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Sarah M Jacobs, Colin P McInnis, Matthew Kapeles, Shu-Hong Chang
PURPOSE: Severe vision loss is a risk of orbital surgery which physicians should counsel patients about, but the overall risk rate is unknown. This research was conducted to determine the risk of severe vision loss related to orbital surgery. DESIGN: Retrospective review. PARTICIPANTS: Patients who underwent orbital surgery at either of 2 academic medical centers between January 1994 and December 2014. METHODS: A billing database search was conducted to identify all patients who had orbital surgery during the study period, cross-checked against diagnostic codes related to vision loss...
March 15, 2018: Ophthalmology
Ibrahim Sayed-Ahmed, Juan Carlos Murillo, Pedro Monsalve, Jan Paul Ulloa, Maria P Fernandez, James Wong, George Elgart, Anat Galor, Sander R Dubovy, Carol L Karp
PURPOSE: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016...
March 15, 2018: Ophthalmology
Martha Kim, Ho-Kyung Choung, Kyoung Min Lee, Sohee Oh, Seok Hwan Kim
PURPOSE: To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy children with myopia (46 eyes). METHODS: The participants underwent fundus photography, SD OCT, and axial length (AXL) measurements every 6 months for 2 years...
March 14, 2018: Ophthalmology
Cécile Delcourt, Mélanie Le Goff, Therese von Hanno, Alireza Mirshahi, Anthony P Khawaja, Virginie J M Verhoeven, Ruth E Hogg, Eleftherios Anastosopoulos, Maria Luz Cachulo, René Höhn, Christian Wolfram, Alain Bron, Stefania Miotto, Isabelle Carrière, Johanna M Colijn, Gabriëlle H S Buitendijk, Jennifer Evans, Dorothea Nitsch, Panayiota Founti, Jennifer L Y Yip, Norbert Pfeiffer, Catherine Creuzot-Garcher, Rufino Silva, Stefano Piermarocchi, Fotis Topouzis, Geir Bertelsen, Paul J Foster, Astrid Fletcher, Caroline C W Klaver, Jean-François Korobelnik
TOPIC: To estimate the prevalence of nonrefractive visual impairment and blindness in European persons 55 years of age and older. CLINICAL RELEVANCE: Few visual impairment and blindness prevalence estimates are available for the European population. In addition, many of the data collected in European population-based studies currently are unpublished and have not been included in previous estimates. METHODS: Fourteen European population-based studies participating in the European Eye Epidemiology Consortium (n = 70 723) were included...
March 13, 2018: Ophthalmology
Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
PURPOSE: To investigate the positional change of central retinal vasculature and vascular trunk to deduce the change in the lamina cribrosa (LC) during axial elongation. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy myopic children (46 eyes). METHODS: Participants had undergone a full ophthalmologic examination and axial length measurement every 6 months for 2 years. Using spectral-domain OCT, circle scans centered around the optic disc in the glaucoma progression analysis mode, which enabled capturing of the same positions throughout the entire study period, and enhanced depth imaging of the deep optic nerve head complex were performed...
March 12, 2018: Ophthalmology
Jun Hui Lee, Lucia Rivera Sanchez, Travis Porco, Ying Han, Alejandra G de Alba Campomanes
PURPOSE: To study the correlation between corneal and scleral intraocular pressure (IOP) by pneumatonometry in pediatric patients. DESIGN: Cross-sectional study. PARTICIPANTS: Patients (age range, 0-15 years) undergoing an eye examination under anesthesia or eye surgery were recruited at the University of California, San Francisco, Benioff Children's Hospital between July 2015 and April 2016. METHODS: Intraocular pressure measurements were obtained by pneumatonometry on the central cornea and the inferonasal and inferotemporal sclera in a random order...
March 12, 2018: Ophthalmology
Bryan S Lee, David F Chang
PURPOSE: To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN: Retrospective cohort study in a single private practice. SUBJECTS: The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to September 2016. Patients were only excluded if their surgery could not be performed using a digital marking system. METHODS: All patients had cataract surgery performed in the same surgical center with a similar technique...
