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Ophthalmology

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https://www.readbyqxmd.com/read/29331556/polypoidal-choroidal-vasculopathy-definition-pathogenesis-diagnosis-and-management
#1
REVIEW
Chui Ming Gemmy Cheung, Timothy Y Y Lai, Paisan Ruamviboonsuk, Shih-Jen Chen, Youxin Chen, K Bailey Freund, Fomi Gomi, Adrian H Koh, Won-Ki Lee, Tien Yin Wong
Polypoidal choroidal vasculopathy (PCV) is an age-related macular degeneration (AMD) subtype and is seen particularly in Asians. Previous studies have suggested disparity in response to intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents between PCV and typical AMD, and thus, the preferred treatment for PCV has remained unclear. Recent research has provided novel insights into the pathogenesis of PCV, and imaging studies based on OCT suggest that PCV belongs to a spectrum of conditions characterized by pachychoroid, in which disturbance in the choroidal circulation seems to be central to its pathogenesis...
January 10, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310965/evaluation-of-primary-angle-closure-glaucoma-susceptibility-loci-in-patients-with-early-stages-of-angle-closure-disease
#2
Monisha E Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T Wong, Shamira Perera, Tien Yin Wong, Subbiah R Krishnadas, Periasamy Sundaresan, Tin Aung, Eranga N Vithana
PURPOSE: To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). DESIGN: Case-control study. PARTICIPANTS: A total of 1397 PACS patients and 943 controls of Chinese ethnicity from Singapore and 604 PACS patients and 287 controls of Indian ethnicity. METHODS: The 8 PACG single nucleotide polymorphisms (SNPs; rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310964/early-patterns-of-macular-degeneration-in-abca4-associated-retinopathy
#3
Kamron N Khan, Melissa Kasilian, Omar A R Mahroo, Preena Tanna, Angelos Kalitzeos, Anthony G Robson, Kazushige Tsunoda, Takeshi Iwata, Anthony T Moore, Kaoru Fujinami, Michel Michaelides
PURPOSE: To describe the earliest features of ABCA4-associated retinopathy. DESIGN: Case series. PARTICIPANTS: Children with a clinical and molecular diagnosis of ABCA4-associated retinopathy without evidence of macular atrophy. METHODS: The retinal phenotype was characterized by color fundus photography, OCT, fundus autofluorescence (FAF) imaging, electroretinography, and in 2 patients, adaptive optics scanning laser ophthalmoscopy (AOSLO)...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310963/guidance-on-noncorticosteroid-systemic-immunomodulatory-therapy-in-noninfectious-uveitis-fundamentals-of-care-for-uveitis-focus-initiative
#4
REVIEW
Andrew D Dick, James T Rosenbaum, Hassan A Al-Dhibi, Rubens Belfort, Antoine P Brézin, Soon Phaik Chee, Janet L Davis, Athimalaipet V Ramanan, Koh-Hei Sonoda, Ester Carreño, Heloisa Nascimento, Sawsen Salah, Sherveen Salek, Jay Siak, Laura Steeples
TOPIC: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. CLINICAL RELEVANCE: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. METHODS: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic review of the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE, CINAHL, SCOPUS, BIOSIS, and Web of Science)...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310962/glaucomatous-optic-neuropathy-associated-with-nocturnal-dip-in-blood-pressure-findings-from-the-maracaibo-aging-study
#5
Jesús D Melgarejo, Joseph H Lee, Michele Petitto, Juan B Yépez, Felipe A Murati, Zhezhen Jin, Carlos A Chávez, Rosa V Pirela, Gustavo E Calmón, Winston Lee, Matthew P Johnson, Luis J Mena, Lama A Al-Aswad, Joseph D Terwilliger, Rando Allikmets, Gladys E Maestre, C Gustavo De Moraes
PURPOSE: To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. DESIGN: Observational cross-sectional study. PARTICIPANTS: A subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure <22 mmHg...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29306552/nationwide-prevalence-of-self-reported-serious-sensory-impairments-and-their-associations-with-self-reported-cognitive-and-functional-difficulties
#6
Spencer D Fuller, Lucy I Mudie, Carlos Siordia, Bonnielin K Swenor, David S Friedman
PURPOSE: To estimate the nationwide prevalence of self-reported serious vision impairment (SVI), serious hearing impairment (SHI), and serious dual sensory impairment (DSI; i.e., concomitant SVI and SHI) and to characterize their associations with self-reported cognitive, independent living, self-care, and ambulatory difficulties. DESIGN: The American Community Survey (ACS) is a nationwide cross-sectional survey administered by the United States Census Bureau. PARTICIPANTS: The 2011-2015 ACS sample contains data on 7 210 535 individuals 45 years of age or older...
