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Osteoarthritis and Cartilage

Gang Zheng, Zongyou Pan, Yu Zhan, Qian Tang, Fanghong Zheng, Yifei Zhou, Yaosen Wu, Yulong Zhou, Deheng Chen, Jiaoxiang Chen, Xiangyang Wang, Weiyang Gao, Huazi Xu, Naifeng Tian, Xiaolei Zhang
OBJECTIVE: Excessive apoptosis and senescence of nucleus pulposus (NP) cells are major pathological changes in intervertebral disc degeneration (IVDD) development; previous studies demonstrated pharmacologically or genetically stimulation of autophagy may inhibit apoptosis and senescence in NP cells. Transcription factor EB (TFEB) is a master regulator of autophagic flux via initiating autophagy-related genes and lysosomal biogenesis. This study was performed to confirm whether TFEB was involved in IVDD development and its mechanism...
November 8, 2018: Osteoarthritis and Cartilage
Nobuhiro Kamiya, Gen Kroyanagi, Olumide Aruwajoye, Harry K W Kim
OBJECTIVE: Juvenile ischemic osteonecrosis (JIO) of the femoral head is one of the most serious hip disorders causing a permanent deformity of the femoral head in childhood. We recently reported that interleukin 6 (IL6) is predominantly increased in the hip synovial fluid of patients with JIO and that articular chondrocytes are primary source of IL6. This study investigated whether an inhibition of IL6 receptor improves cartilage preservation and bone healing in JIO. METHOD: A small animal model (i...
November 4, 2018: Osteoarthritis and Cartilage
Huiqin Hao, Junfeng Zhang, Qianqian He, Ze Wang
OBJECTIVE: This study was design to examine the diagnostic performance of cartilage oligomeric matrix protein (COMP), C-terminal cross-linking telopeptide of type II collagen (CTX-II), and matrix metalloproteinase-3 (MMP-3) as biomarker for knee and hip OA. METHODS: Systematic search on multiple databases was completed in January 2018 using certain keywords. COMP, CTX-II, MMP-3 levels in knee and hip OA patients and healthy individuals were collected and calculated...
November 1, 2018: Osteoarthritis and Cartilage
Peter R Lawrenson, Kay M Crossley, Bill T Vicenzino, Paul W Hodges, Greg James, Kate J Croft, Matthew G King, Adam I Semciw
OBJECTIVE: To synthesise and evaluate the current evidence investigating muscle size and composition in non-inflammatory articular hip pathology. METHODS: A systematic review of five electronic databases, using three concepts; articular hip pathology (e.g osteoarthritis (OA)); hip muscles; and outcomes (e.g. muscle size and adiposity) was undertaken. Studies addressing non-inflammatory or non-traumatic articular hip pain, using measures of muscle size and adiposity were included and appraised for risk of bias...
October 30, 2018: Osteoarthritis and Cartilage
F Eckstein, S Maschek, F W Roemer, G N Duda, L Sharma, W Wirth
OBJECTIVE: To test whether radiographically normal knees with contralateral radiographic knee osteoarthritis (OA), but without contralateral trauma history, display greater cartilage thickness loss than knees from subjects with bilaterally radiographically normal knees. METHODS: 828 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative [OAI] were studied; 150 case knees displayed definite radiographic knee OA (KLG ≥ 2) contralaterally, and had MRI double echo steady state (DESS) images available at 12 and 48 month follow-up...
October 28, 2018: Osteoarthritis and Cartilage
P J Cope, K Ourradi, Y Li, M Sharif
Osteoarthritis (OA) is a chronic degenerative disease of diarthrodial joints most commonly affecting people over the age of forty. The causes of OA are still unknown and there is much debate in the literature as to the exact sequence of events that trigger the onset of the heterogeneous disease we recognise as OA. There is currently no consensus model for OA that naturally reflects human disease. Existing ex-vivo models do not incorporate the important inter-tissue communication between joint components required for disease progression and differences in size, anatomy, histology and biomechanics between different animal models makes translation to the human model very difficult...
October 25, 2018: Osteoarthritis and Cartilage
M Unal, O Akkus, J Sun, L Cai, U L Erol, L Sabri, C P Neu
OBJECTIVE: Probing the change in water content is an emerging approach to assess early diagnosis of osteoarthritis (OA). We herein developed a new method to assess hydration status of cartilage nondestructively using Raman spectroscopy (RS), and showed association of Raman-based water and organic content measurement with mechanical properties of cartilage. We further compared Raman-based water measurement to gravimetric and magnetic resonance imaging (MRI)-based water measurement. DESIGN: Eighteen cadaveric human articular cartilage plugs from 6 donors were evenly divided into two age groups: young (n = 9, mean age: 29...
