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Journal of Surgical Research

Evan Patchen Dellinger, Andrew Bowdle, Srdjan Jelacic
No abstract text is available yet for this article.
October 12, 2018: Journal of Surgical Research
Barbara C Cahill, Sanjeev Raman, John R Stringham, Stephen H McKellar, Craig H Selzman, Theodore G Liou
No abstract text is available yet for this article.
September 4, 2018: Journal of Surgical Research
Stephen A Castellanos, Gerardo Buentello, Diana Gutierrez-Meza, Angela Forgues, Lisa Haubert, Avo Artinyan, Cameron L Macdonald, James W Suliburk
No abstract text is available yet for this article.
August 30, 2018: Journal of Surgical Research
Bijan S Kheirabadi, Irasema B Terrazas, Nahir Miranda, Amber N Voelker, Harold G Klemcke, Ammon W Brown, Michael A Dubick
BACKGROUND: Specialized tourniquets have been deployed to the battlefield for the control of junctional/pelvic hemorrhage despite limited knowledge concerning their safety and duration of use. This study investigated long-term effects of abdominal application of the abdominal aortic and junctional tourniquet (AAJT) in a swine survival model. METHODS: Anesthetized spontaneously air-breathing swine were subjected to bilateral femoral artery injuries and subsequent 40% hemorrhage...
November 2018: Journal of Surgical Research
Masoud Yavari, Hormoz Mahmoudvand, Sedigheh Nadri, Abdolreza Rouientan
BACKGROUND: There is a very small chance of success for nerve reconstruction in patients with old total brachial plexus palsy who visit after 2 y or suffer from flail upper extremity after the failure of previous operations. MATERIALS AND METHODS: For these individuals, the surgeon has to find a recipient motor nerve to perform free gracilis muscle transplantation. In this study, contralateral medial pectoral nerve from the intact side was transferred to the damaged side as a recipient nerve...
November 2018: Journal of Surgical Research
Zhicheng Jin, Shao Chen, Hongqiang Wu, Jieke Wang, Long Wang, Weiyang Gao
BACKGROUND: The survival ratio of multiterritory perforator flap is variable. Therefore, surviving mechanisms are increasingly explored to identify novel therapeutics. The condition of the choke zone is essential for perforator flap survival. In this study, we investigated autophagy in the choke zone after flap surgery. MATERIALS AND METHODS: The flap model involved a perforator flap with three territories that was located on the right dorsal side of a rat. A total of 36 rats were divided into six groups, including the control, 0 d postoperative (PO), 1, 3, 5, and 7 d PO groups...
November 2018: Journal of Surgical Research
Tariq Almerey, Emmanuel M Gabriel, Klaus D Torp, Sanjay P Bagaria
BACKGROUND: Multiple studies highlight the importance of liberal fluid administration in cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Over-resuscitation can delay recovery and wound healing. We report an intraoperative protocol that restricts fluid administration and minimizes morbidity. MATERIALS AND METHODS: Retrospective analysis of 35 patients that underwent CRS-HIPEC for curative intent under fluid restriction protocol from June 2015 to July 2017 was performed...
November 2018: Journal of Surgical Research
James E Tooley, Lindsay A Sceats, Daniel D Bohl, Blake Read, Cindy Kin
BACKGROUND: Abdominoperineal resection (APR) is primarily used for rectal cancer and is associated with a high rate of complications. Though the majority of APRs are performed as open procedures, laparoscopic APRs have become more popular. The differences in short-term complications between open and laparoscopic APR are poorly characterized. METHODS: We conducted a retrospective cohort study using the American College of Surgeons National Surgical Quality Improvement Program database to determine the frequency and timing of onset of 30-d postoperative complications after APR and identify differences between open and laparoscopic APR...
November 2018: Journal of Surgical Research
David Metcalfe, Manuel Castillo-Angeles, Olubode A Olufajo, Arturo J Rios-Diaz, Ali Salim, Adil H Haider, Joaquim M Havens
BACKGROUND: Racial and socioeconomic disparities are well documented in emergency general surgery (EGS) and have been highlighted as a national priority for surgical research. The aim of this study was to identify whether disparities in the EGS setting are more likely to be caused by major adverse events (MAEs) (e.g., venous thromboembolism) or failure to respond appropriately to such events. METHODS: A retrospective cohort study was undertaken using administrative data...
November 2018: Journal of Surgical Research
Peter J Lawson, Hunter B Moore, Ernest E Moore, Mark E Gerich, Gregory R Stettler, Anirban Banerjee, Richard D Schulick, Trevor L Nydam
BACKGROUND: Elevated clot strength (maximum amplitude [MA]) measured by thrombelastography (TEG) is associated with thrombotic complications. However, it remains unclear how MA translates to thrombotic risks, as this measurement is independent of time, blood flow, and clot degradation. We hypothesize that under flow conditions, increased clot strength correlates to time-dependent measurements of coagulation and resistance to fibrinolysis. MATERIALS AND METHODS: Surgical patients at high risk of thrombotic complications were analyzed with TEG and total thrombus-formation analysis system (T-TAS)...
