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Ophthalmology

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https://www.readbyqxmd.com/read/28647203/gene-therapy-for-leber-hereditary-optic-neuropathy-low-and-medium-dose-visual-results
#1
John Guy, William J Feuer, Janet L Davis, Vittorio Porciatti, Phillip J Gonzalez, Rajeshwari D Koilkonda, Huijun Yuan, William W Hauswirth, Byron L Lam
PURPOSE: To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). DESIGN: Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND4v2 per participant. PARTICIPANTS: Fourteen patients with visual loss and mutated G11778A mitochondrial DNA. METHODS: Intravitreal injection with the gene therapy vector AAV2(Y444,500,730F)-P1ND4v2 into 1 eye...
June 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28647202/the-current-state-of-teleophthalmology-in-the-united-states
#2
REVIEW
Siddarth Rathi, Edmund Tsui, Nitish Mehta, Sarwar Zahid, Joel S Schuman
Telemedicine services facilitate the evaluation, diagnosis, and management of the remote patient. Telemedicine has rapidly flourished in the United States and has improved access to care, outcomes, and patient satisfaction. However, the use of telemedicine in ophthalmology is currently in its infancy and has yet to gain wide acceptance. Current models of telemedicine in ophthalmology are largely performed via "store and forward" methods, but remote monitoring and interactive modalities exist. Although studies have examined the effects of telemedicine, few reports have characterized its current status...
June 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28647201/axis-misalignment-of-toric-intraocular-lens-placement-error-and-postoperative-rotation
#3
Yasushi Inoue, Hiroyasu Takehara, Tetsuro Oshika
No abstract text is available yet for this article.
June 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28625685/objective-quantification-of-anterior-chamber-inflammation-measuring-cells-and-flare-by-anterior-segment-optical-coherence-tomography
#4
Alessandro Invernizzi, Sylvia Marchi, Raffaella Aldigeri, Valentina Mastrofilippo, Fabiana Viscogliosi, Annamaria Soldani, Chantal Adani, Elena Garoli, Francesco Viola, Luigi Fontana, Peter McCluskey, Luca Cimino
PURPOSE: To assess the ability of swept-source (SS) optical coherence tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both flare and cells) objectively. To compare OCT-derived inflammatory indices with standard techniques. DESIGN: Prospective evaluation of a diagnostic test. PARTICIPANTS: Patients diagnosed with anterior uveitis (active or inactive) and controls. METHODS: Participants underwent an AC inflammation evaluation including: clinical cell and flare grading and laser flare photometry (LFP)...
June 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28625684/brand-medications-and-medicare-part-d-how-eye-care-providers-prescribing-patterns-influence-costs
#5
Paula Anne Newman-Casey, Maria A Woodward, Leslie M Niziol, Paul P Lee, Lindsey B De Lott
PURPOSE: To quantify costs of eye care providers' Medicare Part D prescribing patterns for ophthalmic medications and to estimate the potential savings of generic or therapeutic drug substitutions and price negotiation. DESIGN: Retrospective cross-sectional study. PARTICIPANTS: Eye care providers prescribing medications through Medicare Part D in 2013. METHODS: Medicare Part D 2013 prescriber public use file and summary file were used to calculate medication costs by physician specialty and drug...
June 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28624169/dynamic-change-in-optic-nerve-after-intracranial-pressure-reduction-in-children
#6
Won June Lee, Hae Jin Kim, Ki Ho Park, Yong Woo Kim, Michael J A Girard, Jean Martial Mari, Seung-Ki Kim, Ji Hoon Phi, Jin Wook Jeoung
No abstract text is available yet for this article.
June 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28624168/antibiotic-prescription-fills-for-acute-conjunctivitis-among-enrollees-in-a-large-united-states-managed-care-network
#7
Nakul S Shekhawat, Roni M Shtein, Taylor S Blachley, Joshua D Stein
PURPOSE: Antibiotics are seldom necessary to treat acute conjunctivitis. We assessed how frequently patients with newly diagnosed acute conjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiotic prescription fills. DESIGN: Retrospective, observational cohort study. PARTICIPANTS: A total of 340 372 enrollees in a large nationwide United States managed care network with newly diagnosed acute conjunctivitis, from 2001 through 2014...
June 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28624167/longitudinal-vision-related-quality-of-life-for-patients-with-noninfectious-uveitis-treated-with-fluocinolone-acetonide-implant-or-systemic-corticosteroid-therapy
#8
Elizabeth A Sugar, Vidya Venugopal, Jennifer E Thorne, Kevin D Frick, Gary N Holland, Robert C Wang, Robert Almanzor, Douglas A Jabs, Janet T Holbrook
PURPOSE: To evaluate longitudinal vision-related quality of life (VRQoL) in patients with noninfectious uveitis. DESIGN: Cohort study using randomized controlled trial data. PARTICIPANTS: Patients with active or recently active intermediate uveitis, posterior uveitis, or panuveitis enrolled in the Multicenter Steroid Treatment Trial and Follow-up Study. METHODS: Data from the 25-item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) for the first 3 years after randomization were evaluated semiannually...
