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Liver Transplantation

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https://www.readbyqxmd.com/read/28926189/environmental-peer-pressure-cd4-t-cell-help-in-tolerance-and-transplantation
#1
REVIEW
Dana Tedesco, Arash Grakoui
The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic-rich intestinal blood, oxidative stress and metabolic intermediates, there is no appreciable immune response. Interestingly, patients undergoing orthotopic liver transplantation benefit from a high rate of graft acceptance in comparison to other solid organ transplant recipients. In fact, co-transplantation of a donor liver in tandem with a rejection-prone graft increases the likelihood of graft acceptance...
September 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28926173/excellent-outcomes-in-combined-liver-kidney-transplantation-impact-of-kdpi-and-delayed-kidney-transplantation
#2
Burcin Ekser, Richard S Mangus, Chandrashekhar A Kubal, John A Powelson, Jonathan A Fridell, William C Goggins
The positive impact of delayed kidney transplantation (KT) on patient survival for combined liver-KT (CLKT) has already been demonstrated by our group. The purpose of this study is to identify whether the quality of the kidneys (based on KDPI) or the delayed approach KT contributes to improved patient survival. 130 CLKT were performed between 2002-2015; 69 with simultaneous KT (Group S) and 61 with delayed KT (Group D) (performed as a second operation with a mean cold ischemia time [CIT] of 50±15h). All patients were categorized according to the KDPI score; 1-33%, 34-66%, and 67-99%...
September 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28926171/biliary-reconstructive-techniques-and-associated-anatomic-variants-in-adult-living-donor-liver-transplants-the-a2all-experience
#3
Talia B Baker, Michael A Zimmerman, Nathan P Goodrich, Benjamin Samstein, Elizabeth A Pomfret, James J Pomposelli, Brenda W Gillespie, Carl L Berg, Jean C Emond, Robert M Merion
INTRODUCTION: Living donor liver transplantation (LDLT) is a technically demanding endeavor, requiring command of the complex anatomy of partial liver grafts. We examined the influence of anatomic variation and reconstruction technique on surgical outcomes and graft survival in the nine-center A2ALL Study. METHODS: Data from 272 adult LDLT recipients (2011-2015) included details on anatomic characteristics and types of intraoperative biliary reconstruction. Associations were tested between reconstruction technique and complications, which included first biliary complication ([BC]; leak, stricture, or biloma) and first vascular complication (hepatic artery thrombosis [HAT] or portal vein thrombosis [PVT])...
September 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28921889/the-reality-of-de-novo-malignancy-sadly-not-fake-news
#4
EDITORIAL
Manhal Izzy, Kymberly D Watt
No abstract text is available yet for this article.
September 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28921876/validation-of-artificial-neural-networks-as-a-methodology-for-donor-recipient-matching-for-liver-transplantation
#5
María Dolores Ayllón, Rubén Ciria, Manuel Cruz-Ramírez, María Pérez-Ortiz, Roberto Valente, John O'Grady, Manuel de la Mata, César Hervás-Martínez, Nigel D Heaton, Javier Briceño
BACKGROUND: In 2014, we reported a model for Donor-Recipient matching (D-R) in liver transplantation (LT) based on artificial-neural-networks (ANN) from a Spanish multicentre study (MADR-E: Model for Allocation of Donor and Recipient in España). The aim is to test the ANN-based methodology in a different European-healthcare system in order to validate it. METHODS: An ANN model was designed using a cohort of patients from King's College Hospital (KCH) (N=822). The ANN was trained and tested using KCH pairs for both 3- and 12-months survival models...
September 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28913888/viral-upper-respiratory-infection-at-pediatric-liver-transplant-is-associated-with-hepatic-artery-thrombosis
#6
Jordan A Kohler, Flor M Munoz, John A Goss, Tamir A Miloh
No abstract text is available yet for this article.
