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Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K

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https://www.readbyqxmd.com/read/30008477/the-mcl1-specific-inhibitor-s63845-acts-synergistically-with-venetoclax-abt-199-to-induce-apoptosis-in-t-cell-acute-lymphoblastic-leukemia-cells
#1
Zhaodong Li, Shuning He, A Thomas Look
No abstract text is available yet for this article.
July 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29985446/correction-myc-containing-amplicons-in-acute-myeloid-leukemia-genomic-structures-evolution-and-transcriptional-consequences
#2
Alberto L'Abbate, Doron Tolomeo, Ingrid Cifola, Marco Severgnini, Antonella Turchiano, Bartolomeo Augello, Gabriella Squeo, Pietro D'Addabbo, Debora Traversa, Giulia Daniele, Angelo Lonoce, Mariella Pafundi, Massimo Carella, Orazio Palumbo, Anna Dolnik, Dominique Muehlematter, Jacqueline Schoumans, Nadine Van Roy, Gianluca De Bellis, Giovanni Martinelli, Giuseppe Merla, Lars Bullinger, Claudia Haferlach, Clelia Tiziana Storlazzi
In the original version of this Article, the affiliation details for Giovanni Martinelli were incorrectly given as 'Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138, Bologna, Italy' and it should have been given as 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy and not Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138, Bologna, Italy.'Furthermore, the original version of this Article contained an error in the spelling of the authors Alberto L'Abbate and Pietro D'Addabbo, an acute accent was used instead of an apostrophe for these authors names...
July 9, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29977018/cytogenetic-abnormalities-in-monoclonal-gammopathy-of-undetermined-significance
#3
LETTER
Maximilian Merz, Thomas Hielscher, Korbinian Hoffmann, Anja Seckinger, Dirk Hose, Marc S Raab, Jens Hillengass, Anna Jauch, Hartmut Goldschmidt
No abstract text is available yet for this article.
July 6, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29977017/assay-to-rapidly-screen-for-immunoglobulin-light-chain-glycosylation-a-potential-path-to-earlier-al-diagnosis-for-a-subset-of-patients
#4
Sanjay Kumar, David Murray, Surendra Dasari, Paolo Milani, David Barnidge, Benjamin Madden, Taxiarchis Kourelis, Bonnie Arendt, Giampaolo Merlini, Marina Ramirez-Alvarado, Angela Dispenzieri
No abstract text is available yet for this article.
July 6, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29977016/genetic-predisposition-to-b-cell-acute-lymphoblastic-leukemia-at-14q11-2-is-mediated-by-a-cebpe-promoter-polymorphism
#5
James B Studd, Minjun Yang, Zhenhua Li, Jayaram Vijayakrishnan, Yi Lu, Allen Eng-Juh Yeoh, Kajsa Paulsson, Richard S Houlston
Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Genome-wide association studies have shown variation at 14q11.2 influences ALL risk. We sought to decipher causal variant(s) at 14q11.2 and the mechanism of tumorigenesis. We show rs2239630 G>A resides in the promoter of the CCAT enhancer-binding protein epsilon (CEBPE) gene. The rs2239630-A risk allele is associated with increased promotor activity and CEBPE expression. Depletion of CEBPE in ALL cells reduces cell growth, correspondingly CEBPE binds to the promoters of electron transport and energy generation genes...
July 6, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29977015/time-resolved-quantitative-phospho-tyrosine-analysis-reveals-bruton-s-tyrosine-kinase-mediated-signaling-downstream-of-the-mutated-granulocyte-colony-stimulating-factor-receptors
#6
Pankaj Dwivedi, David E Muench, Michael Wagner, Mohammad Azam, H Leighton Grimes, Kenneth D Greis
Granulocyte-colony stimulating factor receptor (G-CSFR) controls myeloid progenitor proliferation and differentiation to neutrophils. Mutations in CSF3R (encoding G-CSFR) have been reported in patients with chronic neutrophilic leukemia (CNL) and acute myeloid leukemia (AML); however, despite years of research, the malignant downstream signaling of the mutated G-CSFRs is not well understood. Here, we used a quantitative phospho-tyrosine analysis to generate a comprehensive signaling map of G-CSF induced tyrosine phosphorylation in the normal versus mutated (proximal: T618I and truncated: Q741x) G-CSFRs...
