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Osteoarthritis and Cartilage

Xia Wang, David J Hunter, Xingzhong Jin, Changhai Ding
Synovial abnormalities have been observed at multiple stages of osteoarthritis (OA). Increasing evidence suggests that it may play an important role in the OA pathological process. Many assessment systems using magnetic resonance imaging (MRI) and ultrasound have been established to detect synovial inflammation in OA. These have been used to inform the current investigation of OA disease phenotypes and progression and can be utilised in the future for clinical trials developing potential treatments. This narrative review aims to illustrate the importance of synovial tissue in OA and provide an overview of imaging assessments and possible therapies targeting synovial abnormalities...
December 7, 2017: Osteoarthritis and Cartilage
Elizaveta E Vaysbrot, Mikala C Osani, Mia-Cara Musetti, Timothy E McAlindon, Raveendhara R Bannuru
OBJECTIVE: To clarify the effects of bisphosphonates in knee osteoarthritis (OA) using an up-to-date meta-analysis of randomized controlled trials (RCTs). DESIGN: The protocol is registered in PROSPERO (CRD42017073449). We searched MEDLINE, EMBASE, Google Scholar, Web of Science, and Cochrane Database from inception until August 2017. We included only RCTs comparing any bisphosphonates vs. placebo in knee OA patients and reporting validated pain and function scales, radiographic progression, and adverse events outcomes...
December 5, 2017: Osteoarthritis and Cartilage
Johannes T H Nielen, Annelies Boonen, Pieter C Dagnelie, Bart J F van den Bemt, Pieter J Emans, Floris P J G Lafeber, Willem E van Spil, Frank de Vries, Paco M J Welsing
OBJECTIVE: On a population level, the incidence of knee prostheses (KP) has increased, but excess health care costs per patient, compared to matched controls without a KP, in the years surrounding these procedures and their determinants are largely unknown. We therefore aimed to provide estimates of age and sex-specific incidence of KPs, revision KPs, and prosthesis complications in patients with knee osteoarthritis (OA) and to determine excess health care costs in the years surrounding surgery compared with matched controls...
November 30, 2017: Osteoarthritis and Cartilage
Joan Calvet, Cristóbal Orellana, Néstor Albiñana Giménez, Antoni Berenguer-Llergo, Assumpta Caixàs, María García-Manrique, Carlos Galisteo Lencastre, Noemí Navarro, Marta Larrosa, Jordi Gratacós
OBJECTIVE: Adipokines have been reported to play a role in the development, progression and severity of knee osteoarthritis but the influence of the different adipokines are not well known. The aim of this study was to evaluate the association between different synovial fluid adipokines with pain and disability knee osteoarthritis patients. METHODS: Cross-sectional study with systematic inclusion of 115 symptomatic primary knee osteoarthritis female patients with ultrasound-confirmed joint effusion...
November 28, 2017: Osteoarthritis and Cartilage
B Duncan X Lascelles, Dorothy C Brown, William Maixner, Jeffrey S Mogil
OBJECTIVE: To outline the role that spontaneous osteoarthritis in companion animals can play in translational research and therapeutic pharmacological development. OUTLINE: Narrative review summarizing the opportunities and limitations of naturally occurring, spontaneous osteoarthritis as models of human osteoarthritis pain, with a focus on companion animal pets. The background leading to considering inserting spontaneous disease models in the translational paradigm is provided...
November 24, 2017: Osteoarthritis and Cartilage
Sven Nebelung, Björn Sondern, Holger Jahr, Markus Tingart, Matthias Knobe, Johannes Thüring, Christiane Kuhl, Daniel Truhn
OBJECTIVE: To define the physiological response to sequential loading and unloading in histologically intact human articular cartilage using serial T1ρ mapping, as T1ρ is considered to indicate the tissue's macromolecular content. METHOD: 18 macroscopically intact cartilage-bone samples were obtained from the central lateral femoral condyles of 18 patients undergoing total knee replacement. Serial T1ρ mapping was performed on a clinical 3.0-T MRI system using a modified prostate coil...
