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Liver Transplantation

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https://www.readbyqxmd.com/read/28734130/right-lobe-living-donors-ages-55-and-older-in-liver-transplantation
#1
Seong Hoon Kim, Eung Chang Lee, Jae Ryong Shim, Sang Jae Park
Insufficient is the evidence for safe use of elderly donors in adult-to-adult living donor liver transplantation (LDLT). The aim of this study was to evaluate the outcomes of right lobe LDLT by donor age (≥55 vs. <55 years). All living donors who underwent right hepatectomy at the authors' institution between March 2008 and December 2015 were divided into 2 groups: group A with an age ≥ 55 and group B with an age < 55. The selection criteria for elderly donor were preservation of middle hepatic vein, remnant liver volume ≥30%, and no or mild fatty liver...
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28734125/a-systematic-review-and-meta-analysis-of-cold-in-situ-perfusion-and-preservation-of-the-hepatic-allograft-working-towards-a-unified-approach
#2
REVIEW
Ahmer M Hameed, Jerome M Laurence, Vincent W T Lam, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: The efficacy of cold in situ perfusion and static storage of the liver is one possible determinant of transplantation outcomes. The aim of this study was to determine whether there is evidence to substantiate a preference for a particular perfusion route (aortic or dual) or perfusion/preservation solution in donation after brain-death (DBD) liver transplantation. METHODS: The Embase, Medline and Cochrane databases were utilized (1980-2017). Random effects modeling was used to estimate effects on transplantation outcomes based upon (i) aortic or dual in situ perfusion, and (ii) the use of University of Wisconsin (UW), histidine-tryptophan-ketoglutarate (HTK), Celsior and/or Institut Georges Lopez-1 (IGL-1) for perfusion/preservation...
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28734124/steatotic-donor-livers-where-is-the-risk-benefit-maximized
#3
Matyas Hamar, Markus Selzner
No abstract text is available yet for this article.
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28734123/transplant-for-the-very-sick-no-limitations-in-donor-quality
#4
Jennifer Lai
No abstract text is available yet for this article.
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28734122/portal-venous-stenosis-following-liver-transplant-role-of-transsplenic-intervention
#5
EDITORIAL
M H Doshi, J Salsamendi, G Narayanan
No abstract text is available yet for this article.
July 22, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28722785/direct-acting-antivirals-and-recurrence-of-hepatocellular-carcinoma
#6
EDITORIAL
Jorge A Marrero, Amit G Singal
No abstract text is available yet for this article.
July 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28719133/critical-elements-in-pediatric-allograft-selection
#7
George V Mazariegos
No abstract text is available yet for this article.
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28719075/fibrosis-in-small-syngeneic-rat-liver-grafts-due-to-damaged-bone-marrow-stem-cells-from-chronic-alcohol-consumption
#8
Masayuki Hisada, Xiuying Zhang, Yoshihiro Ota, Andrew M Cameron, James Burdick, Bin Gao, George Melville Williams, Zhaoli Sun
A patient with liver failure due to chronic and acute alcohol abuse under consideration for an urgent liver transplant shortly after stopping alcohol may have residual abnormalities that threaten transplant success, particularly for a small graft. To address this, we studied a model in which reduced size (50%) Lewis rat livers are transplanted into green fluorescence protein (GFP) transgenic Lewis recipients after they are fed alcohol or a control diet for 5 weeks. Here we show that normal small Lewis grafts transplanted to alcohol fed Lewis hosts developed fibrosis whereas no fibrosis was observed in control fed recipients...
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28719072/living-donor-liver-transplantation-ldlt-in-high-meld-score-patients
#9
Sandy Feng
No abstract text is available yet for this article.
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28719070/sirtuin-1-attenuates-inflammation-and-hepatocellular-damage-in-liver-transplant-ischemia-reperfusion-from-mouse-to-human
#10
Kojiro Nakamura, Shoichi Kageyama, Bibo Ke, Takehiro Fujii, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Hepatic ischemia-reperfusion injury (IRI), an inevitable antigen-independent inflammation response in cadaveric liver transplantation, correlates with poor early graft function, rejection episodes, and contributes to donor organ shortage. Sirtuin 1 (SIRT1) is a histone deacetylase which may regulate inflammatory cell activity and manage liver function in IRI, though its functional role and clinical relevance remains to be elucidated. We investigated the efficacy of SIRT1 activation in murine liver IRI model and verified the concept of putative SIRT1-mediated hepatoprotection in clinical liver transplantation...
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28700814/alternative-outflow-reconstruction-in-domino-liver-transplantation
#11
Carmen Cepeda-Franco, Luis Miguel Marín-Gómez, Carmen Bernal-Bellido, Gonzalo Suárez-Artacho, Jose María Álamo-Martínez, Francisco Javier Padillo-Ruiz, Miguel Ángel Gómez-Bravo
No abstract text is available yet for this article.
July 12, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28691231/active-immunization-for-prevention-of-de-novo-hbv-infection-after-adult-living-donor-liver-transplantation-with-hbc-graft
#12
Shih-Ho Wang, Poh-Yen Loh, Ting-Lung Lin, Li-Man Lin, Wei-Feng Lee, Yu-Hung Lin, Chih-Che Lin, Chao-Long Chen
Background De novo hepatitis B infection (DNHB) may occur in recipients who do not receive prophylaxis after liver transplantation (LT) with anti-HBc(+) donor grafts. Active immunization has been shown to prevent DNHB in pediatric recipients. Our aim is to investigate the efficacy of HBV vaccination for preventing DNHB in adult living donor LT (LDLT). Patients and Methods 71 adult HBsAg(-) LDLT patients who received anti-HBc(+) grafts from 2000 to 2010 were enrolled into this study. Patients were given HBV vaccinations with the aim of achieving anti-HBs >1000 IU/L pre-transplant and >100 IU/L post-transplant...
