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Journal of Surgical Research

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https://www.readbyqxmd.com/read/28117092/then-we-all-fall-down-fall-mortality-by-trauma-center-level
#1
Daniel Roubik, Alan D Cook, Jeanette G Ward, Kristina M Chapple, Sheldon Teperman, Melvin E Stone, Brian Gross, Forrest O Moore
BACKGROUND: Ground-level falls (GLFs) are the predominant mechanism of injury in US trauma centers and accompany a spectrum of comorbidities, injury severity, and physiologic derangement. Trauma center levels define tiers of capability to treat injured patients. We hypothesized that risk-adjusted observed-to-expected mortality (O:E) by trauma center level would evaluate the degree to which need for care was met by provision of care. MATERIALS AND METHODS: This retrospective cohort study used National Trauma Data Bank files for 2007-2014...
January 6, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28095987/an-anatomic-risk-model-to-screen-post-endovascular-aneurysm-repair-patients-for-aneurysm-sac-enlargement
#2
Chien Yi M Png, Rami O Tadros, William E Beckerman, Daniel K Han, Melissa L Tardiff, Marielle R Torres, Michael L Marin, Peter L Faries
BACKGROUND: Follow-up computed tomography angiography (CTA) scans add considerable postimplantation costs to endovascular aneurysm repairs (EVARs) of abdominal aortic aneurysms (AAAs). By building a risk model, we hope to identify patients at low risk for aneurysm sac enlargement to minimize unnecessary CTAs. METHODS: 895 consecutive patients who underwent EVAR for AAA were reviewed, of which 556 met inclusion criteria. A Probit model was created for aneurysm sac enlargement, with preoperative aneurysm morphology, patient demographics, and operative details as variables...
December 27, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993221/exendin-4-a-glucagon-like-peptide-1-analogue-accelerates-diabetic-wound-healing
#3
Jun-Neng Roan, Han-Ni Cheng, Chao-Chung Young, Chi-Ju Lee, Ming-Long Yeh, Chwan-Yau Luo, Yau-Sheng Tsai, Chen-Fuh Lam
BACKGROUND: Diabetes disregulates inflammatory responses and impairs vascular function in wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with pleiotropic vascular protective and anti-inflammatory effects. The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated. MATERIALS AND METHODS: Excisional wounds were created on the dorsum of streptozotocin-induced diabetic rats, which received placebo or Glp-1 analogue exendin-4 (Ex4; 0...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993220/intestinal-alkaline-phosphatase-decreases-intraperitoneal-adhesion-formation
#4
Sanjiv K Hyoju, Sara Morrison, Sarah Gul, Mohammad Hadi Gharedaghi, Mohamed Mussa, Mehran Najibi, Konstantinos P Economopoulos, Sulaiman R Hamarneh, Richard A Hodin
BACKGROUND: Damage to the peritoneum initiates an inflammatory response leading to the formation of adhesions, which subsequently cause significant morbidity in some patients. Intestinal alkaline phosphatase (IAP) is a gut enzyme capable of detoxifying various inflammatory mediators such as lipopolysaccharide, lipoteichoic acid, CpG DNA, and adenosine triphosphate. In this study, we aimed to examine the anti-inflammatory effects of IAP on postoperative adhesions in mice. METHODS: C57BL/6 mice were subjected to a midline laparotomy and then six musculoperitoneal buttons (MPBs) were created by pinching and ligating the peritoneum and underlying muscle...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993219/behavior-of-a-new-long-chain-cyanoacrylate-tissue-adhesive-used-for-mesh-fixation-in-hernia-repair
#5
Juan M Bellón, Mar Fernández-Gutiérrez, Marta Rodríguez, Paloma Pérez-López, Bárbara Pérez-Köhler, Andree Kühnhardt, Gemma Pascual, Julio San Román
BACKGROUND: Synthetic tissue adhesives (TA) are sometimes used in hernia repair surgery. This study compares the use of a new, noncommercial, long-chain cyanoacrylate (n-octyl) TA and Ifabond for mesh fixation. MATERIALS AND METHODS: In two implant models in the rabbit, expanded polytetrafluorethylene meshes were fixed to the parietal peritoneum using a TA or tacks (intraperitoneal model), or polypropylene meshes used to repair partial abdominal wall defects were fixed with a TA or sutures (extraperitoneal model)...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993218/magnetic-compression-anastomosis-for-enteroenterostomy-under-peritonitis-conditions-in-dogs
#6
Hongke Zhang, Kai Tan, Chao Fan, Jingwei Du, Jiangbin Li, Tao Yang, Yi Lv, Xilin Du
BACKGROUND: The risk of complications and mortality are high after enteroenterostomy in severe peritonitic conditions. Magnetic compression anastomosis (MCA) is a sutureless technique of high efficacy and safety. The purpose of this study was to compare the efficacy of MCA for enteroenterostomy with stapled and hand-sewn techniques under peritonitic conditions. METHODS: The peritonitic conditions were created by puncturing the colon with a circular blade in 27 mongrel dogs...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993217/comparing-industry-compensation-of-cardiothoracic-surgeons-and-interventional-cardiologists
#7
Joshua Parreco, Elie Donath, Robert Kozol, Cristiano Faber
