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Ophthalmology

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https://www.readbyqxmd.com/read/28089680/peripheral-retinal-changes-associated-with%C3%A2-age-related-macular-degeneration-in%C3%A2-the-age-related-eye-disease-study-2-age-related-eye-disease-study-2-report-number-12-by-the%C3%A2-age-related-eye-disease-study-2-optos-peripheral-retina-opera-study-research-group
#1
Amitha Domalpally, Traci E Clemons, Ronald P Danis, SriniVas R Sadda, Catherine A Cukras, Cynthia A Toth, Thomas R Friberg, Emily Y Chew
PURPOSE: To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). DESIGN: Cross-sectional evaluation of clinic-based patients enrolled in AREDS2 and a prospective study. PARTICIPANTS: Participants from prospective studies. METHODS: The 200° pseudocolor and fundus autofluorescence (FAF) images were captured on the Optos 200 Tx Ultrawide-field device (Optos, Dunfermline, Scotland) by centering on the fovea and then steering superiorly and inferiorly...
January 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28089679/efficacy-and-toxicity-of-intravitreous-chemotherapy-for-retinoblastoma-four-year-experience
#2
Jasmine H Francis, Scott E Brodie, Brian Marr, Emily C Zabor, Ijah Mondesire-Crump, David H Abramson
PURPOSE: To investigate the efficacy and toxicity of intravitreous melphalan for treatment of retinoblastoma, as a single agent or with concomitant topotecan. PARTICIPANTS: A total of 130 eyes of 120 patients with retinoblastoma receiving 630 intravitreous (melphalan, topotecan) or topotecan periocular injections. A total of 83 (64%) of these eyes were treated with concomitant ophthalmic artery chemosurgery (OAC). DESIGN: Retrospective cohort study...
January 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28081945/long-term-effects-of-intravitreal-0-19-mg-fluocinolone-acetonide-implant-on-progression-and-regression-of-diabetic-retinopathy
#3
Charles C Wykoff, Usha Chakravarthy, Peter A Campochiaro, Clare Bailey, Ken Green, Jose Cunha-Vaz
OBJECTIVE: To investigate the effects of fluocinolone acetonide (FAc) on the progression to proliferative diabetic retinopathy (PDR) and the impact of FAc on changes in Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity scale (DRSS) grade during the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) A and B Phase III clinical trials. DESIGN: Post hoc analysis of data from the 36-month prospective, randomized, FAME A and B trials...
January 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28081944/early-experience-with-technology-based-eye-care-services-tecs-a-novel-ophthalmologic-telemedicine-initiative
#4
April Y Maa, Barbara Wojciechowski, Kelly J Hunt, Clara Dismuke, Jason Shyu, Rabeea Janjua, Xiaoqin Lu, Charles M Medert, Mary G Lynch
PURPOSE: The aging population is at risk of common eye diseases, and routine eye examinations are recommended to prevent visual impairment. Unfortunately, patients are less likely to seek care as they age, which may be the result of significant travel and time burdens associated with going to an eye clinic in person. A new method of eye-care delivery that mitigates distance barriers and improves access was developed to improve screening for potentially blinding conditions. We present the quality data from the early experience (first 13 months) of Technology-Based Eye Care Services (TECS), a novel ophthalmologic telemedicine program...
January 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28081943/capturing-the-moment-of-fusion-loss-in-intermittent-exotropia
#5
John R Economides, Daniel L Adams, Jonathan C Horton
PURPOSE: To characterize eye movements made by patients with intermittent exotropia when fusion loss occurs spontaneously and to compare them with those induced by covering 1 eye and with strategies used to recover fusion. DESIGN: Prospective study of a patient cohort referred to our laboratory. PARTICIPANTS: Thirteen patients with typical findings of intermittent exotropia who experienced frequent spontaneous loss of fusion. METHODS: The position of each eye was recorded with a video eye tracker under infrared illumination while fixating on a small central near target...
January 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28065436/long-term-posterior-capsule-opacification-reduction-with-square-edge-polymethylmethacrylate-intraocular-lens-randomized-controlled-study
#6
Aravind Haripriya, David F Chang, Balakrishnan Vijayakumar, Agrawal Niraj, Madhu Shekhar, Singh Tanpreet, Srinivasan Aravind
PURPOSE: To objectively assess the long-term posterior capsule opacification (PCO) and neodymium-doped yttrium aluminium garnet (Nd:YAG) capsulotomy rate of a square-edge (SE) polymethylmethacrylate (PMMA) intraocular lens (IOL) modification in comparison with a round-edge (RE) PMMA IOL or an SE hydrophobic acrylic IOL (SE-Acrylic). DESIGN: Prospective, randomized, controlled fellow eye clinical study. PARTICIPANTS: Ninety-four patients scheduled for bilateral phacoemulsification had an SE-PMMA IOL implanted in 1 eye...
