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Osteoarthritis and Cartilage

S M A Bierma-Zeinstra, T A Hoeven, J H Waarsing
No abstract text is available yet for this article.
March 13, 2017: Osteoarthritis and Cartilage
Pi-Shan Hsu, Hsuan-Hung Lin, Chi-Rong Li, Wei-Sheng Chung
OBJECTIVES: Osteoarthritis (OA) is related to carotid atherosclerosis. Few studies have investigated the incidence of cerebrovascular diseases in patients with OA. Therefore, we conducted a population-based cohort study to determine the incidence and risk of stroke in patients with OA. METHODS: We used data from Taiwan's Longitudinal Health Insurance Database 2000 to investigate the incidence of stroke in 43 635 patients with OA newly diagnosed between 2002 and 2003...
March 11, 2017: Osteoarthritis and Cartilage
Ans Van Ginckel, Kim L Bennell, Penny K Campbell, Jessica Kasza, Tim V Wrigley, David J Hunter, Rana S Hinman
OBJECTIVE: To examine whether change in pain location is associated with clinically-relevant improvements in walking pain severity and physical dysfunction in people with medial tibiofemoral osteoarthritis (OA) using footwear for self-management. DESIGN: We analysed a sub-set of 91 participants pooled from both arms of a 6-month randomised controlled trial of footwear for knee OA. The Photographic Knee Pain Map was self-administered to generate changes in the number of painful zones ('unchanged', 'increased', 'decreased') and anatomical patterns of pain ('unchanged', 'no longer diffuse', 'becoming diffuse', 'other pattern changes')...
March 8, 2017: Osteoarthritis and Cartilage
Benjamin G Cooper, Taylor Lawson, Brian D Snyder, Mark W Grinstaff
OBJECTIVE: Osteoarthritis is associated with increased articular cartilage hydraulic permeability and decreased maintenance of high interstitial fluid load support during articulation, resulting in increased friction on the cartilage solid matrix. This study assesses frictional response following in situ synthesis of an interpenetrating polymer network designed to mimic glycosaminoglycans depleted during osteoarthritis. METHODS: Cylindrical osteochondral explants containing various interpenetrating polymer concentrations were subjected to a torsional friction test under unconfined creep compression...
March 8, 2017: Osteoarthritis and Cartilage
Minh-Dung Truong, Byung Hyune Choi, Young Jick Kim, Moon Suk Kim, Byoung-Hyun Min
OBJECTIVE: To investigate whether granulocyte macrophage-colony stimulating factor (GM-CSF) can be used to increase the number of mesenchymal stem cells (MSCs) in blood clots formed by microfracture arthroplasty (MFX) and whether it can improve the therapeutic outcome for cartilage repair. METHODS: Thirty-six New Zealand white rabbits were divided into four groups: (1) control, (2) GM-CSF, (3) MFX, and (4) GM-CSF+MFX. GM-CSF was administrated intravenously (IV) at 10μg/kg body weight 20min before the MFX surgery...
March 8, 2017: Osteoarthritis and Cartilage
Tristan Maerz, Mackenzie Fleischer, Michael D Newton, Abigail Davidson, Meagan Salisbury, Perry Altman, Michael D Kurdziel, Kyle Anderson, Asheesh Bedi, Kevin C Baker
OBJECTIVE: Little is known regarding acute local and systemic processes following anterior cruciate ligament (ACL) rupture. No study has elucidated whether bone marrow-derived mesenchymal stem cells (MSCs) are mobilized into circulation and recruited to the injured joint. METHODS: In part one, Lewis rats were randomized to noninvasive ACL rupture (Rupture) or non-injured (Control) (n=6/group). After 72 hours, whole blood MSC concentration was assessed using flow cytometry...
March 8, 2017: Osteoarthritis and Cartilage
X Wang, F Cicuttini, X Jin, A E Wluka, W Han, Z Zhu, L Blizzard, B Antony, T Winzenberg, G Jones, C Ding
OBJECTIVE: To develop a measure of knee joint effusion-synovitis volume and to examine the effect of vitamin D supplementation on effusion-synovitis in patients with knee osteoarthritis (OA) and low vitamin D levels over 24 months. METHOD: Symptomatic knee OA patients with a low 25-(OH)D level (12.5-60 nmol/l) were recruited for a multi-centre, randomised, placebo-controlled and double-blind trial. Participants (age 63 ± 7 years, 208 females) were allocated to either 50,000 IU monthly vitamin D3 (n = 209) or placebo (n = 204) for 24 months...
