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Osteoarthritis and Cartilage

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https://www.readbyqxmd.com/read/27923602/patient-specific-chondrolabral-contact-mechanics-in-patients-with-acetabular-dysplasia-following-treatment-with-peri-acetabular-osteotomy
#1
Christine L Abraham, Spencer J Knight, Christopher L Peters, Jeffrey A Weiss, Andrew E Anderson
OBJECTIVE: Using a validated, patient-specific finite element (FE) modeling protocol, we evaluated cartilage and labrum (i.e. chondrolabral) mechanics before and after peri-acetabular osteotomy (PAO) to provide insight into the ability of this procedure to improve mechanics in dysplastic hips. DESIGN: Five patients with acetabular dysplasia were recruited in this case-controlled, prospective study. Models, which included anatomy for bone, cartilage, and labrum, were generated from computed tomography arthrography scans acquired before and after PAO...
December 3, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27919783/the-potential-of-induced-pluripotent-stem-cells-as-a-tool-to-study-skeletal-dysplasias-and-cartilage-related-pathologic-conditions
#2
REVIEW
Huan Liu, Lei Yang, Fang Fang Yu, Sen Wang, Cuiyan Wu, Chengjuan Qu, Xiong Guo, Mikko J Lammi
The development of induced pluripotent stem cells (iPSCs) technology has opened up new horizons for development of new research tools especially for skeletal dysplasias, which often lack human disease models. Regenerative medicine and tissue engineering could be the next areas to benefit from refinement of iPSC methods to repair focal cartilage defects, while applications for osteoarthritis (OA) and drug screening have evolved rather slowly. Although the advances in iPSC research of skeletal dysplasias and repair of focal cartilage lesions are not directly relevant to OA, they can be considered to pave the way to future prospects and solutions to OA research, too...
December 2, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27916560/thinning-of-articular-cartilage-after-joint-unloading-or-immobilization-an-experimental-investigation-of-the-pathogenesis-in-mice
#3
Masato Nomura, Naoyoshi Sakitani, Hiroyuki Iwasawa, Yuta Kohara, Shoko Takano, Yoshio Wakimoto, Hiroshi Kuroki, Hideki Moriyama
OBJECTIVE: Moderate mechanical stress generated by normal joint loading and movement is essential for the maintenance of healthy articular cartilage. However, the effects of reduced loading caused by the absence of weight bearing or joint motion on articular cartilage and subchondral bone is still poorly understood. We aimed to characterize morphological and metabolic responses of articular cartilage and subchondral bone to decreased mechanical stress in vivo. METHODS: Mice were subjected to periods of hindlimb unloading by tail suspension or external fixation of the knee joints...
December 1, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27914878/hydroxytyrosol-modulates-the-levels-of-microrna-9-and-its-target-sirtuin-1-thereby-counteracting-oxidative-stress-induced-chondrocyte-death
#4
Stefania D'Adamo, Silvia Cetrullo, Serena Guidotti, Rosa Maria Borzì, Flavio Flamigni
OBJECTIVE: Nutraceutical compounds, such as hydroxytyrosol (HT), have been found to exert protective effects in osteoarthritis (OA) by affecting a variety of key molecular and cellular processes in chondrocytes. However, to our knowledge, no relationship has been reported between nutraceuticals and microRNA (miR) network in OA models. Here, we identified a miR that is implicated in hydroxytyrosol (HT)-mediated chondroprotection following oxidative stress condition by targeting sirtuin-1 (SIRT-1)...
November 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27914877/transcultural-adaptation-and-validation-of-the-chinese-version-of-the-intermittent-and-constant-osteoarthritis-pain-icoap-measure-in-patients-with-knee-osteoarthritis
#5
Chen Zhang, Denghui Liu, Yulan Qu, Zhenyu Jia, Wei Wang, Jia Li, Weidong Xu
OBJECTIVE: This study aimed to translate and adapt the intermittent and constant osteoarthritis pain (ICOAP) measure into the Chinese language (ICOAP-C), and to study its psychometric properties in patients with knee osteoarthritis (OA). DESIGN: The ICOAP was translated and cognitively pretested following internationally recommended guidelines. The psychometric properties including the reliability, validity and responsiveness were evaluated. The reliability, including the internal consistency and the test-retest reliability, was then evaluated in 108 outpatients with knee OA...
