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Liver Transplantation

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https://www.readbyqxmd.com/read/27884053/disability-in-patients-with-end-stage-liver-disease-results-from-the-functional-assessment-in-liver-transplantation-frailt-study
#1
Mariya L Samoylova, Kenneth E Covinsky, Marta Haftek, Selena Kuo, John P Roberts, Jennifer C Lai
: Cirrhosis leads to sarcopenia and functional decline that can severely impact one's ability to function at home and in society. Self-reported disability scales to quantify disability - Activities of Daily Living (ADL) and Instrumental ADL (IADL) - are validated to predict mortality in older adults. To evaluate disability in liver transplant (LT) candidates and quantify its impact on outcomes, consecutive outpatients ≥18y listed for LT with laboratory Model for End-stage Liver Disease (MELD) score ≥12 at a single high-volume U...
November 24, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27884044/reply-to-the-letter-to-the-editor-dual-kidney-transplantation-in-liver-transplant-recipients
#2
LETTER
Marco Di Laudo, Matteo Ravaioli, Gaetano La Manna, Giorgia Comai, Matteo Cescon, Massimo Del Gaudio, Valentina Bertuzzo, Chiara Zanfi, Alessandro Cucchetti, And Antonio Daniele Pinna
No abstract text is available yet for this article.
November 24, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27884043/considerations-about-the-importance-of-cytokines-expression-for-optimizing-liver-graft-metabolism-during-normothermic-machine-perfusion
#3
LETTER
Davide Ghinolfi, Laura Caponi, Lorella Marselli, Daniele Pezzati, Maria Franzini, Paolo De Simone, Vanna Fierabracci, Piero Marchetti, Aldo Paolicchi, Franco Filipponi
No abstract text is available yet for this article.
November 24, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27880991/vascular-complications-in-living-donor-liver-transplantation-at-a-high-volume-centre-evolving-protocols-and-trends-observed-over-10-years
#4
A R Shiraz, M A Nayeem, S Agarwal, N Goyal, S Gupta
Vascular complications continue to have devastating effect; although their nature, incidence and outcome might have actually changed with increasing experience and proficiency in high volume centers. Aim was to analyze the trends observed in vascular complications with changing protocols in adult and pediatric- living donor liver transplantation (A-LDLT and P-LDLT) over 10 years in two time frames in terms of nature, incidence and outcome. It is a retrospective analysis of 391 (Group I= Jan. 2006- Dec.2010) and 741 (Group II= Jan...
November 23, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27880979/low-dose-lipopolysaccharide-causes-biliary-injury-by-blood-biliary-barrier-impairment-in-a-rat-hepatic-ischemia-reperfusion-model
#5
J Reiling, K R Bridle, M Gijbels, F G Schaap, L Jaskowski, N Santrampurwala, L J Britton, C M Campbell, S W M Olde Damink, D H G Crawford, C H C Dejong, J Fawcett
INTRODUCTION: This study explored whether bacterial endotoxins, in the form of lipopolysaccharides (LPS), could have an injurious effect on the biliary tract in conjunction with ischemia. METHOD: Sixty-four rats were randomly assigned to four groups: sham operation (sham), 1mg/kg LPS i.p. (LPS), hepatic ischemia reperfusion (IR), and IR combined with LPS (IR+LPS). Following 1 or 6 hours of reperfusion, serum liver tests, bile duct histology, immunofluorescence microscopy (zonula occludens-1), bile composition (bile salts, phospholipids, lactate dehydrogenase), hepatic gene expression (bile salt transporters and inflammatory mediators) as well as serum and biliary cytokine concentrations were quantified and compared between the study groups...
