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Neurology

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https://www.readbyqxmd.com/read/29030457/adding-quantitative-muscle-mri-to-the-fshd-clinical-trial-toolbox
#1
Karlien Mul, Sanne C C Vincenten, Nicol C Voermans, Richard J L F Lemmers, Patrick J van der Vliet, Silvère M van der Maarel, George W Padberg, Corinne G C Horlings, Baziel G M van Engelen
OBJECTIVE: To add quantitative muscle MRI to the clinical trial toolbox for facioscapulohumeral muscular dystrophy (FSHD) by correlating it to clinical outcome measures in a large cohort of genetically and clinically well-characterized patients with FSHD comprising the entire clinical spectrum. METHODS: Quantitative MRI scans of leg muscles of 140 patients with FSHD1 and FSHD2 were assessed for fatty infiltration and TIRM hyperintensities and were correlated to multiple clinical outcome measures...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030456/association-between-percent-decline-in-serum-total-homocysteine-and-risk-of-first-stroke
#2
Xiao Huang, Youbao Li, Ping Li, Jianping Li, Huihui Bao, Yan Zhang, Binyan Wang, Ningling Sun, Jiguang Wang, Mingli He, Delu Yin, Genfu Tang, Yundai Chen, Yiming Cui, Yining Huang, Fan Fan Hou, Xianhui Qin, Yong Huo, Xiaoshu Cheng
OBJECTIVE: To examine whether a change in serum total homocysteine (tHcy) levels is associated with first stroke risk in a post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT). METHODS: We analyzed 16,867 participants of the CSPPT with tHcy measurements at both baseline and exit visits. The primary outcome was first stroke. The secondary outcome was a composite of cardiovascular events consisting of cardiovascular death, myocardial infarction, and stroke...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030455/optimal-deep-brain-stimulation-site-and-target-connectivity-for-chronic-cluster-headache
#3
Harith Akram, Sarah Miller, Susie Lagrata, Marwan Hariz, John Ashburner, Tim Behrens, Manjit Matharu, Ludvic Zrinzo
OBJECTIVE: To investigate the mechanism of action of deep brain stimulation for refractory chronic cluster headache and the optimal target within the ventral tegmental area. METHODS: Seven patients with refractory chronic cluster headache underwent high spatial and angular resolution diffusion MRI preoperatively. MRI-guided and MRI-verified electrode implantation was performed unilaterally in 5 patients and bilaterally in 2. Volumes of tissue activation were generated around active lead contacts with a finite-element model...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030454/infliximab-for-the-treatment-of-cns-sarcoidosis-a-multi-institutional-series
#4
Jeffrey M Gelfand, Michael J Bradshaw, Barney J Stern, David B Clifford, Yunxia Wang, Tracey A Cho, Laura L Koth, Stephen L Hauser, Jason Dierkhising, NgocHanh Vu, Subramaniam Sriram, Harold Moses, Francesca Bagnato, Jeffrey A Kaufmann, Deidre J Ammah, Tsion H Yohannes, Mark J Hamblin, Nagagopal Venna, Ari J Green, Siddharama Pawate
OBJECTIVE: To describe clinical and imaging responses in neurosarcoidosis to infliximab, a monoclonal antibody against tumor necrosis factor-α. METHODS: Investigators at 6 US centers retrospectively identified patients with CNS sarcoidosis treated with infliximab, including only patients with definite or probable neurosarcoidosis following rigorous exclusion of other causes. RESULTS: Of 66 patients with CNS sarcoidosis (27 definite, 39 probable) treated with infliximab for a median of 1...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030453/gaba-alterations-in-pediatric-sport-concussion
#5
Seth D Friedman, Andrew V Poliakov, Christopher Budech, Dennis W W Shaw, David Breiger, Thomas Jinguji, Brian Krabak, David Coppel, Tressa Mattioli Lewis, Samuel Browd, Jeffrey G Ojemann
