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Laryngoscope

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https://www.readbyqxmd.com/read/29451965/pazopanib-effective-for-bevacizumab-unresponsive-epistaxis-in-hereditary-hemorrhagic-telangiectasia
#1
Joseph G Parambil, Troy D Woodard, Omer N Koc
Hereditary hemorrhagic telangiectasia (HHT) most commonly manifests with nasal mucosal telangiectasias, and vascular endothelial growth factor (VEGF) plays a significant role in this angiodysplasia. We describe a patient with HHT with epistaxis recalcitrant to several endonasal procedures and six cycles of intravenous bevacizumab, for which he was dependent on iron infusions and packed red blood cells transfusions. He then started pazopanib at 100 mg with dramatic improvements in epistaxis and normalization of hemoglobin and iron levels, without replenishment needs for 12 months...
February 16, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29451964/a-long-term-comparative-prospective-study-between-reinnervation-and-injection-laryngoplasty
#2
SeungWon Lee, KiNam Park
OBJECTIVES: This study compared and assessed long-term voice outcomes when thyroidectomy-related unilateral vocal fold paralysis (VFP) was managed using injection laryngoplasty (IL) and recurrent laryngeal nerve reinnervation (RLNR). STUDY DESIGN: Prospective clinical study. METHODS: A prospective clinical trial was performed from March 2005 to January 2016 at Soonchunhyang University Bucheon Hospital (Bucheon, South Korea). Nineteen patients who underwent ansa cervicalis to RLNR or direct reinnervation, and 43 patients who underwent IL to treat thyroidectomy-related unilateral VFP, were enrolled...
February 16, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29447427/vestibulo-ocular-reflex-gain-values-in-the-suppression-head-impulse-test-of-healthy-subjects
#3
Jorge Rey-Martinez, Izaskun Thomas-Arrizabalaga, Juan Manuel Espinosa-Sanchez, Angel Batuecas-Caletrio, Gabriel Trinidad-Ruiz, Eusebi Matiño-Soler, Nicolas Perez-Fernandez
OBJECTIVE: To assess whether there are differences in vestibulo-ocular reflex (VOR) gain for suppression head impulse (SHIMP) and head impulse (HIMP) video head impulse test paradigms, and if so, what are their causes. METHODS: Prospective multicenter observational double-blind nonrandomized clinical study was performed by collecting 80 healthy subjects from four reference hospitals. SHIMP data was postprocessed to eliminate impulses in which early SHIMP saccades were detected...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29446458/clinical-criteria-for-ct-scan-evaluation-of-upper-digestive-tract-fishbone
#4
Forsan Jahshan, Eyal Sela, Eli Layous, Einat Levy, Niddal Assadi, Etgar Shilo, Nour Ibrahim, Dor Maayan, Ohad Ronen
OBJECTIVES: To establish clinical criteria for performing computed tomography scan for suspected upper digestive tract fishbone. METHODS: This is a prospective study of all adult patients referred to the otolaryngology emergency department at our medical center for suspected fishbone in the upper digestive tract after no fishbone was seen on physical examination. The patients were divided into two groups: 1) The first was a high clinical suspicion group, which included patients with at least one of the following criteria: drooling, accumulation of saliva in the sinus piriformis, fever, referral 24 hours after the ingestion with worsening/continuing symptoms, and readmission...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29446455/uncultivated-stromal-vascular-fraction-is-equivalent-to-adipose-derived-stem-and-stromal-cells-on-porous-polyurethrane-scaffolds-forming-adipose-tissue-in-vivo
#5
Michael Griessl, Anna-Maria Buchberger, Sybille Regn, Kilian Kreutzer, Katharina Storck
OBJECTIVES/HYPOTHESIS: To find an alternative approach to contemporary techniques in tissue augmentation and reconstruction, tissue engineering strategies aim to involve adipose-derived stem and stromal cells (ASCs) harboring a strong differentiation potential into various tissue types such as bone, cartilage, and fat. STUDY DESIGN: Animal research. METHODS: The stromal vascular fraction (SVF) was used directly as a cell source to provide a potential alternative to contemporary ASC-based adipose tissue engineering...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29446449/opioid-prescribing-patterns-among-otolaryngologists-crucial-insights-among-the-medicare-population
#6
Peter F Svider, Khashayar Arianpour, Eric Guo, Elana Folbe, Giancarlo Zuliani, Hosheng Lin, Jean Anderson Eloy, Adam J Folbe
OBJECTIVES/HYPOTHESIS: There has been growing recognition of the roles prescription drug misuse and diversion play in facilitating the ongoing opioid epidemic. Our objective was to evaluate opioid prescription patterns among practicing otolaryngologists. STUDY DESIGN: Retrospective review of a CMS database. METHODS: Medicare Part D beneficiary data (2015) were accessed for a list of otolaryngologists. Opioid prescription rates, amount, and supply were calculated...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29446446/telemedicine-in-otolaryngology-outpatient-setting-single-center-head-and-neck-surgery-experience
#7
Ryan A Rimmer, Vanessa Christopher, Ailsa Falck, Edmund de Azevedo Pribitkin, Joseph M Curry, Adam J Luginbuhl, David M Cognetti
OBJECTIVES/HYPOTHESIS: We present our experience with telemedicine visits in an otolaryngology outpatient setting within our institution's Center for Head and Neck Surgery. STUDY DESIGN: Retrospective chart review. METHODS: A review of telemedicine outpatient encounters examining patient demographics, visit type, and wait times was conducted. Internet-based navigation applications were used to calculate travel distance and estimate commute time to our clinic...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29446087/open-access-is-there-a-predator-at-the-door
