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Nephrology, Dialysis, Transplantation

Eric Rondeau, Stanislas Faguer, Thomas Robert
No abstract text is available yet for this article.
January 9, 2019: Nephrology, Dialysis, Transplantation
José Alberto Navarro-García, Carmen Delgado, María Fernández-Velasco, Almudena Val-Blasco, Elena Rodríguez-Sánchez, Jennifer Aceves-Ripoll, Nieves Gómez-Hurtado, Teresa Bada-Bosch, Evangelina Mérida-Herrero, Eduardo Hernández, Manuel Praga, Rafael Salguero, Jorge Solís, Fernando Arribas, Juan F Delgado, Héctor Bueno, Makoto Kuro-O, Luis Miguel Ruilope, Gema Ruiz-Hurtado
Background: Cardiac dysfunction and arrhythmia are common and onerous cardiovascular events in end-stage renal disease (ESRD) patients, especially those on dialysis. Fibroblast growth factor (FGF)-23 is a phosphate-regulating hormone whose levels dramatically increase as renal function declines. Beyond its role in phosphorus homeostasis, FGF-23 may elicit a direct effect on the heart. Whether FGF-23 modulates ventricular cardiac rhythm is unknown, prompting us to study its role on excitation-contraction (EC) coupling...
January 9, 2019: Nephrology, Dialysis, Transplantation
Christina-Alexandra Schulz, Gunnar Engström, Jan Nilsson, Peter Almgren, Marinka Petkovic, Anders Christensson, Peter M Nilsson, Olle Melander, Marju Orho-Melander
Background: The kidney injury molecule-1 (KIM-1) has previously been associated with kidney function in rodents and humans. Yet its role as a predictive marker for future decline in kidney function has remained less clear. Methods: At baseline (1991-1994), fasting plasma KIM-1 (p-KIM-1) was measured in 4739 participants of the population-based Malmö Diet and Cancer Study. Creatinine and cystatin C were used to calculate estimated glomerular filtration rate (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Collaboration 2012 creatinine-cystatin C equation at baseline and follow-up examination (2007-2012)...
January 9, 2019: Nephrology, Dialysis, Transplantation
Raymond Vanholder, Vianda S Stel, Kitty J Jager, Norbert Lameire, Fiona Loud, Rainer Oberbauer, Rianne W de Jong, Carmine Zoccali
Kidney transplantation offers better outcomes and quality of life at lower societal costs compared with other options of renal replacement therapy. In this review of the European Kidney Health Alliance, the current status of kidney transplantation throughout Europe and suggestions for improvement of transplantation rates are reported. Although the European Union (EU) has made considerable efforts in the previous decade to stimulate transplantation activity, the discrepancies among European countries suggest that there is still room for improvement...
January 9, 2019: Nephrology, Dialysis, Transplantation
Umberto Maggiore, Daniel Abramowicz, Klemens Budde, Marta Crespo, Christophe Mariat, Rainer Oberbauer, Julio Pascual, Licia Peruzzi, Soren Schwartz Sorensen, Ondrej Viklicky, Bruno Watschinger, Gabriel C Oniscu, Uwe Heemann, Luuk B Hilbrands
Background: Existing guidelines on the evaluation and preparation of recipients for kidney transplantation target the entire spectrum of patients with end-stage renal disease. Within the ERA-EDTA Developing Education Science and Care for Renal Transplantation in European States (DESCARTES) Working Group, it was proposed that in a subset of relatively young patients (<40 years) without significant comorbidities (such as diabetes or cardiovascular disease), the work-up for transplantation could be restricted to a small set of tests...
January 9, 2019: Nephrology, Dialysis, Transplantation
John A Kellum, Norbert Lameire
No abstract text is available yet for this article.
January 8, 2019: Nephrology, Dialysis, Transplantation
Takamasa Iwakura, Zhibo Zhao, Julian A Marschner, Satish Kumar Devarapu, Hideo Yasuda, Hans Joachim Anders
Background: Cisplatin is an effective chemotherapeutic agent. However, acute kidney injury (AKI) and subsequent kidney function decline limits its use. Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to attenuate kidney injury in some in vivo models, but the mechanisms-of-action in tubule recovery upon AKI remain speculative. We hypothesized that DPP-4 inhibitor teneligliptin (TG) can facilitate kidney recovery after cisplatin-induced AKI. Methods: In in vivo experiment, AKI was induced in rats by injecting 5 mg/kg of cisplatin intravenously...
January 8, 2019: Nephrology, Dialysis, Transplantation
Dimitrie Siriopol, Mihaela Siriopol, Stefano Stuard, Luminita Voroneanu, Peter Wabel, Ulrich Moissl, Daniela Voiculescu, Adrian Covic
Background: Both baseline fluid overload (FO) and fluid depletion are associated with increased mortality risk and cardiovascular complications in haemodialysis patients. Fluid status may vary substantially over time, and this variability could also be associated with poor outcomes. Methods: In our retrospective cohort study, including 4114 haemodialysis patients from 34 Romanian dialysis units, we investigated both all-cause and cardiovascular mortality risk according to baseline pre- and post-dialysis volume status, changes in pre- and post-dialysis fluid status during follow-up (time-varying survival analysis), pre-post changes in volume status during dialysis and pre-dialysis fluid status variability during the first 6 months of evaluation...