BACKGROUND: The purpose of this study was to compare payment trends between cardiothoracic surgeons and interventional cardiologists using the Open Payments website made available for the public by the Center for Medicare and Medicaid Services. MATERIAL AND METHODS: Data were extracted from the second release of the Open Payments database, which includes payments made between August 1, 2013 and December 31, 2014. Total payments to individual physicians were aggregated based on specialty, region of the country, and payment type...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993216/vascular-endothelial-growth-factor-expression-is-an-independent-poor-prognostic-factor-for-human-epidermal-growth-factor-receptor-2-positive-gastric-cancer
#8
Jun-Te Hsu, Tai-Di Chen, Huei-Chieh Chuang, Shih-Chiang Huang, Puo-Hsien Le, Tsung-Hsing Chen, Chun-Jung Lin, Ta-Sen Yeh
BACKGROUND: The positive expression of human epidermal growth factor receptor 2 (HER-2) is phenotypically associated with differentiated gastric cancer (GC) and is a prognostic factor for resectable GC. The aim of this study was to explore the clinical significance of vascular endothelial growth factor (VEGF), protein kinase B, and p38 mitogen-activated protein kinase (MAPK) regarding outcome in patients with HER-2 positive GC, and to analyze the relationship between these molecules and clinicopathologic parameters...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993215/anti-pd-l1-peptide-improves-survival-in-sepsis
#9
Yuichiro Shindo, Jacquelyn S McDonough, Katherine C Chang, Murali Ramachandra, Pottayil G Sasikumar, Richard S Hotchkiss
BACKGROUND: Sepsis remains a leading cause of death in most intensive care units. Many deaths in sepsis are due to nosocomial infections in patients who have entered the immunosuppressive phase of the disorder. One cause of immunosuppression in sepsis is T-cell exhaustion mediated by programmed cell death-1 (PD-1) interaction with its ligand (PD-L1). Studies demonstrated that blocking the interaction of PD-1 with PD-L1 with knockout mice or inhibitory antibodies reversed T-cell dysfunction and improved sepsis survival...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993214/predictors-of-residual-disease-after-unplanned-excision-of-soft-tissue-sarcomas
#10
Alicia A Gingrich, Alexandra Elias, Chia-Yuan Michael Lee, Yves-Paul N Nakache, Chin-Shang Li, Dhruvil R Shah, Robert D Boutin, Robert J Canter
BACKGROUND: Unplanned excision of soft tissue sarcomas (STS) is an important quality of care issue given the morbidity related to tumor bed excision. Since not all patients harbor residual disease at the time of reexcision, we sought to determine predictors of residual STS following unplanned excision. METHODS: We identified 76 patients from a prospective database (January 1, 2008-September 30, 2014) who received a diagnosis of primary STS following unplanned excision on the trunk or extremities...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993213/an-ex%C3%A2-vivo-comparison-of-adenosine-and-lidocaine-solution-and-university-of-wisconsin-solution-for-hypothermic-machine-perfusion-of-porcine-kidneys-potential-for-development
#11
Karim Hamaoui, Adeel Aftab, Sally Gowers, Martyn Boutelle, Terry Cook, Donna Rudd, Geoffrey P Dobson, Vassilios Papalois
BACKGROUND: The optimal hypothermic machine perfusion (HMP) solution has not yet been developed. An adenosine and lidocaine (AL) solution has been shown to be protective in cardiac preservation. The aim of the present study was to examine a modified AL solution with low Ca(2+), 16 mM Mg(2+), and 4% albumin on kidney preservation compared with University Wisconsin solution (UW). METHODS: Twenty donation of organs after cardiac death porcine kidneys underwent HMP for 10 h (AL, n = 10; UW, n = 10) and then 2 h of normothermic reperfusion...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993212/criteria-derived-from-serum-markers-can-precisely-evaluate-axillary-status-in-breast-cancer-patients
#12
Hangyu Wan, Zhenggui Du, Quanyi Long, Qing Lü, Hongjiang Li
BACKGROUND: A noninvasive method to confirm the presence of lymph node metastases (LNM) in breast cancer patients is lacking. This study aimed to identify markers from peripheral blood that have diagnostic value in evaluating axillary LNM. METHODS: We tested 26 factors in serum from 57 patients with resectable breast cancer by the Luminex assay. Differences between node-negative and node-positive patients were assessed. The diagnostic value of the factors was determined by further analyses and a validation test...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993211/trauma-patients-who-present-in-a-delayed-fashion-a-unique-and-challenging-population
#13
Mary J Kao, Hector Nunez, Sean F Monaghan, Daithi S Heffernan, Charles A Adams, Stephanie N Lueckel, Andrew H Stephen
BACKGROUND: A proportion of trauma patients present for evaluation in a delayed fashion after injury, likely due to a variety of medical and nonmedical reasons. There has been little investigation into the characteristics and outcomes of trauma patients who present delayed. We hypothesize that trauma patients who present in a delayed fashion are a unique population at risk of increased trauma-related complications. MATERIALS AND METHODS: This was a retrospective review from 2010-2015 at a Level I trauma center...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993210/recombinant-human-lubricin-for-prevention-of-postoperative-intra-abdominal-adhesions-in-a-rat-model
#14