January 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29276052/nonsyndromic-retinitis-pigmentosa-in-the-ashkenazi-jewish-population-genetic-and-clinical-aspects
#7
Adva Kimchi, Samer Khateb, Rong Wen, Ziqiang Guan, Alexey Obolensky, Avigail Beryozkin, Shoshi Kurtzman, Anat Blumenfeld, Eran Pras, Samuel G Jacobson, Tamar Ben-Yosef, Hadas Newman, Dror Sharon, Eyal Banin
PURPOSE: To analyze the genetic and clinical findings in retinitis pigmentosa (RP) patients of Ashkenazi Jewish (AJ) descent, aiming to identify genotype-phenotype correlations. DESIGN: Cohort study. PARTICIPANTS: Retinitis pigmentosa patients from 230 families of AJ origin. METHODS: Sanger sequencing was performed to detect specific founder mutations known to be prevalent in the AJ population. Ophthalmologic analysis included a comprehensive clinical examination, visual acuity (VA), visual fields, electroretinography, color vision testing, and retinal imaging by OCT, pseudocolor, and autofluorescence fundus photography...
December 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29249265/topical-cidofovir-for-treatment-refractory-ocular-surface-squamous-neoplasia
#8
Matthew H Ip, C R Robert George, Zin Naing, Elliot M Perlman, William Rawlinson, Minas T Coroneo
No abstract text is available yet for this article.
December 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29248173/the-primary-tube-versus-trabeculectomy-study-methodology-of-a-multicenter-randomized-clinical-trial-comparing-tube-shunt-surgery-and-trabeculectomy-with-mitomycin-c
#9
Steven J Gedde, Philip P Chen, Dale K Heuer, Kuldev Singh, Martha M Wright, William J Feuer, Joyce C Schiffman, Wei Shi
PURPOSE: To describe the methodology of the Primary Tube Versus Trabeculectomy (PTVT) Study. DESIGN: Multicenter randomized clinical trial. PARTICIPANTS: Patients with medically uncontrolled glaucoma and no prior incisional ocular surgery. METHODS: Patients are being enrolled at 16 clinical centers and randomly assigned to treatment with a tube shunt (350-mm2 Baerveldt glaucoma implant) or trabeculectomy with mitomycin C (0...
December 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29241744/fragility-of-results-in-ophthalmology-randomized-controlled-trials-a-systematic-review
#10
REVIEW
Carl Shen, Isabel Shamsudeen, Forough Farrokhyar, Kourosh Sabri
PURPOSE: Evidence-based medicine is guided by our interpretation of randomized controlled trials (RCTs) that address important clinical questions. Evaluation of the robustness of statistically significant outcomes adds a crucial element to the global assessment of trial findings. The purpose of this systematic review was to determine the robustness of ophthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness of statistically significant outcomes...
December 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29241743/glaucoma-after-lens-sparing-vitrectomy-for-advanced-retinopathy-of-prematurity
#11
Eric Nudleman, Ilkay Kilic Muftuoglu, Raouf Gaber, Joshua Robinson, Kimberly Drenser, Antonio Capone, Michael T Trese
PURPOSE: To report the incidence of, and factors related to, glaucoma after lens-sparing vitrectomy (LSV) surgery in advanced retinopathy of prematurity (ROP). DESIGN: Retrospective case series at a single tertiary referral pediatric vitreoretinal practice. PARTICIPANTS: Four hundred and one eyes from 270 patients were included. METHODS: The medical records of patients who underwent LSV for stage 4A, 4B, and 5 ROP were retrospectively reviewed...
December 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29224926/fully-automated-detection-and-quantification-of-macular-fluid-in-oct-using-deep-learning
#12
Thomas Schlegl, Sebastian M Waldstein, Hrvoje Bogunovic, Franz Endstraßer, Amir Sadeghipour, Ana-Maria Philip, Dominika Podkowinski, Bianca S Gerendas, Georg Langs, Ursula Schmidt-Erfurth
PURPOSE: Development and validation of a fully automated method to detect and quantify macular fluid in conventional OCT images. DESIGN: Development of a diagnostic modality. PARTICIPANTS: The clinical dataset for fluid detection consisted of 1200 OCT volumes of patients with neovascular age-related macular degeneration (AMD, n = 400), diabetic macular edema (DME, n = 400), or retinal vein occlusion (RVO, n = 400) acquired with Zeiss Cirrus (Carl Zeiss Meditec, Dublin, CA) (n = 600) or Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) (n = 600) OCT devices...