January 8, 2019: Nephrology, Dialysis, Transplantation
Hyoungnae Kim, Jimin Park, Ki Heon Nam, Jong Hyun Jhee, Hae-Ryong Yun, Jung Tak Park, Seung Hyeok Han, Wookyung Chung, Kook-Hwan Oh, Sue Kyung Park, Soo Wan Kim, Shin-Wook Kang, Kyu Hun Choi, Curie Ahn, Tae-Hyun Yoo
Background: Recent experimental study reported that proteinuria increases serum phosphate by decreasing biologic activity of fibroblast growth factor 23 (FGF-23). We examined this relationship in a large chronic kidney disease (CKD) cohort and evaluated the combined effect of proteinuria, FGF-23 activity and serum phosphate on CKD progression. Methods: The activity of FGF-23, measured by the fractional excretion of phosphate (FEP)/FGF-23 ratio, was compared according to the degree of proteinuria in 1909 patients with CKD...
January 4, 2019: Nephrology, Dialysis, Transplantation
Pablo Otero Alonso, Miguel Pérez Fontán, Antía López Iglesias, Teresa García Falcón, Ana Rodríguez-Carmona
Background: Preservation of residual kidney function (RKF) is a relevant objective in peritoneal dialysis (PD) patients. The influence of dietary protein intake (PI) on this variable has not been adequately investigated. Methods: Following an observational design, we studied 336 patients incident on PD, with a minimum follow-up of 6 months. The main study variable was the mean PI [normalized rate of protein nitrogen appearance (nPNA)] during the first 4 months on PD...
January 4, 2019: Nephrology, Dialysis, Transplantation
Lena Berchtold, Iris Friedli, Lindsey A Crowe, Chantal Martinez, Solange Moll, Karine Hadaya, Thomas de Perrot, Christophe Combescure, Pierre-Yves Martin, Jean-Paul Vallée, Sophie de Seigneux
Background: Kidney cortical interstitial fibrosis (IF) is highly predictive of renal prognosis and is currently assessed by the evaluation of a biopsy. Diffusion magnetic resonance imaging (MRI) is a promising tool to evaluate kidney fibrosis via the apparent diffusion coefficient (ADC), but suffers from inter-individual variability. We recently applied a novel MRI protocol to allow calculation of the corticomedullary ADC difference (ΔADC). We here present the validation of ΔADC for fibrosis assessment in a cohort of 164 patients undergoing biopsy and compare it with estimated glomerular filtration rate (eGFR) and other plasmatic parameters for the detection of fibrosis...
January 4, 2019: Nephrology, Dialysis, Transplantation
Gurbey Ocak, Chava Ramspek, Maarten B Rookmaaker, Peter J Blankestijn, Marianne C Verhaar, Willem Jan W Bos, Friedo W Dekker, Merel van Diepen
Background: Bleeding risk scores have been created to identify patients with an increased bleeding risk, which could also be useful in dialysis patients. However, the predictive performances of these bleeding risk scores in dialysis patients are unknown. Therefore, the aim of this study was to validate existing bleeding risk scores in dialysis patients. Methods: A cohort of 1745 incident dialysis patients was prospectively followed for 3 years during which bleeding events were registered...
January 4, 2019: Nephrology, Dialysis, Transplantation
Arnaud Devresse, Lise Morin, Florence Aulagnon, Jean-Luc Taupin, Anne Scemla, Fanny Lanternier, Olivier Aubert, Adel A Aidoud, Xavier Lebreton, Rebecca Sberro-Soussan, Renaud Snanoudj, Lucile Amrouche, Claire Tinel, Frank Martinez, Lynda Bererhi, Dany Anglicheau, Olivier Lortholary, Christophe Legendre, Véronique Avettand-Fenoel, Julien Zuber
Background: Diarrhoea is one of the most frequent complications after kidney transplantation (KT). Non-infectious diarrhoea has been associated with reduced graft survival in kidney transplant recipients. However, the risk factors for renal allograft loss following diarrhoea remain largely unknown. Methods: Between January 2010 and August 2011, 195 consecutive KT recipients who underwent standardized microbiological workups for diarrhoea at a single centre were enrolled in this retrospective study...
January 3, 2019: Nephrology, Dialysis, Transplantation
Anja Wilkening, Julia Krappe, Anne M Mühe, Maja T Lindenmeyer, Nuru Eltrich, Bruno Luckow, Volker Vielhauer
Background: Glomerulosclerosis and tubulointerstitial fibrosis are hallmarks of chronic kidney injury leading to end-stage renal disease. Inflammatory mechanisms contribute to glomerular and interstitial scarring, including chemokine-mediated recruitment of leucocytes. In particular, accumulation of C-C chemokine receptor type 2 (CCR2)-expressing macrophages promotes renal injury and fibrotic remodelling in diseases like glomerulonephritis and diabetic nephropathy. The functional role of CCR2 in the initiation and progression of primary glomerulosclerosis induced by podocyte injury remains to be characterized...