November 21, 2017: Osteoarthritis and Cartilage
P Behrendt, M Feldheim, A Preusse-Prange, J T Weitkamp, M Haake, D Eglin, B Rolauffs, J Fay, A Seekamp, A J Grodzinsky, B Kurz
OBJECTIVE: The application of adjunctive mediators in ACI techniques might be useful for improving the dedifferentiated chondrocyte phenotype, to support neocartilage formation and inhibit post-traumatic cartilage destruction. In this study we examined if (a) interleukin 10 treatment can cause chondrogenic phenotype stabilization and matrix preservation in mechanically injured cartilage and if (b) IL-10 can promote chondrogenesis in a clinically applied collagen scaffold for ACI treatment...
November 20, 2017: Osteoarthritis and Cartilage
R Pailhe, A Mounier, B Boisson, R C Rouchy, S Voros, E Chipon, I Boudry, M Medici, C Hughes, A Moreau-Gaudry
OBJECTIVE: The purpose of this study was to investigate the ability of full-field optical coherence tomography (FFOCT) to qualitatively and quantitatively evaluate cartilage degeneration using the qualitative evaluation of histology sections as the reference. DESIGN: 33 human knee cartilage samples of variable degeneration were included in the study. A closely matching histology and FFOCT image was acquired for each sample. The cartilage degeneration was qualitatively evaluated by assigning a grade to each histology and FFOCT image...
November 18, 2017: Osteoarthritis and Cartilage
Fredrik Persson, Aleksandra Turkiewicz, Dan Bergkvist, Paul Neuman, Martin Englund
OBJECTIVE: To compare consultation rate for knee osteoarthritis (OA) after meniscus repair, arthroscopic partial meniscectomy (APM), and in general population, respectively. METHOD: We identified patients aged 16-45 years having had meniscus surgery due to traumatic meniscus tear in 1998-2010 in southern Sweden by a healthcare register. Patients were followed from surgery until a diagnosis of knee OA, relocation, death, or December 31(st), 2015. We studied the consultation rate for knee OA compared to the general population...
November 13, 2017: Osteoarthritis and Cartilage
Aileen M Davis, Deborah Kennedy, Rosalind Wong, Susan Robarts, Søren T Skou, Rhona McGlasson, Linda C Li, Ewa Roos
OBJECTIVE: Adapt and evaluate the feasibility of implementing Good Life with osteoArthritis in Denmark (GLA:D(TM)) in Canada for people with mild to severe hip/knee osteoarthritis. METHODS: Patients triaged to non-surgical management participated in two education sessions and 12 supervised, neuromuscular exercise classes. We used the RE-AIM implementation framework evaluating outcomes of Reach, Effectiveness/Efficacy, Adoption, Implementation and Maintenance. Patients completed surveys pre-program and at 3 months follow-up...
November 13, 2017: Osteoarthritis and Cartilage
Jeffrey N Katz, Elena Losina
No abstract text is available yet for this article.
November 11, 2017: Osteoarthritis and Cartilage
Jan J Rongen, Gerjon Hannink
No abstract text is available yet for this article.
November 11, 2017: Osteoarthritis and Cartilage
I N Ackerman, E Zomer, J F-M Gilmartin-Thomas, D Liew
OBJECTIVE: To quantify the current national burden of opioids for osteoarthritis (OA) pain in Australia in terms of number of dispensed opioid prescriptions and associated costs, and to forecast the likely burden to the year 2030/31. DESIGN: Epidemiological modelling. METHODS: Published data were obtained on rates of opioid prescribing for people with OA and national OA prevalence projections. Trends in opioid dispensing from 2006 to 2016, and average costs for common opioid subtypes were obtained from the Pharmaceutical Benefits Scheme (PBS) and Medicare Australia Statistics...
November 9, 2017: Osteoarthritis and Cartilage
C-H Chou, D E Attarian, H-G Wisniewski, P A Band, V B Kraus
PURPOSE: To explore mechanisms underlying the association of TSG-6 with osteoarthritis (OA) progression. METHODS: TSG-6-mediated heavy chain (HC) transfer (TSG-6 activity) and its association with inflammatory mediators were quantified in knee OA (n = 25) synovial fluids (SFs). Paired intact and damaged cartilages from the same individuals (20 tibial and 12 meniscal) were analyzed by qRT-PCR and immunohistochemistry (IHC) for gene and protein expression of TSG-6 and components of Inter-alpha-Inhibitor (IαI) (necessary for TSG-6 activity), and for TSG-6 activity ± spiked in IαI...
