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Malaria Journal

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https://www.readbyqxmd.com/read/29329545/use-of-epidemiological-and-entomological-tools-in-the-control-and-elimination-of-malaria-in-ethiopia
#1
REVIEW
Abebe Animut, Bernt Lindtjørn
Malaria is the leading public health problem in Ethiopia where over 75% of the land surface is at risk with varying intensities depending on altitude and season. Although the mortality because of malaria infection has declined much during the last 15-20 years, some researchers worry that this success story may not be sustainable. Past notable achievements in the reduction of malaria disease burden could be reversed in the future. To interrupt, or even to eliminate malaria transmission in Ethiopia, there is a need to implement a wide range of interventions that include insecticide-treated bed nets, indoor residual spraying, improved control of residual malaria transmission, and improved diagnostics, enhanced surveillance, and methods to deal with the emergence of resistance both to drugs and to insecticides...
January 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29329539/state-dependent-domicile-leaving-rates-in-anopheles-gambiae
#2
Simon P W Zappia, Alex M Chubaty, Bernard D Roitberg
BACKGROUND: Transmission of Plasmodium greatly depends on the foraging behaviour of its mosquito vector (Anopheles spp.). The accessibility of blood hosts and availability of plant sugar (i.e., nectar) sources, together with mosquito energy state, have been shown to modulate blood feeding (and thus biting rates) of anopheline mosquitoes. In this study, the influence of mosquito starvation status and availability of nectar on the decision of female Anopheles gambiae mosquitoes to leave a bed net-protected blood host was examined...
January 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29325573/genetic-diversity-of-three-surface-protein-genes-in-plasmodium-malariae-from-three-asian-countries
#3
Suttipat Srisutham, Naowarat Saralamba, Kanlaya Sriprawat, Mayfong Mayxay, Frank Smithuis, Francois Nosten, Sasithon Pukrittayakamee, Nicholas P J Day, Arjen M Dondorp, Mallika Imwong
BACKGROUND: Genetic diversity of the three important antigenic proteins, namely thrombospondin-related anonymous protein (TRAP), apical membrane antigen 1 (AMA1), and 6-cysteine protein (P48/45), all of which are found in various developmental stages of Plasmodium parasites is crucial for targeted vaccine development. While studies related to the genetic diversity of these proteins are available for Plasmodium falciparum and Plasmodium vivax, barely enough information exists regarding Plasmodium malariae...
January 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29321025/diagnostic-challenges-of-prolonged-post-treatment-clearance-of-plasmodium-nucleic-acids-in-a-pre-transplant-autosplenectomized-patient-with-sickle-cell-disease
#4
Paul M Luethy, Sean C Murphy, Annette M Seilie, Yingda L Xie, Chuen-Yen Lau, John F Tisdale, Matthew M Hsieh, Jessica L Reinhardt, Anna F Lau, Gary A Fahle
BACKGROUND: Autosplenectomy, as a result of sickle cell disease, is an important risk factor for severe malaria. While molecular methods are helpful in providing rapid and accurate infection detection and species identification, the effect of hyposplenism on result interpretation during the course of infection should be carefully considered. CASE PRESENTATION: A 32-year old autosplenectomized Nigerian male with severe sickle cell disease was referred to the National Institutes of Health for allogenic hematopoietic stem cell transplant...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29321011/attractive-toxic-sugar-baits-for-controlling-mosquitoes-a-qualitative-study-in-bagamoyo-tanzania
#5
Marta Ferreira Maia, Frank Chelestino Tenywa, Hannah Nelson, Athumani Kambagha, Abigail Ashura, Ibrahim Bakari, Deogratis Mruah, Aziza Simba, Ally Bedford
BACKGROUND: Malaria elimination is unlikely to be achieved without the implementation of new vector control interventions capable of complementing insecticide-treated nets and indoor residual spraying. Attractive-toxic sugar baits (ATSBs) are considered a new vector control paradigm. They are technologically appropriate as they are simple and affordable to produce. ATSBs kill both female and male mosquitoes attracted to sugar feed on a sugary solution containing a mosquitocidal agent and may be used indoors or outdoors...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316918/in-silico-epitope-mapping-and-experimental-evaluation-of-the-merozoite-adhesive-erythrocytic-binding-protein-maebl-as-a-malaria-vaccine-candidate
