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Neurology

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https://www.readbyqxmd.com/read/28724590/long-term-antithrombotic-treatment-in-intracranial-hemorrhage-survivors-with-atrial-fibrillation
#1
Eleni Korompoki, Filippos T Filippidis, Peter B Nielsen, Angela Del Giudice, Gregory Y H Lip, Joji B Kuramatsu, Hagen B Huttner, Jiming Fang, Sam Schulman, Joan Martí-Fàbregas, Celine S Gathier, Anand Viswanathan, Alessandro Biffi, Daniela Poli, Christian Weimar, Uwe Malzahn, Peter Heuschmann, Roland Veltkamp
OBJECTIVE: To perform a systematic review and meta-analysis of studies reporting recurrent intracranial hemorrhage (ICH) and ischemic stroke (IS) in ICH survivors with atrial fibrillation (AF) during long-term follow-up. METHODS: A comprehensive literature search including MEDLINE, EMBASE, Cochrane library, clinical trials registry was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We considered studies capturing outcome events (ICH recurrence and IS) for ≥3 months and treatment exposure to vitamin K antagonists (VKAs), antiplatelet agents (APAs), or no antithrombotic medication (no-ATM)...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724589/affective-prosody-in-frontotemporal-dementia-the-importance-of-pitching-it-right
#2
EDITORIAL
Cristian E Leyton, Argye E Hillis
No abstract text is available yet for this article.
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724588/automatic-measurement-of-prosody-in-behavioral-variant-ftd
#3
Naomi Nevler, Sharon Ash, Charles Jester, David J Irwin, Mark Liberman, Murray Grossman
OBJECTIVE: To help understand speech changes in behavioral variant frontotemporal dementia (bvFTD), we developed and implemented automatic methods of speech analysis for quantification of prosody, and evaluated clinical and anatomical correlations. METHODS: We analyzed semi-structured, digitized speech samples from 32 patients with bvFTD (21 male, mean age 63 ± 8.5, mean disease duration 4 ± 3.1 years) and 17 matched healthy controls (HC). We automatically extracted fundamental frequency (f0, the physical property of sound most closely correlating with perceived pitch) and computed pitch range on a logarithmic scale (semitone) that controls for individual and sex differences...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724587/florbetapir-imaging-in-cerebral-amyloid-angiopathy-related-hemorrhages
#4
Nicolas Raposo, Mélanie Planton, Patrice Péran, Pierre Payoux, Fabrice Bonneville, Aicha Lyoubi, Jean François Albucher, Blandine Acket, Anne Sophie Salabert, Jean Marc Olivot, Anne Hitzel, François Chollet, Jérémie Pariente
OBJECTIVE: To assess whether (18)F-florbetapir, a PET amyloid tracer, could bind vascular amyloid in cerebral amyloid angiopathy (CAA) by comparing cortical florbetapir retention during the acute phase between patients with CAA-related lobar intracerebral hemorrhage (ICH) and patients with hypertension-related deep ICH. METHODS: Patients with acute CAA-related lobar ICH were prospectively enrolled and compared with patients with deep ICH. (18)F-florbetapir PET, brain MRI, and APOE genotype were obtained for all participants...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724586/cardiovascular-health-in-young-adulthood-and-structural-brain-mri-in-midlife-the-cardia-study
#5
Michael P Bancks, Norrina B Allen, Prachi Dubey, Lenore J Launer, Donald M Lloyd-Jones, Jared P Reis, Stephen Sidney, Yuichiro Yano, Pamela J Schreiner
OBJECTIVE: To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure. METHODS: We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0-14) at baseline (aged 18-30 years in 1985-1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724585/effect-of-gluten-free-diet-on-cerebellar-mr-spectroscopy-in-gluten-ataxia
#6
Marios Hadjivassiliou, Richard A Grünewald, David S Sanders, Priya Shanmugarajah, Nigel Hoggard
OBJECTIVE: To evaluate the effect of gluten free diet (GFD) on magnetic resonance spectroscopy (MRS) of the cerebellum in patients with gluten ataxia (GA). METHODS: Patients with GA, defined as sporadic ataxia with positive antigliadin antibodies in the absence of an alternative cause, routinely undergo MRS at baseline and after the introduction of GFD as part of their clinical care. We present our experience of the effect of GFD on MRS of the cerebellum. RESULTS: A total of 117 consecutive patients with GA were included in this report...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724584/vcp-related-multisystem-proteinopathy-presenting-as-early-onset-parkinson-disease
#7
Martin Regensburger, Matthias Türk, Axel Pagenstecher, Rolf Schröder, Jürgen Winkler
No abstract text is available yet for this article.