November 23, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27875639/long-term-follow-up-of-small-pancreatic-cystic-lesions-in-liver-transplant-recipients
#6
Sirachat Vidhyarkorn, Surachate Siripongsakun, Jennifer Yu, James Sayre, Vatche M Agopian, Francisco Durazo, David S Lu
BACKGROUND: Incidental small pancreatic cystic lesions (PCLs) are often found on pre-operative imaging in patients undergoing orthotropic liver transplantation (OLT).While these are considered benign or of low malignant potential, the influence of immunosuppression after OLT may be of concern. The aim of this study was to observe the long term outcome of these small pancreatic cystic lesions (PCLs) in post OLT patients. METHODS: An institutional OLT database of 1,778 consecutive OLT patients from January 2000 to December 2010 was analyzed...
November 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27875636/evaluation-of-coronary-artery-disease-in-potential-liver-transplant-recipients
#7
REVIEW
Brian J Hogan, Enoka Gonsalkorala, Michael A Heneghan
Improvements in the management of patients undergoing Liver Transplantation (LT) have resulted in a significant increase in survival over recent years. Cardiac disease is now the leading cause of early mortality and the stress of major surgery, haemodynamic shifts, the possibility of haemorrhage or reperfusion syndrome require the recipient to have good baseline cardiac function. The prevalence of coronary artery disease (CAD) is increasing in liver transplant candidates, especially in those with Non-Alcohol related Fatty Liver Disease (NAFLD)...
November 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27874250/immunosuppression-in-pediatric-liver-transplant-recipients-unique-aspects
#8
REVIEW
Miloh Tamir, Barton Andrea, Wheeler Justin, Pham Yen, Hewitt Winston, Keegan Tara, Sanchez Christine, Bulut Pinar, Goss John
Pediatric liver transplantation has experienced improved outcomes over the last 50 years. This can be attributed in part to establishing optimal use of immunosuppressive agents to achieve a balance between minimizing the risks of allograft rejection and infection. The management of immunosuppression in children is generally more complex and can be challenging when compared to the use of these agents in adult liver transplant patients. Physiologic differences in children alter the pharmacokinetics of immunosuppressive agents, which affects absorption, distribution, metabolism and drug excretion...
November 22, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27862931/percutaneous-creation-of-biliary-enteric-neo-anastomosis-for-anastomotic-biliary-occlusion-following-living-donor-liver-transplantation
#9
Colin McCarthy, Ashraf Thabet, Kei Yamada, Peter Mueller, Parsia Vagefi
No abstract text is available yet for this article.
November 10, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27862929/effects-of-recipient-size-and-allograft-type-on-pediatric-liver-transplantation-for-biliary-atresia
#10
Sophoclis P Alexopoulos, Victor Nekrasov, Shu Cao, Susan Groshen, Navpreet Kaur, Yuri S Genyk, Lea Matsuoka
RATIONALE: The majority of pediatric patients with end stage liver disease receive a transplant with a whole liver allograft. However, smaller recipients with biliary atresia may have improved outcomes with deceased donor partial liver or living donor allografts. This study compares the national outcomes for liver transplantation in biliary atresia, with attention to the interaction between liver allograft type and recipient size. RESULTS: From 1/2/2002 to 12/30/2014, 2123 pediatric patients underwent a primary liver transplant for biliary atresia...
November 10, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27862900/long-term-renal-allograft-survival-after-sequential-liver-kidney-transplantation-from-a-single-living-donor
#11
Kumiko Kitajima, Yuichi Ogawa, Katsuyuki Miki, Kotaro Kai, Akihito Sannomiya, Kazuhiro Iwadoh, Toru Murakami, Ichiro Koyama, Ichiro Nakajima, Shohei Fuchinoue
Background Combined liver-kidney transplantation (CLKT) is well-established as a definitive therapy with the potential to provide complete recovery for certain liver-kidney diseases, although the results might be contingent on the cause of transplantation. The purposes of the present study were to review the long-term outcome of renal allografts in CLKT patients from single living donors and to investigate the beneficial factors, compared with solitary renal transplantation. Materials and Methods Thirteen patients underwent sequential liver (LTx) and kidney (KTx) transplantations from single living donors...
