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Marco Zarbin, Min Tsuboi, Lauren F Hill, Ivaylo Stoilov
OBJECTIVE: A simulated switching study assessed the effects of continuing the same anti-vascular endothelial growth factor (VEGF) treatment among patients who are typically considered for a therapy switch. Post hoc analysis of data from HARBOR (NCT00891735) was undertaken. Patients with neovascular age-related macular degeneration who demonstrated a suboptimal response after 3 or 6 months of ranibizumab treatment were identified as switching candidates. Rather than switching, however, patients continued on ranibizumab treatment, and visual/anatomic outcomes from the timepoint of "hypothetical switch" were examined...
January 11, 2019: Ophthalmology
Marjean T Kulp, Jonathan M Holmes, Trevano W Dean, Donny W Suh, Raymond T Kraker, David K Wallace, David B Petersen, Susan A Cotter, Ruth E Manny, Rosanne Superstein, Tawna L Roberts, John M Avallone, Deborah R Fishman, S Ayse Erzurum, David Leske, Alex Christoff
OBJECTIVE: Two strategies were compared for managing moderate hyperopia without manifest strabismus among 1- and 2-year-old children: 1) immediate prescription of glasses vs 2) observation without glasses unless reduced distance visual acuity (VA), reduced stereoacuity, or manifest strabismus. DESIGN: Prospective randomized clinical trial PARTICIPANTS: 130 children 1 to 2 years old with hyperopia between +3.00 diopters (D) and +6.00D spherical equivalent (SE) in at least one eye, anisometropia ≤1...
January 4, 2019: Ophthalmology
Li Wang, Danmin Cao, Mitchell P Weikert, Douglas D Koch
PURPOSE: To investigate the difference between the segmented axial length (AL) and the displayed AL on an optical low-coherence reflectometry (OLCR) biometer (Part I) and to compare the refractive prediction errors calculated using the segmented and displayed ALs (Part II). DESIGN: Retrospective case series. PARTICIPANTS: 4992 eyes from 4992 subjects in Part I and 1758 eyes from 1758 subjects in Part II. METHODS: In Part I, we calculated the segmented AL as the sum of geometrical ocular segments converted from the optical path length (OPL) in each medium...
December 31, 2018: Ophthalmology
Hardeep Singh Mudhar, Rachel E Doherty, Sachin M Salvi, Zanna I Currie, Jennifer H Tan, Karen Sisley
No abstract text is available yet for this article.
December 31, 2018: Ophthalmology
Rei Sakata, Takeshi Yoshitomi, Aiko Iwase, Chota Matsumoto, Tomomi Higashide, Motohiro Shirakashi, Makoto Aihara, Kazuhisa Sugiyama, Makoto Araie
PURPOSE: To characterize the natural history and define the risk factors associated with the progression of normal-tension glaucoma (NTG) in Japanese patients who were followed up closely without treatment. DESIGN: Prospective 5-year study. PARTICIPANTS: Patients with NTG with intraocular pressure (IOP) consistently ≤15 mmHg without treatment at baseline. METHODS: Visual field (VF) examinations were performed every 3 months, and disc/peripapillary retina photographs were taken every 6 months...
December 31, 2018: Ophthalmology
Andrea Leonardi, Serge Doan, Mourad Amrane, Dahlia Ismail, Jesús Montero, János Németh, Pasquale Aragona, Dominique Bremond-Gignac
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe ocular disease affecting children and adolescents that can lead to impaired quality of life (QoL) and loss of vision. PURPOSE: This study evaluated the efficacy and safety of an investigational therapy for severe VKC, cyclosporine A cationic emulsion (CsA CE), an oil-in-water emulsion with increased bioavailability versus conventional CsA formulations. DESIGN: VEKTIS is a phase 3, multicenter, double-masked, vehicle-controlled trial...
December 26, 2018: Ophthalmology
Sachin Gupta, Ravilla D Ravindran, Ganesh-Babu B Subburaman, Ashok Vardhan S, Thulasiraj Ravilla
No abstract text is available yet for this article.
December 26, 2018: Ophthalmology
Mahiul M K Muqit, Michaela Velikay-Parel, Michel Weber, Gerard Dupeyron, Didier Audemard, Borja Corcostegui, José Sahel, Yannick Le Mer
No abstract text is available yet for this article.
December 24, 2018: Ophthalmology
Patrick A Sibony, Wei Hou
No abstract text is available yet for this article.
December 24, 2018: Ophthalmology
Ji-Ah Kim, Tae-Woo Kim, Eun Ji Lee, Michael J A Girard, Jean Martial Mari
PURPOSE: To compare regional variations in lamina cribrosa (LC) curvature and depth between healthy eyes (Group 1) and naïve eyes with primary open-angle glaucoma (POAG) having superior (Group 2), inferior (Group 3), and both (Group 4) hemifield retinal nerve fiber layer (RNFL) defects. DESIGN: Cross-sectional study PARTICIPANTS: Each group consisted of 39 eyes of 39 Korean patients who were matched for age, sex, and axial length. METHODS: The LC curvature index (LCCI) and LC depth (LCD) were measured in B-scan images obtained using enhanced depth imaging optical coherence tomography at seven locations spaced equidistantly across the vertical optic disc diameter...
