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Nature Reviews. Clinical Oncology

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https://www.readbyqxmd.com/read/29311715/the-bone-marrow-niche-in-mds-and-mgus-implications-for-aml-and-mm
#1
REVIEW
Irene M Ghobrial, Alexandre Detappe, Kenneth C Anderson, David P Steensma
Several haematological malignancies, including multiple myeloma (MM) and acute myeloid leukaemia (AML), have well-defined precursor states that precede the development of overt cancer. MM is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS), and at least a quarter of all patients with myelodysplastic syndromes (MDS) have disease that evolves into AML. In turn, MDS are frequently anteceded by clonal haematopoiesis of indeterminate potential (CHIP). The acquisition of additional genetic and epigenetic alterations over time clearly influences the increasingly unstable and aggressive behaviour of neoplastic haematopoietic clones; however, perturbations in the bone-marrow microenvironment are increasingly recognized to have key roles in initiating and supporting oncogenesis...
January 9, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29297507/immunotherapy-hla-1-genotype-influences-response-to-checkpoint-inhibitors
#2
Peter Sidaway
No abstract text is available yet for this article.
January 3, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29297506/haematological-cancer-favourable-outcomes-with-car-t-cells
#3
Diana Romero
No abstract text is available yet for this article.
January 3, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29297505/determinants-and-clinical-implications-of-chromosomal-instability-in-cancer
#4
REVIEW
Laurent Sansregret, Bart Vanhaesebroeck, Charles Swanton
Aberrant chromosomal architecture, ranging from small insertions or deletions to large chromosomal alterations, is one of the most common characteristics of cancer genomes. Chromosomal instability (CIN) underpins much of the intratumoural heterogeneity observed in cancers and drives phenotypic adaptation during tumour evolution. Thus, an urgent need exists to increase our efforts to target CIN as if it were a molecular entity. Indeed, CIN accelerates the development of anticancer drug resistance, often leading to treatment failure and disease recurrence, which limit the effectiveness of most current therapies...
January 3, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29283170/perioperative-events-influence-cancer-recurrence-risk-after-surgery
#5
REVIEW
Jonathan G Hiller, Nicholas J Perry, George Poulogiannis, Bernhard Riedel, Erica K Sloan
Surgery is a mainstay treatment for patients with solid tumours. However, despite surgical resection with a curative intent and numerous advances in the effectiveness of (neo)adjuvant therapies, metastatic disease remains common and carries a high risk of mortality. The biological perturbations that accompany the surgical stress response and the pharmacological effects of anaesthetic drugs, paradoxically, might also promote disease recurrence or the progression of metastatic disease. When cancer cells persist after surgery, either locally or at undiagnosed distant sites, neuroendocrine, immune, and metabolic pathways activated in response to surgery and/or anaesthesia might promote their survival and proliferation...
December 28, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29283169/haematological-cancer-brentuximab-effective-in-untreated-hodgkin-lymphoma
#6
Peter Sidaway
No abstract text is available yet for this article.
December 28, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255241/prostate-cancer-genomic-information-improves-risk-prediction
#7
Diana Romero
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255240/bladder-cancer-multi-omic-profiling-refines-the-molecular-view
#8
Carolyn D Hurst, Margaret A Knowles
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255239/the-evidence-framework-for-precision-cancer-medicine
#9
REVIEW
Jeffrey A Moscow, Tito Fojo, Richard L Schilsky
Precision cancer medicine (PCM) is a concept in which oncologists increasingly strive to tailor the use of targeted therapies in order to match the complexity of the cancer genome. This approach contradicts the historical framework used to support oncology practice that requires evidence from randomized controlled trials in order to change standards of care. This contrast demonstrates the irony of PCM: the therapies themselves are more precise than standard cytotoxic agents, although the clinical evidence supporting the benefits of these therapies is often considerably less precise...
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255238/acute-lymphoblastic-leukaemia-in-2017-immunotherapy-for-all-takes-the-world-by-storm
#10
David T Teachey, Stephen P Hunger
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255237/palliative-care-anamorelin-provides-benefit-to-patients-with-cachexia
#11
Peter Sidaway
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255236/lung-cancer-osna-enables-more-accurate-detection-of-micrometastases
#12
Peter Sidaway
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29255235/immunotherapy-dmmr-presents-opportunities-to-enhance-immunotherapy
#13
David Killock
No abstract text is available yet for this article.
December 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29231194/breast-cancer-in-2017-spurring-science-marking-progress-and-influencing-history
#14
Jose Perez-Garcia, Javier Cortes
No abstract text is available yet for this article.
December 12, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29231193/pancreatic-cancer-mass-spectrometry-indicates-malignant-potential
#15
Peter Sidaway
No abstract text is available yet for this article.
December 12, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29203837/urothelial-cancer-in-2017-changes-in-expectations-for-metastatic-urothelial-carcinoma
#16
Joaquim Bellmunt, Rosa Nadal
No abstract text is available yet for this article.
December 5, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29182165/me-too-drugs-with-limited-benefits-the-tale-of-regorafenib-for-hcc
#17
Bishal Gyawali, Vinay Prasad
This corrects the article DOI: 10.1038/nrclinonc.2017.100.
November 28, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29182164/targeting-ret-driven-cancers-lessons-from-evolving-preclinical-and-clinical-landscapes
#18
Alexander Drilon, Zishuo I Hu, Gillianne G Y Lai, Daniel S W Tan
This corrects the article DOI: 10.1038/nrclinonc.2017.175.
November 28, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29182163/immunotherapy-relying-on-quality-over-quantity
#19
Diana Romero
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29182162/melanoma-in-2017-moving-treatments-earlier-to-move-further-forwards
#20
Michael A Davies, Keith T Flaherty
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Clinical Oncology
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