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New England Journal of Medicine

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https://www.readbyqxmd.com/read/28813211/a-nicotine-focused-framework-for-public-health
#1
Scott Gottlieb, Mitchell Zeller
Despite extraordinary progress in tobacco control and prevention, tobacco use remains the leading cause of preventable disease and death in the United States. Combustible cigarettes cause the overwhelming majority of tobacco-related disease and are responsible for more than 480,000 U.S. deaths each..
August 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813210/public-opinion-about-the-future-of-the-affordable-care-act
#2
Robert J Blendon, John M Benson
In the early hours of Friday, July 28, the U.S. Senate closed debate on repealing and replacing the Affordable Care Act (ACA) without the passage of any piece of legislation and after rejecting the replacement bill previously passed by the House of Representatives. This public-opinion analysis..
August 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792849/olaparib-for-metastatic-breast-cancer-in-patients-with-a-germline-brca-mutation
#3
(no author information available yet)
No abstract text is available yet for this article.
August 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792848/small-change-big-consequences-partial-medicaid-expansions-under-the-aca
#4
Adrianna McIntyre, Allan M Joseph, Nicholas Bagley
Though congressional efforts to repeal and replace the Affordable Care Act (ACA) seem to have stalled, the Trump administration retains broad executive authority to reshape the health care landscape. Perhaps the most consequential choices that the administration will make pertain to Medicaid, which..
August 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792847/repeal-replace-repair-retreat-republicans-health-care-quagmire
#5
Jonathan Oberlander
For 7 years, Republicans vowed to repeal and replace the Affordable Care Act (ACA). With Donald Trump in the White House and Republican majorities in Congress, the GOP was poised to make good on that pledge. Yet less than 7 months into the Trump administration, the GOP’s crusade to dismantle..
August 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28708020/from-last-to-first-could-the-u-s-health-care-system-become-the-best-in-the-world
#6
Eric C Schneider, David Squires
Many Americans believe that the United States has the best health care system in the world, but surprisingly little evidence supports that belief. On the contrary, since 2004, reports from the Commonwealth Fund have consistently ranked the performance of the U.S. health care system last among..
July 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28700269/threats-to-information-security-public-health-implications
#7
William J Gordon, Adam Fairhall, Adam Landman
In health care, information security has classically been regarded as an administrative nuisance, a regulatory hurdle, or a simple privacy matter. But the recent "WannaCry" and "Petya" ransomware attacks have wreaked havoc by disabling organizations worldwide, including parts of England’s National..
July 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28700263/adjuvant-pertuzumab-and-trastuzumab-in-early-her2-positive-breast-cancer
#8
(no author information available yet)
No abstract text is available yet for this article.
July 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28691885/targeting-of-antithrombin-in-hemophilia-a-or-b-with-rnai-therapy
#9
K John Pasi, Savita Rangarajan, Pencho Georgiev, Tim Mant, Michael D Creagh, Toshko Lissitchkov, David Bevan, Steve Austin, Charles R Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Liana Gercheva-Kyuchukova, Vasily Mamonov, Margarita Timofeeva, Chang-Heok Soh, Pushkal Garg, Akshay Vaishnaw, Akin Akinc, Benny Sørensen, Margaret V Ragni
Background Current hemophilia treatment involves frequent intravenous infusions of clotting factors, which is associated with variable hemostatic protection, a high treatment burden, and a risk of the development of inhibitory alloantibodies. Fitusiran, an investigational RNA interference (RNAi) therapy that targets antithrombin (encoded by SERPINC1), is in development to address these and other limitations. Methods In this phase 1 dose-escalation study, we enrolled 4 healthy volunteers and 25 participants with moderate or severe hemophilia A or B who did not have inhibitory alloantibodies...
July 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28691560/bispecific-antibody-therapy-in-hemophilia
#10
David Lillicrap
No abstract text is available yet for this article.
