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Neurology

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https://www.readbyqxmd.com/read/29925552/don-t-ask-don-t-tell-impulse-control-disorders-in-pd
#1
EDITORIAL
Laura S Boylan, Vladimir S Kostić
No abstract text is available yet for this article.
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29925551/gray-matter-volume-modifications-in-migraine-a-cross-sectional-and-longitudinal-study
#2
Roberta Messina, Maria A Rocca, Bruno Colombo, Elisabetta Pagani, Andrea Falini, Peter J Goadsby, Massimo Filippi
OBJECTIVE: To explore cross-sectional and longitudinal gray matter (GM) volume changes in patients with migraine and their association with patients' clinical characteristics and disease activity. METHODS: Brain T2-weighted and 3-dimensional T1-weighted scans were acquired from 73 episodic migraineurs and 46 age- and sex-matched nonmigraine controls at baseline. Twenty-four migraineurs and 25 controls agreed to be reexamined after a mean follow-up of 4 years. Using a general linear model and SPM12, a whole-brain analysis was performed to assess GM volume modifications...
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29925550/three-tesla-mri-does-not-improve-the-diagnosis-of-multiple-sclerosis-a-multicenter-study
#3
Marloes H J Hagens, Jessica Burggraaff, Iris D Kilsdonk, Marlieke L de Vos, Niamh Cawley, Emilia Sbardella, Michaela Andelova, Michael Amann, Johanna M Lieb, Patrizia Pantano, Birgit I Lissenberg-Witte, Joep Killestein, Celia Oreja-Guevara, Olga Ciccarelli, Claudio Gasperini, Carsten Lukas, Mike P Wattjes, Frederik Barkhof
OBJECTIVE: In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS: We recruited 66 patients with CIS within 6 months from symptom onset and 26 healthy controls in 6 MS centers. All participants underwent 1.5T and 3T brain and spinal cord MRI at baseline according to local optimized protocols and the MAGNIMS guidelines...
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29925549/longitudinal-analysis-of-impulse-control-disorders-in-parkinson-disease
#4
Jean-Christophe Corvol, Fanny Artaud, Florence Cormier-Dequaire, Olivier Rascol, Franck Durif, Pascal Derkinderen, Ana-Raquel Marques, Frédéric Bourdain, Jean-Philippe Brandel, Fernando Pico, Lucette Lacomblez, Cecilia Bonnet, Christine Brefel-Courbon, Fabienne Ory-Magne, David Grabli, Stephan Klebe, Graziella Mangone, Hana You, Valérie Mesnage, Pei-Chen Lee, Alexis Brice, Marie Vidailhet, Alexis Elbaz
OBJECTIVE: To investigate the longitudinal dose-effect relationship between dopamine replacement therapy and impulse control disorders (ICDs) in Parkinson disease (PD). METHODS: We used data from a multicenter longitudinal cohort of consecutive patients with PD with ≤5 years' disease duration at baseline followed up annually up to 5 years. ICDs were evaluated during face-to-face semistructured interviews with movement disorder specialists. Generalized estimating equations and Poisson models with robust variance were used to study the association between several time-dependent definitions of dopamine agonist (DA) use, taking dose and duration of treatment into account, and ICDs at each visit...
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29925548/evaluating-depression-and-suicidality-in-tetrabenazine-users-with-huntington-disease
#5
Jordan L Schultz, Annie Killoran, Peg C Nopoulos, Chloe C Chabal, David J Moser, John A Kamholz
OBJECTIVE: To determine whether tetrabenazine (TBZ) use is associated with an increased incidence of depression and/or suicidal ideation. METHODS: In this retrospective cross-sectional study of the Enroll-HD database, we used multiple logistic regression analyses to determine whether TBZ use is associated with an increased incidence of depression and/or suicidal ideation. For both dependent variables (depression and suicidality), separate analyses were conducted on (1) all participants, (2) only participants with a history of depression, and (3) only participants with no history of depression...
