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Ophthalmology

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https://www.readbyqxmd.com/read/29779685/the-relationship-of-retinal-vessel-geometric-characteristics-to-the-incidence-and-progression-of-diabetic-retinopathy
#1
Ronald Klein, Kristine E Lee, Lorraine Danforth, Michael Y Tsai, Ronald E Gangnon, Stacy E Meuer, Tien Y Wong, Carol Y Cheung, Barbara E K Klein
PURPOSE: To examine the relationships of retinal vessel geometric characteristics (RVGCs) to the incidence and progression of diabetic retinopathy (DR). DESIGN: Observational, prospective cohort study. PARTICIPANTS: Nine hundred ninety-six persons with type 1 diabetes mellitus (T1DM) and 1370 persons with type 2 diabetes mellitus (T2DM) seen at a baseline examination who were eligible for follow-up examinations at subsequent 5-year intervals...
May 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29779684/improving-adult-amblyopic-vision-with-stereoscopic-3-dimensional-video-games
#2
Roger W Li, Kenneth D Tran, John K Bui, Michelle M Antonucci, Charlie V Ngo, Dennis M Levi
No abstract text is available yet for this article.
May 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29779683/strabismus-strabismus-surgery-and-reoperation-rate-in-the-united-states-analysis-from-the-iris-registry
#3
Michael X Repka, Flora Lum, Bhavya Burugapalli
PURPOSE: To describe the rates of strabismus, strabismus surgery, and strabismus surgery reoperations among all age groups in the United States. DESIGN: Retrospective analysis of electronic health record data. PARTICIPANTS: Patients from the IRIS (Intelligent Research in Sight) Registry. METHODS: Description of the types and rates of strabismus and strabismus surgery from 2013 to 2016 with subgroups by age, sex, race/ethnicity, and region of the United States...
May 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29776672/half-dose-photodynamic-therapy-versus-high-density-subthreshold-micropulse-laser-treatment-in-patients-with-chronic-central-serous-chorioretinopathy-the-place-trial
#4
Elon H C van Dijk, Sascha Fauser, Myrte B Breukink, Rocio Blanco-Garavito, Joannes M M Groenewoud, Jan E E Keunen, Petrus J H Peters, Greet Dijkman, Eric H Souied, Robert E MacLaren, Giuseppe Querques, Susan M Downes, Carel B Hoyng, Camiel J F Boon
PURPOSE: To compare the anatomic and functional efficacy and safety of half-dose photodynamic therapy (PDT) versus high-density subthreshold micropulse laser (HSML) treatment in patients with chronic central serous chorioretinopathy (cCSC). DESIGN: Open-label, multicenter, randomized controlled clinical trial. PARTICIPANTS: Patients with cCSC whose disease had to be confirmed by both clinical characteristics and findings on multimodal imaging...
May 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29776671/guidelines-on-diabetic-eye-care-the-international-council-of-ophthalmology-recommendations-for-screening-follow-up-referral-and-treatment-based-on-resource-settings
#5
REVIEW
Tien Y Wong, Jennifer Sun, Ryo Kawasaki, Paisan Ruamviboonsuk, Neeru Gupta, Van Charles Lansingh, Mauricio Maia, Wanjiku Mathenge, Sunil Moreker, Maji M K Muqit, Serge Resnikoff, Juan Verdaguer, Peiquan Zhao, Frederick Ferris, Lloyd P Aiello, Hugh R Taylor
Diabetes mellitus (DM) is a global epidemic and affects populations in both developing and developed countries, with differing health care and resource levels. Diabetic retinopathy (DR) is a major complication of DM and a leading cause of vision loss in working middle-aged adults. Vision loss from DR can be prevented with broad-level public health strategies, but these need to be tailored to a country's and population's resource setting. Designing DR screening programs, with appropriate and timely referral to facilities with trained eye care professionals, and using cost-effective treatment for vision-threatening levels of DR can prevent vision loss...
May 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29754993/topography-guided-lasik-versus-small-incision-lenticule-extraction-long-term-refractive-and-quality-of-vision-outcomes
#6
Anastasios John Kanellopoulos
No abstract text is available yet for this article.
May 10, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29753495/global-prevalence-of-presbyopia-and-vision-impairment-from-uncorrected-presbyopia-systematic-review-meta-analysis-and-modelling
#7
Timothy R Fricke, Nina Tahhan, Serge Resnikoff, Eric Papas, Anthea Burnett, Suit May Ho, Thomas Naduvilath, Kovin S Naidoo
TOPIC: Presbyopia prevalence and spectacle-correction coverage were estimated by systematic review and meta-analysis of epidemiologic evidence, then modeled to expand to country, region, and global estimates. CLINICAL RELEVANCE: Understanding presbyopia epidemiologic factors and correction coverage is critical to overcoming the burden of vision impairment (VI) from uncorrected presbyopia. METHODS: We performed systematic reviews of presbyopia prevalence and spectacle-correction coverage...
