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Ophthalmology

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https://www.readbyqxmd.com/read/28412070/evaluation-of-femtosecond-laser-intrastromal-incision-location-using-optical-coherence-tomography
#1
Li Wang, Lai Jiang, Katie Hallahan, Zaina N Al-Mohtaseb, Douglas D Koch
PURPOSE: To use optical coherence tomography (OCT) to evaluate the femtosecond laser intrastromal incisions made during cataract surgery to reduce corneal astigmatism. DESIGN: Retrospective case series. PARTICIPANTS: Seventy-seven eyes of 77 patients. METHODS: Paired intrastromal incisions were created using the Catalys femtosecond laser (Abbott Medical Optics, Inc., Santa Ana, CA). The planned intrastromal incision parameters were 20% uncut anterior, 20% uncut posterior, midpoint depth of 50%, and 90° side cut angle...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28412069/whole-exome-sequencing-identifies-biallelic-idh3a-variants-as-a-cause-of-retinitis-pigmentosa-accompanied-by-pseudocoloboma
#2
Laurence H M Pierrache, Adva Kimchi, Rinki Ratnapriya, Lisa Roberts, Galuh D N Astuti, Alexey Obolensky, Avigail Beryozkin, Martha J H Tjon-Fo-Sang, Jose Schuil, Caroline C W Klaver, Ernie M H F Bongers, Lonneke Haer-Wigman, Nicoline Schalij, Martijn H Breuning, Gratia M Fischer, Eyal Banin, Raj S Ramesar, Anand Swaroop, L Ingeborgh van den Born, Dror Sharon, Frans P M Cremers
PURPOSE: To identify the genetic cause of and describe the phenotype in 4 families with autosomal recessive retinitis pigmentosa (arRP) that can be associated with pseudocoloboma. DESIGN: Case series. PARTICIPANTS: Seven patients from 4 unrelated families with arRP, among whom 3 patients had bilateral early-onset macular pseudocoloboma. METHODS: We performed homozygosity mapping and whole-exome sequencing in 5 probands and 2 unaffected family members from 4 unrelated families...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28412068/vitreous-amyloidosis-ocular-systemic-and-genetic-insights
#3
Pradeep Venkatesh, Harathy Selvan, Sundararajan Baskar Singh, Divya Gupta, Seema Kashyap, Shreyas Temkar, Varun Gogia, Koushik Tripathy, Rohan Chawla, Rajpal Vohra
PURPOSE: To report the unique clinical and surgical characteristics encountered in eyes with vitreous amyloidosis. Systemic evaluation and visual outcome after vitrectomy are discussed. A novel mutation in the transthyretin gene (TTR) in Indian patients with familial amyloid polyneuropathy (FAP) is described. DESIGN: Retrospective, observational study. PARTICIPANTS: Ten eyes of 5 patients from 2 pedigrees with a diagnosis of vitreous amyloidosis...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28412067/trend-based-analysis-of-ganglion-cell-inner-plexiform-layer-thickness-changes-on-optical-coherence-tomography-in-glaucoma-progression
#4
Won June Lee, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
PURPOSE: To evaluate the rate of thinning in ganglion cell-inner plexiform layer (GCIPL) thickness by optical coherence tomography (OCT) in glaucomatous eyes and to use a trend-based approach to determine its diagnostic ability for detecting glaucoma progression. DESIGN: Prospective, observational study. PARTICIPANTS: Sixty-five patients with primary open-angle glaucoma with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28412066/ranibizumab-injection-as-primary-treatment-in-patients-with-retinopathy-of-prematurity-anatomic-outcomes-and-influencing-factors
#5
Qiujing Huang, Qi Zhang, Ping Fei, Yu Xu, Jiao Lyu, Xunda Ji, Jie Peng, Yi-An Li, Peiquan Zhao
PURPOSE: To investigate the anatomic outcomes and influencing factors of ranibizumab in the treatment of retinopathy of prematurity (ROP). DESIGN: Retrospective case series. PARTICIPANTS: A total of 283 eyes of 145 patients with type 1 ROP treated with intravitreal injection of ranibizumab (IVR) as primary treatment. METHODS: Retrospective review of infants who were diagnosed with type 1 ROP and accepted IVR (0.25 mg/0...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28408039/binocular-measures-of-visual-acuity-and-visual-field-versus-binocular-approximations
#6
David C Musch, Leslie M Niziol, Brenda W Gillespie, Paul R Lichter, Nancy K Janz
PURPOSE: To assess the relationship of binocular visual function tests with binocular approximations using data from the Collaborative Initial Glaucoma Treatment Study (CIGTS). DESIGN: Case series based on existing data from a clinical trial. PARTICIPANTS: Six hundred seven patients with newly diagnosed open-angle glaucoma from the CIGTS. METHODS: Monocular visual field (VF) and visual acuity (VA) tests were performed at baseline and every 6 months thereafter...
