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Angelo P Tanna, Mark Johnson
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells decreased outflow resistance placed a spotlight on the Rho kinase pathway that was known to regulate the cytoskeleton...
July 11, 2018: Ophthalmology
Susan B Bressler, Wesley T Beaulieu, Adam R Glassman, Jeffrey G Gross, Michele Melia, Eric Chen, Michael R Pavlica, Lee M Jampol
PURPOSE: To identify baseline factors associated with change in visual acuity or development of vision-impairing central-involved diabetic macular edema (DME) over 2 years when treating proliferative diabetic retinopathy (PDR) with ranibizumab or panretinal photocoagulation (PRP). DESIGN: Post hoc analyses of randomized, multicenter clinical trial data. PARTICIPANTS: Eyes completing the 2-year visit (n = 328) or without vision-impairing central-involved DME at baseline (n = 302) in Diabetic Retinopathy Clinical Research Network Protocol S...
July 3, 2018: Ophthalmology
Aistė Kadziauskienė, Ernesta Jašinskienė, Rimvydas Ašoklis, Eugenijus Lesinskas, Tomas Rekašius, Jacqueline Chua, Ching-Yu Cheng, Jean Martial Mari, Michaël J A Girard, Leopold Schmetterer
PURPOSE: To evaluate changes in lamina cribrosa (LC) shape, curvature, and depth after trabeculectomy. DESIGN: Prospective, observational case series. PARTICIPANTS: A total of 112 patients (118 eyes) with open- or closed-angle glaucoma undergoing trabeculectomy. METHODS: The optic nerve head was imaged using enhanced depth imaging spectral-domain OCT before trabeculectomy and at 6 follow-up visits throughout the first postoperative year...
June 28, 2018: Ophthalmology
Winston Chamberlain, Charles C Lin, Ariana Austin, Nicholas Schubach, Jameson Clover, Stephen D McLeod, Travis C Porco, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: To compare clinical outcomes of ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) in the treatment of corneal endothelial dysfunction. DESIGN: Patient and outcome-masked, randomized controlled clinical trial. PARTICIPANTS: Patients with damaged or diseased endothelium from Fuchs endothelial dystrophy or pseudophakic bullous keratopathy who were considered good candidates for DMEK or UT-DSAEK...
June 23, 2018: Ophthalmology
Ahnul Ha, Tai Jun Kim, Michael J A Girard, Jean Martial Mari, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
PURPOSE: To investigate the relationship between the degree of posterior bowing of the lamina cribrosa (LC) at baseline and the rate of subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG). DESIGN: Prospective, observational study. PARTICIPANTS: One hundred one early-stage (VF mean deviation [MD], -5.0 to -0.01 dB) POAG eyes that met the following conditions: (1) follow-up longer than 3.5 years, (2) more than 5 reliable standard automated perimetry tests, and (3) medically well-controlled intraocular pressure during follow-up...
June 23, 2018: Ophthalmology
Thomas W Samuelson, David F Chang, Robert Marquis, Brian Flowers, K Sheng Lim, Iqbal Ike K Ahmed, Henry D Jampel, Tin Aung, Alan S Crandall, Kuldev Singh
OBJECTIVE: To compare cataract surgery with implantation of a Schlemm canal microstent with cataract surgery alone for the reduction of intraocular pressure (IOP) and medication use after 24 months. DESIGN: Prospective, multicenter, single-masked, randomized controlled trial. PARTICIPANTS: Subjects with concomitant primary open-angle glaucoma (POAG), visually significant cataract, and washed-out modified diurnal IOP (MDIOP) between 22 and 34 mmHg...
June 23, 2018: Ophthalmology
Ravi Parikh, Yoichi Sakurada, Lawrence A Yannuzzi
No abstract text is available yet for this article.
June 21, 2018: Ophthalmology
Oluwatobi O Idowu, J Minjy Kang, M Reza Vagefi
No abstract text is available yet for this article.
June 21, 2018: Ophthalmology
Regitze Bangsgaard, Katharina M Main, Gøril Boberg-Ans, Morten la Cour, Julie Lyng Forman, Birgitte Haargaard, Jens Folke Kiilgaard
PURPOSE: To analyze the incidence of adrenal suppression and the glucocorticoid (GC) dose per kilogram body weight given in infants treated with standard protocol for topical ophthalmic GCs after congenital cataract surgery. DESIGN: Retrospective, consecutive case series. PARTICIPANTS: All children younger than 2 years of age who underwent operation for congenital cataract between January 2011 and May 2015 in 1 center. METHODS: Patient charts were reviewed to collect data on results and timing of a standard corticotropin (adrenocorticotropic hormone [ACTH]) stimulation test and GC dose per kilogram body weight...
June 19, 2018: Ophthalmology
Feihui Zheng, Zhongheng Wu, Christopher K S Leung
PURPOSE: To determine the proportions of eyes with indiscernible Bruch's membrane opening (BMO) in glaucoma patients and healthy individuals with and without high myopia and to investigate factors contributing to indiscernible BMO. DESIGN: Cross-sectional study. PARTICIPANTS: Five hundred eyes from 315 participants, including 212 high myopic eyes (axial length [AL], ≥26 mm) from 80 glaucoma patients and 60 healthy individuals and 288 non-high myopic eyes (AL, <26 mm) from 96 glaucoma patients and 88 healthy individuals...
