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Ophthalmology

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https://www.readbyqxmd.com/read/28215452/myopic-shift-5-years-after-intraocular-lens-implantation-in-the-infant-aphakia-treatment-study
#1
David R Weakley, Michael J Lynn, Lindreth Dubois, George Cotsonis, M Edward Wilson, Edward G Buckley, David A Plager, Scott R Lambert
PURPOSE: To report the myopic shift at 5 years of age after cataract surgery with intraocular lens (IOL) implantation for infants enrolled in the Infant Aphakia Treatment Study (IATS). METHODS: Refractions were performed at 1 month and every 3 months postoperatively until age 4 years and then at ages 4.25, 4.5, and 5 years. The change in refraction over time was estimated by linear mixed model analysis. RESULTS: Intraocular lens implantation was completed in 56 eyes; 43 were analyzed (median age, 2...
February 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28214102/vitreomacular-adhesion-and-the-risk-of-neovascular-age-related-macular-degeneration
#2
Emilia Maggio, Antonio Polito, Massimo Guerriero, Guido Prigione, Barbara Parolini, Grazia Pertile
PURPOSE: To assess the prevalence of vitreomacular adhesion (VMA) in consecutive naïve eyes diagnosed with exudative age-related macular degeneration (AMD) in comparison with eyes with nonexudative AMD and age-matched controls, and to evaluate prospectively the incidence of vitreomacular interface changes over time and their influence on choroidal neovascularization (CNV) development. DESIGN: Retrospective cross-sectional analysis and longitudinal cohort study conducted at Sacrocuore Hospital, Negrar, Verona, Italy...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28214101/endophthalmitis-reduction-with-intracameral-moxifloxacin-prophylaxis-analysis-of-600%C3%A2-000-surgeries
#3
Aravind Haripriya, David F Chang, Ravilla D Ravindran
PURPOSE: To compare the postoperative endophthalmitis rate before and after initiation of intracameral (IC) moxifloxacin prophylaxis for both phacoemulsification and sutureless, manual small-incision cataract surgery (M-SICS), as well as in patients with posterior capsular rupture (PCR). DESIGN: Retrospective, clinical registry. PARTICIPANTS: All cataract surgeries (617 453) performed during the 29-month period from January 2014 to May 2016 at the 10 regional Aravind eye hospitals were included...
February 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196733/the-proportion-of-individuals-likely-to-benefit-from-customized-optic-nerve-head-structure-function-mapping
#4
Allison M McKendrick, Jonathan Denniss, Ya Xing Wang, Jost B Jonas, Andrew Turpin
PURPOSE: Interindividual variance in optic nerve head (ONH) position, axial length, and location of the temporal raphe suggest that customizing mapping between visual field locations and ONH sectors for individuals may be clinically useful. Herein we quantify the proportion of the population predicted to have structure-function mappings that markedly deviate from "average," and thus would benefit from customized mapping. DESIGN: Database study and case report. PARTICIPANTS: Population database of 2836 eyes from the Beijing Eye Study and a single case report of an individual with primary open-angle glaucoma...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196732/peripapillary-and-macular-vessel-density-in-patients-with-glaucoma-and-single-hemifield-visual-field-defect
#5
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Luke J Saunders, Min Hee Suh, Zhichao Wu, Patricia Isabel C Manalastas, Tadamichi Akagi, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To compare hemifield differences in the vessel density of the peripapillary and macula in open-angle glaucoma eyes with visual field (VF) defect confined to one hemifield using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectional study. PARTICIPANTS: A total of 58 eyes of 58 patients with glaucoma with VF loss confined to a single hemifield and 28 healthy eyes. METHODS: Retinal vasculature information was summarized as circumpapillary vessel density (cpVD) and perifoveal vessel density (pfVD)...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196731/natural-history-of-conversion-of-leber-s-hereditary-optic-neuropathy-a-prospective-case-series
#6
Tiffany Jean Hwang, Rustum Karanjia, Milton Nunes Moraes-Filho, Jesse Gale, Jeffrey Show Tran, Edward R Chu, Solange R Salomao, Adriana Berezovsky, Rubens Belfort, Milton Nunes Moraes, Federico Sadun, Anna Maria DeNegri, Chiara La Morgia, Piero Barboni, Carolina do V F Ramos, Carlos Filipe Chicani, Peter A Quiros, Valerio Carelli, Alfredo A Sadun
PURPOSE: To illustrate the natural history of Leber's hereditary optic neuropathy (LHON). DESIGN: Prospective observational case series. PARTICIPANTS: The Soave-Brazil pedigree of m.11778G>A/ND4 mitochondrial DNA LHON mutation. METHODS: A prospectively acquired database of the Soave-Brazil pedigree was reviewed. Data from 285 individuals were included in the database over a 15-year period. The pedigree was reviewed for unaffected mutation carriers who converted to affected status, 6 patients with LHON were identified...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28196730/globe-axial-length-growth-at-age-5-years-in-the-infant-aphakia-treatment-study