July 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28691557/emicizumab-prophylaxis-in-hemophilia-a-with-inhibitors
#11
Johannes Oldenburg, Johnny N Mahlangu, Benjamin Kim, Christophe Schmitt, Michael U Callaghan, Guy Young, Elena Santagostino, Rebecca Kruse-Jarres, Claude Negrier, Craig Kessler, Nancy Valente, Elina Asikanius, Gallia G Levy, Jerzy Windyga, Midori Shima
Background Emicizumab (ACE910) bridges activated factor IX and factor X to restore the function of activated factor VIII, which is deficient in persons with hemophilia A. This phase 3, multicenter trial assessed once-weekly subcutaneous emicizumab prophylaxis in persons with hemophilia A with factor VIII inhibitors. Methods We enrolled participants who were 12 years of age or older. Those who had previously received episodic treatment with bypassing agents were randomly assigned in a 2:1 ratio to emicizumab prophylaxis (group A) or no prophylaxis (group B)...
July 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28654356/health-wealth-and-the-u-s-senate
#12
Debra Malina, Stephen Morrissey, Mary Beth Hamel, Caren G Solomon, Arnold M Epstein, Edward W Campion, Jeffrey M Drazen
The Better Care Reconciliation Act (BCRA), as the U.S. Senate calls the health care bill released by a small working group of Republican senators last week, is not designed to lead to better care for Americans. Like the House bill that was passed in early May, the American Health Care Act (AHCA),..
June 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28605603/efficacy-and-safety-of-degludec-versus-glargine-in-type-2-diabetes
#13
Steven P Marso, Darren K McGuire, Bernard Zinman, Neil R Poulter, Scott S Emerson, Thomas R Pieber, Richard E Pratley, Poul-Martin Haahr, Martin Lange, Kirstine Brown-Frandsen, Alan Moses, Simon Skibsted, Kajsa Kvist, John B Buse
Background Degludec is an ultralong-acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-to-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. Methods We randomly assigned 7637 patients with type 2 diabetes to receive either insulin degludec (3818 patients) or insulin glargine U100 (3819 patients) once daily between dinner and bedtime in a double-blind, treat-to-target, event-driven cardiovascular outcomes trial...
June 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28586279/alectinib-versus-crizotinib-in-untreated-alk-positive-non-small-cell-lung-cancer
#14
Solange Peters, D Ross Camidge, Alice T Shaw, Shirish Gadgeel, Jin S Ahn, Dong-Wan Kim, Sai-Hong I Ou, Maurice Pérol, Rafal Dziadziuszko, Rafael Rosell, Ali Zeaiter, Emmanuel Mitry, Sophie Golding, Bogdana Balas, Johannes Noe, Peter N Morcos, Tony Mok
Background Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has shown systemic and central nervous system (CNS) efficacy in the treatment of ALK-positive non-small-cell lung cancer (NSCLC). We investigated alectinib as compared with crizotinib in patients with previously untreated, advanced ALK-positive NSCLC, including those with asymptomatic CNS disease. Methods In a randomized, open-label, phase 3 trial, we randomly assigned 303 patients with previously untreated, advanced ALK-positive NSCLC to receive either alectinib (600 mg twice daily) or crizotinib (250 mg twice daily)...
June 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813228/acute-ocular-graft-versus-host-disease
#15
Regine Braun, Ernst Holler
A 21-year-old man with refractory acute myeloid leukemia presented with itching and tearing in both eyes 1 month after receiving a hematopoietic stem-cell transplant from an HLA-mismatched, unrelated donor. Three weeks after transplantation, he received a diagnosis of grade 4 acute..
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813227/medical-education-in-the-era-of-alternative-facts
#16
Richard P Wenzel
New England Journal of Medicine, Volume 377, Issue 7, Page 607-609, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813226/trial-of-cannabidiol-for-drug-resistant-seizures-in-the-dravet-syndrome
#17
(no author information available yet)
New England Journal of Medicine, Volume 377, Issue 7, Page 699-700, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813225/pediatric-intestinal-failure
#18
Christopher P Duggan, Tom Jaksic
New England Journal of Medicine, Volume 377, Issue 7, Page 666-675, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813224/signs
#19
Caroline Wellbery
New England Journal of Medicine, Volume 377, Issue 7, Page 609-611, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813223/subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#20
LETTER
Brian M Casey, Elizabeth A Thom
New England Journal of Medicine, Volume 377, Issue 7, Page 700-701, August 2017.
August 17, 2017: New England Journal of Medicine
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