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Malaria Journal

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https://www.readbyqxmd.com/read/28728595/malaria-after-international-travel-a-geosentinel-analysis-2003-2016
#1
Kristina M Angelo, Michael Libman, Eric Caumes, Davidson H Hamer, Kevin C Kain, Karin Leder, Martin P Grobusch, Stefan H Hagmann, Phyllis Kozarsky, David G Lalloo, Poh-Lian Lim, Calvin Patimeteeporn, Philippe Gautret, Silvia Odolini, François Chappuis, Douglas H Esposito
BACKGROUND: More than 30,000 malaria cases are reported annually among international travellers. Despite improvements in malaria control, malaria continues to threaten travellers due to inaccurate perception of risk and sub-optimal pre-travel preparation. METHODS: Records with a confirmed malaria diagnosis after travel from January 2003 to July 2016 were obtained from GeoSentinel, a global surveillance network of travel and tropical medicine providers that monitors travel-related morbidity...
July 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28728558/accuracy-of-a-plasmodium-falciparum-specific-histidine-rich-protein-2-rapid-diagnostic-test-in-the-context-of-the-presence-of-non-malaria-fevers-prior-anti-malarial-use-and-seasonal-malaria-transmission
#2
Francois Kiemde, Massa Dit Achille Bonko, Marc Christian Tahita, Palpouguini Lompo, Toussaint Rouamba, Halidou Tinto, Michael Boele van Hensbroek, Petra F Mens, Henk D F H Schallig
BACKGROUND: It remains challenging to distinguish malaria from other fever causing infections, as a positive rapid diagnostic test does not always signify a true active malaria infection. This study was designed to determine the influence of other causes of fever, prior anti-malarial treatment, and a possible seasonality of the performance of a PfHRP2 RDT for the diagnosis of malaria in children under-5 years of age living in a malaria endemic area. METHODS: A prospective etiology study was conducted in 2015 among febrile children under 5 years of age in Burkina Faso...
July 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28724446/economic-burden-of-malaria-inpatients-during-national-malaria-elimination-programme-estimation-of-hospitalization-cost-and-its-inter-province-variation
#3
Shangfeng Tang, Da Feng, Ruoxi Wang, Bishwajit Ghose, Tao Hu, Lu Ji, Tailai Wu, Hang Fu, Yueying Huang, Zhanchun Feng
BACKGROUND: Apart from its direct impact on public health and well-being, malaria had placed significant socioeconomic burden on both individuals and whole health systems. This study was conducted to investigate the hospitalization cost of malaria and explore the inter-province variation during the National Malaria Elimination Programme in China. METHODS: Information on medical expenditure for malaria treatment was extracted from inpatient medical records in Henan, Hainan and Guangxi Province...
July 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28724415/identification-and-characterization-of-the-antiplasmodial-activity-of-hsp90-inhibitors
#4
Claribel Murillo-Solano, Chunmin Dong, Cecilia G Sanchez, Juan C Pizarro
BACKGROUND: The recent reduction in mortality due to malaria is being threatened by the appearance of Plasmodium falciparum parasites that are resistant to artemisinin in Southeast Asia. To limit the impact of resistant parasites and their spread across the world, there is a need to validate anti-malarial drug targets and identify new leads that will serve as foundations for future drug development programmes targeting malaria. Towards that end, the antiplasmodial potential of several Hsp90 inhibitors was characterized...
July 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28720135/exploring-anti-malarial-potential-of-fda-approved-drugs-an-in-silico-approach
#5
Gayatri Ramakrishnan, Nagasuma Chandra, Narayanaswamy Srinivasan
BACKGROUND: The critically important issue on emergence of drug-resistant malarial parasites is compounded by cross resistance, where resistance to one drug confers resistance to other chemically similar drugs or those that share mode of action. This aspect requires discovery of new anti-malarial compounds or formulation of new combination therapy. The current study attempts to contribute towards accelerating anti-malarial drug development efforts, by exploring the potential of existing FDA-approved drugs to target proteins of Plasmodium falciparum...