Jaewook Oh, Kean G Kuan, Leong U Tiong, Markus I Trochsler, Gregory Jay, Tannin A Schmidt, Harry Barnett, Guy J Maddern
BACKGROUND: Postoperative intra-abdominal adhesions are a major cause of morbidity and mortality and contribute to a heavy burden on health care resources. At present, numerous introduced adhesion prevention products have demonstrated some benefit but none are consistently effective. The aim of this study was to examine the effectiveness of recombinant human lubricin in preventing intra-abdominal adhesion formation. MATERIALS AND METHODS: A total of 62 male Wistar Albino rats were randomly assigned to the study...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993209/enhanced-serotonin-signaling-stimulates-ordered-intestinal-mucosal-growth
#15
John J Tackett, Neeru Gandotra, Michaela C Bamdad, Eleanor D Muise, Robert A Cowles
BACKGROUND: Significant quantities of serotonin (5-hydroxytryptamine; 5-HT) are found in the intestine, and studies have demonstrated that 5-HT can stimulate enterocyte cell division, suggesting regulatory roles in mucosal homeostasis and intestinal adaptation. We hypothesized that excess enteric 5-HT signaling enhances mucosal growth without changing intestinal villous cellular makeup. METHODS: Mice lacking the serotonin reuptake transporter (SERT) and wild-type littermates (WTLM) were euthanized and their ileum analyzed...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993208/the-price-of-surgery-markup-of-operative-procedures-in-the-united-states
#16
Faiz Gani, Martin A Makary, Timothy M Pawlik
BACKGROUND: Despite cost containment efforts, the price for surgery is not subject to any regulations. We sought to characterize and compare variability in pricing for commonly performed major surgical procedures across the United States. METHODS: Medicare claims corresponding to eight major surgical procedures (aortic aneurysm repair, aortic valvuloplasty, carotid endartectomy, coronary artery bypass grafting, esophagectomy, pancreatectomy, liver resection, and colectomy) were identified using the Medicare Provider Utilization and Payment Data Physician and Other Supplier Public Use File for 2013...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993207/gallbladder-abnormalities-in-children-with-metachromatic-leukodystrophy
#17
Jina Kim, Zhifei Sun, Brian Ezekian, Gary R Schooler, Vinod K Prasad, Joanne Kurtzberg, Henry E Rice, Elisabeth T Tracy
BACKGROUND: Metachromatic leukodystrophy (MLD) is a lysosomal storage disease that leads to neurological deterioration and visceral involvement, including sulphatide deposition in the gallbladder wall. Using our institution's extensive experience in treating MLD, we examined the incidence of gallbladder abnormalities in the largest cohort of children with MLD to date. METHODS: We conducted a retrospective review of all children with MLD, adrenoleukodystrophy (ALD), or Krabbe disease who underwent hematopoietic stem cell transplantation (HSCT) at our institution between 1994 and 2015...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993206/local-and-systemic-th17-immune-response-associated-with-advanced-stage-colon-cancer
#18
Stephen P Sharp, Dorina Avram, Steven C Stain, Edward C Lee
BACKGROUND: Little is known about how the immunologic microenvironment changes during tumor progression and metastatic spread. Recently, murine models have shown the T-helper 17 (Th17) pathway to play an important role in promoting colorectal cancer (CRC). The purpose of this study was to compare cytokine profiles in the tumor microenvironment of CRC between local disease (stages I/II) and advanced disease (stages III/IV), and to determine whether these changes were manifest in the systemic circulation of patients with advanced disease...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993205/trauma-experts-versus-pediatric-experts-comparison-of-outcomes-in-pediatric-penetrating-injuries
#19
Shin Miyata, Jayun Cho, Olga Lebedevskiy, Kazuhide Matsushima, Esther Bae, David W Bliss
BACKGROUND: While pediatric trauma centers (PTCs) can uniquely care for pediatric patients, adult trauma centers (ATCs) may be more accessible. Evidence is scarce regarding outcomes of pediatric patients with penetrating trauma treated at PTCs versus ATCs. MATERIALS AND METHODS: We performed a retrospective study using the National Trauma Data Bank to identify pediatric patients aged ≤18 y with penetrating injuries from 2007 to 2012, treated at stand-alone PTCs or ATCs...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993204/massive-transfusion-in-pediatric-trauma-analysis-of-the-national-trauma-databank
#20
Michelle C Shroyer, Russell L Griffin, Vincent E Mortellaro, Robert T Russell
BACKGROUND: Massive transfusion (MT) in pediatric trauma has been described in combat populations and other single institutions studies. We aim to define the incidence of MT in a large US civilian pediatric trauma population, identify predictive parameters of MT, and the mortality associated with MT. METHODS: Data from the National Trauma Databank (2010-2012), a trauma registry maintained by the American College of Surgeons, were analyzed. We included pediatric trauma patients ≤14 y that underwent MT, as defined by 40 mL/kg of blood products within the first 24 h after admission...
February 2017: Journal of Surgical Research
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