April 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28408038/temporal-relation-between-macular-ganglion-cell-inner-plexiform-layer-loss-and-peripapillary-retinal-nerve-fiber-layer-loss-in-glaucoma
#7
Young Kook Kim, Ahnul Ha, Kyeong Ik Na, Hae Jin Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the temporal relationship between inferior macular ganglion cell-inner plexiform layer (mGCIPL) loss and corresponding peripapillary retinal nerve fiber layer (pRNFL) defect on the optical coherence tomography (OCT) deviation map in glaucoma. DESIGN: Retrospective, observational study. PARTICIPANTS: A total of 151 patients with early-stage glaucoma (visual field [VF] mean deviation between -1.5 and -5.5 decibels [dB])...
April 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28385303/assessment-of-a-tele-education-system%C3%A2-to%C3%A2-enhance-retinopathy-of-prematurity-training-by-international-ophthalmologists-in-training-in-mexico
#8
Samir N Patel, Maria Ana Martinez-Castellanos, David Berrones-Medina, Ryan Swan, Michael C Ryan, Karyn E Jonas, Susan Ostmo, J Peter Campbell, Michael F Chiang, R V Paul Chan
PURPOSE: To evaluate a tele-education system developed to improve diagnostic competency in retinopathy of prematurity (ROP) by ophthalmologists-in-training in Mexico. DESIGN: Prospective, randomized cohort study. PARTICIPANTS: Fifty-eight ophthalmology residents and fellows from a training program in Mexico consented to participate. Twenty-nine of 58 trainees (50%) were randomized to the educational intervention (pretest, ROP tutorial, ROP educational chapters, and posttest), and 29 of 58 trainees (50%) were randomized to a control group (pretest and posttest only)...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28385302/subclassification-of-primary-angle-closure-using-anterior-segment-optical-coherence-tomography-and-ultrasound-biomicroscopic-parameters
#9
Junki Kwon, Kyung Rim Sung, Seungbong Han, Ye Ji Moon, Joong Won Shin
PURPOSE: To classify eyes with primary angle closure (PAC) in terms of the features visualized using anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). DESIGN: Retrospective, observational study. PARTICIPANTS: A total of 73 eyes of 73 patients with PAC. METHODS: Participants' eyes that had undergone laser peripheral iridotomy (LPI) were imaged using AS-OCT and UBM under the same lighting conditions...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28385301/marshall-m-parks-memorial-lecture-ocular-motor-misbehavior-in-children-where-neuro-ophthalmology-meets-strabismus
#10
REVIEW
Michael C Brodsky
Clinical diagnosis has been supplemented by neuroimaging advances, genetic discoveries, and molecular research to generate new neurobiological discoveries pertaining to early maldevelopment of ocular motor control systems. In this focused review, I examine recent paradigm shifts that have transformed our understanding of pediatric ocular motor disease at the prenuclear and infranuclear levels. The pathogenesis of complex ocular motor disorders, such as paradoxical pupillary constriction to darkness, benign tonic upgaze of infancy, congenital fibrosis syndrome, and the constellation of unique eye movements that accompany Joubert syndrome, are elucidated...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28385300/quality-of-life-and-functional-vision-in-children-with-glaucoma
#11
Annegret Dahlmann-Noor, Vijay Tailor, Catey Bunce, Yassir Abou-Rayyah, Gillian Adams, John Brookes, Peng T Khaw, Maria Papadopoulos
PURPOSE: To evaluate the effect of glaucoma on functional vision and on vision-related (VR) and health-related (HR) quality of life (QoL) in children up to 16 years of age. DESIGN: Cross-sectional observational study. PARTICIPANTS: One hundred nineteen children 2 to 16 years of age (mean age, 9.4 years; standard deviation [SD], 4.56 years) with glaucoma and their parents. METHODS: Completion of 3 validated instruments for children to assess (1) functional visual ability (FVA) with the Cardiff Visual Ability Questionnaire for Children (CVAQC), (2) VR QoL with the Impact of Vision Impairment for Children (IVI-C), and (3) HR QoL with the Pediatric Quality of Life Inventory (PedsQL) version 4...
April 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28377036/regression-patterns-of-iris-melanoma-after-palladium-103-103-pd-plaque-brachytherapy
#12
Sonal S Chaugule, Paul T Finger
PURPOSE: To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 ((103)Pd) plaque brachytherapy. DESIGN: Retrospective, nonrandomized, interventional case series. PARTICIPANTS: Fifty patients with primary malignant melanoma of the iris. METHODS: Palladium-103 plaque brachytherapy. MAIN OUTCOME MEASURES: Changes in tumor size, pigmentation, and vascularity; incidence of iris neovascularization; and radiation-related complications...
April 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28372861/use-of-standardization-of-uveitis-nomenclature-for-reporting-clinical-data-at-10-years
#13
Genevieve F Oliver, Roy M Stathis, Nicola J Spurrier, Justine R Smith
No abstract text is available yet for this article.
