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Carla J Siegfried
No abstract text is available yet for this article.
September 18, 2018: Ophthalmology
Tyler Hyungtaek Rim, Tae Keun Yoo, Jiyong Kwak, Jihei Sara Lee, Seo Hee Kim, Dong Wook Kim, Sung Soo Kim
PURPOSE: The association between long-term cardioprotective aspirin use and neovascular age-related macular degeneration is controversial. This study was undertaken to estimate the risk of neovascular age-related macular degeneration with long-term regular use of low-dose aspirin. DESIGN: Retrospective population-based study, using a nationwide cohort from a variety of clinics and hospitals in South Korea. PARTICIPANTS: Nonregular aspirin users and regular aspirin users under national health insurance, aged ≥45 years, who were followed from 2010 through 2015, were identified...
September 18, 2018: Ophthalmology
Yuzhen Jiang, Bei Tian
No abstract text is available yet for this article.
September 6, 2018: Ophthalmology
Min-Woo Lee, Ju-Mi Kim, Yong-Il Shin, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To determine longitudinal change of peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with high myopia without ophthalmic disease. DESIGN: Prospective observational study. PARTICIPANTS: Participants were divided into 2 groups: a high myopia group (80 eyes) that included eyes with an axial length ≥26.0 mm and a control group (80 eyes) that included eyes with a spherical equivalent (SE) between +3.0 and -6.0 diopters (D)...
September 5, 2018: Ophthalmology
Glenn J Jaffe, Gui-Shuang Ying, Cynthia A Toth, Ebenezer Daniel, Juan E Grunwald, Daniel F Martin, Maureen G Maguire
OBJECTIVE: To evaluate associations of morphologic features with 5-year visual acuity (VA) in the Comparison of Age-related Macular Degeneration (AMD) Treatments Trials (CATT). DESIGN: Cohort study within a randomized clinical trial. PARTICIPANTS: Participants in CATT. METHODS: Eyes with AMD-associated choroidal neovascularization (CNV) and VA between 20/25 and 20/320 were eligible. Treatment was assigned randomly to ranibizumab or bevacizumab and to 3 dosing regimens for 2 years and was at the ophthalmologists' discretion thereafter...
September 3, 2018: Ophthalmology
Sean P Donahue
PURPOSE: To compare long-term outcomes after bilateral lateral rectus recession (BLRc) or unilateral recess-resect (R&R) for primary treatment of childhood intermittent exotropia (IXT). DESIGN: Multicenter randomized clinical trial PARTICIPANTS: 197 children, age 3 to <11 years, with basic-type IXT, largest deviation by prism and alternate cover test at any distance of 15-40Δ, and near stereoacuity of at least 400 arc-seconds METHODS: Random assignment to BLRc or R&R...
September 3, 2018: Ophthalmology
Julia S Sammons, Erin H Graf, Sara Townsend, Cindy L Hoegg, Sarah A Smathers, Susan E Coffin, Katie Williams, Stephanie L Mitchell, Ursula Nawab, David Munson, Graham Quinn, Gil Binenbaum
PURPOSE: Outbreaks of adenovirus in neonatal intensive care units (NICUs) can lead to widespread transmission and serious adverse outcomes. We describe the investigation, response, and successful containment of an adenovirus outbreak in a NICU associated with contaminated handheld ophthalmologic equipment used during retinopathy of prematurity (ROP) screening. DESIGN: Epidemiologic outbreak investigation. PARTICIPANTS: A total of 23 hospitalized neonates, as well as NICU staff and parents of affected infants...
