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Liver Transplantation

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https://www.readbyqxmd.com/read/29781162/predictors-of-ultrasound-failure-to-detect-hepatocellular-carcinoma
#1
Mariya L Samoylova, Neil Mehta, John P Roberts, Francis Y Yao
Current guidelines recommend ultrasound (US) for hepatocellular carcinoma (HCC) surveillance in cirrhosis. We assess predictors of decreased US sensitivity for detecting HCC. At a single U.S. center, all HCC patients evaluated for liver transplant (LT) receive an abdominal US. In consecutive patients presenting 2007-2015, untreated lesions found on CT/MRI within 3 months of US were compared with US findings. Multivariable logistic regression models compared US sensitivities by patient characteristics. Of 1008 patients completing LT evaluation, 47...
May 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29781097/aspirin-and-statin-use-for-management-of-atherosclerotic-cardiovascular-disease-in-liver-transplant-candidates-are-we-missing-the-mark
#2
EDITORIAL
Lisa B VanWagner
No abstract text is available yet for this article.
May 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29747216/survival-outcomes-in-split-compared-to-whole-liver-transplantation
#3
Kyung Chul Yoon, Sanghee Song, Eun-Kyoung Jwa, Sanghoon Lee, Jong Man Kim, Ok-Kyoung Kim, Suk Kyun Hong, Nam-Joon Yi, Kwang-Woong Lee, Myoung Soo Kim, Shin Hwang, Kyung-Suk Suh, Suk-Koo Lee
Split liver transplantation (SLT) should be cautiously considered because the right tri-sectional (RTS) graft can be a marginal graft in adult recipients. Herein, we analyzed the outcomes of RTS-SLT in Korea, where > 75% of adult liver transplantations are performed by living donor liver transplantation. Among 2,462 patients who underwent deceased donor liver transplantations (DDLT) from 2005 to 2014, we retrospectively reviewed 86 adult patients (3.4%) who received a RTS graft (RTS-SLT group). The outcomes of the RTS-SLT group were compared to those of 303 recipients of whole liver (WL-DDLT group)...
May 10, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29742806/reply-to-letter-liver-preservation-solutions-absence-of-proof-is-not-proof-of-absence
#4
LETTER
Ahmer M Hameed, Jerome M Laurence, Vincent W T Lam, Henry C Pleass, Wayne J Hawthorne
No abstract text is available yet for this article.
May 9, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29729119/palliative-care-in-end-stage-liver-disease-time-to-do-better
#5
REVIEW
Chiara Mazzarelli, Wendy M Prentice, Michael A Heneghan, Luca S Belli, Kosh Agarwal, Mary D Cannon
Optimal involvement of palliative care services in the management of patients with decompensated cirrhosis and end-stage liver disease is limited. This may result from both ignorance and the failure to recognize the spectrum and unpredictability of the underlying liver condition. Palliative care is a branch of medicine that focuses on quality of life by optimizing symptom management and providing psychosocial, spiritual, and practical support for both patients and their caregivers. Historically, palliative care has been underutilized for patients with decompensated liver disease...
May 5, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29729118/transplantation-s-cooperative-future
#6
EDITORIAL
Steven Lobritto
No abstract text is available yet for this article.
May 5, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29729113/multicenter-study-of-staging-and-therapeutic-predictors-of-hepatocellular-carcinoma-recurrence-following-transplantation
#7
Theodore H Welling, Kevin Eddinger, Kristen Carrier, Danting Zhu, Tyler Kleaveland, Derek E Moore, Douglas E Schaubel, Peter L Abt
Orthotopic liver transplantation (OLT) and resection are effective treatments for hepatocellular carcinoma (HCC). However, optimizing OLT and limiting HCC recurrence remains a vexing problem. New HCC MELD and allocation algorithms provide greater observation of HCC patients, many while receiving local-regional treatments. Potential benefits of local-regional treatment for limiting HCC recurrence post-OLT remain incompletely understood. Therefore we aimed to define HCC specific prognostic factors affecting recurrence in a contemporary, multi-center cohort of HCC patients undergoing OLT and specifically whether local-regional therapies limited recurrence...
