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Laryngoscope

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https://www.readbyqxmd.com/read/29044631/frailty-hospital-volume-and-failure-to-rescue-after-head-and-neck-cancer-surgery
#1
Carrie L Nieman, C Matthew Stewart, David W Eisele, Peter J Pronovost, Christine G Gourin
OBJECTIVES/HYPOTHESIS: We previously reported that high-volume hospital head and neck cancer (HNCA) surgical care is associated with decreased mortality, largely explained by reduced rates of failure to rescue. Frailty is an independent predictor of mortality, but is significantly less likely in patients receiving high-volume care. We investigate whether differences in frailty rates explain the relationship between volume and outcomes in HNCA patients and whether frailty confounds the relationship between failure to rescue and mortality...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29044543/investigating-the-effects-of-laryngotracheal-stenosis-on-upper-airway-aerodynamics
#2
Tracy Cheng, David Carpenter, Seth Cohen, David Witsell, Dennis O Frank-Ito
OBJECTIVE: Very little is known about the impact of laryngotracheal stenosis (LTS) on inspiratory airflow and resistance, especially in air hunger states. This study investigates the effect of LTS on airway resistance and volumetric flow across three different inspiratory pressures. METHODS: Head-and-neck computed tomography scans of 11 subjects from 2010 to 2016 were collected. Three-dimensional reconstructions of the upper airway from the nostrils to carina, including the oral cavity, were created for one subject with a normal airway and for 10 patients with LTS...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29044537/in-vivo-imaging-of-the-internal-nasal-valve-during-different-conditions-using-optical-coherence-tomography
#3
Anna S Englhard, Maximilian Wiedmann, Georg J Ledderose, Bryan Lemieux, Alan Badran, Joseph C Jing, Zhongping Chen, Veronika Volgger, Brian J F Wong
OBJECTIVE: Previously, we proposed long-range optical coherence tomography (LR-OCT) to be an effective method for the quantitative evaluation of the nasal valve geometry. Here, the objective was to quantify the reduction in the internal nasal valve angle and cross-sectional area that results in subjective nasal airway obstruction and to evaluate the dynamic behavior of the valve during respiration using LR-OCT. METHODS: For 16 healthy individuals, LR-OCT was performed in each naris during: 1) normal respiration, 2) peak forced inspiration, 3) lateral nasal wall depression (to the onset of obstructive symptoms), and 4) after application of a topical decongestant...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29044536/effect-of-matrix-metalloproteinase-inhibitor-on-disrupted-e-cadherin-after-acid-exposure-in-the-human-nasal-epithelium
#4
Byoungjae Kim, Hyun-Ji Lee, Nu-Ri Im, Doh Young Lee, Cha Young Kang, Il-Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung-Kuk Baek, Tae Hoon Kim
OBJECTIVE: Laryngopharyngeal reflux disease (LPRD) is one of potential factors in recalcitrant chronic rhinosinusitis with or without polyps. An increase in junctional permeability in the nasal mucosa in LPRD may be due to disrupted protein bridge formation with cell-to-cell adhesion molecules such as E-cadherin. Despite the relationship between nasal mucosal inflammation and LPRD, the clear mechanism by which acid reflux affects the nasal epithelium remains unclear. METHODS: The expression levels and distribution patterns of E-cadherin in primary culture of nasal epithelial cells after acid exposure with or without dexamethasone and matrix metalloproteinase (MMP) inhibitor were determined using Western blot and immunocytochemistry...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28994126/staphylococcus-aureus-v8-protease-disrupts-the-integrity-of-the-airway-epithelial-barrier-and-impairs-il-6-production-in-vitro
#5
Jae Murphy, Mahnaz Ramezanpour, Natalia Stach, Grzegorz Dubin, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
OBJECTIVE: Staphylococcus aureus (S. aureus) infection is known to contribute to the severity and recalcitrance of chronic rhinosinusitis (CRS), and its secreted products have been shown to alter the airway barrier. Extracellular proteases secreted by S. aureus are thought to be important in epithelial infection and immune evasion; however, their effect on airway mucosal barrier function is not known. METHODS: To investigate the impact of extracellular proteases on airway epithelial integrity, the purified S...
October 10, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28994125/propionibacterium-acnes-as-an-emerging-pathogen-in-skull-base-osteomyelitis-a-case-series
#6
Heather K Schopper, Jonathan L Hatch, Ted A Meyer
Skull base osteomyelitis (SBO) is recognized as a potentially life-threatening infection that has been classically attributed to Pseudomonas aeruginosa. However, growing data shows that the bacteriology of SBO is changing. Traditionally thought of as commensal bacterium, P. acnes has been implicated as a serious pathogen in other specialties. Building on a previous case report from our institution, we have identified three patients with SBO who are culture-positive for Propionibacterium acnes as a single isolate...