#6
Pedro Cravo, Renato B Machado, Juliana A Leite, Taizy Leda, Rossarin Suwanarusk, Najara Bittencourt, Letusa Albrecht, Carla Judice, Stefanie C P Lopes, Marcus V G Lacerda, Marcelo U Ferreira, Irene S Soares, Yun Shan Goh, Daniel Y Bargieri, François Nosten, Bruce Russell, Laurent Rénia, Fabio T M Costa
BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping of MAEBL through immunoinformatics identified several MHCI, MHCII and B cell epitopes throughout the peptide, with several of these lying in the M2 domain and being conserved between P...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316917/an-observational-analysis-of-the-impact-of-indoor-residual-spraying-with-non-pyrethroid-insecticides-on-the-incidence-of-malaria-in-s%C3%A3-gou-region-mali-2012-2015
#7
Joseph Wagman, Christelle Gogue, Kenzie Tynuv, Jules Mihigo, Elie Bankineza, Mamadou Bah, Diadier Diallo, Andrew Saibu, Jason H Richardson, Diakalkia Kone, Seydou Fomba, Jeff Bernson, Richard Steketee, Laurence Slutsker, Molly Robertson
BACKGROUND: Ségou Region in Central Mali is an area of high malaria burden with seasonal transmission, high access to and use of long-lasting insecticidal nets (LLINs), and resistance to pyrethroids and DDT well documented in Anopheles gambiae s.l. (the principal vector of malaria in Mali). Ségou has recently received indoor residual spraying (IRS) supported by Mali's collaboration with the US President's Malaria Initiative/Africa Indoor Residual Spraying programme. From 2012 to 2015, two different non-pyrethroid insecticides: bendiocarb in 2012 and 2013 and pirimiphos-methyl in 2014 and 2015, were used for IRS in two districts...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316916/malaria-programme-personnel-s-experiences-perceived-barriers-and-facilitators-to-implementing-malaria-elimination-strategy-in-south-africa
#8
Khumbulani Welcome Hlongwana, Benn Sartorius, Joyce Tsoka-Gwegweni
BACKGROUND: South Africa has set an ambitious goal targeting to eliminate malaria by 2018, which is consistent with the United Nations Sustainable Development Goals' call to end the epidemic of malaria by 2030 across the globe. There are conflicting views regarding the feasibility of malaria elimination, and furthermore studies investigating malaria programme personnel's perspectives on strategy implementation are lacking. METHODS: The study was a cross-sectional survey conducted in 2014 through a face-to-face investigator-administered semi-structured questionnaire to all eligible and consenting malaria programme personnel (team leader to senior manager levels) in three malaria endemic provinces (KwaZulu-Natal, Mpumalanga, and Limpopo) of South Africa...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316932/why-do-people-participate-in-mass-anti-malarial-administration-findings-from-a-qualitative-study-in-nong-district-savannakhet-province-lao-pdr-laos
#9
Bipin Adhikari, Koukeo Phommasone, Palingnaphone Kommarasy, Xayaphone Soundala, Phonesavanh Souvanthong, Tiengkham Pongvongsa, Gisela Henriques, Paul N Newton, Nicholas J White, Nicholas P J Day, Arjen M Dondorp, Lorenz von Seidlein, Mayfong Mayxay, Phaik Yeong Cheah, Christopher Pell
BACKGROUND: As a part of targeted malaria elimination (TME) in the Greater Mekong Sub-region (GMS), mass drug administration (MDA) with anti-malarials was conducted in four villages in Nong District, Savannakhet Province, Lao PDR (Laos). A high proportion of the target population participated in the MDA, with over 87% agreeing to take the anti-malarial. Drawing on qualitative data collected alongside the MDA, this article explores the factors that led to this high population coverage...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316929/molecular-identification-of-sulfadoxine-pyrimethamine-resistance-in-malaria-infected-women-who-received-intermittent-preventive-treatment-in-the-democratic-republic-of-congo
#10
Emrah Ruh, Jean Paul Bateko, Turgut Imir, Aysegul Taylan-Ozkan
