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Lancet Neurology

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https://www.readbyqxmd.com/read/28065504/greg-albers-changing-the-face-of-the-stroke-stopwatch
#1
Jules Morgan
No abstract text is available yet for this article.
January 5, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27989553/cerebrovascular-function-in-presymptomatic-and-symptomatic-individuals-with-hereditary-cerebral-amyloid-angiopathy-a-case-control-study
#2
Anna M van Opstal, Sanneke van Rooden, Thijs van Harten, Eidrees Ghariq, Gerda Labadie, Panagiotis Fotiadis, M Edip Gurol, Gisela M Terwindt, Marieke J H Wermer, Mark A van Buchem, Steven M Greenberg, Jeroen van der Grond
BACKGROUND: Previous work suggests that impairments of cerebrovascular flow or reactivity might be early markers of cerebral amyloid angiopathy (CAA). Hereditary cerebral haemorrhage with amyloidosis-Dutch type (HCHWA-D) is a genetic form of CAA that can be diagnosed before the onset of clinical symptoms by DNA testing. We aimed to investigate whether haemodynamic measures are decreased in presymptomatic and symptomatic HCHWA-D mutation carriers compared with healthy controls. METHODS: In this case-control study, we included presymptomatic and symptomatic HCHWA-D mutation carriers diagnosed through genetic testing and recruited through the HCHWA-D patient association (Katwijk, Netherlands) and the outpatient clinic of the Department of Neurology of the Leiden University Medical Center (Leiden, Netherlands), and healthy controls...
December 15, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27989552/defining-early-caa-insights-from-a-rare-monogenic-disorder
#3
Eric E Smith
No abstract text is available yet for this article.
December 15, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27955996/anti-tau-vaccine-in-alzheimer-s-disease-a-tentative-step
#4
Francesco Panza, Giancarlo Logroscino
No abstract text is available yet for this article.
December 9, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27955995/safety-and-immunogenicity-of-the-tau-vaccine-aadvac1-in-patients-with-alzheimer-s-disease-a-randomised-double-blind-placebo-controlled-phase-1-trial
#5
Petr Novak, Reinhold Schmidt, Eva Kontsekova, Norbert Zilka, Branislav Kovacech, Rostislav Skrabana, Zuzana Vince-Kazmerova, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Bengt Winblad, Michal Novak
BACKGROUND: Neurofibrillary pathology composed of tau protein is a main correlate of cognitive impairment in patients with Alzheimer's disease. Immunotherapy targeting pathological tau proteins is therefore a promising strategy for disease-modifying treatment of Alzheimer's disease. We have developed an active vaccine, AADvac1, against pathological tau proteins and assessed it in a phase 1 trial. METHODS: We did a first-in-man, phase 1, 12 week, randomised, double-blind, placebo-controlled study of AADvac1 with a 12 week open-label extension in patients aged 50-85 years with mild-to-moderate Alzheimer's disease at four centres in Austria...
December 9, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27964824/pain-in-amyotrophic-lateral-sclerosis
#6
REVIEW
Adriano Chiò, Gabriele Mora, Giuseppe Lauria
Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS) although it is reported by most of these patients. It occurs at all stages of the disease and can be an onset symptom preceding motor dysfunction. Pain is correlated with a deterioration in patients' quality of life and increased prevalence of depression. In the later stages of ALS, pain can be severe enough to require increased use of sedative and analgesic drugs, and is among the events that predict clinical deterioration and death...
December 7, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27865686/david-knopman-connecting-the-images-in-dementia-research
#7
Jules Morgan
No abstract text is available yet for this article.
November 16, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27818158/ammar-al-chalabi-from-complex-genetics-to-acoustic-rock
#8
Jules Morgan
No abstract text is available yet for this article.
November 3, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/28029517/stroke-1-2-0-a-rapid-response-programme-for-stroke-in-china
#9
LETTER
Jing Zhao, Renyu Liu
No abstract text is available yet for this article.
October 28, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27777022/clinical-phenotype-and-genetic-associations-in-autosomal-dominant-familial-alzheimer-s-disease-a-case-series
#10
Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox
BACKGROUND: The causes of phenotypic heterogeneity in familial Alzheimer's disease with autosomal dominant inheritance are not well understood. We aimed to characterise clinical phenotypes and genetic associations with APP and PSEN1 mutations in symptomatic autosomal dominant familial Alzheimer's disease (ADAD). METHODS: We retrospectively analysed genotypic and phenotypic data (age at symptom onset, initial cognitive or behavioural symptoms, and presence of myoclonus, seizures, pyramidal signs, extrapyramidal signs, and cerebellar signs) from all individuals with ADAD due to APP or PSEN1 mutations seen at the Dementia Research Centre in London, UK...
October 21, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27777021/clinical-heterogeneity-in-familial-alzheimer-s-disease
#11
Wiesje M Van der Flier
No abstract text is available yet for this article.
October 21, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27979359/movement-disorders-in-2016-from-genes-to-phenotypes
#12
Paolo Calabresi, Nicola Tambasco
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979358/dna-repair-in-the-trinucleotide-repeat-disorders
#13
Lesley Jones, Henry Houlden, Sarah J Tabrizi
BACKGROUND: Inherited diseases caused by unstable repeated DNA sequences are rare, but together represent a substantial cause of morbidity. Trinucleotide repeat disorders are severe, usually life-shortening, neurological disorders caused by nucleotide expansions, and most have no disease-modifying treatments. Longer repeat expansions are associated with genetic anticipation (ie, earlier disease onset in successive generations), although the differences in age at onset are not entirely accounted for by repeat length...
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979357/epilepsy-research-in-2016-new-treatment-directions
#14
Samuel F Berkovic
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979356/neuropathological-and-genetic-correlates-of-survival-and-dementia-onset-in-synucleinopathies-a-retrospective-analysis
#15
David J Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, John E Duda, Sharon X Xie, Edward B Lee, Vivianna M Van Deerlin, Oscar L Lopez, Julia K Kofler, Peter T Nelson, Gregory A Jicha, Randy Woltjer, Joseph F Quinn, Jeffery Kaye, James B Leverenz, Debby Tsuang, Katelan Longfellow, Dora Yearout, Walter Kukull, C Dirk Keene, Thomas J Montine, Cyrus P Zabetian, John Q Trojanowski
BACKGROUND: Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies. METHODS: In this retrospective study, we examined symptom onset, and genetic and neuropathological data from a cohort of patients with Lewy body disorders with autopsy-confirmed α synucleinopathy (as of Oct 1, 2015) who were previously included in other studies from five academic institutions in five cities in the USA...
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979355/the-most-important-advances-in-headache-research-in-2016
#16
Rigmor Hoejland Jensen
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979354/alzheimer-s-disease-and-other-dementias-update-on-research
#17
Lon Schneider
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979353/modern-diagnosis-of-flaubert-s-death-mask
#18
Philippe Charlier, Saudamini Deo
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979352/tsuneya-ikezu
#19
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27979351/placebos-in-clinical-trials-unravelling-a-complex-phenomenon-authors-reply
#20
LETTER
Fabrizio Benedetti, Elisa Carlino, Alessandro Piedimonte
No abstract text is available yet for this article.
January 2017: Lancet Neurology
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