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Nature Reviews. Clinical Oncology

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https://www.readbyqxmd.com/read/28925996/colorectal-cancer-liquid-biopsy-provides-highly-sensitive-detection-of-ras-mutations
#1
Peter Sidaway
No abstract text is available yet for this article.
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28925995/immunotherapy-shining-light-on-immune-based-mechanisms
#2
Lisa Hutchinson
No abstract text is available yet for this article.
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28925994/chimeric-antigen-receptor-t-cell-therapy-assessment-and-management-of-toxicities
#3
REVIEW
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver, Jason Westin, Alison M Gulbis, Monica E Loghin, John F de Groot, Sherry Adkins, Suzanne E Davis, Katayoun Rezvani, Patrick Hwu, Elizabeth J Shpall
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor (CAR) is rapidly emerging as a promising new treatment for haematological and non-haematological malignancies. CAR-T-cell therapy can induce rapid and durable clinical responses, but is associated with unique acute toxicities, which can be severe or even fatal. Cytokine-release syndrome (CRS), the most commonly observed toxicity, can range in severity from low-grade constitutional symptoms to a high-grade syndrome associated with life-threatening multiorgan dysfunction; rarely, severe CRS can evolve into fulminant haemophagocytic lymphohistiocytosis (HLH)...
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28925993/targeted-therapies-survival-endeavors
#4
Lisa Hutchinson
No abstract text is available yet for this article.
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28895572/manifesto-for-global-women-s-health
#5
Ophira Ginsburg
No abstract text is available yet for this article.
September 12, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28895571/corrigendum-can-we-deliver-randomized-trials-of-focal-therapy-in-prostate-cancer
#6
Hashim U Ahmed, Viktor Berge, David Bottomley, William Cross, Rakesh Heer, Richard Kaplan, Tom Leslie, Chris Parker, Clare Relton, Richard Stephens, Matthew R Sydes, Lindsay Turnbull, Jan van der Meulen, Andrew Vickers, Timothy Wilt, Mark Emberton
No abstract text is available yet for this article.
September 12, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28895570/immunotherapy-cancer-vaccines-on-the-move
#7
Jacques Banchereau, Karolina Palucka
No abstract text is available yet for this article.
September 12, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857079/immunotherapy-crispr-unveils-t-cell-resistance-mechanisms-in-tumours
#8
Lisa Hutchinson
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857078/cell-signalling-even-kinase-inactive-braf-is-oncogenic
#9
David Killock
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857077/fusions-in-solid-tumours-diagnostic-strategies-targeted-therapy-and-acquired-resistance
#10
REVIEW
Alison M Schram, Matthew T Chang, Philip Jonsson, Alexander Drilon
Structural gene rearrangements resulting in gene fusions are frequent events in solid tumours. The identification of certain activating fusions can aid in the diagnosis and effective treatment of patients with tumours harbouring these alterations. Advances in the techniques used to identify fusions have enabled physicians to detect these alterations in the clinic. Targeted therapies directed at constitutively activated oncogenic tyrosine kinases have proven remarkably effective against cancers with fusions involving ALK, ROS1, or PDGFB, and the efficacy of this approach continues to be explored in malignancies with RET, NTRK1/2/3, FGFR1/2/3, and BRAF/CRAF fusions...
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857076/breast-cancer-evolution-of-metastatic-disease-revealed
#11
Peter Sidaway
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857075/chimeric-antigen-receptor-t-cell-therapies-for-lymphoma
#12
REVIEW
Jennifer N Brudno, James N Kochenderfer
New therapies are needed for patients with Hodgkin or non-Hodgkin lymphomas that are resistant to standard therapies. Indeed, unresponsiveness to standard chemotherapy and relapse after autologous stem-cell transplantation are indicators of an especially poor prognosis. Chimeric antigen receptor (CAR) T cells are emerging as a novel treatment modality for these patients. Clinical trial data have demonstrated the potent activity of anti-CD19 CAR T cells against multiple subtypes of B-cell lymphoma, including diffuse large-B-cell lymphoma (DLBCL), follicular lymphoma, mantle-cell lymphoma, and marginal-zone lymphoma...
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857074/breast-cancer-akt-inhibition-effective-against-tnbc
#13
Peter Sidaway
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857073/pancreatic-cancer-tcga-data-reveal-a-highly-heterogeneous-disease
#14
Peter Sidaway
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28857072/brain-cancer-temozolomide-improves-outcomes
#15
Peter Sidaway
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28829058/evolution-and-cancer-medicine-transformative-insights
#16
Erik Sahai, Charles Swanton
No abstract text is available yet for this article.
August 22, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28786416/breast-cancer-t-dm1-an-important-agent-in-the-history-of-breast-cancer-management
#17
Otto Metzger-Filho, Eric P Winer
No abstract text is available yet for this article.
August 8, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28786414/breast-cancer-what-lies-beyond-aphinity-for-her2-positive-breast-cancer
#18
Sasha E Stanton, Nancy E Davidson
No abstract text is available yet for this article.
August 8, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28762384/her2-positive-breast-cancer-is-lost-in-translation-time-for-patient-centered-research
#19
REVIEW
Isabelle Gingras, GĂ©raldine Gebhart, Evandro de Azambuja, Martine Piccart-Gebhart
No biomarker beyond HER2 itself, which suffers from a low positive predictive value, has demonstrated clinical utility in breast cancer, despite numerous attempts to improve treatment tailoring for the growing number of anti-HER2 targeted therapies. This prompted us to examine the body of evidence, using a systematic approach, to identify putative predictive biomarkers in HER2-positive breast cancer, and discuss the hitherto failure to address the needs of patients. In the future, it is hoped immune-based biomarkers will predict benefit from anti-HER2 treatments in the neoadjuvant and adjuvant settings...
August 1, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28741619/pancreatic-cancer-egfr-inhibition-is-effective-against-kras-wild-type-disease
#20
Peter Sidaway
No abstract text is available yet for this article.
July 25, 2017: Nature Reviews. Clinical Oncology
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