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Journal of Surgical Research

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https://www.readbyqxmd.com/read/27712829/thoracoabdominal-aortic-aneurysm-repair-big-case-big-risk-big-center
#1
Faisal G Bakaeen, Eric E Roselli, Douglas R Johnston, Edward G Soltesz, Michael Z Tong, Lars G Svensson
No abstract text is available yet for this article.
September 28, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884351/in%C3%A2-vivo-imaging-of-antioxidant-response-element-activity-during-liver-regeneration-after-partial-hepatectomy
#2
Patrick Hamid Alizai, Lea Bertram, Athanassios Fragoulis, Christoph J Wruck, Daniela C Kroy, Uwe Klinge, Ulf P Neumann, Maximilian Schmeding
BACKGROUND: The nuclear factor-erythroid 2-related factor 2 (Nrf2) -antioxidant response element (ARE) pathway is important for the regulation of antioxidative stress response and detoxification. To activate the expression of its target genes, such as heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase (quinone) 1 (NQO1), Nrf2 binds to the ARE within the promoter region of these genes. Partial hepatectomy and consecutive liver regeneration lead to oxidative stress with activation of the Nrf2-ARE pathway...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884350/roux-en-y-gastric-bypass-augments-the-feeding-responses-evoked-by-gastrin-releasing-peptides
#3
Martha C Washington, Thaer R Mhalhal, Tanisha Johnson-Rouse, Jose Berger, John Heath, Randy Seeley, Ayman I Sayegh
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is the most effective method for the treatment of obesity, and metabolic disease RYGB may reduce body weight by altering the feeding responses evoked by the short-term satiety peptides. MATERIALS AND METHODS: Here, we measured meal size (MS, chow), intermeal interval (IMI) length, and satiety ratio (SR, IMI/MS; food consumed per a unit of time) by the small and the large forms of gastrin-releasing peptide (GRP) in rats, GRP-10 and GRP-29 (0, 0...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884349/endotoxemia-accelerates-diaphragm-dysfunction-in-ventilated-rabbits
#4
Yi Yang, Tao Yu, Chun Pan, Federico Longhini, Ling Liu, Yingzi Huang, Fengmei Guo, Haibo Qiu
BACKGROUND: Ventilators may induce diaphragm dysfunction, and most of the septic population who are admitted to the intensive care unit require mechanical ventilation. However, there is no evidence that sepsis accelerates the onset of ventilator-induced diaphragm dysfunction or affects the microcirculation. Our study investigated whether lipopolysaccharide (LPS)-induced endotoxemia accelerated diaphragm dysfunction in ventilated rabbits by evaluating microcirculation, lipid accumulation, and diaphragm contractility...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884348/prognostic-relevance-of-hematological-profile-before-resection-for-colorectal-liver-metastases
#5
Ulf Kulik, Harald Schrem, Hueseyin Bektas, Juergen Klempnauer, Frank Lehner
BACKGROUND: Although alterations of hematological profile and especially elevated platelet counts were reported to influence survival in primary colorectal cancer, its prognostic relevance before the surgical treatment of colorectal liver metastases (CLM) is mainly unclear. Therefore, the aim of this study was to analyze the impact of these factors on overall survival following liver resection of CLM. MATERIALS AND METHODS: The surgical treatment of primary CLM between 1994 and 2012 in 983 patients was retrospectively analyzed using univariable and multivariable Cox regression models...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884347/fabrication-of-three-dimensional-scan-to-print-ear-model-for-microtia-reconstruction
#6
Byoungjun Jeon, Chiwon Lee, Myungjoon Kim, Tae Hyun Choi, Sungwan Kim, Sukwha Kim
BACKGROUND: Microtia is a congenital deformity of the external ear that occurs in 1 of every 5000 births. Microtia reconstruction using traditional two-dimensional templates does not provide highly detailed ear shapes. Here, we describe the feasibility of using a three-dimensional (3D) ear model as a reference. MATERIALS AND METHODS: Seven children aged from 11 to 16 (6 grade III and 1 grade II microtia) were recruited from Seoul National University Children's Hospital, Korea...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884346/survival-outcomes-of-geriatric-patients-with-clinically-resectable-gastric-cancer-to-operate-or-not
#7
Keng-Hao Liu, Chia-Yen Hung, Chang-Hsien Lu, Jun-Te Hsu, Ta-Sen Yeh, Yung-Chang Lin, Yu-Shin Hung, Wen-Chi Chou
BACKGROUND: Approximately, 50% of all gastric cancer patients are aged >70 y. Although curative surgery is the treatment of choice, many geriatric patients die of surgical complications. Therefore, we aimed to evaluate the impact of radical surgery on the survival outcome of geriatric patients with resectable gastric cancers. METHODS: About 488 patients diagnosed with resectable gastric cancers, aged ≥70 y, between January 2007 and December 2012 at Chang Gung Memorial Hospital (CGMH) Linkou branch were included in this study...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884345/wound-edge-protection-devices-in-gastrointestinal-surgery-a-meta-analysis