November 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27903450/low-energy-impact-of-human-cartilage-predictors-for-microcracking-the-network-of-collagen
#6
B Kaleem, F Maier, H Drissi, D M Pierce
OBJECTIVE: We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm(3) would suffice. DESIGN: We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s(2)) using healthy cartilage specimens from six male donors (30.2 ± 8.8 yrs old). Before and after impact we acquired, imaging the second harmonic generation (SHG), ten images from each specimen (50 μm depth, 5 μm step size), resulting in 2160 images...
November 27, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27903449/sex-differences-in-the-estrogen-dependent-regulation-of-temporomandibular-joint-remodeling-in-altered-loading
#7
Jennifer L Robinson, Katelyn Cass, Ross Aronson, Thomas Choi, Manshan Xu, Ryan Buttenbaum, Hicham Drissi, Helen H Lu, Jing Chen, Sunil Wadhwa
OBJECTIVE: Temporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role of estrogen in the disease etiology. Previously, we determined that decreased occlusal loading (DOL) inhibited collagen type II (Col2) expression in the mandibular condylar cartilage (MCC) of female wild-type (WT) mice whereas no change was observed in males. This decrease in chondrogenesis was abolished by estrogen receptor beta (ERβ) deficiency in females. Therefore, the goal of this study was to examine the role of estradiol - ERβ signaling in mediating DOL effects in male mice to further decipher sex differences...
November 26, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27894935/brief-report-stage-specific-differences-in-secretory-profile-of-mesenchymal-stromal-cells-mscs-subjected-to-early-vs-late-stage-oa-synovial-fluid
#8
Alejandro Gómez-Aristizábal, Anirudh Sharma, Mohsen A Bakooshli, Mohit Kapoor, Penney M Gilbert, Sowmya Viswanathan, Rajiv Gandhi
OBJECTIVE: Although, mesenchymal stromal cells (MSCs) are being clinically investigated for their use in osteoarthritis (OA), it is unclear whether their postulated therapeutic properties are equally effective in the early- and late-stages of OA. In this study we investigated MSC cytokine secretion post-exposure to synovial fluid (SF), obtained from early-vs. late-stage knee OA patients to justify a potential patient stratification strategy to maximize MSC-mediated treatment effects. METHOD: Subjects were recruited and categorized into early- [Kellgren-Lawrence (KL) grade I/II, n = 12] and late-stage (KL-III/IV, n = 12) knee OA groups...
November 25, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27884645/dysregulated-circadian-rhythm-pathway-in-human-osteoarthritis-nr1d1-and-bmal1-suppression-alters-tgf-%C3%AE-signaling-in-chondrocytes
#9
R Akagi, Y Akatsu, K M Fisch, O Alvarez-Garcia, T Teramura, Y Muramatsu, M Saito, T Sasho, A I Su, M K Lotz
OBJECTIVES: Circadian rhythm (CR) was identified by RNA sequencing as the most dysregulated pathway in human osteoarthritis (OA) in articular cartilage. This study examined circadian rhythmicity in cultured chondrocytes and the role of the CR genes NR1D1 and BMAL1 in regulating chondrocyte functions. METHODS: RNA was extracted from normal and OA-affected human knee cartilage (n = 14 each). Expression levels of NR1D1 and BMAL1 mRNA and protein were assessed by quantitative PCR and immunohistochemistry...
November 22, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27884646/microrna-92a-3p-regulates-the-expression-of-cartilage-specific-genes-by-directly-targeting-histone-deacetylase-2-in-chondrogenesis-and-degradation
#10
G Mao, Z Zhang, Z Huang, W Chen, G Huang, F Meng, Z Zhang, Y Kang
OBJECTIVE: Increased activity of histone deacetylase 2 (HDAC2) has been found in patients with osteoarthritis (OA) and cartilage matrix degradation and has been shown to mediate the repression of cartilage-specific gene expression in human chondrocytes. We aimed to determine whether microRNA-92a-3p (miR-92a-3p) regulates cartilage-specific gene expression via targeted HDAC2 in chondrogenesis and degradation. METHODS: miR-92a-3p expression was assessed in vitro in a human mesenchymal stem cells (hMSCs) model of chondrogenesis and in normal and OA primary human chondrocytes (PHCs), and in normal and OA human cartilage by in situ hybridization...
