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Liver Transplantation

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https://www.readbyqxmd.com/read/28340509/liver-transplant-lt-recipients-with-nonalcoholic-steatohepatitis-nash-have-lower-risk-hepatocellular-carcinoma-hcc
#1
Sara M Lewin, Neil Mehta, R Kate Kelley, John P Roberts, Francis Y Yao, Danielle Brandman
BACKGROUND: Liver transplantation is a well-established treatment for HCC in carefully selected patients. Risk factors for tumors with poor prognostic features on explant have not been well described in a national cohort. METHODS: We performed a retrospective cohort study of adult LT recipients with HCC transplanted from 4/8/12 (when explant pathology in UNOS became available) until 9/30/2014. We evaluated the association between listing diagnosis and other demographic factors with tumor features on explant using logistic regression...
March 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28340504/improving-the-outcomes-of-hiv-hcv-coinfected-transplant-recipients-the-answer-is-blowin-in-the-wind
#2
EDITORIAL
Ghady Haidar, Nina Singh
No abstract text is available yet for this article.
March 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28318147/effects-of-alfapump-system-on-kidney-and-circulatory-function-in-patients-with-cirrhosis-and-refractory-ascites
#3
Elsa Solà, Santiago Sanchez-Cabús, Ezequiel Rodriguez, Chiara Elia, Raquel Cela, Rebeca Moreira, Elisa Pose, Jordi Sánchez-Delgado, Nuria Cañete, Manuel Morales-Ruiz, Francisco Campos, Jaume Balust, Mónica Guevara, Juan Carlos García-Valdecasas, Pere Ginès
The alfapump system has been proposed as a new treatment for the management of refractory ascites. The system removes ascites from the peritoneal cavity to urinary bladder, producing a continuous low-volume paracentesis. AIM: To investigate the effects of treatment with the alfapump system on kidney and circulatory function in patients with cirrhosis and refractory ascites. METHODS: Prospective study including 10 patients with cirrhosis and refractory ascites. Primary outcomes were changes in glomerular filtration rate (GFR), as assessed by isotopic techniques, and changes in circulatory function assessed by arterial pressure, cardiac output and activity of vasoconstrictor systems...
March 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28296066/liver-transplantation-with-donation-after-cardiac-death-donors-as-a-strategy-for-recipients-with-meld%C3%A2-%C3%A2-15-has-the-die-been-cast
#4
EDITORIAL
Vatche G Agopian
No abstract text is available yet for this article.
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28296011/vedolizumab-is-safe-and-effective-in-moderate-to-severe-inflammatory-bowel-disease-following-liver-transplantation
#5
Andrew P Wright, Robert J Fontana, Ryan W Stidham
No abstract text is available yet for this article.
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28295992/liver-transplantation-versus-liver-resection-for-hepatocellular-carcinoma-in-intention-to-treat-attempt-to-perform-an-ideal-meta-analysis
#6
REVIEW
Benjamin Menahem, Jean Lubrano, Christophe Duvoux, Andrea Mulliri, Arnaud Alves, Charlotte Costentin, Ariane Mallat, Guy Launoy, Alexis Laurent
Objective This meta-analysis compared the effects of liver transplantation (LT) and liver resection (LR) on overall survival (OS) and disease-free survival (DFS) in patients with hepatocellular carcinoma (HCC) small transplantable HCC or within Milan criteria. Methods Articles comparing LR with LT for HCC, based on Milan criteria or small size, published until June 2015 were selected and a meta-analysis performed. Results No randomized controlled trial (RCT) has been published to date comparing survival outcomes in patients with HCC who underwent LR and LT...
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28295986/a-surge-in-cadaveric-liver-donors-and-a-national-narcotic-epidemic-is-there-an-association
#7
Matthew Goss, Jeffrey Reese, Michael Kueht, John M Vierling, Ayse L Mindikoglu, Norman L Sussman, Bruce Kaplan, R Patrick Wood, Abbas A Rana
No abstract text is available yet for this article.
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28294557/double-blind-randomized-controlled-trial-of-the-routine-peri-operative-use-of-terlipressin-in-adult-living-donor-liver-transplantation
#8
Mettu Srinivas Reddy, Ilankumaran Kaliamoorthy, Akila Rajakumar, Selvakumar Malleeshwaran, Ellango Appuswamy, Sukanya Lakshmi, Joy Varghese, Mohamed Rela
BACKGROUND: Peri-operative terlipressin (Tp) during living donor liver transplantation (LDLT) has been shown to reduce intra-operative portal pressures and improve renal function. Its role and safety profile has never been evaluated in a double-blinded RCT. AIM: To evaluate the haemodynamic effects, clinical benefits and safety of peri-operative terlipressin infusion in adult LDLT. METHODS: This was a single centre double-blind RCT. Consenting adults with chronic liver disease and low risk of post-transplant renal dysfunction (PTRD) undergoing their first LDLT were randomized...
