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Lupus

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https://www.readbyqxmd.com/read/27913750/congenital-heart-block-and-immune-mediated-sensorineural-hearing-loss-possible-cross-reactivity-of-immune-response
#1
C Bason, I Pagnini, A Brucato, S Maestroni, A Puccetti, C Lunardi, R Cimaz
Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react with an epitope of SSA/Ro60 protein. Anti-Ro/SSA antibodies in pregnant women cross the placenta and reach the fetal tissues inducing an immune-mediated damage of the cardiac conduction system...
December 2, 2016: Lupus
https://www.readbyqxmd.com/read/27913749/belimumab-in-primary-antiphospholipid-syndrome
#2
A Yazici, B Yazirli, D Erkan
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and/or pregnancy morbidity with persistently positive antiphospholipid antibodies (aPL). Patients with aPL may also experience thrombocytopenia, cardiac valve disease, nephropathy, skin ulcer, or cognitive dysfunction, which are collectively known as non-criteria manifestations of APS. A description is provided of two primary APS patients who received belimumab (10 mg/kg) for an aPL-related manifestation.
December 2, 2016: Lupus
https://www.readbyqxmd.com/read/27913748/a-3-year-follow-up-of-a-patient-with-acute-renal-failure-caused-by-thrombotic-microangiopathy-related-to-antiphospholipid-syndrome-case-report
#3
X-J Zhou, M Chen, S-X Wang, F-D Zhou, M-H Zhao
BACKGROUND: Microvascular manifestations of antiphospholipid antibody syndrome in the kidneys include acute renal failure, thrombotic microangiopathy and hypertension. Therapy has been largely empiric. CASE REPORT: A 49-year-old Chinese man presented with anuric acute renal failure without abundant proteinuria and heavy haematuria, but markedly low levels of urinary sodium, potassium and chlorine upon admission. On day 1 of hospitalization, his thrombocytopenia, anaemia and renal failure showed rapid progression...
December 2, 2016: Lupus
https://www.readbyqxmd.com/read/27909160/evaluation-of-polymorphic-variants-in-apoptotic-genes-and-their-role-in-susceptibility-and-clinical-progression-to-systemic-lupus-erythematosus
#4
N Glesse, P Vianna, L M G Paim, M C C Matte, A K K Aguiar, P L Palhano, O A Monticielo, C V Brenol, R M Xavier, J A B Chies
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular events that coordinate apoptosis may favour the generation of autoantigens involved in autoimmunity. In this way, the apoptotic deregulation may be affected by polymorphic variants in apoptotic-related genes...
November 30, 2016: Lupus
https://www.readbyqxmd.com/read/27909159/review-by-hui-yuen-et%C3%A2-al-targeted-b-cell-therapies-in-the-treatment-of-adult-and-paediatric-systemic-lupus-erythematosus
#5
LETTER
D A Isenberg
No abstract text is available yet for this article.
November 30, 2016: Lupus
https://www.readbyqxmd.com/read/27879428/a-polymorphism-upstream-mir1279-gene-is-associated-with-pericarditis-development-in-systemic-lupus-erythematosus-and-contributes-to-definition-of-a-genetic-risk-profile-for-this-complication
#6
C Ciccacci, C Perricone, C Politi, S Rufini, F Ceccarelli, E Cipriano, C Alessandri, A Latini, G Valesini, G Novelli, F Conti, P Borgiani
Recently, a study has shown that a polymorphism in the region of MIR1279 modulates the expression of the TRAF3IP2 gene. Since polymorphisms in the TRAF3IP2 gene have been described in association with systemic lupus erithematosus (SLE) susceptibility and with the development of pericarditis, our aim is to verify if the MIR1279 gene variability could also be involved. The rs1463335 SNP, located upstream MIR1279 gene, was analyzed by allelic discrimination assay in 315 Italian SLE patients and 201 healthy controls...
November 22, 2016: Lupus
https://www.readbyqxmd.com/read/27879427/abnormality-in-hippocampal-signal-intensity-predicts-atrophy-in-patients-with-systemic-lupus-erythematosus
#7
A T Lapa, T Pedro, J Francischinelli, A C Coan, L T Lavras Costallat, F Cendes, S Appenzeller
OBJECTIVES: To quantify signal abnormalities in the hippocampus (Hsig) of patients with systemic lupus erythematosus (SLE) and to determine if Hsig predict hippocampal atrophy (HA) in SLE. METHODS: We included all SLE patients and healthy age- and sex-matched individuals with two magnetic resonance imaging (MRI) scans performed with a minimum of 1 year interval. All individuals underwent a standardized neuropsychological evaluation. Individual results were converted into standard scores and compared to normative data...
