journal
MENU ▼
Read by QxMD icon Read
search

Ophthalmology

journal
https://www.readbyqxmd.com/read/28942074/immunosuppression-for-the-uveitides
#1
REVIEW
Douglas A Jabs
The uveitides are a collection of more than 30 diseases characterized by intraocular inflammation. Many cases of juvenile idiopathic arthritis-associated uveitis, many cases of intermediate uveitis, and most cases of posterior and panuveitides requiring treatment are treated with corticosteroids and immunosuppression. Disease-specific, time-updated modeling of clinical data for several uveitides suggests superior prevention of ocular complications and visual outcomes with immunosuppression. These studies also suggest that oral corticosteroids at doses low enough for safe long-term therapy (i...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28942073/update-on-the-management-of-infectious-keratitis
#2
REVIEW
Ariana Austin, Tom Lietman, Jennifer Rose-Nussbaumer
Infectious keratitis is a major global cause of visual impairment and blindness, often affecting marginalized populations. Proper diagnosis of the causative organism is critical, and although culture remains the prevailing diagnostic tool, newer techniques such as in vivo confocal microscopy are helpful for diagnosing fungus and Acanthamoeba. Next-generation sequencing holds the potential for early and accurate diagnosis even for organisms that are difficult to culture by conventional methods. Topical antibiotics remain the best treatment for bacterial keratitis, and a recent review found all commonly prescribed topical antibiotics to be equally effective...
September 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28935401/long-term-endothelial-cell-loss-in-patients-with-artisan-myopia-and-artisan-toric-phakic-intraocular-lenses-5-and-10-year-results
#3
Soraya M R Jonker, Tos T J M Berendschot, Annick E Ronden, Isabelle E Y Saelens, Noël J C Bauer, Rudy M M A Nuijts
PURPOSE: To evaluate the long-term change in endothelial cell density (ECD) after the implantation of 2 types of rigid iris-fixated phakic intraocular lenses (pIOLs) for the treatment of myopia and astigmatism. DESIGN: Prospective, clinical cohort study. PARTICIPANTS: A total of 507 eyes of 289 patients receiving the Artisan Myopia or Artisan Toric (Ophtec B.V., Groningen, The Netherlands) iris-fixated pIOL for the treatment of myopia or astigmatism at the University Eye Clinic Maastricht as of January 1998...
September 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28935400/adjuvant-sunitinib-in-high-risk-patients-with-uveal-melanoma-comparison-with-institutional-controls
#4
Matias E Valsecchi, Marlana Orloff, Rino Sato, Inna Chervoneva, Carol L Shields, Jerry A Shields, Michael J Mastrangelo, Takami Sato
PURPOSE: To compare overall survival in high-risk patients with primary uveal melanoma who received adjuvant sunitinib with institutional controls. DESIGN: Retrospective cohort. PARTICIPANTS: Selection criteria were (1) monosomy 3 and 8q amplification by cytogenetic or DecisionDx-UM Class 2 and (2) monosomy 3 and large tumor size (T3-4 by American Joint Committee on Cancer classification). Exclusion criteria were date of diagnosis before 2007 or after 2013 and age <18 years...
September 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28935399/optical-coherence-tomography-biomarkers-as-functional-outcome-predictors-in-diabetic-macular-edema-treated-with-dexamethasone-implant
#5
Dinah Zur, Matias Iglicki, Catharina Busch, Alessandro Invernizzi, Miriana Mariussi, Anat Loewenstein
PURPOSE: Identification and characterization of patients with diabetic macular edema (DME) are important for individualizing treatment and optimizing outcome. We investigated optical coherence tomography (OCT) biomarkers for DME treated by intravitreal dexamethasone (DEX) implant. DESIGN: Multicenter, retrospective, observational cohort study. PARTICIPANTS: A total of 299 eyes from 284 patients treated with DEX implant for DME (naïve, n = 209; refractory, n = 90)...
September 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28923499/descemet-membrane-endothelial-keratoplasty-safety-and-outcomes-a-report-by-the-american-academy-of-ophthalmology
#6
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
September 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28899574/orbital-implants-in-enucleation-surgery-a-report-by-the-american-academy-of-ophthalmology
#7
Edward J Wladis, Vinay K Aakalu, Rachel K Sobel, Michael T Yen, Jurij R Bilyk, Louise A Mawn
PURPOSE: To compare the motility and complication rates of porous and nonporous implants after enucleation surgery. METHODS: Literature searches of the PubMed and Cochrane Library databases were last performed in February 2017 to identify studies published between 2003 and 2017 on outcomes after enucleation surgeries in which a variety implants were used. The searches were limited to the English language with abstracts and yielded 43 articles, which the Ophthalmic Technology Assessment Committee Oculoplastics and Orbit Panel reviewed for relevancy...