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724583/anoctamins-tmem16-proteins-functions-and-involvement-in-neurologic-disease
#8
Eduardo E Benarroch
No abstract text is available yet for this article.
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724582/pretreatment-seizure-semiology-in-childhood-absence-epilepsy
#9
Sudha Kilaru Kessler, Shlomo Shinnar, Avital Cnaan, Dennis Dlugos, Joan Conry, Deborah G Hirtz, Fengming Hu, Chunyan Liu, Eli M Mizrahi, Solomon L Moshé, Peggy Clark, Tracy A Glauser
OBJECTIVE: To determine seizure semiology in children with newly diagnosed childhood absence epilepsy and to evaluate associations with short-term treatment outcomes. METHODS: For participants enrolled in a multicenter, randomized, double-blind, comparative-effectiveness trial, semiologic features of pretreatment seizures were analyzed as predictors of treatment outcome at the week 16 to 20 visit. RESULTS: Video of 1,932 electrographic absence seizures from 416 participants was evaluated...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724581/mri-evidence-of-acute-inflammation-in-leukocortical-lesions-of-patients-with-early-multiple-sclerosis
#10
Josefina Maranzano, David A Rudko, Kunio Nakamura, Stuart Cook, Diego Cadavid, Leo Wolansky, Douglas L Arnold, Sridar Narayanan
OBJECTIVE: To identify gadolinium-enhancing lesions affecting the cortex of patients with early multiple sclerosis (MS) and to describe the frequency and evolution of these lesions. METHODS: We performed a retrospective, observational, longitudinal analysis of MRI scans collected as part of the Betaseron vs Copaxone in Multiple Sclerosis with Triple-Dose Gadolinium and 3T MRI Endpoints (BECOME) study. Seventy-five patients with early-stage MS were scanned monthly, over a period of 12-24 months, using 3T MRI after administration of triple-dose gadolinium...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28710330/assessment-of-the-interaction-of-age-and-sex-on-90-day-outcome-after-intracerebral-hemorrhage
#11
Michael L James, Carl D Langefeld, Padmini Sekar, Charles J Moomaw, Mitchell S V Elkind, Bradford B Worrall, Kevin N Sheth, Sharyl R Martini, Jennifer Osborne, Daniel Woo
OBJECTIVE: Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective effects of gonadal hormones. METHODS: Clinical and radiographic data from participants in the Ethnic/Racial Variations of Intracerebral Hemorrhage study and the Genetic and Environmental Risk Factors for Hemorrhagic Stroke study prior to December 2013 were used...
July 14, 2017: Neurology
https://www.readbyqxmd.com/read/28710329/open-label-trial-of-ranolazine-for-the-treatment-of-myotonia-congenita
#12
W David Arnold, David Kline, Alan Sanderson, Ahmed A Hawash, Amy Bartlett, Kevin R Novak, Mark M Rich, John T Kissel
OBJECTIVE: To determine open-label, pilot study whether ranolazine could improve signs and symptoms of myotonia and muscle stiffness in patients with myotonia congenita (MC). METHODS: Thirteen participants were assessed at baseline and 2, 4, and 5 weeks. Ranolazine was started after baseline assessment (500 mg twice daily), increased as tolerated after week 2 (1,000 mg twice daily), and maintained until week 4. Outcomes included change from baseline to week 4 in self-reported severity of symptoms (stiffness, weakness, and pain), Timed Up and Go (TUG), hand grip and eyelid myotonia, and myotonia on EMG...
July 14, 2017: Neurology
https://www.readbyqxmd.com/read/28701502/wrist-sensor-reveals-sympathetic-hyperactivity-and-hypoventilation-before-probable-sudep
#13
Rosalind W Picard, Matteo Migliorini, Chiara Caborni, Francesco Onorati, Giulia Regalia, Daniel Friedman, Orrin Devinsky
No abstract text is available yet for this article.