March 6, 2017: Osteoarthritis and Cartilage
Jing Han, Danyang Li, Chengjuan Qu, Dong Wang, Liyun Wang, Xiong Guo, Mikko J Lammi
OBJECTIVE: To investigate the expression of enzymes involved in chondroitin sulfate (CS) sulfation in the articular cartilage isolated from adult patients with osteoarthritis (OA) and Kashin-Beck disease (KBD), using normal adults as controls. METHODS: Articular cartilage samples were collected from normal, OA and KBD adults aged 38-60 years old, and divided into three groups with six individual subjects in each group. The morphology and pathology grading of knee joint cartilage was examined by Safranin O staining...
March 5, 2017: Osteoarthritis and Cartilage
B Waller, M Munukka, T Rantalainen, E Lammentausta, M T Nieminen, I Kiviranta, H Kautiainen, A Häkkinen, U M Kujala, A Heinonen
OBJECTIVE: To investigate the effects of 4-months' intensive aquatic resistance training on body composition and walking speed in post-menopausal women with mild knee osteoarthritis (OA), immediately after intervention and after 12-months follow-up. Additionally, influence of leisure time physical activity (LTPA) will be investigated. DESIGN: This randomised clinical trial assigned 87 volunteer postmenopausal women into two study arms. The intervention group (n = 43) participated in 48 supervised intensive aquatic resistance training sessions over 4-months while the control group (n = 44) maintained normal physical activity...
March 3, 2017: Osteoarthritis and Cartilage
H Iijima, T Aoyama, K Nishitani, H Ito, N Fukutani, T Isho, E Kaneda, H Kuroki, S Matsuda
OBJECTIVE: To examine the clinical impact of coexisting lateral osteoarthritis (OA) in knees with mild medial OA. DESIGN: In patients with Kellgren/Lawrence (K/L) grade 2 OA in the medial compartment (n = 100; age: 56-89 years; 80.0% female), anteroposterior knee radiography was used to assess the presence of lateral OA, using grading systems from the Osteoarthritis Research Society International (OARSI) atlas and the K/L classification. The Japanese Knee Osteoarthritis Measure (JKOM), knee range of motion (ROM), and performance-based functional measures (10 m walk, timed up and go and five repetition chair stand maneuvers) were evaluated...
March 3, 2017: Osteoarthritis and Cartilage
J P Eyles, D J Hunter, S Meneses, N Collins, F Dobson, B R Lucas, K Mills
OBJECTIVE: To make a recommendation on the "best" instrument to assess attitudes toward and/or capabilities regarding self-management of osteoarthritis (OA) based on available measurement property evidence. METHODS: Electronic searches were performed in MEDLINE, EMBASE, CINAHL and PsychINFO (inception to 27 December 2016). Two reviewers independently rated measurement properties using the Consensus-based Standards for the selection of Health Measurement Instruments (COSMIN) 4-point scale...
March 3, 2017: Osteoarthritis and Cartilage
H Tateuchi, Y Koyama, H Akiyama, K Goto, K So, Y Kuroda, N Ichihashi
OBJECTIVE: To investigate whether higher daily cumulative hip moment at baseline is associated with subsequent radiographic progression of hip osteoarthritis (OA) over 12 months. DESIGN: Fifty patients with secondary hip OA, excluding patients with end-stage hip OA, participated in this prospective cohort study. Joint space width (JSW) of the hip was measured at baseline and 12 months later. With radiographic progression of hip OA (>0.5 mm/year in JSW) as dependent variable (yes/no), univariable and multivariable logistic regression analyses were performed to assess the association between load-related parameters during gait (i...
