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Osteoarthritis and Cartilage

André Leumann, Timothy Leonard, Corina Nüesch, Monika Horisberger, Annegret Mündermann, Walter Herzog
OBJECTIVE: The aim of this study was to document the natural history of development and long-term progression of osteoarthritis (OA) in the feline knee after minimally invasive anterior cruciate ligament (ACL) transection. DESIGN: ACL transections of the left knee joint of 14 skeletally mature cats were performed. Radiographic scores, tibiofemoral and patellofemoral joint space and anterior tibial translation were assessed before, immediately and every 3months after ACL transection (longest follow-up: 93months)...
January 11, 2019: Osteoarthritis and Cartilage
Rasmus Elsoe, Martin B Johansen, Peter Larsen
OBJECTIVE: This study aims to investigate the risk of total knee replacement (TKR) following tibia plateau fractures. Secondary the study aims to investigate the risk of knee arthroscopy following tibial plateau fractures. METHOD: The study was designed as a matched cohort study. All patients who sustained a tibial plateau fracture in Denmark between January 1, 1996, and December 31, 2000, were included and followed until December 31, 2015. For each patient with a tibial plateau fracture, 10 matched citizens without a tibial plateau fracture were included as a reference group...
January 8, 2019: Osteoarthritis and Cartilage
Karin Magnusson, Aleksandra Turkiewicz, Martin Englund
OBJECTIVE: 1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and 2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). METHODS: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62 490 twins aged 35 years or older with a follow-up period of up to 47 years (10 092 identical and 21 153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women...
January 8, 2019: Osteoarthritis and Cartilage
Erik A Wikstrom, Kyeongtak Song, Joshua N Tennant, Katherine M Dederer, Chinmay Paranjape, Brian Pietrosimone
OBJECTIVE: To determine if individuals with chronic ankle instability (CAI) demonstrate different talar cartilage T1ρ relaxation times compared to uninjured controls. DESIGN: Fifteen CAI (21.13±1.81 years, 4.00±2.07 previous ankle sprains) and fifteen controls (21.07±2.55 years, no previous ankle sprains) participated. CAI inclusion criteria was in accordance with the International Ankle Consortium guidelines. Greater T1ρ relaxation times were interpreted as greater degenerative changes...
January 8, 2019: Osteoarthritis and Cartilage
Bola Ajekigbe, Kathleen Cheung, Yaobo Xu, Andrew J Skelton, Andreas Panagiotopoulos, Jamie Soul, Timothy E Hardingham, David J Deehan, Matt J Barter, David A Young
OBJECTIVE: Long intergenic non-coding RNAs (lincRNAs) are emerging as key regulators in gene expression; however, little is known about the lincRNA expression changes that occur in osteoarthritis (OA). Here we aimed to define a transcriptome of lncRNAs in OA cartilage, specifically comparing the lincRNA transcriptome of knee and hip cartilage. METHOD: RNA-seq was performed on nucleic acid extracted from hip cartilage from patients undergoing joint replacement surgery because of either OA (n=10) or because of a neck of femur fracture (NOF; n=6)...
January 3, 2019: Osteoarthritis and Cartilage
Patrick Omoumi, Hugo Babel, Brigitte M Jolles, Julien Favre
OBJECTIVE: To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with CT arthrography. METHODS: CT arthrograms of 50 non-OA (18 males, 58.7±6.6 years) and 50 severe medial OA (24 males, 60.5±10.7 years) knees, were retrospectively analyzed. Bone and cartilage were segmented using custom-designed software, leading to 3D models on which each point of the subchondral surface is given a CTh and sBMD value...
January 3, 2019: Osteoarthritis and Cartilage
S M Lockwood, D M Lopes, S B McMahon, A H Dickenson
OBJECTIVE: Pain is the main reason patients report Osteoarthritis (OA), yet current analgesics remain relatively ineffective. This study investigated both peripheral and central mechanisms that lead to the development of OA associated chronic pain. DESIGN: The monoiodoacetate (MIA) model of OA was investigated at early (2-6 days post injection) and late (>14 days post injection) time points. Pain-like behaviour and knee histology were assessed to understand the extent of pain due to cartilage degradation...