December 28, 2018: Nephrology, Dialysis, Transplantation
Rogier Caluwé, Francis Verbeke, An S De Vriese
The cardinal biological role of vitamin K is to act as cofactor for the carboxylation of a number of vitamin K-dependent proteins, some of which are essential for coagulation, bone formation and prevention of vascular calcification. Functional vitamin K deficiency is common and severe among dialysis patients and has garnered attention as a modifiable risk factor in this population. However, no single biochemical parameter can adequately assess vitamin K status. For each biological function of vitamin K, the degree of carboxylation of the relevant vitamin K-dependent protein most accurately reflects vitamin K status...
December 26, 2018: Nephrology, Dialysis, Transplantation
Ruifeng Wang, Titi Chen, Chengshi Wang, Zhiqiang Zhang, Xin Maggie Wang, Qing Li, Vincent W S Lee, Yuan Min Wang, Guoping Zheng, Stephen I Alexander, Yiping Wang, David C H Harris, Qi Cao
Background: Chronic kidney disease (CKD) is a global public health problem, which lacks effective treatment. Previously, we have shown that CD103+ dendritic cells (DCs) are pathogenic in adriamycin nephropathy (AN), a model of human focal segmental glomerulosclerosis (FSGS). Fms-like tyrosine kinase 3 (Flt3) is a receptor that is expressed with high specificity on tissue resident CD103+ DCs. Methods: To test the effect on CD103+ DCs and kidney injury of inhibition of Flt3, we used a selective Flt3 inhibitor (AC220) to treat mice with AN...
December 26, 2018: Nephrology, Dialysis, Transplantation
Louise Salomo, Marianne Rix, Anne-Lise Kamper, Jesper Q Thomassen, Jens J Sloth, Arne Astrup
Background: The New Nordic Diet is a food concept favouring organically produced food items, fruits, vegetables, whole grains and fish. We investigated the short-term effects of a modified phosphorus-reduced New Nordic Renal Diet (NNRD) in chronic kidney disease (CKD) patients on important parameters of phosphorus homoeostasis. Methods: The NNRD contained a total of 850 mg phosphorus/day. A total of 18 patients, CKD Stages 3 and 4 were studied in a randomized crossover trial comparing a 1-week control period of the habitual diet with a 1-week period of the NNRD...
December 24, 2018: Nephrology, Dialysis, Transplantation
Eduardo Gomes Lima, David M Charytan, Whady Hueb, Diogo Freitas Cardoso de Azevedo, Cibele Larrosa Garzillo, Desiderio Favarato, Jaime Paula Pessoa Linhares Filho, Eduardo Bello Martins, Daniel Valente Batista, Paulo Cury Rezende, Alexandre Ciappina Hueb, José Antonio Franchini Ramires, Roberto Kalil Filho
Background: Chronic kidney disease (CKD) is associated with a worse prognosis in patients with stable coronary artery disease (CAD); however, there is limited randomized data on long-term outcomes of CAD therapies in these patients. We evaluated long-term outcomes of CKD patients with CAD who underwent randomized therapy with medical treatment (MT) alone, percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). Methods: Baseline estimated glomerular filtration rate (eGFR) was obtained in 611 patients randomized to one of three therapeutic strategies in the Medicine, Angioplasty, or Surgery Study II trial...
December 24, 2018: Nephrology, Dialysis, Transplantation
Marcel P B Jansen, Wilco P C Pulskens, Melissa Uil, Nike Claessen, Gerrie Nieuwenhuizen, Dorien Standaar, Chi M Hau, Rienk Nieuwland, Sandrine Florquin, Frederike J Bemelman, Jaklien C Leemans, Joris J T H Roelofs
Background: Ischaemia-reperfusion (IR) injury is an important determinant of delayed graft function (DGF) affecting allograft function. Mitochondrial DNA (mtDNA) is released upon cell death and platelet activation into the extracellular environment and has been suggested to be a biomarker in several diseases. Whether extracellular mtDNA accumulates in plasma and/or urine upon renal IR and predisposes DGF is unknown. Methods: C57BL/6J wild-type mice were subjected to renal IR...
December 24, 2018: Nephrology, Dialysis, Transplantation
Ying Yang, Xiaojian Feng, Xinyan Liu, Ying Wang, Min Hu, Qi Cao, Ziyan Zhang, Linxia Zhao, Jianlin Zhang, Rui Guo, Hailong Wang, Xi Qiao, Lihua Wang, Guoping Zheng
Background: Renal fibrosis is a key pathological feature and final common pathway leading to end-stage kidney failure in many chronic kidney diseases. Myofibroblast is the master player in renal fibrosis. However, myofibroblasts are heterogeneous. Recent studies show that bone marrow-derived macrophages transform into myofibroblasts by transforming growth factor (TGF)-β-induced macrophage-myofibroblast transition (MMT) in renal fibrosis. Methods: TGF-β signaling was redirected by inhibition of β-catenin/T-cell factor (TCF) to increase β-catenin/Foxo in bone marrow-derived macrophages...
December 24, 2018: Nephrology, Dialysis, Transplantation
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