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Liver Transplantation

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https://www.readbyqxmd.com/read/28618184/big-improvements-for-the-smallest-recipients
#1
EDITORIAL
Adam D Griesemer, Jean C Emond
No abstract text is available yet for this article.
June 15, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28618164/is-liver-transplant-education-patient-centered
#2
Yanik J Bababekov, Zhi Ven Fong, David C Chang, Mary Ann Simpson, Heidi Yeh, James J Pomposelli
No abstract text is available yet for this article.
June 15, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28618096/perioperative-use-of-terlipressin-in-adult-liver-transplant
#3
EDITORIAL
Sunil Taneja, Y K Chawla
No abstract text is available yet for this article.
June 15, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590599/reply
#4
LETTER
Ping-Chun Li, Ashok Thorat, Long-Bin Jeng
No abstract text is available yet for this article.
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590598/28-year-incidence-of-de-novo-malignancies-after-liver-transplantation-a-single-center-analysis-of-risk-factors-and-mortality-in-1616-patients
#5
S Rademacher, D Seehofer, D Eurich, W Schoening, R Neuhaus, R Oellinger, T Denecke, A Pascher, E Schott, M Sinn, P Neuhaus, J Pratschke
BACKGROUND: De novo malignancies are one of the leading causes of late mortality after liver transplantation (LT). METHODS: We analyzed 1616 consecutive patients who underwent LT between 1988 and 2006 at our institution. All patients were prospectively observed over a study period of 28 years by our own outpatient clinic. Complete follow up data were available for 96% of patients, 3% were incomplete and only 1% were lost to follow-up. The median follow-up of the patients was 14...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590589/living-donor-liver-transplantation-for-post-kasai-biliary-atresia-analysis-of-pretransplant-predictors-of-outcomes-in-infants
#6
Toshihiro Kitajima, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Soichi Narumoto, Akinari Fukuda, Satoshi Teramukai, Shinji Uemoto, Mureo Kasahara
After decades of dramatic surgical innovations in pediatric living donor liver transplantation (LDLT), LDLT for biliary atresia (BA) still poses various challenges. This study reviewed our experience with LDLT for children with post-Kasai BA and evaluated outcomes and prognostic factors. From 2005 to 2016, 168 post-Kasai BA LDLT patients were enrolled and divided into three groups by age. Patient characteristics and perioperative data were compared. Predictors of morbidity and mortality following LDLT were analyzed in 93 infants...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590564/-beta-blockers-in-patients-with-advanced-liver-disease-has-the-dust-settled
#7
REVIEW
Carlos Moctezuma-Velazquez, Sylvia Kalainy, Juan G Abraldes
Non-selective beta blockers (NSBBs) have been the backbone for the treatment of portal hypertension in cirrhosis for the last three decades. A publication in 2010 of a prospective observational study suggested that NSBBs could increase mortality in patients with refractory ascites. This opened a controversy about the safety and efficacy of NSBBs in patients with advanced liver disease and led to the publication of a large corpus of observational data assessing the safety of NSBBs in patients with advanced cirrhosis...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590550/osi-027-modulates-acute-graft-versus-host-disease-after-liver-transplantation-in-a-rat-model
#8
Xiao Zhi, Fei Xue, Wei Chen, Chao Liang, Hao Liu, Tao Ma, Xuefeng Xia, Liqiang Hu, Xueli Bai, Tingbo Liang
Despite its rarity (1%-2%), acute graft-versus-host disease after liver transplantation (LTx-aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (T-regs) correlates with disease progression in a rat LTx-GVHD model and treatments which increase T-regs exert therapeutic effects on LTx-aGVHD. In this study, LTx-aGVHD model rats were treated with rapamycin (RAPA), OSI-027 or an equal quantity of vehicle. Rats treated with OSI-027 survived longer (>100 days) than those in the RAPA (70±8 days) or control (24±3 days) groups...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590542/the-donor-risk-index-a-decade-of-experience
#9
REVIEW
Avegail Flores, Sumeet K Asrani
In 2006, derivation of the donor risk index (DRI) highlighted the importance of donor factors for successful liver transplantation. Over the last decade, the DRI has served as a useful metric of donor quality and enhanced our understanding of donor factors and their impact upon recipients with hepatitis C, those with low model for end-stage liver disease (MELD) score, and individuals undergoing retransplantation. DRI has provided the transplant community with a common language for describing donor organ characteristics and has served as the foundation for several tools for organ risk assessment...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590523/hepatic-artery-reconstruction-in-living-donor-liver-transplantation-using-surgical-loupes-achieving-low-rate-of-hepatic-arterial-thrombosis
#10
LETTER
Toru Ikegami, Tomoharu Yoshizumi, Hideaki Uchiyama, Yuji Soejima, Noboru Harada, Yoshihiko Maehara
No abstract text is available yet for this article.