January 3, 2019: Osteoarthritis and Cartilage
Michael Thomas, Zack Fronk, Andrew Gross, Danielle Willmore, Alejandro Arango, Charles Higham, Victoria Nguyen, Hana Lim, Vijay Kale, Glen McMillan, Robert E Seegmiller
OBJECTIVE: Transforming growth factor beta 1 (TGF-β1) is implicated in osteoarthritis (OA). The purpose of this study was to explore the ability of Losartan to inhibit the inflammatory signaling pathway of TGF-β1 observed during osteoarthritic progression in the temporomandibular joint (TMJ) and knee joint using a genetic mouse model. METHODS: A murine OA model displaying the heterozygous chondrodysplasia gene (cho/+), a col11a1 mutation, was used to test this hypothesis...
January 2, 2019: Osteoarthritis and Cartilage
Laura A Wyatt, Lilian N Nwosu, Deborah Wilson, Roger Hill, Ian Spendlove, Andrew J Bennett, Brigitte E Scammell, David A Walsh
OBJECTIVE: Osteoarthritis (OA) is a major source of knee pain. Mechanisms of OA knee pain are incompletely understood but include synovial pathology. We aimed to identify molecular expression patterns in the synovium associated with symptomatic knee OA. DESIGN: Snap frozen synovia were from people undergoing total knee replacement (TKR) for advanced OA, or from post-mortem (PM) cases who had not sought help for knee pain. Associations with OA symptoms were determined using discovery and validation samples, each comprising TKR and PM cases matched for chondropathy (Symptomatic or Asymptomatic Chondropathy)...
December 28, 2018: Osteoarthritis and Cartilage
Louis E DeFrate, Sophia Y Kim-Wang, Zoë A Englander, Amy L McNulty
OBJECTIVE: To review recent biomechanics literature focused on the interactions between biomechanics and articular cartilage health, particularly focused on macro-scale and human studies. DESIGN: A literature search was conducted in PubMed using the search terms (biomechanics AND osteoarthritis) OR (biomechanics AND cartilage) OR (mechanics AND osteoarthritis) OR (mechanics AND cartilage) for publications from April 2017 to April 2018. RESULTS: Abstracts from the 493 articles generated from the literature search were reviewed...
December 28, 2018: Osteoarthritis and Cartilage
Jie Wei, Doug Gross, Nancy E Lane, Na Lu, Molin Wang, Chao Zeng, Tuo Yang, Guanghua Lei, Hyon K Choi, Yuqing Zhang
OBJECTIVE: To evaluate the etiologic heterogeneity between medial and lateral tibiofemoral radiographic osteoarthritis (ROA). METHODS: Knees without medial or lateral tibiofemoral ROA at baseline were followed for 60-month in Multicenter Osteoarthritis Study (MOST) and for 48-month in Osteoarthritis Initiative (OAI). We examined the relation of previously reported risk factors to incident medial and lateral tibiofemoral ROA separately and determined the etiology heterogeneity with a ratio of rate ratios (RRs) (i...
December 28, 2018: Osteoarthritis and Cartilage
Barbara Gandek, Ewa M Roos, Patricia D Franklin, John E Ware
OBJECTIVE: To develop 12-item short forms (KOOS-12, HOOS-12) of the 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) and 40-item Hip disability and Osteoarthritis Outcome Score (HOOS) that represent the full-length instruments sufficiently to provide joint-specific pain, function and quality of life (QOL) domain and summary joint impact scores. This paper describes KOOS-12 and HOOS-12 item selection. Subsequent papers will examine KOOS-12 and HOOS-12 reliability, validity and responsiveness...
December 26, 2018: Osteoarthritis and Cartilage
J A Collins, L Arbeeva, S Chubinskaya, R F Loeser
OBJECTIVE: To compare key intracellular redox-regulated signaling pathways in chondrocytes derived from knee joint femoral cartilage and ankle joint talar cartilage in order to determine if differences exist that might contribute to the lower prevalence of ankle OA. METHODS: Femoral and talar chondrocytes were treated with H2 O2 generators (menadione or 2-3-dimethoxy-1,4-napthoquinone (DMNQ), fragments of fibronectin (FN-f)) to stimulate MAP kinase signaling (MAPK), or with IGF-1 to stimulate the Akt signaling pathway...
