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Liver Transplantation

journal
https://www.readbyqxmd.com/read/28192869/prioritization-for-liver-transplantation-reconsidering-survival-benefit
#1
EDITORIAL
Andrew P Keaveny, C Burcin Taner
No abstract text is available yet for this article.
February 13, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28188668/hiv-infected-liver-transplant-recipients-with-incidental-hepatocellular-carcinoma-a-prospective-multicenter-nationwide-cohort-study
#2
Fernando Agüero, Alejandro Forner, Andrés Valdivieso, Marino Blanes, Rafael Barcena, Christian Manzardo, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Pilar Barrera-Baena, Luisa González-Diéguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jiménez-Pérez, José Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos Del Campo, Itxarone Bilbao, Carlos Jiménez Romero, Asunción Moreno, Antoni Rimola, José M Miro
: There is a lack of data on incidental hepatocellular carcinoma (iHCC) in the setting of liver transplantation (LT) in HIV infected patients. This study aims to describe the frequency, histopathological characteristics and outcomes of HIV-infected LT recipients with iHCC from a Spanish, multicenter cohort in comparison with a matched cohort of LT patients without HIV infection. Fifteen (6%) out of 271 patients with HIV infection who received LT in Spain from 2002-2012 and 38 (5%) out of the 811 HIV-uninfected counterparts presented iHCC in liver explants (p=0...
February 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28187520/exogenous-vegf-delivery-prior-to-endothelial-precursor-cell-transplantation-in-orthotopic-liver-transplant-induced-hepatic-ischemia-reperfusion-injury
#3
Ding Cao, Menghao Wang, Junhua Gong, Sidong Wei, Jianping Gong, Jinzheng Li
BACKGROUND: Vascular endothelial growth factor (VEGF) promotes angiogenesis in vivo. We hypothesized that exogenous delivery of VEGF prior to bone marrow-derived endothelial precursor cell (EPC) transplantation may improve orthotopic liver transplantation (OLT)-induced hepatic ischemia-reperfusion injury (HIRI). METHODS: OLT between Sprague Dawley donor rats and inbred LEW Wistar recipient rats was performed in six experimental groups to comparatively assess the effects of VEGF gene: an untreated normal control group, a surgical control group, a liposomal control group, a VEGF group receiving only the liposome-encapsulated VEGF plasmid, an EPC group receiving only EPCs, and an EPC+VEGF group receiving the liposome-encapsulated VEGF plasmid followed by EPCs...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28187503/beneficial-and-harmful-effects-of-non-selective-beta-blockade-on-acute-kidney-injury-in-liver-transplant-candidates
#4
Sang Gyune Kim, Joseph J Larson, Ji Sung Lee, Therneau M Terry, W Ray Kim
Non-selective beta-blockers have played an important role in the prevention of portal hypertensive bleeding in cirrhotic patients. However, recent studies have suggested that non-selective beta-blockers may be harmful in some patients with end-stage liver disease. To evaluate the association between use of non-selective beta-blocker and the incidence of acute kidney injury (AKI). We conducted a nested case-control study in a cohort of liver transplant waitlist registrants. Each patient with AKI was matched to a control by the model for end-stage liver disease (MELD)-Na score, age, serum creatinine, and follow-up duration...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28187493/recurrence-of-hepatocellular-carcinoma-after-liver-transplantation-is-there-a-place-for-resection
#5
Elena Fernandez-Sevilla, Marc-Antoine Allard, Jasmijn Selten, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Castaing Denis, René Adam
INTRODUCTION: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role of surgery is uncertain in this case. The purpose of this study was to identify the prognostic factors of survival after post-LT HCC recurrence and evaluate the impact of surgery in this setting. PATIENTS AND METHODS: All patients transplanted for HCC between 1991 and 2013 in a single institution and who further developed a post-LT recurrence were included in this study...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28176451/epidemiology-and-risk-factors-for-infection-after-living-donor-liver-transplantation
#6
Cybele Lara R Abad, Brian D Lahr, Raymund R Razonable
BACKGROUND: The epidemiology of infections after living donor liver transplantation is limited. We aimed to study the epidemiology and risk factors of infections after living donor liver transplantation. METHODS: The medical records of 223 adult patients who underwent living donor liver transplantation from January 1, 2000 - August 31, 2015 were reviewed for all infections occurring up to 1 year. We estimated the cumulative incidence of infection using the Kaplan Meier product limit method...
