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Osteoarthritis and Cartilage

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https://www.readbyqxmd.com/read/28445775/changes-in-social-isolation-and-loneliness-following-total-hip-and-knee-arthroplasty-longitudinal-analysis-of-the-english-longitudinal-study-of-ageing-elsa-cohort
#1
Toby O Smith, Jack R Dainty, Alex Macgregor
OBJECTIVE: To determine the prevalence and change in social isolation and loneliness in people before and after THA and TKA in England. DESIGN: The English Longitudinal Study of Ageing dataset, a prospective study of community-dwelling older adults, was used to identify people who had undergone primary THA or TKA because of osteoarthritis. Social isolation was assessed using the ELSA Social Isolation Index. Loneliness was evaluated using the Revised University of California, Los Angeles (UCLA) Loneliness Scale...
April 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28433815/patterns-and-predictors-of-persistent-opioid-use-following-hip-or-knee-arthroplasty
#2
Seoyoung C Kim, Niteesh Choudhry, Jessica M Franklin, Katsiaryna Bykov, Matthias Eikermann, Joyce Lii, Michael A Fischer, Brian T Bateman
OBJECTIVE: The relationship between arthroplasty and long-term opioid use in patients with knee or hip osteoarthritis is not well studied. We examined the prevalence, patterns and predictors of persistent opioid use after hip or knee arthroplasty. METHOD: Using claims data (2004-2013) from a U.S. commercial health plan, we identified adults who underwent hip or knee arthroplasty and filled ≥1 opioid prescription within 30 days after the surgery. We defined persistent opioid users as patients who filled ≥1 opioid prescription every month during the 1-year postoperative period based on group-based trajectory models...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28433814/synovial-fluid-pro-inflammatory-profile-differs-according-to-the-characteristics-of-knee-pain
#3
Ying Ying Leung, Janet L Huebner, Benjamin Haaland, Steven Bak Siew Wong, Virginia Byers Kraus
OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchicine for symptomatic knee OA. Severity of pain of the more symptomatic knee was assessed by NHANES-I criterion and WOMAC pain index. Pains on movement and at rest were self-reported on an 11-point Likert scale. Severity of radiographic tibiofemoral OA was assessed by Kellgren and Lawrence (KL) grade...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28396243/mechanical-force-mediated-pathological-cartilage-thinning-is-regulated-by-necroptosis-and-apoptosis
#4
C Zhang, S Lin, T Li, Y Jiang, Z Huang, J Wen, W Cheng, H Li
OBJECTIVE: This study aimed to identify the mechanisms underlying mandibular chondrocyte cell death and cartilage thinning in response to mechanical force. MATERIAL AND METHODS: An in vivo model (compressive mechanical force) and an in vitro model (TNF-α+cycloheximide) were used to induce mandibular chondrocyte necroptosis. Hematoxylin and eosin staining and transmission electron microscopy were used to assess histological and subcellular changes in mandibular chondrocyte...
April 7, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28385483/analgesic-use-and-risk-of-recurrent-falls-in-participants-with-or-at-risk-of-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#5
W-H Lo-Ciganic, L Floden, J K Lee, E L Ashbeck, L Zhou, C Chinthammit, A W Purdy, C K Kwoh
OBJECTIVE: Few studies have compared the risk of recurrent falls across different types of analgesic use, and were limited to adjust for potential confounders (e.g., pain/depression severity). We aimed to assess analgesic use and the subsequent risk of recurrent falls, among participants with or at risk of knee osteoarthritis (OA). METHODS: A longitudinal analysis included 4231 participants aged 45-79 years at baseline with 4-year follow-up from the Osteoarthritis Initiative (OAI) cohort study...
April 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28373131/cartilage-oligomeric-matrix-protein-forms-protein-complexes-with-synovial-lubricin-via-non-covalent-and-covalent-interactions
#6
S A Flowers, S Kalamajski, L Ali, L I Björkman, J R Raj, A Aspberg, N G Karlsson, C Jin
OBJECTIVE: Understanding the cartilage surface structure, lost in arthritic disease, is essential for developing strategies to effectively restore it. Given that adherence of the lubricating protein, lubricin, to the cartilage surface is critical for boundary lubrication, an interaction with cartilage oligomeric matrix protein (COMP) was investigated. COMP, an abundant cartilage protein, is known to be important for matrix formation. DESIGN: Synovial fluid (SF) from arthritic patients was used to detect possible COMP-lubricin complexes by immunological methods...
April 1, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28365462/toward-understanding-the-role-of-cartilage-particulates-in-synovial-inflammation
#7
A M Silverstein, R M Stefani, E Sobczak, E L Tong, M G Attur, R P Shah, J C Bulinski, G A Ateshian, C T Hung
OBJECTIVE: Arthroscopy with lavage and synovectomy can remove tissue debris from the joint space and the synovial lining to provide pain relief to patients with osteoarthritis (OA). Here, we developed an in vitro model to study the interaction of cartilage wear particles with fibroblast-like synoviocytes (FLS) to better understand the interplay of cartilage particulates with cytokines on cells of the synovium. METHOD: In this study sub-10 μm cartilage particles or 1 μm latex particles were co-cultured with FLS ±10 ng/mL interleukin-1α (IL-1α) or tumor necrosis factor-α (TNF-α)...
