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Lancet Neurology

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https://www.readbyqxmd.com/read/28916420/sarah-tabrizi-timed-to-perfection
#1
Adrian Burton
No abstract text is available yet for this article.
September 12, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28919059/rates-of-hippocampal-atrophy-and-presence-of-post-mortem-tdp-43-in-patients-with-alzheimer-s-disease-a-longitudinal-retrospective-study
#2
Keith A Josephs, Dennis W Dickson, Nirubol Tosakulwong, Stephen D Weigand, Melissa E Murray, Leonard Petrucelli, Amanda M Liesinger, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Joseph E Parisi, Ronald C Petersen, Clifford R Jack, Jennifer L Whitwell
BACKGROUND: Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. We aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. METHODS: In this longitudinal retrospective study, we analysed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012, and who had been recruited into the Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic Alzheimer's Disease Patient Registry, or the Mayo Clinic Study of Aging...
September 11, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28843476/corrections
#3
(no author information available yet)
No abstract text is available yet for this article.
August 23, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28826869/phillip-low-the-autonomic-expert
#4
Jules Morgan
No abstract text is available yet for this article.
August 18, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28807669/t-cells-and-parkinson-s-disease
#5
R Lee Mosley, Howard E Gendelman
No abstract text is available yet for this article.
August 11, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28800868/nor-test-ing-tenecteplase-in-acute-ischaemic-stroke
#6
Craig S Anderson
No abstract text is available yet for this article.
August 8, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28780236/tenecteplase-versus-alteplase-for-management-of-acute-ischaemic-stroke-nor-test-a-phase-3-randomised-open-label-blinded-endpoint-trial
#7
Nicola Logallo, Vojtech Novotny, Jörg Assmus, Christopher E Kvistad, Lars Alteheld, Ole Morten Rønning, Bente Thommessen, Karl-Friedrich Amthor, Hege Ihle-Hansen, Martin Kurz, Håkon Tobro, Kamaljit Kaur, Magdalena Stankiewicz, Maria Carlsson, Åse Morsund, Titto Idicula, Anne Hege Aamodt, Christian Lund, Halvor Næss, Ulrike Waje-Andreassen, Lars Thomassen
BACKGROUND: Tenecteplase is a newer thrombolytic agent with some pharmacological advantages over alteplase. Previous phase 2 trials of tenecteplase in acute ischaemic stroke have shown promising results. We aimed to investigate the safety and efficacy of tenecteplase versus alteplase in patients with acute stroke who were eligible for intravenous thrombolysis. METHODS: This phase 3, randomised, open-label, blinded endpoint, superiority trial was done in 13 stroke units in Norway...
August 2, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28716372/corrections
#8
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713036/intracerebral-gene-therapy-for-mucopolysaccharidosis-type-iiib-syndrome
#9
Kim Hemsley, Adeline Lau
No abstract text is available yet for this article.
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28713034/marc-tardieu-the-interface-man
#10
Adrian Burton
No abstract text is available yet for this article.
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28688838/james-crichton-browne
#11
Ray Cavanaugh
No abstract text is available yet for this article.
July 5, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28684246/imaging-neuroinflammation-to-monitor-%C3%AE-synucleinopathy
#12
Yasuomi Ouchi
No abstract text is available yet for this article.
July 3, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28684245/assessment-of-neuroinflammation-in-patients-with-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-a-case-control-study
#13
Morten Gersel Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Eduardo Tolosa, Nicola Pavese
BACKGROUND: Findings from longitudinal follow-up studies in patients with idiopathic rapid-eye-movement sleep behaviour disorder (IRBD) have shown that most patients will eventually develop the synucleinopathies Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Neuroinflammation in the form of microglial activation is present in synucleinopathies and is a potential therapeutic target to halt or delay the neurodegenerative process. We aimed to investigate whether neuroinflammation is present in patients with IRBD and its possible relation to nigrostriatal dopamine function...
