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Journal of Surgical Research

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https://www.readbyqxmd.com/read/28032567/protective-effects-of-syringin-against-lipopolysaccharide-induced-acute-lung-injury-in-mice
#1
Ao Zhang, Zhongmin Liu, Lulu Sheng, Hui Wu
BACKGROUND: Syringin, a major active substance isolated from Eleutherococcus senticosus, has been found to have anti-inflammatory effect. The aim of this study was to investigate the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. METHODS: We established an LPS-induced ALI model in mice. We also detected the lung wet-to-dry ratio, myeloperoxidase activity, and inflammatory cytokines tumor necrosis factor alpha, interleukin (IL)-1β, and IL-6 to estimate the index of lung injury in mice...
November 5, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032565/surgical-site-infection-after-stoma-closure-in-children-outcomes-and-predictors
#2
Dani O Gonzalez, Erica Ambeba, Peter C Minneci, Katherine J Deans, Benedict C Nwomeh
BACKGROUND: Surgical site infection (SSI) is a burdensome complication following intestinal stoma closure, with reported rates ranging from 0% to 40%. We aimed to identify risk factors for SSI in children undergoing stoma closure. MATERIALS AND METHODS: Using 2012-2014 NSQIP Pediatric data, we identified patients aged 0-18 years undergoing stoma closure. Demographic, clinical, and 30-day outcome characteristics between children with and without SSI were compared...
November 4, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032563/surgeon-not-technique-defines-outcomes-after-central-venous-port-insertion
#3
Audrey E Ertel, Zachary D McHenry, Vijay K Venkatesan, Dennis J Hanseman, Koffi Wima, Richard S Hoehn, Shimul A Shah, Daniel E Abbott
BACKGROUND: Although central venous access for port placement is common and relatively safe, complications and poor resource utilization occur. We hypothesized that despite the simplicity of port placement, surgeon and/or resident performance-rather than technique-is associated with clinical outcomes and operating room efficiency. MATERIALS AND METHODS: Medical records of 1200 patients who underwent port placement between 2012 and 2015 at our institution were retrospectively reviewed...
November 4, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032566/rabbit-model-provides-new-insights-in-liver-regeneration-after-transection-with-portal-vein-ligation
#4
Mingheng Liao, Tao Zhang, Haichuan Wang, Ying Liu, Minxun Lu, Jiwei Huang, Yong Zeng
BACKGROUND: The rabbit model of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has not been reported before. MATERIALS AND METHODS: New Zealand white rabbits were allocated to two protocols. Protocol 1 involved either liver parenchymal transection (LPT, n = 5) or portal vein ligation (PVL, n = 5). Protocol 2 involved the ligation of different portal vein branches combined with liver partition, including the LPT + 20% PVL group (n = 5; the caudate portal vein was ligated), the LPT + 50% PVL group (n = 5; the left portal vein was ligated), and the LPT + 70% PVL group (n = 10; both veins were ligated)...
November 2, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032564/wearing-lead-aprons-in-surgical-operating-rooms-ergonomic-injuries-evidenced-by-infrared-thermography
#5
Dominique Alexandre, Marc Prieto, Fabien Beaumont, Redha Taiar, Guillaume Polidori
BACKGROUND: The purpose of this study is to quantify the impact of the weight of radiation protection lead aprons on the discomfort and the fatigue of the medical staff within an operating room of interventional gastroenterology. To quantify this fatigue, we analyzed variations of the physiological parameters, including heart rate, blood pressure, and cutaneous temperature; we compared two situations: the first within the classic endoscopy department (without apron) and the second within the operating room with apron...
November 2, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032560/patients-experience-of-acute-unplanned-surgical-reoperation
#6
Maria Dillström, Kristofer Bjerså, My Engström
BACKGROUND: Undergoing surgery always involves various risks of complications, often depending on the type of surgery. Because of complications, a second surgical intervention, a reoperation, must occasionally be done, which in turn often causes an extended hospital stay, a longer recovery phase, greater suffering for the patient, and higher health care costs. Even though complications after general surgery are relatively common, little is known regarding patient experience of a reoperation...
October 26, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032559/bradykinin-stimulates-protein-kinase-d-mediated-colonic-myofibroblast-migration-via-cyclooxygenase-2-and-heat-shock-protein-27
#7
Eric Chu, Shyla Saini, Tiegang Liu, James Yoo
BACKGROUND: Inflammatory bowel disease is characterized by episodic intestinal injury and repair. Myofibroblasts are gastrointestinal tract stromal cells that regulate the reparative process and are known targets of inflammatory mediators including bradykinin (BK). However, the mechanisms through which inflammation regulates myofibroblast-induced wound healing remain incompletely understood. Here, we demonstrate, for the first time, that BK stimulates myofibroblast migration through protein kinase D (PKD)-mediated activation of the cyclooxygenase-2 (COX-2) and heat shock protein 27 (Hsp27) pathways...
