...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28710026/systematic-review-of-the-impact-of-osteoarthritis-on-health-outcomes-for-comorbid-disease-in-older-people
#6
REVIEW
Lynne Parkinson, Debra L Waters, Linѐl Franck
OBJECTIVE: A systematic review was undertaken examining the impact of comorbid osteoarthritis on health outcomes for people aged 50 years or older with cardiovascular disease, diabetes or obesity. DESIGN: The protocol is registered in PROSPERO (CRD42015023417). Relevant electronic databases and grey literature were systematically searched for studies published in English between January 2005 and December 2016. Two reviewers independently screened studies for selection using predetermined inclusion and exclusion criteria, and independently completed methodological quality review...
July 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28705606/regenerative-approaches-for-cartilage-repair-in-the-treatment-of-osteoarthritis
#7
REVIEW
M Li, R Xiao, J B Li, Q Zhu
Osteoarthritis (OA) as a debilitating affliction of joints currently affects millions of people and remains an unsolved problem. The disease involves multiple cellular and molecular pathways that converge on the progressive destruction of cartilage. Activation of cartilage regenerative potential and specific targeting pathogenic mediators have been the major focus of research efforts aimed at slowing the progression of cartilage degeneration and preserve joint function. This review will summarize recent key discoveries toward better understanding of the complex mechanisms behind OA development and highlight the latest advances in basic and clinical research in the approach for cartilage regeneration...
July 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28705605/age-of-menarche-is-associated-with-knee-joint-replacement-due-to-primary-osteoarthritis-the-hunt-study-and-the-norwegian-arthroplasty-register
#8
A I Hellevik, L Nordsletten, M B Johnsen, A M Fenstad, O Furnes, K Storheim, J A Zwart, G Flugsrud, A Langhammer
OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis...
July 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28698106/longitudinal-change-in-thigh-muscle-strength-prior-to-and-concurrent-with-symptomatic-and-radiographic-knee-osteoarthritis-progression-data-from-the-osteoarthritis-initiative
#9
J Kemnitz, W Wirth, F Eckstein, A Ruhdorfer, A G Culvenor
OBJECTIVE: To investigate whether symptomatic and/or radiographic knee osteoarthritis (KOA) progression is associated with prior and/or concurrent change in thigh muscle strength in men or women. DESIGN: Osteoarthritis Initiative (OAI) participants with isometric muscle strength measurements at baseline, 2- and 4-year follow-up (n = 1785: 1016 women) were grouped into 1) those with vs without symptomatic progression (i.e., increase ≥9 in WOMAC-pain [scale: 0-100]); and 2) those with vs without radiographic progression (i...
July 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28698105/magnetic-resonance-imaging-mri-defined-cartilage-degeneration-and-joint-pain-are-associated-with-poor-physical-function-in-knee-osteoarthritis-the-oulu-knee-osteoarthritis-study
#10
P Kaukinen, J Podlipská, A Guermazi, J Niinimäki, P Lehenkari, F W Roemer, M T Nieminen, J M Koski, S Saarakkala, J P A Arokoski
OBJECTIVE: The main aim was to investigate the associations between Magnetic Resonance Imaging (MRI)-defined structural pathologies of the knee and physical function. DESIGN: A cohort study with frequency matching on age and sex with eighty symptomatic subjects with knee pain and suspicion or diagnosis of knee osteoarthritis (OA) and 57 asymptomatic subjects was conducted. The subjects underwent knee MRI, and the severity of structural changes was graded by MRI Osteoarthritis Knee Score (MOAKS) in separate knee locations...