#8
Qiang Chen, Lei Chen, Gang Chen, Yuwei Pu, Chungen Xing
BACKGROUND: The role of wound-edge protection devices (WEPDs) in wound infection prevention is still controversial. The aim of this meta-analysis was to assess the protective efficiency of WEPDs in gastrointestinal surgery in a pooled analysis of randomized controlled trials. MATERIALS AND METHODS: A variety of sources were searched for randomized controlled trials evaluating the protective efficiency of WEPDs in gastrointestinal surgery. Subgroup analysis and meta-regressions were conducted to investigate the possible influence of the type of WEPD on the size of intervention effect...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884344/do-resident-s-leadership-skills-relate-to-ratings-of-technical-skill
#9
Samantha J Gannon, Katherine E Law, Rebecca D Ray, Jay N Nathwani, Shannon M DiMarco, Anne-Lise D D'Angelo, Carla M Pugh
BACKGROUND: This study sought to compare general surgery research residents' survey information regarding self-efficacy ratings to their observed performance during a simulated small bowel repair. Their observed performance ratings were based on their leadership skills in directing their assistant. METHODS: Participants were given 15 min to perform a bowel repair using bovine intestines with standardized injuries. Operative assistants were assigned to help assist with the repair...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884343/increased-tolerance-to-stress-in-cardiac-expressed-gain-of-function-of-adenosine-triphosphate-sensitive-potassium-channel-subunit-kir6-1
#10
Matthew C Henn, M Burhan Janjua, Haixia Zhang, Evelyn M Kanter, Carol M Makepeace, Richard B Schuessler, Colin G Nichols, Jennifer S Lawton
BACKGROUND: The adenosine triphosphate-sensitive potassium (KATP) channel opener diazoxide (DZX) prevents myocyte volume derangement and reduced contractility secondary to stress. KATP channels are composed of pore-forming (Kir6.1 or Kir6.2) and regulatory (sulfonylurea receptor, SUR1 or SUR2) subunits. Gain of function (GOF) of Kir6.1 subunits has been implicated in cardiac pathology in Cantu syndrome in humans (cardiomegaly, lymphedema, and pericardial effusions). We hypothesized that GOF of Kir6...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884342/optimizing-neurogenic-potential-of-enteric-neurospheres-for-treatment-of-neurointestinal-diseases
#11
Lily S Cheng, Hannah K Graham, Wei Hua Pan, Nandor Nagy, Alfonso Carreon-Rodriguez, Allan M Goldstein, Ryo Hotta
BACKGROUND: Enteric neurospheres derived from postnatal intestine represent a promising avenue for cell replacement therapy to treat Hirschsprung disease and other neurointestinal diseases. We describe a simple method to improve the neuronal yield of spontaneously formed gut-derived neurospheres. MATERIALS AND METHODS: Enteric neurospheres were formed from the small and large intestines of mouse and human subjects. Neurosphere size, neural crest cell content, cell migration, neuronal differentiation, and neuronal proliferation in culture were analyzed...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884341/propofol-inhibits-t-helper-cell-type-2-differentiation-by-inducing-apoptosis-via-activating-gamma-aminobutyric-acid-receptor
#12
Jingxia Meng, Xin Xin, Zhen Liu, Hao Li, Bo Huang, Yuguang Huang, Jing Zhao
BACKGROUND: Propofol has been shown to attenuate airway hyperresponsiveness in asthma patients. Our previous study showed that it may alleviate lung inflammation in a mouse model of asthma. Given the critical role of T-helper cell type-2 (Th2) differentiation in asthma pathology and the immunomodulatory role of the gamma-aminobutyric acid type A (GABAA) receptor, we hypothesized that propofol could alleviate asthma inflammation by inhibiting Th2 cell differentiation via the GABA receptor...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884340/use-of-an-experimental-model-to-evaluate-infection-resistance-of-meshes-in-abdominal-wall-surgery
#13
Ramón Pérez-Tanoira, C Lévano-Linares, Á Celdrán-Uriarte, M C Isea-Peña, M Sánchez De Molina, C García-Vasquez, J Esteban-Moreno
BACKGROUND: Staphylococcal species are the most common organisms causing prosthetic mesh infections, however, infections due to rapidly growing mycobacteria are increasing. This study evaluates the resistance of biomaterial for abdominal wall prostheses against the development of postoperative infection in a rat model. MATERIAL AND METHODS: In 75 rats, we intramuscularly implanted three different types of prostheses: (1) low-density polypropylene monofilament mesh (PMM), (2) high-density PMM, and (3) a composite prosthesis composed of low-density PMM and a nonporous hydrophilic film...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884339/dose-dependent-mortality-and-organ-injury-in-a-cecal-slurry-peritonitis-model
#14
Min Ji Lee, Kyuseok Kim, You Hwan Jo, Jae Hyuk Lee, Ji Eun Hwang
