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Osteoarthritis and Cartilage

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https://www.readbyqxmd.com/read/29454594/low-magnesium-intake-is-associated-with-increased-knee-pain-in-subjects-with-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#1
Anna Shmagel, Naoko Onizuka, Lisa Langsetmo, Tien Vo, Robert Foley, Kristine Ensrud, Peter Valen
OBJECTIVE: As magnesium mediates bone and muscle metabolism, inflammation, and pain signaling, we aimed to evaluate whether magnesium intake is associated with knee pain and function in radiographic knee osteoarthritis. METHODS: We investigated the associations between knee pain/function metrics and magnesium intake from food and supplements in 2548 Osteoarthritis Initiative cohort participants with prevalent radiographic knee OA (Kellgren-Lawrence score ≥2). Magnesium intake was assessed by Food Frequency Questionnaire at baseline...
February 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29438746/longitudinal-changes-in-mr-t1%C3%AF-t2-signal-of-meniscus-and-its-association-with-cartilage-t1p-t2-in-acl-injured-patients
#2
Joseph Knox, Valentina Pedoia, Amy Wang, Matthew Tanaka, Gabby B Joseph, Jan Neumann, Thomas M Link, Xiaojuan Li, C Benjamin Ma
OBJECTIVE: To evaluate the longitudinal changes in meniscal T1ρ/T2 signal post-reconstruction in patients with acute anterior cruciate ligament (ACL) injury and to investigate the association with T1ρ/T2 signal in articular knee cartilage. METHOD: In this prospective study, knees of 37 patients with ACL-injury and reconstruction in addition to 13 healthy controls were scanned using magnetic resonance imaging (MRI) T1ρ/T2 mapping. Quantitative analysis of the meniscus was performed in the anterior/posterior horns of lateral/medial meniscus fourteen sub-compartments of cartilage spanning the medial/lateral area of the tibia and femoral condyles...
February 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29428318/medial-and-lateral-laxity-in-knees-with-advanced-medial-osteoarthritis
#3
Yoshinori Ishii, Hideo Noguchi, Junko Sato, Hana Ishii, Koji Todoroki, Shin-Ichi Toyabe
OBJECTIVE: An increase in coronal laxity is recognized as a risk factor for progression of knee osteoarthritis (OA). The purpose of this study was to evaluate coronal laxity, which was defined as the angular motion from the neutral, unloaded (baseline) position to the loaded position, in patients with advanced medial knee OA. METHOD: Preoperative coronal laxity was assessed using radiographs in patients with medial knee OA undergoing total knee arthroplasty by applying a force of 150 N with an arthrometer...
February 8, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29427725/knee-extensor-strength-gains-mediate-symptom-improvement-in-knee-osteoarthritis-secondary-analysis-of-a-randomised-controlled-trial
#4
Michelle Hall, Rana S Hinman, Tim V Wrigley, Jessica Kasza, Boon-Whatt Lim, Kim L Bennell
OBJECTIVE: To determine if an increase in knee extensor strength mediates the effect of a 12-week knee extensor strength training program on pain and physical function improvement in people with knee osteoarthritis. DESIGN: Secondary analysis from a randomised controlled trial comparing the effects of a 12-week knee extensor strengthening exercise program to a control group with no intervention. METHODS: Data from participants with complete data (n=97) enrolled in a previous clinical trial were analysed...
February 7, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29427724/relation-of-meniscus-pathology-to-prevalence-and-worsening-of-patellofemoral-joint-osteoarthritis-the-multicenter-osteoarthritis-study
#5
Harvi F Hart, Kay M Crossley, David Felson, Mohamed Jarraya, Ali Guermazi, Frank Roemer, Beth Lewis, Jim Torner, Michael Nevitt, Joshua J Stefanik
OBJECTIVE: To determine the relationship of meniscal damage to magnetic resonance imaging (MRI) features of compartment-specific patellofemoral joint (PFJ) osteoarthritis (OA) at baseline and 2 years later. METHOD: Individuals from a prospective cohort of individuals aged 50-79 with or at risk of knee OA were included. At the 60-month and 84-month study visit, Whole-Organ MRI Score (WORMS) was used to assess meniscal tears and extrusions as well as cartilage damage and bone marrow lesions (BMLs) in the medial and lateral patella and trochlea...
