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Lancet Neurology

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https://www.readbyqxmd.com/read/28800868/nor-test-ing-tenecteplase-in-acute-ischaemic-stroke
#1
Craig S Anderson
No abstract text is available yet for this article.
August 8, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28780236/tenecteplase-versus-alteplase-for-management-of-acute-ischaemic-stroke-nor-test-a-phase-3-randomised-open-label-blinded-endpoint-trial
#2
Nicola Logallo, Vojtech Novotny, Jörg Assmus, Christopher E Kvistad, Lars Alteheld, Ole Morten Rønning, Bente Thommessen, Karl-Friedrich Amthor, Hege Ihle-Hansen, Martin Kurz, Håkon Tobro, Kamaljit Kaur, Magdalena Stankiewicz, Maria Carlsson, Åse Morsund, Titto Idicula, Anne Hege Aamodt, Christian Lund, Halvor Næss, Ulrike Waje-Andreassen, Lars Thomassen
BACKGROUND: Tenecteplase is a newer thrombolytic agent with some pharmacological advantages over alteplase. Previous phase 2 trials of tenecteplase in acute ischaemic stroke have shown promising results. We aimed to investigate the safety and efficacy of tenecteplase versus alteplase in patients with acute stroke who were eligible for intravenous thrombolysis. METHODS: This phase 3, randomised, open-label, blinded endpoint, superiority trial was done in 13 stroke units in Norway...
August 2, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28716372/corrections
#3
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28716371/detection-risk-factors-and-functional-consequences-of-cerebral-microinfarcts
#4
REVIEW
Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels
Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the small size of these lesions, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measurable disruption to structural brain connections, and are associated with dementia that is independent of Alzheimer's disease pathology or larger infarcts (ie, lacunar infarcts, and large cortical and non-lacunar subcortical infarcts). Substantial progress has been made with regard to understanding risk factors and functional consequences of cerebral microinfarcts, partly driven by new in-vivo detection methods and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts in human beings...
July 14, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713036/intracerebral-gene-therapy-for-mucopolysaccharidosis-type-iiib-syndrome
#5
Kim Hemsley, Adeline Lau
No abstract text is available yet for this article.
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713035/intracerebral-gene-therapy-in-children-with-mucopolysaccharidosis-type-iiib-syndrome-an-uncontrolled-phase-1-2-clinical-trial
#6
Marc Tardieu, Michel Zérah, Marie-Lise Gougeon, Jérome Ausseil, Stéphanie de Bournonville, Béatrice Husson, Dimitrios Zafeiriou, Giancarlo Parenti, Philippe Bourget, Béatrice Poirier, Valérie Furlan, Cécile Artaud, Thomas Baugnon, Thomas Roujeau, Ronald G Crystal, Christian Meyer, Kumaran Deiva, Jean-Michel Heard
BACKGROUND: Mucopolysaccharidosis type IIIB syndrome (also known as Sanfilippo type B syndrome) is a lysosomal storage disease resulting in progressive deterioration of cognitive acquisition after age 2-4 years. No treatment is available for the neurological manifestations of the disease. We sought to assess the safety and efficacy of a novel intracerebral gene therapy. METHODS: Local regulatory authorities in France allowed inclusion of up to four children in this phase 1/2 study...
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713034/marc-tardieu-the-interface-man
#7
Adrian Burton
No abstract text is available yet for this article.
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713033/corrections
#8
(no author information available yet)
No abstract text is available yet for this article.
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28688839/training-non-physicians-as-neurosurgeons-in-sub-saharan-africa
#9
Adrian Burton
No abstract text is available yet for this article.
July 5, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28688838/james-crichton-browne
#10
Ray Cavanaugh
No abstract text is available yet for this article.
July 5, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28684246/imaging-neuroinflammation-to-monitor-%C3%AE-synucleinopathy
#11
Yasuomi Ouchi
No abstract text is available yet for this article.
July 3, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28684245/assessment-of-neuroinflammation-in-patients-with-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-a-case-control-study
#12
Morten Gersel Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Findings from longitudinal follow-up studies in patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) have shown that most patients will eventually develop the synucleinopathies Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Neuroinflammation in the form of microglial activation is present in synucleinopathies and is a potential therapeutic target to halt or delay the neurodegenerative process. We aimed to investigate whether neuroinflammation is present in patients with IRBD and its possible relation to nigrostriatal dopamine function...
July 3, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28673545/eric-reiman-aiming-to-prevent-alzheimer-s-disease
#13
Tony Kirby
No abstract text is available yet for this article.
June 30, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28668373/corrections
#14
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28647156/corrections
#15
(no author information available yet)
No abstract text is available yet for this article.
June 21, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28645854/deep-brain-stimulation-in-tourette-s-syndrome-new-insights
#16
David J Pedrosa, Lars Timmermann
No abstract text is available yet for this article.
June 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28642124/identification-of-genetic-variants-associated-with-huntington-s-disease-progression-a-genome-wide-association-study
#17
Davina J Hensman Moss, Antonio F Pardiñas, Douglas Langbehn, Kitty Lo, Blair R Leavitt, Raymund Roos, Alexandra Durr, Simon Mead, Peter Holmans, Lesley Jones, Sarah J Tabrizi
BACKGROUND: Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. METHODS: We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008-11)...
June 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28642125/safety-and-efficacy-of-dual-lead-thalamic-deep-brain-stimulation-for-patients-with-treatment-refractory-multiple-sclerosis-tremor-a-single-centre-randomised-single-blind-pilot-trial
#18
Seth F Oliveria, Ramon L Rodriguez, Dawn Bowers, Daniel Kantor, Justin D Hilliard, Erin H Monari, Bonnie M Scott, Michael S Okun, Kelly D Foote
BACKGROUND: Efficacy in previous studies of surgical treatments of refractory multiple sclerosis tremor using lesioning or deep brain stimulation (DBS) has been variable. The aim of this study was to investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius-ventralis oralis posterior nucleus border [the VIM lead] and one targeting the ventralis oralis anterior-ventralis oralis posterior border [the VO lead]) for the treatment of multiple sclerosis tremor...
June 19, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28642123/multiple-sclerosis-tremor-are-technical-advances-enough
#19
Derrick Soh, Alfonso Fasano
No abstract text is available yet for this article.
June 19, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28642122/identifying-modifiers-of-huntington-s-disease-progression
#20
Carsten Saft
No abstract text is available yet for this article.
June 19, 2017: Lancet Neurology
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