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Neurology

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https://www.readbyqxmd.com/read/29444975/approaching-adaptive-control-in-neurostimulation-for-parkinson-disease-autopilot-on
#1
EDITORIAL
Daniel Weiss, João Massano
No abstract text is available yet for this article.
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444974/a-35-year-analysis-of-sex-differences-in-neurology-authorship
#2
Jina Pakpoor, Li Liu, David Yousem
Career progression in academic medicine is partly influenced by publication productivity. There has been a significant increase in female authorship over a 35-year time period at both the first and senior authorship positions in 3 high impact factor neurology journals in the United States. While these trends are encouraging, a sex gap remains. Institutions/departments may wish to consider further strategies for trainees and faculty that can help to maintain momentum and narrow the gap further.
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444973/eight-hours-adaptive-deep-brain-stimulation-in-patients-with-parkinson-disease
#3
Mattia Arlotti, Sara Marceglia, Guglielmo Foffani, Jens Volkmann, Andres M Lozano, Elena Moro, Filippo Cogiamanian, Marco Prenassi, Tommaso Bocci, Francesca Cortese, Paolo Rampini, Sergio Barbieri, Alberto Priori
OBJECTIVES: To assess the feasibility and clinical efficacy of local field potentials (LFPs)-based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease (PD) during daily activities in an open-label, nonblinded study. METHODS: We monitored neurophysiologic and clinical fluctuations during 2 perioperative experimental sessions lasting for up to 8 hours. On the first day, the patient took his/her daily medication, while on the second, he/she additionally underwent subthalamic nucleus aDBS driven by LFPs beta band power...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444972/usefulness-of-adamts13-to-predict-response-to-recanalization-therapies-in-acute-ischemic-stroke
#4
Alejandro Bustamante, MingMing Ning, Teresa García-Berrocoso, Anna Penalba, Cristina Boada, Alba Simats, Jorge Pagola, Marc Ribó, Carlos Molina, Eng Lo, Joan Montaner
OBJECTIVE: We aimed to analyze ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in relation to arterial recanalization in patients treated with IV tissue plasminogen activator (tPA) and in relation to futile recanalization in patients treated with mechanical thrombectomy. METHODS: Acute ischemic stroke patients (n = 108) with documented arterial occlusions treated with IV-tPA were selected. ADAMTS13 activity was measured by ELISA in samples collected before treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444971/anosognosia-predicts-default-mode-network-hypometabolism-and-clinical-progression-to-dementia
#5
Joseph Therriault, Kok Pin Ng, Tharick A Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Hanne Struyfs, Monica Shin, Andrea L Benedet, Ishan C Walpola, Vasavan Nair, Serge Gauthier, Pedro Rosa-Neto
OBJECTIVE: To identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment. METHODS: We stratified 468 patients with amnestic mild cognitive impairment into intact and impaired awareness groups, determined by the discrepancy between the patient and the informant score on the Everyday Cognition questionnaire. Voxel-based linear regression models evaluated the associations between self-awareness status and baseline β-amyloid load, measured by [ 18 F]florbetapir, and the relationships between awareness status and regional brain glucose metabolism measured by [ 18 F]fluorodeoxyglucose at baseline and at 24-month follow-up...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444970/cytoplasmic-rna-granules-ribostasis-and-neurodegeneration
#6
Eduardo E Benarroch
No abstract text is available yet for this article.
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444969/atrial-fibrillation-detected-after-stroke-is-related-to-a-low-risk-of-ischemic-stroke-recurrence
#7
Luciano A Sposato, Joshua O Cerasuolo, Lauren E Cipriano, Jiming Fang, Sebastian Fridman, Maryse Paquet, Gustavo Saposnik
OBJECTIVE: To compare the risk of 1-year ischemic stroke recurrence between atrial fibrillation (AF) diagnosed after stroke (AFDAS) and sinus rhythm (SR) and investigate whether underlying heart disease is as frequent in AFDAS as it is in AF known before stroke (KAF). METHODS: In this retrospective cohort study, we included all ischemic stroke patients admitted to institutions participating in the Ontario Stroke Registry from July 1, 2003, to March 31, 2013. Based on heart rhythm assessed during admission, we classified patients as AFDAS, KAF, or SR...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444968/behavioral-interventions-as-a-treatment-for-epilepsy-a-multicenter-randomized-controlled-trial
#8
Sheryl R Haut, Richard B Lipton, Susannah Cornes, Alok K Dwivedi, Rachel Wasson, Sian Cotton, Jeffrey R Strawn, Michael Privitera
OBJECTIVE: To evaluate the effect of a stress-reduction intervention in participants with medication-resistant epilepsy. METHODS: Adults with medication-resistant focal epilepsy (n = 66) were recruited from 3 centers and randomized to 1 of 2 interventions: (1) progressive muscle relaxation (PMR) with diaphragmatic breathing, or (2) control focused-attention activity with extremity movements. Following an 8-week baseline period, participants began 12 weeks of double-blind treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444967/insights-into-atrial-fibrillation-newly-diagnosed-after-stroke-can-the-brain-rule-the-heart
#9
EDITORIAL
David J Seiffge, Minoru Tagawa
No abstract text is available yet for this article.