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28590520/developing-multicenter-consortia-in-liver-disease-in-latin-america-challenges-and-opportunities
#11
REVIEW
Manuel Mendizabal, Marcelo O Silva
Developmentof consortiums have been useful for exploringchallengingscenarios and unchartered territoriesin liver diseases. Several consortia already developed in the United States and Europehave become key factors in patient care decision making processes, medical education and also impacting upon policy makers decisions. In Latin America the situation is different. As a result of a combination of different factors our region has not been able to take off in terms of networking advantages in research and education in liver diseases...
June 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28544291/in-response-to-is-liver-transplant-education-patient-centered
#12
LETTER
Marina Serper, Michael S Wolf
No abstract text is available yet for this article.
May 23, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28544587/drop-out-rate-from-the-liver-transplant-waiting-list-due-to-hcc-progression-in-hcv-infected-patients-treated-with-direct-acting-antivirals
#13
Alberto Zanetto, Sarah Shalaby, Alessandro Vitale, Claudia Mescoli, Alberto Ferrarese, Martina Gambato, Enrica Franceschet, Giacomo Germani, Marco Senzolo, Antonietta Romano, Paolo Angeli, Massimo Rugge, Fabio Farinati, Daniel M Forton, Umberto Cillo, Patrizia Burra, Francesco Paolo Russo
BACKGROUND & AIM: concerns about an increased hepatocellular carcinoma (HCC) recurrence rate following directly acting antiviral (DAA) therapy in cirrhotic patients with a prior complete oncological response have been raised. Data regarding the impact of HCV-treatment with DAAs on waiting list drop-out rates in patients with active HCC and HCV-related cirrhosis awaiting liver transplantation (LT) are lacking. MATERIALS AND METHODS: HCV-HCC patients listed for LT between January 2015 and May 2016 at Padua Liver Transplant Centre were considered eligible for the study...
May 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28544246/liver-transplantation-for-colo-rectal-liver-metastasis-survival-without-recurrence-can-be-achieved
#14
Christian Toso, Hugo Pinto Marques, Axel Andres, Francisco Castro Sousa, René Adam, Antonio Kalil, Pierre-Alain Clavien, Emanuel Furtado, Eduardo Barroso, Henri Bismuth
No abstract text is available yet for this article.
May 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28524363/donor-transmitted-mutation-of-the-abcb11-gene-and-ensuing-intra-hepatic-cholestasis-of-pregnancy-in-a-liver-transplant-recipient
#15
Tiong Yeng Lim, Iona Coltart, Pierre Foskett, Richard Thompson, Sandra Strautnieks, Leonie Penna, Catherine Williamson, Rosa Miquel, Michael A Heneghan
In liver transplant (LT) recipients, the cause of graft dysfunction in pregnancy is often difficult to ascertain. Moreover, a liver biopsy in late pregnancy is often avoided as a consequence of patient and physician factors. Management of graft dysfunction can be difficult in this setting. We report a 30-year-old female LT recipient who developed acutely deranged liver biochemistry during the third trimester of her first pregnancy. At 29 weeks gestation, her liver function test (LFT) became abnormal; AST peaked at 978 IU/L (normal range 10-50), GGT 25 IU/L (normal range 1-55), bilirubin 1...
