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EDITORIAL
Steve R Ommen
No abstract text is available yet for this article.
May 13, 2024: New England Journal of Medicine
#2
JOURNAL ARTICLE
Martin S Maron, Ahmad Masri, Michael E Nassif, Roberto Barriales-Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Claggett, Caroline J Coats, Hans-Dirk Düngen, Pablo Garcia-Pavia, Albert A Hagège, James L Januzzi, Matthew M Y Lee, Gregory D Lewis, Chang-Sheng Ma, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali T Owens, John A Spertus, Scott D Solomon, Jacob Tfelt-Hansen, Marion van Sinttruije, Josef Veselka, Hugh Watkins, Daniel L Jacoby, Stephen B Heitner, Stuart Kupfer, Fady I Malik, Lisa Meng, Amy Wohltman, Theodore P Abraham
BACKGROUND: One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. Aficamten is an oral selective cardiac myosin inhibitor that reduces left ventricular outflow tract gradients by mitigating cardiac hypercontractility. METHODS: In this phase 3, double-blind trial, we randomly assigned adults with symptomatic obstructive HCM to receive aficamten (starting dose, 5 mg; maximum dose, 20 mg) or placebo for 24 weeks, with dose adjustment based on echocardiography results...
May 13, 2024: New England Journal of Medicine
#3
JOURNAL ARTICLE
Sahil Sandhu, Rachel Landauer, Meryl C Katz, Laura M Gottlieb
No abstract text is available yet for this article.
May 11, 2024: New England Journal of Medicine
#4
JOURNAL ARTICLE
Shan Kai Ing, Sze Shyang Kho
No abstract text is available yet for this article.
May 11, 2024: New England Journal of Medicine
#5
JOURNAL ARTICLE
Alicia Fernandez, Marshall H Chin
No abstract text is available yet for this article.
May 11, 2024: New England Journal of Medicine
#6
JOURNAL ARTICLE
James A Feinstein
No abstract text is available yet for this article.
May 11, 2024: New England Journal of Medicine
#7
JOURNAL ARTICLE
Sam Halabi, Lawrence O Gostin, Olohikhuae Egbokhare, Matthew M Kavanagh
No abstract text is available yet for this article.
May 8, 2024: New England Journal of Medicine
#8
JOURNAL ARTICLE
Eric A Pierce, Tomas S Aleman, Kanishka T Jayasundera, Bright S Ashimatey, Keunpyo Kim, Alia Rashid, Michael C Jaskolka, Rene L Myers, Byron L Lam, Steven T Bailey, Jason I Comander, Andreas K Lauer, Albert M Maguire, Mark E Pennesi
BACKGROUND: CEP290 -associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290 . EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) gene-editing complex designed to treat inherited retinal degeneration caused by a specific damaging variant in intron 26 of CEP290 (IVS26 variant). METHODS: We performed a phase 1-2, open-label, single-ascending-dose study in which persons 3 years of age or older with CEP290 -associated inherited retinal degeneration caused by a homozygous or compound heterozygous IVS26 variant received a subretinal injection of EDIT-101 in the worse (study) eye...
May 6, 2024: New England Journal of Medicine
#9
JOURNAL ARTICLE
Lucy E Geraghty, Emma A Dunne, Caitríona M Ní Chathasaigh, Akke Vellinga, Niamh C Adams, Eoin M O'Currain, Lisa K McCarthy, Colm P F O'Donnell
BACKGROUND: Repeated attempts at endotracheal intubation are associated with increased adverse events in neonates. When clinicians view the airway directly with a laryngoscope, fewer than half of first attempts are successful. The use of a video laryngoscope, which has a camera at the tip of the blade that displays a view of the airway on a screen, has been associated with a greater percentage of successful intubations on the first attempt than the use of direct laryngoscopy in adults and children...
May 5, 2024: New England Journal of Medicine
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JOURNAL ARTICLE
Matiar Madanchi, Peter Itin
New England Journal of Medicine, Volume 390, Issue 18, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#11
JOURNAL ARTICLE
Tessa Adžemović
New England Journal of Medicine, Volume 390, Issue 18, Page 1645-1647, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#12
JOURNAL ARTICLE
Ahmad El-Hellani, Theodore L Wagener, Marielle C Brinkman
New England Journal of Medicine, Volume 390, Issue 18, Page 1639-1641, May 9, 2024.