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29925547/outcome-after-seizure-recurrence-on-antiepileptic-drug-withdrawal-following-temporal-lobectomy
#6
Chaturbhuj Rathore, Malcolm K Jeyaraj, Gopal K Dash, Pandurang Wattamwar, Neeraj Baheti, Sankara P Sarma, Kurupath Radhakrishnan
OBJECTIVE: To study the long-term outcome following seizure recurrence on antiepileptic drug (AED) withdrawal after anterior temporal lobectomy for mesial temporal lobe epilepsy. METHODS: We retrospectively studied the AED profile of patients who had a minimum of 5 years of postoperative follow-up after anterior temporal lobectomy for mesial temporal lobe epilepsy. Only those patients with hippocampal sclerosis or normal MRI were included. AED withdrawal was initiated at 3 months in patients on ≥2 drugs and at 1 year for patients on a single drug...
June 20, 2018: Neurology
https://www.readbyqxmd.com/read/29907609/effects-of-centralizing-acute-stroke-services-a-prospective-cohort-study
#7
Sidsel Hastrup, Soren P Johnsen, Thorkild Terkelsen, Heidi H Hundborg, Paul von Weitzel-Mudersbach, Claus Z Simonsen, Niels Hjort, Anette T Møller, Thomas Harbo, Marika S Poulsen, Noella Ruiz de Morales Ayudarte, Dorte Damgaard, Grethe Andersen
OBJECTIVE: To investigate the effects of centralizing the acute stroke services in the Central Denmark Region (CDR). METHODS: The CDR (1.3 million inhabitants) centralized acute stroke care from 6 to 2 designated acute stroke units with 7-day outpatient clinics. We performed a prospective "before-and-after" cohort study comparing all strokes from the CDR with strokes in the rest of Denmark to discover underlying general trends, adopting a difference-in-differences approach...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29907608/noninvasive-vagus-nerve-stimulation-as-acute-therapy-for-migraine-the-randomized-presto-study
#8
Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
OBJECTIVE: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS: A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants were to repeat treatment if pain had not improved in 15 minutes...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29907607/comment-noninvasive-neurostimulation-for-migraine-should-be-part-of-the-general-neurologist-s-therapeutic-armamentarium
#9
Richard B Lipton, Peter J Goadsby
No abstract text is available yet for this article.
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29907606/ocular-phenotype-and-electroretinogram-abnormalities-in-lafora-disease-a-window-to-the-brain
#10
Ajoy Vincent, Angelo Macrì, Anupreet Tumber, Nikolas Koukas, Saija Ahonen, Pasquale Striano, Berge Minassian
No abstract text is available yet for this article.
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29907605/transthyretin-amyloid-polyneuropathies-mimicking-a-demyelinating-polyneuropathy
#11
Pierre Lozeron, Louise-Laure Mariani, Pauline Dodet, Guillemette Beaudonnet, Marie Théaudin, Clovis Adam, Bertrand Arnulf, David Adams
OBJECTIVE: To clearly define transthyretin familial amyloid polyneuropathies (TTR-FAPs) fulfilling definite clinical and electrophysiologic European Federation of Neurological Societies/Peripheral Nerve Society criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: From a cohort of 194 patients with FAP, 13 of 84 patients (15%) of French ancestry had late-onset demyelinating TTR-FAP. We compared clinical presentation and electrophysiology to a cohort with CIDP and POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndrome...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29898976/glutamatergic-synaptic-plasticity-and-dysfunction-in-alzheimer-disease-emerging-mechanisms
#12
Eduardo E Benarroch
No abstract text is available yet for this article.