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28294533/evaluation-of-donor-workups-and-exclusions-in-a-single-center-experience-of-living-donor-liver-transplantation
#9
Adianto Nugroho, Ok-Kyung Kim, Kwang-Woong Lee, Sanghee Song, Hyeyoung Kim, Suk Kyun Hong, Kyung Chul Yoon, Hyo-Sin Kim, YoungRok Choi, Hae Won Lee, Nam-Joon Yi, Kyung-Suk Suh
The process of evaluating potential donors in liver transplantation is important to ensure donor safety and provide optimal recipient outcome. However, there has been no report about donor exclusion rates and reasons for such exclusion in Korea. In this study, we aimed to elucidate the outcomes of potential live liver donor evaluation in a major LDLT center. From July 2011 to June 2015, prospectively collected data of 726 potential donors for 588 matched recipients were subsequently evaluated. Among 726 potential donors, 374 potential donors (51...
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28294516/peri-transplant-pancreatitis-a-marker-of-high-mortality-and-graft-failure-in-liver-transplant-patients
#10
Tara A Russell, Sarah Park, Vatche G Agopian, Ali Zarrinpar, Douglas G Farmer, Sean O'Neill, Islam Korayem, Samer Ebaid, Jeffrey Gornbein, Ronald W Busuttil, Fady M Kaldas
Perioperative pancreatitis is a significant comorbid condition in surgical patients, however the degree to which pancreatitis affects graft and overall survival in liver transplant recipients has not been evaluated. This study assesses the impact of pancreatitis on graft and patient survival in adult orthotopic liver transplantation (OLT). All patients undergoing OLT at a single academic institution from 2007-2015 were reviewed. Pancreatitis was classified by method of diagnosis (intra-operative or radiographic (IO/R) versus isolated serologic (IS)) and timing (pre-operative versus post-operative)...
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240843/venous-stent-in-liver-transplant-candidates-dodging-the-top-tip-traps
#11
A Merdrignac, H Jeddou, P Houssel-Debry, E Flecher, M Rayar, K Boudjema
No abstract text is available yet for this article.
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240840/liver-transplant-modulates-gut-microbial-dysbiosis-and-cognitive-function-in-cirrhosis
#12
Jasmohan S Bajaj, Andrew Fagan, Masoumeh Sikaroodi, Melanie B White, Richard K Sterling, HoChong Gilles, Douglas Heuman, R T Stravitz, Scott C Matherly, Mohammed S Siddiqui, Puneet Puri, Arun J Sanyal, Velimir Luketic, Binu John, Michael Fuchs, Vishwadeep Ahluwalia, Patrick M Gillevet
Liver transplant (LT) improves daily function and cognition in cirrhosis but a subset can remain impaired. Unfavorable microbiota or dysbiosis is observed in cirrhosis but the effect of LT on microbial composition; especially with poor post-LT cognition, is unclear. AIMS: (1) determine the effect of LT on gut microbiota and (b) to determine whether gut microbiota are associated with cognitive dysfunction post-LT. We enrolled outpatient cirrhotics on the LT list and followed them till 6 months post-LT...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240817/liver-ex-vivo-machine-perfusion-preservation-a-review-of-the-methodology-and-results-of-large-animal-studies-and-clinical-trials
#13
REVIEW
Hazel Marecki, Adel Bozorgzadeh, Robert Porte, Henri Leuvenink, Korkut Uygun, Paulo Martins
Ex-vivo machine perfusion is a promising way to better preserve livers prior to transplantation. Currently, no methodology has verified benefit over simple cold storage. Before becoming clinically feasible, machine perfusion requires validation in models that reliably predict human performance. Such a model has been found in porcine liver, who's physiological, anatomical, and immunological characteristics closely resemble the human liver. Since the 1930s, researchers have explored machine perfusion as preservation, but only recently have clinical trials been performed...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240812/reconstruction-of-anomalous-portal-venous-branching-in-right-lobe-living-donor-liver-transplantation-malatya-approach
#14
Sezai Yilmaz, Cuneyt Kayaalp, Burak Isik, Veysel Ersan, Emrah Otan, Sami Akbulut, Abuzer Dirican, Ramazan Kutlu, Aysegul Sagir Kahraman, Cengiz Ara, Mehmet Yilmaz, Bulent Unal, Cemalettin Aydin, Turgut Piskin, Dincer Ozgor, Mustafa Ates, Fatih Ozdemir, Volkan Ince, Cemalettin Koc, Adil Baskiran, Sait Murat Dogan, Bora Barut, Fatih Sumer, Serdar Karakas, Koray Kutluturk, Saim Yologlu, Harika Gozukara
BACKGROUND: Reconstruction of anomalous portal venous branching (APVB) during right lobe living donor liver transplantation (LDLT) can be challenging. OBJECTIVE: To describe our surgical technique, named the Malatya Approach, in case of APVP during right lobe LDLT. The technique includes the unification of the APVB and to obtain a funnel shaped common extension with a circumferential fence by a saphenous vein conduit. METHODS: Total 126 (10...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240808/prognostic-effect-of-tace-induced-complete-pathological-response-in-patients-undergone-liver-resection-and-transplantation-for-hepatocellular-carcinoma