February 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28164428/side-stream-dark-field-videomicroscopy-for-evaluating-liver-microcirculation-in-vivo
#7
EDITORIAL
Stephen J Wigmore, Gabriel C Oniscu
No abstract text is available yet for this article.
February 6, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28160412/defining-disparities-in-liver-transplantation-the-devil-is-in-the-details
#8
LETTER
Ryutaro Hirose, Julie Heimbach
No abstract text is available yet for this article.
February 4, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28160394/cardiovascular-morbidity-and-mortality-after-liver-transplantation-the-protective-role-of-mycophenolate-mofetil
#9
D D'Avola, V Cuervas-Mons, J Martí, J Ortiz de Urbina, L Lladó, C Jimenez, E Otero, F Suarez, J M Rodrigo, M A Gómez, E Fraga, P Lopez, T Serrano, A Rios, E Fábrega, J I Herrero
: Cardiovascular (CV) diseases are recognized long-term causes of death after liver transplantation (LT). The objective of this multicenter study was to analyse the prevalence and the evolution of CV risk factors and CV morbidity and mortality in 1819 liver transplant recipients along 5 years after LT. The influence of baseline variables on survival, morbidity and mortality was studied. There was a continuous and significant increase of the prevalence of all the CV risk factors (except smoking) after LT...
February 3, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28152578/pten-%C3%AE-catenin-signaling-modulates-regulatory-t-cells-and-inflammatory-responses-in-mouse-liver-ischemia-and-reperfusion-injury
#10
Qiang Zhu, Changyong Li, Kunpeng Wang, Shi Yue, Longfeng Jiang, Michael Ke, Ronald W Busuttil, Jerzy W Kupiec-Weglinski, Feng Zhang, Ling Lu, Bibo Ke
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays an important role in regulating T cell activation during inflammatory response. Activation of β-catenin is crucial for maintaining immune homeostasis. This study investigates the functional roles and molecular mechanisms by which PTEN-β-catenin signaling promotes regulatory T cell (Treg) induction in a mouse model of liver ischemia and reperfusion injury (IRI). We found that mice with myeloid specific PTEN knockout (PTEN(M-KO) ) exhibited reduced liver damage as evidenced by decreased levels of serum ALT, intrahepatic macrophage trafficking, and pro-inflammatory mediators compared to the PTEN-proficient (PTEN(FL/FL) ) controls...
February 2, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28152572/safety-and-efficacy-of-transhepatic-and-transsplenic-access-for-endovascular-management-of-portal-vein-complications-after-liver-transplantation-1
#11
Joon-Young Ohm, Gi-Young Ko, Kyu-Bo Sung, Dong-Il Gwon, Heung-Gyu Koh
OBJECTIVE: To evaluate and compare the safety and efficacy of endovascular management of the portal vein (PV) via percutaneous transsplenic access versus percutaneous transhepatic access in liver transplant recipients. METHODS: Eighteen patients who underwent endovascular management of PV via percutaneous transhepatic (n = 8) and transsplenic (n = 10) access were enrolled. Transsplenic access was chosen if the spleen was located in a normal position, the splenic vein was preserved, and the target lesion did not involve confluence of the superior mesenteric and splenic veins...
February 2, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28152569/changing-pattern-of-biliary-complications-in-an-evolving-liver-transplant-unit
#12
A Rammohan, S Govil, J Vargese, V Kota, M S Reddy, M Rela
BACKGROUND: Biliary complications remain a significant cause of morbidity following liver transplantation. This series of 640 Liver transplant recipients with a blend of living and deceased donor transplants was analyzed to determine the incidence, risk factors, management protocol and outcomes in these patients. METHODS: Review of a prospectively collected database of transplant recipients operated between Aug 2009 and June 2016 was performed. Patients were divided into those with and without biliary complications and data was analyzed...
February 2, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133947/serious-gaming-for-orthotopic-liver-transplant-anesthesiology-a-randomized-control-trial
#13
Daniel Katz, Jeron Zerillo, Sang Kim, Bryan Hill, Ryan Wang, Andrew Goldberg, Samuel DeMaria
: Anesthetic management of orthotopic liver transplantation (OLT) is complex. Given the unequal distributions of liver transplant surgeries performed at different centers, anesthesiology providers receive relatively uneven OLT training and exposure. One well-suited modality for OLT training is the "serious game", an interactive application created for the purpose of imparting knowledge or skills, while leveraging the self-motivating elements of video games. We therefore developed a serious game designed to teach best practices for the anesthetic management of a standard OLT and determined if the game would improve resident performance in a simulated OLT...