October 10, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28994120/complications-after-endoscopic-laryngopharyngeal-surgery
#7
Yo Kishimoto, Tohru Sogami, Ryuji Uozumi, Makiko Funakoshi, Shin-Ichi Miyamoto, Morimasa Kitamura, Chiaki Suzuki, Manabu Muto, Ichiro Tateya, Koichi Omori
OBJECTIVES/HYPOTHESIS: Endoscopic laryngopharyngeal surgery (ELPS), a hybrid of head and neck surgery and gastrointestinal endoscopic treatment, has been attracting attention as a new therapeutic modality for superficial laryngopharyngeal cancers. Although this technique is less invasive than traditional open procedures, some complications including postoperative bleeding, subcutaneous emphysema, or aspiration pneumonia can occur after treatment. The purpose of this study was to investigate the complications associated with ELPS to better understand the indications for this procedure...
October 10, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990700/application-of-the-eighth-edition-american-joint-committee-on-cancer-staging-system-for-hpv-related-oropharyngeal-cancer-treated-with-transoral-robotic-surgery
#8
Arvind K Badhey, Ashley Olson, Sameep Kadakia, Jack Russo, Peter Ting, Mian Khalid, Mike Yao, Marita S Teng, Eric M Genden, Brett A Miles, Raymond L Chai
OBJECTIVE: Analyze patients treated with transoral robotic surgery (TORS) in the context of the eighth edition of the American Joint Committee on Cancer (AJCC) staging system. METHODS: Retrospective cohort study including 110 human papillomavirus-related oropharyngeal cancer (HPV+OPC) patients with a minimum 1-year follow-up treated with TORS between 2007 to 2016. Kaplan-Meier methods were used to estimate 3-year disease-free survival and assess differences in recurrence...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990693/impact-of-medialization-laryngoplasty-on-dynamic-nanomechanical-vocal-fold-structure-properties
#9
Gregory R Dion, Peter A Benedict, Paulo G Coelho, Milan R Amin, Ryan C Branski
OBJECTIVES/HYPOTHESIS: Although the primary goal of medialization laryngoplasty is to improve glottic closure, implant placement is also likely to alter the biomechanical properties of the vocal fold (VF). We sought to employ novel, nanoscale technology to quantify these properties following medialization based on the hypothesis that different medialization materials will likely yield differential biomechanical effects. STUDY DESIGN: Ex vivo. METHODS: Nine pig larynges were divided into three groups: control, Silastic (Dow Corning, Midland, Michigan, U...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990685/national-trends-in-otolaryngology-intern-curricula-following-accreditation-council-for-graduate-medical-education-changes
#10
Kevin J Kovatch, Rebecca S Harvey, Mark E P Prince, Marc C Thorne
OBJECTIVES/HYPOTHESIS: In 2016, Accreditation Council for Graduate Medical Education (ACGME) requirements for curriculum and resident experiences were modified to require entering postgraduate year (PGY)-1 residents to spend 6 months of structured education on otolaryngology-head and neck surgery (ORL-HNS) rotations. We aimed to determine how ORL-HNS training programs have adapted curricula in response to 2016 ACGME curriculum requirement changes. STUDY DESIGN: Survey study...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990675/the-saline-challenge-a-test-of-injection-laryngoplasty-outcome
#11
Rachel Kaye, Catherine Sinclair, Andrew Blitzer
No abstract text is available yet for this article.
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990674/the-futility-of-intraoperative-frozen-section-in-the-evaluation-of-follicular-thyroid-lesions
#12
Craig A Bollig, David Lesko, David Gilley, Laura M Dooley
OBJECTIVE: Investigate the utility of intraoperative frozen section (iFS) in patients with follicular thyroid lesions following publication of the 2015 American Thyroid Association (ATA) guidelines. STUDY DESIGN: Retrospective chart review. METHODS: Patient demographics, preoperative cytology, frozen pathology, and final pathology were reviewed on patients undergoing thyroid surgery at a tertiary care hospital in which iFS was utilized over a 5-year period...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990673/clinical-characteristics-and-outcomes-of-major-salivary-gland-malignancies-in-children
#13
Shannon Radomski, Sarah Dermody, Earl H Harley
OBJECTIVES/HYPOTHESIS: Determine demographics, clinical characteristics, and survival rates for children with primary salivary gland malignancies. STUDY DESIGN: Retrospective, population-based cohort study. METHODS: All cases of primary salivary gland malignancies diagnosed between the years of 2002 and 2013 in patients ages 0 to 19 years were extracted from the National Cancer Institute's Surveillance, Epidemiology, and End Results database...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990667/the-%C3%A3-ndice-flesch-szigriszt-and-spanish-lexile-analyzer-to-evaluate-spanish-patient-education-materials-in-otolaryngology
#14
Samih J Nassif, Kevin Wong, Jessica R Levi
