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Lancet Oncology

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https://www.readbyqxmd.com/read/30639094/more-evidence-for-implant-based-breast-reconstruction
#1
Nicola Rocco, Giuseppe Catanuto
No abstract text is available yet for this article.
January 9, 2019: Lancet Oncology
https://www.readbyqxmd.com/read/30639093/short-term-safety-outcomes-of-mastectomy-and-immediate-implant-based-breast-reconstruction-with-and-without-mesh-ibra-a-multicentre-prospective-cohort-study
#2
Shelley Potter, Elizabeth J Conroy, Ramsey I Cutress, Paula R Williamson, Lisa Whisker, Steven Thrush, Joanna Skillman, Nicola L P Barnes, Senthurun Mylvaganam, Elisabeth Teasdale, Abhilash Jain, Matthew D Gardiner, Jane M Blazeby, Chris Holcombe
BACKGROUND: Use of biological or synthetic mesh might improve outcomes of immediate implant-based breast reconstruction-breast reconstruction with implants or expanders at the time of mastectomy-but there is a lack of high-quality evidence to support the safety or effectiveness of the technique. We aimed to establish the short-term safety of immediate implant-based breast reconstruction performed with and without mesh, to inform the feasibility of undertaking a future randomised clinical trial comparing different breast reconstruction techniques...
January 9, 2019: Lancet Oncology
https://www.readbyqxmd.com/read/30630773/cns-border-posts-against-rituximab
#3
Benjamin Kasenda, Gerald Illerhaus
No abstract text is available yet for this article.
January 7, 2019: Lancet Oncology
https://www.readbyqxmd.com/read/30630772/rituximab-in-patients-with-primary-cns-lymphoma-hovon-105-allg-nhl-24-a-randomised-open-label-phase-3-intergroup-study
#4
Jacoline E C Bromberg, Samar Issa, Katerina Bakunina, Monique C Minnema, Tatjana Seute, Marc Durian, Gavin Cull, Harry C Schouten, Wendy B C Stevens, Josee M Zijlstra, Joke W Baars, Marcel Nijland, Kylie D Mason, Aart Beeker, Martin J van den Bent, Max Beijert, Michael Gonzales, Daphne de Jong, Jeanette K Doorduijn
BACKGROUND: The prognosis for primary CNS lymphoma has improved with the use of high-dose methotrexate-based chemotherapy, but patient outcomes remain poor. Rituximab, a chimeric monoclonal antibody that targets the CD20 cell surface protein, has substantial activity in systemic CD20-positive diffuse large B-cell lymphoma, but its efficacy in primary CNS lymphoma is unknown and low penetration of the large rituximab molecule through the blood-brain barrier could limit its effect. We aimed to investigate the addition of rituximab to a high-dose methotrexate-based chemotherapy regimen in patients with newly diagnosed primary CNS lymphoma...
January 7, 2019: Lancet Oncology
https://www.readbyqxmd.com/read/30583848/diagnosis-of-thyroid-cancer-using-deep-convolutional-neural-network-models-applied-to-sonographic-images-a-retrospective-multicohort-diagnostic-study
#5
Xiangchun Li, Sheng Zhang, Qiang Zhang, Xi Wei, Yi Pan, Jing Zhao, Xiaojie Xin, Chunxin Qin, Xiaoqing Wang, Jianxin Li, Fan Yang, Yanhui Zhao, Meng Yang, Qinghua Wang, Zhiming Zheng, Xiangqian Zheng, Xiangming Yang, Christopher T Whitlow, Metin Nafi Gurcan, Lun Zhang, Xudong Wang, Boris C Pasche, Ming Gao, Wei Zhang, Kexin Chen
BACKGROUND: The incidence of thyroid cancer is rising steadily because of overdiagnosis and overtreatment conferred by widespread use of sensitive imaging techniques for screening. This overall incidence growth is especially driven by increased diagnosis of indolent and well-differentiated papillary subtype and early-stage thyroid cancer, whereas the incidence of advanced-stage thyroid cancer has increased marginally. Thyroid ultrasound is frequently used to diagnose thyroid cancer. The aim of this study was to use deep convolutional neural network (DCNN) models to improve the diagnostic accuracy of thyroid cancer by analysing sonographic imaging data from clinical ultrasounds...
December 21, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30583847/on-algorithms-machines-and-medicine
#6
Enrico Coiera
No abstract text is available yet for this article.
December 21, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30579763/short-term-androgen-suppression-and-radiotherapy-versus-intermediate-term-androgen-suppression-and-radiotherapy-with-or-without-zoledronic-acid-in-men-with-locally-advanced-prostate-cancer-trog-03-04-radar-10-year-results-from-a-randomised-phase-3-factorial
#7
James W Denham, David Joseph, David S Lamb, Nigel A Spry, Gillian Duchesne, John Matthews, Chris Atkinson, Keen-Hun Tai, David Christie, Lizbeth Kenny, Sandra Turner, Nirdosh Kumar Gogna, Terry Diamond, Brett Delahunt, Chris Oldmeadow, John Attia, Allison Steigler
BACKGROUND: The optimal duration of androgen suppression for men with locally advanced prostate cancer receiving radiotherapy with curative intent is yet to be defined. Zoledronic acid is effective in preventing androgen suppression-induced bone loss, but its role in preventing castration-sensitive bone metastases in locally advanced prostate cancer is unclear. The RADAR trial assessed whether the addition of 12 months of adjuvant androgen suppression, 18 months of zoledronic acid, or both, can improve outcomes in men with locally advanced prostate cancer who receive 6 months of androgen suppression and prostatic radiotherapy...
December 19, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30579762/androgen-deprivation-therapy-in-prostate-cancer-new-findings-and-questions-for-the-future
#8
Oliver Sartor
No abstract text is available yet for this article.