#8
EDITORIAL
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29427388/reviewing-smokeless-tobacco-epidemiology-carcinogenesis-and-cessation-strategy-for-otolaryngologists
#9
REVIEW
Luke Stanisce, Kristin Levin, Nadir Ahmad, Yekaterina Koshkareva
OBJECTIVES/OBJECTIVES: We aimed to provide an otolaryngologist-targeted summary regarding the epidemiology, carcinogenesis, and cessation strategies for smokeless tobacco usage. STUDY DESIGN: Evidence-based literature review. METHODS: We reviewed the current evidence-based literature concerning trends in smokeless tobacco use, associations with neoplastic change, and therapeutic interventions to assist with sustained abstinence. In complement, we present an actual case of laryngeal squamous cell carcinoma in the setting of chronic tobacco-dentifrice usage in a lifelong nonsmoker...
February 10, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29427378/dural-recurrence-among-esthesioneuroblastoma-patients-presenting-with-intracranial-extension
#10
Yao Yu, Ivan H El-Sayed, Michael W McDermott, Philip V Theodosopoulos, Annemieke van Zante, Norbert Kased, Christine M Glastonbury, Adam A Garsa, Sue S Yom
OBJECTIVE: To quantify the rate of late intracranial recurrences among esthesioneuroblastoma patients treated with surgical resection and postoperative radiation. STUDY DESIGN: Retrospective review. METHODS: All patients receiving definitive-intent therapy for esthesioneuroblastoma between March 1995 and September 2015 were reviewed. Presenting disease extent was categorized based on radiologic, operative, and pathologic findings. Between-group survival differences were assessed using Kaplan-Meier method and log-rank test...
February 10, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29417586/office-based-esophageal-dilation-in-head-and-neck-cancer-safety-feasibility-and-cost-analysis
#11
Rebecca J Howell, Melissa A Schopper, John Paul Giliberto, Ryan M Collar, Sid M Khosla
OBJECTIVE: To review experience, safety, and cost of office-based esophageal dilation in patients with history of head and neck cancer (HNCA). METHODS: The medical records of patients undergoing esophageal dilation in the office were retrospectively reviewed between August 2015 and May 2017. Patients were given nasal topical anesthesia. Next, a transnasal esophagoscopy (TNE) was performed. If the patient tolerated TNE, we proceeded with esophageal dilation using Seldinger technique with the CRE™ Boston Scientific (Boston Scientific Corp...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29417583/the-use-of-specific-immunoglobulin-e-in-nasal-secretions-for-the-diagnosis-of-allergic-rhinitis
#12
Yifan Meng, Hongfei Lou, Yang Wang, Chengshuo Wang, Luo Zhang
OBJECTIVE: Although local specific immunoglobulin (sIgE) has been employed as a diagnostic criterion for allergic rhinitis (AR), the use of local sIgE has not been fully evaluated in the diagnosis of allergic rhinitis. The aim of this study was to evaluate the use of nasal secretion sIgE in the diagnosis of allergic rhinitis. METHODS: A total of 51 patients (27 males and 24 females, mean age = 33.3 years) with rhinitis symptoms were enrolled consecutively from the allergy-rhinology clinic of Beijing TongRen Hospital (Beijing, People's Republic of China)...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29417576/olfactory-and-middle-meatal-cytokine-levels-correlate-with-olfactory-function-in-chronic-rhinosinusitis
#13
Jeffanie Wu, Rakesh K Chandra, Ping Li, Benjamin P Hull, Justin H Turner
OBJECTIVES/HYPOTHESIS: The etiology of chronic rhinosinusitis (CRS)-associated olfactory loss is unclear, but may result from inflammatory changes in the olfactory epithelium that result in signaling dysfunction or loss of olfactory neurons. Several proinflammatory cytokines have been associated with CRS, but their expression within the olfactory cleft microenvironment and association with olfactory function is unknown. STUDY DESIGN: Prospective case-control study...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29417575/patient-and-surgeon-factors-explain-variation-in-the-frequency-of-frontal-sinus-surgery
#14
Christian P Soneru, Jayant M Pinto
OBJECTIVES/HYPOTHESIS: Ethmoidectomy may be sufficient to address frontal sinus disease, but some surgeons may perform frontal recess dissection initially. Our objectives were to describe patient-associated factors with frequency of frontal sinus surgery and analyze the association with provider volume. STUDY DESIGN: Retrospective cohort analysis. METHODS: The 2013 State Ambulatory Surgery Databases of New Jersey, Florida, and Kentucky were queried to identify adults who underwent anterior ethmoidectomy or total ethmoidectomy using standard Current Procedural Terminology codes...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29405309/aspirin-does-not-prevent-growth-of-vestibular-schwannomas-a-case-control-study
#15
Samuel MacKeith, Joseph Wasson, Charlotte Baker, Matthew Guilfoyle, Deepa John, Neil Donnelly, Richard Mannion, Sarah Jefferies, Patrick Axon, James R Tysome
OBJECTIVES/HYPOTHESIS: To determine if aspirin intake is associated with reduced growth of vestibular schwannomas (VS). To determine the prevalence of contraindications to regular aspirin in patients with VS. STUDY DESIGN: Retrospective, observational case-control study. METHODS: The study utilized a postal questionnaire and telephone interviews to determine aspirin exposure. Propensity score matching was used to control for age, sex, and tumor size...