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444966/cerebral-microbleeds-and-csf-alzheimer-biomarkers-in-primary-progressive-aphasias
#10
Aline Mendes, Anne Bertrand, Foudil Lamari, Olivier Colliot, Alexandre Routier, Olivier Godefroy, Frédérique Etcharry-Bouyx, Olivier Moreaud, Florence Pasquier, Philippe Couratier, Karim Bennys, Martine Vercelletto, Olivier Martinaud, Bernard Laurent, Jérémie Pariente, Michèle Puel, Stéphane Epelbaum, Serge Belliard, Takoua Kaaouana, Ludovic Fillon, Marie Chupin, Bruno Dubois, Marc Teichmann
OBJECTIVE: To reveal the prevalence and localization of cerebral microbleeds (CMBs) in the 3 main variants of primary progressive aphasia (PPA) (logopenic, semantic, and nonfluent/agrammatic), to identify the relationship with underlying Alzheimer pathology, and to explore whether CMBs contribute to language breakdown. METHODS: We used a cross-sectional design in a multicenter cohort of 82 patients with PPA and 19 similarly aged healthy controls. MRI allowed for rating CMBs (2-dimensional gradient recalled echo T2*, susceptibility weighted imaging sequences) and white matter hyperintensities...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444965/personalizing-acute-therapies-for-ischemic-stroke-thrombolysis-or-thrombectomy
#11
EDITORIAL
Jin-Moo Lee, Tomasz Dziedzic
No abstract text is available yet for this article.
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29444964/electrical-stimulation-of-the-dorsolateral-prefrontal-cortex-impairs-semantic-cognition
#12
Guillaume Herbet, Sylvie Moritz-Gasser, Hugues Duffau
OBJECTIVE: To identify the prefrontal cortical structures causally involved in verbal and nonverbal semantic cognition in both cerebral hemispheres. METHODS: We retrospectively screened the intraoperative brain mapping data of 584 patients who underwent neurosurgery for neoplastic tumor under local anesthesia with direct cortical electrostimulation. Patients were included if they were right-handed, recently diagnosed with a diffuse low-grade glioma, and had a positive language mapping for verbal (naming task) and nonverbal (visual semantic association task) semantic cognition in the prefrontal cortex (n = 49)...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29440566/comprehensive-systematic-review-summary-treatment-of-cerebellar-motor-dysfunction-and-ataxia-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#13
Theresa A Zesiewicz, George Wilmot, Sheng-Han Kuo, Susan Perlman, Patricia E Greenstein, Sarah H Ying, Tetsuo Ashizawa, S H Subramony, Jeremy D Schmahmann, K P Figueroa, Hidehiro Mizusawa, Ludger Schöls, Jessica D Shaw, Richard M Dubinsky, Melissa J Armstrong, Gary S Gronseth, Kelly L Sullivan
OBJECTIVE: To systematically review evidence regarding ataxia treatment. METHODS: A comprehensive systematic review was performed according to American Academy of Neurology methodology. CONCLUSIONS: For patients with episodic ataxia type 2, 4-aminopyridine 15 mg/d probably reduces ataxia attack frequency over 3 months (1 Class I study). For patients with ataxia of mixed etiology, riluzole probably improves ataxia signs at 8 weeks (1 Class I study)...
February 9, 2018: Neurology
https://www.readbyqxmd.com/read/29440565/flortaucipir-imaging-of-mapt-mutations-emphasize-challenges-for-tau-targeted-trials
#14
EDITORIAL
Corey T McMillan, Edward D Huey
No abstract text is available yet for this article.
February 9, 2018: Neurology
https://www.readbyqxmd.com/read/29440564/fulminant-encephalopathy-with-unusual-brain-imaging-in-disulfiram-toxicity
#15
Dhanashree Peddawad, Shashank Nagendra, Rudrarpan Chatterjee, Hina Faldu, Akash Chheda
No abstract text is available yet for this article.