November 22, 2016: Lupus
https://www.readbyqxmd.com/read/27872396/comparison-of-estimates-of-body-fat-content-in-childhood-onset-systemic-lupus-erythematosus
#8
N A Sinicato, F A Peres, K de Oliveira Peliçari, A de Oliveira Santos, C D Ramos, R Marini, S Appenzeller
OBJECTIVE: We aimed to compare estimates of body fat content with respect to their ability to predict the percentage of body fat, confirmed by dual-energy X-ray absorptiometry scans in childhood-onset systemic lupus erythematosus. METHODS: We included 64 consecutive childhood-onset systemic lupus erythematosus patients and 64 healthy age and sex-matched controls in a cross-sectional study. Anthropometric data, body mass index and body adiposity index were calculated for all subjects...
November 21, 2016: Lupus
https://www.readbyqxmd.com/read/27852935/safety-pharmacokinetics-and-pharmacodynamics-of-rslv-132-an-rnase-fc-fusion-protein-in-systemic-lupus-erythematosus-a-randomized-double-blind-placebo-controlled-study
#9
D J Burge, J Eisenman, K Byrnes-Blake, P Smolak, K Lau, S B Cohen, A J Kivitz, R Levin, R W Martin, Y Sherrer, J A Posada
Blood-borne RNA circulating in association with autoantibodies is a potent stimulator of interferon production and immune system activation. RSLV-132 is a novel fully human biologic Fc fusion protein that is comprised of human RNase fused to the Fc domain of human IgG1. The drug is designed to remain in circulation and digest extracellular RNA with the aim of preventing activation of the immune system via Toll-like receptors and the interferon pathway. The present study describes the first clinical study of nuclease therapy in 32 subjects with systemic lupus erythematosus...
November 16, 2016: Lupus
https://www.readbyqxmd.com/read/27852934/acute-aortic-thrombosis-related-to-antiphospholipid-antibodies
#10
EDITORIAL
H Nakamura, O Amengual, T Horita, M Kato, K Oku, T Bohgaki, S Yasuda, T Atsumi
No abstract text is available yet for this article.
November 16, 2016: Lupus
https://www.readbyqxmd.com/read/27852933/prolactin-levels-are-associated-with-a-pro-inflammatory-body-mass-distribution-among-women-with-systemic-lupus-erythematosus
#11
C Elera-Fitzcarrald, M F Ugarte-Gil, R V Gamboa-Cárdenas, F Zevallos, M Medina, J M Cucho-Venegas, R A Perich-Campos, J L Alfaro-Lozano, Z Rodriguez-Bellido, G S Alarcón, C A Pastor-Asurza
OBJECTIVES: The objective of this study was to determine whether prolactin levels are associated with a pro-inflammatory body mass distribution in women with systemic lupus erythematosus (SLE). METHODS: This cross-sectional study was conducted in consecutive female SLE patients seen in our rheumatology department from January 2012 to July 2015. Prolactin was measured in ng/ml. Body mass distribution was measured by dual energy x-ray absorptiometry and it was divided into subtotal (whole body excluding the head), subtotal bone mineral content, lean mass index (appendicular lean mass/height(2)), subtotal trunk and leg fat percentages and trunk-to-leg fat ratio...
November 16, 2016: Lupus
https://www.readbyqxmd.com/read/27838681/ziprasidone-induced-sub-acute-cutaneous-lupus-erythematosus
#12
EDITORIAL
M Q Codina, L C Vila, G M Ninot, M S Redonnet
No abstract text is available yet for this article.
