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Osteoarthritis and Cartilage

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https://www.readbyqxmd.com/read/28823647/sprifermin-rhfgf18-enables-proliferation-of-chondrocytes-producing-a-hyaline-cartilage-matrix
#1
A Gigout, H Guehring, D Froemel, A Meurer, C Ladel, D Reker, A C Bay-Jensen, M A Karsdal, S Lindemann
OBJECTIVE: FGF18 has been shown to increase cartilage volume when injected intra-articularly in animal models of osteoarthritis (OA) and in patients with knee OA (during clinical development of the recombinant human FGF18, sprifermin). However, the exact nature of this effect is still unknown. In this study, we aimed to investigate the effects of sprifermin at the cellular level. DESIGN: A combination of different chondrocyte culture systems was used and the effects of sprifermin on proliferation, the phenotype and matrix production were evaluated...
August 17, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28823646/lentiviral-vector-mediated-shrnas-targeting-a-functional-isoform-of-the-leptin-receptor-ob-rb-inhibit-cartilage-degeneration-in-a-rat-model-of-osteoarthritis
#2
S L Deng, J Zhu, Q Huang, W L Fu, Q Li, G Chen, X Tang, J Li
OBJECTIVE: To downregulate the expression of leptin receptor functional isoform (Ob-Rb) on chondrocytes using lentiviral vector-mediated short-hairpin RNA (LV-shRNA) and to determine its effects on cartilage degeneration. METHOD: In vitro, quantitative real-time polymerase chain reaction and western blotting were performed to select an optimal Ob-Rb LV-shRNA (LV-shRNA3) and to determine its effects on nine OA-related mediators in cultured rat chondrocytes. In vivo, an OA model was surgically induced in the right knees of rats, and LV-shRNA3, lentiviral vector-mediated non-targeting control sequence (LV-NTC) or phosphate buffered saline was injected into the joints...
August 17, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28818737/genome-wide-dna-methylation-profiling-of-articular-cartilage-reveals-significant-epigenetic-alterations-in-kashin-beck-disease-and-osteoarthritis
#3
Wenyu Wang, Yan Yu, Jingcan Hao, Yan Wen, Jing Han, Weikun Hou, Ruiyu Liu, Bo Zhao, Awen He, Ping Li, Qianrui Fan, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo, Feng Zhang
OBJECTIVE: To determine genome-wide DNA methylation profiles of knee cartilage from patients with Kashin-Beck disease (KBD) and osteoarthritis (OA). METHOD: Knee cartilage was collected from 14 grade III KBD patients, 5 primary OA patients and 13 healthy subjects. The genome-wide methylation profiles of 5 KBD cartilage, 5 OA cartilage and 5 normal cartilage were determined by Illumina HumanMethylation450 array. Illumina Methylation Analyzer package was employed for identifying differentially methylated CpG sites...
August 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28803878/comments-on-effects-of-high-intensity-resistance-aquatic-training-on-body-composition-and-walking-speed-in-women-with-mild-knee-osteoarthritis-a-4-month-rct-with-12-month-follow-up
#4
LETTER
H A de Ruiter, B van Gorp, J F A Eijkenboom
No abstract text is available yet for this article.
August 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28802851/does-hydroxyapatite-coating-of-uncemented-cups-improve-long-term-survival-an-analysis-of-28-605-primary-total-hip-arthroplasty-procedures-from-the-nordic-arthroplasty-register-association-nara
#5
Stergios Lazarinis, Keijo T Mäkelä, Antti Eskelinen, Leif Havelin, Geir Hallan, Søren Overgaard, Alma B Pedersen, Johan Kärrholm, Nils P Hailer
OBJECTIVE: It is unclear whether hydroxyapatite (HA) coating of uncemented cups used in primary total hip arthroplasty (THA) improves bone ingrowth and reduces the risk of aseptic loosening. We therefore investigated survival of different uncemented cups that were available with or without HA coating. METHOD: We investigated three different cup types used with or without HA coating registered in the Nordic Arthroplasty Register Association (NARA) database that were inserted due to osteoarthritis (n=28,605)...
August 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801210/the-longitudinal-relationship-between-hand-hip-and-knee-osteoarthritis-and-cardiovascular-events-a-population-based-cohort-study
#6
T Kendzerska, P Jüni, L K King, R Croxford, I Stanaitis, G A Hawker
OBJECTIVE: In this population-based cohort study, we examined the association between the presence of symptomatic osteoarthritis (OA) and risk for cardiovascular (CV) events. METHOD: A cohort aged ≥55 years recruited from 1996 to 98 was followed through provincial health administrative data to 2014. Demographics, joint complaints and functional limitations were collected. Hip, knee and hand OA were defined using a validated definition. Using Cox-regressions, the relationship between OA and a composite CV outcome (myocardial infarction (MI), stroke, angina, heart failure, revascularization) was assessed controlling for age, body mass index (BMI), sex, pre-existing metabolic factors, comorbidities, income status, primary care exposure and functional limitations...
