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Lancet Neurology

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https://www.readbyqxmd.com/read/27889313/lacosamide-monotherapy-for-newly-diagnosed-epilepsy
#1
Francesco Brigo
No abstract text is available yet for this article.
November 23, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27889312/efficacy-safety-and-tolerability-of-lacosamide-monotherapy-versus-controlled-release-carbamazepine-in-patients-with-newly-diagnosed-epilepsy-a-phase-3-randomised-double-blind-non-inferiority-trial
#2
Michel Baulac, Felix Rosenow, Manuel Toledo, Kiyohito Terada, Ting Li, Marc De Backer, Konrad J Werhahn, Melissa Brock
BACKGROUND: Further options for monotherapy are needed to treat newly diagnosed epilepsy in adults. We assessed the efficacy, safety, and tolerability of lacosamide as a first-line monotherapy option for these patients. METHODS: In this phase 3, randomised, double-blind, non-inferiority trial, patients from 185 epilepsy or general neurology centres in Europe, North America, and the Asia Pacific region, aged 16 years or older and with newly diagnosed epilepsy were randomly assigned in a 1:1 ratio, via a computer-generated code, to receive lacosamide monotherapy or controlled-release carbamazepine (carbamazepine-CR) twice daily...
November 23, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27866858/clinical-variables-and-biomarkers-in-prediction-of-cognitive-impairment-in-patients-with-newly-diagnosed-parkinson-s-disease-a-cohort-study
#3
Anette Schrag, Uzma Faisal Siddiqui, Zacharias Anastasiou, Daniel Weintraub, Jonathan M Schott
BACKGROUND: Parkinson's disease is associated with an increased incidence of cognitive impairment and dementia. Predicting who is at risk of cognitive decline early in the disease course has implications for clinical prognosis and for stratification of participants in clinical trials. We assessed the use of clinical information and biomarkers as predictive factors for cognitive decline in patients with newly diagnosed Parkinson's disease. METHODS: The Parkinson's Progression Markers Initiative (PPMI) study is a cohort study in patients with newly diagnosed Parkinson's disease...
November 17, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27866857/cognitive-impairment-in-parkinson-s-disease
#4
Nour Majbour, Omar El-Agnaf
No abstract text is available yet for this article.
November 17, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27865686/david-knopman-connecting-the-images-in-dementia-research
#5
Jules Morgan
No abstract text is available yet for this article.
November 16, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27864006/corrections
#6
(no author information available yet)
No abstract text is available yet for this article.
November 15, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27838191/combination-therapy-for-treatment-of-infantile-spasms
#7
Raili Riikonen
No abstract text is available yet for this article.
November 9, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27838190/safety-and-effectiveness-of-hormonal-treatment-versus-hormonal-treatment-with-vigabatrin-for-infantile-spasms-iciss-a-randomised-multicentre-open-label-trial
#8
Finbar J K O'Callaghan, Stuart W Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P Osborne
BACKGROUND: Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess whether combining the treatments would be more effective than hormonal therapy alone. METHODS: In this multicentre, open-label randomised trial, 102 hospitals (Australia [three], Germany [11], New Zealand [two], Switzerland [three], and the UK [83]) enrolled infants who had a clinical diagnosis of infantile spasms and a hypsarrhythmic (or similar) EEG no more than 7 days before enrolment...
November 9, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27836433/sex-differences-in-the-epidemiology-clinical-features-and-pathophysiology-of-migraine
#9
REVIEW
Kjersti Grøtta Vetvik, E Anne MacGregor
Migraine is two to three times more prevalent in women than men, and women report a longer attack duration, increased risk of headache recurrence, greater disability, and a longer period of time required to recover. Conditions recognised to be comorbid with migraine include asthma, anxiety, depression, and other chronic pain conditions, and these comorbidities add to the amount of disability in both sexes. Migraine-specifically migraine with aura-has been identified as a risk factor for vascular disorders, particularly in women, but because of the scarcity of data, the comparative risk in men has yet to be established...
November 8, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27818158/ammar-al-chalabi-from-complex-genetics-to-acoustic-rock
#10
Jules Morgan
No abstract text is available yet for this article.