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133934/a-novel-immune-function-biomarker-identifies-patients-at-risk-of-clinical-events-early-following-liver-transplantation
#14
Siddharth Sood, Craig Haifer, Lijia Yu, Julie Pavlovic, Leonid Churilov, Paul J Gow, Robert M Jones, Peter W Angus, Kumar Visvanathan, Adam G Testro
: Balancing immunosuppression after liver transplant is difficult, with clinical events common. We investigate whether a novel immune biomarker based on a laboratory platform with widespread availability that measures interferon gamma (IFNγ) after stimulation with a lyophilized ball containing an adaptive and innate immune stimulant can predict events following transplantation. 75 adult transplant recipients were prospectively monitored in a blinded, observational study. 55/75 (73.3%) patients experienced a total 89 clinical events...
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133933/the-possibility-of-radiotherapy-as-downstaging-to-living-donor-liver-transplantation-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus
#15
J Y Choi, J I Yu, H C Park, C H D Kwon, J M Kim, J-W Joh, G S Choi, J B Park, S J Kim, S H Lee, W-T Cho, K W Lee, B-G Na, D K Oh, N R Lee, C W Cho, S Lee, S-K Lee
: Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are difficult to manage with very poor survival and due to universal recurrence after liver transplantation, they have been excluded from indication. Conformer radiation therapy (RT) has been shown to be effective in the treatment of HCC but only few trials have been reported as bridge to liver transplantation (LT) in HCC with PVTT. The purpose of our study was to evaluate the possibility of applying living donor liver transplantation (LDLT) following successful downstaging using RT in advanced HCC with PVTT...
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133898/high-dose-opioid-use-and-liver-transplantation-an-underestimated-problem
#16
EDITORIAL
Shari Rogal, Mary Amanda Dew, Andrea DiMartini
No abstract text is available yet for this article.
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28133883/carbon-monoxide-ameliorates-hepatic-ischemia-reperfusion-injury-via-sirtuin1-mediated-deacetylation-of-hmgb1-in-rats
#17
Jian Sun, Enshuang Guo, Jiankun Yang, Yan Yang, Shenpei Liu, Jifa Hu, Xiaojing Jiang, Olaf Dirsch, Uta Dahmen, Wei Dong, Anding Liu
: Carbon monoxide (CO) exerts protective effects on hepatic ischemia/reperfusion (I/R) injury, but the underlying molecular mechanisms are not fully understood. High mobility group box 1 (HMGB1) is an important mediator of injury and inflammation in hepatic I/R injury. Here, we investigated whether CO could attenuate hepatic I/R injury via inhibition of HMGB1 release, particularly through sirtuin 1 (SIRT1). CO was released by treatment with CO-releasing molecule (CORM)-2. CORM-2-delivered CO ameliorated hepatic I/R injury, as indicated by lower serum aminotransferase levels, lower hepatic inflammatory responses and less severe I/R-associated histopathologic changes...
January 30, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28124458/hepatic-ischemia-reperfusion-injury-associates-with-acute-kidney-injury-in-liver-transplantation-prospective-cohort-study
#18
Ina Jochmans, Nicolas Meurisse, Arne Neirynck, Marleen Verhaegen, Diethard Monbaliu, Jacques Pirenne
: Solid clinical prospective studies investigating the association between hepatic ischemia reperfusion injury and acute kidney injury after liver transplantation are missing. Hepatic ischemia reperfusion injury -reflected by transaminase release- induces acute kidney injury in rodents and retrospective studies suggest a similar association in man. This prospective cohort study determined risk factors for acute kidney injury in 80 adult liver-only recipients. Acute kidney injury -defined by RIFLE-criteria- developed in 21 (26%) recipients at 12 hours postreperfusion [inter quartile range: 6 hours-postoperative day 1]; 13 progressed from "Risk" to "Injury"; 5 to "Failure"...
January 25, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28109055/treatment-of-hepatitis-c-virus-infection-in-children-time-for-action
#19
EDITORIAL
Giuseppe Indolfi, Lorenzo D'Antiga
No abstract text is available yet for this article.
January 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28103652/presence-of-small-pancreatic-cystic-lesions-should-not-preclude-liver-transplantation
#20
EDITORIAL
Jodie A Barkin, Jamie S Barkin
No abstract text is available yet for this article.
January 19, 2017: Liver Transplantation
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20192
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