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Osteoarthritis and Cartilage

Victoria Brander, Nebojsa Skrepnik, Robert J Petrella, Guang-Liang Jiang, Beverly Accomando, Anna Vardanyan
OBJECTIVE: Hip osteoarthritis (OA) is difficult to treat. Steroid injections reduce pain with short duration. With widespread adoption of office-based, image-guided injections, hyaluronic acid is a potentially relevant therapy. In the largest clinical trial to-date, we compared safety/efficacy of a single, 6-mL image-guided injection of hylan G-F 20 to saline in painful hip OA. METHOD: 357 patients were enrolled in a multicenter, double-blind, randomized saline placebo controlled trial...
September 14, 2018: Osteoarthritis and Cartilage
Christine I Seidl, Tudor A Fulga, Chris L Murphy
OBJECTIVE: To investigate the efficacy of CRISPR-Cas9 mediated editing in human chondrocytes, and to develop a genome editing approach relevant to cell-based repair. METHODS: Transfection of human articular chondrocytes (both healthy and osteoarthritic) with ribonucleoprotein complexes containing Cas9 and a crisprRNA targeting exon2 of MMP13 was performed to assess editing efficiency and effects on MMP13 protein levels and enzymatic activity. Using spheroid cultures, protein levels of a major target of MMP13, type II collagen, were assessed by western blot and immunofluorescence...
September 14, 2018: Osteoarthritis and Cartilage
Biagio Saitta, Joseph Elphingstone, Sean Limfat, Ruzanna Shkhyan, Denis Evseenko
OBJECTIVE: Upregulation of CaMKII is implicated in the pathogenesis of OA and reactivation of articular cartilage hypertrophy. However, direct inhibition of CaMKII unexpectedly augmented symptoms of OA in animal models. The role of CaMKII in OA remains unclear and requires further investigation. METHODS: Analysis of CaMKII expression was performed in normal human and OA articular chondrocytes, and signaling mechanisms were assessed in articular, fetal and PSC-derived human chondrocytes using pharmacological (KN93), peptide (AC3-I) and siRNA inhibitors of CaMKII...
September 8, 2018: Osteoarthritis and Cartilage
Ellen W van Geffen, Arjan P M van Caam, Wim Schreurs, Fons A van de Loo, Peter L E M van Lent, Marije I Koenders, Christian S Thudium, Anne C Bay-Jensen, Esmeralda N Blaney Davidson, Peter M van der Kraan
OBJECTIVE: A hallmark of osteoarthritis (OA) is degradation of articular cartilage proteoglycans. In isolated human OA chondrocytes, the anti-inflammatory cytokine Interleukin-37 (IL-37) lowers the expression of the proteolytic MMP and ADAMTS enzymes, which mediate this degradation. Therefore, we investigated if IL-37 protects against proteoglycan loss in freshly obtained human OA explants. MATERIAL AND METHODS: Human OA cartilage explants were incubated with IL-37...
September 7, 2018: Osteoarthritis and Cartilage
Qiaoyan Tan, Bo Chen, Quan Wang, Wei Xu, Yuanqiang Wang, Zhihua Lin, Fengtao Luo, Shuo Huang, Ying Zhu, Nan Su, Min Jin, Can Li, Liang Kuang, Huabing Qi, Zhenghong Ni, Zuqiang Wang, Xiaoqing Luo, Wanling Jiang, Hangang Chen, Shuai Chen, Fangfang Li, Bin Zhang, Junlan Huang, Ruobin Zhang, Kexin Jin, Xiaoling Xu, Chuxia Deng, Xiaolan Du, Yangli Xie, Lin Chen
OBJECTIVE: We previously reported that genetic ablation of Fgfr1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice, which suggests that FGFR1 is a potential targeting molecule for osteoarthritis (OA). Here, we identified R1-P1, an inhibitory peptide for FGFR1 and investigated its effect on the pathogenesis of OA in mice induced by destabilization of medial meniscus (DMM). DESIGN: Binding ability between R1-P1 and FGFR1 protein was evaluated by ELISA and molecular docking...
September 7, 2018: Osteoarthritis and Cartilage
Andrew D Speirs, Kawan S Rakhra, Mary-Jo Weir Weiss, Paul E Beaulé
OBJECTIVE: Femoroacetabular impingement (FAI) involves abnormal hip biomechanics due to deformities and is associated with osteoarthritis. Bone mineral density (BMD) in the acetabulum is higher in subjects with convex femoral (cam) FAI deformities compared to control subjects. The objective of this study was to assess post-operative changes of BMD with and without surgical correction of the cam deformity. DESIGN: Thirteen patients with bilateral cam deformities but unilateral symptoms underwent pre-operative and follow-up CT scans of both hips...