#7
M Edward Wilson, Rupal H Trivedi, David R Weakley, George A Cotsonis, Scott R Lambert
PURPOSE: To report the longitudinal change in axial length (AL) from the time of unilateral cataract surgery at age 1 to 7 months to age 5 years, and to compare AL growth of operated eyes with that of fellow unoperated eyes. DESIGN: Comparative case series. PARTICIPANTS: Infants enrolled in the Infant Aphakia Treatment Study (IATS). METHODS: The AL at baseline and age 5 years and change in AL were analyzed relative to treated versus fellow eye, visual outcome, and treatment modality (contact lens [CL] vs...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28187978/optical-coherence-tomography-examination-of-the-retinal-pigment-epithelium-in-best-vitelliform-macular-dystrophy
#8
Cynthia X Qian, Dionisio Charran, Cameron R Strong, Timothy J Steffens, Thiran Jayasundera, John R Heckenlively
PURPOSE: To describe the anatomic changes and natural history of vitelliform lesions in Best vitelliform macular dystrophy (BVMD) using spectral-domain optical coherence tomography (OCT). DESIGN: Prospective comparative case series. PARTICIPANTS: Twenty patients (40 eyes) with molecular confirmation of mutation in the BEST1 gene and 20 age-matched controls were included. METHODS: Color fundus photographs, fundus autofluorescence, and spectral-domain OCT were obtained, and these findings were compared between the 2 groups...
February 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28187977/retinal-and-optic-nerve-degeneration-in-patients-with-multiple-sclerosis-followed-up-for-5-years
#9
Elena Garcia-Martin, Jose R Ara, Jesus Martin, Carmen Almarcegui, Isabel Dolz, Elisa Vilades, Laura Gil-Arribas, Francisco J Fernandez, Vicente Polo, Jose M Larrosa, Luis E Pablo, Maria Satue
PURPOSE: To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration. DESIGN: Observational and longitudinal study. PARTICIPANTS: One hundred patients with relapsing-remitting MS and 50 healthy controls. METHODS: All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years...
February 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28187976/re-evaluating-the-incidence-of-idiopathic-intracranial-hypertension-in-an-era-of-increasing-obesity
#10
Khin P Kilgore, Michael S Lee, Jacqueline A Leavitt, Bahram Mokri, David O Hodge, Ryan D Frank, John J Chen
PURPOSE: To re-evaluate the population-based incidence of idiopathic intracranial hypertension (IIH) and to determine if it mirrors the rise in obesity. DESIGN: Retrospective, population-based cohort. PARTICIPANTS: All residents of Olmsted County, Minnesota, diagnosed with IIH between January 1, 1990, and December 31, 2014. METHODS: All cases of IIH were identified using the Rochester Epidemiology Project, which is a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents...
February 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28161147/factors-associated-with-worsening-proliferative-diabetic-retinopathy-in-eyes-treated-with-panretinal-photocoagulation-or-ranibizumab
#11
Susan B Bressler, Wesley T Beaulieu, Adam R Glassman, Jeffrey G Gross, Lee M Jampol, Michele Melia, Mark A Peters, Michael E Rauser
PURPOSE: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab. DESIGN: Randomized clinical trial (55 United States sites). PARTICIPANTS: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. INTERVENTION: Panretinal photocoagulation or intravitreous ranibizumab injections (0...
February 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28159380/cytogenetic-abnormalities-in-uveal-melanoma-based-on-tumor-features-and-size-in-1059-patients-the-2016-w-richard-green-lecture
#12
Carol L Shields, Emil Anthony T Say, Murat Hasanreisoglu, Jarin Saktanasate, Brendan M Lawson, Jeffrey E Landy, Anjali U Badami, Meera D Sivalingam, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
PURPOSE: To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN: Retrospective case series. PARTICIPANTS: A total of 1059 patients with uveal melanoma. METHODS: Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOME MEASURES: Risk for cytogenetic abnormalities based on features and size: small (≤3 mm thickness), medium (>3-<8 mm), and large (≥8 mm)...
January 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28159379/factors-affecting-visits-to-the-emergency-department-for-urgent-and-nonurgent-ocular-conditions
#13
Brian C Stagg, Muazzum M Shah, Nidhi Talwar, Dolly A Padovani-Claudio, Maria A Woodward, Joshua D Stein
PURPOSE: To determine the frequency of emergency department (ED) visits for nonurgent and urgent ocular conditions and risk factors associated with ED use for nonurgent and urgent ocular problems. DESIGN: Retrospective, longitudinal cohort analysis. PARTICIPANTS: All enrollees aged 21 years or older in a United States managed care network during 2001-2014. METHODS: We identified all enrollees visiting an ED for ocular conditions identified by International Classification of Diseases, billing codes...
