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Malaria Journal

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https://www.readbyqxmd.com/read/30445967/severe-plasmodium-vivax-malaria-hiv-tuberculosis-co-infection-in-a-sri-lankan-traveller-case-management-and-challenges-during-the-prevention-of-malaria-reintroduction-phase
#1
Dewanee Ranaweera, R M J Kanchana Rajapaksha, Priyanganie Silva, Raja Hettiarachchi, W M Kumudu T de A W Gunasekera, Hemantha Herath, Deepika Fernando
BACKGROUND: The country received malaria-free certification from WHO in September 2016, becoming only the second country in the WHO South East Asia region to be declared malaria-free. Imported malaria cases continue to be reported, with 278 cases reported between 2013 and 2017. The diagnosis of a severe Plasmodium vivax patient co-infected with HIV and tuberculosis is discussed with an overview of the rapid response mounted by the Anti Malaria Campaign (AMC), Sri Lanka. CASE PRESENTATION: A Sri Lankan gem miner who returned from Madagascar on the 6th of April 2018 presented to a private hospital for a malaria diagnostic test on the 21st April, 2 days after the onset of fever...
November 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30445962/bayesian-spatiotemporal-analysis-of-malaria-infection-along-an-international-border-hlaingbwe-township-in-myanmar-and-tha-song-yang-district-in-thailand
#2
Aung Minn Thway, Chawarat Rotejanaprasert, Jetsumon Sattabongkot, Siam Lawawirojwong, Aung Thi, Tin Maung Hlaing, Thiha Myint Soe, Jaranit Kaewkungwal
BACKGROUND: One challenge in moving towards malaria elimination is cross-border malaria infection. The implemented measures to prevent and control malaria re-introduction across the demarcation line between two countries require intensive analyses and interpretation of data from both sides, particularly in border areas, to make correct and timely decisions. Reliable maps of projected malaria distribution can help to direct intervention strategies. In this study, a Bayesian spatiotemporal analytic model was proposed for analysing and generating aggregated malaria risk maps based on the exceedance probability of malaria infection in the township-district adjacent to the border between Myanmar and Thailand...
November 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30445959/inter-sectoral-approaches-for-the-prevention-and-control-of-malaria-among-the-mobile-and-migrant-populations-a-scoping-review
#3
Cho Naing, Maxine A Whittaker, Marcel Tanner
BACKGROUND: Malaria cases among mobile and migrant populations (MMPs) represent a large and important reservoir for transmission, if undetected or untreated. The objectives of this review were to identify which intersectoral actions have been taken and how they are applied to interventions targeted at the MMPs and also to assess the effect of interventions targeted to these special groups of population. RESULTS: A total of 36 studies met the inclusion criteria for this review...
November 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30442143/real-time-pcr-detection-of-common-cyp2d6-genetic-variants-and-its-application-in-a-karen-population-study
#4
Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P J Day, Francois Nosten, Nicholas J White, Arjen M Dondorp, Mallika Imwong
BACKGROUND: Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prodrug, requires metabolism through the liver cytochrome CYP2D6 isoenzyme to its active metabolite. Mutations in the CYP2D6 gene may thus affect primaquine efficacy. A SNPs genotyping technique was developed to characterize the CYP2D6 genetic variants and tested this in the patients with Plasmodium vivax infection collected in a Karen population on the Thailand-Myanmar border, where P...
November 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30442134/levels-of-human-proteins-in-plasma-associated-with-acute-paediatric-malaria
#5
Philippa Reuterswärd, Sofia Bergström, Judy Orikiiriza, Elisabeth Lindquist, Sven Bergström, Helene Andersson Svahn, Burcu Ayoglu, Mathias Uhlén, Mats Wahlgren, Johan Normark, Ulf Ribacke, Peter Nilsson
BACKGROUND: The intimate interaction between the pathophysiology of the human host and the biology of the Plasmodium falciparum parasite results in a wide spectrum of disease outcomes in malaria. Development of severe disease is associated with a progressively augmented imbalance in pro- and anti-inflammatory responses to high parasite loads and sequestration of parasitized erythrocytes. Although these phenomena collectively constitute common denominators for the wide variety of discrete severe malaria manifestations, the mechanistic rationales behind discrepancies in outcome are poorly understood...