September 6, 2018: Osteoarthritis and Cartilage
S C M van Dalen, N N L Kruisbergen, B Walgreen, M M A Helsen, A W Slöetjes, N A J Cremers, M I Koenders, F A J van de Loo, J Roth, T Vogl, A B Blom, P M van der Kraan, P L E M van Lent, M H J van den Bosch
OBJECTIVE: Synovitis in collagenase-induced osteoarthritis (CiOA) is driven by locally released S100A8/A9 proteins and enhances joint destruction. S100A8/A9 can induce reactive oxygen species (ROS) release by phagocytes in OA synovium via neutrophil cytosolic factor-1 (Ncf1)-regulated NOX2 activation. In the present study we investigated whether NOX2-derived ROS affect joint pathology during CiOA. METHODS: CiOA was induced in knee joints of wild type (WT) and Ncf1-deficient (Ncf1**) mice...
September 5, 2018: Osteoarthritis and Cartilage
Lianne Zevenbergen, Willy Gsell, Deva D Chan, Jos Vander Sloten, Uwe Himmelreich, Corey P Neu, Ilse Jonkers
OBJECTIVE: The objective of this study was to evaluate the effect of full-thickness chondral defects on intratissue deformation patterns and matrix constituents in an experimental model mimicking in vivo cartilage-on-cartilage contact conditions. DESIGN: Pairs of bovine osteochondral explants, in a unique cartilage-on-cartilage model system, were compressed uniaxially by 350N during 2s loading and 1.4s unloading cycles (≈1700 repetitions). Tissue deformations under quasi-steady state load deformation response were measured with displacement encoded imaging with stimulated echoes (DENSE) in a 9...
September 5, 2018: Osteoarthritis and Cartilage
J Chang, Z Zhu, Z Liao, T Meng, S Zheng, F Cicuttini, T Winzenberg, A Wluka, D Jiang, W Han, C Ding
OBJECTIVES: To validate a method to measure the morphological parameters of the proximal tibiofibular joint (PTFJ) in patients with knee osteoarthritis (OA). METHODS: 408 participants were examined in this cross-sectional subject-based study. We calculated the fibular contacting area of PTFJ (S) and its projection areas onto the horizontal plane (load-bearing area, Sτ), the sagittal plane (lateral stress-bolstering area, Sφ) and the coronal plane (posterior stress-bolstering area, Sυ)...
September 5, 2018: Osteoarthritis and Cartilage
M S M Persson, J Stocks, D A Walsh, M Doherty, W Zhang
OBJECTIVE: To compare the efficacy of topical non-steroidal anti-inflammatory drugs (NSAIDs) with topical capsaicin for pain relief in osteoarthritis (OA). DESIGN: A systematic literature search was conducted for randomised controlled trials (RCTs) examining any topical NSAID or capsaicin in OA. Pain relief at or nearest to 4 weeks was pooled using a random-effects network meta-analysis (NMA) in a Frequentist and Bayesian setting. Analysis was conducted for all trials and for trials using drugs listed as licensed for OA in the British National Formulary (BNF)...
August 30, 2018: Osteoarthritis and Cartilage
T McAlindon, M Roberts, J Driban, L Schaefer, I K Haugen, S E Smith, J Duryea, D Cunha, F Blanco, J-L Fernández-Garcia, C Eaton
OBJECTIVE: To evaluate the relationship of telomere length to the prevalence and incidence of hand osteoarthritis in a longitudinal cohort. DESIGN: We conducted a cross-sectional and longitudinal analysis of data from a subset of participants in the Osteoarthritis Initiative (OAI) recruited between February 2004 and May 2006. 274 individuals were eligible for the study based on availability of both baseline and 48-month hand radiographs and peripheral blood leucocyte telomere length data...
August 30, 2018: Osteoarthritis and Cartilage
L Zevenbergen, W Gsell, L Cai, D D Chan, N Famaey, J Vander Sloten, U Himmelreich, C P Neu, I Jonkers
OBJECTIVE: This study aims to characterize the deformations in articular cartilage under compressive loading and link these to changes in the extracellular matrix constituents described by magnetic resonance imaging (MRI) relaxation times in an experimental model mimicking in vivo cartilage-on-cartilage contact. DESIGN: Quantitative MRI images, T1 , T2 and T1ρ relaxation times, were acquired at 9.4T from bovine femoral osteochondral explants before and immediately after loading...
August 30, 2018: Osteoarthritis and Cartilage
F Mirahmadi, J H Koolstra, S Fazaeli, F Lobbezoo, G H van Lenthe, J Snabel, R Stoop, V Arbabi, H Weinans, V Everts
OBJECTIVE: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical properties of the temporomandibular joint (TMJ) cartilage. Hence, the aim of this study was to examine the biophysical properties (thickness, stiffness, and diffusion) of the TMJ condylar cartilage of horses of different ages and their correlation with biochemical parameters...