August 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801213/response-to-the-comments-on-effects-of-high-intensity-aquatic-resistance-training-on-body-composition-and-walking-speed-in-women-with-mild-knee-osteoarthritis-a-4-month-rct-with-12-month-follow-up
#7
LETTER
B Waller, M Munukka, U M Kujala, A O Heinonen
No abstract text is available yet for this article.
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801212/intraoperative-validation-of-quantitative-t2-mapping-in-patients-with-articular-cartilage-lesions-of-the-knee
#8
S Soellner, A Goldmann, D Muelheims, G H Welsch, M Pachowsky
OBJECTIVE: The aim of this study was to compare T2 relaxation times of knee cartilage with intraoperative results for the assessment of early osteoarthritis (OA) and to define T2 values for the differentiation between healthy and degenerated cartilage. DESIGN: Twenty-one patients with cartilage lesions or moderate OA were examined using 3T magnetic resonance imaging (MRI). In this prospective study, a total of 882 regions of interest (ROIs) were examined by a sagittal, multi-echo, spin-echo T2 sequence and a morphological high-resolution three-dimensional, fat-saturated proton-density space sequence...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801211/parkin-clearance-of-dysfunctional-mitochondria-regulates-ros-levels-and-increases-survival-of-human-chondrocytes
#9
M Y Ansari, N M Khan, I Ahmad, T M Haqqi
OBJECTIVE: Mitochondrial dysfunction, oxidative stress and chondrocyte death are important contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we determined the expression and role of Parkin in the clearance of damaged/dysfunctional mitochondria, regulation of reactive oxygen species (ROS) levels and chondrocyte survival under pathological conditions. METHODS: Human chondrocytes were from the unaffected area of knee OA cartilage (n = 12) and were stimulated with IL-1β to mimic pathological conditions...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801209/compromised-autophagy-precedes-meniscus-degeneration-and-cartilage-damage-in-mice
#10
J K Meckes, B Caramés, M Olmer, W B Kiosses, S P Grogan, M K Lotz, D D D'Lima
OBJECTIVE: Autophagy is a cellular homeostasis mechanism that facilitates normal cell function and survival. Objectives of this study were to determine associations between autophagic responses with meniscus injury, joint aging, and osteoarthritis (OA), and to establish the temporal relationship with structural changes in menisci and cartilage. METHODS: Constitutive activation of autophagy during aging was measured in GFP-LC3 transgenic reporter mice between 6 and 30 months...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28801208/projected-increase-in-total-knee-arthroplasty-in-the-united-states-an-alternative-projection-model
#11
M C S Inacio, E W Paxton, S E Graves, R S Namba, S Nemes
OBJECTIVE: The purpose of our study was to estimate the future incidence rate (IR) and volume of primary total knee arthroplasty (TKA) in the United States from 2015 to 2050 using a conservative projection model that assumes a maximum IR of procedures. Furthermore, our study compared these projections to a model assuming exponential growth, as done in previous studies, for illustrative purposes. METHODS: A population based epidemiological study was conducted using data from US National Inpatient Sample (NIS) and Census Bureau...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28778815/fourteen-days-of-etoricoxib-60%C3%A2-mg-improves-pain-hyperalgesia-and-physical-function-in-individuals-with-knee-osteoarthritis-a-randomized-controlled-trial
#12
P Moss, H A E Benson, R Will, A Wright
OBJECTIVE: Mounting evidence points to the heterogeneity of osteoarthritis (OA) pain, increasing the need for more comprehensive assessment of the efficacy of standard interventions. This study investigated whether 14 days of the selective Cox-2 inhibitor etoricoxib (60 mg/day) would modify self-report of pain intensity and quality, and physical measures of hyperalgesia and function in individuals with knee OA. DESIGN: This double-blind placebo-controlled trial included 80 community-recruited volunteers with painful knee OA (≥3/10 VAS), randomly allocated to Active or Placebo groups...
August 2, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28760350/an-approach-towards-accountability-suggestions-for-increased-reproducibility-in-surgical-destabilization-of-medial-meniscus-dmm-models
#13
EDITORIAL
A Ratneswaran, F Beier
No abstract text is available yet for this article.
July 29, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28757188/a-sex-specific-association-between-incident-radiographic-osteoarthritis-of-hip-or-knee-and-incident-peripheral-arterial-calcifications-8-year-prospective-data-from-cohort-hip-and-cohort-knee-check
#14
W P Gielis, P M J Welsing, W E van Spil, J Runhaar, H Weinans, P A de Jong
OBJECTIVES: There is sparse evidence for a relationship between cardiovascular disease (CVD) and osteoarthritis (OA). We investigated the association between incidence of arterial calcifications and incidence of radiographic knee and/or hip OA. DESIGN: We used baseline and 8-year follow-up data of Cohort Hip and Cohort Knee (CHECK). Knees and hips were either Kellgren-Lawrence (KL) grade 0 or 1 at baseline. Arterial calcifications were scored on hip and knee radiographs using a four-grade scale...
