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John D Heiss, Stuart Walbridge, Davis P Argersinger, Christopher S Hong, Abhik Ray-Chaudhury, Russell R Lonser, W Jeffrey Elias, Kareem A Zaghloul
BACKGROUND: Muscimol is a gamma-aminobutyric acid receptor agonist that selectively and temporarily inhibits neurons. Local bolus injection of muscimol has been used experimentally to inhibit neuronal populations within discrete anatomical structures and discern their physiological function. OBJECTIVE: To determine the safety and behavioral effects of convection-enhanced delivery of muscimol into the bilateral subthalamic nuclei (STN) of nonhuman primate rhesus macaques (NHPs)...
June 21, 2018: Neurosurgery
Sandeep S Bhangoo
No abstract text is available yet for this article.
June 21, 2018: Neurosurgery
Tej D Azad, Gerald A Grant
No abstract text is available yet for this article.
June 21, 2018: Neurosurgery
Jock C Lillard, Garrett T Venable, Nickalus R Khan, Ruth G Tatevossian, James Dalton, Brandy N Vaughn, Paul Klimo
BACKGROUND: Pediatric supratentorial ependymomas (SEs) have distinct molecular and behavioral differences from their infratentorial counterparts. OBJECTIVE: To present our experience with pediatric SEs over a 24-yr period. METHODS: Clinical, operative, and radiographic information was abstracted retrospectively. Our primary outcomes were progression-free survival (PFS) and overall survival (OS). Detection of C11orf95-RELA rearrangement was performed using interphase fluorescence in situ hybridization (iFISH)...
June 16, 2018: Neurosurgery
Sophie Dorothee van der Linden, Margriet Maria Sitskoorn, Geert-Jan Maria Rutten, Karin Gehring
BACKGROUND: Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started. OBJECTIVE: To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease...
June 16, 2018: Neurosurgery
Mustafa Q Hameed, David Zurakowski, Mark R Proctor, Scellig S D Stone, Benjamin C Warf, Edward R Smith, Liliana C Goumnerova, Marek Swoboda, Tomer Anor, Joseph R Madsen
BACKGROUND: While a noninvasive flow determination would be desirable in the diagnosis of cerebrospinal fluid shunt malfunction, existing studies have not yet defined a role for thermal flow detection. OBJECTIVE: To evaluate a revised test protocol using a micropumper designed to transiently enhance flow during thermal testing to determine whether thermal detection of flow is associated with progression to shunt revision surgery. METHODS: Eighty-two unique tests were performed in 71 shunts...
June 16, 2018: Neurosurgery
William E Gordon, Andrew J Gienapp, Morgan Jones, L Madison Michael, Paul Klimo
The process of transforming a medical student to a competent neurosurgeon is becoming increasingly scrutinized and formalized. However, there are few data on resident workload.We sought to quantify the workload and educational experience of a junior resident while "on-call."A single resident's on-call log was reviewed from the period of July 1, 2014 to June 30, 2016, corresponding to that resident's postgraduate years 2 and 3. For each patient encounter (ie, consult or admission), information pertaining to the patient's demographics, disease or reason for consult, date/time/location of consult, and need for any neurosurgical intervention within the first 24 hours was collected...
June 14, 2018: Neurosurgery
Jacquelyn MacDonell, Niravkumar Patel, Gregory Fischer, E Clif Burdette, Jiang Qian, Vaibhav Chumbalkar, Goutam Ghoshal, Tamas Heffter, Emery Williams, Matthew Gounis, Robert King, Juliette Thibodeau, Gene Bogdanov, Olivia W Brooks, Erin Langan, Roy Hwang, Julie G Pilitsis
BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience with interstitial focused ultrasound (iFUS) ablations in swine, using MR-guided robotically assisted (MRgRA) delivery...
June 14, 2018: Neurosurgery
Michael Karsy, Christian A Bowers, Jonathan Scoville, Bornali Kundu, Mohammed Atef, J Michael Gee, Jian Guan, William T Couldwell
BACKGROUND: Pituitary adenomas are among the most common primary brain tumors. Recently, overlapping surgery has been curbed in many institutions because of the suggestion there might be more significant adverse events, despite several studies showing that complication rates are equivalent. OBJECTIVE: To assess complications and costs associated with overlapping surgery during the transsphenoidal resection of pituitary adenomas. METHODS: A single-center, retrospective cohort study was performed to evaluate the cases of patients who underwent a transsphenoidal approach for pituitary tumor resection...
June 12, 2018: Neurosurgery
Jai Deep Thakur, Brian Manzi, Amey R Savardekar, Maninder Pal Singh, Richard Menger, Anil Nanda
No abstract text is available yet for this article.
June 11, 2018: Neurosurgery
Gauthier Calluaud, Louis-Marie Terrier, Bertrand Mathon, Christophe Destrieux, Stéphane Velut, Patrick François, Ilyess Zemmoura, Aymeric Amelot
BACKGROUND: Twenty percent of all brain metastases (BM) occur in the posterior fossa (PF). Radiotherapy sometimes associated with surgical resection remains the therapeutic option, while Karnovsky performance status and graded prognostic assessment (GPA) are the best preoperative survival prognostic factors. OBJECTIVE: To explore the prognostic role of peritumoral brain edema in the PF, which has never been explored though its role in supratentorial BM has been debated...