October 20, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032558/early-learners-as-health-coaches-for-older-adults-preparing-for-surgery
#8
Jennifer A Kaplan, Zabecca Brinson, Rebecca Hofer, Patricia O'Sullivan, Anna Chang, Helen Horvath, George J Chang, Emily Finlayson
BACKGROUND: Few opportunities exist for early learners to engage in authentic roles on health care teams. In a geriatric optimization clinic for frail high-risk surgical patients, first-year medical and nurse practitioner students were integrated into an interprofessional team as health coaches. MATERIALS AND METHODS: Frail surgical patients with planned operations were referred to a new preoperative optimization clinic to see a geriatrician, occupational, and physical therapists and a nutritionist...
October 20, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032557/emotional-intelligence-in-surgery-is-associated-with-resident-job-satisfaction
#9
Robert H Hollis, Lauren M Theiss, Allison A Gullick, Joshua S Richman, Melanie S Morris, Jayleen M Grams, John R Porterfield, Daniel I Chu
BACKGROUND: Emotional intelligence (EI) has been associated with improved work performance and job satisfaction in several industries. We evaluated whether EI was associated with higher measures of work performance and job satisfaction in surgical residents. METHODS: We distributed the validated Trait EI Questionnaire and job satisfaction survey to all general surgery residents at a single institution in 2015. EI and job satisfaction scores were compared with resident performance using faculty evaluations of clinical competency-based surgical milestones and standardized test scores including the United States Medical Licensing Examination (USMLE) and American Board of Surgery In-Training Examination (ABSITE)...
October 20, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993221/exendin-4-a-glucagon-like-peptide-1-analogue-accelerates-diabetic-wound-healing
#10
Jun-Neng Roan, Han-Ni Cheng, Chao-Chung Young, Chi-Ju Lee, Ming-Long Yeh, Chwan-Yau Luo, Yau-Sheng Tsai, Chen-Fuh Lam
BACKGROUND: Diabetes disregulates inflammatory responses and impairs vascular function in wounds. Glucagon-like peptide-1 receptor (Glp-1R) agonists are hypoglycemic agents with pleiotropic vascular protective and anti-inflammatory effects. The therapeutic potential of a Glp-1 analogue in a diabetic rat model of excisional wound injury was investigated. MATERIALS AND METHODS: Excisional wounds were created on the dorsum of streptozotocin-induced diabetic rats, which received placebo or Glp-1 analogue exendin-4 (Ex4; 0...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993220/intestinal-alkaline-phosphatase-decreases-intraperitoneal-adhesion-formation
#11
Sanjiv K Hyoju, Sara Morrison, Sarah Gul, Mohammad Hadi Gharedaghi, Mohamed Mussa, Mehran Najibi, Konstantinos P Economopoulos, Sulaiman R Hamarneh, Richard A Hodin
BACKGROUND: Damage to the peritoneum initiates an inflammatory response leading to the formation of adhesions, which subsequently cause significant morbidity in some patients. Intestinal alkaline phosphatase (IAP) is a gut enzyme capable of detoxifying various inflammatory mediators such as lipopolysaccharide, lipoteichoic acid, CpG DNA, and adenosine triphosphate. In this study, we aimed to examine the anti-inflammatory effects of IAP on postoperative adhesions in mice. METHODS: C57BL/6 mice were subjected to a midline laparotomy and then six musculoperitoneal buttons (MPBs) were created by pinching and ligating the peritoneum and underlying muscle...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993219/behavior-of-a-new-long-chain-cyanoacrylate-tissue-adhesive-used-for-mesh-fixation-in-hernia-repair
#12
Juan M Bellón, Mar Fernández-Gutiérrez, Marta Rodríguez, Paloma Pérez-López, Bárbara Pérez-Köhler, Andree Kühnhardt, Gemma Pascual, Julio San Román
BACKGROUND: Synthetic tissue adhesives (TA) are sometimes used in hernia repair surgery. This study compares the use of a new, noncommercial, long-chain cyanoacrylate (n-octyl) TA and Ifabond for mesh fixation. MATERIALS AND METHODS: In two implant models in the rabbit, expanded polytetrafluorethylene meshes were fixed to the parietal peritoneum using a TA or tacks (intraperitoneal model), or polypropylene meshes used to repair partial abdominal wall defects were fixed with a TA or sutures (extraperitoneal model)...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993218/magnetic-compression-anastomosis-for-enteroenterostomy-under-peritonitis-conditions-in-dogs
#13
Hongke Zhang, Kai Tan, Chao Fan, Jingwei Du, Jiangbin Li, Tao Yang, Yi Lv, Xilin Du
BACKGROUND: The risk of complications and mortality are high after enteroenterostomy in severe peritonitic conditions. Magnetic compression anastomosis (MCA) is a sutureless technique of high efficacy and safety. The purpose of this study was to compare the efficacy of MCA for enteroenterostomy with stapled and hand-sewn techniques under peritonitic conditions. METHODS: The peritonitic conditions were created by puncturing the colon with a circular blade in 27 mongrel dogs...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993217/comparing-industry-compensation-of-cardiothoracic-surgeons-and-interventional-cardiologists
#14
Joshua Parreco, Elie Donath, Robert Kozol, Cristiano Faber