OBJECTIVE: To evaluate whether frontal-lobe magnetic resonance spectroscopy measures of γ-aminobutyric acid (GABA) would be altered in a sample of adolescents scanned after sport concussion because mild traumatic brain injury is often associated with working memory problems. METHODS: Eleven adolescents (age 14-17 years) who had sustained a first-time sport concussion were studied with MRI/magnetic resonance spectroscopy within 23 to 44 days after injury (mean 30...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030452/longitudinal-csf-biomarkers-in-patients-with-early-parkinson-disease-and-healthy-controls
#6
Brit Mollenhauer, Chelsea J Caspell-Garcia, Christopher S Coffey, Peggy Taylor, Leslie M Shaw, John Q Trojanowski, Andy Singleton, Mark Frasier, Kenneth Marek, Douglas Galasko
OBJECTIVE: To analyze longitudinal levels of CSF biomarkers in drug-naive patients with Parkinson disease (PD) and healthy controls (HC), examine the extent to which these biomarker changes relate to clinical measures of PD, and identify what may influence them. METHODS: CSF α-synuclein (α-syn), total and phosphorylated tau (t- and p-tau), and β-amyloid 1-42 (Aβ42) were measured at baseline and 6 and 12 months in 173 patients with PD and 112 matched HC in the international multicenter Parkinson's Progression Marker Initiative...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030451/weighting-and-standardization-of-frequencies-to-determine-prevalence-of-ad-imaging-biomarkers
#7
Rosebud O Roberts, David S Knopman, Jeremy A Syrjanen, Jeremiah A Aakre, Maria Vassilaki, Walter K Kremers, Michelle M Mielke, Mary M Machulda, Jonathan Graff-Radford, Yonas E Geda, Prashanthi Vemuri, Val Lowe, Clifford R Jack, Ronald C Petersen
OBJECTIVE: To estimate the prevalence of elevated brain amyloid and reduced cortical thickness (as a marker for neurodegeneration) in a defined population. METHODS: Mayo Clinic Study of Aging participants underwent MRI to assess a composite Alzheimer disease (AD) signature cortical thickness measure and PET to assess brain amyloid accumulation. Participants were characterized as having elevated amyloid (A+/A-), reduced cortical thickness (N+/N-), and A+N+, A+N-, A-N+, or A-N-...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29030450/effect-of-concussion-and-blast-exposure-on-symptoms-after-military-deployment
#8
Jack W Tsao, Lauren A Stentz, Minoo Rouhanian, Robin S Howard, Briana N Perry, F Jay Haran, Paul F Pasquina, Mikias Wolde, Carolyn E Taylor, Radhames Lizardo, Scott Liu, Eusebio Flores, Alia H Creason, Katalina Sher
OBJECTIVE: To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms. METHODS: A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan. RESULTS: A total of 2,612 Marines (median age 22 years) completed the survey. Of those, 2,320 (88.9%) reported exposure to ≥1 blast during their current and/or prior deployments...
October 13, 2017: Neurology
https://www.readbyqxmd.com/read/29021359/increasing-prevalence-of-vascular-risk-factors-in-patients-with-stroke-a-call-to-action
#9
Fadar Oliver Otite, Nicholas Liaw, Priyank Khandelwal, Amer M Malik, Jose G Romano, Tatjana Rundek, Ralph L Sacco, Seemant Chaturvedi
OBJECTIVE: To evaluate trends in prevalence of cardiovascular risk factors (hypertension, diabetes, dyslipidemia, smoking, and drug abuse) and cardiovascular diseases (carotid stenosis, chronic renal failure [CRF], and coronary artery disease [CAD]) in acute ischemic stroke (AIS) in the United States. METHODS: We used the 2004-2014 National Inpatient Sample to compute weighted prevalence of each risk factor in hospitalized patients with AIS and used joinpoint regression to evaluate change in prevalence over time...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021358/big-data-trends-in-stroke-epidemiology-in-the-united-states-but-are-they-good-data
#10
EDITORIAL
Shyam Prabhakaran
No abstract text is available yet for this article.