October 22, 2018: Osteoarthritis and Cartilage
L A Deveza, A Downie, J G Tamez-Peña, F Eckstein, W E Van Spil, D J Hunter
OBJECTIVE: There is significant variability in the trajectory of structural progression across people with knee osteoarthritis (OA). We aimed to identify distinct trajectories of femorotibial cartilage thickness over 2 years and develop a prediction model to identify individuals experiencing progressive cartilage loss. METHODS: We analysed data from the Osteoarthritis Initiative (OAI) (n = 1,014). Latent class growth analysis (LCGA) was used to identify trajectories of medial femorotibial cartilage thickness assessed on magnetic resonance imaging (MRI) at baseline, 1 and 2 years...
October 19, 2018: Osteoarthritis and Cartilage
Kevin Kn Ho, Paulo H Ferreira, Marina B Pinheiro, Danielle Aquino Silva, Christopher B Miller, Ron Grunstein, Milena Simic
OBJECTIVES: To determine if sleep interventions improve pain and sleep in people with osteoarthritis and/or spinal pain compared to control/placebo. DESIGN: Medline, Embase, AMED, PsycINFO, CENTRAL, CINAHL and PEDro were searched from their inception date to July 2017. Keywords relating to "sleep", "osteoarthritis", "spinal pain", and "randomized controlled trial" were combined. Included RCTs investigated the use of sleep interventions for people with osteoarthritis and/or spinal pain, and measured at least one sleep and health related outcome...
October 17, 2018: Osteoarthritis and Cartilage
Daniel Pinto, Ulf Bockenholt, Julia Lee, Rowland W Chang, Leena Sharma, Daniel J Finn, Allen W Heinemann, Jane L Holl, Paul Hansen
OBJECTIVE: To investigate individual preferences or characteristics for physical activity (PA) attributes in adults with chronic knee pain, to identify clusters of individuals with similar preferences, and to identify whether individuals in these clusters differ by their demographic and health characteristics. DESIGN: An adaptive conjoint analysis was conducted using the PAPRIKA method to determine preference weights representing the relative importance of six physical activity attributes...
October 15, 2018: Osteoarthritis and Cartilage
D C Ackland, M Denton, A G Schache, M G Pandy, K M Crossley
OBJECTIVE: The aims of this study were twofold: firstly, to compare hip abductor muscle volumes in individuals with patellofemoral joint (PFJ) osteoarthritis (PFJ OA) against those of healthy controls; and secondly, to determine whether hip muscle volumes and hip kinematics during walking are related in individuals with PFJ OA and healthy controls. METHODS: Fifty-one individuals with PFJ OA and thirteen asymptomatic, age-matched healthy controls ≥40 years were recruited...
October 12, 2018: Osteoarthritis and Cartilage
J Laudon, J L Whittaker, G Ren, J L Jaremko, C A Emery, R J Krawetz
OBJECTIVE: This study investigates the relationship between a youth sport-related intra-articular knee injury and cartilage oligomeric matrix protein (COMP), a biomarker of cartilage turnover. DESIGN: Participants included a sub-sample (n = 170) of the Alberta Youth Prevention of Early Osteoarthritis (PrE-OA) study group. Specifically, 85 individuals with a 3-10 year history of sport-related intra-articular knee injury and 85 age, sex and sport-matched controls...
October 11, 2018: Osteoarthritis and Cartilage
C Deckers, P Stephan, K E Wever, C R Hooijmans, G Hannink
OBJECTIVE: It is unclear if anterior cruciate ligament (ACL) reconstruction can prevent the onset of degenerative changes in the knee. Previous studies were inconclusive on this subject. The aim of this study was to systematically review all studies on the effect of ACL reconstruction on articular cartilage in animals. DESIGN: Pubmed and Embase were searched to identify all original articles concerning the effect of ACL reconstruction on articular cartilage compared with both its positive (ACL transection) and negative (sham and/or non-operated) control in animals...
