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Nephrology, Dialysis, Transplantation

Stanley M H Yeung, Liffert Vogt, Joris I Rotmans, Ewout J Hoorn, Martin H de Borst
No abstract text is available yet for this article.
November 12, 2018: Nephrology, Dialysis, Transplantation
Ron T Gansevoort
After decades of Babylonian confusion, we finally have a clear, uniform and widely accepted definition of chronic kidney disease (CKD). Based on evidence, and in accordance with other diseases, this definition is independent of age. This has made it possible to study the relevance and prevalence of CKD. We now know that CKD is associated with a myriad of health problems. We have also learned that studying the prevalence of CKD is difficult from a methodological perspective. But whatever the exact prevalence may be, we can safely conclude that CKD is common and that the crude prevalence of treated end-stage kidney disease is increasing, as is the importance of morbidity and mortality caused by CKD...
November 12, 2018: Nephrology, Dialysis, Transplantation
Pierre Delanaye
The prevalence of chronic kidney disease (CKD) clearly depends on its definition, and the definition used most often is the one proposed by the Kidney Disease: Improving Global Outcomes guidelines in 2012: 'CKD is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health.' Abnormality of kidney function is a glomerular filtration rate (GFR) <60 mL/min/1.73 m2, and the most frequently used marker of kidney damage is the presence of albuminuria [albumin excretion rate >30 mg/24 h or albumin/creatinine ratio (ACR) >30 mg/g (or 3 mg/mmol)]...
November 12, 2018: Nephrology, Dialysis, Transplantation
Kei Sugiyama, Tsutomu Inoue, Eito Kozawa, Masahiro Ishikawa, Akira Shimada, Naoki Kobayashi, Junji Tanaka, Hirokazu Okada
Background: Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level-dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function. Methods: The study was conducted under a single-center, longitudinal, retrospective observational design...
November 12, 2018: Nephrology, Dialysis, Transplantation
Rosanna Coppo, Graziella D'Arrigo, Giovanni Tripepi, Maria Luisa Russo, Ian S D Roberts, Shubha Bellur, Daniel Cattran, Terence H Cook, John Feehally, Vladimir Tesar, Dita Maixnerova, Licia Peruzzi, Alessandro Amore, Sigrid Lundberg, Anna Maria Di Palma, Loreto Gesualdo, Francesco Emma, Cristiana Rollino, Manuel Praga, Luigi Biancone, Antonello Pani, Sandro Feriozzi, Rosaria Polci, Jonathan Barratt, Lucia Del Vecchio, Francesco Locatelli, Alessandro Pierucci, Yasar Caliskan, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Elisabetta Moggia, José C Ballarin, Jack F M Wetzels, Dimitris Goumenos, Marios Papasotiriou, Kresimir Galesic, Luka Toric, Aikaterini Papagianni, Maria Stangou, Luisa Benozzi, Stefano Cusinato, Ulla Berg, Rezan Topaloglu, Milena Maggio, Mai Ots-Rosenberg, Marco D'Amico, Colin Geddes, Olga Balafa, Marco Quaglia, Raffaella Cravero, Calogero Lino Cirami, Bengt Fellstrom, Jürgen Floege, Jesus Egido, Francesca Mallamaci, Carmine Zoccali
Background: It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up. Methods: In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4...
November 9, 2018: Nephrology, Dialysis, Transplantation
Joanna Stachowska-Pietka, Jan Poleszczuk, Michael F Flessner, Bengt Lindholm, Jacek Waniewski
Background: Ultrafiltration failure (UFF) in peritoneal dialysis (PD) patients is due to altered peritoneal transport properties leading to reduced capacity to remove excess water. Here, with the aim to establish the role of local alterations of the two major transport barriers, peritoneal tissue and capillary wall, we investigate changes in overall peritoneal transport characteristics in UFF patients in relation to corresponding local alterations of peritoneal tissue and capillary wall transport properties...
November 6, 2018: Nephrology, Dialysis, Transplantation
Sara Nuovo, Laura Fuiano, Alessia Micalizzi, Roberta Battini, Enrico Bertini, Renato Borgatti, Gianluca Caridi, Stefano D'Arrigo, Elisa Fazzi, Rita Fischetto, Gian Marco Ghiggeri, Lucio Giordano, Vincenzo Leuzzi, Romina Romaniello, Sabrina Signorini, Gilda Stringini, Ginevra Zanni, Marta Romani, Enza Maria Valente, Francesco Emma
Background: Joubert syndrome (JS) is an inherited ciliopathy characterized by a complex midbrain-hindbrain malformation and multiorgan involvement. Renal disease, mainly juvenile nephronophthisis (NPH), was reported in 25-30% patients although only ∼18% had a confirmed diagnosis of chronic kidney disease (CKD). NPH often remains asymptomatic for many years, resulting in delayed diagnosis. The aim of the study was to identify a biomarker able to quantify the risk of progressive CKD in young children with JS...
