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Liver Transplantation

Kristopher P Croome, David D Lee, Surakit Pungpapong, Andrew P Keaveny, C Burcin Taner
INTRODUCTION: The tragedy of the national opioid epidemic has resulted in a significant increase in the number of opioid related deaths and accordingly an increase in the number of potential donors designated PHS increased risk. Previous studies have demonstrated reluctance to utilize these PHS organs and as a result, higher discard rates for these organs have been observed. METHODS: All patients listed for LT in the United States from January 2005 to December 2016 were investigated...
January 17, 2018: Liver Transplantation
Samarth S Patel, Eiman Nabi, Luis Guzman, Antonio Abbate, Chandra Bhati, Richard T Stravitz, Trevor Reichman, Scott C Matherly, Carolyn Driscoll, Hannah Lee, Velimir A Luketic, Richard K Sterling, Arun J Sanyal, Vaishali Patel, Marlon Levy, Mohammad Shadab Siddiqui
Coronary artery disease (CAD) is an important contributor to morbidity and mortality in patients undergoing liver transplantation (LT). However, the current literature is limited by sampling bias and non-definitive assessment of CAD. AIM: The current study examines the prevalence of CAD via per protocol coronary angiography and its relationship to etiology of liver disease in patients undergoing LT evaluation (LTE). METHODS: Data on 228 patients was prospectively collected who had coronary angiography as part of LTE between 2011-2014...
January 12, 2018: Liver Transplantation
Mingxuan Feng, Ping Wan, Bijun Qiu, Tao Zhou, Yi Luo, Lihong Gu, Jiachang Chi, Chengpeng Zhong, Yefeng Lu, Jianjun Zhang, Qiang Xia
BACKGROUND: An atretic or hypoplastic portal vein (PV) represents a challenge for PV reconstruction in pediatric living donor liver transplantation (LDLT). Several PV venoplastic techniques have been developed. However, we still seek improved venoplastic techniques with better efficacy and compatibility. METHOD: From June 2016 to July 2017, 271 LDLT procedures were performed at the Department of Liver Surgery, Ren Ji Hospital. A total of 16 consecutive children with atretic and sclerotic PVs underwent a novel technique - the autogenous PV patch plastic technique...
January 12, 2018: Liver Transplantation
Andrew Wey, Joshua Pyke, David P Schladt, Sommer E Gentry, Tim Weaver, Nicholas Salkowski, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
Offer acceptance practices may cause geographic variability in allocation model for end-stage liver disease score (aMELD) at transplant and could magnify the effect of donor supply and demand on aMELD variability. To evaluate these issues, offer acceptance practices of liver transplant programs and donation service areas (DSAs) were estimated using offers of livers from donors recovered between January 1, 2016, and December 31, 2016. Offer acceptance practices were compared with liver yield, local placement of transplanted livers, donor supply and demand, and aMELD at transplant...
January 9, 2018: Liver Transplantation
Ting-Chin David Shen, Nikolaos Pyrsopoulos, Vinod K Rustgi
No abstract text is available yet for this article.
January 6, 2018: Liver Transplantation
Qiang Liu, Ahmed Nassar, Laura Buccini, Patrick Grady, Basem Soliman, Ahmed Hassan, Daniele Pezzati, Giuseppe Iuppa, Teresa Diago Uso, Charles Miller, Cristiano Quintini
No abstract text is available yet for this article.
January 6, 2018: Liver Transplantation
Zhi-Bin Zhang, Lei Liu, Wei Gao, Yuan Shi, Ning Ma, Zhong-Yang Shen
No abstract text is available yet for this article.
January 5, 2018: Liver Transplantation
Mohamed Safwan, Shunji Nagai, Kelly Collins, Michael Rizzari, Atsushi Yoshida, Marwan Abouljoud
While minimally invasive techniques for living donor hepatectomy have been developed, the surgical feasibility and limitations remain to be elucidated. The risks and outcomes involved need to be better understood prior to their widespread application. The aim of this study was to assess feasibility of minimally invasive donor hepatectomy by reviewing our experience. A total of 99 living donor liver transplantation (LDLTs) performed between 2000 and 2016 were retrospectively reviewed. All 99 living liver donors underwent right hepatectomy...
December 27, 2017: Liver Transplantation
Alix P M Matton, Laura C Burlage, Rianne van Rijn, Yvonne de Vries, Shanice A Karangwa, Maarten W Nijsten, Annette S H Gouw, Janneke Wiersema-Buist, Jelle Adelmeijer, Andrie C Westerkamp, Ton Lisman, Robert J Porte
BACKGROUND: Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed using human blood products including red blood cells (RBC) and fresh frozen plasma (FFP). Our aim was to examine the efficacy of a novel machine perfusion solution based on polymerized bovine hemoglobin HBOC-201. METHODS: Twenty-four livers declined for transplantation were transported using static cold storage. Upon arrival, livers underwent NMP for 6 hours using pressure-controlled portal and arterial perfusion...