July 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28688155/critical-care-management-of-the-cirrhotic-patient-awaiting-liver-transplant-in-the-intensive-care-unit
#13
REVIEW
J C Olson, C J Karvellas
Patients with cirrhosis who are awaiting liver transplantation are at high risk for development of critical illness. Current liver allocation policies which dictate a "sickest first" approach coupled with a mismatch between need and availability of organs results in longer wait times and thus, patients are becoming increasingly ill while awaiting organ transplantation. Even patients with well compensated cirrhosis may suffer acute deterioration, the syndrome of acute-on-chronic liver failure (ACLF) results in multi-system organ dysfunction and a marked increase in associated short-term morbidity and mortality...
July 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28688140/pro-acute-on-chronic-liver-failure
#14
REVIEW
Elsa Solà, Pere Ginès
No abstract text is available yet for this article.
July 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28688158/determination-of-hepatocellular-carcinoma-grade-by-needle-biopsy-is-unreliable-for-liver-transplant-candidate-selection
#15
Colin M Court, Michael P Harlander-Locke, Daniela Markovic, Samuel W French, Bita V Naini, David S Lu, Steven S Raman, Fady M Kaldas, Ali Zarrinpar, Douglas G Farmer, Richard S Finn, Saeed Sadeghi, James S Tomlinson, Ronald W Busuttil, Vatche G Agopian
OBJECTIVE: To evaluate the utility of preoperative needle biopsy (PNB) grading of hepatocellular carcinoma (HCC) as a biomarker for liver transplant (LT) candidate selection. BACKGROUND: Given the prognostic significance of HCC tumor grade, PNB grading has been proposed as a biomarker for LT candidate selection. METHODS: Clinicopathologic characteristics of HCC LT recipients (1989-2014) with a PNB were analyzed, and concordance of PNB grade to explant grade and vascular invasion was assessed to determine whether incorporation of PNB grade to accepted transplant criteria improved candidate selection...
July 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28688150/national-assessment-of-early-hospitalization-after-liver-transplantation-risk-factors-and-association-with-patient-survival
#16
Pratima Sharma, Nathan P Goodrich, Douglas E Schaubel, Abigail R Smith, Robert M Merion
Hospitalization is known to occur frequently in the first 6 months following liver transplantation (LT). Using a novel data linkage between the Scientific Registry of Transplant Recipients and Centers for Medicare and Medicaid Services, our study has two objectives: (i) determine risk factors for "early" hospitalization (i.e., within 6 months of LT) (ii) quantify the importance of hospitalization history in the first 6 months with respect to subsequent patient survival (i.e., survival, conditional on surviving 6 months post-LT)...
July 7, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650115/previous-live-donor-hemi-hepatectomy-as-cadaveric-donor-of-remnant-liver
#17
John C LaMattina, Samuel Sultan, Steven I Hanish, David A Bruno, Paul J Thuluvath, Anurag Maheshwari, Rolf N Barth
No abstract text is available yet for this article.
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650112/liver-graft-preservation-using-perfluorocarbon-improves-the-outcomes-of-simulated-donation-after-cardiac-death-liver-transplantation-in-rats
#18
Shinya Okumura, Tadahiro Uemura, Xiangdong Zhao, Yuki Masano, Tatsuaki Tsuruyama, Yasuhiro Fujimoto, Taku Iida, Shintaro Yagi, Dmitri Bezinover, Bruce Spiess, Toshimi Kaido, Shinji Uemoto
INTRODUCTION: The outcomes of liver transplantation from donation after cardiac death (DCD) donors remain poor due to the severe warm ischemic injury. Perfluorocarbon (PFC) is a novel compound with high oxygen carrying capacity. In the present study, a rat model simulating DCD liver transplantation was used, and the impact of improved graft oxygenation provided by PFC addition on liver ischemia-reperfusion injury (IRI) and survival after DCD liver transplantation was investigated. MATERIAL AND METHODS: Orthotopic liver transplants were performed in male Lewis rats, using DCD liver grafts preserved with cold University of Wisconsin (UW) solution in the control group and preserved with cold oxygenated UW solution with addition of 20% PFC in the PFC group...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650108/a-matched-pair-analysis-of-multicenter-long-term-follow-up-after-split-liver-transplantation-with-extended-right-grafts
#19
M W Ross, M Cescon, R Angelico, E Andorno, G Rossi, A Pinna, L De Carlis, U Baccarani, U Cillo, M Colledan, V Mazzaferro, G Tisone, M Rossi, F Tuzzolino, D Pagano, S Gruttadauria, G Mazariegos, B Gridelli, M Spada
Split liver transplantation has been proposed as an alternative to whole liver transplantation to expand the donor pool, but studies comparing adult long-term outcomes between the two methods are conflicting and limited. This is the first Italian multicenter study that retrospectively analyzed 119 matched-pair recipients of whole and extended right grafts for long-term survival outcomes. In the overall population, whole liver recipients showed higher patient survival at one- (93% vs. 73%), five- (87% vs. 65%) and ten-year (83% vs...
June 26, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28650101/con-acute-on-chronic-liver-failure
#20
REVIEW
John O'Grady
No abstract text is available yet for this article.
June 26, 2017: Liver Transplantation
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20192
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