BACKGROUND: Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes which confer resistance to sulfadoxine-pyrimethamine (SP) occur at increasing rates. The present study aimed to identify Pfdhfr and Pfdhps mutations in P. falciparum isolates recovered from women who received two doses of SP during pregnancy in Bandundu, the Democratic Republic of Congo (DRC). METHODS: A total of 48 women with confirmed P...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316927/global-sequence-diversity-of-the-lactate-dehydrogenase-gene-in-plasmodium-falciparum
#11
Phumin Simpalipan, Sittiporn Pattaradilokrat, Pongchai Harnyuttanakorn
BACKGROUND: Antigen-detecting rapid diagnostic tests (RDTs) have been recommended by the World Health Organization for use in remote areas to improve malaria case management. Lactate dehydrogenase (LDH) of Plasmodium falciparum is one of the main parasite antigens employed by various commercial RDTs. It has been hypothesized that the poor detection of LDH-based RDTs is attributed in part to the sequence diversity of the gene. To test this, the present study aimed to investigate the genetic diversity of the P...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316914/differential-induction-of-malaria-liver-pathology-in-mice-infected-with-plasmodium-chabaudi-as-or-plasmodium-berghei-nk65
#12
Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E Van den Steen, Donatella Taramelli
BACKGROUND: Cerebral malaria and severe anaemia are the most common deadly complications of malaria, and are often associated, both in paediatric and adult patients, with hepatopathy, whose pathogenesis is not well characterized, and sometimes also with acute respiratory distress syndrome (ARDS). Here, two species of murine malaria, the lethal Plasmodium berghei strain NK65 and self-healing Plasmodium chabaudi strain AS which differ in their ability to cause hepatopathy and/or ARDS were used to investigate the lipid alterations, oxidative damage and host immune response during the infection in relation to parasite load and accumulation of parasite products, such as haemozoin...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310662/assessment-of-the-quality-and-quantity-of-naturally-induced-antibody-responses-to-eba175riii-v-in-ghanaian-children-living-in-two-communities-with-varying-malaria-transmission-patterns
#13
Hamza B Abagna, Festus K Acquah, Ruth Okonu, Nii A Aryee, Michael Theisen, Linda E Amoah
BACKGROUND: Recent global reports on malaria suggest significant decrease in disease severity and an increase in control interventions in many malaria endemic countries, including Ghana. However, a major driving force sustaining malaria transmission in recent times is the asymptomatic carriage of malaria parasites, which can enhance immune responses against parasite antigens. This study determined the prevalence and relative avidities of naturally induced antibodies to EBA175RIII-VLl in asymptomatic children living in two communities with varying malaria transmission patterns...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310656/comparative-evaluation-of-anopheline-sampling-methods-in-three-localities-in-indonesia
#14
Brandyce St Laurent, Supratman Sukowati, Timothy A Burton, David Bretz, Mulyadi Zio, Syah Firman, Sumardi, Heru Sudibyo, Amalia Safitri, Suwito, Puji B Asih, Sully Kosasih, Shinta, William A Hawley, Thomas R Burkot, Frank H Collins, Din Syafruddin, Neil F Lobo
BACKGROUND: The effectiveness of vector control efforts can vary based on the interventions used and local mosquito behaviour and adaptability. In many settings, biting patterns of Anopheles mosquitoes can shift in response to interventions targeting indoor-biting mosquitoes, often resulting in higher proportions of mosquitoes feeding outside or at times when people are not protected. These behaviourally resistant mosquitoes have been shown to sustain residual malaria transmission and limit control efforts...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310655/methylene-blue-induced-morphological-deformations-in-plasmodium-falciparum-gametocytes-implications-for-transmission-blocking
#15
Ishan Wadi, C Radhakrishna Pillai, Anupkumar R Anvikar, Abhinav Sinha, Mahendra Nath, Neena Valecha