OBJECTIVES/HYPOTHESIS: Evaluate the reading difficulty of Spanish patient education materials using the validated Índice Flesch-Szigriszt (INFLESZ) and Spanish Lexile Analyzer, and to identify relationships between English and Spanish readability formulas. STUDY DESIGN: Cross-sectional analysis. METHODS: All otolaryngology-related patient education articles written in Spanish from the health libraries of the top 10 US News & World Report-ranked hospitals, top 10 Doximity-ranked otolaryngology residencies, the American Academy of Otolaryngology-Head and Neck Surgery website, and the US National Library of Medicine online section on ears, nose and throat were collected...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990664/hormone-receptors-analysis-in-idiopathic-progressive-subglottic-stenosis
#15
Ivana Fiz, Zeid Bittar, Cesare Piazza, Jan Constantin Koelmel, Federico Gatto, Diego Ferone, Francesco Fiz, Diana Di Dio, Alexander Bosse, Giorgio Peretti, Christian Sittel
OBJECTIVE: Idiopathic subglottic stenosis predominantly affects fertile and perimenopausal women. Estrogens and/or progesterone have been proposed as mediators of its pathogenesis by stimulating collagen deposition within the upper airway. We evaluated the presence and expression of estrogen-alpha (ER-α), estrogen-beta (ER-β), and progesterone receptors (PR) in idiopathic stenotic patients. STUDY DESIGN: A retrospective analysis on 42 surgical specimens from idiopathic stenosis female patients (mean age, 52...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990663/adaptation-and-validation-of-the-spanish-version-of-the-tonsil-and-adenoid-health-status-instrument
#16
Laura Samara, Eduard Esteller, Maria J Dura, Miquel Guirao, Alda Cardesin, Michael Stewart, Francisco Larrosa
OBJECTIVES/HYPOTHESIS: The Tonsil and Adenoid Health Status Instrument (TAHSI) is a disease-specific questionnaire, intended for completion by parents, for assessing quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the TAHSI, thus allowing comparison across studies and international multicenter projects. STUDY DESIGN: Multicenter prospective instrument validation study...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990662/the-radioanatomy-of-endonasal-flap-coverage-of-skull-base-defects-a-tool-for-preoperative-planning
#17
Francisco J D MacArthur, Gerald W McGarry
OBJECTIVES/HYPOTHESIS: To develop a tool for the calculation of surgical skull base defects and endonasal flap dimensions on preoperative computed tomography (CT) to aid surgical planning. STUDY DESIGN: Case series. METHODS: A literature search was conducted to identify all endonasal flaps. There were five basic models identified. These are the nasoseptal flap, anterior lateral nasal wall flap, bipedicled anterior septal flap, posterior pedicled inferior turbinate flap, and middle turbinate flap...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990661/second-tympanostomy-tube-placement-in-children-with-recurrent-acute-otitis-media
#18
Phillip Huyett, Joshua J Sturm, Amber D Shaffer, Dennis J Kitsko, David H Chi
OBJECTIVES/HYPOTHESIS: To determine the rate and predictors of electing for a second bilateral myringotomy and tympanostomy tube placement (BMT) in children with recurrent acute otitis media (RAOM). STUDY DESIGN: Retrospective chart review. METHODS: Charts of 600 children who underwent BMT for RAOM between 2012 and 2014 were reviewed. RESULTS: The overall rate of a second BMT was 15.2% (91/600) and occurred a median of 1...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990660/relationship-of-stroke-risk-and-hearing-loss-in-african-americans-the-jackson-heart-study
#19
Jonathan E Sorrel, Charles E Bishop, Christopher Spankovich, Dan Su, Karen Valle, Samantha Seals, John M Schweinfurth
OBJECTIVES/HYPOTHESIS: To evaluate the relationships among measures of stroke risk and hearing in an African American cardiovascular study cohort. STUDY DESIGN: Prospective cohort study. METHODS: The relationships between stroke risk profiles and hearing of 1,107 individuals from a cohort of African Americans were assessed. Several different hearing pure-tone averages (PTAs) were constructed representing different frequency regions of hearing, namely PTA low, PTA mid, and PTA high...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28990655/round-window-plugging-in-the-treatment-of-superior-semicircular-canal-dehiscence
#20
Eric F Succar, Periakaruppan V Manickam, Sara Wing, Jeffrey Walter, Joseph S Greene, William J Azeredo
OBJECTIVES/HYPOTHESIS: Objectives were to describe the use of round window plugging for superior semicircular canal dehiscence syndrome and review further recommendations regarding the procedure based on our experience and to compare results with recent literature on round window plugging. STUDY DESIGN: Retrospective case series. METHODS: Fourteen patients underwent round window plugging for superior semicircular canal dehiscence at our institution from 2012 to 2015...
October 9, 2017: Laryngoscope
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