August 23, 2018: Osteoarthritis and Cartilage
Z Y Huang, E Perry, J L Huebner, B Katz, Y-J Li, V B Kraus
OBJECTIVE: To evaluate systemic inflammatory biomarkers in symptomatic knee osteoarthritis (OA) and their association with radiographic and biochemical OA progression. METHODS: Lipopolysaccharide (LPS) binding protein (LBP), soluble Toll-like receptor 4 (sTLR4) and interleukin 6 (IL-6) were measured in plasma of 431 knee OA patients from the doxycycline (DOXY) trial at baseline and 18 months. Plasma lipopolysaccharide and lipopolysaccharide binding protein (LBP) were also measured at 12 months...
August 23, 2018: Osteoarthritis and Cartilage
M L A Landsmeer, B C de Vos, P van der Plas, M van Middelkoop, D Vroegindeweij, P J E Bindels, E H G Oei, S M A Bierma-Zeinstra, J Runhaar
OBJECTIVE: To evaluate the effects of weight change on progression of knee osteoarthritis (OA) structural features by magnetic resonance imaging (MRI) in overweight and obese women without clinical knee OA. DESIGN: 347 participants from the Prevention of Knee Osteoarthritis in Overweight Females (PROOF) study were classified with latent class growth analysis into a subgroup with steady weight (n = 260; +0.1 ± 4.0 kg, +0.2 ± 4.4%), weight gain (n = 43; +8...
August 23, 2018: Osteoarthritis and Cartilage
M P Jansen, G S van der Weiden, P M Van Roermund, R J H Custers, S C Mastbergen, F P J G Lafeber
OBJECTIVE: Knee joint distraction (KJD), a joint-preserving surgery for severe osteoarthritis (OA), provides clinical and structural improvement and postpones the need for total knee arthroplasty (TKA). This study evaluates 9-year treatment outcome and identifies characteristics predicting long-term treatment success. DESIGN: Patients with severe tibiofemoral OA (n = 20; age<60 years) indicated for TKA were treated with KJD. Questionnaires, radiographs, and magnetic resonance imaging (MRI) were used for evaluation...
August 21, 2018: Osteoarthritis and Cartilage
E Halilaj, Y Le, J L Hicks, T J Hastie, S L Delp
OBJECTIVE: The goal of this study was to model the longitudinal progression of knee osteoarthritis (OA) and build a prognostic tool that uses data collected in 1 year to predict disease progression over 8 years. DESIGN: To model OA progression, we used a mixed-effects mixture model and 8-year data from the Osteoarthritis Initiative (OAI)-specifically, joint space width measurements from X-rays and pain scores from the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire...
August 18, 2018: Osteoarthritis and Cartilage
Q Liu, S Wang, J Lin, Y Zhang
OBJECTIVE: To estimate the burden of knee osteoarthritis (OA) among Chinese population. DESIGN: Individuals with symptomatic knee OA based on self-reported physician-diagnosed arthritis and presence of knee pain were identified in China Health and Retirement Longitudinal Study. Severity of knee OA was divided into three categories: mild, moderate and severe, according to knee pain severity. We estimated sex-specific years lived with disability (YLD) and YLD rate (per 100,000 population) by multiplying the prevalence of knee OA with appropriate disability weight (DW) and examined associations between several key sociodemographic factors and YLDs...
August 18, 2018: Osteoarthritis and Cartilage
F E Watt, N Corp, S R Kingsbury, R Frobell, M Englund, D T Felson, M Levesque, S Majumdar, C Wilson, D J Beard, L S Lohmander, V B Kraus, F Roemer, P G Conaghan, D J Mason
OBJECTIVE: There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points to consider for the design and conduct of interventional studies following acute knee injury. DESIGN: An evidence review on acute knee injury interventional studies to prevent PTOA was presented to the group, alongside overviews of challenges in this area, including potential targets, biomarkers and imaging...
August 18, 2018: Osteoarthritis and Cartilage
F Pan, J Tian, D Aitken, F Cicuttini, G Jones
OBJECTIVES: To identify distinct pain trajectories over 10.7 years and to examine predictors of identified pain trajectories in an older population and those with radiographic knee osteoarthritis (ROA). METHODS: 963 participants (aged 50-80 years) from a population-based cohort had baseline demographic, psychological, lifestyle and comorbidities data collected. T1-and T2-weighted magnetic resonance imaging (MRI) of the right knee was performed to measure knee structural pathology-cartilage defects, bone marrow lesions (BMLs) and effusion-synovitis...
August 17, 2018: Osteoarthritis and Cartilage
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