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Lancet Neurology

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https://www.readbyqxmd.com/read/30563778/safety-and-efficacy-of-pridopidine-in-patients-with-huntington-s-disease-pride-hd-a-phase-2-randomised-placebo-controlled-multicentre-dose-ranging-study
#1
Ralf Reilmann, Andrew McGarry, Igor D Grachev, Juha-Matti Savola, Beth Borowsky, Eli Eyal, Nicholas Gross, Douglas Langbehn, Robin Schubert, Anna Teige Wickenberg, Spyros Papapetropoulos, Michael Hayden, Ferdinando Squitieri, Karl Kieburtz, G Bernhard Landwehrmeyer
BACKGROUND: Previous trials have shown that pridopidine might reduce motor impairment in patients with Huntington's disease. The aim of this study was to ascertain whether higher doses of pridopidine than previously tested reduce motor symptoms in a dose-dependent manner while maintaining acceptable safety and tolerability. METHODS: PRIDE-HD was a randomised, placebo-controlled, phase 2, dose-ranging study in adults (aged ≥21 years) with Huntington's disease at outpatient clinics in 53 sites across 12 countries (Australia, Austria, Canada, Denmark, France, Germany, Italy, Poland, Russia, the Netherlands, the UK, and the USA)...
December 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30563777/the-hunt-for-better-treatments-for-huntington-s-disease
#2
Roger Barker, Sarah L Mason
No abstract text is available yet for this article.
December 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30554829/evidence-for-treatment-of-spasticity-in-motor-neuron-disease
#3
Marianne de Visser
No abstract text is available yet for this article.
December 13, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30554828/safety-and-efficacy-of-nabiximols-on-spasticity-symptoms-in-patients-with-motor-neuron-disease-canals-a-multicentre-double-blind-randomised-placebo-controlled-phase-2-trial
#4
Nilo Riva, Gabriele Mora, Gianni Sorarù, Christian Lunetta, Ottavia E Ferraro, Yuri Falzone, Letizia Leocani, Raffaella Fazio, Mauro Comola, Giancarlo Comi
BACKGROUND: Spasticity is a major determinant of disability and decline in quality of life in patients with motor neuron disease. Cannabinoids have been approved for symptomatic treatment of spasticity in multiple sclerosis. We investigated whether cannabinoids might also reduce spasticity in patients with motor neuron disease. METHODS: We did an investigator-initiated, randomised, double-blind, placebo-controlled, phase 2 clinical trial at four tertiary motor neuron disease centres in Italy...
December 13, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30497967/global-burden-of-traumatic-brain-and-spinal-cord-injury
#5
Jetan H Badhiwala, Jefferson R Wilson, Michael G Fehlings
No abstract text is available yet for this article.
November 26, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30497966/statistics-on-the-burden-of-dementia-need-for-stronger-data
#6
Lenore J Launer
No abstract text is available yet for this article.
November 26, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30497965/global-regional-and-national-burden-of-traumatic-brain-injury-and-spinal-cord-injury-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#7
(no author information available yet)
BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury...
November 26, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30497964/global-regional-and-national-burden-of-alzheimer-s-disease-and-other-dementias-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#8
(no author information available yet)
BACKGROUND: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding of the dementia disease burden. We aimed to present the first detailed analysis of the global prevalence, mortality, and overall burden of dementia as captured by the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, and highlight the most important messages for clinicians and neurologists...
November 26, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30470609/clinical-challenges-and-future-therapeutic-approaches-for-neuronal-ceroid-lipofuscinosis
#9
REVIEW
Sara E Mole, Glenn Anderson, Heather A Band, Samuel F Berkovic, Jonathan D Cooper, Sophia-Martha Kleine Holthaus, Tristan R McKay, Diego L Medina, Ahad A Rahim, Angela Schulz, Alexander J Smith
Treatment of the neuronal ceroid lipofuscinoses, also known as Batten disease, is at the start of a new era because of diagnostic and therapeutic advances relevant to this group of inherited neurodegenerative and life-limiting disorders that affect children. Diagnosis has improved with the use of comprehensive DNA-based tests that simultaneously screen for many genes. The identification of disease-causing mutations in 13 genes provides a basis for understanding the molecular mechanisms underlying neuronal ceroid lipofuscinoses, and for the development of targeted therapies...
November 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30470608/rewiring-public-understanding-of-neurological-disorders
#10
Ashley Cooper
No abstract text is available yet for this article.
November 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30470607/individuality-rooted-in-the-brain-s-development
#11
Sophie Woolven
No abstract text is available yet for this article.