July 18, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28720100/effect-of-seasonal-malaria-chemoprevention-on-the-acquisition-of-antibodies-to-plasmodium-falciparum-antigens-in-ouelessebougou-mali
#6
Almahamoudou Mahamar, Djibrilla Issiaka, Amadou Barry, Oumar Attaher, Adama B Dembele, Tiangoua Traore, Adama Sissoko, Sekouba Keita, Bacary Soumana Diarra, David L Narum, Patrick E Duffy, Alassane Dicko, Michal Fried
BACKGROUND: Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not clear if there is a cumulative effect of SMC over time on acquisition of antibodies to malaria antigens. METHODS: A cross-sectional serosurvey was carried out 1 month after the last dose of SMC in 2016...
July 18, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28716094/an-analytical-approach-to-reduce-between-plate-variation-in-multiplex-assays-that-measure-antibodies-to-plasmodium-falciparum-antigens
#7
Rui Fang, Andrew Wey, Naveen K Bobbili, Rose F G Leke, Diane Wallace Taylor, John J Chen
BACKGROUND: Antibodies play an important role in immunity to malaria. Recent studies show that antibodies to multiple antigens, as well as, the overall breadth of the response are associated with protection from malaria. Yet, the variability and reliability of antibody measurements against a combination of malarial antigens using multiplex assays have not been well characterized. METHODS: A normalization procedure for reducing between-plate variation using replicates of pooled positive and negative controls was investigated...
July 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28716087/explaining-variation-in-adult-anopheles-indoor-resting-abundance-the-relative-effects-of-larval-habitat-proximity-and-insecticide-treated-bed-net-use
#8
Robert S McCann, Joseph P Messina, David W MacFarlane, M Nabie Bayoh, John E Gimnig, Emanuele Giorgi, Edward D Walker
BACKGROUND: Spatial determinants of malaria risk within communities are associated with heterogeneity of exposure to vector mosquitoes. The abundance of adult malaria vectors inside people's houses, where most transmission takes place, should be associated with several factors: proximity of houses to larval habitats, structural characteristics of houses, indoor use of vector control tools containing insecticides, and human behavioural and environmental factors in and near houses. While most previous studies have assessed the association of larval habitat proximity in landscapes with relatively low densities of larval habitats, in this study these relationships were analysed in a region of rural, lowland western Kenya with high larval habitat density...
July 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28705249/vector-control-with-driving-y-chromosomes-modelling-the-evolution-of-resistance
#9
Andrea Beaghton, Pantelis John Beaghton, Austin Burt
BACKGROUND: The introduction of new malaria control interventions has often led to the evolution of resistance, both of the parasite to new drugs and of the mosquito vector to new insecticides, compromising the efficacy of the interventions. Recent progress in molecular and population biology raises the possibility of new genetic-based interventions, and the potential for resistance to evolve against these should be considered. Here, population modelling is used to determine the main factors affecting the likelihood that resistance will evolve against a synthetic, nuclease-based driving Y chromosome that produces a male-biased sex ratio...
July 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28705241/demand-and-willingness-to-pay-for-bed-nets-in-tanzania-results-from-a-choice-experiment
#10
Chris D Gingrich, Emily Ricotta, Amos Kahwa, Catherine Kahabuka, Hannah Koenker
BACKGROUND: Universal coverage campaigns for long-lasting insecticide-treated nets do not always reach the goal of one net for every two household members, and even when ownership of at least one net per household is high, many households may not own enough nets. The retail market provides these households options for replacing or increasing the number of nets they own with products that best fit their needs since a variety of net shapes, sizes, and colours are available. Hence, it is important to understand the factors affecting private net demand...
July 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28705160/tracking-development-assistance-and-government-health-expenditures-for-35-malaria-eliminating-countries-1990-2017
#11
Rima Shretta, Brittany Zelman, Maxwell L Birger, Annie Haakenstad, Lavanya Singh, Yingying Liu, Joseph Dieleman
BACKGROUND: Donor financing for malaria has declined since 2010 and this trend is projected to continue for the foreseeable future. These reductions have a significant impact on lower burden countries actively pursuing elimination, which are usually a lesser priority for donors. While domestic spending on malaria has been growing, it varies substantially in speed and magnitude across countries. A clear understanding of spending patterns and trends in donor and domestic financing is needed to uncover critical investment gaps and opportunities...