November 3, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27777022/clinical-phenotype-and-genetic-associations-in-autosomal-dominant-familial-alzheimer-s-disease-a-case-series
#11
Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox
BACKGROUND: The causes of phenotypic heterogeneity in familial Alzheimer's disease with autosomal dominant inheritance are not well understood. We aimed to characterise clinical phenotypes and genetic associations with APP and PSEN1 mutations in symptomatic autosomal dominant familial Alzheimer's disease (ADAD). METHODS: We retrospectively analysed genotypic and phenotypic data (age at symptom onset, initial cognitive or behavioural symptoms, and presence of myoclonus, seizures, pyramidal signs, extrapyramidal signs, and cerebellar signs) from all individuals with ADAD due to APP or PSEN1 mutations seen at the Dementia Research Centre in London, UK...
October 21, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27777021/clinical-heterogeneity-in-familial-alzheimer-s-disease
#12
Wiesje M Van der Flier
No abstract text is available yet for this article.
October 21, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27743946/corrections
#13
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27692495/understanding-brain-development-a-major-step
#14
Alan C Evans, Sherif Karama, Lana Wassung, Yasser Iturria-Medina
No abstract text is available yet for this article.
September 27, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839653/micrornas-in-epilepsy-pathophysiology-and-clinical-utility
#15
David C Henshall, Hajo M Hamer, R Jeroen Pasterkamp, David B Goldstein, Jørgen Kjems, Jochen H M Prehn, Stephanie Schorge, Kai Lamottke, Felix Rosenow
BACKGROUND: Temporal lobe epilepsy is a common and frequently intractable seizure disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of genes controlling neurotransmitter signalling, ion channels, synaptic structure, neuronal death, gliosis, and inflammation. Identification of mechanisms coordinating gene networks in patients with temporal lobe epilepsy will help to identify novel therapeutic targets and biomarkers. MicroRNAs (miRNAs) are a family of small non-coding RNAs that control the expression levels of multiple proteins by decreasing mRNA stability and translation, and could therefore be key regulatory mechanisms and therapeutic targets in epilepsy...
December 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839652/diagnosis-and-clinical-features-of-common-optic-neuropathies
#16
REVIEW
Valérie Biousse, Nancy J Newman
Disorders of the optic nerves (optic neuropathies) are some of the most common causes of visual loss, and can present in isolation or with associated neurological or systemic symptoms and signs. Several optic neuropathies-especially inflammatory optic neuropathies-are associated with neurological disorders and thus are often diagnosed and treated by neurologists. The mechanisms underlying optic neuropathies are diverse and typically manifest with decreased visual acuity, altered colour vision, and abnormal visual field in the affected eye...
December 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839651/progression-characteristics-of-the-european-friedreich-s-ataxia-consortium-for-translational-studies-efacts-a-2-year-cohort-study
#17
Kathrin Reetz, Imis Dogan, Ralf-Dieter Hilgers, Paola Giunti, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodriguez de Rivera, Ludger Schöls, Thomas Klockgether, Katrin Bürk, Myriam Rai, Massimo Pandolfo, Jörg B Schulz
BACKGROUND: The European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) is a prospective international registry investigating the natural history of Friedreich's ataxia. We used data from EFACTS to assess disease progression and the predictive value of disease-related factors on progression, and estimated sample sizes for interventional randomised clinical trials. METHODS: We enrolled patients with genetically confirmed Friedreich's ataxia from 11 European study sites in Austria, Belgium, France, Germany, Italy, Spain, and the UK...
December 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839650/impaired-consciousness-in-patients-with-absence-seizures-investigated-by-functional-mri-eeg-and-behavioural-measures-a-cross-sectional-study
#18
Jennifer N Guo, Robert Kim, Yu Chen, Michiro Negishi, Stephen Jhun, Sarah Weiss, Jun Hwan Ryu, Xiaoxiao Bai, Wendy Xiao, Erin Feeney, Jorge Rodriguez-Fernandez, Hetal Mistry, Vincenzo Crunelli, Michael J Crowley, Linda C Mayes, R Todd Constable, Hal Blumenfeld
BACKGROUND: The neural underpinnings of impaired consciousness and of the variable severity of behavioural deficits from one absence seizure to the next are not well understood. We aimed to measure functional MRI (fMRI) and electroencephalography (EEG) changes in absence seizures with impaired task performance compared with seizures in which performance was spared. METHODS: In this cross-sectional study done at the Yale School of Medicine, CT, USA, we recruited patients from 59 paediatric neurology practices in the USA...
December 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839649/news-in-brief
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27839648/kathrin-reetz
#20
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Lancet Neurology
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