BACKGROUND: The purpose of this study was to compare payment trends between cardiothoracic surgeons and interventional cardiologists using the Open Payments website made available for the public by the Center for Medicare and Medicaid Services. MATERIAL AND METHODS: Data were extracted from the second release of the Open Payments database, which includes payments made between August 1, 2013 and December 31, 2014. Total payments to individual physicians were aggregated based on specialty, region of the country, and payment type...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993216/vascular-endothelial-growth-factor-expression-is-an-independent-poor-prognostic-factor-for-human-epidermal-growth-factor-receptor-2-positive-gastric-cancer
#15
Jun-Te Hsu, Tai-Di Chen, Huei-Chieh Chuang, Shih-Chiang Huang, Puo-Hsien Le, Tsung-Hsing Chen, Chun-Jung Lin, Ta-Sen Yeh
BACKGROUND: The positive expression of human epidermal growth factor receptor 2 (HER-2) is phenotypically associated with differentiated gastric cancer (GC) and is a prognostic factor for resectable GC. The aim of this study was to explore the clinical significance of vascular endothelial growth factor (VEGF), protein kinase B, and p38 mitogen-activated protein kinase (MAPK) regarding outcome in patients with HER-2 positive GC, and to analyze the relationship between these molecules and clinicopathologic parameters...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993215/anti-pd-l1-peptide-improves-survival-in-sepsis
#16
Yuichiro Shindo, Jacquelyn S McDonough, Katherine C Chang, Murali Ramachandra, Pottayil G Sasikumar, Richard S Hotchkiss
BACKGROUND: Sepsis remains a leading cause of death in most intensive care units. Many deaths in sepsis are due to nosocomial infections in patients who have entered the immunosuppressive phase of the disorder. One cause of immunosuppression in sepsis is T-cell exhaustion mediated by programmed cell death-1 (PD-1) interaction with its ligand (PD-L1). Studies demonstrated that blocking the interaction of PD-1 with PD-L1 with knockout mice or inhibitory antibodies reversed T-cell dysfunction and improved sepsis survival...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993214/predictors-of-residual-disease-after-unplanned-excision-of-soft-tissue-sarcomas
#17
Alicia A Gingrich, Alexandra Elias, Chia-Yuan Michael Lee, Yves-Paul N Nakache, Chin-Shang Li, Dhruvil R Shah, Robert D Boutin, Robert J Canter
BACKGROUND: Unplanned excision of soft tissue sarcomas (STS) is an important quality of care issue given the morbidity related to tumor bed excision. Since not all patients harbor residual disease at the time of reexcision, we sought to determine predictors of residual STS following unplanned excision. METHODS: We identified 76 patients from a prospective database (January 1, 2008-September 30, 2014) who received a diagnosis of primary STS following unplanned excision on the trunk or extremities...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993213/an-ex%C3%A2-vivo-comparison-of-adenosine-and-lidocaine-solution-and-university-of-wisconsin-solution-for-hypothermic-machine-perfusion-of-porcine-kidneys-potential-for-development
#18
Karim Hamaoui, Adeel Aftab, Sally Gowers, Martyn Boutelle, Terry Cook, Donna Rudd, Geoffrey P Dobson, Vassilios Papalois
BACKGROUND: The optimal hypothermic machine perfusion (HMP) solution has not yet been developed. An adenosine and lidocaine (AL) solution has been shown to be protective in cardiac preservation. The aim of the present study was to examine a modified AL solution with low Ca(2+), 16 mM Mg(2+), and 4% albumin on kidney preservation compared with University Wisconsin solution (UW). METHODS: Twenty donation of organs after cardiac death porcine kidneys underwent HMP for 10 h (AL, n = 10; UW, n = 10) and then 2 h of normothermic reperfusion...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993212/criteria-derived-from-serum-markers-can-precisely-evaluate-axillary-status-in-breast-cancer-patients
#19
Hangyu Wan, Zhenggui Du, Quanyi Long, Qing Lü, Hongjiang Li
BACKGROUND: A noninvasive method to confirm the presence of lymph node metastases (LNM) in breast cancer patients is lacking. This study aimed to identify markers from peripheral blood that have diagnostic value in evaluating axillary LNM. METHODS: We tested 26 factors in serum from 57 patients with resectable breast cancer by the Luminex assay. Differences between node-negative and node-positive patients were assessed. The diagnostic value of the factors was determined by further analyses and a validation test...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27993211/trauma-patients-who-present-in-a-delayed-fashion-a-unique-and-challenging-population
#20
Mary J Kao, Hector Nunez, Sean F Monaghan, Daithi S Heffernan, Charles A Adams, Stephanie N Lueckel, Andrew H Stephen
BACKGROUND: A proportion of trauma patients present for evaluation in a delayed fashion after injury, likely due to a variety of medical and nonmedical reasons. There has been little investigation into the characteristics and outcomes of trauma patients who present delayed. We hypothesize that trauma patients who present in a delayed fashion are a unique population at risk of increased trauma-related complications. MATERIALS AND METHODS: This was a retrospective review from 2010-2015 at a Level I trauma center...
February 2017: Journal of Surgical Research
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