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Laryngoscope

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https://www.readbyqxmd.com/read/29226485/immunohistologic-analysis-of-spontaneous-recurrent-laryngeal-nerve-reinnervation-in-a-rat-model
#1
Andrew J Rosko, Robbi A Kupfer, Sang S Oh, Catherine T Haring, Eva L Feldman, Norman D Hogikyan
OBJECTIVE: After recurrent laryngeal nerve injury (RLN), spontaneous reinnervation of the larynx occurs with input from multiple sources. The purpose of this study was to determine the timing and efficiency of reinnervation across a resected RLN segment in a rat model of RLN injury. STUDY DESIGN: Animal study. METHODS: Twelve male 60-day-old Sprague Dawley rats underwent resection of a 5-mm segment of the right RLN. Rats were sacrificed at 1, 2, 4, and 12 weeks after nerve injury to harvest the larynx and trachea for immunohistologic analysis...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29226334/early-stage-olfactory-neuroblastoma-and-the-impact-of-resecting-dura-and-olfactory-bulb
#2
Ashley C Mays, Diana Bell, Renata Ferrarotto, Jack Phan, Dianna Roberts, Clifton D Fuller, Steven J Frank, Shaan M Raza, Michael E Kupferman, Franco DeMonte, Ehab Y Hanna, Shirley Y Su
OBJECTIVE: Compare outcomes of patients with olfactory neuroblastoma (ONB) without skull base involvement treated with and without resection of the dura and olfactory bulb. METHODS: Retrospective review of ONB patients treated from 1992 to 2013 at the MD Anderson Cancer Center (The University of Texas, Houston, Texas, U.S.A.). Primary outcomes were overall and disease-free survival. RESULTS: Thirty-five patients were identified. Most patients had Kadish A/B...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29226330/transcutaneous-immunization-with-pneumococcal-surface-protein-a-in-mice
#3
Hiromi Nagano, Masaki Kawabata, Gen Sugita, Akitoshi Tsuruhara, Junichiro Ohori, Tomohiro Jimura, Keiichi Miyashita, Yuichi Kurono, Kazuhiro Tomonaga, David E Briles, Kohtaro Fujihashi
OBJECTIVE: Pneumococcal infection caused by Streptococcus pneumoniae is a major upper respiratory tract disease that causes severe illness and mortality. Therefore, it is important to develop safe and effective vaccines to prevent pneumococcal infections. The goal of the study was to investigate the effectiveness of transcutaneous immunization (TCI) for induction of pneumococcal surface protein A (PspA) responses in the upper respiratory tract. METHODS: C57BL/6 mice were transcutaneously immunized with 1 μg of PspA and 2 μg of cholera toxin (CT) six times at weekly intervals and compared with transcutaneously treated controls (PBS alone/PspA alone/CT alone)...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29226324/tandem-walking-as-a-quick-screening-test-for-vestibular-disorders
#4
Helen S Cohen, Jasmine Stitz, Haleh Sangi-Haghpeykar, Susan P Williams, Ajitkumar P Mulavara, Brian T Peters, Jacob J Bloomberg
OBJECTIVES/HYPOTHESIS: Although many screening tests of balance are available, few of them have been well validated for clinical or research uses. The goal of this study was to test an updated version of an old test, Tandem Walking, to determine how useful it is for screening patients with vestibular disorders. STUDY DESIGN: Case-control study. METHODS: Subjects were 90 adult patients with vestibular disorders and 292 healthy adult controls...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219192/what-is-the-appropriate-timing-for-endoscopic-and-radiographic-surveillance-following-treatment-for-sinonasal-malignancies
#5
Arjun K Parasher, Edward C Kuan, Maie A St John, Bobby A Tajudeen, Nithin D Adappa
No abstract text is available yet for this article.