March 30, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28351706/baseline-meniscal-extrusion-associated-with-incident-knee-osteoarthritis-after-30-months-in-overweight-and-obese-women
#8
J A van der Voet, J Runhaar, P van der Plas, D Vroegindeweij, E H Oei, S M A Bierma-Zeinstra
OBJECTIVE: To investigate the association between baseline meniscal extrusion and the incidence of knee osteoarthritis (KOA) after 30 months in a high-risk population of overweight and obese women, free of clinical and radiological KOA at baseline. METHODS: 407 middle-aged overweight women (body mass index - BMI ≥ 27 kg/m(2)) were evaluated at baseline and after 30 months of follow-up. Meniscal extrusion was defined as grade ≥2 on MRI according to MRI Osteoarthritis Knee Score (MOAKS)...
March 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28351705/subregional-laminar-cartilage-mr-spin-spin-relaxation-times-t2-in-osteoarthritic-knees-with-and-without-medial-femorotibial-cartilage-loss-data-from-the-osteoarthritis-initiative-oai
#9
W Wirth, S Maschek, P Beringer, F Eckstein
OBJECTIVE: To explore whether subregional laminar femorotibial cartilage spin-spin relaxation time (T2) is associated with subsequent radiographic progression and cartilage loss and/or whether one-year change in subregional laminar femorotibial cartilage T2 is associated with concurrent progression in knees with established radiographic OA (ROA). METHODS: In this case-control study, Osteoarthritis Initiative (OAI) knees with medial femorotibial progression were selected based on one-year loss in both quantitative cartilage thickness Magnetic resonance imaging (MRI) and radiographic joint space width (JSW)...
March 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28336453/a-bioinformatic-analysis-of-micrornas-role-in-osteoarthritis
#10
L Cong, Y Zhu, G Tu
OBJECTIVE: To evaluate the underlying function of microRNAs (miRNAs) in osteoarthritis (OA). DESIGN: A bioinformatic analysis of miRNAs-OA studies was completed in multiple databases. All identified articles were assessed using specific inclusion and exclusion criteria (Eligible case-control studies for the present study included those which investigated miRNAs differential expression in cartilage tissues and cells of OA and controls. Abstracts, case reports, conference presentations, editorials, and expert opinions were excluded...
March 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28336454/cryoneurolysis-to-treat-the-pain-and-symptoms-of-knee-osteoarthritis-a-multicenter-randomized-double-blind-sham-controlled-trial
#11
R Radnovich, D Scott, A T Patel, R Olson, V Dasa, N Segal, N E Lane, K Shrock, J Naranjo, K Darr, R Surowitz, J Choo, A Valadie, R Harrell, N Wei, S Metyas
OBJECTIVE: Evaluate the efficacy and safety/tolerability of cryoneurolysis for reduction of pain and symptoms associated with knee osteoarthritis (OA). DESIGN: Randomized, double-blind, sham-controlled, multicenter trial with a 6-month follow-up in patients with mild-to-moderate knee OA. Patients were randomized 2:1 to cryoneurolysis targeting the infrapatellar branch of the saphenous nerve (IPBSN) or sham treatment. The primary endpoint was the change from baseline to Day 30 in the Western Ontario and McMaster Osteoarthritis Index (WOMAC) pain score adjusted by the baseline score and site...
March 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28336452/the-relationship-of-bone-properties-using-high-resolution-peripheral-quantitative-computed-tomography-to-radiographic-components-of-hip-osteoarthritis
#12
M H Edwards, J Paccou, K A Ward, K A Jameson, C Moss, J Woolston, M K Javaid, C Cooper, E M Dennison
OBJECTIVE: Positive associations between radiographic osteoarthritis (OA) and areal bone mineral density (BMD) have been demonstrated and appear strongest when bony features of OA are considered. To date, these associations have not been assessed using HRpQCT. DESIGN: A total of 318 participants (170 men and 148 women), aged 72.1-81.4 years from a non-selected cohort, underwent HRpQCT of the distal radius and tibia along with hip radiography. Differences in bone microarchitecture were assessed between those with and without osteophytes, sclerosis or joint space narrowing (JSN) in either hip...
March 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28323138/impact-of-a-daily-exercise-dose-on-knee-joint-cartilage-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-in-healthy-animals
#13
REVIEW
A Bricca, C B Juhl, A J Grodzinsky, E M Roos
OBJECTIVE: To investigate the impact of a daily exercise dose on cartilage composition and thickness, by conducting a systematic review of randomized controlled trials (RCTs) involving healthy animals. METHODS: A narrative synthesis of the effect of a daily exercise dose on knee cartilage aggrecan, collagen and thickness was performed. A subset of studies reporting sufficient data was combined in meta-analysis using a random-effects model. Meta-regression analyses were performed to investigate the impact of covariates...