February 7, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29427723/intra-articular-injection-of-mesenchymal-stem-cells-in-treating-knee-osteoarthritis-a-systematic-review-of-animal-studies
#6
Dan Xing, Joey Kwong, Ziyi Yang, Yunfei Hou, Wei Zhang, Bin Ma, Jianhao Lin
PURPOSE: Mesenchymal stem cells (MSCs) injection has emerged as a novel treatment for knee osteoarthritis (KOA) but with inconsistent results in the experimental studies. Thus, the purpose of the present study is to evaluate the preclinical animal studies of MSCs injection for KOA and to determine the evidence for a role for MSCs in further clinical trials. METHODS: A systematic search of KOA animal studies published through Aug 2017 was conducted using the PubMed, EMBASE and web of science...
February 7, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426013/celecoxib-mediated-reduction-of-prostanoid-release-in-hoffa-s-fat-pad-from-donors-with-cartilage-pathology-results-in-an-attenuated-inflammatory-phenotype
#7
Ufuk Tan Timur, Marjolein M J Caron, Yvonne M Bastiaansen-Jenniskens, Tim J M Welting, L W van Rhijn, Gerjo J V M van Osch, Pieter J Emans
OBJECTIVE: The Hoffa's fat pad (HFP) is an intra-articular adipose tissue which is situated under and behind the patella. It contains immune cells next to adipocytes and secretes inflammatory factors during osteoarthritis (OA). In this study, we compared the release profile of prostanoids, which are involved in inflammation, of HFP from OA patients versus patients with a focal cartilage defect without evidence for OA on MRI and investigated the prostanoid modulatory anti-inflammatory action of celecoxib on HFP...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426012/mri-ute-t2-profile-characteristics-correlate-to-walking-mechanics-and-patient-reported-outcomes-2-years-after-acl-reconstruction
#8
Ashley A Williams, Matthew R Titchenal, Thomas P Andriacchi, Constance R Chu
OBJECTIVE: Quantitative MRI Ultrashort echo time (UTE) T2* is sensitive to cartilage deep tissue matrix changes after anterior cruciate ligament reconstruction (ACLR). This study was performed to determine whether UTE-T2* profile analyses is a useful clinical metric for assessing cartilage matrix degeneration. This work tests the hypotheses that UTE-T2* depthwise rates of change (profile slopes) correlated with clinical outcome metrics of walking mechanics and patient reported outcomes (PRO) in patients 2 years after ACLR...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426011/the-knee-osteoarthritis-and-biomarkers
#9
EDITORIAL
Joshua M Farber
No abstract text is available yet for this article.
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426010/persisting-cam-deformity-is-associated-with-early-cartilage-degeneration-after-slipped-capital-femoral-epiphysis-11-year-follow-up-including-dgemric
#10
Jakob Örtegren, Pernilla Peterson, Jonas Svensson, Carl J Tiderius
OBJECTIVE: Slipped capital femoral epiphysis (SCFE) in adolescence is associated with increased risk of future osteoarthritis (OA). The purpose of this study was to study clinical and radiographic risk factors for early cartilage degeneration after SCFE. DESIGN: 22 patients (44 hips) (mean age 24 years, range 18-27) treated with in situ fixation (The Hansson hook-pin) for stable SCFE on average 11 years previously were investigated. Cartilage status was assessed with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC)...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426009/clinimetrics-of-ultrasound-pathologies-in-osteoarthritis-systematicliterature-review-and-meta-analysis
#11
REVIEW
Win Min Oo, James M Linklater, Matthew Daniel, Simo Saarakkala, Jonathan Samuels, Philip G Conaghan, Helen I Keen, Leticia A Deveza, David J Hunter
OBJECTIVE: The aims of this study were to systematically review clinimetrics of commonly assessed ultrasound pathologies in knee, hip and hand osteoarthritis (OA), and to conduct a meta-analysis for each clinimetric. METHODS: MEDLINE, EMBASE, and Cochrane Library databases were searched from their inceptions to September 2016. According to the OMERACT Instrument Selection Algorithm, data extraction focused on ultrasound technical features and performance metrics...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426008/colchicine-lack-of-effectiveness-in-symptom-and-inflammation-modification-in-knee-osteoarthritis-colkoa-a-randomized-controlled-trial