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898975/critical-appraisal-of-the-recent-us-fda-approval-for-earlier-dbs-intervention
#13
REVIEW
Laura Y Cabrera, John Goudreau, Christos Sidiropoulos
In November 2015, Medtronic announced the US Food and Drug Administration (FDA) approval for the use of deep brain stimulation (DBS) therapy in people with Parkinson disease (PD) "of at least 4 years duration and with recent onset motor complications, or motor complications of longer-standing duration that are not adequately controlled with medication." The approval was based on data from the EARLYSTIM clinical trial, a randomized, prospective, multicenter, parallel-group clinical trial in Germany and France involving 251 patients with PD...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898974/practice-guideline-update-summary-efficacy-and-tolerability-of-the-new-antiepileptic-drugs-ii-treatment-resistant-epilepsy-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology-and-the-american
#14
Andres M Kanner, Eric Ashman, David Gloss, Cynthia Harden, Blaise Bourgeois, Jocelyn F Bautista, Bassel Abou-Khalil, Evren Burakgazi-Dalkilic, Esmeralda Llanas Park, John Stern, Deborah Hirtz, Mark Nespeca, Barry Gidal, Edward Faught, Jacqueline French
OBJECTIVE: To update the 2004 American Academy of Neurology guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). METHODS: 2004 criteria were used to systemically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. RESULTS: Forty-two articles were included. RECOMMENDATIONS: The following are established as effective to reduce seizure frequency (Level A): immediate-release pregabalin and perampanel for TR adult focal epilepsy (TRAFE); vigabatrin for TRAFE (not first-line treatment); rufinamide for Lennox-Gastaut syndrome (LGS) (add-on therapy)...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898973/the-changing-landscape-of-epilepsy-surgery-no-longer-the-last-resort
#15
EDITORIAL
Anne T Berg, John T Langfitt, Gregory D Cascino
No abstract text is available yet for this article.
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898972/diffuse-lewy-body-disease-manifesting-as-corticobasal-syndrome-a-rare-form-of-lewy-body-disease
#16
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898971/practice-guideline-update-summary-efficacy-and-tolerability-of-the-new-antiepileptic-drugs-i-treatment-of-new-onset-epilepsy-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology-and-the-american
#17
Andres M Kanner, Eric Ashman, David Gloss, Cynthia Harden, Blaise Bourgeois, Jocelyn F Bautista, Bassel Abou-Khalil, Evren Burakgazi-Dalkilic, Esmeralda Llanas Park, John Stern, Deborah Hirtz, Mark Nespeca, Barry Gidal, Edward Faught, Jacqueline French
OBJECTIVE: To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy with second- and third-generation antiepileptic drugs (AEDs). METHODS: The 2004 AAN criteria were used to systematically review literature (January 2003-November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. RESULTS: Several second-generation AEDs are effective for new-onset focal epilepsy...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898970/alcohol-intake-and-the-risk-of-intracerebral-hemorrhage-in-the-elderly-the-much-italy
#18
Paolo Costa, Mario Grassi, Licia Iacoviello, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Maria Luisa DeLodovici, Maria Sessa, Andrea Zini, Maurizio Paciaroni, Cristiano Azzini, Massimo Gamba, Massimo Del Sette, Antonella Toriello, Carlo Gandolfo, Domenico Marco Bonifati, Rossana Tassi, Anna Cavallini, Alberto Chiti, Rocco Salvatore Calabrò, Francesco Grillo, Paolo Bovi, Giampaolo Tomelleri, Augusto Di Castelnuovo, Marco Ritelli, Giancarlo Agnelli, Alessandro De Vito, Nicola Pugliese, Giuseppe Martini, Corrado Lodigiani, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Claudio Cornali, Giovanni de Gaetano, Marina Colombi, Alessandro Padovani, Alessandro Pezzini
OBJECTIVE: To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS: We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 years and older with a group of age- and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) between 2002 and 2014...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898969/increased-caide-dementia-risk-cognition-csf-biomarkers-and-vascular-burden-in-healthy-adults
#19
Mirian Ecay-Torres, Ainara Estanga, Mikel Tainta, Andrea Izagirre, Maite Garcia-Sebastian, Jorge Villanua, Montserrat Clerigue, Ane Iriondo, Iratxe Urreta, Arantzazu Arrospide, Carmen Díaz-Mardomingo, Miia Kivipelto, Pablo Martinez-Lage
OBJECTIVE: To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. METHOD: Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE score cutoff of 9...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29898968/association-between-diabetes-and-subsequent-parkinson-disease-a-record-linkage-cohort-study
#20
Eduardo De Pablo-Fernandez, Raph Goldacre, Julia Pakpoor, Alastair J Noyce, Thomas T Warner
OBJECTIVE: To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). METHODS: Linked English national Hospital Episode Statistics and mortality data (1999-2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis...
June 13, 2018: Neurology
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