September 1, 2018: Ophthalmology
Moritz C Daniel, Adam M Dubis, Maria Theodorou, Ana Quartilho, Gillian Adams, John Brookes, Maria Papadopoulos, Peng T Khaw, Annegret H Dahlmann-Noor
OBJECTIVE: To compare Schlemm canal (SC) and trabecular meshwork (TM) in children with healthy eyes and those with and without glaucoma after lensectomy. DESIGN: Cross-sectional observational study PARTICIPANTS: Fifty children age 4 to 16 years with healthy eyes and 48 children post lensectomy (124 healthy and 72 post-lensectomy eyes) METHODS: /Interventions: Anterior segment optical coherence tomography (AS-OCT, Tomey Casia) of the nasal iridocorneal angle, at two levels of accommodative effort (2...
August 30, 2018: Ophthalmology
Susan Y Sun, Katrin Wacker, Keith H Baratz, Sanjay V Patel
PURPOSE: To determine if Scheimpflug tomography can identify subclinical corneal edema in Fuchs endothelial corneal dystrophy (FECD), and to recommend a new classification of FECD for clinical practice and research. DESIGN: Cross-sectional study with follow-up of outcomes. PARTICIPANTS: Ninety-three eyes from 57 subjects with a range of severity of FECD and 74 eyes from 40 subjects with normal corneas. METHODS: Corneas were clinically assessed for FECD and corneal edema by using slit-lamp biomicroscopy, and categorized as having clinically definite edema (obvious visible edema), being suspicious for subclinical edema (possible corneal thickening without obvious edema on slit-lamp examination), or not having edema (no clinical suspicion of edema)...
August 25, 2018: Ophthalmology
Petros Aristodemou, John M Sparrow, Stephen Kaye
PURPOSE: To compare methods for evaluating refractive outcomes after cataract surgery to detect outliers. DESIGN: Case series database study of the evaluation of diagnostic technology. PARTICIPANTS: Consecutive patients who had uneventful cataract operations over a 5-year period. METHODS: The intended and postoperative refractive outcome and differences between these were analyzed as a spherical equivalent, cylinder, and spherocylinder...
August 25, 2018: Ophthalmology
Daniel C Turner, Christopher A Girkin, J Crawford Downs
To determine the magnitude of IOP elevation associated with eye rubbing STUDY DESIGN: Experimental Study SUBJECTS: Three nonhuman primates (NHPs) METHODS: Three young adult male rhesus macaques were briefly anesthetized with ketamine and dexmedetomidine, and antibiotic ointment was placed in both eyes. The anesthetic was immediately reversed with atipamezole, and the animals quickly recovered. IOP was continuously recorded at 500 measurements per second during the experiment using a validated implantable wireless telemetry system; high-definition video was recorded while the NHP rubbed its eyes to remove the ointment, and rubbing events were marked in the IOP data...
August 25, 2018: Ophthalmology
Vuong Nguyen, Vincent Daien, Robyn Guymer, Stephanie Young, Alex Hunyor, Samantha Fraser-Bell, Adrian Hunt, Mark C Gillies, Daniel Barthelmes
PURPOSE: To explore various methods for assessing the early response to vascular endothelial growth factor (VEGF) inhibitors for neovascular age-related macular degeneration and investigate their association with 3 year visual acuity (VA) outcomes. DESIGN: Observational study from a prospectively collected registry. PARTICIPANTS: Treatment-naïve eyes in the Fight Retinal Blindness! outcomes registry that commenced anti-VEGF therapy between 1st January 2007 and 1st March 2014 that received 3 anti-VEGF injections within the first 3 months...
August 24, 2018: Ophthalmology
J Willem L Tideman, Jan Roelof Polling, Vincent W V Jaddoe, Johannes R Vingerling, Caroline C W Klaver
PURPOSE: To identify risk factors for axial length (AL) elongation and incident school myopia. DESIGN: Population-based prospective birth-cohort study. PARTICIPANTS: Four thousand seven hundred thirty-four children examined at 6 and 9 years of age from the Generation R Study in Rotterdam, The Netherlands. METHODS: Axial length and corneal radius (CR) were measured with an IOLMaster 500 and daily life activities and demographic characteristics were obtained by questionnaire...