January 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28153442/histologic-and-optical-coherence-tomographic-correlates-in-drusenoid-pigment-epithelium-detachment-in-age-related-macular-degeneration
#14
Chandrakumar Balaratnasingam, Jeffrey D Messinger, Kenneth R Sloan, Lawrence A Yannuzzi, K Bailey Freund, Christine A Curcio
PURPOSE: Drusenoid pigment epithelium detachment (DPED) is a known precursor to geographic atrophy in age-related macular degeneration (AMD). We sought histologic correlates for spectral-domain (SD) optical coherence tomography (OCT) signatures in DPED and determined the frequency and origin of these OCT signatures in a clinical cohort of DPED eyes. DESIGN: Laboratory imaging and histologic comparison, and retrospective, observational cohort study. PARTICIPANTS: Four donor eyes with histopathologic diagnosis of AMD (2 with nonneovascular DPED and 2 with neovascular pigment epithelium detachment [PED]) and 49 eyes of 33 clinic patients with nonneovascular DPED more than 2 mm in diameter...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28153441/dietary-intakes-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-and-risk-of-age-related-macular-degeneration
#15
Juan Wu, Eunyoung Cho, Edward L Giovannucci, Bernard A Rosner, Srinivas M Sastry, Walter C Willett, Debra A Schaumberg
PURPOSE: To evaluate the associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the intermediate and advanced stages of age-related macular degeneration (AMD). DESIGN: Prospective cohort study. PARTICIPANTS: We followed 75 889 women from the Nurses' Health Study and 38 961 men from the Health Professionals Follow-Up Study who were at least 50 years old, from 1984 to 2012 and 1986 to 2010, respectively...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28153440/adherence-to-hydroxychloroquine-dosing-guidelines-by-rheumatologists-an-electronic-medical-record-based-study-in-an-integrated-health-care-system
#16
Rebekah A Braslow, Mira Shiloach, Marian S Macsai
PURPOSE: To study the adherence of rheumatologists to the hydroxychloroquine (HCQ) dosing guidelines established by the American Academy of Ophthalmology in 2011 and 2016. DESIGN: Retrospective review of electronic medical records (EMRs) in an integrated health care system. PARTICIPANTS: All rheumatology patients started on HCQ who were seen by a NorthShore ophthalmologist between the years 2009 and 2016. METHODS: Data on patient weights, height, gender, and HCQ dosage were extracted from the EMR...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28153439/validation-of-the-retinal-detachment-after-open-globe-injury-rd-ogi-score-as-an-effective-tool-for-predicting-retinal-detachment
#17
Katarzyna Brodowska, Tomasz P Stryjewski, Evangelia Papavasileiou, Yewlin E Chee, Dean Eliott
PURPOSE: The Retinal Detachment after Open Globe Injury (RD-OGI) Score is a clinical prediction model that was developed at the Massachusetts Eye and Ear Infirmary to predict the risk of retinal detachment (RD) after open globe injury (OGI). This study sought to validate the RD-OGI Score in an independent cohort of patients. DESIGN: Retrospective cohort study. PARTICIPANTS: The predictive value of the RD-OGI Score was evaluated by comparing the original RD-OGI Scores of 893 eyes with OGI that presented between 1999 and 2011 (the derivation cohort) with 184 eyes with OGI that presented from January 1, 2012, to January 31, 2014 (the validation cohort)...
January 30, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28139245/a-metabolome-wide-study-of-dry-eye-disease-reveals-serum-androgens-as%C3%A2-biomarkers
#18
Jelle Vehof, Pirro G Hysi, Christopher J Hammond
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years). METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc...
January 28, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28132724/reading-ability-among-patients-presenting-for-ophthalmic-and-nonophthalmic-surgery
#19
Regina A de Luna, Angeline M Nguyen, Pradeep Y Ramulu
No abstract text is available yet for this article.
January 26, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28129969/new-surgeon-outcomes-and-the-effectiveness-of-surgical-training-a-population-based-cohort-study
#20
Robert J Campbell, Sherif R El-Defrawy, Sudeep S Gill, Marlo Whitehead, Erica de L P Campbell, Philip L Hooper, Chaim M Bell, Martin Ten Hove
PURPOSE: Reports have questioned the technical proficiency of newly graduating surgeons. However, objective data supporting these concerns are limited. Surgical outcomes among recent graduates are an important indicator of residency programs' ability to graduate surgeons who are ready to meet the needs of their patients. This study aimed to investigate the association between a surgeon's number of years of independent practice and the risk of surgical adverse events. DESIGN: Population-based cohort study...
January 24, 2017: Ophthalmology
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