November 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30442132/fear-and-rumours-regarding-placental-biopsies-in-a-malaria-in-pregnancy-trial-in-benin
#6
Adélaïde Compaoré, Susan Dierickx, Fatou Jaiteh, Alain Nahum, Towanou Francis Emmanuel Bohissou, Halidou Tinto, Susana Scott, Umberto D'Alessandro, Henk Schallig, Koen Peeters Grietens
BACKGROUND: A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study became subject to rumours and accusations of placenta being sold for mystical and financial gain by trial staff, leading to drop-out rates of 30% and the consequent halting of placental biopsy sampling in Benin. This paper explores the role of socio-cultural beliefs related to placenta and identified additional factors contributing these rumours...
November 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30428916/age-and-gender-trends-in-insecticide-treated-net-use-in-sub-saharan-africa-a-multi-country-analysis
#7
Bolanle Olapeju, Ifta Choiriyyah, Matthew Lynch, Angela Acosta, Sean Blaufuss, Eric Filemyr, Hunter Harig, April Monroe, Richmond Ato Selby, Albert Kilian, Hannah Koenker
BACKGROUND: The degree to which insecticide-treated net (ITN) supply accounts for age and gender disparities in ITN use among household members is unknown. This study explores the role of household ITN supply in the variation in ITN use among household members in sub-Saharan Africa. METHODS: Data was from Malaria Indicator Surveys or Demographic and Health Surveys collected between 2011 and 2016 from 29 countries in sub-Saharan Africa. The main outcome was ITN use the previous night...
November 14, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30428880/impact-evaluation-of-malaria-control-interventions-on-morbidity-and-all-cause-child-mortality-in-mali-2000-2012
#8
Kassoum Kayentao, Lia S Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo, Erin Eckert
BACKGROUND: Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and children under 5 years old, the introduction of artemisinin combination therapy (ACT) for malaria treatment, and indoor residual spraying of insecticides. Funders include the Government of Mali, the Global Fund to Fight AIDS, Tuberculosis and Malaria, and the US President's Malaria Initiative...
November 14, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30424788/resistancesim-development-and-acceptability-study-of-a-serious-game-to-improve-understanding-of-insecticide-resistance-management-in-vector-control-programmes
#9
Edward K Thomsen, Charlotte Hemingway, Andy South, Kirsten A Duda, Claire Dormann, Robert Farmer, Michael Coleman, Marlize Coleman
The use of insecticides is the cornerstone of effective malaria vector control. However, the last two decades has seen the ubiquitous use of insecticides, predominantly pyrethroids, causing widespread insecticide resistance and compromising the effectiveness of vector control. Considerable efforts to develop new active ingredients and interventions are underway. However, it is essential to deploy strategies to mitigate the impact of insecticide resistance now, both to maintain the efficacy of currently available tools as well as to ensure the sustainability of new tools as they come to market...
November 13, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30424775/llin-evaluation-in-uganda-project-llineup-factors-associated-with-ownership-and-use-of-long-lasting-insecticidal-nets-in-uganda-a-cross-sectional-survey-of-48-districts
#10
Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Sheila Rugnao, Grant Dorsey, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Amy Lynd, Janet Hemingway, Martin Donnelly, Moses R Kamya, Sarah G Staedke
BACKGROUND: Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in March-June 2017, approximately 3 years after a national Universal Coverage Campaign (UCC). METHODS: Households from 104 clusters (health sub-districts) in 48 districts were randomly selected using two-staged cluster sampling; 50 households were enrolled per cluster...
November 13, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30419923/correlation-of-malaria-parasitaemia-with-peripheral-blood-monocyte-to-lymphocyte-ratio-as-indicator-of-susceptibility-to-severe-malaria-in-ghanaian-children
#11
Samuel Antwi-Baffour, Ransford Kyeremeh, Dorcas Buabeng, Jonathan Kofi Adjei, Claudia Aryeh, George Kpentey, Mahmood Abdulai Seidu
BACKGROUND: Even though malaria is generally on the decline due extensive control and elimination efforts, it still remains a public health problem for over 40% of the world's population. During the course of malaria infection, parasites and red blood cells come under oxidative stress and there is host immune response in an attempt to protect the red blood cells. The frequency of monocytes and lymphocytes in peripheral blood might, therefore, be expected to reflect the state of an individual's immune response to the infection...