#12
Ying-Ying Leung, Benjamin Haaland, Janet L Huebner, Steven Bak-Siew Wong, Madeline Tjai, Chunyan Wang, Balram Chowbay, Julian Thumboo, Bibhas Chakraborty, Mann Hong Tan, Virginia B Kraus
OBJECTIVES: Uric acid may activate an innate immune response in osteoarthritis (OA), contributing to disease pathology and progression. We evaluated the effectiveness of colchicine on pain and function in symptomatic knee OA (KOA) and the underlying mechanism of action. METHODS: COLKOA was a double-blind, placebo-controlled, randomized trial comparing 16 weeks of treatment with 0.5 mg twice-daily oral colchicine to placebo for KOA. The primary endpoint was ≥30% improvement in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score at week 16...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426007/how-do-patients-trade-off-surgeon-choice-and-waiting-times-for-total-joint-replacement-a-discrete-choice-experiment
#13
Deborah A Marshall, Ken Deal, Barbara Conner-Spady, Eric Bohm, Gillian Hawker, Lynda Loucks, Karen V MacDonald, Tom Noseworthy
OBJECTIVE: Patients face significant waiting times for hip and knee total joint replacement (TJR) in publicly funded healthcare systems. We aimed to assess how surgeon selection and reputation affect patients' willingness to wait for TJR. DESIGN: We assessed patient preferences using a discrete choice experiment questionnaire with 12 choice scenarios administered to patients referred for TJR. Based on qualitative research, pre- and pilot-testing, we characterized each scenario by five attributes: surgeon reputation, surgeon selection, waiting time to surgeon visit (initial consultation), waiting time to surgery, and travel time to hospital...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426006/effectiveness-of-an-ayurveda-treatment-approach-in-knee-osteoarthritis-a-randomized-controlled-trial
#14
Christian S Kessler, Kartar S Dhiman, Abhimanyu Kumar, Thomas Ostermann, Shivenarain Gupta, Antonio Morandi, Martin Mittwede, Elmar Stapelfeldt, Michaela Spoo, Katja Icke, Andreas Michalsen, Claudia M Witt
OBJECTIVE: Ayurveda is commonly used in South Asia to treat knee osteoarthritis (OA). We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional conservative care in patients with knee OA. METHOD: According to American College of Rheumatology (ACR) criteria knee OA patients were included in a multicenter randomized, controlled, open-label trial and treated in 2 hospital clinics and 2 private outpatient clinics in Germany. Participants received either a multi-modal Ayurvedic treatment or multi-modal conventional care with 15 treatments over 12 weeks respectively...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29426005/harmonising-measures-of-knee-and-hip-osteoarthritis-in-population-based-cohort-studies-an-international-study
#15
K M Leyland, L S Gates, M Nevitt, D Felson, S M Bierma-Zeinstra, P G Conaghan, L Engebretsen, M Hochberg, D J Hunter, G Jones, J M Jordan, A Judge, L S Lohmander, E M Roos, M T Sanchez-Santos, N Yoshimura, J B J van Meurs, M E Batt, J Newton, C Cooper, N K Arden
OBJECTIVE: Population-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses. METHOD: International OA experts met to make recommendations on: 1) defining OA by x-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29408279/natural-history-of-pain-and-disability-among-african-americans-and-whites-with-or-at-risk-for-knee-osteoarthritis-a-longitudinal-study
#16
E R Vina, D Ran, E L Ashbeck, C K Kwoh
OBJECTIVE: Compare knee pain and disability between African Americans (AAs) and Whites (WHs), with or at risk of knee osteoarthritis (KOA), over 9 years, and evaluate racial disparities in KOA-related symptoms across socioeconomic and clinical characteristics. DESIGN: Osteoarthritis Initiative participants were evaluated annually over 9 years for pain and disability, assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and a numerical rating scale (NRS) for knee pain severity...