June 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28615113/risk-factors-and-long-term-outcomes-in-patients-with-low-intraocular-pressure-after-trabeculectomy
#9
Victoria L Tseng, Carole H Kim, Pablo T Romero, Fei Yu, Kenneth W Robertson-Brown, Lam Phung, Daniel Raygoza, Joseph Caprioli, Anne L Coleman
PURPOSE: To examine risk factors for low intraocular pressure (IOP) after trabeculectomy and to describe long-term outcomes in these eyes. DESIGN: Retrospective case-control study. PARTICIPANTS: Cases with low IOP included all patients with IOP ≤5 mmHg on 3 or more consecutive visits 3 months or later after trabeculectomy. Control patients without low IOP after trabeculectomy were randomly selected at a 1:2 case-to-control ratio. METHODS: A case-control study was performed of patients undergoing trabeculectomy at the Stein Eye Institute...
June 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28602520/decreased-visual-function-scores-on-a-low-luminance-questionnaire-is-associated-with-impaired-dark-adaptation
#10
Mohammad Yazdanie, Jason Alvarez, Elvira Agrón, Wai T Wong, Henry E Wiley, Frederick L Ferris, Emily Y Chew, Catherine Cukras
PURPOSE: We investigate whether responses on a Low Luminance Questionnaire (LLQ) in patients with a range of age-related macular degeneration (AMD) severity are associated with their performance on focal dark adaptation (DA) testing and with choroidal thickness. DESIGN: Cross-sectional, single-center, observational study. PARTICIPANTS: A total of 113 participants older than 50 years of age with a range of AMD severity. METHODS: Participants answered the LLQ on the same day they underwent DA testing using a focal dark adaptometer measuring rod intercept time (RIT)...
June 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28601250/efficacy-safety-and-risk-factors-for-failure-of-standalone-ab-interno-gelatin-microstent-implantation-versus-standalone-trabeculectomy
#11
Matthew B Schlenker, Husayn Gulamhusein, Ina Conrad-Hengerer, Alix Somers, Markus Lenzhofer, Ingeborg Stalmans, Herbert Reitsamer, Fritz H Hengerer, Iqbal Ike K Ahmed
PURPOSE: To compare the efficacy, safety, and risk factors for failure of standalone ab interno gelatin microstent implantation with mitomycin C (MMC) versus trabeculectomy with MMC. DESIGN: International, multicenter, retrospective interventional cohort study. PARTICIPANTS: Three hundred fifty-four eyes of 293 patients (185 microstent and 169 trabeculectomy) with no prior incisional surgery. METHODS: Consecutive eyes with uncontrolled glaucoma underwent microstent or trabeculectomy surgery from January 1, 2011 through July 31, 2015 at 4 academic ophthalmology centers: Toronto, Canada; Frankfurt, Germany; Salzburg, Austria; and Leuven, Belgium...
June 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28583710/large-disparities-in-receipt-of-glaucoma-care-between-enrollees-in-medicaid-and-those-with-commercial-health-insurance
#12
Angela R Elam, Chris Andrews, David C Musch, Paul P Lee, Joshua D Stein
PURPOSE: To determine whether the type of health insurance a patient possesses and a patient's race/ethnicity affect receipt of common tests to monitor open-angle glaucoma (OAG). DESIGN: Retrospective longitudinal cohort study. PARTICIPANTS: A total of 21 766 persons aged ≥40 years with newly diagnosed OAG between 2007 and 2011 enrolled in Medicaid or a large United States managed care network. METHODS: We determined the proportion of patients with newly diagnosed OAG who underwent visual field (VF) testing, fundus photography (FP), other ocular imaging (OOI), or none of these tests within the first 15 months after initial OAG diagnosis...
June 2, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28571893/selective-serotonin-reuptake-inhibitors-and-cataract-risk-a-case-control-analysis
#13
Claudia Becker, Susan S Jick, Christoph R Meier
PURPOSE: Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with an increased cataract risk. We aimed to assess cataract risk after exposure to SSRI or to other antidepressant drugs in a large electronic primary care database. DESIGN: Case-control study. PARTICIPANTS: The study population was derived from the UK-based Clinical Practice Research Datalink (CPRD). We included patients with first-time cataract aged ≥40 years between 1995 and 2015 and an equal number of cataract-free controls matched on age, sex, general practice, date of cataract recording (i...