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021357/radiographic-and-symptomatic-brain-ischemia-in-cea-and-cas-a-systematic-review-and-meta-analysis
#11
Sung-Min Cho, Abhishek Deshpande, Vinay Pasupuleti, Adrian V Hernandez, Ken Uchino
OBJECTIVE: In a systematic review, we compared ratio of new periprocedural radiographic brain ischemia (RBI) to the number of strokes and TIAs among patients undergoing carotid endarterectomy (CEA) and carotid artery stenting (CAS). METHODS: We searched 5 databases for entries related to brain ischemia in CEA or CAS from inception through September 2015. We included articles with CEA or CAS and systematic performance of preprocedural and postprocedural brain MRI and reporting of RBI and stroke incidence...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021356/volumetric-brain-changes-in-migraineurs-from-the-general-population
#12
Inge H Palm-Meinders, Enrico B Arkink, Hille Koppen, Souad Amlal, Gisela M Terwindt, Lenore J Launer, Mark A van Buchem, Michel D Ferrari, Mark C Kruit
OBJECTIVE: To assess volumetric brain changes in migraineurs from the general population compared with controls. METHODS: Structural brain changes in migraineurs from the general population-based MRI Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis (CAMERA)-2 observational cohort study were assessed by state-of-the-art voxel-based morphometry. T1-weighted MRIs of 84 migraineurs (52 with aura, 32 without aura) and 35 headache-free controls were evaluated...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021355/population-based-study-of-home-time-by-stroke-type-and-correlation-with-modified-rankin-score
#13
Amy Y X Yu, Edwin Rogers, Meng Wang, Tolulope T Sajobi, Shelagh B Coutts, Bijoy K Menon, Michael D Hill, Eric E Smith
OBJECTIVE: To describe home-time, stratified by stroke type, in a complete population and to determine its correlation with modified Rankin Scale (mRS) scores. METHODS: We used linked administrative data to derive home-time in all patients admitted for a cerebrovascular event in Alberta, Canada, between 2012 and 2016. Home-time is the number of days spent outside a health institution in the first 90 days after index hospitalization. We used negative binomial regression, adjusted for age, sex, Charlson comorbidity index, and hospital location, to determine the association between home-time and stroke type...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021354/trmt5-mutations-are-associated-with-features-of-complex-hereditary-spastic-paraparesis
#14
Mark A Tarnopolsky, Lauren Brady, Martine Tetreault
No abstract text is available yet for this article.
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021353/longitudinal-decline-of-driving-safety-in-parkinson-disease
#15
Ergun Y Uc, Matthew Rizzo, Amy M J O'Shea, Steven W Anderson, Jeffrey D Dawson
OBJECTIVE: To longitudinally assess and predict on-road driving safety in Parkinson disease (PD). METHODS: Drivers with PD (n = 67) and healthy controls (n = 110) drove a standardized route in an instrumented vehicle and were invited to return 2 years later. A professional driving expert reviewed drive data and videos to score safety errors. RESULTS: At baseline, drivers with PD performed worse on visual, cognitive, and motor tests, and committed more road safety errors compared to controls (median PD 38...
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/29021352/successful-motor-mapping-with-transcranial-magnetic-stimulation-in-an-infant-a-case-report
#16
Shalini Narayana, Basanagoud Mudigoudar, Abbas Babajani-Feremi, Asim F Choudhri, Frederick A Boop
No abstract text is available yet for this article.
October 11, 2017: Neurology
https://www.readbyqxmd.com/read/28986416/subjective-cognitive-decline-and-%C3%AE-amyloid-burden-predict-cognitive-change-in-healthy-elderly
#17
Jacob W Vogel, Monika Varga Doležalová, Renaud La Joie, Shawn M Marks, Henry D Schwimmer, Susan M Landau, William J Jagust
OBJECTIVE: To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline. METHODS: One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of 4 years. SCD and affective measures were generated from the Geriatric Depression Scale (GDS) with factor analysis on data from a larger set of 347 healthy, nondepressed (GDS <11) elderly individuals...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28986415/clinical-outcomes-of-asleep-vs-awake-deep-brain-stimulation-for-parkinson-disease
#18
Matthew A Brodsky, Shannon Anderson, Charles Murchison, Mara Seier, Jennifer Wilhelm, Aaron Vederman, Kim J Burchiel
OBJECTIVE: To compare motor and nonmotor outcomes at 6 months of asleep deep brain stimulation (DBS) for Parkinson disease (PD) using intraoperative imaging guidance to confirm electrode placement vs awake DBS using microelectrode recording to confirm electrode placement. METHODS: DBS candidates with PD referred to Oregon Health & Science University underwent asleep DBS with imaging guidance. Six-month outcomes were compared to those of patients who previously underwent awake DBS by the same surgeon and center...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28986414/prediction-of-work-resumption-and-sustainability-up-to-1-year-after-mild-traumatic-brain-injury
#19
Myrthe E de Koning, Myrthe E Scheenen, Harm J van der Horn, Marieke E Timmerman, Gerard Hageman, Gerwin Roks, Jacoba M Spikman, Joukje van der Naalt
OBJECTIVE: To study return to work (RTW) after mild traumatic brain injury (mTBI) at several intervals after injury and to predict RTW on the basis of occupational factors in addition to demographic, personality, and injury-related factors at 6 and 12 months after injury. METHODS: This was a prospective cohort study (UPFRONT study, n = 1,151) of patients with mTBI admitted to the emergency department. Patients received questionnaires at 2 weeks and 3, 6, and 12 months after injury...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28986413/is-virtual-reality-a-useful-adjunct-to-rehabilitation-after-spinal-cord-injury
#20
Richard Rammo, Jason M Schwalb
No abstract text is available yet for this article.
October 6, 2017: Neurology
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