November 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30419917/spatial-temporal-distribution-of-anopheles-larval-habitats-in-uganda-using-gis-remote-sensing-technologies
#12
Ryan Tokarz, Robert J Novak
BACKGROUND: Anopheles mosquitoes impose an immense burden on the African population in terms of both human health and comfort. Uganda, in particular, boasts one of the highest malaria transmission rates in the world and its entire population is at risk for infection. Despite the immense burden these mosquitoes pose on the country, very few programmes exist that directly combat the issue at the vector control level and even fewer programmes focus on the vector in its most vulnerable juvenile stages...
November 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30419901/malaria-epidemiology-in-suriname-from-2000-to-2016-trends-opportunities-and-challenges-for-elimination
#13
Hélène Hiwat, Beatriz Martínez-López, Hedley Cairo, Loretta Hardjopawiro, Agatha Boerleider, Elisabeth Carmen Duarte, Zaida E Yadon
BACKGROUND: Suriname has experienced a significant change in malaria transmission risk and incidence over the past years. The country is now moving toward malaria elimination. The first objective of this study is to describe malaria epidemiological trends in Suriname between 2000 and 2016. The second objective is to identify spatiotemporal malaria trends in notification points between 2007 and 2016. METHODS: National malaria surveillance data resulting from active and passive screening between 2000 and 2016 were used for the temporal trend analysis...
November 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30413163/specificity-of-the-igg-antibody-response-to-plasmodium-falciparum-plasmodium-vivax-plasmodium-malariae-and-plasmodium-ovale-msp1-19-subunit-proteins-in-multiplexed-serologic-assays
#14
Jeffrey W Priest, Mateusz M Plucinski, Curtis S Huber, Eric Rogier, Bunsoth Mao, Christopher J Gregory, Baltazar Candrinho, James Colborn, John W Barnwell
BACKGROUND: Multiplex bead assays (MBA) that measure IgG antibodies to the carboxy-terminal 19-kDa sub-unit of the merozoite surface protein 1 (MSP119 ) are currently used to determine malaria seroprevalence in human populations living in areas with both stable and unstable transmission. However, the species specificities of the IgG antibody responses to the malaria MSP119 antigens have not been extensively characterized using MBA. METHODS: Recombinant Plasmodium falciparum (3D7), Plasmodium malariae (China I), Plasmodium ovale (Nigeria I), and Plasmodium vivax (Belem) MSP119 proteins were covalently coupled to beads for MBA...
November 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30409140/characterization-and-monitoring-of-deltamethrin-resistance-in-anopheles-culicifacies-in-the-presence-of-a-long-lasting-insecticide-treated-net-intervention
#15
Madhavinadha Prasad Kona, Raghavendra Kamaraju, Martin James Donnelly, Rajendra Mohan Bhatt, Nutan Nanda, Mehul Kumar Chourasia, Dipak Kumar Swain, Shrity Suman, Sreehari Uragayala, Immo Kleinschmidt, Veena Pandey
BACKGROUND: Deltamethrin-impregnated, long-lasting insecticidal nets (LLINs) were distributed in the study area from November 2014 to January 2015 to evaluate their impact on malaria transmission in the presence of insecticide-resistant vectors. Studies were carried out in 16 selected clusters in Keshkal sub-district, Chhattisgarh State, India to monitor and characterize deltamethrin resistance in Anopheles culicifacies sensu lato. RESULTS: Deltamethrin susceptibility of An...