February 21, 2017: Osteoarthritis and Cartilage
M C Papandony, L Chou, M Seneviwickrama, F M Cicuttini, K Lasserre, A J Teichtahl, Y Wang, A M Briggs, A E Wluka
OBJECTIVE: To identify and synthesise evidence regarding patients' perceived health service needs related to osteoarthritis (OA). DESIGN: A comprehensive systematic scoping review of MEDLINE, PsycINFO, EMBASE and CINAHL (1990-2016) was performed to capture information regarding patient perceived health service needs related to OA. Risk of bias and quality of included articles were assessed. Relevant data were extracted and collated to provide a systematic review of the existing literature...
February 21, 2017: Osteoarthritis and Cartilage
C Sanchez, A-C Bay-Jensen, T Pap, M Dvir-Ginzberg, H Quasnichka, R Barrett-Jolley, A Mobasheri, Y Henrotin
The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanisms by which articular cartilage maintains its integrity throughout our lifetime is not fully understood, however there are numerous regulatory pathways known to govern ECM turnover in response to mechanical stimuli...
February 20, 2017: Osteoarthritis and Cartilage
L M Thoma, M P McNally, A M Chaudhari, T M Best, D C Flanigan, R A Siston, L C Schmitt
OBJECTIVE: To determine compartment-specific loading patterns during gait, quantified as joint reaction forces (JRF), of individuals with knee articular cartilage defects (ACD) compared to healthy controls (HC). METHODS: Individuals with ACDs and HC participated. Individuals with ACDs were divided into groups according to ACD location: PF (only a patellofemoral ACD), TF (only a tibiofemoral ACD), and MIX (both PF and TF ACDs). Participants underwent three-dimensional gait analysis at self-selected speed...
February 20, 2017: Osteoarthritis and Cartilage
A G H Mierzwa, J F Campos, M F Jesus, H B Nader, M Lazaretti-Castro, R D Reginato
OBJECTIVE: To investigate the effects of different strontium ranelate (SrR) doses alone or in combination with low-intensity and high-frequency mechanical vibration (MV) on articular cartilage in ovariectomized rats. DESIGN: Fifty 6-month-old female Wistar rats underwent ovariectomy (OVX) and after 3 months were divided into: control group (Control); SrR 300 mg/kg/day (SrR300); SrR 625 mg/kg/day (SrR625); MV; SrR 625 mg/kg/day plus MV (SrR625 + MV). The vehicle and the SrR were administered by gavage 7 days/week and vibration (0...
February 20, 2017: Osteoarthritis and Cartilage
C Thomas Appleton
No abstract text is available yet for this article.
February 20, 2017: Osteoarthritis and Cartilage
J A Kopec, J Cibere, L C Li, C Zhang, M Barber, H Qian, H Wong, G Steininger, H Prlic, J Simatovic, C Ratzlaff, E C Sayre, J Ye, B B Forster, J M Esdaile
OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing (RDD). Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime...
February 20, 2017: Osteoarthritis and Cartilage
L Sharma, M Hochberg, M Nevitt, A Guermazi, F Roemer, M D Crema, C Eaton, R Jackson, K Kwoh, J Cauley, O Almagor, J S Chmiel
OBJECTIVE: Among high risk individuals, whether knee lesions in tissues involved in osteoarthritis (OA) can improve prediction of knee OA is unclear. We hypothesized that models predicting (1) incident osteophytes and (2) incident osteophytes and joint space narrowing can be improved by including symptoms or function, and further improved by lesion status. DESIGN: In Osteoarthritis Initiative (OAI) participants with normal knee X-rays, we assessed cartilage damage, bone marrow lesions (BMLs), and menisci...
February 14, 2017: Osteoarthritis and Cartilage
A J Teichtahl, F M Cicuttini, F Abram, Y Wang, J-P Pelletier, P Dodin, J Martel-Pelletier
OBJECTIVE: Whether meniscal extrusion and bone marrow lesions (BMLs) are independently associated with the risk of knee osteoarthritis (OA) is unknown. METHODS: Data was extracted from the Osteoarthritis Initiative (OAI) cohort. Participants were grouped according to the absence (Kellgren-Lawrence (KL) grade ≤ 1, n = 2120) or presence (KL ≥ 2, n = 2249) of radiographic OA (ROA). Baseline meniscal extrusion and tibial BMLs were assessed. Tibial plateau cartilage volume was assessed at baseline and 72 months, while radiographic disease was assessed at baseline and 48 months...
February 13, 2017: Osteoarthritis and Cartilage
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