November 9, 2017: Osteoarthritis and Cartilage
N M Brisson, P W Stratford, M R Maly
OBJECTIVE: Biomechanical factors are important treatment targets in knee osteoarthritis. The knee adduction (KAM) and flexion (KFM) moments, quadriceps strength and power, load frequency, and body mass index (BMI) all have the potential to affect knee articular cartilage integrity by modulating forces across the joint. To identify clinically meaningful change, however, these measurements must be reliable and sensitive to change. This study estimated relative and absolute test-retest reliabilities over long periods of biomechanical risk factors for knee osteoarthritis progression...
November 9, 2017: Osteoarthritis and Cartilage
D Loukov, S Karampatos, M R Maly, D M E Bowdish
OBJECTIVE: Monocytes contribute to synovitis and disease pathogenesis in osteoarthritis (OA). Low-grade inflammation occurs in OA and correlates with disease severity and progression. Since monocyte development and function is altered by systemic inflammation, we analyzed monocyte numbers and function between individuals with knee OA and healthy age- and sex-matched controls. DESIGN: We analyzed markers of soluble and cellular inflammation in peripheral blood of women with knee OA and compared them to healthy age- and sex-matched controls...
November 8, 2017: Osteoarthritis and Cartilage
K L Paterson, J Kasza, K L Bennell, T V Wrigley, B R Metcalf, P K Campbell, D J Hunter, R S Hinman
OBJECTIVE: To investigate moderators and biomechanical mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis (OA). METHODS: Exploratory analysis from 164 participants in a clinical trial comparing unloading (ASICS GEL-Melbourne OA) to conventional walking shoes. The primary outcome was 6-month change in knee pain (11-point numerical rating scale (NRS)). Moderators included baseline peak knee adduction moment (KAM), radiographic severity (Kellgren & Lawrence (KL) scale), body mass, foot posture, neuropathic pain and diffuse knee pain...
November 8, 2017: Osteoarthritis and Cartilage
D S Reece, T Thote, A S P Lin, N J Willett, R E Guldberg
OBJECTIVE: The objective of this study was to characterize early osteoarthritis (OA) development in cartilage and bone tissues in the rat medial meniscus transection (MMT) model using non-destructive equilibrium partitioning of an ionic contrast agent micro-computed tomography (EPIC-μCT) imaging. Cartilage fibrillation, one of the first physiological developments in OA, was quantified in the rat tibial plateau as three-dimensional (3D) cartilage surface roughness using a custom surface-rendering algorithm...
October 28, 2017: Osteoarthritis and Cartilage
F E Watt
OBJECTIVE: To summarise important findings from biomarker studies relevant to osteoarthritis (OA), published between April 2016 and March 2017; to consider these findings in the context of new discoveries and technologies, and clinical and scientific need in OA. DESIGN: Studies were selected by PubMed search, conducted between 01/04/2016 and 01/03/2017. MeSH terms [biomarker] AND [OA] were used; the search was restricted to Human, English language and Full Text Available publications, which yielded 50 eligible publications...
October 26, 2017: Osteoarthritis and Cartilage
A Holsgaard-Larsen, R Christensen, B Clausen, J Søndergaard, T P Andriacchi, E M Roos
OBJECTIVE: To test long-term effectiveness of neuromuscular exercise (NEMEX) with instructions in optimized pharmacological treatment (PHARMA) on activities of daily living (ADL) in patients with early knee osteoarthritis. DESIGN: 12-months follow-up from a randomized controlled trial. Participants with mild-to-moderate medial tibiofemoral knee osteoarthritis were randomly allocated to 8 weeks NEMEX or PHARMA. The primary outcome measure was the ADL-subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS)...
October 26, 2017: Osteoarthritis and Cartilage
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