August 23, 2018: Ophthalmology
Yu Sawada, Makoto Araie, Hitomi Shibata, Makoto Ishikawa, Toyoto Iwata, Takeshi Yoshitomi
PURPOSE: To investigate optic disc margin anatomic features in myopic eyes with open-angle glaucoma (OAG) using spectral-domain (SD) OCT. DESIGN: Cross-sectional study. PARTICIPANTS: Two hundred four eyes of 102 participants with OAG and 106 eyes of 53 participants without glaucoma with axial length of 24 mm or more. METHODS: Radial SD OCT B-scans centered on the optic discs were acquired in each eye, and the SD OCT data were colocalized with the optic disc stereophotographs...
August 22, 2018: Ophthalmology
Jeannette J Yu, Elvira Agrόn, Traci E Clemons, Amitha Domalpally, Freekje van Asten, Tiarnan D Keenan, Catherine Cukras, Emily Y Chew
PURPOSE: To investigate the natural history and genetic associations of drusenoid pigment epithelial detachment (DPED) associated with age-related macular degeneration (AMD). DESIGN: Retrospective analysis of a prospective cohort study. PARTICIPANTS: Of the 4203 Age-Related Eye Disease Study 2 (AREDS2) participants, 391 eyes (325 participants) were identified as having DPED without late AMD at the time of DPED detection. Genetic analyses included 120 white AREDS2 participants and 145 AREDS participants with DPED...
August 21, 2018: Ophthalmology
Hiroshi Nakashima, Yasuaki Iwama, Kensuke Tanioka, Kazuyuki Emi
PURPOSE: To report the incidence of, risk factors for, and characteristics of paracentral acute middle maculopathy (PAMM) after 25-gauge pars plana vitrectomy for proliferative diabetic retinopathy (PDR). DESIGN: Retrospective, consecutive, interventional case series. PARTICIPANTS: Five hundred thirty eyes of 427 patients who underwent primary vitrectomy for PDR from 2013 through 2016. METHODS: The patients underwent measurement of best-corrected visual acuity (BCVA), fundus photography, and OCT before and within 2 weeks after vitrectomy...
August 17, 2018: Ophthalmology
Matthew H Ip, Lien Tat, Minas T Coroneo
No abstract text is available yet for this article.
August 17, 2018: Ophthalmology
Robert G Fante, Ryan Bucsi, Kim Wynkoop
No abstract text is available yet for this article.
August 16, 2018: Ophthalmology
Bianca N Susanna, Nara G Ogata, Fábio B Daga, Carolina N Susanna, Alberto Diniz-Filho, Felipe A Medeiros
PURPOSE: To investigate the associations between intraocular pressure (IOP) measurements obtained by different tonometric methods and rates of visual field loss in a cohort of glaucoma patients followed over time. DESIGN: Prospective observational cohort study. PARTICIPANTS: This study included 213 eyes of 125 glaucomatous patients that were followed for an average of 2.4 ± 0.6 years. METHODS: At each visit, IOP measurements were obtained using Goldmann applanation tonometer (GAT), Ocular Response Analyzer (ORA) corneal-compensated IOP (IOPcc ), and ICare rebound tonometer (RBT)...
August 13, 2018: Ophthalmology
Bénédicte Mj Merle, Johanna M Colijn, Audrey Cougnard-Grégoire, Alexandra P M de Koning-Backus, Marie-Noëlle Delyfer, Jessica C Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H Franco, Jean-François Korobelnik, Caroline C W Klaver, Cécile Delcourt
OBJECTIVE: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced AMD (the symptomatic form of AMD) in two European population-based prospective cohorts. DESIGN: Prospective cohorts: the Rotterdam Study I (RS-I) and the Alienor Study. PARTICIPANTS: 4 446 participants aged ≥55 years from RS-I (The Netherlands) and 550 French adults aged 73 years or older from Alienor Study with complete ophthalmologic and dietary data were included in the present study...
August 13, 2018: Ophthalmology
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