March 18, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28323137/defects-in-chondrocyte-maturation-and-secondary-ossification-in-mouse-knee-joint-epiphyses-due-to-snorc-deficiency
#14
J Heinonen, F-P Zhang, C Surmann-Schmitt, S Honkala, M Stock, M Poutanen, A-M Säämänen
OBJECTIVE: The role of Snorc, a novel cartilage specific transmembrane proteoglycan, was studied during skeletal development using two Snorc knockout mouse models. Hypothesizing that Snorc, like the other transmembrane proteoglycans, may be a coreceptor, we also studied its interaction with growth factors. METHODS: Skeletal development was studied in wild type (WT) and Snorc knockout mice during postnatal development by whole mount staining, X-ray imaging, histomorphometry, immunohistochemistry and qRT-PCR...
March 18, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28323139/inflammation-and-post-operative-recovery-in-patients-undergoing-total-knee-arthroplasty-secondary-analysis-of-a-randomized-controlled-trial
#15
A Langkilde, T L Jakobsen, T Q Bandholm, J Eugen-Olsen, T Blauenfeldt, J Petersen, O Andersen
OBJECTIVE: Reduced function persists for many patients after total knee arthroplasty (TKA). Inflammation is part of osteoarthritis' pathophysiology, and surgery induces a marked inflammatory response. We therefore wanted to explore the role of inflammation in long-term recovery after TKA, and thus conducted this secondary analysis of our randomized controlled trial (RCT) of physical rehabilitation ± progressive strength training (PST). We aimed to investigate whether (1) inflammation is associated with functional performance, knee-extension strength, and knee pain before TKA; (2) PST affects inflammation, and the inflammatory state over time; (3) baseline or surgery-induced inflammation modifies the effect of rehabilitation ± PST on change in 6-min walk test (Δ6MWT); and (4) baseline or surgery-induced inflammation is associated with Δ6MWT following TKA...
March 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28323136/self-reported-knee-pain-and-disability-among-healthy-individuals-reference-data-and-factors-associated-with-the-knee-injury-and-osteoarthritis-outcome-score-koos-and-koos-child
#16
J N Baldwin, M J McKay, C E Hiller, N Moloney, E J Nightingale, J Burns
OBJECTIVE: To develop normative reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child, as well as investigate socio-demographic, psychological and physical factors associated with knee pain and disability among healthy adults. METHOD: The KOOS or KOOS-Child (each containing five subscales) was administered to participants aged 8-101 years within the 1000 Norms Project, an observational study of 1000 self-reported healthy individuals...
March 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28302583/is-having-oa-an-independent-risk-factor-for-cardiovascular-events
#17
EDITORIAL
S M A Bierma-Zeinstra, T A Hoeven, J H Waarsing
No abstract text is available yet for this article.
March 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28300652/increased-risk-of-stroke-in-patients-with-osteoarthritis-a-population-based-cohort-study
#18
P-S Hsu, H-H Lin, C-R Li, W-S Chung
OBJECTIVES: Osteoarthritis (OA) is related to carotid atherosclerosis. Few studies have investigated the incidence of cerebrovascular diseases in patients with OA. Therefore, we conducted a population-based cohort study to determine the incidence and risk of stroke in patients with OA. METHODS: We used data from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000) to investigate the incidence of stroke in 43,635 patients with OA newly diagnosed between 2002 and 2003...
March 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28285000/reinforcement-of-articular-cartilage-with-a-tissue-interpenetrating-polymer-network-reduces-friction-and-modulates-interstitial-fluid-load-support
#19
B G Cooper, T Lawson, B D Snyder, M W Grinstaff
OBJECTIVE: Osteoarthritis (OA) is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support (IFLS) during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ synthesis of an interpenetrating polymer network (IPN) designed to mimic glycosaminoglycans (GAGs) depleted during OA. METHODS: Cylindrical osteochondral explants containing various interpenetrating polymer concentrations were subjected to a torsional friction test under unconfined creep compression...
March 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28285001/associations-between-changes-in-knee-pain-location-and-clinical-symptoms-in-people-with-medial-knee-osteoarthritis-using-footwear-for-self-management-an-exploratory-study
#20
A Van Ginckel, K L Bennell, P K Campbell, J Kasza, T V Wrigley, D J Hunter, R S Hinman
OBJECTIVE: To examine whether change in pain location is associated with clinically-relevant improvements in walking pain severity and physical dysfunction in people with medial tibiofemoral osteoarthritis (OA) using footwear for self-management. DESIGN: We analysed a sub-set of 91 participants pooled from both arms of a 6-month randomised controlled trial of footwear for knee OA. The Photographic Knee Pain Map was self-administered to generate changes in the number of painful zones ('unchanged', 'increased', 'decreased') and anatomical patterns of pain ('unchanged', 'no longer diffuse', 'becoming diffuse', 'other pattern changes')...
March 8, 2017: Osteoarthritis and Cartilage
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