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219191/the-development-of-the-human-hyoid-larynx-complex-revisited
#6
Bernadette S de Bakker, Henri M de Bakker, Vidija Soerdjbalie-Maikoe, Frederik G Dikkers
OBJECTIVES/HYPOTHESIS: The hyoid-larynx complex is highly prone to anatomical variation. The etiology of anatomical variants such as Eagle's syndrome and the aberrant hyoid apparatus can be explained from embryonic development. Modern textbooks state that the hyoid bone body develops from the second and third pharyngeal arch cartilages, and that thyroid cartilage derives from the fourth and sixth arch cartilages. This description, however, is incompatible with various anatomical variants, and it is unclear whether it was based on observations in human embryos or on comparative embryology...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219190/phenomenology-genetics-and-cns-network-abnormalities-in-laryngeal-dystonia-a-30-year-experience
#7
Andrew Blitzer, Mitchell F Brin, Kristina Simonyan, Laurie J Ozelius, Steven J Frucht
OBJECTIVE: Laryngeal dystonia (LD) is a functionally specific disorder of the afferent-efferent motor coordination system producing action-induced muscle contraction with a varied phenomenology. This report of long-term studies aims to review and better define the phenomenology and central nervous system abnormalities of this disorder and improve diagnosis and treatment. METHODS: Our studies categorized over 1,400 patients diagnosed with LD over the past 33 years, including demographic and medical history records and their phenomenological presentations...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219188/toxicity-trial-of-canine-posterior-cricoarytenoid-intramuscular-vincristine-injections
#8
Randal C Paniello, Neel K Bhatt, Rebecca Chernock
OBJECTIVES/HYPOTHESIS: In animal studies, intramuscular vincristine injections have been shown to block reinnervation of the denervated target muscle. This application could be used selectively to influence recovery patterns following injury of recurrent laryngeal nerves (RLNs). However, vincristine is currently Food and Drug Administration approved only for intravenous use. A formal toxicity trial of intramuscular injections was performed. STUDY DESIGN: Animal study...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219186/improved-adductor-function-after-canine-recurrent-laryngeal-nerve-injury-and-repair-using-muscle-progenitor-cells
#9
Randal C Paniello, Sarah Brookes, Neel K Bhatt, Khadijeh Bijangi-Vishehsaraei, Hongji Zhang, Stacey Halum
OBJECTIVE: Muscle progenitor cells (MPCs) can be isolated from muscle samples and grown to a critical mass in culture. They have been shown to survive and integrate when implanted into rat laryngeal muscles. In this study, the ability of MPC implants to enhance adductor function of reinnervated thyroarytenoid muscles was tested in a canine model. STUDY DESIGN: Animal study. METHODS: Sternocleidomastoid muscle samples were harvested from three canines...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219185/the-development-and-validation-of-the-speech-quality-instrument
#10
Stephanie Y Chen, Brianna M Griffin, Dean Mancuso, Stephanie Shiau, Michelle DiMattia, Ilana Cellum, Kelly Harvey Boyd, Charlotte Prevoteau, Gavriel D Kohlberg, Jaclyn B Spitzer, Anil K Lalwani
OBJECTIVE: Although speech perception tests are available to evaluate hearing, there is no standardized validated tool to quantify speech quality. The objective of this study is to develop a validated tool to measure quality of speech heard. STUDY DESIGN: Prospective instrument validation study of 35 normal hearing adults recruited at a tertiary referral center. METHODS: Participants listened to 44 speech clips of male/female voices reciting the Rainbow Passage...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29219184/minimal-clinically-important-difference-of-voice-handicap-index-10-in-vocal-fold-paralysis
#11
VyVy N Young, Kwonho Jeong, Scott D Rothenberger, Amanda I Gillespie, Libby J Smith, Jackie L Gartner-Schmidt, Clark A Rosen
OBJECTIVES/HYPOTHESIS: The Voice Handicap Index-10 (VHI-10) is commonly used to measure patients' perception of vocal handicap. Clinical consensus has previously defined clinically meaningful improvement as a decrease ≥5. This study determines the minimal clinically important difference (MCID) for VHI-10 in patients with unilateral vocal fold paralysis (UVFP) using anchor-based methodology. STUDY DESIGN: Prospective cohort questionnaire analysis. METHODS: Two hundred eighty-one UVFP patients completed the VHI-10 on two consecutive visits (within 3 months)...
