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New England Journal of Medicine

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https://www.readbyqxmd.com/read/30021079/radical-changes-for-reproductive-health-care-proposed-regulations-for-title-x
#1
Janet M Bronstein
On June 1, 2018, the Department of Health and Human Services (HHS) proposed new regulations for the Title X Family Planning Program. If enacted, these regulations will radically alter the mix of health care providers and the range, quality, and effectiveness of services offered to support the..
July 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30021078/testing-epinephrine-for-out-of-hospital-cardiac-arrest
#2
Clifton W Callaway, Michael W Donnino
No abstract text is available yet for this article.
July 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30021076/a-randomized-trial-of-epinephrine-in-out-of-hospital-cardiac-arrest
#3
Gavin D Perkins, Chen Ji, Charles D Deakin, Tom Quinn, Jerry P Nolan, Charlotte Scomparin, Scott Regan, John Long, Anne Slowther, Helen Pocock, John J M Black, Fionna Moore, Rachael T Fothergill, Nigel Rees, Lyndsey O'Shea, Mark Docherty, Imogen Gunson, Kyee Han, Karl Charlton, Judith Finn, Stavros Petrou, Nigel Stallard, Simon Gates, Ranjit Lall
Background Concern about the use of epinephrine as a treatment for out-of-hospital cardiac arrest led the International Liaison Committee on Resuscitation to call for a placebo-controlled trial to determine whether the use of epinephrine is safe and effective in such patients. Methods In a randomized, double-blind trial involving 8014 patients with out-of-hospital cardiac arrest in the United Kingdom, paramedics at five National Health Service ambulance services administered either parenteral epinephrine (4015 patients) or saline placebo (3999 patients), along with standard care...
July 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30020849/parenteral-opioid-shortage-treating-pain-during-the-opioid-overdose-epidemic
#4
Eduardo Bruera
The opioid-overdose epidemic now causes more than 30,000 deaths per year in the United States. In response to the increasing death toll, many measures have recently been implemented, including reclassification of hydrocodone as a Schedule II opioid and new requirements for physician review of..
July 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30020848/a-remembrance-of-life-before-roe-v-wade
#5
Julie R Ingelfinger
We chatted as the dialysis shift began. She was a young nursing student whose name and face I still remember five decades later, but I will just call her "Jane Roe." She was from the Virgin Islands and had come to New York for nursing school. She was nearly done — justifiably proud, since she had..
July 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29996065/behind-schedule-reconciling-federal-and-state-marijuana-policy
#6
Rebecca L Haffajee, Robert J MacCoun, Michelle M Mello
The long-standing chasm between federal and state marijuana policy recently widened when U.S. Attorney General Jeff Sessions rescinded Obama-era guidance indicating that the Justice Department would not make it a priority to prosecute federal marijuana crimes in states where the activities are..
July 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29995594/life-lessons-from-paul-in-the-face-of-death
#7
Jeffrey M Drazen
No abstract text is available yet for this article.
July 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29995585/fractional-dose-yellow-fever-vaccination-advancing-the-evidence-base
#8
Kirsten Vannice, Annelies Wilder-Smith, Joachim Hombach
In 2016, a global shortage of yellow fever vaccine occurred as a result of major yellow fever outbreaks in Angola and the Democratic Republic of Congo (DRC). By October, 7136 cases and 493 deaths were reported in the two countries. Reactive vaccination campaigns were conducted in areas with..
July 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29949473/heat-stable-carbetocin-versus-oxytocin-to-prevent-hemorrhage-after-vaginal-birth
#9
Mariana Widmer, Gilda Piaggio, Thi M H Nguyen, Alfred Osoti, Olorunfemi O Owa, Sujata Misra, Arri Coomarasamy, Hany Abdel-Aleem, Ashalata A Mallapur, Zahida Qureshi, Pisake Lumbiganon, Archana B Patel, Guillermo Carroli, Bukola Fawole, Shivaprasad S Goudar, Yeshita V Pujar, James Neilson, G Justus Hofmeyr, Lin L Su, Jose Ferreira de Carvalho, Uma Pandey, Kidza Mugerwa, Shobha S Shiragur, Josaphat Byamugisha, Daniel Giordano, A Metin Gülmezoglu
Background Postpartum hemorrhage is the most common cause of maternal death. Oxytocin is the standard therapy for the prevention of postpartum hemorrhage, but it requires cold storage, which is not available in many countries. In a large trial, we compared a novel formulation of heat-stable carbetocin with oxytocin. Methods We enrolled women across 23 sites in 10 countries in a randomized, double-blind, noninferiority trial comparing intramuscular injections of heat-stable carbetocin (at a dose of 100 μg) with oxytocin (at a dose of 10 IU) administered immediately after vaginal birth...