July 3, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28673545/eric-reiman-aiming-to-prevent-alzheimer-s-disease
#14
Tony Kirby
No abstract text is available yet for this article.
June 30, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28668373/corrections
#15
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28920890/exercise-in-patients-with-multiple-sclerosis
#16
REVIEW
Robert W Motl, Brian M Sandroff, Gert Kwakkel, Ulrik Dalgas, Anthony Feinstein, Christoph Heesen, Peter Feys, Alan J Thompson
Exercise can be a beneficial rehabilitation strategy for people with multiple sclerosis to manage symptoms, restore function, optimise quality of life, promote wellness, and boost participation in activities of daily living. However, this population typically engages in low levels of health-promoting physical activity compared with adults from the general population, a fact which has not changed in the past 25 years despite growing evidence of the benefits of exercise. To overcome this challenge, the main limitations to promoting exercise through the patient-clinician interaction must be addressed...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28920889/therapies-targeting-dna-and-rna-in-huntington-s-disease
#17
REVIEW
Edward J Wild, Sarah J Tabrizi
No disease-slowing treatment exists for Huntington's disease, but its monogenic inheritance makes it an appealing candidate for the development of therapies targeting processes close to its genetic cause. Huntington's disease is caused by CAG repeat expansions in the HTT gene, which encodes the huntingtin protein; development of therapies to target HTT transcription and the translation of its mRNA is therefore an area of intense investigation. Huntingtin-lowering strategies include antisense oligonucleotides and RNA interference targeting mRNA, and zinc finger transcriptional repressors and CRISPR-Cas9 methods aiming to reduce transcription by targeting DNA...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28920888/prediction-of-motor-recovery-after-stroke-advances-in-biomarkers
#18
REVIEW
Cathy M Stinear
Stroke remains a leading cause of adult disability, and the recovery of motor function after stroke is crucial for the patient to regain independence. However, making accurate predictions of a patient's motor recovery and outcome is difficult when based on clinical assessment alone. Clinical assessment of motor impairment within a few days of stroke can help to predict subsequent recovery, while neurophysiological and neuroimaging biomarkers of corticomotor structure and function can help to predict both motor recovery and motor outcome after stroke...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28920887/the-chronic-and-evolving-neurological-consequences-of-traumatic-brain-injury
#19
REVIEW
Lindsay Wilson, William Stewart, Kristen Dams-O'Connor, Ramon Diaz-Arrastia, Lindsay Horton, David K Menon, Suzanne Polinder
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing. Research on the long-term consequences emphasises that, for many patients, TBI should be conceptualised as a chronic health condition. Evidence suggests that functional outcomes after TBI can show improvement or deterioration up to two decades after injury, and rates of all-cause mortality remain elevated for many years. Furthermore, TBI represents a risk factor for a variety of neurological illnesses, including epilepsy, stroke, and neurodegenerative disease...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28920886/retinal-layer-segmentation-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#20
Axel Petzold, Laura J Balcer, Peter A Calabresi, Fiona Costello, Teresa C Frohman, Elliot M Frohman, Elena H Martinez-Lapiscina, Ari J Green, Randy Kardon, Olivier Outteryck, Friedemann Paul, Sven Schippling, Patrik Vermersch, Pablo Villoslada, Lisanne J Balk
BACKGROUND: Structural retinal imaging biomarkers are important for early recognition and monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction of spectral domain optical coherence tomography (SD-OCT), supervised automated segmentation of individual retinal layers is possible. We aimed to investigate which retinal layers show atrophy associated with neurodegeneration in multiple sclerosis when measured with SD-OCT. METHODS: In this systematic review and meta-analysis, we searched for studies in which SD-OCT was used to look at the retina in people with multiple sclerosis with or without optic neuritis in PubMed, Web of Science, and Google Scholar between Nov 22, 1991, and April 19, 2016...
October 2017: Lancet Neurology
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