November 6, 2018: Nephrology, Dialysis, Transplantation
Noémie Simon-Tillaux, Edouard Lecarpentier, Vassilis Tsatsaris, Alexandre Hertig
Preeclampsia is a hypertensive disorder of pregnancy and the clinical manifestation of severe endothelial dysfunction associated with maternal and foetal morbidity and mortality. The primum movens of the disease is the defect of invasion of the uterine arteries by foetal syncytiotrophoblasts, which causes a maladaptive placental response to chronic hypoxia and the secretion of the soluble form of type 1 vascular growth endothelial factor receptor, also called soluble fms-like tyrosine kinase 1 (sFlt-1), the major player in the pathophysiology of the disease...
November 6, 2018: Nephrology, Dialysis, Transplantation
Harini A Chakkera, Aleksandar Denic, Walter K Kremers, Mark D Stegall, Joseph J Larson, Harish Ravipati, Sandra J Taler, John C Lieske, Lilach O Lerman, Joshua J Augustine, Andrew D Rule
Background: High glomerular filtration rate (GFR) is often used as a surrogate for single-nephron hyperfiltration. Our objective was to determine the definition for high GFR that best reflects clinical and structural characteristics of hyperfiltration. Methods: We studied living kidney donors at the Mayo Clinic and Cleveland Clinic. Potential donors underwent evaluations that included measured GFR (mGFR) by iothalamate clearance and estimated GFR (eGFR) by the serum creatinine-based Chronic Kidney Disease-Epidemiology collaboration (CKD-EPI) equation...
November 6, 2018: Nephrology, Dialysis, Transplantation
Pablo Antonio Ureña Torres, Martine Cohen-Solal
No abstract text is available yet for this article.
November 6, 2018: Nephrology, Dialysis, Transplantation
Rebecca J Schmidt, Daniel L Landry, Lewis Cohen, Alvin H Moss, Cheryl Dalton, Brian H Nathanson, Michael J Germain
Background: Guiding patients with advanced chronic kidney disease (CKD) through advance care planning about future treatment obliges an assessment of prognosis. A patient-specific integrated model to predict mortality could inform shared decision-making for patients with CKD. Methods: Patients with Stages 4 and 5 CKD from Massachusetts (749) and West Virginia (437) were prospectively evaluated for clinical parameters, functional status [Karnofsky Performance Score (KPS)] and their provider's response to the Surprise Question (SQ)...
November 5, 2018: Nephrology, Dialysis, Transplantation
Nupur N Uppal, Divya Monga, Melchiore A Vernace, Khurram Mehtabdin, Hitesh H Shah, Vanesa Bijol, Kenar D Jhaveri
Waldenström macroglobulinemia (WM) is a rare B-cell lymphoma characterized by lymphoplasmacytic cell infiltration in the bone marrow and other organs and the presence of a monoclonal immunoglobulin M protein in the serum. Although uncommon, several kidney diseases have been associated with WM. In addition to kidney diseases related to lymphoplasmacytic lymphoma infiltration, a variety of glomerular and tubular lesions have been described in patients with WM. Immunoglobulin light chain (AL) amyloidosis and cryoglobulinemic glomerulonephritis are the two predominant glomerular pathologies seen in WM...
October 31, 2018: Nephrology, Dialysis, Transplantation
Sarah M Moran, Paul A Monach, Lina Zgaga, David Cuthbertson, Simon Carette, Nader A Khalidi, Curry L Koening, Carol A Langford, Carol A McAlear, Larry Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine Sreih, Jason Wyse, Steven R Ytterberg, Peter A Merkel, Mark A Little
Background: Prior work has shown that urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis using samples that included new diagnoses with highly active renal disease. This study focused on the use of usCD163 in the detection of the more clinically relevant state of mild renal flare and compared results of usCD163 testing directly to testing of urinary monocyte chemoattractant protein-1 (uMCP-1). Methods: Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV, n = 88) were identified within a serially sampled, longitudinal and multicentre cohort...
October 31, 2018: Nephrology, Dialysis, Transplantation
Geoffrey A Block, Pablo E Pergola, Steven Fishbane, Julian G Martins, Robin D LeWinter, Katrin Uhlig, John F Neylan, Glenn M Chertow
Background: Among patients with nondialysis-dependent chronic kidney disease (NDD-CKD) and iron-deficiency anemia (IDA), ferric citrate increases hemoglobin and iron parameters and reduces serum phosphate and fibroblast growth factor 23 (FGF23), a key phosphate-regulating hormone. We conducted post hoc analyses of a phase 3 trial to explore associations between iron replacement, serum phosphate changes and FGF23 regulation. Methods: We employed multivariable regression and longitudinal mixed-effects models to identify and confirm, respectively, whether baseline demographic and laboratory variables were associated with ferric citrate-induced changes in serum phosphate or FGF23 concentrations...