May 5, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29729104/the-impact-of-diet-induced-hepatic-steatosis-in-a-murine-model-of-hepatic-ischemia-reperfusion-injury
#8
Kim H H Liss, Kyle S McCommis, Kari T Chambers, Terri A Pietka, George G Schweitzer, Sara L Park, ILKe Nalbantoglu, Carla J Weinheimer, Angela M Hall, Brian N Finck
The prevalence of obesity-associated nonalcoholic fatty liver disease has significantly increased over the past decade and end stage liver disease secondary to nonalcoholic steatohepatitis has become one of the most common indications for liver transplantation. This both increases the demand for organs and decreases the availability of donor livers deemed suitable for transplantation. While in the past many steatotic livers were discarded due to concerns over enhanced susceptibility to ischemia reperfusion injury and organ failure, the discrepancy between supply and demand has resulted in increasing use of expanded criteria donor organs including steatotic livers...
May 5, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29710397/is-portal-venous-pressure-modulation-still-indicated-for-all-recipients-in-living-donor-liver-transplantation
#9
Siyuan Yao, Toshimi Kaido, Ryuji Uozumi, Shintaro Yagi, Yosuke Miyachi, Ken Fukumitsu, Takayuki Anazawa, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
BACKGROUND: There is a consensus that portal venous pressure (PVP) modulation prevents portal hypertension (PHT) and consequent complications after adult living donor liver transplantation (ALDLT). However, PVP-modulation strategies need updating based on most recent findings. We examined our 10-year experience of PVP modulation and reevaluate whether it is necessary for all recipients or selected recipients in ALDLT. METHODS: In this retrospective study, 319 patients who underwent ALDLT from 2007 to 2016 were divided into three groups according to the necessity and results of PVP modulation: not indicated (n=189), indicated and successful (n=92), and indicated but failed (n=38)...
April 30, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29710388/antitumor-effect-of-sorafenib-and-mtor-inhibitor-in-liver-transplantation-recipients-with-hepatocellular-carcinoma-recurrence
#10
Dong-Hwan Jung, Eunyoung Tak, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Gil-Chun Park, Baek-Yeol Ryoo, Kyoung-Jin Lee, Nayoung Kim, Jae-Hyeon Kwon, Eun-Kyoung Jwa, Sung-Gyu Lee
Both sorafenib and mTOR inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their antitumor effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence. We performed a laboratory study using sorafenib and mTORi and subsequently validated their survival benefit at clinical LT setting. In the laboratory study, HepG2.2.15 liver tumor cell line and five patient-derived graft HCC cell lines were used for in vitro cytotoxic studies. After treatment with everolimus and sorafenib, cell viability and apoptosis assays revealed noticeable cytotoxic effects with individual agents and augmented effects by combination therapy...
April 30, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29704327/morphological-characterization-of-chronic-antibody-mediated-rejection-in-abo-identical-or-compatible-pediatric-liver-graft-recipients
#11
Myriam Dao, Dalila Habès, Jean-Luc Taupin, Charlotte Mussini, Marie-José Redon, Caroline Suberbielle, Emmanuel Jacquemin, Emmanuel Gonzales, Catherine Guettier
ASBTRACT This study aims to define the morphological profile associated with the presence of donor-specific antibodies (DSA) and/or C4d immunostaining in ABO-identical or compatible pediatric liver grafts. Ten-year protocol liver graft biopsies performed at 131.3 ± 15.3 months post-transplantation in 53 pediatric liver graft recipients were reviewed. Immunostaining for C4d was systematically performed and semi-quantitatively analyzed. DSA were concurrently quantified and results were available for 44 patients...
April 27, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29704300/can-we-minimize-waiting-list-mortality-in-young-children-with-biliary-atresia
#12
EDITORIAL
A Schlegel, P Muiesan
No abstract text is available yet for this article.