November 21, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27865755/corrigendum-to-fc-gamma-receptors-are-not-involved-in%C3%A2-cartilage%C3%A2-damage-during-experimental-osteoarthritis-osteoarthritis%C3%A2-cartilage%C3%A2-23-2015-1221-1225
#11
M Stock, A Distler, J Distler, C Beyer, G Ruiz-Heiland, N Ipseiz, M Seeling, G Krönke, F Nimmerjahn, G Schett
No abstract text is available yet for this article.
November 16, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27856294/role-of-the-c-c-chemokine-receptor-2-in-a-murine-model-of-injury-induced-osteoarthritis
#12
L Longobardi, J D Temple, L Tagliafierro, H Willcockson, A Esposito, N D'Onofrio, E Stein, T Li, T J Myers, H Ozkan, M L Balestrieri, V Ulici, R F Loeser, A Spagnoli
OBJECTIVE: We previously found in our embryonic studies that proper regulation of the chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate development. In the present study, we examined the role of CCR2 in injury-induced-osteoarthritis (OA). METHOD: We used a murine model of injury-induced-OA (destabilization of medial meniscus, DMM), and systemically blocked CCR2 using a specific antagonist (RS504393) at different times during disease progression...
November 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27856293/substantial-rise-in-the-lifetime-risk-of-primary-total-knee-replacement-surgery-for-osteoarthritis-from-2003-to-2013-an-international-population-level-analysis
#13
I N Ackerman, M A Bohensky, R de Steiger, C A Brand, A Eskelinen, A M Fenstad, O Furnes, G Garellick, S E Graves, J Haapakoski, L I Havelin, K Mäkelä, F Mehnert, A Becic Pedersen, O Robertsson
OBJECTIVE: To estimate and compare the lifetime risk of total knee replacement surgery (TKR) for osteoarthritis (OA) between countries, and over time. METHOD: Data on primary TKR procedures performed for OA in 2003 and 2013 were extracted from national arthroplasty registries in Australia, Denmark, Finland, Norway and Sweden. Life tables and population data were also obtained for each country. Lifetime risk of TKR was calculated for 2003 and 2013 using registry, life table and population data...
November 14, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27851984/intra-articular-therapy-with-recombinant-human-gdf5-arrests-disease-progression-and-stimulates-cartilage-repair-in-the-rat-medial-meniscus-transection-mmt-model-of-osteoarthritis
#14
W R Parrish, B A Byers, D Su, J Geesin, U Herzberg, S Wadsworth, A Bendele, B Story
OBJECTIVE: Investigation of osteoarthritis (OA) risk alleles suggests that reduced levels of growth and differentiation factor-5 (GDF5) may be a precipitating factor in OA. We hypothesized that intra-articular recombinant human GDF5 (rhGDF5) supplementation to the OA joint may alter disease progression. METHODS: A rat medial meniscus transection (MMT) joint instability OA model was used. Animals received either one intra-articular injection, or two or three bi-weekly intra-articular injections of either 30 μg or 100 μg of rhGDF5 beginning on day 21 post surgery after structural pathology had been established...
November 13, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27840128/whole-body-vibration-of-mice-induces-articular-cartilage-degeneration-with-minimal-changes-in-subchondral-bone
#15
Matthew R McCann, Cynthia Yeung, Michael A Pest, Anusha Ratneswaran, Steven I Pollmann, David W Holdsworth, Frank Beier, S Jeffrey Dixon, Cheryle A Séguin
OBJECTIVE: Low-amplitude, high-frequency whole-body vibration (WBV) has been adopted for the treatment of musculoskeletal diseases including osteoarthritis; however, there is limited knowledge of the direct effects of vibration on joint tissues. Our recent studies revealed striking damage to the knee joint following exposure of mice to WBV. The current study examined the effects of WBV on specific compartments of the murine tibiofemoral joint over 8 weeks, including microarchitecture of the tibia, to understand the mechanisms associated with WBV-induced joint damage...