July 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28694081/deletion-of-12-15-lipoxygenase-accelerates-the-development-of-aging-associated-and-instability-induced-osteoarthritis
#11
L Habouri, F E El Mansouri, Y Ouhaddi, B Lussier, J-P Pelletier, J Martel-Pelletier, M Benderdour, H Fahmi
OBJECTIVE: 12/15-Lipoxygenase (12/15-LOX) catalyzes the generation of various anti-inflammatory lipid mediators, and has been implicated in several inflammatory and degenerative diseases. However, there is currently no evidence that 12/15-LOX has a role in osteoarthritis (OA). The aim of this study was to investigate the role of 12/15-LOX in the pathogenesis of OA. METHODS: The development of aging-associated and destabilization of the medial meniscus (DMM)-induced OA were compared in 12/15-LOX-deficient (12/15-LOX-/-) and wild-type (WT) mice...
July 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28689920/relationship-between-weight-loss-in-obese-knee-osteoarthritis-patients-and-serum-biomarkers-of-cartilage-breakdown-secondary-analyses-of-a-randomised-trial
#12
E M Bartels, Y Henrotin, H Bliddal, P Centonze, M Henriksen
OBJECTIVE: To explore effects of weight loss and maintenance on serum cartilage biomarkers denaturation neoepitope for Collagen2 (Coll2-1) and Fibulin3 fragment (Fib3-2), as well as correlations between Coll2-1 and Fib3-2 and symptomatic improvement, in a knee osteoarthritis (KOA) population. DESIGN: 192 obese KOA patients followed a 16 week weight loss intervention and 52 weeks weight maintenance (ClinicalTrials.gov identifier: NCT00655941). Assessments were at 0, 8, 16 and 68 weeks...
July 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28668542/cd56-cd16-natural-killer-cells-expressing-the-inflammatory-protease-granzyme-a-are-enriched-in-synovial-fluid-from-patients-with-osteoarthritis
#13
P Jaime, N García-Guerrero, R Estella, J Pardo, F García-Álvarez, L Martinez-Lostao
OBJECTIVE: Natural killer (NK) cells have been involved in the pathology of different inflammatory and autoimmune disorders. Inflammation is an important regulator of osteoarthritis (OA), but the molecular and cellular mechanisms regulating this process are not well defined. DESIGN: To understand the role of NK cells in OA, we have compared the phenotype (CD56 subsets and perforin and granzyme expression) and cytotoxic function of NK cells in peripheral blood and synovial fluid from patients with OA undergoing total knee arthroplasty...
June 29, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28668541/non-linear-optical-microscopy-as-a-novel-quantitative-and-label-free-imaging-modality-to-improve-the-assessment-of-tissue-engineered-cartilage-tec
#14
A Islam, E I Romijn, M B Lilledahl, I Martinez-Zubiaurre
OBJECTIVE: Current systems to evaluate outcomes from tissue-engineered cartilage (TEC) are sub-optimal. The main purpose of our study was to demonstrate the use of second harmonic generation (SHG) microscopy as a novel quantitative approach to assess collagen deposition in laboratory made cartilage constructs. METHODS: Scaffold-free cartilage constructs were obtained by condensation of in vitro expanded Hoffa's fat pad derived stromal cells (HFPSCs), incubated in the presence or absence of chondrogenic growth factors (GF) during a period of 21 d...
June 29, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28648741/the-importance-of-dose-in-land-based-supervised-exercise-for-people-with-hip-osteoarthritis-a-systematic-review-and-meta-analysis
#15
REVIEW
T Moseng, H Dagfinrud, G Smedslund, N Østerås
PURPOSE: To compare effects of land-based exercise programmes with high vs low or uncertain compliance with dose recommendations among people with hip osteoarthritis (OA). DESIGN: A systematic review with meta-analyses of supervised exercise programmes in people with symptomatic hip OA was conducted. Dose of the exercise interventions was evaluated according to the American College of Sports Medicine's (ACSM) recommendations for developing and maintaining cardiorespiratory fitness, muscular strength and flexibility in healthy adults...