December 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29224928/association-of-rare-predicted-loss-of-function-variants-in-cellular-pathways-with-sub-phenotypes-in-age-related-macular-degeneration
#13
Alexandra Pietraszkiewicz, Freekje van Asten, Alan Kwong, Rinki Ratnapriya, Goncalo Abecasis, Anand Swaroop, Emily Y Chew
PURPOSE: To investigate the association of rare predicted loss-of-function (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes. DESIGN: Case-control study. PARTICIPANTS: Participants of AREDS, AREDS2, and Michigan Genomics Initiative. METHODS: Whole genome sequencing data were analyzed for rare pLoF variants (frequency <0.1%) in the regions of previously identified 52 independent risk variants known to be associated with AMD...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29224927/central-visual-field-damage-and-parapapillary-choroidal-microvasculature-dropout-in-primary-open-angle-glaucoma
#14
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
PURPOSE: To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: Thirty-two POAG patients with an initial parafoveal scotoma (IPFS) within a 10° radius in 1 hemifield and 42 POAG patients with an initial nasal step (INS) within the nasal periphery outside 10° of fixation in 1 hemifield...
December 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29217149/mucous-membrane-pemphigoid-with-ocular-involvement-the-clinical-phenotype-and-its-relationship-to-direct-immunofluorescence-findings
#15
Hon Shing Ong, Jane F Setterfield, Darwin C Minassian, John K Dart
PURPOSE: This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29217148/ethnic-differences-in-the-prevalence-and-risk-factors-of-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#16
Gavin S Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L Lamoureux, Ching-Yu Cheng, Tien Y Wong
PURPOSE: To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons of Malay, Indian, and Chinese ethnicity aged 40+ years, living in Singapore. METHODS: Diabetes was defined as nonfasting plasma glucose ≥200 mg/dl (11.1 mmol/l), glycated hemoglobin A1c (HbA1c) >6.5%, self-reported physician-diagnosed diabetes, or the use of glucose-lowering medication...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29217147/a-study-of-the-natural-history-of-vitreomacular-traction-syndrome-by-oct
#17
Marie-Hélène Errera, Sidath E Liyanage, Petros Petrou, Pearse A Keane, Rene Moya, Eric Ezra, David G Charteris, Louisa Wickham
PURPOSE: To examine the natural history of vitreomacular traction syndrome (VMTS) in the absence of other ocular comorbidities. DESIGN: Retrospective clinical case series. PARTICIPANTS: A total of 183 eyes of 159 patients diagnosed with VMTS with no other ocular comorbidity. METHODS: Patients with VMTS were identified from an OCT database at Moorfields Eye Hospital, London. Sequential OCT scans and patient notes were reviewed over a minimum period of 6 months...
December 4, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29208450/intracameral-chemotherapy-for-globe-salvage-in-retinoblastoma-with-secondary-anterior-chamber-invasion
#18
Francis L Munier, Alexandre Moulin, Marie-Claire Gaillard, Massimo Bongiovanni, Sarah Decembrini, Susan Houghton, Maja Beck-Popovic, Christina Stathopoulos
No abstract text is available yet for this article.
December 2, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29203068/prospective-randomized-trial-of-corneal-cross-linking-riboflavin-dosing-frequencies-for-treatment-of-keratoconus-and-corneal-ectasia
#19
Marianne O Price, Kelly Fairchild, Matthew T Feng, Francis W Price
PURPOSE: To investigate whether the riboflavin dosing frequency affects corneal cross-linking efficacy or safety, given that isotonic riboflavin solution is viscous and each installation coats the corneal surface with a film that absorbs some of the incident ultraviolet A light. DESIGN: Prospective, randomized, single-center equivalence trial. PARTICIPANTS: Patients with progressive keratoconus or ectasia after refractive surgery (n = 510)...
December 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29203067/personalized-prediction-of-glaucoma-progression-under-different-target-intraocular-pressure-levels-using-filtered-forecasting-methods
#20
Pooyan Kazemian, Mariel S Lavieri, Mark P Van Oyen, Chris Andrews, Joshua D Stein
PURPOSE: To generate personalized forecasts of how patients with open-angle glaucoma (OAG) experience disease progression at different intraocular pressure (IOP) levels to aid clinicians with setting personalized target IOPs. DESIGN: Secondary analyses using longitudinal data from 2 randomized controlled trials. PARTICIPANTS: Participants with moderate or advanced OAG from the Collaborative Initial Glaucoma Treatment Study (CIGTS) or the Advanced Glaucoma Intervention Study (AGIS)...
December 1, 2017: Ophthalmology
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