November 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30409138/assessment-of-drug-resistance-associated-genetic-diversity-in-mauritanian-isolates-of-plasmodium-vivax-reveals-limited-polymorphism
#16
Jemila Mint Deida, Yacoub Ould Khalef, Emal Mint Semane, Mohamed Salem Ould Ahmedou Salem, Hervé Bogreau, Leonardo Basco, Ali Ould Mohamed Salem Boukhary, Rachida Tahar
BACKGROUND: Plasmodium vivax is the predominant malaria species in northern Mauritania. Molecular data on P. vivax isolates circulating in West Africa are scarce. The present study analysed molecular markers associated with resistance to antifolates (Pvdhfr and Pvdhps), chloroquine (Pvmdr1), and artemisinin (Pvk12) in P. vivax isolates collected in two cities located in the Saharan zone of Mauritania. METHODS: Blood samples were obtained from P. vivax-infected patients recruited for chloroquine therapeutic efficacy study in 2013 and febrile patients spontaneously consulting health facilities in Nouakchott and Atar in 2015-2016...
November 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30409136/g6pd-deficiency-primaquine-treatment-and-risk-of-haemolysis-in-malaria-infected-patients
#17
Sara Avalos, Rosa E Mejia, Engels Banegas, Cesar Salinas, Lester Gutierrez, Marcela Fajardo, Suzeth Galo, Alejandra Pinto, Angel Mejia, Gustavo Fontecha
BACKGROUND: The incidence of malaria in the Americas has decreased markedly in recent years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have set the goal of eliminating native malaria by the year 2020. To achieve this goal, Honduras has recently approved national regulations to expand the possibilities of a shortened double dose primaquine (PQ) treatment for vivax malaria. Considering this new shortened anti-malarial treatment, the high frequency of G6PDd genotypes in Honduras, and the lack of routinely assessment of the G6PD deficiency status, this study aimed at investigating the potential association between the intake of PQ and haemolysis in malaria-infected G6PDd subjects...
November 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30404640/towards-a-re-emergence-of-chloroquine-sensitivity-in-c%C3%A3-te-d-ivoire
#18
Oléfongo Dagnogo, Aristide Berenger Ako, Lacinan Ouattara, Noel Dougba Dago, David N'golo Coulibaly, André Offianan Touré, Joseph Allico Djaman
BACKGROUND: Resistance of Plasmodium falciparum to anti-malarial drugs has hampered efforts to eradicate malaria. Recent reports of a decline in the prevalence of chloroquine-resistant P. falciparum in several countries, including Malawi and Zambia, is raising the hope of reintroducing chloroquine in the near future, ideally in combination with another anti-malarial drug for the treatment of uncomplicated malaria. In Côte d'Ivoire, the decrease in the clinical efficacy of chloroquine, in addition to a high proportion of clinical isolates carrying the Thr-76 mutant allele of the pfcrt gene, had led to the discontinuation of the use of chloroquine in 2004...
November 7, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30400987/first-report-of-natural-wolbachia-infection-in-wild-anopheles-funestus-population-in-senegal
#19
El Hadji Amadou Niang, Hubert Bassene, Patrick Makoundou, Florence Fenollar, Mylène Weill, Oleg Mediannikov
BACKGROUND: Until very recently, Anopheles were considered naturally unable to host Wolbachia, an intracellular bacterium regarded as a potential biological control tool. Their detection in field populations of Anopheles gambiae sensu lato, suggests that they may also be present in many more anopheline species than previously thought. RESULTS: Here, is reported the first discovery of natural Wolbachia infections in Anopheles funestus populations from Senegal, the second main malaria vector in Africa...
November 6, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30400908/a-decade-since-sulfonamide-based-anti-malarial-medicines-were-limited-for-intermittent-preventive-treatment-of-malaria-among-pregnant-women-in-tanzania
#20
Alphonce I Marealle, Dennis P Mbwambo, Wigilya P Mikomangwa, Manase Kilonzi, Hamu J Mlyuka, Ritah F Mutagonda
BACKGROUND: Despite the development of resistance to Plasmodium falciparum malaria, sulfadoxine-pyrimethamine is still effective for intermittent preventive treatment of malaria in pregnancy (IPTp). In Tanzania, more than 10 years have passed since sulfadoxine-pyrimethamine and sulfamethopyrazine-pyrimethamine (SPs) were reserved for IPTp only. However, the retail pharmaceutical outlet dispensers' knowledge and their compliance with the policies have not been recently explored. Therefore, this study was designed to investigate dispensers' knowledge about these medications together with their actual dispensing practices, a decade since they were limited for IPTp use only...
November 6, 2018: Malaria Journal
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