January 5, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28038984/type-2-diabetes-genetic-variants-and-risk-of-diabetic-retinopathy
#7
Yong He Chong, Qiao Fan, Yih Chung Tham, Alfred Gan, Shu Pei Tan, Gavin Tan, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: Genetic association studies to date have not identified any robust risk loci for diabetic retinopathy (DR). We hypothesized that individuals with more diabetes genetic risk alleles have a higher risk of developing DR. DESIGN: Case-control genetic association study. PARTICIPANTS: We evaluated the aggregate effects of multiple type 2 diabetes-associated genetic variants on the risk of DR among 1528 participants with diabetes from the Singapore Epidemiology of Eye Diseases Study, of whom 547 (35...
December 27, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28038983/evaluation-of-the-myocilin-mutation-gln368stop-demonstrates-reduced-penetrance-for-glaucoma-in-european-populations
#8
Abhishek Nag, Han Lu, Matthew Arno, Adriana I Iglesias, Pieter Bonnemaijer, Linda Broer, Andre G Uitterlinden, Caroline C W Klaver, Cornelia van Duijn, Pirro G Hysi, Christopher J Hammond
PURPOSE: Sequence variations in the myocilin (MYOC) gene account for approximately 2% to 4% of glaucoma cases. One particular MYOC mutation, Gln368Stop (dbSNP accession number: rs74315329), is the most common genetic mutation causing glaucoma by increasing intraocular pressure (IOP). The objective of this study was to evaluate the effect of this MYOC mutation on IOP using data from large-scale European population panels (directly sequenced and imputation based). DESIGN: Cross-sectional, cohort study...
December 27, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28024826/predictors-of-discordance-between-symptoms-and-signs-in-dry-eye-disease
#9
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate predictors of discordance between symptoms and signs in dry eye disease (DED). DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands. METHODS: Patient symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Dry eye signs were assessed by tear osmolarity, Schirmer test, tear breakup time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a composite dry eye signs severity score was calculated from these 6 tests for each patient...
December 23, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28024825/automated-diabetic-retinopathy-image-assessment-software-diagnostic-accuracy-and-cost-effectiveness-compared-with-human-graders
#10
Adnan Tufail, Caroline Rudisill, Catherine Egan, Venediktos V Kapetanakis, Sebastian Salas-Vega, Christopher G Owen, Aaron Lee, Vern Louw, John Anderson, Gerald Liew, Louis Bolter, Sowmya Srinivas, Muneeswar Nittala, SriniVas Sadda, Paul Taylor, Alicja R Rudnicka
OBJECTIVE: With the increasing prevalence of diabetes, annual screening for diabetic retinopathy (DR) by expert human grading of retinal images is challenging. Automated DR image assessment systems (ARIAS) may provide clinically effective and cost-effective detection of retinopathy. We aimed to determine whether ARIAS can be safely introduced into DR screening pathways to replace human graders. DESIGN: Observational measurement comparison study of human graders following a national screening program for DR versus ARIAS...
December 23, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017424/predictors-of-long-term-visual-outcome-in-intermediate-uveitis
#11
Rachael L Niederer, Lazha Sharief, Asaf Bar, Sue L Lightman, Oren Tomkins-Netzer
PURPOSE: To describe factors that predict visual loss and complications in intermediate uveitis. DESIGN: Cross-sectional study. PARTICIPANTS: Subjects with intermediate uveitis were identified from a database of 1254 uveitis patients seen in the clinic of a single consultant (S.L.L.) between 2011 and 2013. METHODS: Information was gathered from the clinical notes of all subjects examined in clinic. MAIN OUTCOME MEASURES: Best-corrected visual acuity (BCVA), moderate visual loss (MVL; ≤20/50), severe visual loss (SVL; ≤20/200)...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017423/operating-room-performance-improves-after-proficiency-based-virtual-reality-cataract-surgery-training
#12
Ann Sofia Skou Thomsen, Daniella Bach-Holm, Hadi Kjærbo, Klavs Højgaard-Olsen, Yousif Subhi, George M Saleh, Yoon Soo Park, Morten la Cour, Lars Konge
PURPOSE: To investigate the effect of virtual reality proficiency-based training on actual cataract surgery performance. The secondary purpose of the study was to define which surgeons benefit from virtual reality training. DESIGN: Multicenter masked clinical trial. PARTICIPANTS: Eighteen cataract surgeons with different levels of experience. METHODS: Cataract surgical training on a virtual reality simulator (EyeSi) until a proficiency-based test was passed...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017422/quantifying-fall-related-hazards-in-the-homes-of-persons-with-glaucoma
#13
Andrea V Yonge, Bonnielin K Swenor, Rhonda Miller, Victoria Goldhammer, Sheila K West, David S Friedman, Laura N Gitlin, Pradeep Y Ramulu