November 10, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27838383/cross-sectional-and-longitudinal-study-of-the-impact-of-posterior-meniscus-horn-lesions-on-adjacent-cartilage-composition-patient-reported-outcomes-and-gait-biomechanics-in-subjects-without-radiographic-osteoarthritis
#16
C Russell, V Pedoia, R B Souza, S Majumdar
OBJECTIVE: The aim of this study was to assess cross-sectional and longitudinal effects of meniscal lesions on adjacent cartilage T1ρ and T2 relaxation times, patient-reported outcomes and gait biomechanics. DESIGN: Thirty patients with no cartilage morphological defects reported by Whole Organ MRI Score (WORMS) magnetic resonance imaging (MRI) grading and no radiographic osteoarthritis (OA) (Kellgren--Lawrence (KL) ≤ 1) were selected, 15 with posterior meniscus horn lesions and 15 matched controls without meniscal lesions...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27836678/finite-element-analysis-of-mechanical-behavior-of-human-dysplastic-hip-joints-a-systematic-review
#17
REVIEW
B Vafaeian, D Zonoobi, M Mabee, A R Hareendranathan, M El-Rich, S Adeeb, J L Jaremko
Developmental dysplasia of the hip (DDH) is a common condition predisposing to osteoarthritis (OA). Especially since DDH is best identified and treated in infancy before bones ossify, there is surprisingly a near-complete absence of literature examining mechanical behavior of infant dysplastic hips. We sought to identify current practice in finite element modeling (FEM) of DDH, to inform future modeling of infant dysplastic hips. We performed multi-database systematic review using PRISMA criteria. Abstracts (n = 126) fulfilling inclusion criteria were screened for methodological quality, and results were analyzed and summarized for eligible articles (n = 12)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27836677/the-effect-of-instruction-in-analgesic-use-compared-with-neuromuscular-exercise-on-knee-joint-load-in-patients-with-knee-osteoarthritis-a-randomized-single-blind-controlled-trial
#18
A Holsgaard-Larsen, B Clausen, J Søndergaard, R Christensen, T P Andriacchi, E M Roos
OBJECTIVE: To investigate the effect of a neuro-muscular exercise (NEMEX) therapy program compared with instructions in optimized analgesics and anti-inflammatory drug use (PHARMA), on measures of knee-joint load in people with mild to moderate knee osteoarthritis (OA). We hypothesized that knee joint loading during walking would be reduced by NEMEX and potentially increased by PHARMA. DESIGN: Single-blind, RCT comparing NEMEX therapy twice a week with PHARMA. Participants with mild-to-moderate medial tibiofemoral knee OA were randomly allocated (1:1) to one of two 8-week treatments...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27836676/cross-sectional-and-longitudinal-associations-between-serum-inflammatory-cytokines-and-knee-bone-marrow-lesions-in-patients-with-knee-osteoarthritis
#19
Z Zhu, P Otahal, B Wang, X Jin, L L Laslett, A Wluka, B Antony, W Han, X Wang, T Winzenberg, F Cicuttini, G Jones, C Ding
OBJECTIVE: To describe cross-sectional and longitudinal associations between serum levels of interleukin (IL) - 6, IL-17A, IL-17F, IL-23 and knee bone marrow lesions (BMLs) in patients with knee osteoarthritis (OA). DESIGN: Patients (n = 192) with symptomatic knee OA (mean 63 years, range 50-79, female 53%) were assessed at baseline and after 24 months. At each time point, serum IL-6, IL-17A, IL-17F and IL-23 were measured using Bio-Plex(®) Multiplex Immunoassays with Luminex xMAP technology...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27836675/association-of-knee-pain-with-a-reduction-in-thigh-muscle-strength-a-cross-sectional-analysis-including-4553-osteoarthritis-initiative-participants
#20
A Ruhdorfer, W Wirth, F Eckstein
OBJECTIVE: To cross-sectionally determine the quantitative relationship of age-adjusted, sex-specific isometric knee extensor and flexor strength to patient-reported knee pain. METHODS: Difference of thigh muscle strength by age, and that of age-adjusted strength per unit increase on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain scale, was estimated from linear regression analysis of 4553 Osteoarthritis Initiative (OAI) participants (58% women)...
November 9, 2016: Osteoarthritis and Cartilage
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