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Marla J Hamberger, William S MacAllister, William T Seidel, Robyn M Busch, Christine M Salinas, Patricia Klaas, Mary Lou Smith
OBJECTIVE: With this prospective, observational study, we aimed to determine whether noninvasive language tasks, developed specifically for children, could reliably identify the hemisphere of seizure onset in pediatric epilepsy. METHODS: Seventy-eight children with unilateral epilepsy (44 left), aged 6-15 years (mean age = 11.8, SD = 2.6), completed the Children's Auditory Naming and Visual Naming Tests, the Boston Naming Test, and other verbal and nonverbal tasks...
December 5, 2018: Neurology
Shirin Jalini, Rajasumi Rajalingam, Rosane Nisenbaum, Angelo Dave Javier, Anna Woo, Aleksandra Pikula
OBJECTIVE: To investigate the prevalence and clinical determinants of atrial cardiopathy in patients with embolic stroke of unknown source (ESUS) and compare with other established stroke etiologies. METHODS: In a cross-sectional study of 846 consecutive patients with ischemic stroke, we compared the prevalence of atrial cardiopathy (defined by p-wave terminal force in V1 >5,000 µV·ms or severe left atrial enlargement) between ESUS patients and patients with large artery atherosclerosis (LAA) and small vessel disease (SVD) strokes...
December 5, 2018: Neurology
Bruce P Hermann, Benjamin Tolchin
No abstract text is available yet for this article.
December 5, 2018: Neurology
Abhimanyu Mahajan, Carolyn Cahill, Eugene Scharf, Sahil Gupta, Stephanie Ahrens, Elizabeth Joe, Logan Schneider
OBJECTIVE: To survey graduating US neurology residents on the topics of debt, fellowship interview process, future plans, and their readiness for practice and business management tasks. METHODS: An electronic survey was sent to all US American Academy of Neurology member adult and child neurology residents graduating in June 2017. RESULTS: The response rate was 23.4% (n = 159). Of the 143 residents who provided information about student loans, 57% reported having debt (median $180,000)...
December 5, 2018: Neurology
Dana Leifer, Tatjana Rundek
No abstract text is available yet for this article.
December 5, 2018: Neurology
Antonello Baldassarre, Nicholas V Metcalf, Gordon L Shulman, Maurizio Corbetta
OBJECTIVE: To investigate whether different language deficits are distinguished by the relative strengths of their association with the functional connectivity (FC) at rest of the language network (LN) and cingulo-opercular network (CON) after aphasic stroke. METHODS: In a group of patients with acute stroke and left-hemisphere damage, we identified 3 distinct, yet correlated, clusters of deficits including comprehension/lexical semantic, grapheme-phoneme knowledge, and verbal executive functions...
December 5, 2018: Neurology
Meher R Juttukonda, Giulia Franco, Dario J Englot, Ya-Chen Lin, Kalen J Petersen, Paula Trujillo, Peter Hedera, Bennett A Landman, Hakmook Kang, Manus J Donahue, Peter E Konrad, Benoit M Dawant, Daniel O Claassen
OBJECTIVE: To assess white matter integrity in patients with essential tremor (ET) and Parkinson disease (PD) with moderate to severe motor impairment. METHODS: Sedated participants with ET (n = 57) or PD (n = 99) underwent diffusion tensor imaging (DTI) and fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values were computed. White matter tracts were defined using 3 well-described atlases. To determine candidate white matter regions that differ between ET and PD groups, a bootstrapping analysis was applied using the least absolute shrinkage and selection operator...
November 30, 2018: Neurology
Nienke J H van Os, Anke Hensiek, Judith van Gaalen, Alexander M R Taylor, Marcel van Deuren, Corry M R Weemaes, Michèl A A P Willemsen, Bart P C van de Warrenburg
OBJECTIVE: To describe and classify the neurologic trajectories in patients with mild neurologic forms of ataxia telangiectasia (A-T) from the Dutch A-T cohort, combined with patients reported in the literature. METHODS: Clinical, genetic, and laboratory data of 14 patients with mild neurologic phenotypes of A-T from the Dutch cohort were analyzed and combined with corresponding data from the literature. A mild neurologic phenotype was defined by a later onset, nonataxia presenting or dominant feature, or slower progression compared to the classic A-T phenotype...
November 30, 2018: Neurology
Alexandre Roux, Myriam Edjlali, Sayuri Porelli, Arnault Tauziede-Espariat, Marc Zanello, Edouard Dezamis, Gilles Zah-Bi, Marc Sanson, Stéphanie Puget, Laurent Capelle, Pascale Varlet, Catherine Oppenheim, Johan Pallud
OBJECTIVE: To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma. METHODS: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié-Salpêtrière Hospital (external validation set). We included 219 patients with diffuse glioma (experimental set), 252 patients with brain metastasis (control set), and 200 patients with diffuse glioma (validation set)...
November 30, 2018: Neurology
Ryul Kim, Joongyub Lee, Han-Joon Kim, Aryun Kim, Mihee Jang, Beomseok Jeon, Un Jung Kang
OBJECTIVE: To determine whether CSF biomarkers can be used as a predictor of freezing of gait (FOG) in Parkinson disease (PD) and to investigate the predictive value of clinical, dopamine transporter (DAT) imaging, and CSF parameters both separately and in combination. METHODS: This study using the PPMI data included 393 patients with newly diagnosed PD without FOG at baseline. We evaluated CSF for β-amyloid 1-42 (Aβ42 ), α-synuclein, total tau, phosphorylated tau181 , and the calculated ratio of Aβ42 to total tau at baseline...
