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Ophthalmology

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https://www.readbyqxmd.com/read/28318637/impact-of-multiple-en-face-image-averaging-on-quantitative-assessment-from-optical-coherence-tomography-angiography-images
#1
Akihito Uji, Siva Balasubramanian, Jianqin Lei, Elmira Baghdasaryan, Mayss Al-Sheikh, SriniVas R Sadda
PURPOSE: To investigate the impact of multiple en face image averaging on quantitative measurements of the retinal microvasculature using optical coherence tomography angiography (OCTA). DESIGN: Prospective, observational, cross-sectional case series. PARTICIPANTS: Twenty-one healthy individuals with normal eyes. METHODS: Macular OCTA images were acquired from all participants using the Zeiss Cirrus 5000 with Angioplex OCTA software (Carl Zeiss Meditec, Dublin, CA)...
March 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318635/the-application-of-infrared-imaging-and-optical-coherence-tomography-of-the-lacrimal-punctum-in-patients-undergoing-punctoplasty-for-epiphora
#2
Hannah M Timlin, Pearse A Keane, Geoffrey E Rose, Daniel G Ezra
PURPOSE: To determine the application of imaging the stenotic lacrimal punctum with infrared photographs and optical coherence tomography (OCT) and to identify characteristics of the lacrimal punctum in patients who benefit from punctoplasty. DESIGN: Case-control study. PARTICIPANTS: Twenty patients with epiphora who were listed for punctoplasty and 20 healthy controls. METHODS: Prospectively, 20 patients listed for punctoplasty were asked to rate their epiphora, using the Munk score, before and after punctoplasty...
March 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318640/the-prevalence-of-diabetic-retinopathy-in-australian-adults-with-self-reported-diabetes-the-national-eye-health-survey
#3
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. METHODS: Diabetes was determined based on self-report of previous diagnosis of the disease...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318639/enhancement-after-small-incision-lenticule-extraction-incidence-risk-factors-and-outcomes
#4
Yu-Chi Liu, Mohamad Rosman, Jodhbir S Mehta
PURPOSE: To report the incidence, risk factors, and outcomes of enhancement after small-incision lenticule extraction (SMILE). DESIGN: Retrospective cohort study. PARTICIPANTS: Five hundred twenty-four eyes of 307 patients who underwent SMILE at Singapore National Eye Center between February 2012 and March 2016. METHODS: The data collected included patient age at primary SMILE, gender, race, preoperative and postoperative manifest refraction spherical equivalent (MRSE), preoperative and postoperative uncorrected distance visual acuity and corrected distance visual acuity, the occurrence of suction loss during the procedure, and the need for enhancement...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318638/optical-coherence-tomography-guided-decisions-in-retinoblastoma-management
#5
Sameh E Soliman, Cynthia VandenHoven, Leslie D MacKeen, Elise Héon, Brenda L Gallie
PURPOSE: Assess the role of handheld optical coherence tomography (OCT) in guiding management decisions during diagnosis, treatment, and follow-up of eyes affected by retinoblastoma. DESIGN: Retrospective, noncomparative, single-institution case series. PARTICIPANTS: All children newly diagnosed with retinoblastoma from January 2011 to December 2015 who had an OCT session during their active treatment at The Hospital for Sick Children (SickKids) in Toronto, Canada...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28318636/peripheral-laser-for-recalcitrant-macular-edema-owing-to-retinal-vein-occlusion-the-wave-trial
#6
Charles C Wykoff, William C Ou, Rui Wang, David M Brown, Cassandra Cone, Deneva Zamora, Ryan T Le, Min Sagong, Kang Wang, SriniVas R Sadda
No abstract text is available yet for this article.
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28302322/high-risk-histopathology-features-in-primary-and-secondary-enucleated-international-intraocular-retinoblastoma-classification-group-d-eyes
#7
Ido D Fabian, Andrew W Stacey, Tanzina Chowdhury, Catriona Duncan, Esin K Karaa, Irene Scheimberg, M Ashwin Reddy, Mandeep S Sagoo
PURPOSE: To evaluate the rate and identify the risk factors for high-risk histopathologic features in group D retinoblastoma eyes enucleated as primary or secondary treatment. DESIGN: Retrospective analysis. PARTICIPANTS: A total of 64 enucleated group D eyes (62 patients), of which 40 (40 patients) were primary and 24 (22 patients) were secondary to other treatments. METHODS: Clinicopathologic correlation of consecutive group D eyes enucleated from 2002 to 2014...
March 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28284786/serial-spectral-domain-optical-coherence-tomography-findings-in-acute-retinal-pigment-epitheliitis-and-the-correlation-to-visual-acuity
#8
Lawrence P L Iu, Rachel Lee, Michelle C Y Fan, Wai-Ching Lam, Robert T Chang, Ian Y H Wong
PURPOSE: To evaluate the features of acute retinal pigment epitheliitis (ARPE) at onset and in the course of recovery by serial spectral-domain optical coherence tomography (SD OCT) and the correlation to visual acuity (VA). DESIGN: Retrospective cohort study. PARTICIPANTS: Consecutive patients with ARPE. METHODS: A review of medical records was performed. MAIN OUTCOME MEASURES: Integrity of SD OCT retinal bands at onset and in the course of disease, time required to achieve each retinal band restoration, corresponding VA change, and final VA...