July 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693608/temporal-analysis-of-igg-antibody-responses-to-plasmodium-falciparum-antigens-in-relation-to-changing-malaria-epidemiology-in-a-west-african-setting
#12
Makhtar Niang, Oumy Niass, Nafissatou Diagne, Fatoumata Diene Sarr, Michel Matar Faye, Fode Diop, Babacar Diouf, Joseph Faye, Abdoulaye Badiane, Ronald Perraut, Cheikh Sokhna, Jean-François Trape, Adama Tall, Aissatou Toure-Balde
BACKGROUND: Coordinated scaled-up malaria control interventions have substantially contributed to the dramatic decrease of malaria-related morbidity and mortality in several endemic countries, including Senegal. However, the impacts of a given malaria control intervention on vector and parasite populations, acquired immunity, and disease burden remain very poorly documented largely due to the lack of continuous surveys. This study took advantage of the sera bank established as part of the Dielmo longitudinal project to investigate the dynamics of IgG antibody responses that accompanied the epidemiological changes resulting from malaria control interventions...
July 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693607/dynamics-of-plasmodium-vivax-sporogony-in-wild-anopheles-stephensi-in-a-malaria-endemic-region-of-western-india
#13
Praveen Balabaskaran Nina, Ajeet Kumar Mohanty, Shuvankar Ballav, Smita Vernekar, Sushma Bhinge, Maria D'souza, Jayashree Walke, Suresh Kumar Manoharan, Anjali Mascarenhas, Edwin Gomes, Laura Chery, Neena Valecha, Ashwani Kumar, Pradipsinh K Rathod
BACKGROUND: In global efforts to track mosquito infectivity and parasite elimination, controlled mosquito-feeding experiments can help in understanding the dynamics of parasite development in vectors. Anopheles stephensi is often accepted as the major urban malaria vector that transmits Plasmodium in Goa and elsewhere in South Asia. However, much needs to be learned about the interactions of Plasmodium vivax with An. stephensi. As a component of the US NIH International Center of Excellence for Malaria Research (ICEMR) for Malaria Evolution in South Asia (MESA), a series of membrane-feeding experiments with wild An...
July 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693488/donor-support-for-quality-assurance-and-pharmacovigilance-of-anti-malarials-in-malaria-endemic-countries
#14
Stephanie D Kovacs, Brianna M Mills, Andy Stergachis
BACKGROUND: Malaria control efforts have been strengthened by funding from donor groups and government agencies. The Global Fund to Fight AIDS, Tuberculosis and the Malaria (Global Fund), the US President's Malaria Initiative (PMI) account for the majority of donor support for malaria control and prevention efforts. Pharmacovigilance (PV), which encompasses all activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problem, is a necessary part of efforts to reduce drug resistance and improve treatment outcomes...
July 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28693552/chloroquine-efficacy-for-plasmodium-vivax-in-myanmar-in-populations-with-high-genetic-diversity-and-moderate-parasite-gene-flow
#15
Myo Win Htun, Nan Cho Nwe Mon, Khin Myo Aye, Chan Myae Hlaing, Myat Phone Kyaw, Irene Handayuni, Hidayat Trimarsanto, Dorina Bustos, Pascal Ringwald, Ric N Price, Sarah Auburn, Kamala Thriemer
BACKGROUND: Plasmodium vivax malaria remains a major public health burden in Myanmar. Resistance to chloroquine (CQ), the first-line treatment for P. vivax, has been reported in the country and has potential to undermine local control efforts. METHODS: Patients over 6 years of age with uncomplicated P. vivax mono-infection were enrolled into clinical efficacy studies in Myawaddy in 2014 and Kawthoung in 2012. Study participants received a standard dose of CQ (25 mg/kg over 3 days) followed by weekly review until day 28...