October 30, 2018: Nephrology, Dialysis, Transplantation
Jesper Kers, Hessel Peters-Sengers, Martin B A Heemskerk, Stefan P Berger, Michiel G H Betjes, Arjan D van Zuilen, Luuk B Hilbrands, Johan W de Fijter, Azam S Nurmohamed, Maarten H Christiaans, Jaap J Homan van der Heide, Thomas P A Debray, Fréderike J Bemelman
No abstract text is available yet for this article.
October 29, 2018: Nephrology, Dialysis, Transplantation
Mårten Segelmark, Thomas Hellmark
Most patients with anti-glomerular basement membrane (anti-GBM) disease present with rapidly progressive glomerulonephritis with or without pulmonary haemorrhage; however, there are several variants and vigilance is necessary to make a correct diagnosis. Such variants include overlap with anti-neutrophil cytoplasm antibodies-associated vasculitis and membranous nephropathy as well as anti-GBM occurring de novo after renal transplantation. Moreover, patients can present with isolated pulmonary haemorrhage as well as with negative tests for circulating anti-GBM...
October 29, 2018: Nephrology, Dialysis, Transplantation
Laura A Michielsen, Bram W Wisse, Elena G Kamburova, Marianne C Verhaar, Irma Joosten, Wil A Allebes, Arnold van der Meer, Luuk B Hilbrands, Marije C Baas, Eric Spierings, Cornelis E Hack, Franka E van Reekum, Michiel L Bots, Adriaan C A D Drop, Loes Plaisier, Marc A J Seelen, Jan-Stephan F Sanders, Bouke G Hepkema, Annechien J Lambeck, Laura B Bungener, Caroline Roozendaal, Marcel G J Tilanus, Christien E Voorter, Lotte Wieten, Elizabeth M van Duijnhoven, Mariëlle Gelens, Maarten H L Christiaans, Frans J van Ittersum, Shaikh A Nurmohamed, Neubury M Lardy, Wendy Swelsen, Karlijn A van der Pant, Neelke C van der Weerd, Ineke J M Ten Berge, Frederike J Bemelman, Andries Hoitsma, Paul J M van der Boog, Johan W de Fijter, Michiel G H Betjes, Sebastiaan Heidt, Dave L Roelen, Frans H Claas, Henderikus G Otten, Arjan D van Zuilen
Background: Pre-transplant donor-specific anti-human leucocyte antigen (HLA) antibodies (DSAs) are associated with impaired kidney graft survival while the clinical relevance of non-donor-specific anti-HLA antibodies (nDSAs) is more controversial. The aim of the present paired kidney graft study was to compare the clinical relevance of DSAs and nDSAs. Methods: To eliminate donor and era-dependent factors, a post hoc paired kidney graft analysis was performed as part of a Dutch multicentre study evaluating all transplantations between 1995 and 2005 with available pre-transplant serum samples...
October 25, 2018: Nephrology, Dialysis, Transplantation
Myriam Benomar, Clement Vachey, Thierry Lobbedez, Julie Henriques, Didier Ducloux, Dewi Vernerey, Cécile Courivaud
Background: Failed kidney transplant is becoming a frequent cause of dialysis initiation. Although studies have shown no difference between peritoneal dialysis (PD) and haemodialysis (HD) in terms of patients and technique survival, PD remains quite rarely used in this condition. Studies in larger multicentre matched cohorts are missing. Methods: We conducted a retrospective study about 328 patients registered in the French Language Peritoneal Dialysis Registry (RDPLF) who started PD after kidney transplant failure (Tx group) between January 2002 and December 2012 who were compared with 656 matched never-transplanted patients having started PD during the same period (control group)...
October 24, 2018: Nephrology, Dialysis, Transplantation
Liang Wu, Xiao-Qian Li, Dong-Yuan Chang, Huifen Zhang, Jun-Juan Li, Shou-Ling Wu, Lu-Xia Zhang, Min Chen, Ming-Hui Zhao
Background: In diabetic kidney disease (DKD), it is important to find biomarkers for predicting initiation and progression of the disease. Besides glomerular damage, kidney tubular injury and inflammation are also involved in the development of DKD. The current study investigated the associations of urinary epidermal growth factor (uEGF), monocyte chemotactic protein-1 (MCP-1) and the uEGF:MCP-1 ratio with kidney involvement in patients at early and advanced stages of DKD. Methods: The concentration of uEGF and uMCP-1 was measured in two Chinese population-based studies...
October 23, 2018: Nephrology, Dialysis, Transplantation
Raja Mohammed Kaja Kamal, Ken Farrington, Amanda D Busby, David Wellsted, Humza Chandna, Laura J Mawer, Sivakumar Sridharan, Enric Vilar
Background: Initiating twice-weekly haemodialysis (2×HD) in patients who retain significant residual kidney function (RKF) may have benefits. We aimed to determine differences between patients initiated on twice- and thrice-weekly regimes, with respect to loss of kidney function, survival and other safety parameters. Methods: We conducted a single-centre retrospective study of patients initiating dialysis with a residual urea clearance (KRU) of ≥3 mL/min, over a 20-year period...
October 23, 2018: Nephrology, Dialysis, Transplantation
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