June 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28648740/patellofemoral-morphology-and-alignment-reference-values-and-dose-response-patterns-for-the-relation-to-mri-features-of-patellofemoral-osteoarthritis
#16
E M Macri, D T Felson, Y Zhang, A Guermazi, F W Roemer, K M Crossley, K M Khan, J J Stefanik
OBJECTIVE: We aimed to (1) determine reference values for trochlear morphology and patellofemoral (PF) alignment in adults without magnetic resonance imaging (MRI)-defined PF full thickness cartilage damage or knee pain; and (2) evaluate dose-response patterns for these measures with prevalent MRI-defined PF structural damage and/or knee pain. DESIGN: The Framingham Community Cohort is a population-based sample of ambulatory adults aged ≥50 years. We evaluated six morphology and alignment measures using MRI (n = 985), and reported reference values (mean ± 2SD) in a subsample without MRI-defined PF full thickness cartilage damage or knee pain (n = 563)...
June 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28647467/reliability-and-measurement-error-of-the-osteoarthritis-research-society-international-oarsi-recommended-performance-based-tests-of-physical-function-in-people-with-hip-and-knee-osteoarthritis
#17
F Dobson, R S Hinman, M Hall, C J Marshall, T Sayer, C Anderson, N Newcomb, P W Stratford, K L Bennell
OBJECTIVE: To estimate the reliability and measurement error of performance-based tests of physical function recommended by the Osteoarthritis Research Society International (OARSI) in people with hip and/or knee osteoarthritis (OA). DESIGN: Prospective repeated measures between independent raters within a session and within-rater over a week interval. Relative reliability was estimated for 51 people with hip and/or knee OA (mean age 64.5 years, standard deviation (SD) 6...
June 22, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28647469/intra-articular-injection-of-microrna-140-mirna-140-alleviates-osteoarthritis-oa-progression-by-modulating-extracellular-matrix-ecm-homeostasis-in-rats
#18
H-B Si, Y Zeng, S-Y Liu, Z-K Zhou, Y-N Chen, J-Q Cheng, Y-R Lu, B Shen
OBJECTIVE: Disruptions of extracellular matrix (ECM) homeostasis are key events in the pathogenesis of osteoarthritis (OA). MicroRNA-140 (miRNA-140) is expressed specifically in cartilage and regulates ECM-degrading enzymes. Our objective in this study was to determine if intra-articular injection of miRNA-140 can attenuate OA progression in rats. DESIGN: miRNA-140 levels in human normal and OA cartilage derived chondrocytes and synovial fluid were assessed by polymerase chain reaction (PCR)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28647468/influence-of-rabbit-notochordal-cells-on-symptomatic-intervertebral-disc-degeneration-anti-angiogenic-capacity-on-human-endothelial-cell-proliferation-under-hypoxia
#19
W-K Kwon, H J Moon, T-H Kwon, Y-K Park, J H Kim
OBJECTIVES: Symptomatic degenerative disc disease (DDD) is associated with neovascularization and nerve ingrowth into intervertebral discs (IVDs). Notochordal cells (NCs) are key cells that may lead to regeneration of IVDs. However, their activities under conditions of hypoxia, the real environment of IVD, are not well known. We hypothesized that NCs may inhibit neovascularization by interacting with endothelial cells (ECs) under hypoxia. DESIGN: Human IVDs were isolated and cultured to produce nucleus pulposus (NP) cell conditioned medium (NPCM)...
June 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28642164/joint-loading-and-proximal-tibia-subchondral-trabecular-bone-microarchitecture-differ-with-walking-gait-patterns-in-end-stage-knee-osteoarthritis
#20
B C Roberts, L B Solomon, G Mercer, K J Reynolds, D Thewlis, E Perilli
OBJECTIVES: To (1) stratify subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA) patients; (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among subgroups. DESIGN: Twenty-five knee OA patients undergoing total knee arthroplasty (TKA) had pre-operative gait analysis. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four tibial condylar regions of interest...
June 20, 2017: Osteoarthritis and Cartilage
journal
journal
20209
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"