May 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28512923/the-braden-scale-a-standard-tool-for-assessing-pressure-ulcer-risk-predicts-early-outcomes-after-liver-transplantation
#16
Vinay Sundaram, Jane Lim, Danielle M Tholey, Sentia Iriana, Irene Kim, Vignan Manne, Nicholas N Nissen, Andrew S Klein, Tram T Tran, Walid S Ayoub, Barry Schlansky
The Braden Scale is a standardized tool to assess pressure ulcer risk, that is reported for all hospitalized patients in the United States (US) per requirements of the Center for Medicare and Medicaid Services. Previous data has shown the Braden Scale can predict both frailty and mortality risk in patients with decompensated cirrhosis. Our aim was to evaluate the association of Braden Scale score with short-term outcomes after liver transplantation (LT). We performed a retrospective cohort study of deceased-donor LT recipients at two centers, and categorized them according to the Braden Scale at hospital admission as low (>18), moderate (16-18), or high risk (<16) for pressure ulcer...
May 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28481005/mesenchymal-stem-cells-attenuate-acute-liver-injury-by-altering-ratio-between-il-17-producing-and-regulatory-nkt-cells
#17
Neda Milosavljevic, Marina Gazdic, Bojana Simovic Markovic, Aleksandar Arsenijevic, Jasmin Nurkovic, Zana Dolicanin, Valentin Djonov, Miodrag L Lukic, Vladislav Volarevic
Mesenchymal stem cells (MSCs) are, due to immunomodulatory characteristics, considered as novel agents in the treatment of immune-mediated acute liver failure. Although it is known that MSCs can regulate activation of T lymphocytes, their capacity to modulate function of neutrophils and NKT cells, major interleukin (IL)-17 producing cells in acute liver injury, is still unknown. By using two well established murine models of neutrophil and NKT cell mediated acute liver failure (induced by Carbon tetrachloride (CCl4 ) and alphagalactoceramide (α-GalCer)), we investigated molecular and cellular mechanisms involved in MSC-mediated modulation of IL-17 signaling during acute liver injury...
May 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28480517/the-clinical-outcomes-of-patients-with-portal-vein-tumor-thrombi-after-living-donor-liver-transplantation
#18
Ho Joong Choi, Dong Goo Kim, Gun Hyung Na, Tae Ho Hong, Si Hyun Bae, Young Kyoung You, Jong Young Choi, Seung Kew Yoon
INTRODUCTION: The purpose of this study was to evaluate the feasibility of living-donor liver transplantation (LDLT) for treatment of patients with hepatocellular carcinoma (HCC) and segmental portal vein tumor thrombi (PVTT) below the second-order branch. PATIENTS AND METHODS: Between January 2005 and December 2015, we retrospectively analyzed 242 patients in a control group (n = 184), a microvascular invasion (MVI) group (n = 24), and a PVTT group (n = 34). To assess the risks associated with PVTT, we evaluated recurrence, the disease-free survival rate (DFS), the overall survival rate (OS), and various other factors based on the characteristics of patients and tumors...
May 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28452116/beta-blockers-in-advanced-cirrhotics-red-light-green-light-yellow-light%C3%A2
#19
EDITORIAL
Thoetchai Bee Peeraphatdit, Patrick S Kamath, Vijay H Shah
No abstract text is available yet for this article.
April 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28431203/donor-safety-in-living-donor-liver-transplantation-the-korean-organ-transplantation-registry-kotry-study
#20
Jae Geun Lee, Kwang-Woong Lee, Choon Hyuck David Kwon, Chong Woo Chu, Bong-Wan Kim, Dong Lak Choi, Young Kyoung You, Dong-Sik Kim, Yang Won Nah, Koo Jeong Kang, In Soek Choi, Hee Chul Yu, Geun Hong, Ho-Seong Han, Shin Hwang, Myoung Soo Kim
Major concerns about donor safety cause controversy and limit the use of living donor liver transplantation to overcome organ shortages. The Korean Organ Transplantation Registry established a nationwide organ transplantation registration system in 2014. We reviewed the prospectively collected data of all 832 live liver donors who underwent procedures between April 2014 and December 2015. We allocated the donors to a left lobe group (n=59) and a right lobe group (n=773) and analyzed the relations between graft types and remaining liver volumes and complications (graded using the Clavien five-tier grading system)...
April 21, 2017: Liver Transplantation
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