December 19, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30578024/anti-angiogenic-therapy-for-malignant-solitary-fibrous-tumour-validation-through-collaboration
#9
Richard F Riedel
No abstract text is available yet for this article.
December 18, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30578023/pazopanib-for-treatment-of-advanced-malignant-and-dedifferentiated-solitary-fibrous-tumour-a-multicentre-single-arm-phase-2-trial
#10
Javier Martin-Broto, Silvia Stacchiotti, Antonio Lopez-Pousa, Andres Redondo, Daniel Bernabeu, Enrique de Alava, Paolo G Casali, Antoine Italiano, Antonio Gutierrez, David S Moura, Maria Peña-Chilet, Juan Diaz-Martin, Michele Biscuola, Miguel Taron, Paola Collini, Dominique Ranchere-Vince, Xavier Garcia Del Muro, Giovanni Grignani, Sarah Dumont, Javier Martinez-Trufero, Emanuela Palmerini, Nadia Hindi, Ana Sebio, Joaquin Dopazo, Angelo Paolo Dei Tos, Axel LeCesne, Jean-Yves Blay, Josefina Cruz
BACKGROUND: A solitary fibrous tumour is a rare soft-tissue tumour with three clinicopathological variants: typical, malignant, and dedifferentiated. Preclinical experiments and retrospective studies have shown different sensitivities of solitary fibrous tumour to chemotherapy and antiangiogenics. We therefore designed a trial to assess the activity of pazopanib in a cohort of patients with malignant or dedifferentiated solitary fibrous tumour. The clinical and translational results are presented here...
December 18, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30573286/new-directions-in-penile-cancer
#11
Peter A S Johnstone, Philippe E Spiess, Anna R Giuliano
No abstract text is available yet for this article.
December 17, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30573285/prevalence-of-human-papillomavirus-dna-and-p16-ink4a-in-penile-cancer-and-penile-intraepithelial-neoplasia-a-systematic-review-and-meta-analysis
#12
Tina Bech Olesen, Freja Lærke Sand, Christina Louise Rasmussen, Vanna Albieri, Birgitte Grønkær Toft, Bodil Norrild, Christian Munk, Susanne Krüger Kjær
BACKGROUND: Although previous meta-analyses have examined human papillomavirus (HPV) DNA prevalence in penile cancer, none, to our knowledge, have assessed pooled HPV DNA prevalence in penile intraepithelial neoplasia or p16INK4a percent positivity in penile cancer and penile intraepithelial neoplasia. Therefore, we aimed to examine the prevalence of HPV DNA and p16INK4a positivity in penile cancer and penile intraepithelial neoplasia worldwide. METHODS: In this systematic review and meta-analysis, we searched PubMed, Embase, and the Cochrane Library until July 24, 2017, for English-language articles published from Jan 1, 1986, onwards reporting the prevalence of HPV DNA and p16INK4a positivity, either alone or in combination, in at least five cases of penile cancer or penile intraepithelial neoplasia...
December 17, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30559052/lenalidomide-as-maintenance-for-every-newly-diagnosed-patient-with-multiple-myeloma
#13
María-Victoria Mateos, Verónica González de la Calle
No abstract text is available yet for this article.
December 14, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30559051/lenalidomide-maintenance-versus-observation-for-patients-with-newly-diagnosed-multiple-myeloma-myeloma-xi-a-multicentre-open-label-randomised-phase-3-trial
#14
Graham H Jackson, Faith E Davies, Charlotte Pawlyn, David A Cairns, Alina Striha, Corinne Collett, Anna Hockaday, John R Jones, Bhuvan Kishore, Mamta Garg, Cathy D Williams, Kamaraj Karunanithi, Jindriska Lindsay, Matthew W Jenner, Gordon Cook, Nigel H Russell, Martin F Kaiser, Mark T Drayson, Roger G Owen, Walter M Gregory, Gareth J Morgan
BACKGROUND: Patients with multiple myeloma treated with lenalidomide maintenance therapy have improved progression-free survival, primarily following autologous stem-cell transplantation. A beneficial effect of lenalidomide maintenance therapy on overall survival in this setting has been inconsistent between individual studies. Minimal data are available on the effect of maintenance lenalidomide in more aggressive disease states, such as patients with cytogenetic high-risk disease or patients ineligible for transplantation...
December 14, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30555022/t-dm1-for-residual-invasive-her2-positive-breast-cancer
#15
Talha Khan Burki
No abstract text is available yet for this article.
December 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30555021/probiotics-for-chemoradiotherapy-induced-oral-mucositis
#16
Manjulika Das
No abstract text is available yet for this article.
December 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30545752/surgical-treatment-and-survival-from-colorectal-cancer-in-denmark-england-norway-and-sweden-a-population-based-study
#17
Sara Benitez Majano, Chiara Di Girolamo, Bernard Rachet, Camille Maringe, Marianne Grønlie Guren, Bengt Glimelius, Lene Hjerrild Iversen, Edrun Andrea Schnell, Kristina Lundqvist, Jane Christensen, Melanie Morris, Michel P Coleman, Sarah Walters
BACKGROUND: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival. METHODS: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries...
December 10, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30545751/the-importance-of-surgery-in-colorectal-cancer-treatment
#18
Eva Angenete
No abstract text is available yet for this article.
December 10, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30528628/2018-american-society-of-hematology-annual-meeting
#19
Katherine Gourd
No abstract text is available yet for this article.
December 6, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/30522968/drug-development-for-glioma-are-we-repeating-the-same-mistakes
#20
Roger Stupp
No abstract text is available yet for this article.
December 3, 2018: Lancet Oncology
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