March 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28284785/the-clinical-importance-of-changes-in-diabetic-retinopathy-severity-score
#9
Michael S Ip, Jiameng Zhang, Jason S Ehrlich
PURPOSE: To investigate the clinical importance of changes in diabetic retinopathy severity score (DRSS) in patients with diabetic macular edema (DME) treated with intravitreal ranibizumab. DESIGN: Post hoc analysis of the phase III RIDE and RISE studies of ranibizumab for treatment of DME. PARTICIPANTS: Four hundred sixty-eight eyes treated with ranibizumab from randomization with gradable DRSS on baseline fundus photographs. METHODS: Visual and anatomic outcomes were examined in eyes grouped according to DRSS change from baseline to month 24...
March 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28283281/trends-in-vitreoretinal-procedures-for-medicare-beneficiaries-2000-to-2014
#10
Michael D McLaughlin, John C Hwang
TOPIC: The purpose of this study was to identify changes in use for vitreoretinal procedures by measuring the number of allowed services using data from the US Medicare Part B Fee-for-Service (FFS) beneficiaries and their providers. CLINICAL RELEVANCE: To analyze vitreoretinal procedural trends, which may indicate standard of care and importance of developing methods of treatments. METHODS: Medicare Part B National Summary Data Files for calendar years 2000 to 2014 were used to identify the number of allowed services for vitreoretinal procedures and commonly used pharmacologic agents...
March 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28283280/foveal-hypoplasia-in-patients-with-stickler-syndrome
#11
Itsuka Matsushita, Tatsuo Nagata, Takaaki Hayashi, Kenichi Kimoto, Toshiaki Kubota, Masahito Ohji, Shunji Kusaka, Hiroyuki Kondo
PURPOSE: To determine the microstructure of the fovea in patients with Stickler syndrome using imaging by spectral-domain optical coherence tomography (SD OCT) and swept-source OCT. DESIGN: Retrospective case series study. PARTICIPANTS: A total of 39 eyes of 25 patients with genetically confirmed Stickler syndrome were studied. METHODS: All of the patients had mutations in the COL2A1 gene and were diagnosed with Stickler syndrome...
March 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28283279/randomized-controlled-trial-comparing-transepithelial-corneal-cross-linking-using-iontophoresis-with-the-dresden-protocol-in-progressive-keratoconus
#12
Marco Lombardo, Daniela Giannini, Giuseppe Lombardo, Sebastiano Serrao
PURPOSE: To compare clinical outcomes of transepithelial corneal cross-linking using iontophoresis (T-ionto CL) and standard corneal cross-linking (standard CL) for the treatment of progressive keratoconus 12 months after the operation. DESIGN: Prospective randomized controlled clinical trial. PARTICIPANTS: Thirty-four eyes of 25 participants with progressive keratoconus were randomized into T-ionto CL (22 eyes) or standard CL (12 eyes). METHODS: T-ionto CL was performed using an iontophoresis device with dextran-free 0...
March 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28268099/frequency-of-testing-to-detect-visual-field-progression-derived-using-a-longitudinal-cohort-of-glaucoma-patients
#13
Zhichao Wu, Luke J Saunders, Fábio B Daga, Alberto Diniz-Filho, Felipe A Medeiros
PURPOSE: To determine the time required to detect statistically significant progression for different rates of visual field loss using standard automated perimetry (SAP) when considering different frequencies of testing using a follow-up scheme that resembles clinical practice. DESIGN: Observational cohort study. PARTICIPANTS: One thousand seventy-two eyes of 665 patients with glaucoma followed up over an average of 4.3±0.9 years. METHODS: Participants with 5 or more visual field tests over a 2- to 5-year period were included to derive the longitudinal measurement variability of SAP mean deviation (MD) using linear regressions...
March 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28268098/nepafenac-0-3-after-cataract-surgery-in-patients-with-diabetic-retinopathy-results-of-2-randomized-phase-3-studies
#14
Rishi P Singh, Robert Lehmann, Joseph Martel, Kevin Jong, Ayala Pollack, Alexis Tsorbatzoglou, Giovanni Staurenghi, Guadalupe Cervantes-Coste Cervantes, Louis Alpern, Satish Modi, Liza Svoboda, Adeniyi Adewale, Glenn J Jaffe
PURPOSE: To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes. DESIGN: Two prospective, randomized, multicenter, double-masked, vehicle-controlled phase 3 studies. PARTICIPANTS: Total, 615 patients in study 1 and 605 patients in study 2. METHODS: Patients were randomized (1:1) to topical nepafenac 0...