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701501/blood-pressure-reduction-and-noncontrast-ct-markers-of-intracerebral-hemorrhage-expansion
#14
Andrea Morotti, Gregoire Boulouis, Javier M Romero, H Bart Brouwers, Michael J Jessel, Anastasia Vashkevich, Kristin Schwab, Mohammad Rauf Afzal, Christy Cassarly, Steven M Greenberg, Reneé Hebert Martin, Adnan I Qureshi, Jonathan Rosand, Joshua N Goldstein
OBJECTIVE: To validate various noncontrast CT (NCCT) predictors of hematoma expansion in a large international cohort of ICH patients and investigate whether intensive blood pressure (BP) treatment reduces ICH growth and improves outcome in patients with these markers. METHODS: We analyzed patients enrolled in the Antihypertensive Treatment of Acute Cerebral Hemorrhage II (ATACH-II) randomized controlled trial. Participants were assigned to intensive (systolic BP <140 mm Hg) vs standard (systolic BP <180 mm Hg) treatment within 4...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701500/assessing-structure-and-function-of-myelin-in-cervical-spondylotic-myelopathy-evidence-of-demyelination
#15
Hanwen Liu, Erin L MacMillian, Catherine R Jutzeler, Emil Ljungberg, Alex L MacKay, Shannon H Kolind, Burkhard Mädler, David K B Li, Marcel F Dvorak, Armin Curt, Cornelia Laule, John L K Kramer
PURPOSE: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC)...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701499/breastfeeding-ovulatory-years-and-risk-of-multiple-sclerosis
#16
Annette Langer-Gould, Jessica B Smith, Kerstin Hellwig, Edlin Gonzales, Samantha Haraszti, Corinna Koebnick, Anny Xiang
OBJECTIVE: To determine whether women who breastfeed their infants longer or have fewer ovulatory years are at lower risk of developing multiple sclerosis (MS). METHODS: We recruited women with newly diagnosed MS or its precursor, clinically isolated syndrome (CIS) (n = 397), and matched controls (n = 433) into the MS Sunshine Study from the membership of Kaiser Permanente Southern California. A structured in-person questionnaire was administered to collect the behavioral (pregnancies, breastfeeding, hormonal contraceptive use) and biological (age at menarche and menopause, amenorrhea) factors to make up ovulatory years...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701498/phosphodiesterase-4-rethinking-cognition-in-parkinson-disease
#17
EDITORIAL
Claudia Jacova, Stewart A Factor
No abstract text is available yet for this article.
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701497/teaching-neurology-to-medical-students-with-a-simplified-version-of-team-based-learning
#18
Jochen Brich, Meike Jost, Peter Brüstle, Marianne Giesler, Michel Rijntjes
OBJECTIVE: To compare the effect of a simplified version of team-based learning (sTBL), an active learning/small group instructional strategy, with that of the traditionally used small group interactive seminars on the acquisition of knowledge and clinical reasoning (CR) skills. METHODS: Third- and fourth-year medical students (n = 122) were randomly distributed into 2 groups. A crossover design was used in which 2 neurologic topics were taught by sTBL and 2 by small group interactive seminars...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701496/the-spectrum-of-mild-traumatic-brain-injury-a-review
#19
REVIEW
Andrew R Mayer, Davin K Quinn, Christina L Master
OBJECTIVE: This review provides an in-depth overview of diagnostic schema and risk factors influencing recovery during the acute, subacute (operationally defined as up to 3 months postinjury), and chronic injury phases across the full spectrum of individuals (e.g., athletes to neurosurgery patients) with mild traumatic brain injury (mTBI). Particular emphasis is placed on the complex differential diagnoses for patients with prolonged postconcussive symptoms. METHODS: Select literature review and synthesis...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701495/neurodegenerative-and-psychiatric-diseases-among-families-with-amyotrophic-lateral-sclerosis
#20
Elisa Longinetti, Daniela Mariosa, Henrik Larsson, Weimin Ye, Caroline Ingre, Catarina Almqvist, Paul Lichtenstein, Fredrik Piehl, Fang Fang
OBJECTIVE: To estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families. METHODS: We conducted a register-based nested case-control study during 1990-2013 in Sweden to assess whether patients with ALS had higher risks of other neurodegenerative and psychiatric diseases before diagnosis. We included 3,648 patients with ALS and 36,480 age-, sex-, and county of birth-matched population controls...
July 12, 2017: Neurology
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