March 12, 2018: Ophthalmology
Lee M Jampol, Adam R Glassman, Danni Liu, Lloyd Paul Aiello, Neil M Bressler, Elia J Duh, Susan Quaggin, John A Wells, Charles C Wykoff
PURPOSE: To assess systemic vascular endothelial growth factor (VEGF)-A levels after treatment with intravitreous aflibercept, bevacizumab, or ranibizumab. DESIGN: Comparative-effectiveness trial with participants randomly assigned to 2 mg aflibercept, 1.25 mg bevacizumab, or 0.3 mg ranibizumab after a re-treatment algorithm. PARTICIPANTS: Participants with available plasma samples (N = 436). METHODS: Plasma samples were collected before injections at baseline and 4-week, 52-week, and 104-week visits...
March 7, 2018: Ophthalmology
Thomas A Berk, Matthew B Schlenker, Xavier Campos-Möller, Austin M Pereira, Iqbal Ike K Ahmed
PURPOSE: Femtosecond laser-assisted cataract surgery (FLACS) has emerged as an alternative to manual cataract surgery (MCS) for corneal incision and capsulorhexis creation, as well as nuclear fragmentation. This study compares postoperative refractive and visual outcomes in eyes receiving MCS or FLACS. DESIGN: Single-center, comparative, retrospective cohort analysis. PARTICIPANTS: Consecutive eyes receiving FLACS and MCS from July 1, 2012, to July 31, 2015, at a single tertiary care center...
March 6, 2018: Ophthalmology
Jonathan Krause, Varun Gulshan, Ehsan Rahimy, Peter Karth, Kasumi Widner, Greg S Corrado, Lily Peng, Dale R Webster
PURPOSE: Use adjudication to quantify errors in diabetic retinopathy (DR) grading based on individual graders and majority decision, and to train an improved automated algorithm for DR grading. DESIGN: Retrospective analysis. PARTICIPANTS: Retinal fundus images from DR screening programs. METHODS: Images were each graded by the algorithm, U.S. board-certified ophthalmologists, and retinal specialists. The adjudicated consensus of the retinal specialists served as the reference standard...
March 2, 2018: Ophthalmology
Zhixi Li, Yifan He, Stuart Keel, Wei Meng, Robert T Chang, Mingguang He
PURPOSE: To assess the performance of a deep learning algorithm for detecting referable glaucomatous optic neuropathy (GON) based on color fundus photographs. DESIGN: A deep learning system for the classification of GON was developed for automated classification of GON on color fundus photographs. PARTICIPANTS: We retrospectively included 48 116 fundus photographs for the development and validation of a deep learning algorithm. METHODS: This study recruited 21 trained ophthalmologists to classify the photographs...
March 2, 2018: Ophthalmology
Hirofumi Sasajima, Kotaro Tsuboi, Hikari Ono, Kenta Murotani, Motohiro Kamei
No abstract text is available yet for this article.
February 28, 2018: Ophthalmology
Mamunur Rashid, Jorma Heikkonen, Arun D Singh, Tero T Kivelä
PURPOSE: To build multivariate models to assess correctly and efficiently the contribution of tumor characteristics on the rate of regression of choroidal melanomas after brachytherapy in a way that adjusts for confounding and takes into account variation in tumor regression patterns. DESIGN: Modeling of longitudinal observational data. PARTICIPANTS: Ultrasound images from 330 of 388 consecutive choroidal melanomas (87%) irradiated from 2000 through 2008 at the Helsinki University Hospital, Helsinki, Finland, a national referral center...
February 27, 2018: Ophthalmology
Hae-Young Lopilly Park, Jin Woo Kim, Chan Kee Park
OBJECTIVE: We used OCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature dropout (MvD) in glaucomatous eyes with or without disc hemorrhage (DH), and the association with changes in retinal nerve fiber layer (RNFL) thickness. DESIGN: An observational case-control study. PARTICIPANTS: Eighty-two open-angle glaucoma (OAG) eyes with DH and 68 OAG eyes without DH that underwent at least 4 serial OCT examinations were included...