July 5, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29967380/modeling-asxl1-mutation-revealed-impaired-hematopoiesis-caused-by-derepression-of-p16ink4a-through-aberrant-prc1-mediated-histone-modification
#7
Masahiro Uni, Yosuke Masamoto, Tomohiko Sato, Yasuhiko Kamikubo, Shunya Arai, Eiji Hara, Mineo Kurokawa
In spite of distinct clinical importance, the molecular mechanisms how Additional sex combs-like 1 (ASXL1) mutation contributes to the pathogenesis of premalignant conditions are largely unknown. Here, with newly generated knock-in mice, we investigated the biological effects of the mutant. Asxl1G643fs heterozygous (Asxl1G643fs/+ ) mice developed phenotypes recapitulating human low-risk myelodysplastic syndromes (MDS), and some of them developed MDS/myeloproliferative neoplasm-like disease after long latency...
July 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29967379/a-high-risk-double-hit-group-of-newly-diagnosed-myeloma-identified-by-genomic-analysis
#8
Brian A Walker, Konstantinos Mavrommatis, Christopher P Wardell, T Cody Ashby, Michael Bauer, Faith Davies, Adam Rosenthal, Hongwei Wang, Pingping Qu, Antje Hoering, Mehmet Samur, Fadi Towfic, Maria Ortiz, Erin Flynt, Zhinuan Yu, Zhihong Yang, Dan Rozelle, John Obenauer, Matthew Trotter, Daniel Auclair, Jonathan Keats, Niccolo Bolli, Mariateresa Fulciniti, Raphael Szalat, Phillipe Moreau, Brian Durie, A Keith Stewart, Hartmut Goldschmidt, Marc S Raab, Hermann Einsele, Pieter Sonneveld, Jesus San Miguel, Sagar Lonial, Graham H Jackson, Kenneth C Anderson, Herve Avet-Loiseau, Nikhil Munshi, Anjan Thakurta, Gareth Morgan
Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene expression features have been used to identify high-risk patients, each of which has significant weaknesses. Inclusion of molecular features into risk stratification could resolve the current challenges. In a genome-wide analysis of the largest set of molecular and clinical data established to date from NDMM, as part of the Myeloma Genome Project, we have defined DNA drivers of aggressive clinical behavior...
July 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29967378/whole-exome-sequencing-exploration-of-acquired-uniparental-disomies-in-b-cell-precursor-acute-lymphoblastic-leukemia
#9
Kristina B Lundin-Ström, Andrea Biloglav, Henrik Lilljebjörn, Marianne Rissler, Thoas Fioretos, Markus Hansson, Mikael Behrendtz, Anders Castor, Linda Olsson, Bertil Johansson
No abstract text is available yet for this article.
July 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29967377/diplotype-analysis-of-nudt15-variants-and-6-mercaptopurine-sensitivity-in-pediatric-lymphoid-neoplasms
#10
Shinichi Tsujimoto, Tomoo Osumi, Meri Uchiyama, Ryota Shirai, Takaya Moriyama, Rina Nishii, Yuji Yamada, Ko Kudo, Masahiro Sekiguchi, Yuki Arakawa, Masanori Yoshida, Toru Uchiyama, Kiminori Terui, Shuichi Ito, Katsuyoshi Koh, Junko Takita, Etsuro Ito, Daisuke Tomizawa, Atsushi Manabe, Nobutaka Kiyokawa, Jun J Yang, Motohiro Kato
No abstract text is available yet for this article.
July 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29959415/a-non-myeloablative-conditioning-approach-for-long-term-engraftment-of-human-and-mouse-hematopoietic-stem-cells
#11
Wei Du, Wei Liu, Benjamin Mizukawa, Xun Shang, Jared Sipple, Mark Wunderlich, Hartmut Geiger, Stella Davies, James Mulloy, Qishen Pang, Yi Zheng
No abstract text is available yet for this article.
June 29, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29959414/discriminating-a-common-somatic-asxl1-mutation-c-1934dup-p-g646wfs-12-from-artifact-in-myeloid-malignancies-using-ngs
#12
Michael O Alberti, Sridhar Nonavinkere Srivatsan, Jin Shao, Samantha N McNulty, Gue Su Chang, Christopher A Miller, Jennifer B Dunlap, Fei Yang, Richard D Press, Qingsong Gao, Li Ding, Jonathan W Heusel, Eric J Duncavage, Matthew J Walter
No abstract text is available yet for this article.
June 29, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29959413/bortezomib-based-induction-therapy-with-high-or-low-dose-dexamethasone-in-newly-diagnosed-transplant-eligible-multiple-myeloma
#13
Elias K Mai, Thomas Hielscher, Uta Bertsch, Jana Schlenzka, Hans J Salwender, Markus Munder, Christian Gerecke, Ulrich Dührsen, Peter Brossart, Kai Neben, Jens Hillengass, Marc S Raab, Maximilian Merz, Marc-Andrea Baertsch, Anna Jauch, Dirk Hose, Hans Martin, Hans-Walter Lindemann, Igor W Blau, Christof Scheid, Katja C Weisel, Hartmut Goldschmidt
No abstract text is available yet for this article.
