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Lancet Neurology

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https://www.readbyqxmd.com/read/30219655/circadian-and-circaseptan-rhythms-in-human-epilepsy-a-retrospective-cohort-study
#1
Philippa J Karoly, Daniel M Goldenholz, Dean R Freestone, Robert E Moss, David B Grayden, William H Theodore, Mark J Cook
BACKGROUND: Epilepsy has long been suspected to be governed by cyclic rhythms, with seizure rates rising and falling periodically over weeks, months, or even years. The very long scales of seizure patterns seem to defy natural explanation and have sometimes been attributed to hormonal cycles or environmental factors. This study aimed to quantify the strength and prevalence of seizure cycles at multiple temporal scales across a large cohort of people with epilepsy. METHODS: This retrospective cohort study used the two most comprehensive databases of human seizures (SeizureTracker [USA] and NeuroVista [Melbourne, VIC, Australia]) and analytic techniques from circular statistics to analyse patients with epilepsy for the presence and frequency of multitemporal cycles of seizure activity...
September 12, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30219654/from-moon-to-earth-ultradian-cycles-in-brain-excitability
#2
Andreas Schulze-Bonhage
No abstract text is available yet for this article.
September 12, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30172624/plasma-and-csf-biomarkers-for-the-diagnosis-of-alzheimer-s-disease-in-adults-with-down-syndrome-a-cross-sectional-study
#3
Juan Fortea, María Carmona-Iragui, Bessy Benejam, Susana Fernández, Laura Videla, Isabel Barroeta, Daniel Alcolea, Jordi Pegueroles, Laia Muñoz, Olivia Belbin, Mony J de Leon, Aleksandra Maleska Maceski, Christophe Hirtz, Jordi Clarimón, Sebastián Videla, Constance Delaby, Sylvain Lehmann, Rafael Blesa, Alberto Lleó
BACKGROUND: Diagnosis of Alzheimer's disease in Down syndrome is challenging because of the absence of validated diagnostic biomarkers. We investigated the diagnostic performance of plasma and CSF biomarkers in this population. METHODS: We did a cross-sectional study of adults aged 18 years and older with Down syndrome enrolled in a population-based health plan in Catalonia, Spain. Every person with Down syndrome assessed in the health plan was eligible to enter the Down Alzheimer Barcelona Neuroimaging Initiative, and those with a plasma or CSF sample available were included in this study...
August 29, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30172623/diagnostic-biomarkers-of-alzheimer-s-disease-in-down-syndrome
#4
Michael S Rafii
No abstract text is available yet for this article.
August 29, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30170898/pharyngeal-electrical-stimulation-for-early-decannulation-in-tracheotomised-patients-with-neurogenic-dysphagia-after-stroke-phast-trac-a-prospective-single-blinded-randomised-trial
#5
Rainer Dziewas, Rebecca Stellato, Ingeborg van der Tweel, Ernst Walther, Cornelius J Werner, Tobias Braun, Giuseppe Citerio, Mitja Jandl, Michael Friedrichs, Katja Nötzel, Milan R Vosko, Satish Mistry, Shaheen Hamdy, Susan McGowan, Tobias Warnecke, Paul Zwittag, Philip M Bath
BACKGROUND: Dysphagia after stroke is common, especially in severely affected patients who have had a tracheotomy. In a pilot trial, pharyngeal electrical stimulation (PES) improved swallowing function in this group of patients. We aimed to replicate and extend this single-centre experience. METHODS: We did a prospective, single-blind, randomised controlled trial across nine sites (seven acute care hospitals, two rehabilitation facilities) in Germany, Austria, and Italy...
August 28, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30170897/pharyngeal-stimulation-after-stroke-more-evidence-is-needed
#6
Martin Dennis
No abstract text is available yet for this article.
August 28, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30143361/cortical-neuronal-densities-and-cerebral-white-matter-demyelination-in-multiple-sclerosis-a-retrospective-study
#7
Bruce D Trapp, Megan Vignos, Jessica Dudman, Ansi Chang, Elizabeth Fisher, Susan M Staugaitis, Harsha Battapady, Sverre Mork, Daniel Ontaneda, Stephen E Jones, Robert J Fox, Jacqueline Chen, Kunio Nakamura, Richard A Rudick
BACKGROUND: Demyelination of cerebral white matter is thought to drive neuronal degeneration and permanent neurological disability in individuals with multiple sclerosis. Findings from brain MRI studies, however, support the possibility that demyelination and neuronal degeneration can occur independently. We aimed to establish whether post-mortem brains from patients with multiple sclerosis show pathological evidence of cortical neuronal loss that is independent of cerebral white-matter demyelination...
August 21, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30126645/risk-predictors-to-limit-neuronal-loss-after-intracerebral-haemorrhage
#8
M Edip Gurol
No abstract text is available yet for this article.