December 27, 2017: Liver Transplantation
R Cutler Quillin, James V Guarrera
A finite supply of donor organs has led many transplant centers to accept marginal liver allografts with increasing frequency. These allografts may be at higher risk of primary non-function, early allograft dysfunction and other recipient complications following liver transplantation. Machine perfusion preservation is an emerging technology that limits ischemia-reperfusion injury associated with preservation and may lead to improved outcomes following transplantation. Increased used of machine perfusion in liver preservation may permit an expansion of the donor pool...
December 26, 2017: Liver Transplantation
Manuela Cesaretti, Nicolas Poté, Francois Cauchy, Federica Dondero, Safi Dokmak, Ailton Sepulveda, Anne Sophie Schneck, Claire Francoz, Francois Durand, Valerie Paradis, Olivier Soubrane
No abstract text is available yet for this article.
December 22, 2017: Liver Transplantation
Zobair Younossi
No abstract text is available yet for this article.
December 22, 2017: Liver Transplantation
Carlo Dl Ceresa, David Nasralla, Constantin-C Coussios, Peter J Friend
In recent years there has been growing interest in normothermic machine perfusion as a preservation method in liver transplantation. In most countries, due to a donor organ shortage, an unacceptable number of patients die whilst awaiting transplantation. In an attempt to increase the number of donor organs available, transplant teams are implanting a greater number of high-risk livers; including those from donors after circulatory death, older donors and with steatosis. Normothermic machine perfusion maintains the liver ex vivo on a circuit by providing oxygen and nutrition at 37°C...
December 22, 2017: Liver Transplantation
Mathew Jacob, Rehan Saif, Jayanth Reddy, Noushif M, Sonal Asthana, Rajiv Lochan
No abstract text is available yet for this article.
December 21, 2017: Liver Transplantation
Concepcion Gomez Gavara, Prashant Bhangui, Chady Salloum, Michael Osseis, Francesco Esposito, Toufic Moussallem, Eylon Lahat, Liliana Fuentes, Philippe Compagnon, Norbert Ngongang Coord Nurse, Chetana Lim, Daniel Azoulay
The management of large spontaneous porto-systemic shunt (SPSS) during liver transplantation is a matter of debate. The aim of this study is to compare the short- and long-term outcomes of SPSS ligation vs. non-ligation during liver transplantation, when both options are available. From 2011 to 2017, 66 patients with SPSS underwent liver transplantation: 56 without and 10 with portal vein thrombosis all of which underwent successful thrombectomy, and could have porto-portal reconstruction. The SPSS were either spleno-renal (40, 61...
December 21, 2017: Liver Transplantation
A Shingina, M I Montenovo
No abstract text is available yet for this article.
December 20, 2017: Liver Transplantation
Mikel Gastaca, Mikel Prieto, Ibone Palomares, Andrés Valdivieso
No abstract text is available yet for this article.
December 14, 2017: Liver Transplantation
Richard N Formica
No abstract text is available yet for this article.
December 9, 2017: Liver Transplantation
Ulrich Baumann, René Adam, Christophe Duvoux, Rafael Mikolajczyk, Vincent Karam, Lorenzo D'Antiga, Christophe Chardot, Ahmet Coker, Michele Colledan, Bo-Goran Erizon, Pål Dag Line, Nedim Hadzic, Helena Isoniemi, Jürgen L Klempnauer, Raymond Reding, Patrick J McKiernan, Valérie McLin, Andreas Paul, Mauro Salizzoni, Emanuel San Bento Furtado, Stefan Schneeberger, André Karch
Hepatocellular carcinoma (HCC) in childhood differs from adult HCC as it is often associated with inherited liver disease. It is, however, unclear whether liver transplantation (LT) for HCC in childhood with or without associated inherited disease has a comparable outcome to adult HCC. Based on data from the European Liver Transplant Registry (ELTR) we aimed to investigate if there are differences in patient and graft survival after LT for HCC between children and adults and between patients with underlying inherited versus non inherited liver disease respectively...
December 9, 2017: Liver Transplantation
Roberto Montalti, Andrea Benedetti Cacciaguerra, Daniele Nicolini, Emad Alì Ahmed, Martina Coletta, Lesley De Pietri, Andrea Risaliti, Roberto Ivan Troisi, Federico Mocchegiani, Marco Vivarelli
BACKGROUND: The preservation of a graft's aberrant left hepatic artery (LHA) during liver transplantation (LT) ensures optimal vascularization of the left liver but can also be considered a risk factor for hepatic artery thrombosis. In contrast, ligation of an aberrant LHA may lead to hepatic ischaemia with the potential risk of graft dysfunction and biliary complications. The aim of this study was to prospectively analyse the impact on the surgical strategy for LT of 5 tests performed to establish whether an aberrant LHA was an accessory or a replaced artery, thus leading to the design of a decisional algorithm...
December 6, 2017: Liver Transplantation
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