November 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30466863/correction-to-lancet-neurol-2018-17-1098-108
#12
(no author information available yet)
No abstract text is available yet for this article.
November 19, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30447972/towards-faster-studies-of-neonatal-encephalopathy
#13
Alistair J Gunn, Malcolm Battin
No abstract text is available yet for this article.
November 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30447971/-no-actually-it-is-not-a-headache
#14
Jules Morgan
No abstract text is available yet for this article.
November 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30447970/competing-to-raise-awareness-of-rare-diseases
#15
Agata Polizzi, Amalia Egle Gentile, Domenica Taruscio
No abstract text is available yet for this article.
November 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30447969/magnetic-resonance-spectroscopy-assessment-of-brain-injury-after-moderate-hypothermia-in-neonatal-encephalopathy-a-prospective-multicentre-cohort-study
#16
Peter J Lally, Paolo Montaldo, Vânia Oliveira, Aung Soe, Ravi Swamy, Paul Bassett, Josephine Mendoza, Gaurav Atreja, Ujwal Kariholu, Santosh Pattnayak, Palaniappan Sashikumar, Helen Harizaj, Martin Mitchell, Vijayakumar Ganesh, Sundeep Harigopal, Jennifer Dixon, Philip English, Paul Clarke, Priya Muthukumar, Prakash Satodia, Sarah Wayte, Laurence J Abernethy, Kiran Yajamanyam, Alan Bainbridge, David Price, Angela Huertas, David J Sharp, Vaneet Kalra, Sanjay Chawla, Seetha Shankaran, Sudhin Thayyil
BACKGROUND: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy. METHODS: We did a prospective multicentre cohort study across eight neonatal intensive care units in the UK and USA, recruiting term and near-term neonates who received therapeutic hypothermia for neonatal encephalopathy...
November 14, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30442568/bryan-traynor-serious-science-from-a-funny-fellow
#17
Ruth Williams
No abstract text is available yet for this article.
November 12, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30415935/the-rise-of-neurology-in-haiti
#18
Jacquelyn Corley
No abstract text is available yet for this article.
November 8, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30415934/timing-of-anticoagulation-after-recent-ischaemic-stroke-in-patients-with-atrial-fibrillation
#19
REVIEW
David J Seiffge, David J Werring, Maurizio Paciaroni, Jesse Dawson, Steven Warach, Truman J Milling, Stefan T Engelter, Urs Fischer, Bo Norrving
BACKGROUND: About 13-26% of all acute ischaemic strokes are related to non-valvular atrial fibrillation, the most common cardiac arrhythmia globally. Deciding when to initiate oral anticoagulation in patients with non-valvular atrial fibrillation is a longstanding, common, and unresolved clinical challenge. Although the risk of early recurrent ischaemic stroke is high in this population, early oral anticoagulation is suspected to increase the risk of potentially harmful intracranial haemorrhage, including haemorrhagic transformation of the infarct...
November 8, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30413385/penumbral-imaging-and-functional-outcome-in-patients-with-anterior-circulation-ischaemic-stroke-treated-with-endovascular-thrombectomy-versus-medical-therapy-a-meta-analysis-of-individual-patient-level-data
#20
Bruce C V Campbell, Charles B L M Majoie, Gregory W Albers, Bijoy K Menon, Nawaf Yassi, Gagan Sharma, Wim H van Zwam, Robert J van Oostenbrugge, Andrew M Demchuk, Francis Guillemin, Philip White, Antoni Dávalos, Aad van der Lugt, Kenneth S Butcher, Aboubaker Cherifi, Henk A Marquering, Geoffrey Cloud, Juan M Macho Fernández, Jeremy Madigan, Catherine Oppenheim, Geoffrey A Donnan, Yvo B W E M Roos, Jai Shankar, Hester Lingsma, Alain Bonafé, Hélène Raoult, María Hernández-Pérez, Aditya Bharatha, Reza Jahan, Olav Jansen, Sébastien Richard, Elad I Levy, Olvert A Berkhemer, Marc Soudant, Lucia Aja, Stephen M Davis, Timo Krings, Marie Tisserand, Luis San Román, Alejandro Tomasello, Debbie Beumer, Scott Brown, David S Liebeskind, Serge Bracard, Keith W Muir, Diederik W J Dippel, Mayank Goyal, Jeffrey L Saver, Tudor G Jovin, Michael D Hill, Peter J Mitchell
BACKGROUND: CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome. METHODS: In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1, 2010, to May 31, 2017...
November 6, 2018: Lancet Neurology
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