June 19, 2018: Ophthalmology
Po-Wen Ku, Andrew Steptoe, Yun-Ju Lai, Hsiao-Yun Hu, Dachen Chu, Yung-Feng Yen, Yung Liao, Li-Jung Chen
OBJECTIVE: This nationwide population-based study aimed to examine the prospective association between near visual activities and incident myopia in Taiwanese children 7 to 12 years old over a 4-year follow-up period. DESIGN: Prospective cohort design. PARTICIPANTS: There were 1958 children aged 7 to 12 years from the Taiwan 2009 National Health Interview Survey who were linked to the 2009 through 2013 claims data from the National Health Insurance system...
June 19, 2018: Ophthalmology
Fabio Lavinsky, Mengfei Wu, Joel S Schuman, Katie A Lucy, Mengling Liu, Youngseok Song, Julia Fallon, Maria de Los Angeles Ramos Cadena, Hiroshi Ishikawa, Gadi Wollstein
PURPOSE: To evaluate the ability of OCT optic nerve head (ONH) and macular parameters to detect disease progression in eyes with advanced structural glaucomatous damage of the circumpapillary retinal nerve fiber layer (cRNFL). DESIGN: Longitudinal study. PARTICIPANTS: Forty-four eyes from 37 patients with advanced average cRNFL damage (≤60 μm) followed up for an average of 4.0 years. METHODS: All patients were examined with spectral-domain OCT and visual field (VF) assessment during at least 4 visits...
June 19, 2018: Ophthalmology
William H Morgan, Barry Quill, Stephen J Cringle, Philip H House, Dao-Yi Yu
No abstract text is available yet for this article.
June 16, 2018: Ophthalmology
Lauren A Dalvin, David Ancona-Lezama, J Antonio Lucio-Alvarez, Babak Masoomian, Pascal Jabbour, Carol L Shields
PURPOSE: To assess risk factors for ophthalmic vascular events after intra-arterial chemotherapy (IAC) for retinoblastoma. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients who received unilateral IAC as primary treatment for retinoblastoma from January 1, 2009, to November 30, 2017, at a single center. METHODS: Records were reviewed for patient demographics, tumor features, IAC parameters, and treatment-related vascular events in the early IAC era (2009-2011) compared with the recent era (2012-2017) using the t test and Fisher exact test...
June 16, 2018: Ophthalmology
Sasan Moghimi, Linda M Zangwill, Rafaella C Penteado, Kyle Hasenstab, Elham Ghahari, Huiyuan Hou, Mark Christopher, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Takuhei Shoji, Christopher Bowd, Robert N Weinreb
PURPOSE: To investigate prospectively the relationship between macular and peripapillary vessel density and progressive retinal nerve fiber layer (RNFL) loss in patients with mild to moderate primary open-angle glaucoma. DESIGN: Prospective, observational study. PARTICIPANTS: One hundred thirty-two eyes of 83 patients with glaucoma followed up for at least 2 years (average: 27.3±3.36 months). METHODS: Measurements of macular whole image vessel density (m-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were acquired at baseline using OCT angiography...
June 12, 2018: Ophthalmology
Lasse Malmqvist, Patrick A Sibony, Clare L Fraser, Marianne Wegener, Steffen Heegaard, Marie Skougaard, Steffen Hamann
No abstract text is available yet for this article.
June 8, 2018: Ophthalmology
David K Wallace, Trevano W Dean, Mary Elizabeth Hartnett, Lingkun Kong, Lois E Smith, G Baker Hubbard, Mary Lou McGregor, Catherine O Jordan, Iason S Mantagos, Edward F Bell, Raymond T Kraker
PURPOSE: Intravitreal bevacizumab is increasingly used to treat severe retinopathy of prematurity (ROP), but it enters the bloodstream, and there is concern that it may alter development of other organs. Previously we reported short-term outcomes of 61 infants enrolled in a dose de-escalation study, and we report the late recurrences and additional treatments. DESIGN: Masked, multicenter, dose de-escalation study. PARTICIPANTS: A total of 61 premature infants with type 1 ROP...
June 7, 2018: Ophthalmology
Sung Uk Baek, Ko Eun Kim, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
PURPOSE: To develop a new scoring system that uses topographic diagnostic signs of spectral-domain (SD) OCT to enhance glaucoma diagnostic performance for myopic eyes and to validate the system's diagnostic ability. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 517 patients (517 eyes; spherical equivalent [SE] <-1.0 diopters [D] or axial length >24.0 mm), including 175 highly myopic eyes (SE <-6.0 D or axial length >26...
June 7, 2018: Ophthalmology
Edward J Wladis, Vinay K Aakalu, Michael T Yen, Jurij R Bilyk, Rachel K Sobel, Louise A Mawn
PURPOSE: To identify the efficacy and adverse event rates of balloon dacryoplasty in cases of congenital nasolacrimal duct obstruction in children who fail to respond to an initial nasolacrimal duct probing. METHODS: A literature search was last performed in September 2017 in the PubMed database to identify all reports of balloon dacryoplasty. All searches up to and including the last search were limited to the English language, and they yielded 104 articles that were assessed for relevancy...
June 7, 2018: Ophthalmology
David H W Steel, Javid Suleman, Declan C Murphy, Anna Song, Steve Dodds, Jon Rees
PURPOSE: To identify the incidence, presenting features, treatment, and clinical course of optic disc pit maculopathy (ODPM) in the United Kingdom (UK). DESIGN: A 2-year nationwide prospective population-based study. SUBJECTS: All new incident cases of ODPM presenting to UK ophthalmologists using the British Ophthalmic Surveillance Unit monthly reporting system. METHODS: All reporting ophthalmologists were sent an initial questionnaire requesting data on previous medical and ophthalmic history, presentation details, investigation findings, and management...
June 7, 2018: Ophthalmology
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