May 4, 2024: New England Journal of Medicine
#13
LETTER
Timothy M Uyeki, Scott Milton, Cherissa Abdul Hamid, Cynthia Reinoso Webb, Steven M Presley, Varun Shetty, Susan N Rollo, Diana L Martinez, Saroj Rai, Emilio R Gonzales, Krista L Kniss, Yunho Jang, Julia C Frederick, Juan A De La Cruz, Jimma Liddell, Han Di, Marie K Kirby, John R Barnes, C Todd Davis
No abstract text is available yet for this article.
May 3, 2024: New England Journal of Medicine
#14
JOURNAL ARTICLE
Christoph Winkler
New England Journal of Medicine, Volume 390, Issue 17, May 2, 2024.
April 27, 2024: New England Journal of Medicine
#15
JOURNAL ARTICLE
Merlin Chowkwanyun
New England Journal of Medicine, Volume 390, Issue 17, Page 1541-1547, May 2, 2024.
April 27, 2024: New England Journal of Medicine
#16
EDITORIAL
Trevor Mundel
New England Journal of Medicine, Volume 390, Issue 17, Page 1620-1621, May 2, 2024.
April 26, 2024: New England Journal of Medicine
#17
JOURNAL ARTICLE
Kassoum Kayentao, Aissata Ongoiba, Anne C Preston, Sara A Healy, Zonghui Hu, Jeff Skinner, Safiatou Doumbo, Jing Wang, Hamidou Cisse, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary E Peterson, Shinyi Telscher, Azza H Idris, William C Adams, Adrian B McDermott, Sandeep Narpala, Bob C Lin, Leonid Serebryannyy, Somia P Hickman, Andrew J McDougal, Sandra Vazquez, Matthew Reiber, Judy A Stein, Jason G Gall, Kevin Carlton, Philipp Schwabl, Siriman Traore, Mamadou Keita, Amatigué Zéguimé, Adama Ouattara, M'Bouye Doucoure, Amagana Dolo, Sean C Murphy, Daniel E Neafsey, Silvia Portugal, Abdoulaye Djimdé, Boubacar Traore, Robert A Seder, Peter D Crompton
BACKGROUND: Subcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal antibody administered subcutaneously can protect children from P. falciparum infection in a region where this organism is endemic is unclear. METHODS: We conducted a phase 2 trial in Mali to assess the safety and efficacy of subcutaneous administration of L9LS in children 6 to 10 years of age over a 6-month malaria season...
April 26, 2024: New England Journal of Medicine
#18
JOURNAL ARTICLE
Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Mapara, Lyndsay Molinari, Donna Wall, Robert I Liem, Paul Telfer, Ami J Shah, Marina Cavazzana, Selim Corbacioglu, Damiano Rondelli, Roland Meisel, Laurence Dedeken, Stephan Lobitz, Mariane de Montalembert, Martin H Steinberg, Mark C Walters, Michael J Eckrich, Suzan Imren, Laura Bower, Christopher Simard, Weiyu Zhou, Fengjuan Xuan, Phuong Khanh Morrow, William E Hobbs, Stephan A Grupp
BACKGROUND: Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing of autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) at the erythroid-specific enhancer region of BCL11A . METHODS: We conducted a phase 3, single-group, open-label study of exa-cel in patients 12 to 35 years of age with sickle cell disease who had had at least two severe vaso-occlusive crises in each of the 2 years before screening...
April 24, 2024: New England Journal of Medicine
#19
JOURNAL ARTICLE
George Q Daley
New England Journal of Medicine, Volume 390, Issue 18, Page 1642-1645, May 9, 2024.
April 24, 2024: New England Journal of Medicine
#20
EDITORIAL
Joseph M McCune, Hans-Peter Kiem
New England Journal of Medicine, Volume 390, Issue 18, Page 1721-1722, May 9, 2024.
April 24, 2024: New England Journal of Medicine
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