December 24, 2018: Ophthalmology
Felipe A Medeiros, Alessandro A Jammal, Atalie C Thompson
PURPOSE: Previous approaches using deep learning algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative spectral-domain optical coherence tomography (SDOCT) data to train a deep learning algorithm to quantify glaucomatous structural damage on optic disc photographs. DESIGN: Cross-sectional study PARTICIPANTS: : 32,820 pairs of optic disc photos and SDOCT retinal nerve fiber layer (RNFL) scans from 2,312 eyes of 1,198 subjects...
December 19, 2018: Ophthalmology
Jinho Lee, Young Kook Kim, Ahnul Ha, Yong Woo Kim, Sung Uk Baek, Jin-Soo Kim, Haeng Jin Lee, Dai Woo Kim, Jin Wook Jeoung, Seong-Joon Kim, Ki Ho Park
PURPOSE: To evaluate the potential of the temporal raphe sign on the macular ganglion cell-inner plexiform layer (mGCIPL) thickness map for discriminating glaucomatous from non-glaucomatous optic neuropathy in eyes with mGCIPL thinning. DESIGN: Cross-sectional study. PARTICIPANTS: One-hundred and seventy-five eyes of 175 patients with mGCIPL thinning on Cirrus high-definition optical coherence tomography (OCT) were retrospectively included...
December 18, 2018: Ophthalmology
Jeremy C K Tan, Alexander C Ferdi, Mark C Gillies, Stephanie L Watson
TOPIC: Clinical registries in Ophthalmology CLINICAL RELEVANCE: In recent years advancements in digital technology and increasing use of the electronic medical record in health systems have led to the dramatic growth in large clinical data sets. Clinical data registries are organised systems which collect data on patients diagnosed with a disease or condition, or who undergo a certain procedure. METHODS: A search of the PUBMED database was conducted in January 2018 for clinical registries in ophthalmology...
December 17, 2018: Ophthalmology
Bhupesh Bagga, Joveeta Joseph, Prashant Garg, Kavya Chandran, Priyanka Jayabhasker, Kodiganti Manjulatha, Savitri Sharma
Miltefosine has been approved recently for Acanthamoeba keratitis (AK) after its successful use in animal model. This Pilot study is the first report of the efficacy of topical formulation of miltefosine in human subjects.
December 17, 2018: Ophthalmology
Ronald Klein, Kristine E Lee, Michael Y Tsai, Karen J Cruickshanks, Ronald E Gangnon, Barbara E K Klein
PURPOSE: To examine the relationship between serum oxidized low-density lipoprotein (ox-LDL) cholesterol and the incidence of age-related macular degeneration (AMD) over a 25-year period in a sample of persons from the population-based Beaver Dam Eye Study (BDES). DESIGN: Observational prospective cohort study. PARTICIPANTS: A total of 4,972 people from the BDES (aged 43 to 84 and living in Beaver Dam, Wisconsin in 1988) seen during at least one of six examination phases at approximately 5-year intervals between 1988 and 2016...
December 17, 2018: Ophthalmology
Ivan R Schwab, David G Heidemann
No abstract text is available yet for this article.
December 13, 2018: Ophthalmology
Takenori Inomata, Masahiro Nakamura, Masao Iwagami, Tina Shiang, Yusuke Yoshimura, Keiichi Fujimoto, Yuichi Okumura, Atsuko Eguchi, Nanami Iwata, Maria Miura, Satoshi Hori, Yoshimune Hiratsuka, Miki Uchino, Kazuo Tsubota, Reza Dana, Akira Murakami
This large-scale crowdsourced study using the iPhone application DryEyeRhythm identified the risk factors for severe dry eye disease-type symptoms, which included female sex, collagen disease, hay fever, depression, current contact-lens use, extended screen time, and smoking.
December 11, 2018: Ophthalmology
Seema Emami, Maram Isaac, Kamiar Mireskandari, Nasrin N Tehrani
No abstract text is available yet for this article.
December 8, 2018: Ophthalmology
J H Francis, T Milman, H Grossniklaus, D M Albert, R Folberg, G M Levitin, S E Coupland, F Catalanotti, D Rabady, C Kandoth, K J Busam, D H Abramson
PURPOSE: GNAQ mutations have been identified in port wine stains (both syndromic and non-syndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse- (those associated with Sturge-Weber syndrome (SWS)) and solitary choroidal hemangiomas. PARTICIPANTS: Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), choroidal nevus (n =1) METHODS: Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors...
December 8, 2018: Ophthalmology
Chu Luan Nguyen, Mark C Gillies, Vuong Nguyen, Vincent Daien, Amy Cohn, Gayatri Banerjee, Jennifer Arnold
PURPOSE: To investigate the incidence, characteristics and baseline predictors of poor visual outcomes in eyes with neovascular age-related macular degeneration (nAMD) receiving intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in daily clinical practice. DESIGN: Observational study. PARTICIPANTS: Treatment-naïve eyes starting anti-VEGF therapy for nAMD between 2007 and 2012 tracked in the Fight Retinal Blindness! registry...
December 6, 2018: Ophthalmology
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