December 24, 2018: Osteoarthritis and Cartilage
Miika T Nieminen, Victor Casula, Mika T Nevalainen, Simo S Saarakkala
PURPOSE: To provide a narrative review of the most relevant original research published in 2017/2018 on osteoarthritis imaging. METHODS: The PubMed database was used to recover all relevant articles pertaining to osteoarthritis and medical imaging published between 1 April 2017 and 31 March 2018. Review articles, case studies and in vitro or animal studies were excluded. The original publications were subjectively sorted based on relevance, novelty and impact. RESULTS AND CONCLUSIONS: The publication search yielded 1155 references...
December 24, 2018: Osteoarthritis and Cartilage
Lauren E Kanko, Trevor B Birmingham, Dianne M Bryant, Kirstie Gillanders, Kirsten Lemmon, Ryan Chan, Mike Postic, J Robert Giffin
OBJECTIVES: Despite the recognized importance of neuromuscular exercises, there is currently no widely accepted clinical outcome measure focused on neuromuscular control for patients with knee osteoarthritis (OA). The purposes of the present study were to investigate the test-retest reliability, concurrent validity and longitudinal validity of the star excursion balance test (SEBT) in patients with knee OA. DESIGN: 74 patients performed the SEBT on two sessions within seven days, and on a third session after completing 12 weeks of a home exercise program focused on neuromuscular control...
December 24, 2018: Osteoarthritis and Cartilage
Rebecca J Cleveland, Carolina Alvarez, Todd A Schwartz, Elena Losina, Jordan B Renner, Joanne M Jordan, Leigh F Callahan
OBJECTIVE: To investigate the impact of knee osteoarthritis (OA) and/or knee pain on excess mortality. METHOD: We analyzed data from 4,182 participants in a community-based prospective cohort study of African American and Caucasian men and women aged ≥45 years. Participants completed knee radiographs and questionnaires at baseline and at up to 3 follow-ups to determine knee OA (rOA), knee pain and covariate status. Mortality was determined through 2015. We used Cox proportional hazards regression with time-varying covariates to estimate hazard ratios and 95% confidence intervals...
December 21, 2018: Osteoarthritis and Cartilage
Natasha L A Fell, Bernard M Lawless, Sophie C Cox, Megan E Cooke, Neil M Eisenstein, Duncan E T Shepherd, Daniel M Espino
OBJECTIVE: Viscoelastic properties of articular cartilage have been characterised at physiological frequencies. However, studies investigating the interaction between cartilage and subchondral bone and the influence of underlying bone histomorphometry on the viscoelasticity of cartilage are lacking. METHOD: Dynamic Mechanical Analysis has been used to quantify the dynamic viscoelasticity of bovine tibial plateau osteochondral cores, over a frequency sweep from 1 - 88 Hz...
December 18, 2018: Osteoarthritis and Cartilage
M A Karsdal, K M Verburg, C R West, A C Bay-Jensen, D S Keller, R H G P Arends
There is a need for efficacious and safe pain treatments for OA (osteoarthritis). The nerve growth factor (NGF) antibody tanezumab is associated with high efficacy, but when combined with chronic NSAID treatment shows an increased risk of rapidly progressive osteoarthritis (RPOA) in a small group of patients. AIM: The aim of this study was to phenotype with biochemical biomarkers of bone, cartilage, soft tissue, synovial metabolism OA patients who are at risk of developing RPOA type-2, for both limited and chronic NSAIDs users...
December 18, 2018: Osteoarthritis and Cartilage
V T Nguyen, C Superchi, I Boutron
No abstract text is available yet for this article.
December 18, 2018: Osteoarthritis and Cartilage
D R Haudenschild, A K Carlson, D L Zignego, J H N Yik, J K Hilmer, R K June
OBJECTIVE: Although joint injury itself damages joint tissues, a substantial amount of secondary damage is mediated by the cellular responses to the injury. Cellular responses include the production and activation of proteases (MMPs, ADAMTSs, Cathepsins), and the production of inflammatory cytokines. The trajectory of cellular responses is driven by the transcriptional activation of early response genes, which requires Cdk9-dependent RNA Polymerase II phosphorylation. Our objective was to determine whether inhibition of cdk9-dependent early response gene activation affects changes in the joint metabolome...
December 18, 2018: Osteoarthritis and Cartilage
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