May 9, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29752001/efficacy-of-ranibizumab-in-eyes-with-diabetic-macular-edema-and-macular-nonperfusion-in-ride-and-rise
#8
Rahul K Reddy, Dante J Pieramici, Shamika Gune, Avanti Ghanekar, Na Lu, Carlos Quezada-Ruiz, Caroline R Baumal
PURPOSE: To determine whether there are baseline characteristics that distinguish patients with diabetic macular edema (DME) with coexisting macular nonperfusion (MNP) at baseline and assess these patients' potential to achieve favorable visual acuity (VA), anatomic, and diabetic retinopathy (DR) outcomes over 24 months. DESIGN: Post hoc analysis of RIDE/RISE, 2 phase 3, parallel, randomized, multicenter, double-masked trials (ClinicalTrials.gov: NCT00473382; NCT00473330)...
May 8, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29759820/clustered-regularly-interspaced-short-palindromic-repeats-based-genome-surgery-for-the-treatment-of-autosomal-dominant-retinitis-pigmentosa
#9
Yi-Ting Tsai, Wen-Hsuan Wu, Ting-Ting Lee, Wei-Pu Wu, Christine L Xu, Karen S Park, Xuan Cui, Sally Justus, Chyuan-Sheng Lin, Ruben Jauregui, Pei-Yin Su, Stephen H Tsang
PURPOSE: To develop a universal gene therapy to overcome the genetic heterogeneity in retinitis pigmentosa (RP) resulting from mutations in rhodopsin (RHO). DESIGN: Experimental study for a combination gene therapy that uses both gene ablation and gene replacement. PARTICIPANTS: This study included 2 kinds of human RHO mutation knock-in mouse models: RhoP23H and RhoD190N . In total, 23 RhoP23H/P23H , 43 RhoP23H/+ , and 31 RhoD190N/+ mice were used for analysis...
May 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29739629/phenotypic-characteristics-of-a-french-cohort-of-patients-with-x-linked-retinoschisis
#10
Raphaëlle Orès, Saddek Mohand-Said, Claire-Marie Dhaenens, Aline Antonio, Christina Zeitz, Edouard Augstburger, Camille Andrieu, José-Alain Sahel, Isabelle Audo
PURPOSE: To analyze the retinal structure in patients with X-linked retinoschisis (XLRS) using spectral-domain OCT and to correlate the morphologic findings with visual acuity, electroretinographic results, and patient age. DESIGN: Retrospective, observational study. PARTICIPANTS: Data from 52 consecutive male patients with molecularly confirmed XLRS were collected retrospectively. METHODS: Complete clinical evaluation included best-corrected visual acuity, full-field electroretinography, fundus photography, spectral-domain OCT, and fundus autofluorescence...
May 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29739628/collagen-cross-linked-therapeutic-grafts-in-fungal-keratitis
#11
Jeewan S Titiyal, Anjana Karunakaran, Manpreet Kaur, Anubha Rathi, Tushar Agarwal, Namrata Sharma
No abstract text is available yet for this article.
May 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29731147/five-year-graft-survival-of-descemet-membrane-endothelial-keratoplasty-ek-versus-descemet-stripping-ek-and-the-effect-of-donor-sex-matching
#12
David A Price, Meagan Kelley, Francis W Price, Marianne O Price
PURPOSE: To determine whether the reduced risk of immunologic rejection with Descemet membrane endothelial keratoplasty (DMEK) results in a 5-year survival advantage relative to Descemet stripping endothelial keratoplasty (DSEK) and to determine whether matching the donor and recipient sex affects the rejection episode and graft survival rates. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients with Fuchs' endothelial corneal dystrophy treated with DSEK or DMEK...
May 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29729809/retinopathy-regression-with-treat-and-extend-ranibizumab-for-diabetic-macular-edema
#13
John F Payne, W Lloyd Clark, Beau B Bruce, Charles C Wykoff, David M Brown, Brandon M Menke, Shawn M Iverson, Keri F Allen, David S Boyer
No abstract text is available yet for this article.