September 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28893454/treat-and-extend-versus-monthly-regimen-in-neovascular-age-related-macular-degeneration-results-with-ranibizumab-from-the-trend-study
#8
Rufino Silva, András Berta, Michael Larsen, Wayne Macfadden, Chrystel Feller, Jordi Monés
PURPOSE: To evaluate the efficacy and safety of ranibizumab 0.5 mg treat-and-extend (T&E) versus monthly regimens in patients with neovascular age-related macular degeneration (nAMD) from the TReat and extEND (TREND) study. DESIGN: A 12-month phase 3b visual acuity (VA) assessor-masked, multicenter, randomized, interventional study. PARTICIPANTS: Six hundred fifty patients. METHODS: Treatment-naïve nAMD patients (age, ≥50 years) were randomized 1:1 to receive either a ranibizumab 0...
September 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28916333/human-plasma-metabolomics-study-across-all-stages-of-age-related-macular-degeneration-identifies-potential-lipid%C3%A2-biomarkers
#9
Inês Laíns, Rachel S Kelly, John B Miller, Rufino Silva, Demetrios G Vavvas, Ivana K Kim, Joaquim N Murta, Jessica Lasky-Su, Joan W Miller, Deeba Husain
PURPOSE: To characterize the plasma metabolomic profile of patients with age-related macular degeneration (AMD) using mass spectrometry (MS). DESIGN: Cross-sectional observational study. PARTICIPANTS: We prospectively recruited participants with a diagnosis of AMD and a control group (>50 years of age) without any vitreoretinal disease. METHODS: All participants underwent color fundus photography, used for AMD diagnosis and staging, according to the Age-Related Eye Disease Study classification scheme...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28867131/posterior-vitreous-detachment-and-the-posterior-hyaloid-membrane
#10
Gregory S Fincham, Sean James, Carl Spickett, Michael Hollingshead, Christopher Thrasivoulou, Arabella V Poulson, Annie McNinch, Allan Richards, David Snead, Gloria A Limb, Martin P Snead
PURPOSE: Despite posterior vitreous detachment being a common ocular event affecting most individuals in an aging population, there is little consensus regarding its precise anatomic definition. We investigated the morphologic appearance and molecular composition of the posterior hyaloid membrane to determine whether the structure clinically observed enveloping the posterior vitreous surface after posterior vitreous detachment is a true basement membrane and to postulate its origin. Understanding the relationship between the vitreous (in both its attached and detached state) and the internal limiting membrane of the retina is essential to understanding the cause of rhegmatogenous retinal detachment and vitreoretinal interface disorders, as well as potential future prophylactic and treatment strategies...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28867130/follow-up-to-age-4-years-of-treatment-of-type-1-retinopathy-of-prematurity-intravitreal-bevacizumab-injection-versus-laser-fluorescein-angiographic-findings
#11
Domenico Lepore, Graham E Quinn, Fernando Molle, Lorenzo Orazi, Antonio Baldascino, Marco H Ji, Maria Sammartino, Fabio Sbaraglia, Daniela Ricci, Eugenio Mercuri
PURPOSE: To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablation in type 1 retinopathy of prematurity (ROP). DESIGN: Single, randomized, controlled trial. PARTICIPANTS: All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. METHODS: In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28865878/will-perimetry-be-performed-to-monitor-glaucoma-in-2025
#12
Andrew S Camp, Robert N Weinreb
Visual field testing has played an essential role in the diagnosis and management of glaucoma for more than a century. Methods to examine the visual field have been refined from early kinetic perimetry to current standard automated perimetry (SAP). Clinicians now use SAP for the diagnosis and management of glaucoma throughout the world. Various testing paradigms and analytic methods have been developed to simplify the diagnosis of glaucoma and the interpretation of progression. Moreover, strategies have been implemented to improve patient experience with visual field testing and to increase reliability...
August 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28863943/the-effect-of-testing-reliability-on-visual-field-sensitivity-in-normal-eyes-the-singapore-chinese-eye-study
#13
Nicholas Y Q Tan, Yih-Chung Tham, Victor Koh, Duc Quang Nguyen, Carol Y Cheung, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: To quantitatively determine how the reliability indices in standard automated perimetry (SAP) affect the global indices of visual field (VF) results in nonglaucomatous eyes. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 830 adults aged 40 to 80 years, without visual impairment, glaucoma, significant cataract, and major eye diseases, were selected from the population-based Singapore Chinese Eye Study (SCES)...
August 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28847641/optical-coherence-tomography-predictors-of-risk-for-progression-to-non-neovascular-atrophic-age-related-macular-degeneration
#14
Karim Sleiman, Malini Veerappan, Katrina P Winter, Michelle N McCall, Glenn Yiu, Sina Farsiu, Emily Y Chew, Traci Clemons, Cynthia A Toth
PURPOSE: Appearance of geographic atrophy (GA) on color photography (CP) is preceded by specific features on spectral-domain optical coherence tomography (SD OCT). We aimed to build SD OCT-based risk assessment models for 5-year new onset of GA and central GA on CP. DESIGN: Prospective, longitudinal study. PARTICIPANTS: Age-Related Eye Disease Study 2 Ancillary SD OCT study participants with age-related macular degeneration (AMD) with bilateral large drusen or noncentral GA and at least 1 eye without advanced disease (n = 317)...