OBJECTIVE: To characterize fall-related hazards in the homes of persons with suspected or diagnosed glaucoma, and to determine whether those with worse visual field (VF) damage have fewer home hazards. DESIGN: Cross-sectional study using baseline (2013-2015) data from the ongoing Falls in Glaucoma Study (FIGS). PARTICIPANTS: One-hundred seventy-four of 245 (71.0%) FIGS participants agreeing to the home assessment. METHODS: Participants' homes were assessed using the Home Environment Assessment for the Visually Impaired (HEAVI)...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017421/steroid-sparing-effect-of-0-1-tacrolimus-eye-drop-for-treatment-of-shield-ulcer-and-corneal-epitheliopathy-in-refractory-allergic-ocular-diseases
#14
Dai Miyazaki, Atsuki Fukushima, Yuichi Ohashi, Nobuyuki Ebihara, Eiichi Uchio, Shigeki Okamoto, Jun Shoji, Etsuko Takamura, Yayoi Nakagawa, Kenichi Namba, Hiroshi Fujishima
PURPOSE: To evaluate the effects of 0.1% topical tacrolimus alone or in combination with steroids for the treatment of shield ulcers and corneal epitheliopathy in patients with refractory allergic ocular diseases. DESIGN: Open cohort study. PARTICIPANTS: Patients with refractory allergic conjunctivitis epitheliopathy, shield ulcers, or corneal plaques (N = 791). METHODS: The 791 patients were treated with topical tacrolimus alone or in combination with topical or oral steroids...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28017420/comparison-of-visual-outcomes-of-nonarteritic-anterior-ischemic-optic-neuropathy-in-patients-with-and-without-diabetes-mellitus
#15
Srilakshmi Sharma, Sarah Kwan, Katherine A Fallano, Jiangxia Wang, Neil R Miller, Prem S Subramanian
PURPOSE: Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN: Case-control study. PARTICIPANTS: All 231 patients with NAION seen by the Neuro-Ophthalmology Service, Wilmer Eye Institute, between 2002 and 2011 were screened for study inclusion...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28010938/deep-lamellar-endothelial-keratoplasty-clinical-outcome-the-13-to-18-year-follow-up
#16
Hilde C M Hooijmaijers, Marina Rodriguez-Calvo-de-Mora, Korine van Dijk, Lisanne Ham, Carla Nieuwendaal, Gerrit R J Melles
No abstract text is available yet for this article.
December 20, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27993484/myocilin-predictive-genetic-testing-for-primary-open-angle-glaucoma-leads-to-early-identification-of-at-risk-individuals
#17
Emmanuelle Souzeau, Kien Hou Tram, Martin Witney, Jonathan B Ruddle, Stuart L Graham, Paul R Healey, Ivan Goldberg, David A Mackey, Alex W Hewitt, Kathryn P Burdon, Jamie E Craig
PURPOSE: To assess the difference in severity of disease in primary open-angle glaucoma (POAG) patients with a Myocilin (MYOC) disease-causing variant who presented through normal clinical pathways (Clinical cases) versus those who were examined following genetic testing (Genetic cases). DESIGN: Retrospective clinical and molecular study. PARTICIPANTS: Seventy-three MYOC mutation carriers identified through the Australian and New Zealand Registry of Advanced Glaucoma...
December 16, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27993483/lens-power-axial-length-to-corneal-radius-ratio-and-association-with-diabetic-retinopathy-in-the-adult-population-with%C3%A2-type-2-diabetes
#18
Jiangnan He, Xian Xu, Jianfeng Zhu, Bijun Zhu, Bo Zhang, Lina Lu, Xiangui He, Xuelin Bai, Xun Xu, Haidong Zou
PURPOSE: To calculate crystalline lens power and to determine the relationship between ocular biometry and diabetic retinopathy (DR) in an adult population with type 2 diabetes mellitus (T2DM). DESIGN: Cross-sectional, population-based study. PARTICIPANTS: Patients with T2DM from the Beixinjing community, Changning district, Shanghai. METHODS: Random clustering sampling was used to identify adults with T2DM in the Beixinjing community...
December 16, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27986386/intraocular-hemorrhages-and-retinopathy-of-prematurity-in-the-telemedicine-approaches-to-evaluating-acute-phase-retinopathy-of-prematurity-e-rop-study
#19
Ebenezer Daniel, Gui-Shuang Ying, R Michael Siatkowski, Wei Pan, Eli Smith, Graham E Quinn
PURPOSE: To describe the clinical characteristics of intraocular hemorrhages (IOHs) in infants in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study and to evaluate their potential use for prediction of disease severity. DESIGN: Secondary data analysis from a prospective study. PARTICIPANTS: Preterm infants with birth weight (BW) ≤1250 g. METHODS: Infants underwent serial digital retinal imaging in both eyes starting at 32 weeks' postmenstrual age...
December 13, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27986385/natural-history-of-the-central-structural-abnormalities-in-choroideremia-a-prospective-cross-sectional-study
#20
Tomas S Aleman, Grace Han, Leona W Serrano, Nicole M Fuerst, Emily S Charlson, Denise J Pearson, Daniel C Chung, Anastasia Traband, Wei Pan, Gui-Shuang Ying, Jean Bennett, Albert M Maguire, Jessica I W Morgan
PURPOSE: To describe in detail the central retinal structure of a large group of patients with choroideremia (CHM). DESIGN: A prospective, cross-sectional, descriptive study. PARTICIPANTS: Patients (n = 97, age 6-71 years) with CHM and subjects with normal vision (n = 44; ages 10-50 years) were included. METHODS: Subjects were examined with spectral-domain optical coherence tomography (SD OCT) and near-infrared reflectance imaging...
December 13, 2016: Ophthalmology
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