March 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28238457/intraoperative-findings-in-consecutive-exotropia-with-and-without-adduction-deficit
#15
Sarah R Hatt, David A Leske, Jae Ho Jung, Jonathan M Holmes
PURPOSE: Consecutive exotropia may be associated with limited adduction, which has been reported to be caused by 1 or more anatomic abnormalities of rectus muscles or their insertions. We studied the relative frequency of grades of adduction deficit and the relative frequency of abnormal anatomic findings. DESIGN: Retrospective cohort study. PARTICIPANTS: Patients undergoing surgery for consecutive exotropia. METHODS: Preoperative duction deficits were graded on a -5 (severe limitation) to 0 (normal) scale...
February 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28237428/slow-release-dexamethasone-in-proliferative-vitreoretinopathy-a-prospective-randomized-controlled-clinical-trial
#16
Philip J Banerjee, Ana Quartilho, Catey Bunce, Wen Xing, Tapiwa M Zvobgo, Nicola Harris, David G Charteris
PURPOSE: To test the hypothesis that adjunctive slow-release dexamethasone implant (Ozurdex; Allergan Inc, Irvine, CA) can improve the outcomes of vitreoretinal surgery for established proliferative vitreoretinopathy (PVR). DESIGN: A 2-year, single-center, prospective, participant- and surgeon-masked randomized controlled clinical trial (EudraCT No. 2011-004498-96). PARTICIPANTS: A total of 140 patients requiring vitrectomy surgery with silicone oil for retinal detachment with established PVR (Grade C) were randomized to standard (control) or study treatment (adjunct) in a 1:1 allocation ratio...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28237427/three-dimensional-eye-shape-myopic-maculopathy-and-visual-acuity-the-zhongshan-ophthalmic-center-brien-holden-vision-institute-high-myopia-cohort-study
#17
Xinxing Guo, Ou Xiao, Yanxian Chen, Huawang Wu, Linxing Chen, Ian G Morgan, Mingguang He
PURPOSE: To investigate the relationship among eye shape, myopic maculopathy, and visual acuity in highly myopic eyes using 3-dimensional (3D) magnetic resonance imaging (MRI). DESIGN: Observational case series. PARTICIPANTS: The study included 190 eyes of 95 participants with bilateral high myopia from the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Cohort Study, with spherical power ≤-6.00 diopters (D) in both eyes...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28237426/the-role-of-the-human-visual-cortex-in-assessment-of-the-long-term-durability-of-retinal-gene-therapy-in-follow-on-rpe65-clinical-trial-patients
#18
Manzar Ashtari, Elena S Nikonova, Kathleen A Marshall, Gloria J Young, Puya Aravand, Wei Pan, Gui-Shuang Ying, Aimee E Willett, Mani Mahmoudian, Albert M Maguire, Jean Bennett
PURPOSE: Gene therapy (GT) has offered immense hope to individuals who are visually impaired because of RPE65 mutations. Although GT has shown great success in clinical trials enrolling these individuals, evidence for stability and durability of this treatment over time is still unknown. Herein we explored the value of functional magnetic resonance imaging (fMRI) as an objective measure to assess independently the longevity of retinal GT. DESIGN: Individuals with RPE65 mutations who underwent GT in their worse-seeing eye in a phase 1 clinical trial received a second subretinal injection in their contralateral eye in a follow-on clinical trial...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28237425/aqueous-angiography-in-living-nonhuman-primates-shows-segmental-pulsatile-and-dynamic-angiographic-aqueous-humor-outflow
#19
Alex S Huang, Meng Li, Diya Yang, Huaizhou Wang, Ningli Wang, Robert N Weinreb
PURPOSE: To evaluate the feasibility of safely performing aqueous angiography in intact eyes of living nonhuman primates (NHPs) for evaluating aqueous humor outflow and segmental patterns. DESIGN: Cross-sectional, observational study. SUBJECTS: Six nonhuman primates. METHODS: Aqueous angiography was performed in 6 nonhuman primates. After anesthesia, an anterior chamber (AC) maintainer was placed through a temporal 1-mm side-port wound...
February 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28215452/myopic-shift-5-years-after-intraocular-lens-implantation-in-the-infant-aphakia-treatment-study
#20
David R Weakley, Michael J Lynn, Lindreth Dubois, George Cotsonis, M Edward Wilson, Edward G Buckley, David A Plager, Scott R Lambert
PURPOSE: To report the myopic shift at 5 years of age after cataract surgery with intraocular lens (IOL) implantation for infants enrolled in the Infant Aphakia Treatment Study (IATS). METHODS: Refractions were performed at 1 month and every 3 months postoperatively until age 4 years and then at ages 4.25, 4.5, and 5 years. The change in refraction over time was estimated by linear mixed model analysis. RESULTS: Intraocular lens implantation was completed in 56 eyes; 43 were analyzed (median age, 2...
February 16, 2017: Ophthalmology
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