November 10, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27809409/24-hour-normothermic-machine-perfusion-of-discarded-human-liver-grafts
#12
Thomas Vogel, Jens G Brockmann, Alberto Quaglia, Alireza Morovat, Wayel Jassem, Nigel D Heaton, Constantin C Coussios, Peter J Friend
Background Donor organ shortage necessitates use of less than optimal donor allografts for transplantation. Current cold storage preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation (NMP) of liver allografts. In this study, we analyse discarded human liver grafts that underwent NMP for the extended period of 24 hours. Methods Thirteen human liver grafts which had been discarded for transplantation, were entered into this study...
November 3, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27809404/financial-impact-of-share-35-encouraging-early-results-but-many-unanswered-questions
#13
EDITORIAL
Therese Bittermann, David S Goldberg
No abstract text is available yet for this article.
November 3, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27809402/ligation-cut-as-a-method-for-bile-duct-division-in-living-donor-right-hepatectomy
#14
Seong Hoon Kim, Eung Chang Lee, Seung Duk Lee, Sang Jae Park
: The importance of bile duct division cannot be overemphasized in living donor surgery. The ligation & cut (LC) as a method for bile duct division in living donor right hepatectomy (LDRH) has never been reported. The purpose of this study was to introduce the LC method of bile duct division in LDRH. All LDRH donors were identified through a prospectively maintained database at the authors' institution between September 2009 and March 2013, and the two methods, LC and cut & oversewing (CO), were compared both in terms of donor and recipient outcomes of right lobe living donor liver transplantation (LDLT)...
November 3, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27805302/marginal-quality-kidneys-for-simultaneous-liver-kidney-transplant-to-pass-or-double-down
#15
EDITORIAL
Suphamai Bunnapradist, Gabriel M Danovitch
No abstract text is available yet for this article.
November 2, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27786407/defining-disparities-in-liver-transplantation-the-devil-is-in-the-details
#16
David Goldberg
No abstract text is available yet for this article.
October 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27783463/dual-kidney-transplantation-in-liver-transplant-recipients
#17
LETTER
Burcin Ekser, Cristina Silvestre, Lucrezia Furian
No abstract text is available yet for this article.
October 26, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27783460/efficacy-of-hydrodynamic-il10-gene-transfer-in-human-liver-segments-with-interest-in-transplantation
#18
Luis Sendra Gisbert, Antonio Miguel Matas, Luis Sabater Ortí, María José Herrero Cervera, Laura Sabater Olivas, Eva María Montalvá Orón, Matteo Frasson, Rafael Abargues López, Rafael López-Andújar, Eduardo García-Granero Ximénez, Salvador Francisco Aliño Pellicer
: Different diseases lead, during their advanced stages, to chronic or acute liver failure, whose unique treatment consists in organ transplantation. The success of intervention is limited by host immune response and graft rejection. Immunosuppressant drugs permitted improving organ transplantation but they cannot completely solve the problem and their management is delicate, especially during the early stages of treatment. Thus, new tools to set an efficient modulation of immune response are required...
October 26, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27783454/successful-donation-after-cardiac-death-liver-transplants-with-prolonged-warm-ischemia-time-using-normothermic-regional-perfusion
#19
R De Carlis, S Di Sandro, A Lauterio, F Ferla, A Dell'Acqua, M Zanierato, L De Carlis
The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited by the incidence of primary non-function (PNF) and ischemia-related complications. Even greater concern exists towards uncontrolled DCD, which represents the largest potential pool of DCD donors. We recently started the first Italian series of DCD liver transplantation, using normothermic regional perfusion (NRP) in 6 uncontrolled donors and in 1 controlled case to deal with the legally required no-touch period of 20 minutes...
October 26, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27779823/portopulmonary-hypertension-and-liver-transplantation-a-duo-in-question
#20
EDITORIAL
Michael J Krowka, Julie K Heimbach
No abstract text is available yet for this article.
October 25, 2016: Liver Transplantation
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