August 25, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28844323/idiopathic-acute-exudative-polymorphous-vitelliform-maculopathy-clinical-spectrum-and-multimodal-imaging-characteristics
#15
Irene Barbazetto, Kunal K Dansingani, Rosa Dolz-Marco, Alfonso Giovannini, F C Piccolino, Anita Agarwal, Lawrence A Yannuzzi
PURPOSE: To describe clinical findings in patients with acute exudative polymorphous vitelliform maculopathy (AEPVM). DESIGN: Retrospective, observational, multicenter case series review. PARTICIPANTS: Consecutive patients diagnosed with idiopathic AEPVM. METHODS: Review of clinical charts, multimodal imaging, electrophysiologic findings, and genetic findings in previously unpublished patients and review of the literature...
August 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28844322/incidence-risk-factors-and-outcomes-of-retinal-detachment-after-pediatric-cataract-surgery
#16
Sumita Agarkar, Varada Vinay Gokhale, Rajiv Raman, Muna Bhende, Gayathri Swaminathan, Mukesh Jain
PURPOSE: To report the incidence of, and to estimate the long-term risk and predisposing factors and the surgical outcomes for, retinal detachment (RD) after pediatric cataract surgery. DESIGN: Retrospective consecutive interventional case series. PARTICIPANTS: During the study period 1996 to 2007 at a tertiary eye care institute, 481 eyes of 295 children aged below 16 years with no other ocular and systemic anomalies who underwent lensectomy, posterior capsulorrhexis, and anterior vitrectomy combined with primary intraocular lens implantation were included...
August 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28827044/incidence-and-outcomes-of-repositioning-surgery-to-correct-misalignment-of-toric-intraocular-lenses
#17
Tetsuro Oshika, Mikio Inamura, Yasushi Inoue, Tsutomu Ohashi, Toru Sugita, Yoshifumi Fujita, Kazunori Miyata, Shinichiro Nakano
PURPOSE: To analyze the incidence and appropriate timing of repositioning surgery to correct misalignment of acrylic foldable toric intraocular lenses (IOLs). DESIGN: Retrospective, multicenter case series. PARTICIPANTS: Patients who had undergone phacoemulsification and implantation of toric IOL at 8 surgical sites. METHODS: Patient charts were reviewed to collect data on repositioning surgery of toric IOLs. MAIN OUTCOME MEASURES: Incidence, timing, and outcomes of repositioning surgery...
August 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28823399/uveal-melanoma-nuclear-brca1-associated-protein-1-immunoreactivity-is-an-indicator-of-metastasis
#18
Eszter Szalai, Jill R Wells, Laura Ward, Hans E Grossniklaus
PURPOSE: To examine the BRCA1-associated protein-1 (BAP1) expression of primary uveal melanomas without and with metastasis, and to analyze the correlation between the BAP1 immunoreactivity of primary uveal melanoma and other clinicopathologic features. DESIGN: Retrospective case series. PARTICIPANTS: Forty patients with uveal melanoma (mean age, 57.98±14.75 years) were included in this analysis, of whom 20 had no metastatic disease and 20 had metastasis...
August 17, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28823384/distinguishing-features-of-ocular-sarcoidosis-in-an-international-cohort-of-uveitis-patients
#19
Nisha R Acharya, Erica N Browne, Narsing Rao, Manabu Mochizuki
PURPOSE: To determine which clinical features distinguish ocular sarcoidosis from other forms of uveitis in an international population and to estimate the sensitivity and specificity of the International Workshop on Ocular Sarcoidosis (IWOS) clinical signs and laboratory tests. DESIGN: Multicenter, retrospective medical record review. PARTICIPANTS: Eight hundred eighty-four patients with uveitis from 19 centers in 12 countries. METHODS: Data collected included suspected cause of uveitis, clinical findings, and laboratory investigations within 6 months of presentation...
August 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28807636/visual-outcomes-and-complications-of-type-i-boston-keratoprosthesis-in-children-a-retrospective-multicenter-study-and-literature-review
#20
Simon S M Fung, Samir Jabbour, Mona Harissi-Dagher, Reginald R G Tan, Patrick Hamel, Kashif Baig, Asim Ali
PURPOSE: To report outcomes and complications of Boston type 1 keratoprosthesis (KPro) implantation in children. DESIGN: Retrospective, multicenter case series. PARTICIPANTS: All children 16 years of age or younger who underwent KPro surgery at 3 ophthalmology centers in Canada between January 2010 and November 2014. METHODS: Records of patients having undergone KPro implantation were reviewed. Data on preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes were collected and analyzed...
August 11, 2017: Ophthalmology
journal
journal
20208
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"