June 11, 2018: Neurosurgery
Francesco Sala, Stanley A Skinner, Jeffrey E Arle, Shlomi Constantini, Vedran Deletis, Karl F Kothbauer, David B MacDonald, Jay Shils, Francisco Soto, Andrea Szelenyi
No abstract text is available yet for this article.
June 11, 2018: Neurosurgery
Yuval Shapira, Vanessa Sammons, Joanne Forden, Gui Fang Guo, Alexander Kipp, Jill Girgulis, Tanmay Mishra, Jacob Daniel de Villers Alant, Rajiv Midha
BACKGROUND: Brief electrical stimulation (ES) therapy to the nerve may improve outcome in lacerated, repaired nerves. However, most human nerve injuries leave the nerve in continuity with variable and often poor functional recovery from incomplete axon regeneration and reinnervation. OBJECTIVE: To evaluate the effect of brief ES in an experimental model for neuroma-in-continuity (NIC) injuries in rodents. METHODS: Lewis rats were randomly assigned to 1 of 4 groups: NIC injury immediately followed by brief (1 h) ES; NIC injury without ES; sham-operated controls; sciatic nerve transection without repair...
June 11, 2018: Neurosurgery
Mark N Hadley, Christopher D Shank, Curtis J Rozzelle, Beverly C Walters
No abstract text is available yet for this article.
June 11, 2018: Neurosurgery
Aladine A Elsamadicy, Xinru Ren, Hanna Kemeny, Lefko Charalambous, Amanda R Sergesketter, Shervin Rahimpour, Theresa Williamson, C Rory Goodwin, Muhammad M Abd-El-Barr, Oren N Gottfried, Jichun Xie, Shivanand P Lad
BACKGROUND: Unplanned hospital readmissions contribute significantly to soaring national healthcare expenditures. To alleviate this burden, Centers for Medicare and Medicaid Services implemented initiatives to penalize hospitals for unplanned 30-d hospital readmissions. There is a paucity of data identifying patient risk factors independently associated with 30- and 90-d readmissions. OBJECTIVE: To investigate similarities in patient risk factors associated with 30- and 90-d unplanned readmissions following elective lumbar spine surgery...
June 11, 2018: Neurosurgery
Robin Babadjouni, Timothy Wen, Daniel A Donoho, Ian A Buchanan, Steven Y Cen, Rick A Friedman, Arun Amar, Jonathan J Russin, Steven L Giannotta, William J Mack, Frank J Attenello
BACKGROUND: Hospital readmissions are commonly linked to elevated health care costs, with significant financial incentive introduced by the Affordable Care Act to reduce readmissions. OBJECTIVE: To study the association between patient, hospital, and payer factors with national rate of readmission in acoustic neuroma surgery. METHODS: All adult inpatients undergoing surgery for acoustic neuroma in the newly introduced Nationwide Readmissions Database from 2013 to 2014 were included...
June 8, 2018: Neurosurgery
Julia R Schneider, Kay O Kulason, Muhammad Babar Khan, Timothy G White, Kevin Kwan, Lukas Faltings, Andrew J Kobets, Shamik Chakraborty, Jason A Ellis, Rafael A Ortiz, Christopher G Filippi, David J Langer, John A Boockvar
No abstract text is available yet for this article.
June 8, 2018: Neurosurgery
Jimmy C Yang, Andrew S Venteicher, Matthew J Koch, Christopher J Stapleton, Gabriel N Friedman, Emma M Venteicher, John H Shin
BACKGROUND AND IMPORTANCE: Myopericytoma is an emerging class of neoplasm originating from the perivascular myoid cellular environment, previously classified as a variant of hemangiopericytoma. Most reported myopericytomas are found in soft tissues of the extremities; however, infrequent cases are described involving the central nervous system. Intracranial myopericytoma remains rare. Here, we describe the first report of myopericytoma occurring at the cervicomedullary junction in close proximity to the vertebral artery, mimicking a vascular lesion...
June 8, 2018: Neurosurgery
Michelle L Allen, Tobias Kulik, Salah G Keyrouz, Rajat Dhar
BACKGROUND: Induced hypertension (IH) remains the mainstay of medical management for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). However, raising blood pressure above normal levels may be associated with systemic and neurological complications, of which posterior reversible encephalopathy syndrome (PRES) has been increasingly recognized. OBJECTIVE: To ascertain the frequency and predisposing factors for PRES during IH therapy. METHODS: We identified 68 patients treated with IH from 345 SAH patients over a 3-yr period...
June 8, 2018: Neurosurgery
Satoshi Hori, Daina Kashiwazaki, Shusuke Yamamoto, Güliz Acker, Marcus Czabanka, Naoki Akioka, Naoya Kuwayama, Peter Vajkoczy, Satoshi Kuroda
BACKGROUND: Fragile, dilated moyamoya vessels are the main source of hemorrhagic stroke in moyamoya disease (MMD). However, the prevalence of hemorrhagic stroke largely differs between Asian and western countries, although the underlying pathophysiology has not been clarified. OBJECTIVE: To systematically analyze the difference of collateral angioarchitectures between Japanese and European Caucasians with MMD. METHODS: This study included 71 patients with MMD, including Japanese (n = 41) and European Caucasians (n = 30)...
June 8, 2018: Neurosurgery
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