October 11, 2018: Osteoarthritis and Cartilage
M Buhler, C M Chapple, S Stebbings, B Sangelaji, G D Baxter
OBJECTIVE: To examine the effectiveness of splinting for reducing pain and improving function and health-related quality of life (HR-QoL) in people with thumb carpometacarpal osteoarthritis (CMC OA). DESIGN: The Cochrane Library, MEDLINE, Embase, CINAHL, ISI Web of Science, Scopus and Google Scholar, 3 trial registries and 4 conference proceedings were systematically searched for randomised and non-randomised controlled trials up to March 17th, 2018. Two reviewers independently applied the inclusion criteria to select potential studies and assess risk of methodologic bias using the Cochrane Collaboration's Risk of Bias Tool...
October 11, 2018: Osteoarthritis and Cartilage
M K J Jaggard, C L Boulangé, P Akhbari, U Vaghela, R Bhattacharya, H R T Williams, J C Lindon, C M Gupte
OBJECTIVE: To perform a systematic review of the small molecule metabolism studies of osteoarthritis utilising nuclear magnetic resonance (NMR) or mass spectroscopy (MS) analysis (viz., metabolomics or metabonomics), thereby providing coherent conclusions and reference material for future study. METHOD: We applied PRISMA guidelines (PROSPERO 95068) with the following MESH terms: 1. "osteoarthritis" AND ("metabolic" OR "metabonomic" OR "metabolomic" OR "metabolism") 2...
October 1, 2018: Osteoarthritis and Cartilage
H E Kloefkorn, B Y Jacobs, D F Xie, K D Allen
OBJECTIVE: In osteoarthritis (OA) models, histology is commonly used to evaluate the severity of joint damage. Unfortunately, semi-quantitative histological grading systems include some level of subjectivity, and quantitative grading systems can be tedious to implement. The objective of this work is to introduce an open source, graphic user interface (GUI) for quantitative grading of knee OA. METHODS: Inspired by the 2010 OARSI histopathology recommendations for the rat, our laboratory has developed a GUI for the evaluation of knee OA, nicknamed GEKO...
October 1, 2018: Osteoarthritis and Cartilage
S Kauppinen, S S Karhula, J Thevenot, T Ylitalo, L Rieppo, I Kestilä, M Haapea, I Hadjab, M A Finnilä, E Quenneville, M Garon, H K Gahunia, K P H Pritzker, M D Buschmann, S Saarakkala, H J Nieminen
OBJECTIVE: Our aim is to establish methods for quantifying morphometric properties of calcified cartilage (CC) from micro-computed tomography (μCT). Furthermore, we evaluated the feasibility of these methods in investigating relationships between osteoarthritis (OA), tidemark surface morphology and open subchondral channels (OSCCs). METHOD: Samples (n = 15) used in this study were harvested from human lateral tibial plateau (n = 8). Conventional roughness and parameters assessing local 3-dimensional (3D) surface variations were used to quantify the surface morphology of the CC...
October 1, 2018: Osteoarthritis and Cartilage
A E Kozijn, M T Tartjiono, S Ravipati, F van der Ham, D A Barrett, S C Mastbergen, N M Korthagen, F P J G Lafeber, A-M Zuurmond, I Bobeldijk, H Weinans, R Stoop
OBJECTIVE: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP (hCRP)-transgenic mouse model whether CRP itself contributes to the development of 'metabolic' OA. DESIGN: Metabolic OA was induced by feeding 12-week-old hCRP-transgenic males (hCRP-tg, n = 30) and wild-type littermates (n = 15) a 45 kcal% high-fat diet (HFD) for 38 weeks...
September 22, 2018: Osteoarthritis and Cartilage
A S Gersing, G Feuerriegel, C Holwein, J Suchowierski, D C Karampinos, B Haller, T Baum, B J Schwaiger, J S Kirschke, E J Rummeny, A B Imhoff, K Woertler, P M Jungmann
OBJECTIVE: To investigate whether T2 relaxation time measurements of cartilage repair tissue and structural changes of the knee joint are associated with subchondral bone architecture after spongiosa-augmented matrix-associated autologous chondrocyte implantation (MACI). DESIGN: Both knees of 25 patients (25.5 ± 7.8y; 10 women) were examined preoperatively and 2.7 years after unilateral spongiosa-augmented MACI with 3T magnetic resonance (MR) imaging. Cartilage composition was assessed using T2 relaxation time measurements, subchondral trabecular bone microstructure was quantified using a 3D phase-cycled balanced steady state free-precision sequence...
September 22, 2018: Osteoarthritis and Cartilage
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September 22, 2018: Osteoarthritis and Cartilage
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