February 6, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29399802/stem-cells-enhance-reperfusion-following-ischemia-validation-using-laser-speckle-imaging-in-predicting-tissue-repair
#16
Ya Hui Tang, R Will Thompson, Cherie-Ann Nathan, Jonathan Steven Alexander, Timothy Lian
OBJECTIVES: The lack of real-time assessment of vascular perfusion changes remains a major weakness in assessing the efficacy of bone marrow stromal cells (BMSC) therapeutic ischemia reperfusion (I/R) injury. This study provides for the first time the real-time in vivo perfusion monitoring in I/R mice with BMSC therapy. STUDY DESIGN: Animal model. METHODS: Surgically created cutaneous flaps perfused by the inferior epigastric vessels were subjected to 3...
February 5, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29399801/the-potential-role-of-bile-acids-in-acquired-laryngotracheal-stenosis
#17
Adil Aldhahrani, Jason Powell, Shameem Ladak, Mahmoud Ali, Simi Ali, Bernard Verdon, Jeffrey Pearson, Chris Ward
OBJECTIVE: Gastroesophageal reflux is thought to be a risk factor for laryngotracheal stenosis. Bile acids are a component of gastric refluxate and have previously been implicated in the development of fibrosis in other airway subsites. There is clear evidence that bile acids reflux into the upper airway. We therefore investigated the potential role of bile acids in the pathophysiology of laryngotracheal fibrosis and stenosis, specifically investigating the highly conserved process of epithelial-mesenchymal transition (EMT)...
February 5, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29399800/double-blind-placebo-controlled-study-with-alginate-suspension-for-laryngopharyngeal-reflux-disease
#18
Wen-Hsuan Tseng, Ping-Huei Tseng, Jia-Feng Wu, Ya-Chin Hsu, Ting-Yi Lee, Yen-Hsuan Ni, Hsiu-Po Wang, Tzu-Yu Hsiao, Wei-Chung Hsu
OBJECTIVE: Treatment for laryngopharyngeal reflux disease (LPRD) is challenging because of delays in recognition and poor responsiveness to proton-pump inhibitor therapy. The aim of this study was to determine the efficacy and safety of liquid alginate suspension for treating LPRD. METHODS: A double-blind, placebo-controlled, prospective study comparing 8 weeks of treatment with Alginos Oral Suspension (TTY Biopharm Co. Ltd., Taipei, Taiwan) (sodium alginate 1,000 mg three times daily) with a placebo was conducted on patients who fulfilled the criteria of at least one symptom consistent with LPRD, a total reflux symptom index (RSI) score of > 10, and a total reflux finding score (RFS) of > 5...
February 5, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29399798/in-response-to-should-infants-who-fail-their-newborn-hearing-screen-undergo-cytomegalovirus-testing
#19
LETTER
Albert H Park
No abstract text is available yet for this article.
February 5, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29399797/the-survival-impact-of-surgical-therapy-in-squamous-cell-carcinoma-of-the-hard-palate
#20
Jose E Alonso, Albert Y Han, Edward C Kuan, Madeline Strohl, Jon Mallen-St Clair, Maie A St John, William R Ryan, Chase M Heaton
OBJECTIVE: To describe the incidence and determinants of survival of patients with squamous cell carcinoma of the hard palate (SCCHP) between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database. METHODS: Retrospective, population-based cohort study of patients in the SEER tumor registry who were diagnosed with SCCHP from 1973 to 2014. Outcomes and measures included overall survival (OS) and disease-specific survival (DSS)...
February 5, 2018: Laryngoscope
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