May 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28559085/clinically-focused-molecular-investigation-of-1000-consecutive-families-with-inherited-retinal-disease
#14
Edwin M Stone, Jeaneen L Andorf, S Scott Whitmore, Adam P DeLuca, Joseph C Giacalone, Luan M Streb, Terry A Braun, Robert F Mullins, Todd E Scheetz, Val C Sheffield, Budd A Tucker
PURPOSE: To devise a comprehensive multiplatform genetic testing strategy for inherited retinal disease and to describe its performance in 1000 consecutive families seen by a single clinician. DESIGN: Retrospective series. PARTICIPANTS: One thousand consecutive families seen by a single clinician. METHODS: The clinical records of all patients seen by a single retina specialist between January 2010 and June 2016 were reviewed, and all patients who met the clinical criteria for a diagnosis of inherited retinal disease were included in the study...
May 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28554534/ophthalmic-manifestations-of-xeroderma-pigmentosum-a-perspective-from-the-united-kingdom
#15
Rongxuan Lim, Mieran Sethi, Ana M S Morley
PURPOSE: To document the ocular manifestations of xeroderma pigmentosum (XP), presenting via the United Kingdom (UK) XP service, and to analyze the correlations between XP genotype and ophthalmic phenotype. DESIGN: Prospective observational case series. SUBJECTS: Eighty-nine patients seen by the UK Nationally Commissioned XP Service, from April 2010 to December 2014, with a genetically confirmed diagnosis of XP. METHODS: Patients underwent a full ophthalmic examination at each visit...
May 26, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551167/brolucizumab-versus-aflibercept-in-participants-with-neovascular-age-related-macular-degeneration-a-randomized-trial
#16
Pravin U Dugel, Glenn J Jaffe, Peter Sallstig, James Warburton, Andreas Weichselberger, Mark Wieland, Lawrence Singerman
PURPOSE: To compare the efficacy and safety of brolucizumab with aflibercept to treat neovascular age-related macular degeneration (AMD). DESIGN: Prospective, randomized, double-masked, multicenter, 2-arm, phase 2 study. PARTICIPANTS: Eighty-nine treatment-naïve participants, aged ≥50 years, with active choroidal neovascularization secondary to AMD. METHODS: Eligible participants were randomized 1:1 to intravitreal brolucizumab (6 mg/50 μl) or aflibercept (2 mg/50 μl)...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551166/24-2-visual-fields-miss-central-defects-shown-on-10-2-tests-in-glaucoma-suspects-ocular-hypertensives-and-early-glaucoma
#17
C Gustavo De Moraes, Donald C Hood, Abinaya Thenappan, Christopher A Girkin, Felipe A Medeiros, Robert N Weinreb, Linda M Zangwill, Jeffrey M Liebmann
PURPOSE: To investigate the prevalence of visual field defects in glaucomatous eyes, glaucoma suspects, and ocular hypertensives with 24-2 and 10-2 visual fields. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Patients with or suspected glaucoma tested with 24-2 and 10-2. Patients were classified into 3 groups on the basis of the presence of glaucomatous optic neuropathy (GON) and 24-2 visual field abnormalities: early glaucoma (GON and abnormal visual field, mean deviation >-6 decibels [dB]), glaucoma suspects (GON and normal visual field), and ocular hypertensives (normal disc, normal visual field, and intraocular pressure >22 mmHg)...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551165/securing-extraocular-muscles-in-strabismus-surgery-how-strong-is-the-sclera
#18
Steven E Brooks
No abstract text is available yet for this article.
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551164/multiple-temporal-lamina-cribrosa-defects-in-myopic-eyes-with-glaucoma-and-their-association-with-visual-field-defects
#19
Yu Sawada, Makoto Araie, Makoto Ishikawa, Takeshi Yoshitomi
PURPOSE: To investigate characteristics of lamina cribrosa (LC) defects in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Cross-sectional study. PARTICIPANTS: One hundred thirty-three eyes with OAG and 83 eyes without OAG, with axial length of 24 mm or more. METHODS: Serial enhanced depth imaging SD OCT B-scans of the optic disc were acquired and reviewed for LC defects (diameter, ≥100 μm) and large pores (diameter, 60-100 μm)...
May 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28551163/therapies-for-macular-edema-associated-with-branch-retinal-vein-occlusion-a-report-by-the-american-academy-of-ophthalmology
#20
Justis P Ehlers, Stephen J Kim, Steven Yeh, Jennifer E Thorne, Prithvi Mruthyunjaya, Scott D Schoenberger, Sophie J Bakri
PURPOSE: To evaluate the available evidence on the ocular safety and efficacy of current therapeutic alternatives for the management of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Literature searches were last conducted on January 31, 2017, in PubMed with no date restrictions and limited to articles published in English, and in the Cochrane Database without language limitations. The searches yielded 321 citations, of which 109 were reviewed in full text and 27 were deemed appropriate for inclusion in this assessment...
May 24, 2017: Ophthalmology
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