BACKGROUND: Malaria remains a global health problem despite availability of effective tools. For malaria elimination, drugs targeting sexual stages of Plasmodium falciparum need to be incorporated in treatment regimen along with schizonticidal drugs to interrupt transmission. Primaquine is recommended as a transmission blocking drug for its effect on mature gametocytes but is not extensively utilized because of associated safety concerns among glucose-6-phosphate dehydrogenase (G6PD) deficient patients...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310651/stabilization-of-rdt-target-antigens-present-in-dried-plasmodium-falciparum-infected-samples-for-validating-malaria-rapid-diagnostic-tests-at-the-point-of-care
#16
Collins Morang'a, Cyrus Ayieko, George Awinda, Rachel Achilla, Caroline Moseti, Bernhards Ogutu, John Waitumbi, Elizabeth Wanja
BACKGROUND: Malaria rapid diagnostic tests (RDTs) are a great achievement in implementation of parasite based diagnosis as recommended by World Health Organization. A major drawback of RDTs is lack of positive controls to validate different batches/lots at the point of care. Dried Plasmodium falciparum-infected samples with the RDT target antigens have been suggested as possible positive control but their utility in resource limited settings is hampered by rapid loss of activity over time...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29310650/parasitaemia-data-and-molecular-characterization-of-haemoproteus-catharti-from-new-world-vultures-cathartidae-reveals-a-novel-clade-of-haemosporida
#17
Michael J Yabsley, Ralph E T Vanstreels, Ellen S Martinsen, Alexandra G Wickson, Amanda E Holland, Sonia M Hernandez, Alec T Thompson, Susan L Perkins, Christopher J West, A Lawrence Bryan, Christopher A Cleveland, Emily Jolly, Justin D Brown, Dave McRuer, Shannon Behmke, James C Beasley
BACKGROUND: New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in morphology, physiology, and behaviour. Three species of haemosporidians have been reported in New World vultures to date: Haemoproteus catharti, Leucocytozoon toddi and Plasmodium elongatum, although few studies have investigated haemosporidian parasites in this important group of species...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304859/a-phase-1-evaluation-of-the-pharmacokinetic-pharmacodynamic-interaction-of-the-anti-malarial-agents-kaf156-and-piperaquine
#18
F Joel Leong, Jay Prakash Jain, Yiyan Feng, Budhaditya Goswami, Daniel S Stein
BACKGROUND: KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for KAF156 use in combination with piperaquine (PPQ) as both drugs are CYP3A4 substrates and inhibitors. Potential combination effects on the QT interval were also assessed. METHODS: This was an open-label, parallel-group, single-dose study in healthy volunteers randomized to three parallel arms (1:1:1) of 800 mg KAF156 + 1280 mg PPQ, 800 mg KAF156 alone and 1280 mg PPQ alone...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304809/estimation-on-local-transmission-of-malaria-by-serological-approach-under-low-transmission-setting-in-myanmar
#19
Myat Htut Nyunt, Than Naing Soe, Thinzar Shein, Ni Ni Zaw, Soe Soe Han, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Ji-Hoon Park, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Myat Phone Kyaw, Eun-Taek Han
BACKGROUND: As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be established in this setting. METHODS: One-year cohort study was conducted and sera samples were collected in every 3 months with active and passive case detection for clinical malaria episodes by RDT, microscopy and molecular method...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304805/status-of-insecticide-resistance-in-malaria-vectors-in-kwale-county-coastal-kenya
#20
Caroline W Kiuru, Florence Awino Oyieke, Wolfgang Richard Mukabana, Joseph Mwangangi, Luna Kamau, Damaris Muhia-Matoke
BACKGROUND: The strategy for malaria vector control in the context of reducing malaria morbidity and mortality has been the scale-up of long-lasting insecticidal nets to universal coverage and indoor residual spraying. This has led to significant decline in malaria transmission. However, these vector control strategies rely on insecticides which are threatened by insecticide resistance. In this study the status of pyrethroid resistance in malaria vectors and it's implication in malaria transmission at the Kenyan Coast was investigated...
January 5, 2018: Malaria Journal
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