August 17, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30120039/absolute-risk-and-predictors-of-the-growth-of-acute-spontaneous-intracerebral-haemorrhage-a-systematic-review-and-meta-analysis-of-individual-patient-data
#9
Rustam Al-Shahi Salman, Joseph Frantzias, Robert J Lee, Patrick D Lyden, Thomas W K Battey, Alison M Ayres, Joshua N Goldstein, Stephan A Mayer, Thorsten Steiner, Xia Wang, Hisatomi Arima, Hitoshi Hasegawa, Makoto Oishi, Daniel A Godoy, Luca Masotti, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Dong-Kyu Jang, Antonio Davalos, José Castillo, Xiaoying Yao, Jan Claassen, Bastian Volbers, Seiji Kazui, Yasushi Okada, Shigeru Fujimoto, Kazunori Toyoda, Qi Li, Jane Khoury, Pilar Delgado, José Álvarez Sabín, Mar Hernández-Guillamon, Luis Prats-Sánchez, Chunyan Cai, Mahesh P Kate, Rebecca McCourt, Chitra Venkatasubramanian, Michael N Diringer, Yukio Ikeda, Hans Worthmann, Wendy C Ziai, Christopher D d'Esterre, Richard I Aviv, Peter Raab, Yasuo Murai, Allyson R Zazulia, Kenneth S Butcher, Seyed Mohammad Seyedsaadat, James C Grotta, Joan Martí-Fàbregas, Joan Montaner, Joseph Broderick, Haruko Yamamoto, Dimitre Staykov, E Sander Connolly, Magdy Selim, Rogelio Leira, Byung Hoo Moon, Andrew M Demchuk, Mario Di Napoli, Yukihiko Fujii, Craig S Anderson, Jonathan Rosand
BACKGROUND: Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography. METHODS: In a systematic review of OVID MEDLINE-with additional hand-searching of relevant studies' bibliographies- from Jan 1, 1970, to Dec 31, 2015, we identified observational cohorts and randomised trials with repeat scanning protocols that included at least ten patients with acute intracerebral haemorrhage...
August 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30093250/harry-t-orr-decoding-spinocerebellar-ataxias
#10
Tony Kirby
No abstract text is available yet for this article.
August 6, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30006138/bruce-ransom-energy-inspiration-and-curiosity
#11
Tony Kirby
No abstract text is available yet for this article.
July 10, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29954677/wilder-graves-penfield
#12
Domenico Chirchiglia, Pasquale Chirchiglia, Rosa Marotta
No abstract text is available yet for this article.
June 25, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129477/classification-and-management-of-adult-inflammatory-myopathies
#13
REVIEW
Albert Selva-O'Callaghan, Iago Pinal-Fernandez, Ernesto Trallero-Araguás, José César Milisenda, Josep Maria Grau-Junyent, Andrew L Mammen
Inflammatory myopathies, collectively known as myositis, are heterogeneous disorders characterised by muscle inflammation, and frequently accompanied by extramuscular manifestations that affect the skin, lung, and joints. Patients with inflammatory myopathies were previously classified as having dermatomyositis if characteristic rashes accompanied the muscle involvement, and as having polymyositis if no rashes were present. Five main types of inflammatory myopathies are now widely recognised: dermatomyositis, immune-mediated necrotising myopathy, sporadic inclusion-body myositis, overlap myositis (including antisynthetase syndrome), and polymyositis...
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129476/selective-autophagy-as-a-potential-therapeutic-target-for-neurodegenerative-disorders
#14
REVIEW
Aurora Scrivo, Mathieu Bourdenx, Olatz Pampliega, Ana Maria Cuervo
Cells rely on surveillance systems such as autophagy to handle protein alterations and organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular mechanism for degradation of intracellular components in lysosomes, frequently leads to neurodegeneration. The neuroprotective effect of autophagy stems from its ability to eliminate pathogenic forms of proteins such as α-synuclein or tau. However, the same pathogenic proteins often affect different types and steps of the autophagic process. Furthermore, genetic studies have shown that some proteins related to neurodegeneration, such as huntingtin, participate in autophagy as one of their physiological functions...
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129475/epidemiology-aetiology-and-management-of-ischaemic-stroke-in-young-adults
#15
REVIEW
Merel S Ekker, Esther M Boot, Aneesh B Singhal, Kay Sin Tan, Stephanie Debette, Anil M Tuladhar, Frank-Erik de Leeuw
Epidemiological evidence suggests that the incidence of ischaemic stroke in young adults (18-50 years) has increased substantially. These patients have a long life expectancy after stroke, and the costs of long-term care pose huge challenges to health-care systems. Although the current recommendations for treatment of young and old (>50 years) patients with stroke are similar, the optimal management of young adult patients with stroke is unknown. They are usually not included in trials, and specific subanalyses limited to young adult patients with stroke are usually not done, owing to lower incidence of stroke and lower prevalence of vascular risk factors in young adults...
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129474/traditional-chinese-medicine-for-ischaemic-stroke
#16
Tianlong Liu, Yi Ding, Aidong Wen
No abstract text is available yet for this article.
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129473/rahul-s-desikan
#17
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129472/claw-hand-in-a-renaissance-portrait
#18
LETTER
Alla A Vein, Alexander Mouret
No abstract text is available yet for this article.
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129471/eurap-registry-inadequate-monitoring-of-prescribed-drugs-in-pregnancy
#19
LETTER
Alain Braillon, Susan Bewley
No abstract text is available yet for this article.
September 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30129470/eurap-registry-inadequate-monitoring-of-prescribed-drugs-in-pregnancy-authors-reply
#20
LETTER
Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Anne Sabers, Sanjeev V Thomas, Frank Vajda
No abstract text is available yet for this article.
September 2018: Lancet Neurology
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