April 27, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29698577/fatigue-pain-and-other-physical-symptoms-of-living-liver-donors-in-the-adult-to-adult-living-donor-liver-transplantation-cohort-study-a2all-2
#13
Zeeshan Butt, Andrea F DiMartini, Qian Liu, Mary Ann Simpson, Abigail R Smith, Jarcy Zee, Brenda W Gillespie, Susan Holtzman, Daniela Ladner, Kim Olthoff, Robert A Fisher, Silvia Hafliger, Chris E Freise, Mercedes Susan Mandell, Averell H Sherker, Mary Amanda Dew
BACKGROUND: Little is known about living liver donors' perceptions of their physical well-being following the procedure. METHODS: We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multi-center Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL-2) Consortium. A total of 271 (91%) of 297 eligible donors were interviewed at least once at pre-donation and 3, 6, 12, and 24 months after donation using validated measures, when available...
April 26, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29694712/reply-to-letter-to-the-editor-by-patrono-et-al-lt-18-211-concerning-manuscript-normothermic-machine-perfusion-of-donor-livers-without-the-need-for-human-blood-products-lt-17-589-r2
#14
LETTER
Alix P M Matton, Yvonne de Vries, Robert J Porte
No abstract text is available yet for this article.
April 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29694710/strategies-that-reduce-90-day-readmissions-and-inpatient-costs-after-liver-transplantation
#15
Joseph H Zeidan, David M Levi, Ruth Pierce, Mark W Russo
BACKGROUND: Liver transplantation is hospital-resource intensive and associated with high rates of readmission. We have previously shown a reduction in 30-day readmission rates by implementing a specifically designed protocol to increase access to outpatient care. AIM: To determine if strategies that reduce 30-day readmission after liver transplant were effective in also reducing 90-day readmission rates and costs. METHODS: A protocol was developed to reduce inpatient readmissions after liver transplant that expanded outpatient services and provided alternatives to readmission...
April 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29694706/liver-transplantation-for-alcoholic-hepatitis-being-consistent-about-where-to-set-the-bar
#16
EDITORIAL
Mark Thursz, Michael Allison
No abstract text is available yet for this article.
April 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29694701/normothermic-machine-perfusion-of-donor-livers-without-the-need-for-human-blood-products
#17
LETTER
Damiano Patrono, Mauro Salizzoni, Renato Romagnoli
No abstract text is available yet for this article.
April 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684255/molecular-profiling-of-post-reperfusion-milieu-determines-acute-kidney-injury-after-liver-transplantation-a-prospective-study
#18
Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G Bowen, Geoffrey W McCaughan, Michael Crawford, Nicholas Shackel
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between post-reperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty-five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (RT- PCR), was performed on liver biopsies. Gene expression of 23 genes involved in ischemia reperfusion injury (IRI) was evaluated...
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29684248/celiac-axis-extension-grafts-in-orthotopic-liver-transplantation
#19
J A Geha, N T Galvan, M Kueht, D Yoeli, J D Geha, A Rana, R T Cotton, C A O'Mahony, J A Goss
No abstract text is available yet for this article.
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29679463/cdp-choline-protects-liver-from-ischemia-reperfusion-injury-preserving-mitochondrial-function-and-reducing-oxidative-stress
#20
Cecilia Zazueta, Mabel Buelna-Chontal, Arturo Macías-López, Nadia G Román-Anguiano, Héctor González-Pacheco, Natalia Pavón, Rashidi Springall, Alberto Aranda-Frausto, Rafael Bojalil, Alejandro Silva-Palacios, Rodrigo Velázquez-Espejel, Sonia Galvan Arzate, Francisco Correa
CDP-choline (citicoline) participates as intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Citicoline treatment has shown beneficial effects in cerebral ischemia, but its potential to diminish reperfusion damage in liver has not been explored. In this work, we evaluated the hepatoprotective effect of citicoline and its possible association with inflammatory/oxidative stress and mitochondrial function, as they are main cellular features of reperfusion damage...
April 20, 2018: Liver Transplantation
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