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28372860/treatment-patterns-for-myopic-choroidal-neovascularization-in-the-united-states-analysis-of-the-iris-registry
#14
Jeffrey Willis, Lawrence Morse, Susan Vitale, David W Parke, William L Rich, Flora Lum, Ronald A Cantrell
PURPOSE: To characterize treatment patterns and outcomes in eyes with treatment-naïve myopic choroidal neovascularization (mCNV) in the United States. DESIGN: Retrospective cohort study. PARTICIPANTS: Individuals aged 18 years and older seen in clinics participating in the American Academy of Ophthalmology's IRIS (Intelligent Research in Sight) Registry. METHODS: We analyzed data from the IRIS Registry, from January 1, 2012 to December 31, 2014, to identify cases of treatment-naïve mCNV, which was defined as the presence of myopic refractive error worse than -6...
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28372859/the-wedge-sign-an-imaging-sign-for-aggressive-lacrimal-gland-disease
#15
Daniele Lorenzano, Geoffrey E Rose
PURPOSE: Lacrimal gland carcinoma can form a triangle of tissue back to the orbital apex, intraconal spread apparently being prevented by the intermuscular septum. The "wedge sign" frequency is assessed in lacrimal carcinoma, lacrimal lymphoma, or dacryoadenitis. DESIGN: Retrospective masked review of images from patients with biopsy-proven lacrimal gland pathology. METHODS: For each patient, the presence of a triangle of tissue between the lateral rectus and lateral orbital wall and the superior rectus and the orbital roof was assessed by masked review of computed tomography or magnetic resonance imaging...
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28372858/visual-field-progression-in-patients-with-primary-angle-closure-glaucoma-using-pointwise-linear-regression-analysis
#16
Sushma Verma, Monisha E Nongpiur, Eray Atalay, Xin Wei, Rahat Husain, David Goh, Shamira A Perera, Tin Aung
PURPOSE: To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG) using pointwise linear regression (PLR) trend analysis. DESIGN: Clinic-based retrospective study. PARTICIPANTS: Primary angle-closure glaucoma patients with 5 or more reliable VF tests and with 5 years or more of follow-up. METHODS: Visual field progression was assessed by PROGRESSOR software version 3...
March 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28366503/benign-yellow-dot-maculopathy-a-new-macular-phenotype
#17
Arundhati Dev Borman, Aleksandra Rachitskaya, Martina Suzani, Robert A Sisk, Zubair M Ahmed, Graham E Holder, Valentina Cipriani, Gavin Arno, Andrew R Webster, Robert B Hufnagel, Audina Berrocal, Anthony T Moore
PURPOSE: To describe a novel macular phenotype that is associated with normal visual function. DESIGN: Retrospective, observational case series. PARTICIPANTS: Thirty-six affected individuals from 23 unrelated families. METHODS: This was a retrospective study of patients who had a characteristic macular phenotype. Subjects underwent a full ocular examination, electrophysiologic studies, spectral-domain optical coherence tomography (OCT), and fundus autofluorescence imaging...
March 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28365209/special-commentary-early-clinical-development-of-cell-replacement-therapy-considerations-for-the-national-eye-institute-audacious-goals-initiative
#18
REVIEW
Leonard A Levin, Joan W Miller, Donald J Zack, Martin Friedlander, Lois E H Smith
The National Eye Institute launched the Audacious Goals Initiative (AGI) in 2013 with the aim "to restore vision through the regeneration of neurons and neural connections in the eye and visual system." An AGI Town Hall held at the Association for Research in Vision and Ophthalmology Annual Meeting in 2016 brought together basic, translational, and clinical scientists to address the clinical implications of the AGI, with a particular emphasis on diseases amenable to regenerative medicine and strategies to deal with barriers to progess...
March 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28359545/automated-identification-of-diabetic-retinopathy-using-deep-learning
#19
Rishab Gargeya, Theodore Leng
PURPOSE: Diabetic retinopathy (DR) is one of the leading causes of preventable blindness globally. Performing retinal screening examinations on all diabetic patients is an unmet need, and there are many undiagnosed and untreated cases of DR. The objective of this study was to develop robust diagnostic technology to automate DR screening. Referral of eyes with DR to an ophthalmologist for further evaluation and treatment would aid in reducing the rate of vision loss, enabling timely and accurate diagnoses...
March 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28341476/panel-based-clinical-genetic-testing-in-85-children-with-inherited-retinal-disease
#20
Rachel L Taylor, Neil R A Parry, Stephanie J Barton, Christopher Campbell, Claire M Delaney, Jamie M Ellingford, Georgina Hall, Claire Hardcastle, Jiten Morarji, Elisabeth J Nichol, Lindsi C Williams, Sofia Douzgou, Jill Clayton-Smith, Simon C Ramsden, Vinod Sharma, Susmito Biswas, I Chris Lloyd, Jane L Ashworth, Graeme C Black, Panagiotis I Sergouniotis
PURPOSE: To assess the clinical usefulness of genetic testing in a pediatric population with inherited retinal disease (IRD). DESIGN: Single-center retrospective case series. PARTICIPANTS: Eighty-five unrelated children with a diagnosis of isolated or syndromic IRD who were referred for clinical genetic testing between January 2014 and July 2016. METHODS: Participants underwent a detailed ophthalmic examination, accompanied by electrodiagnostic testing (EDT) and dysmorphologic assessment where appropriate...
March 21, 2017: Ophthalmology
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