BACKGROUND: The cecal slurry model was introduced as an alternative method for creating an animal sepsis model. This study was performed to evaluate dose-dependent mortality and organ injury in a sepsis model of cecal slurry peritonitis. MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into 5.0, 7.5, 10, or 15 mL/kg groups, according to the volume of cecal slurry administered into the peritoneal cavity. In the survival study, rats were observed for 14 d after sepsis induction...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884338/the-effect-of-local-hyperglycemia-on-skin-cells-in%C3%A2-vitro-and-on-wound-healing-in-euglycemic-rats
#15
Carla R Kruse, Mansher Singh, Jens A Sørensen, Elof Eriksson, Kristo Nuutila
BACKGROUND: Multiple previous studies have established that high systemic blood glucose concentration impairs skin wound healing. However, the effects of local hyperglycemia on wound healing are not well defined. Comprehensive animal studies and in vitro studies using both fibroblasts and keratinocytes are lacking. MATERIALS AND METHODS: Primary keratinocytes and fibroblasts were isolated from discarded human tissue, cultured under different concentrations of glucose, and the effect on cell function was examined...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884337/using-community-outreach-to-explore-health-related-beliefs-and-improve-surgeon-patient-engagement
#16
Rebecca L Hoffman, Brenda Bryant, Steve R Allen, Major K Lee, Cary B Aarons, Rachel R Kelz
BACKGROUND: Fostering surgeon engagement in community outreach was recently identified as a major priority toward reducing health care disparities in surgery. We aimed to increase surgeon engagement in the local community, understand prevalent beliefs, and identify educational opportunities in the local community regarding cancer screening and treatment using community outreach. MATERIALS AND METHODS: In collaboration with the university's cancer center, the medical student surgical interest group, surgical faculty, and residents developed a community outreach program...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884336/predictive-value-of-clinical-scoring-and-simplified-gait-analysis-for-acetabulum-fractures
#17
Benedikt J Braun, Julian Wrona, Nils T Veith, Mika Rollman, Marcel Orth, Steven C Herath, Jörg H Holstein, Tim Pohlemann
BACKGROUND: Fractures of the acetabulum show a high, long-term complication rate. The aim of the present study was to determine the predictive value of clinical scoring and standardized, simplified gait analysis on the outcome after these fractures. METHODS: Forty-one patients with acetabular fractures treated between 2008 and 2013 and available, standardized video recorded aftercare were identified from a prospective database. A visual gait score was used to determine the patients walking abilities 6-m postoperatively...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884335/pneumonia-prevention-in-intubated-patients-given-sucralfate-versus-proton-pump-inhibitors-and-or-histamine-ii-receptor-blockers
#18
Gene A Grindlinger, Sarah B Cairo, Carole B Duperre
BACKGROUND: Ventilator-associated pneumonia (VAP) is a common cause of infectious morbidity and mortality in the intensive care unit (ICU). The type of stress-ulcer prophylaxis (SUP) given to ventilated patients may, in part, be responsible. We observed an increase in VAP as ventilator bundle compliance increased and a decrease in VAP when bundle compliance decreased. We reasoned that SUP which raises gastric pH such as proton-pump inhibitors (PPIs) and histamine II (H2) receptor antagonists as opposed to SUP which does not raise pH such as sucralfate (S) may be responsible and also may alter the causative bacteria...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884334/assessment-of-the-incidence-of-chronic-pain-and-discomfort-after-primary-inguinal-hernia-repair
#19
Hideyuki Takata, Takeshi Matsutani, Nobutoshi Hagiwara, Junji Ueda, Hiroki Arai, Yasuyuki Yokoyama, Tsutomu Nomura, Eiji Uchida
BACKGROUND: Chronic pain and discomfort is a notable complication after inguinal hernia repair. This study assesses the incidence and degree of chronic pain and discomfort after primary inguinal hernia repair performed in our hospital and aims to clarify its relationship to the type of mesh placement. MATERIALS AND METHODS: A retrospective analysis was conducted of 334 patients (378 lesions) who underwent primary inguinal hernia using the Lichtenstein (onlay mesh), Ultrapro Plug (UPP; onlay plus plug mesh), modified Kugel Patch (onlay and underlay mesh), or laparoscopic transabdominal preperitoneal (TAPP; underlay mesh) procedure...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27884333/c-spine-injury-and-mandibular-fractures-lifesaver-broken-in-two-spots
#20
Michael W Chu, Tahereh Soleimani, Tyler A Evans, Sarah I Fernandez, Leigh Spera, Carrie Klene, Ben L Zarzaur, Sunil S Tholpady
BACKGROUND: Trauma is a leading cause of injury and mortality and may involve mandibular fractures and cervical spine injuries. Manipulation of the spine during trauma protocols and operative treatment has the potential to cause serious spinal cord injuries. The purpose of this study was to identify risk factors associated with cervical spine injury (CSI) in patients with mandibular fractures. METHODS: The National Trauma Databank (2007-2010) was used to identify patients with mandibular fractures...
December 2016: Journal of Surgical Research
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