December 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29214646/endoscopic-sentinel-lymph-node-biopsy-using-indocyanine-green-neomannosyl-human-serum-albumin
#12
Young Min Park, Yu Hua Quan, Ki Hyeok Kwon, Jae-Gu Cho, Jeong-Soo Woo, Beop-Min Kim, Yun-Sang Lee, Jae Min Jeong, Hyun Koo Kim, Jae-Jun Song
OBJECTIVE: The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS). METHODS: Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope. RESULTS: ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3)...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29214641/an-app-to-enhance-resident-education-in-otolaryngology
#13
Wayne D Hsueh, John P Bent, Howard S Moskowitz
OBJECTIVE: Technological change is leading to an evolution in medical education. The objective of our study was to assess the impact of a medical knowledge app, called PulseQD, on resident education within our otolaryngology-head and neck surgery department at Montefiore Medical Center, Albert Einstein College of Medicine (Bronx, NY). METHODS: A prospective cohort study was conducted within the Department of Otolaryngology-Head and Neck Surgery from July 2016 to June 2017...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29214640/management-of-head-and-neck-primary-unknown-squamous-cell-carcinoma-using-combined-positron-emission-tomography-computed-tomography-and-transoral-laser-microsurgery
#14
Victoria Kuta, Blair Williams, Matthew Rigby, Robert Hart, Jonathan Trites, Colin MacKay, S Mark Taylor
OBJECTIVES/HYPOTHESIS: The unknown primary of the neck is commonly encountered by the head and neck surgeon. Despite the exhaustive diagnostic tools employed in traditional detection protocols, many unknown primaries are not found, and the patient is subjected to wide-field radiation and chemotherapy during treatment. Localizing the primary tumor has demonstrated therapeutic benefits, improved quality of life, and overall survival. The authors' objective was to determine the efficacy of a new management protocol for unknown primaries of the head and neck...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29214634/a-case-of-hypoglossal-nerve-stimulator-resistant-obstructive-sleep-apnea-cured-with-the-addition-of-a-chin-strap
#15
Apoorva T Ramaswamy, Carol Li, Maria V Suurna
A population of appropriately selected patients does not respond, or does not achieve cure, with hypoglossal nerve stimulation (HGNS). We describe the case of nonresponder whose obstructive sleep apnea (OSA) resolved with the addition of chin strap. After initial placement and titration of HGNS implant, follow-up sleep study demonstrated persistent moderate OSA. Drug-induced sleep endoscopy demonstrated supraglottic collapse with activate neurostimulation. With mouth closure and change of stimulation settings to unipolar from bipolar, the airway collapse and desaturations improved...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29205391/association-of-palatine-tonsil-size-and-obstructive-sleep-apnea-in-adults
#16
Sebastian M Jara, Edward M Weaver
OBJECTIVE: The relationship between palatine tonsil (PT) size and obstructive sleep apnea (OSA) has not been well established in adults. The purpose of this study was to test the association between PT grade, PT volume, and OSA severity in U.S. adult patients. STUDY DESIGN: Cross-sectional study of all patients (age ≥ 18 years) who underwent pharyngeal surgery for OSA that included palatine tonsillectomy with tonsil volume measurement from January 2011 to June 2016...
December 5, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29193191/treatment-of-tracheoesophageal-fistula-after-laryngectomy-by-a-customized-tracheal-prosthesis
#17
Simon Andreas Mueller, Sylvia Dehnbostel, Falk Dehnbostel, Roland Giger
No abstract text is available yet for this article.
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29193138/intranasal-immunization-with-phosphorylcholine-suppresses-allergic-rhinitis-in-mice
#18
Keiichi Miyashita, Junichiro Ohori, Hiromi Nagano, Satoshi Fukuyama, Yuichi Kurono
OBJECTIVES/HYPOTHESIS: Intranasal immunization with phosphorylcholine (PC) is known to reduce immunoglobulin (Ig)E production. However, its effects on the occurrence of allergic rhinitis (AR) are unknown. This study was performed to evaluate the effects of PC-keyhole limpet hemocyanin (PC-KLH) and to examine the effects on the occurrence of AR in a murine model of AR. STUDY DESIGN: In vivo study using an animal model. METHODS: Forty-five female BALB/c mice were divided into three groups; those pretreated with intranasal administration of PC-KLH followed by intraperitoneal sensitization and nasal challenge with ovalbumin (OVA) (group A), those untreated with PC-KLH followed by sensitization and nasal challenge with OVA (group B), and those untreated with PC-KLH or OVA as controls (group C)...
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29193120/the-role-of-elective-neck-dissection-in-the-treatment-of-maxillary-sinus-squamous-cell-carcinoma
#19
Neel R Sangal, Yung-Jae Lee, Jacob S Brady, Tapan D Patel, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVE: This study is designed to analyze the survival benefits of elective neck dissection (END) in the treatment of squamous cell carcinoma of the maxillary sinus (MS-SCC) with clinically negative neck lymph nodes (N0) and no metastasis (M0). STUDY DESIGN: The aim of this study was to evaluate whether END improves survival in patients with MS-SCC. METHODS: This study is a population-based, concurrent retrospective database analysis of patients diagnosed with N0M0 MS-SCC from 2004 to 2013...
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29193112/prevalence-of-adult-unilateral-hearing-loss-and-hearing-aid-use-in-the-united-states
#20
Justin S Golub, Frank R Lin, Lawrence R Lustig, Anil K Lalwani
OBJECTIVE: The prevalence of unilateral hearing loss (UHL) in adults has not been well characterized. The objectives of this study are to determine the prevalence of UHL in U.S. adults and its treatment with hearing aids using a nationally representative study. STUDY DESIGN: Cross-sectional national epidemiologic study (n = 6,242). METHODS: Subjects ≥ 18 years old with audiometric testing in the 2005 to 2006, 2009 to 2010, and 2011 to 2012 cycles of the National Health and Nutrition Examination Study were included...
November 29, 2017: Laryngoscope
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