September 15, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28886231/gadoxetic-acid-enhanced-mri-outperformed-mdct-in-diagnosing-small-hepatocellular-carcinoma-a-meta-analysis
#7
Xijiao Liu, Hanyu Jiang, Jie Chen, You Zhou, Zixing Huang, Bin Song
Early detection of small hepatocellular carcinoma (HCC) lesions can improve long-term patient survival. A systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and multidetector computed tomography (MDCT) was performed in diagnosing small HCCs measuring up to 2 cm(≤2cm). Two investigators searched multiple databases for studies in which the performances of either Gd-EOB-DTPA-enhanced MRI or MDCT were reported with sufficient data to construct 2 × 2 contingency tables for diagnosing HCCs up to 2 cm on a per-lesion or per-patient level...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28885774/small-for-size-grafts-increase-recurrence-of-hepatocellular-carcinoma-in-liver-transplantation-beyond-milan-criteria
#8
Eung Chang Lee, Seong Hoon Kim, Jae Ryong Shim, Sang-Jae Park
BACKGROUND: Living donor liver transplantation (LDLT) has been reported to have high rates of hepatocellular carcinoma (HCC) recurrence compared to deceased donor liver transplant (DDLT). This has been assumed to be due to the frequent use of small-for-size grafts (SFSG) in LDLT rather than DDLT, but the relationship between graft size and prognosis remains controversial. This study aimed to clarify the effect of SFSG on the oncologic outcomes of patients with HCC who underwent LDLT. METHODS: Between January 2005 and December 2015, 597 consecutive patients underwent LDLT...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28885772/overt-hepatic-encephalopathy-impairs-learning-on-the-encephalapp-stroop-which-is-reversible-after-liver-transplant
#9
Chathur Acharya, James B Wade, Andrew Fagan, Melanie White, Edith Gavis, Dinesh Ganapathy, HoChong Gilles, Douglas M Heuman, Jasmohan S Bajaj
After an initial exposure, subjects can develop test-taking/learning strategies called the "test sophistication effect. Cirrhotics wth prior overt hepatic encephalopathy (OHE) could have persistent learning impairments. AIM: To define learning/test-sophistication on EncephalApp (downloadable Application) in OHE patients compared to no-OHE patients and controls cross-sectionally and longitudinally. METHODS: The EncephalApp Stroop App consists of 2 sections; the easier "Off" run assesses psychomotor speed while the difficult "On" run assesses cognitive flexibility...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28885771/impact-of-donor-age-in-donation-after-cardiac-death-liver-transplantation-is-the-cut-off-60-still-of-relevance
#10
Andrea Schlegel, Irene Scalera, M Thamara, P R Perera, Marit Kalisvaart, Hynek Mergental, Darius F Mirza, John Isaac, Paolo Muiesan
Background Advanced donor age has been identified as risk factor, when combined with donor warm ischemia, e.g. in donation after circulatory death (DCD). In several countries DCD livers, older than 60 years are not considered suitable due to concerns related to poor graft function and development of ischaemic cholangiopathy. We evaluate in this study outcome after DCD liver transplantation using grafts from donors older than 60 years. Methodology We analysed outcome after DCD liver transplantation (n=315), comparing donors >60 years (n=93) and donors ≤60 years (n=222) from our centre between 2005 and 2015...
September 8, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28846212/dcd-in-the-hcc-patient-same-indication
#11
Charles C Vining, Brett L Ecker, Peter L Abt, Kim M Olthoff
No abstract text is available yet for this article.
August 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28846197/reply-reconstruction-of-anomalous-portal-venous-branching-in-right-lobe-living-donor-liver-transplantation-malatya-approach
#12
LETTER
Sezai Yilmaz
No abstract text is available yet for this article.
August 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28846188/controversies-in-liver-transplantation-a-new-series-for-the-journal
#13
EDITORIAL
James F Trotter
No abstract text is available yet for this article.
August 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28846183/maximizing-donors-with-viral-hepatitis-in-the-current-era
#14
Kimberly Brown
No abstract text is available yet for this article.
August 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28846181/maximizing-allograft-function
#15
Michael R Lucey
No abstract text is available yet for this article.
August 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28837749/vaccination-to-prevent-de-novo-hepatitis-b-are-there-patients-who-don-t-need-antiviral-prophylaxis
#16
EDITORIAL
Elizabeth C Verna
No abstract text is available yet for this article.
August 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28837747/meld-exceptions-a-common-problem
#17
EDITORIAL
Joel P Wedd
No abstract text is available yet for this article.
August 24, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28834305/liver-transplant-in-patients-with-portal-vein-thrombosis-medical-and-surgical-requirements
#18
Kendra D Conzen, Elizabeth A Pomfret
No abstract text is available yet for this article.
August 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28834223/liver-and-systemic-hemodynamics-in-cirrhotic-children-impact-on-the-surgical-management-in-pediatric-living-donor-liver-transplantation
#19
Catherine de Magnée, Francis Veyckemans, Thierry Pirotte, Renaud Menten, Dana Dumitriu, Philippe Clapuyt, Karlien Carbonez, Catherine Barrea, Thierry Sluysmans, Christine Sempoux, Isabelle Leclercq, Francis Zech, Xavier Stephenne, Raymond Reding
BACKGROUND AND AIMS: Cirrhosis in adults is associated with modifications of systemic and liver hemodynamics, whereas little is known about the pediatric population. The aim of this work was to investigate whether alterations of hepatic and systemic hemodynamics were correlated with cirrhosis severity in children. The impact of hemodynamic findings on surgical management in pediatric living donor liver transplantation was evaluated. METHODS: Liver and systemic hemodynamics were studied prospectively in 52 children (median age= 1 year; 33 biliary atresia)...
August 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28834221/-tolerance-after-liver-transplantation-where-are-we
#20
REVIEW
Sandy Feng, John Bucuvalas
No abstract text is available yet for this article.
August 17, 2017: Liver Transplantation
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20192
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