February 24, 2018: Ophthalmology
Sunita Radhakrishnan, Philip P Chen, Anna K Junk, Kouros Nouri-Mahdavi, Teresa C Chen
PURPOSE: To examine the efficacy and complications of laser peripheral iridotomy (LPI) in subjects with primary angle closure (PAC). METHODS: Literature searches in the PubMed and Cochrane databases were last conducted in August 2017 and yielded 300 unique citations. Of these, 36 met the inclusion criteria and were rated according to the strength of evidence; 6 articles were rated level I, 11 articles were rated level II, and 19 articles were rated level III. RESULTS: Reported outcomes were change in angle width, effect on intraocular pressure (IOP) control, disease progression, and complications...
February 23, 2018: Ophthalmology
SriniVas R Sadda, Lisa L Tuomi, Beiying Ding, Anne E Fung, J Jill Hopkins
PURPOSE: To evaluate macular atrophy (MA) presence in the 24-month HARBOR study (NCT00891735) for neovascular age-related macular degeneration (AMD). DESIGN: Post hoc analysis of a phase 3 multicenter, prospective, randomized, double-masked, active treatment-controlled clinical trial. PARTICIPANTS: Evaluable subjects (N = 1095) with subfoveal choroidal neovascularization (CNV) secondary to neovascular AMD treated with ranibizumab 0.5 mg or 2...
February 21, 2018: Ophthalmology
Eric L Crowell, Laura Baker, Alice Z Chuang, Robert M Feldman, Nicholas P Bell, Patricia Chévez-Barrios, Lauren S Blieden
PURPOSE: To identify the presence or absence of 3 identifiable landmarks: trabecular meshwork (TM), Schlemm's canal (SC), and a novel landmark termed the band of extracanalicular limbal lamina (BELL), which is a landmark adjacent to SC visible on anterior segment (AS) OCT. These landmarks also were analyzed pathologically to identify all 3 landmarks. DESIGN: Retrospective review. PARTICIPANTS: One eye per participant from prior institutional review board-approved studies in which AS OCT imaging was performed...
February 21, 2018: Ophthalmology
Gary C Brown, Melissa M Brown, Joshua D Stein, William E Smiddy
PURPOSE: To present ophthalmic patient time-tradeoff vision utilities for quantifying vision-related quality-of-life when the fellow eye still has good vision. These utilities are important for performing reliable cost-utility analyses. DESIGN: Consecutive time-tradeoff vision utilities were obtained from ophthalmic patients with good vision (20/20-20/25) in one eye and vision ranging from 20/20 to no light perception in the fellow eye over a 15-year period from 2000 through 2014...
February 21, 2018: Ophthalmology
Kunyong Xu, Eric K Chin, Steven R Bennett, David F Williams, Edwin H Ryan, Sundeep Dev, Robert A Mittra, Polly A Quiram, John B Davies, D Wilkin Parke, Jill B Johnson, Herbert L Cantrill, David R P Almeida
PURPOSE: We describe the presentation of patients developing endophthalmitis after intravitreal injection with vascular endothelial growth factor (VEGF) inhibitors. Moreover, we evaluate the management by comparing the outcomes of immediate tap and injection of intravitreal antibiotics (TAI) versus initial surgical pars plana vitrectomy (PPV). Finally, we analyze the predictive factors of visual outcomes at 6-month follow-up. DESIGN: Retrospective, single-center, nonrandomized interventional study...
February 21, 2018: Ophthalmology
Steven J Gedde, William J Feuer, Wei Shi, Kin Sheng Lim, Keith Barton, Saurabh Goyal, Iqbal I K Ahmed, James Brandt
PURPOSE: To report 1-year treatment outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study. DESIGN: Multicenter, randomized clinical trial. PARTICIPANTS: Two hundred forty-two eyes of 242 patients with medically uncontrolled glaucoma and no previous incisional ocular surgery, including 125 in the tube group and 117 in the trabeculectomy group. METHODS: Patients were enrolled at 16 clinical centers and assigned randomly to treatment with a tube shunt (350-mm2 Baerveldt glaucoma implant) or trabeculectomy with mitomycin C (MMC; 0...
February 21, 2018: Ophthalmology
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