#15
Woo-Hyoung Kang, Shin Hwang, Gi-Won Song, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Dong-Hwan Jung, Gil-Chun Park, Sung-Gyu Lee
Transcatheter arterial chemoembolization (TACE)-induced complete pathological response (CPR) is known to improve post-resection outcomes of hepatocellular carcinoma (HCC). We aimed to assess the prognostic effects of CPR after preoperative TACE for HCC in patients who underwent hepatic resection (HR) or liver transplantation (LT). The clinical outcomes of patients showing CPR after HR (n=110) or LT (n=233) were analyzed. The control groups comprised patients with minimal recurrence risk as naïve single HCC ≤2 cm for HR (n=476), and one or two HCCs ≤2 cm for LT (n=184)...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240807/genetic-hematological-and-immunological-disorders-transmissible-with-liver-transplantation
#16
REVIEW
Amy Tan, Sander S Florman, Thomas D Schiano
It is well recognized that solid organ transplantation can transmit bacterial infection, chronic viral hepatitis as well as certain cancers. As indications for liver transplantation have expanded, it has been used to treat and even cure certain genetic cholestatic disorders, urea cycle defects and coagulation abnormalities; many of these conditions are potentially transmissible with liver transplantation as well. It is important for clinicians and transplant patients to be aware of these potentially transmissible conditions as unexplained post-liver transplant complications can sometimes be related to donor transmission of disease and thus should prompt a thorough exploration of the donor allograft history...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240805/a-multi-center-study-to-define-sarcopenia-in-patients-with-end-stage-liver-disease
#17
Elizabeth J Carey, Jennifer C Lai, Connie W Wang, Srinivasan Dasarathy, Iryna Lobach, Aldo J Montano-Loza, Michael A Dunn
Sarcopenia is associated with increased waitlist mortality, but a standard definition is lacking. In this retrospective study, we sought to determine the optimal definition of sarcopenia in end-stage liver disease (ESLD) patients awaiting LT. Included were 396 patients newly listed for LT in 2012 at five North American transplant centers. All CT scans were read by two individuals with inter-observer correlation of 98%. Using image analysis software, the total cross-sectional area (cm(2) ) of abdominal skeletal muscle at L3 was measured...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28240804/share-35-changes-center-level-liver-acceptance-practices
#18
David S Goldberg, Matthew Levine, Seth Karp, Richard Gilroy, Peter L Abt
Share 35 was implemented to provide improved access to organs for patients with MELD scores ≥35. However, little is known about the impact of Share 35 on organ offer acceptance rates. We evaluated all liver offers to adult patients that were ultimately transplanted between 1/1/2011-12/31/2015. The analyses focused on patients ranked in the top five positions of a given match run, and used multi-level mixed-effects models, clustering on individual waitlist candidate and transplant center. There was a significant interaction between Share 35 era and MELD category (p<0...
February 27, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28236364/intra-gastric-migration-of-a-mesenterico-portal-polytetrafluoroethylene-ptfe-jump-graft-after-liver-transplantation
#19
Francesco Esposito, Chetana Lim, Chady Salloum, Michael Osseis, Laurence Baranes, Aurelien Amiot, Philippe Compagnon, Daniel Azoulay
No abstract text is available yet for this article.
February 25, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28220684/living-donor-liver-transplantation-during-the-first-three-months-of-life
#20
Mureo Kasahara, Seisuke Sakamoto, Kengo Sasaki, Hajime Uchida, Toshihiro Kitajima, Takanobu Shigeta, Soichi Narumoto, Yoshihiro Hirata, Akinari Fukuda
BACKGROUND: Living donor liver transplantation is now an established technique for treating children with end-stage liver disease. Few data exist about liver transplantation for exclusively young infants, especially infants of <3 months of age. We report our single-center experience with 12 cases in which living donor liver transplantation (LT) was performed during the first 3 months of life and compare the results with those of older infants who underwent LT. All of the patients were treated at the National Center of Child Health and Development, Tokyo, Japan...
February 21, 2017: Liver Transplantation
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