February 2, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29406252/osteoarthritis-cerebrovascular-dysfunction-and-the-common-denominator-of-inflammation-a-narrative-review
#17
REVIEW
B K Al-Khazraji, C T Appleton, F Beier, T B Birmingham, J K Shoemaker
OBJECTIVE: Population-based cohort studies suggest an association between osteoarthritis (OA) and cerebrovascular disease, yet the mechanisms underlying vascular comorbidities in OA remain unclear. The purpose of this narrative review is to discuss the literature examining inflammation in OA with a focus on physiological mechanisms, and whether overlapping mechanisms exist in cerebrovascular dysfunction. METHOD: A literature search was conducted in PubMed using combinations of search terms: osteoarthritis, cerebrovascular (disease/dysfunction/risk), cardiovascular (disease/dysfunction/risk), aging/ageing, inflammation, inflammatory mediators, cytokine, c-reactive protein, interleukin, advanced glycation end-products, metabolic syndrome, reactive oxidative species, cognitive impairment, (vascular-related) dementia, small cerebral vessel disease, endothelial function, blood-brain barrier, gender/sex, hypertension, peripheral vascular health, and physical activity...
January 31, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29391278/human-umbilical-cord-wharton-s-jelly-mesenchymal-stem-cells-combined-with-an-acellular-cartilage-extracellular-matrix-scaffold-improve-cartilage-repair-compared-with-microfracture-in-a-caprine-model
#18
Yu Zhang, Shuyun Liu, Weimin Guo, Mingjie Wang, Chunxiang Hao, Shuang Gao, Xueliang Zhang, Xu Li, Mingxue Chen, Xiaoguang Jing, Zehao Wang, Jiang Peng, Shibi Lu, Quanyi Guo
OBJECTIVE: As a novel and promising seed cell, human umbilical cord Wharton's jelly mesenchymal stem cells(hWJMSCs) are widely applied in tissue engineering. However, whether hWJMSCs can better repair and regenerate the articular cartilage in big animals than microfracture(MF, a predominant clinical treatment strategy for damaged cartilage) is unclear. Evaluation of the validity, and safety of hWJMSCs in a caprine model with a full-thickness femoral condyle articular cartilage defect, compared with MF is required...
January 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29391277/pain-and-functional-trajectories-in-symptomatic-knee-osteoarthritis-over-up-to-12-weeks-of-exercise-exposure
#19
Augustine C Lee, William F Harvey, Xingyi Han, Lori Lyn Price, Jeffrey B Driban, Raveendhara R Bannuru, Chenchen Wang
OBJECTIVE: Exercise is the recommended treatment for knee osteoarthritis (OA). However, heterogeneous patterns in treatment response are poorly understood. Our purpose was to identify pain and functional trajectories from exercise interventions in knee OA, and to determine their association with baseline factors. METHODS: Prospective cohort of 171 participants (mean age 61 years; BMI 32kg/m2, 71% female; 57% white) with symptomatic knee OA from a randomized trial comparing 12-week Tai Chi and Physical Therapy...
January 29, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29391276/molecular-influence-of-anterior-cruciate-ligament-tear-remnants-on-chondrocytes-a-biologic-connection-between-injury-and-osteoarthritis
#20
Nobuaki Chinzei, Robert H Brophy, Xin Duan, Lei Cai, Ryan M Nunley, Linda J Sandell, Muhammad Farooq Rai
OBJECTIVE: Anterior cruciate ligament (ACL) injury initiates a cascade of events often leading to osteoarthritis. ACL reconstruction does not alter the course of osteoarthritis, suggesting that heightened osteoarthritis risk is likely due to factors in addition to the joint instability. We showed that torn ACL remnants express periostin (POSTN) in the acute phase of injury. Considering that ACL injury predisposes to osteoarthritis and that POSTN is associated with cartilage metabolism, we hypothesize that ACL injury affects chondrocytes via POSTN...
January 29, 2018: Osteoarthritis and Cartilage
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