February 9, 2018: Neurology
https://www.readbyqxmd.com/read/29440563/in-vivo-18-f-av-1451-tau-pet-signal-in-mapt-mutation-carriers-varies-by-expected-tau-isoforms
#16
David T Jones, David S Knopman, Jonathan Graff-Radford, Jeremy A Syrjanen, Matthew L Senjem, Christopher G Schwarz, Christina Dheel, Zbigniew Wszolek, Rosa Rademakers, Kejal Kantarci, Ronald C Petersen, Clifford R Jack, Val J Lowe, Bradley F Boeve
OBJECTIVE: To evaluate 18 F-AV-1451 tau-PET binding among microtubule-associated protein tau ( MAPT ) mutation carriers. METHODS: Using a case-control study, we quantitatively and qualitatively compared tau-PET scans in 10 symptomatic and 3 asymptomatic MAPT mutation carriers (n = 13, age range 42-67 years) with clinically normal (CN) participants (n = 241, age range 42-67 years) and an Alzheimer disease (AD) dementia cohort (n = 30, age range 52-67 years). Eight participants had MAPT mutations that involved exon 10 (N279K n = 5, S305N n = 2, P301L n = 1) and tend to form 4R tau pathology, and 5 had mutations outside exon 10 (V337M n = 2, R406W n = 3) and tend to form mixed 3R/4R tau pathology...
February 9, 2018: Neurology
https://www.readbyqxmd.com/read/29438046/pregnancy-decision-making-in-women-with-multiple-sclerosis-treated-with-natalizumab-i-fetal-risks
#17
Emilio Portaccio, Pietro Annovazzi, Angelo Ghezzi, Mauro Zaffaroni, Lucia Moiola, Vittorio Martinelli, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Rinaldi, Paolo Gallo, Carla Tortorella, Damiano Paolicelli, Carlo Pozzilli, Laura De Giglio, Paola Cavalla, Eleonora Cocco, Maria Giovanna Marrosu, Francesco Patti, Claudio Solaro, Paolo Bellantonio, Antonio Uccelli, Alice Laroni, Luisa Pastò, Marta Giannini, Maria Trojano, Giancarlo Comi, Maria Pia Amato
OBJECTIVE: To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), with a specific focus on spontaneous abortion (SA) and congenital anomalies (CA). METHODS: Data of all pregnancies occurring between 2009 and 2015 in patients with MS treated with natalizumab and referring to 19 participating sites were collected and compared with those of pregnancies in untreated patients and patients treated with injectable immunomodulatory agents...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29438045/double-target-dbs-for-essential-tremor-8-contact-lead-for-czi-and-vim-aligned-in-the-same-trajectory
#18
Maria Gabriela Dos Santos Ghilardi, Melisa Ibarra, Eduardo J L Alho, Paul Rodrigo Reis, William Omar Lopez Contreras, Clement Hamani, Erich Talamoni Fonoff
No abstract text is available yet for this article.
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29438044/impairment-of-cross-modality-of-vision-and-olfaction-in-parkinson-disease
#19
Motoyasu Honma, Yuri Masaoka, Takeshi Kuroda, Akinori Futamura, Azusa Shiromaru, Masahiko Izumizaki, Mitsuru Kawamura
OBJECTIVE: To determine whether Parkinson disease (PD) affects cross-modal function of vision and olfaction because it is known that PD impairs various cognitive functions, including olfaction. METHODS: We conducted behavioral experiments to identify the influence of PD on cross-modal function by contrasting patient performance with age-matched normal controls (NCs). We showed visual effects on the strength and preference of odor by manipulating semantic connections between picture/odorant pairs...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29438043/selective-cognitive-impairment-and-hyposmia-in-p-a53t-snca-pd-vs-typical-pd
#20
Christos Koros, Maria Stamelou, Athina Simitsi, Ion Beratis, Dimitra Papadimitriou, Nikolaos Papagiannakis, Stella Fragkiadaki, Dionysia Kontaxopoulou, Sokratis G Papageorgiou, Leonidas Stefanis
OBJECTIVE: To evaluate nonmotor symptoms in early SNCA /p.A53T Parkinson disease (PD) (A53T PD) compared to typical PD (tPD). METHODS: The presence of hyposmia, neuropsychiatric, dysautonomic, and sleep disturbances was assessed by standardized questionnaires and validated scales in 18 patients with A53T PD and 18 patients with tPD, matched for age, sex, and disease duration. All patients were enrolled into the Parkinson's Progression Markers Initiative study. RESULTS: The levodopa equivalent daily dose was higher in the A53T PD ( p = 0...
February 7, 2018: Neurology
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