June 29, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29955132/an-mds-derived-cell-line-and-a-series-of-its-sublines-serve-as-an-in-vitro-model-for-the-leukemic-evolution-of-mds
#14
Jun-Ichiro Kida, Takayuki Tsujioka, Shin-Ichiro Suemori, Shuichiro Okamoto, Kanae Sakakibara, Takayuki Takahata, Takahiro Yamauchi, Akira Kitanaka, Yumi Tohyama, Kaoru Tohyama
No abstract text is available yet for this article.
June 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29955131/dnmt1-links-bcr-ablp210-to-epigenetic-tumor-stem-cell-priming-in-myeloid-leukemia
#15
Carolina Vicente-Dueñas, Inés González-Herrero, Lalit Sehgal, Idoia García-Ramírez, Guillermo Rodríguez-Hernández, Belén Pintado, Oscar Blanco, Francisco Javier García Criado, María Begoña García Cenador, Michael R Green, Isidro Sánchez-García
No abstract text is available yet for this article.
June 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29955130/lrpap1-is-a-frequent-proliferation-inducing-antigen-of-bcrs-of-mantle-cell-lymphomas-and-can-be-used-for-specific-therapeutic-targeting
#16
Lorenz Thurner, Sylvia Hartmann, Natalie Fadle, Maria Kemele, Theresa Bock, Moritz Bewarder, Evi Regitz, Frank Neumann, Anna Nimmesgern, Lutz von Müller, Christiane Pott, Yoo-Jin Kim, Rainer Maria Bohle, Mariusz Wasik, Stephen J Schuster, Martin-Leo Hansmann, Klaus-Dieter Preuss, Michael Pfreundschuh
The predominant usage of VH4-34 and V3-21 and reports of stereotyped CDR3s suggest a shared antigenic target of B-cell receptors (BCR) from mantle cell lymphomas (MCL). To identify the target antigens of MCL-BCRs, BCRs from 21 patients and seven MCL cell lines were recombinantly expressed and used for antigen screening. The BCRs from 8/21 patients and 2/7 MCL cell lines reacted specifically with the autoantigen low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1). High-titered and light chain-restricted anti-LRPAP1 serum antibodies were found in MCL patients, but not in controls...
June 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29955129/so-called-blast-phase-of-chronic-myelomonocytic-leukemia-a-plea-for-uniform-terminology
#17
LETTER
Elizabeth Margolskee
No abstract text is available yet for this article.
June 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29955128/evidence-and-consensus-based-recommendations-for-phlebotomy-in-polycythemia-vera
#18
Tiziano Barbui, Francesco Passamonti, Patrizia Accorsi, Fabrizio Pane, Alessandro M Vannucchi, Claudio Velati, Robert P Gale, Sante Tura, Giovanni Barosi
No abstract text is available yet for this article.
June 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29950694/polycomb-repressive-complex-2-haploinsufficiency-identifies-a-high-risk-subgroup-of-pediatric-acute-myeloid-leukemia
#19
Jonathan Bond, Elise Labis, Alice Marceau-Renaut, Nicolas Duployez, Myriam Labopin, Guillaume Hypolite, Gérard Michel, Stéphane Ducassou, Hélène Boutroux, Brigitte Nelken, Yves Bertrand, André Baruchel, Arnaud Petit, Vahid Asnafi, Guy Leverger, Claude Preudhomme, Elizabeth Macintyre, Hélène Lapillonne
No abstract text is available yet for this article.
June 27, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29950693/a-prospective-study-on-serum-cytokeratin-ck-18-and-ck18-fragments-as-biomarkers-of-acute-hepato-intestinal-gvhd
#20
Sandra Sauer, Johannes Hüsing, Jacek Hajda, Frank Neumann, Aleksandar Radujkovic, Anthony D Ho, Peter Dreger, Thomas Luft
Apoptotic intestinal crypt cells are pathognomonic of acute intestinal graft versus host disease (GVHD). Serum levels of the apoptotic degradation product cytokeratin-18 fragments (CK18F) were associated with acute hepato-intestinal GVHD. Here we present a prospective clinical observational trial (NCT00935324) investigating serum levels of total CK18 (tCK18) and apoptotic CK18F to predict imminent acute hepato-intestinal GVHD and response to treatment. Total (t)CK18 and CK18F kinetics were measured before transplantation and in weekly intervals thereafter...
June 27, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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