November 12, 2016: Lupus
https://www.readbyqxmd.com/read/27837198/comparison-of-ultrasonographic-joint-and-tendon-findings-in-hands-between-early-treatment-na%C3%A3-ve-patients-with-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#13
T Ogura, A Hirata, N Hayashi, S Takenaka, H Ito, K Mizushina, Y Fujisawa, M Imamura, N Yamashita, S Nakahashi, R Kujime, H Kameda
Although both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) may lead to joint deformity, SLE arthritis is typically non-erosive and often accompanied by Jaccoud's deformity. Therefore, we examined characteristics of joint and tendon lesions in patients with SLE and RA by ultrasonography. Fifteen treatment-naïve SLE patients and 40 treatment-naïve RA patients with joint symptoms were included in this study. The hand joints and related tendons were ultrasonographically examined using grey-scale (GS) and power Doppler (PD)...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27837197/comparison-of-ethnicity-gender-age-of-onset-and-outcome-in-south-africans-with-systemic-lupus-erythematosus
#14
A Budhoo, G M Mody, T Dubula, N Patel, P G Mody
Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58.1%) Indians, 137 (33.6%) African Blacks, 17 (4.2%) Mixed ethnicity and 17 (4.2%) Whites. The most common manifestations were arthritis (80.6%), photosensitivity (67.2%), oral ulcers (50.0%), malar rash (49.0%) and renal (39.2%). The common laboratory findings were positive anti-nuclear factor (96.8%), haematological (74...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27837196/abnormal-thymic-maturation-and-lymphoproliferation-in-mrl-faslpr-lpr-mice-can-be-partially-reversed-by-synthetic-oligonucleotides-implications-for-systemic-lupus-erythematosus-and-autoimmune-lymphoproliferative-syndrome
#15
R F Ashman, N Singh, P S Lenert
MRL-Fas (lpr/lpr) mice represent an excellent animal model for studying non-malignant lymphoproliferation, regeneration and systemic autoimmunity. Retro-transposon insertion into the second intron of the pro-apoptotic Fas gene appears to be responsible for both lymphoproliferation and autoimmunity, while other genes are more likely to contribute to the regenerative healing characteristic of this mouse strain. Previous studies have shown that neonatal thymectomy can halt the development of abnormal lymphoproliferation...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27837195/joint-ultrasound-baseline-abnormalities-predict-a-specific-long-term-clinical-outcome-in-systemic-lupus-erythematosus-patients
#16
P Corzo, T C Salman-Monte, V Torrente-Segarra, L Polino, S Mojal, J Carbonell-Abelló
OBJECTIVE: To describe long-term clinical and serological outcome in all systemic lupus erythematosus (SLE) domains in SLE patients with hand arthralgia (HA) and joint ultrasound (JUS) inflammatory abnormalities, and to compare them with asymptomatic SLE patients with normal JUS. METHODS: SLE patients with HA who presented JUS inflammatory abnormalities ('cases') and SLE patients without HA who did not exhibit JUS abnormalities at baseline ('controls') were included...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27837194/lenalidomide-for-refractory-cutaneous-manifestations-of-pediatric-systemic-lupus-erythematosus
#17
E Y Wu, L E Schanberg, E C Wershba, C E Rabinovich
OBJECTIVE: Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. METHODS: We performed a retrospective chart review of 10 adolescents who received lenalidomide for recalcitrant cutaneous lupus erythematosus...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27831540/time-trend-and-risk-factors-of-avascular-bone-necrosis-in-patients-with-systemic-lupus-erythematosus
#18
Sau Mei Tse, Chi Chiu Mok
OBJECTIVES: The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). METHODS: Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database and compared with those without AVN, matched for age, sex and SLE duration. The standardized incidence ratios (SIRs) of AVN in different SLE age groups were calculated from data derived from our hospital registry and population census...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27831539/incidence-and-prevalence-of-systemic-lupus-erythematosus-among-the-native-arab-population-in-uae
#19
A M Al Dhanhani, M Agarwal, Y S Othman, O Bakoush
BACKGROUND AND OBJECTIVES: There is a paucity of information about the epidemiology of systemic lupus erythematosus (SLE) amongst Arabs. The objective of this study was to determine the incidence and prevalence of SLE among the native Arab population of United Arab Emirates (UAE). METHODS: Patients with SLE were identified from three sources: medical records of two local tertiary hospitals (four years; 2009 to 2012), laboratory requests for serum double stranded deoxyribonucleic acid and serum anti-nuclear antibody and confirmed histopathologic diagnosis of SLE (skin and kidney biopsy specimens)...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27831538/proteinuria-selectivity-index-as-a-prognostic-biomarker-in-lupus-nephritis
#20
T Hasegawa, K Suzuki, Y Kaneko, T Takeuchi
OBJECTIVES: The selectivity index has been proposed in predicting the response to immunosuppressive therapy in nephrotic syndrome and other primary kidney disorders. The aim of this study was to elucidate the predictive value of the selectivity index for the treatment response and renal outcome in patients with lupus nephritis. METHODS: Forty-four patients with lupus nephritis with selectivity index available at the time of renal biopsy were divided into two groups according to the cut-off value of the selectivity index determined by a receiver operating characteristics curve to differentiate treatment responders from non-responders...
November 9, 2016: Lupus
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