July 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28757187/gout-and-risk-of-knee-replacement-for-severe-knee-osteoarthritis-in-the-singapore-chinese-health-study
#15
G G Teng, Y Y Leung, L-W Ang, J-M Yuan, W-P Koh
OBJECTIVE: While cross-sectional and retrospective case-control studies suggest that gout is associated with knee osteoarthritis (KOA), no prospective study has evaluated the risk of total knee replacement (TKR) for KOA in association with gout. We prospectively evaluated the association between gout and the risk of TKR due to severe KOA. DESIGN: We used data from the Singapore Chinese Health Study (SCHS), a prospective cohort with 63,257 Chinese adults aged 45-74 years at recruitment (1993-1998)...
July 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28756279/association-between-statin-use-and-consultation-or-surgery-for-osteoarthritis-of-the-hip-or-knee-a-pooled-analysis-of-four-cohort-studies
#16
K Michaëlsson, L S Lohmander, A Turkiewicz, A Wolk, P Nilsson, M Englund
OBJECTIVE: Experimental findings and previous observational data have suggested lower risk of osteoarthritis (OA) with statin use but results are inconsistent. Large-scale studies with a clinically important outcome are needed. Thus, we aimed to determine whether statin use is associated with a reduced risk of developing clinically-defined hip or knee OA. DESIGN: Pooled analysis based on time-to-event analysis of four population-based large cohorts, encompassing in total 132,607 persons aged 57-91 years resident in southern and central Sweden...
July 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28756278/effects-of-dietary-weight-loss-with-and-without-exercise-on-interstitial-matrix-turnover-and-tissue-inflammation-biomarkers-in-adults-with-knee-osteoarthritis-the-intensive-diet-and-exercise-for-arthritis-trial-idea
#17
R F Loeser, D P Beavers, A C Bay-Jensen, M A Karsdal, B J Nicklas, A Guermazi, D J Hunter, S P Messier
OBJECTIVE: To examine the effects of dietary weight loss, with and without exercise, on selected soluble biomarkers in overweight and obese older adults with symptomatic knee osteoarthritis (OA). DESIGN: Blood samples were analyzed from 429 participants in the Intensive Diet and Exercise for Arthritis (IDEA) trial randomized to either an 18 month exercise control group (E), weight loss diet (D), or D + E. C1M, C2M, C3M and CRPM biomarkers and interleukin-6 (IL-6) were quantitated using ELISAs...
July 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28743608/quantitative-regional-and-sub-regional-analysis-of-femoral-and-tibial-subchondral-bone-mineral-density-sbmd-using-computed-tomography-ct-comparison-of-non-osteoarthritic-oa-and-severe-osteoarthritic-knees
#18
P Omoumi, H Babel, B M Jolles, J Favre
OBJECTIVE: This study aimed to compare subchondral bone mineral density (sBMD) between non-radiographic osteoarthritic (OA) and medial femorotibial OA knees, using computed tomography (CT). DESIGN: CT exams from 16 non-radiographic OA (KL grade < 2) and 16 severe medial OA (KL grade ≥ 3) knees (average age of 61.7 ± 3 and 62.2 ± 5 years old respectively, 50% male in each group), were retrospectively analyzed. CT exams were segmented and 3D maps of subchondral BMD (sBMD) based on the CT number in the most superficial 3 mm of femoral and tibial subchondral bone were computed...
July 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28736247/interleukin-1%C3%AE-affects-the-phospholipid-biosynthesis-of-fibroblast-like-synoviocytes-from-human-osteoarthritic-knee-joints
#19
K D Sluzalska, G Liebisch, G Lochnit, B Ishaque, H Hackstein, G Schmitz, M Rickert, J Steinmeyer
OBJECTIVE: Phospholipids (PLs), together with hyaluronan and lubricin, are involved in boundary lubrication within human articular joints. Levels of lubricants in synovial fluid (SF) have been found to be associated with the health status of the joint. However, the biosynthesis and release of PLs within human joints remains poorly understood. This study contributes to our understanding of the effects of cytokines on the biosynthesis of PLs using cultured fibroblast-like synoviocytes (FLS) from human osteoarthritic knee joints...
July 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#20
M H van den Bosch, A B Blom, V Kram, A Maeda, S Sikka, Y Gabet, T M Kilts, W B van den Berg, P L van Lent, P M van der Kraan, M F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis (OA). Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental OA in wild type (WT) and Wisp1(-/-) mice. METHODS: WT and Wisp1(-/-) mice were aged or experimental OA was induced with intraarticular collagenase injection, destabilization of the medial meniscus (DMM) or anterior cruciate ligament transection (ACLT)...
July 19, 2017: Osteoarthritis and Cartilage
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