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Nature Reviews. Clinical Oncology

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https://www.readbyqxmd.com/read/28397828/emt-cscs-and-drug-resistance-the-mechanistic-link-and-clinical-implications
#1
REVIEW
Tsukasa Shibue, Robert A Weinberg
The success of anticancer therapy is usually limited by the development of drug resistance. Such acquired resistance is driven, in part, by intratumoural heterogeneity - that is, the phenotypic diversity of cancer cells co-inhabiting a single tumour mass. The introduction of the cancer stem cell (CSC) concept, which posits the presence of minor subpopulations of CSCs that are uniquely capable of seeding new tumours, has provided a framework for understanding one dimension of intratumoural heterogeneity. This concept, taken together with the identification of the epithelial-to-mesenchymal transition (EMT) programme as a critical regulator of the CSC phenotype, offers an opportunity to investigate the nature of intratumoural heterogeneity and a possible mechanistic basis for anticancer drug resistance...
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28397827/cns-cancer-new-chemoradiation-standard-for-elderly-patients-with-glioblastoma
#2
Lisa Hutchinson
No abstract text is available yet for this article.
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28397826/immunotherapy-hiding-in-plain-sight-immune-escape-in-the-era-of-targeted-t-cell-based-immunotherapies
#3
Anthony F Daniyan, Renier J Brentjens
No abstract text is available yet for this article.
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28397825/gynaecological-cancer-novel-molecular-subtypes-of-cervical-cancer-potential-clinical-consequences
#4
Chris J L M Meijer, Renske D M Steenbergen
No abstract text is available yet for this article.
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28397824/haematological-cancer-dual-targeting-to-defeat-resistance
#5
Diana Romero
No abstract text is available yet for this article.
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28397823/tumour-microenvironment-informing-on-minimal-residual-disease-in-solid-tumours
#6
Klaus Pantel, Catherine Alix-Panabières
No abstract text is available yet for this article.
April 11, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28374786/targeted-agents-and-immunotherapies-optimizing-outcomes-in-melanoma
#7
REVIEW
Jason J Luke, Keith T Flaherty, Antoni Ribas, Georgina V Long
Treatment options for patients with metastatic melanoma, and especially BRAF-mutant melanoma, have changed dramatically in the past 5 years, with the FDA approval of eight new therapeutic agents. During this period, the treatment paradigm for BRAF-mutant disease has evolved rapidly: the standard-of-care BRAF-targeted approach has shifted from single-agent BRAF inhibition to combination therapy with a BRAF and a MEK inhibitor. Concurrently, immunotherapy has transitioned from cytokine-based treatment to antibody-mediated blockade of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and, now, the programmed cell-death protein 1 (PD-1) immune checkpoints...
April 4, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28374784/targeting-c-met-in-gastrointestinal-tumours-rationale-opportunities-and-challenges
#8
REVIEW
Conor A Bradley, Manuel Salto-Tellez, Pierre Laurent-Puig, Alberto Bardelli, Christian Rolfo, Josep Tabernero, Hajrah A Khawaja, Mark Lawler, Patrick G Johnston, Sandra Van Schaeybroeck
Data from many preclinical studies, including those using cellular models of colorectal, gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the hepatocyte growth factor (HGF)-hepatocyte growth factor receptor (c-MET) pathway is vital for the growth, survival and invasive potential of gastrointestinal cancers. Following the availability of data from these various studies, and data on c-MET expression as a biomarker that indicates a poor prognosis in patients with gastrointestinal cancer and increased c-MET expression, inhibitors targeting this pathway have entered the clinic in the past decade...
April 4, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28352131/drug-therapy-exploiting-synthetic-lethality-to-improve-cancer-therapy
#9
Diede Brunen, René Bernards
No abstract text is available yet for this article.
March 29, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28290490/the-high-price-of-anticancer-drugs-origins-implications-barriers-solutions
#10
REVIEW
Vinay Prasad, Kevin De Jesús, Sham Mailankody
Globally, annual spending on anticancer drugs is around US$100 billion, and is predicted to rise to $150 billion by 2020. In the USA, a novel anticancer drug routinely costs more than $100,000 per year of treatment. When adjusted for per capita spending power, however, drugs are most unaffordable in economically developing nations, such as India and China. Not only are launch prices high and rising, but individual drug prices are often escalated during exclusivity periods. High drug prices harm patients - often directly through increased out-of-pocket expenses, which reduce levels of patient compliance and lead to unfavourable outcomes - and harms society - by imposing cumulative price burdens that are unsustainable...
March 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28290489/charged-particle-therapy-in-cancer-clinical-uses-and-future-perspectives
#11
REVIEW
Marco Durante, Roberto Orecchia, Jay S Loeffler
Radiotherapy with high-energy charged particles has become an attractive therapeutic option for patients with several tumour types because this approach better spares healthy tissue from radiation than conventional photon therapy. The cost associated with the delivery of charged particles, however, is higher than that of even the most elaborate photon-delivery technologies. Reliable evidence of the relative cost-effectiveness of both modalities can only come from the results of randomized clinical trials. Thus, the hurdles that currently limit direct comparisons of these two approaches in clinical trials, especially those related to insurance coverage, should be removed...
March 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28252003/integrating-liquid-biopsies-into-the-management-of-cancer
#12
REVIEW
Giulia Siravegna, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
During cancer progression and treatment, multiple subclonal populations of tumour cells compete with one another, with selective pressures leading to the emergence of predominant subclones that replicate and spread most proficiently, and are least susceptible to treatment. At present, the molecular landscapes of solid tumours are established using surgical or biopsy tissue samples. Tissue-based tumour profiles are, however, subject to sampling bias, provide only a snapshot of tumour heterogeneity, and cannot be obtained repeatedly...
March 2, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28195238/the-changing-landscape-of-clinical-trial-and-approval-processes-in-china
#13
REVIEW
Qing Zhou, Xiao-Yuan Chen, Zhi-Min Yang, Yi-Long Wu
In the past decade, the standards of clinical trials in China have moved closer to international standards, thus encouraging the development of innovative drugs. However, a large backlog of pending applications for both drug approval and clinical trial registration has arisen owing to the complexity of the approval process, the volume of applications and a lack of staff available to process these applications, among other reasons. To improve the drug approval process, a 'four-colour-light' strategy was introduced...
February 14, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28422116/skin-cancer-have-melanoma-and-skin-cancer-finally-met-their-match
#14
Jeffrey E Gershenwald, Kelly C Nelson
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28422115/cancer-obesity-and-diabetes-tkis-exert-multiple-effects-on-glucose-homeostasis
#15
Minglin Lin, Junfei Jin
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28422114/cancer-obesity-and-diabetes-tkis-exert-multiple-effects-on-glucose-homeostasis
#16
Michael N Pollak
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28374788/prostate-cancer-clinical-hallmarks-in-whole-cancer-genomes
#17
Marcin Imielinski, Mark A Rubin
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28374787/is-there-a-right-not-to-know
#18
Devan Stahl, Tom Tomlinson
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28374785/haematological-cancers-promising-epigenetic-targets-in-leukaemia-identified
#19
Lisa Hutchinson
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28352133/haematological-cancer-anti-pd-1-therapy-with-nivolumab-after-allo-hsct-for-hodgkin-lymphoma
#20
David Killock
No abstract text is available yet for this article.
May 2017: Nature Reviews. Clinical Oncology
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