November 30, 2018: Neurology
Chloe E Hill, Leah J Blank, Dylan Thibault, Kathryn A Davis, Nabila Dahodwala, Brian Litt, Allison W Willis
OBJECTIVE: To characterize continuous EEG (cEEG) use patterns in the critically ill and to determine the association with hospitalization outcomes for specific diagnoses. METHODS: We performed a retrospective cross-sectional study with National Inpatient Sample data from 2004 to 2013. We sampled hospitalized adult patients who received intensive care and then compared patients who underwent cEEG to those who did not. We considered diagnostic subgroups of seizure/status epilepticus, subarachnoid or intracerebral hemorrhage, and altered consciousness...
November 30, 2018: Neurology
Zachary O Binney, Kathleen E Bachynski
No abstract text is available yet for this article.
November 28, 2018: Neurology
Philipp Albrecht, Alexander Jansen, John-Ih Lee, Marek Moll, Marius Ringelstein, Dietmar Rosenthal, Hans Bigalke, Orhan Aktas, Hans-Peter Hartung, Harald Hefter
OBJECTIVE: To investigate the prevalence of neutralizing antibodies (NABs) against botulinum neurotoxin type A (BoNT/A) during long-term BoNT/A treatment in different neurologic indications. METHODS: In this monocentric, observational cross-sectional study, 596 outpatients treated with BoNT/A for different indications were tested for BoNT/A binding antibodies by ELISA. Positive samples were investigated for NABs with the mouse hemidiaphragm test. The prevalence of NABs was analyzed for different indications: facial hemispasm, blepharospasm, cervical dystonia, other dystonia, and spasticity...
November 21, 2018: Neurology
Changzheng Yuan, Elinor Fondell, Ambika Bhushan, Alberto Ascherio, Olivia I Okereke, Francine Grodstein, Walter C Willett
OBJECTIVE: To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF). METHODS: Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future SCF. Average dietary intake was calculated from 5 repeated food frequency questionnaires collected every 4 years until 2002. SCF score was assessed twice (2008 and 2012) using a 6-item questionnaire; validity was supported by strong associations with APO ε4 genotype...
November 21, 2018: Neurology
Holland C Detke, Peter J Goadsby, Shufang Wang, Deborah I Friedman, Katherine J Selzler, Sheena K Aurora
OBJECTIVE: To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide, in the preventive treatment of chronic migraine. METHODS: A phase 3, randomized, double-blind, placebo-controlled study of LY2951742 in patients with chronic migraine (Evaluation of Galcanezumab in the Prevention of Chronic Migraine [REGAIN]) was a phase 3 study with a 3-month double-blind, placebo-controlled treatment phase and a 9-month open-label extension...
November 16, 2018: Neurology
Bernice Kuca, Stephen D Silberstein, Linda Wietecha, Paul H Berg, Gregory Dozier, Richard B Lipton
OBJECTIVE: To assess the efficacy and safety of lasmiditan in the acute treatment of migraine. METHODS: Adult patients with migraine were randomized (1:1:1) to a double-blind dose of oral lasmiditan 200 mg, lasmiditan 100 mg, or placebo and were asked to treat their next migraine attack within 4 hours of onset. Over 48 hours after dosing, patients used an electronic diary to record headache pain and the presence of nausea, phonophobia, and photophobia, one of which was designated their most bothersome symptom (MBS)...
November 16, 2018: Neurology
W Taylor Kimberly, Matthew B Bevers, Rüdiger von Kummer, Andrew M Demchuk, Javier M Romero, Jordan J Elm, Holly E Hinson, Bradley J Molyneaux, J Marc Simard, Kevin N Sheth
OBJECTIVE: In this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on adjudicated, edema-related endpoints. METHODS: Blinded adjudicators assigned designations for hemorrhagic transformation, neurologic deterioration, malignant edema, and edema-related death to patients from the GAMES-RP phase II randomized controlled trial of IV glyburide for large hemispheric infarct. Rates of these endpoints were compared between treatment arms in the per-protocol sample...
November 16, 2018: Neurology
Sebastian Fridman, Luciano A Sposato
No abstract text is available yet for this article.
November 14, 2018: Neurology
Ruth Ann Marrie, Helmut Butzkueven, Alberto Ascherio
No abstract text is available yet for this article.
November 14, 2018: Neurology
Souvik Sen, X Michelle Androulakis, Viktoriya Duda, Alvaro Alonso, Lin Yee Chen, Elsayed Z Soliman, Jared Magnani, Tushar Trivedi, Anwar T Merchant, Rebecca F Gottesman, Wayne D Rosamond
OBJECTIVE: Migraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study. METHODS: In the Atherosclerosis Risk in Communities study, a longitudinal, community-based cohort study, participants were interviewed for migraine history in 1993-1995 and were followed for incident AF through 2013. AF was adjudicated using ECGs, discharge codes, and death certificates...
November 14, 2018: Neurology
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