July 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28687086/ivermectin-susceptibility-and-sporontocidal-effect-in-greater-mekong-subregion-anopheles
#16
Kevin C Kobylinski, Ratawan Ubalee, Alongkot Ponlawat, Chanyapat Nitatsukprasert, Siriporn Phasomkulsolsil, Thanaporn Wattanakul, Joel Tarning, Kesara Na-Bangchang, Patrick W McCardle, Silas A Davidson, Jason H Richardson
BACKGROUND: Novel vector control methods that can directly target outdoor malaria transmission are urgently needed in the Greater Mekong Subregion (GMS) to accelerate malaria elimination and artemisinin resistance containment efforts. Ivermectin mass drug administration (MDA) to humans has been shown to effectively kill wild Anopheles and suppress malaria transmission in West Africa. Preliminary laboratory investigations were performed to determine ivermectin susceptibility and sporontocidal effect in GMS Anopheles malaria vectors coupled with pharmacokinetic models of ivermectin at escalating doses...
July 7, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28679447/in-vitro-inhibition-and-reversal-of-plasmodium-falciparum-cytoadherence-to-endothelium-by-monoclonal-antibodies-to-icam-1-and-cd36
#17
Khairul M F Mustaffa, Janet Storm, Megan Whittaker, Tadge Szestak, Alister G Craig
BACKGROUND: Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells, known as cytoadherence. Several lines of evidence point to a link between the pathology of severe malaria and cytoadherence, therefore blocking adhesion receptors involved in this process could be a good target to inhibit pRBC sequestration and prevent disease...
July 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28679421/health-information-system-strengthening-and-malaria-elimination-in-papua-new-guinea
#18
Alexander Rosewell, Leo Makita, David Muscatello, Lucy Ninmongo John, Sibauk Bieb, Ross Hutton, Sundar Ramamurthy, Phil Shearman
BACKGROUND: The objective of the study was to describe an m-health initiative to strengthen malaria surveillance in a 184-health facility, multi-province, project aimed at strengthening the National Health Information System (NHIS) in a country with fragmented malaria surveillance, striving towards enhanced control, pre-elimination. METHODS: A remote-loading mobile application and secure online platform for health professionals was created to interface with the new system (eNHIS)...
July 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28679378/cost-effectiveness-analysis-of-the-national-implementation-of-integrated-community-case-management-and-community-based-health-planning-and-services-in-ghana-for-the-treatment-of-malaria-diarrhoea-and-pneumonia
#19
Blanca Escribano Ferrer, Kristian Schultz Hansen, Margaret Gyapong, Jane Bruce, Solomon A Narh Bana, Clement T Narh, Naa-Korkor Allotey, Roland Glover, Naa-Charity Azantilow, Constance Bart-Plange, Isabella Sagoe-Moses, Jayne Webster
BACKGROUND: Ghana has developed two main community-based strategies that aim to increase access to quality treatment for malaria, diarrhoea and suspected pneumonia: the integrated community case management (iCCM) and the community-based health planning and services (CHPS). The aim of the study was to assess the cost-effectiveness of these strategies under programme conditions. METHODS: A cost-effectiveness analysis was conducted. Appropriate diagnosis and treatment given was the effectiveness measure used...
July 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28676093/the-invasive-shrub-prosopis-juliflora-enhances-the-malaria-parasite-transmission-capacity-of-anopheles-mosquitoes-a-habitat-manipulation-experiment
#20
Gunter C Muller, Amy Junnila, Mohamad M Traore, Sekou F Traore, Seydou Doumbia, Fatoumata Sissoko, Seydou M Dembele, Yosef Schlein, Kristopher L Arheart, Edita E Revay, Vasiliy D Kravchenko, Arne Witt, John C Beier
BACKGROUND: A neglected aspect of alien invasive plant species is their influence on mosquito vector ecology and malaria transmission. Invasive plants that are highly attractive to Anopheles mosquitoes provide them with sugar that is critical to their survival. The effect on Anopheles mosquito populations was examined through a habitat manipulation experiment that removed the flowering branches of highly attractive Prosopis juliflora from selected villages in Mali, West Africa. METHODS: Nine villages in the Bandiagara district of Mali were selected, six with flowering Prosopis juliflora, and three without...
July 5, 2017: Malaria Journal
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