May 2, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716788/aquaporin-4-and-myelin-oligodendrocyte-glycoprotein-autoantibody-status-predict-outcome-of-recurrent-optic-neuritis
#14
Jiraporn Jitprapaikulsan, John J Chen, Eoin P Flanagan, W Oliver Tobin, Jim P Fryer, Brian G Weinshenker, Andrew McKeon, Vanda A Lennon, Jacqueline A Leavitt, Jan-Mendelt Tillema, Claudia Lucchinetti, B Mark Keegan, Orhun Kantarci, Cheryl Khanna, Sarah M Jenkins, Grant M Spears, Jessica Sagan, Sean J Pittock
PURPOSE: To determine the aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG) serostatus and visual outcomes in patients with recurrent optic neuritis (rON) initially seeking treatment. DESIGN: Cross-sectional cohort study. PARTICIPANTS: The study identified patients by searching the Mayo Clinic computerized central diagnostic index (January 2000-March 2017). The 246 eligible patients fulfilled the following criteria: (1) initially seeking treatment for at least 2 consecutive episodes of optic neuritis (ON) and (2) serum available for testing...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716787/management-of-acute-retinal-ischemia-follow-the-guidelines
#15
REVIEW
Valérie Biousse, Fadi Nahab, Nancy J Newman
Acute retinal arterial ischemia, including vascular transient monocular vision loss (TMVL) and branch (BRAO) and central retinal arterial occlusions (CRAO), are ocular and systemic emergencies requiring immediate diagnosis and treatment. Guidelines recommend the combination of urgent brain magnetic resonance imaging with diffusion-weighted imaging, vascular imaging, and clinical assessment to identify TMVL, BRAO, and CRAO patients at highest risk for recurrent stroke, facilitating early preventive treatments to reduce the risk of subsequent stroke and cardiovascular events...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716786/systemic-and-ocular-determinants-of-peripapillary-retinal-nerve-fiber-layer-thickness-measurements-in-the-european-eye-epidemiology-e3-population
#16
Matthias M Mauschitz, Pieter W M Bonnemaijer, Kersten Diers, Franziska G Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M Arfan Ikram, Johannes R Vingerling, Katie M Williams, Christopher J Hammond, Catherine Creuzot-Garcher, Alain M Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G Holz, Caroline C W Klaver, Monique M B Breteler, Robert P Finger
PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716785/hyperopic-trend-after-cataract-surgery-in-eyes-with-fuchs-endothelial-corneal-dystrophy
#17
Katrin Wacker, Lilian C B Cavalcante, Keith H Baratz, Sanjay V Patel
No abstract text is available yet for this article.
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716784/emixustat-hydrochloride-for-geographic-atrophy-secondary-to-age-related-macular-degeneration-a-randomized-clinical-trial
#18
Philip J Rosenfeld, Pravin U Dugel, Frank G Holz, Jeffrey S Heier, Joel A Pearlman, Roger L Novack, Karl G Csaky, John M Koester, Jeffrey K Gregory, Ryo Kubota
PURPOSE: To determine whether emixustat hydrochloride (emixustat) reduces the rate of enlargement of geographic atrophy (GA) compared with placebo in subjects with age-related macular degeneration (AMD) and to evaluate the safety and tolerability of emixustat over 24 months of treatment. DESIGN: Multicenter, randomized, double-masked, placebo-controlled, phase 2b/3 clinical trial. PARTICIPANTS: Patients with GA secondary to AMD, a visual acuity score of at least 35 letters, and GA with a total area of 1...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29716783/ultrawide-field-oct-to-investigate-relationships-between-myopic-macular-retinoschisis-and-posterior-staphyloma
#19
Kosei Shinohara, Noriko Tanaka, Jost B Jonas, Noriaki Shimada, Muka Moriyama, Takeshi Yoshida, Kyoko Ohno-Matsui
PURPOSE: To investigate the relationships between myopic macular retinoschisis (MRS) and posterior staphylomas and to reveal the characteristics of other retinal lesions associated with MRS. DESIGN: Retrospective, observational case series. PARTICIPANTS: Seven hundred twenty-nine eyes of 420 patients with high myopia, which was defined as myopic refractive error of more than -8.0 diopters or an axial length longer than 26.5 mm. METHODS: Highly myopic eyes were examined by ultrawide-field (UWF) swept-source (SS) OCT with scan width of up to 23 mm and scan depth of 5 mm...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29706360/whole-exome-sequencing-in-age-related-macular-degeneration-identifies-rare-variants-in-col8a1-a-component-of-bruch-s-membrane
#20
Jordi Corominas, Johanna M Colijn, Maartje J Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A M Verlouw, Jeroen G J van Rooij, Robert Kraaij, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Tina Schick, Sascha Fauser, Eiko K de Jong, Cornelia M van Duijn, Carel B Hoyng, Caroline C W Klaver, Anneke I den Hollander
PURPOSE: Genome-wide association studies and targeted sequencing studies of candidate genes have identified common and rare variants that are associated with age-related macular degeneration (AMD). Whole-exome sequencing (WES) studies allow a more comprehensive analysis of rare coding variants across all genes of the genome and will contribute to a better understanding of the underlying disease mechanisms. To date, the number of WES studies in AMD case-control cohorts remains scarce and sample sizes are limited...
April 26, 2018: Ophthalmology
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