June 27, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29949451/accreditation-of-clinical-research-sites-moving-forward
#10
Greg Koski, Larry Kennedy, Mary F Tobin, Matthew Whalen
Accreditation is used in many fields, including education, travel, construction, and health care. When implemented correctly, it improves quality, performance, and safety, while signaling to the public that an accredited entity is committed to an agreed-on set of values. Key to its effectiveness is..
June 27, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29949446/firearm-injuries-and-violence-prevention-the-potential-power-of-a-surgeon-general-s-report
#11
John Maa, Ara Darzi
In the aftermath of the mass shooting at a social services center in San Bernardino, California, in 2015, President Barack Obama suggested that the relationship between firearm ownership and gun injuries might be as strong as the connection between cigarette smoking and lung cancer. The full extent..
June 27, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29943666/recurrent-glioblastoma-treated-with-recombinant-poliovirus
#12
Annick Desjardins, Matthias Gromeier, James E Herndon, Nike Beaubier, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Smita Nair, Katherine B Peters, Dina Randazzo, John H Sampson, Gordana Vlahovic, William T Harrison, Roger E McLendon, David Ashley, Darell D Bigner
Background The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted a dose-finding and toxicity study in this population of patients, evaluating convection-enhanced, intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera (PVSRIPO). PVSRIPO recognizes the poliovirus receptor CD155, which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment...
June 26, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29943655/exploiting-viruses-to-treat-diseases
#13
Dan L Longo, Lindsey R Baden
New England Journal of Medicine, Volume 379, Issue 2, Page 194-196, July 2018.
June 26, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29940126/closed-loop-insulin-delivery-for-glycemic-control-in-noncritical-care
#14
Lia Bally, Hood Thabit, Sara Hartnell, Eveline Andereggen, Yue Ruan, Malgorzata E Wilinska, Mark L Evans, Maria M Wertli, Anthony P Coll, Christoph Stettler, Roman Hovorka
Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in patients with type 1 diabetes. We wanted to investigate whether a closed-loop system could also improve glycemic control in patients with type 2 diabetes who were receiving noncritical care. Methods In this randomized, open-label trial conducted on general wards in two tertiary hospitals located in the United Kingdom and Switzerland, we assigned 136 adults with type 2 diabetes who required subcutaneous insulin therapy to receive either closed-loop insulin delivery (70 patients) or conventional subcutaneous insulin therapy, according to local clinical practice (66 patients)...
June 25, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29932842/the-suffering-of-children
#15
Fiona Danaher
Every pediatrician has his or her own tips for putting young patients at ease in the exam room. Mine include referring to even the tiniest Spanish-speaking patients as usted rather than tú, as a sign of respect, and sitting at or below their level to avoid looming over them. Most important, I..
June 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29932841/housing-immigrant-children-the-inhumanity-of-constant-illumination
#16
Charles A Czeisler
On the Wednesday before the summer solstice in the United States, President Donald Trump ended his administration’s policy of forced separation of immigrant children from their parents at the U.S.–Mexico border — a practice characterized by the president of the American Academy of Pediatrics (AAP)..
June 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29924700/to-fight-burnout-organize
#17
Leo Eisenstein
No abstract text is available yet for this article.
June 20, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29924688/sociogenetic-risks-ancestry-dna-testing-third-party-identity-and-protection-of-privacy
#18
Thomas May
The recent capture of the suspected Golden State Killer on "National DNA Day" was a startling public illustration of the reality that DNA information may be pertinent to people far removed from the one who was tested — and the fact that information may derive from testing that an implicated person..
June 20, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29898375/effect-of-bronchoconstriction-on-airway-remodeling-in-asthma
#19
(no author information available yet)
New England Journal of Medicine, Volume 378, Issue 25, Page 2450-2450, June 2018.
June 13, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29898374/extended-antiretroviral-prophylaxis-to-reduce-breast-milk-hiv-1-transmission
#20
(no author information available yet)
New England Journal of Medicine, Volume 378, Issue 25, Page 2450-2450, June 2018.
June 13, 2018: New England Journal of Medicine
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