November 2018: Journal of Surgical Research
Erica M Carlisle, Laura A Shinkunas, Lauris C Kaldjian
BACKGROUND: Shared decision-making (SDM) is touted as the preferred approach to clinical counseling. However, few data exist regarding whether patients prefer SDM over surgeon-guided discussions for complex surgical decision-making. Even fewer data exist regarding surgeon preferences. Such issues may be especially pronounced in pediatric surgery given the complex decision-making triad between patients/parents and surgeons. The objective of this systematic review was to evaluate patient/parent and surgeon attitudes toward SDM in pediatric surgery...
November 2018: Journal of Surgical Research
Damien W Carter, Ravi F Sood, Max E Seaton, Lara A Muffley, Shari Honari, Ann M Hocking, Saman A Arbabi, Nicole S Gibran
BACKGROUND: Systemic inflammatory response syndrome (SIRS) is associated with organ failure and infectious complications after major burn injury. Recent evidence has linked melanocortin signaling to anti-inflammatory and wound-repair functions, with mutations in the melanocortin 1 receptor (MC1R) gene leading to increased inflammatory responses. Our group has previously demonstrated that MC1R gene polymorphisms are associated with postburn hypertrophic scarring. Thus, we hypothesized that MC1R single nucleotide polymorphisms (SNPs) would be associated with increased burn-induced SIRS and increased infectious complications...
November 2018: Journal of Surgical Research
Astrid Botty Van Den Bruele, Bharti Jasra, Carmen Smotherman, Marie Crandall, Laila Samiian
BACKGROUND: Re-excision rates after breast conservation surgery are reported to be 20%-40%. Inaccuracies with specimen orientation may affect margin assessment. This study examined whether the addition of surgeon performed intraoperative inking of the lumpectomy specimen after adoption of margin guidelines would be cost-effective. METHODS: A retrospective review of a prospective surgical database was performed from 2009 to 2017. Patients with initial lumpectomy and a preoperative diagnosis of invasive breast carcinoma or ductal carcinoma in situ (DCIS) were included...
November 2018: Journal of Surgical Research
Galinos Barmparas, Navpreet K Dhillon, James M Tatum, Kavita Patel, Gretchen M Thomsen, Russell Mason, Daniel R Margulies, Eric J Ley
BACKGROUND: Neuromuscular blockade (NMB) is often utilized in the treatment of acute respiratory distress syndrome (ARDS). Its use for a period of 48 h has been shown to improve mortality in randomized control trials. We aimed to characterize outcomes associated with a prolonged NMB. We hypothesized that the duration of NMB would not be associated with increased mortality. MATERIALS AND METHODS: This was a retrospective review from June 2014 to October 2016 of patients admitted to the surgical intensive care unit and receiving cisatracurium for ARDS...
November 2018: Journal of Surgical Research
Alex J Bartholomew, Hayden Dohnalek, Petra A Prins, Suzanne C O'Neill, Humair S Quadri, John L Marshall, Nadim G Haddad, Waddah B Al-Refaie
BACKGROUND: Tyrosine kinase inhibitors (TKI) have become the guideline-recommended therapy for high-risk resected and advanced gastrointestinal stromal tumors (GISTs). Exon mutational analysis (EMA) is used to inform pretherapy response to TKI and may predict overall prognosis. Despite these benefits, EMA remains underused, and its impact on TKI therapy decision-making remains unexplored. MATERIALS AND METHODS: A retrospective cohort was established from 104 patients receiving treatment for GISTs from 2006 to 2017...
November 2018: Journal of Surgical Research
Nathalie C Dragnev, Sandra L Wong
BACKGROUND: Clinical case reports are important sources of information on the identification and treatment of new or rare diseases. The CAse REport (CARE) Statement and Checklist represents consensus-based guidelines for clinical case reports. How well case reports adhere to these guidelines is unknown. MATERIAL AND METHODS: A systematic PubMed and OVID search was used to identify case reports on isolated splenic metastasis from 2007 to 2017 in English language journals...
November 2018: Journal of Surgical Research
Katherine L Bailey, Peter Downey, Yas Sanaiha, Esteban Aguayo, Young-Ji Seo, Richard J Shemin, Peyman Benharash
BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) has emerged as a common therapy for severe cardiopulmonary dysfunction. We aimed to describe the relationship of institutional volume with patient outcomes and examine transfer status to tertiary ECMO centers. MATERIALS AND METHODS: Using the National Inpatient Sample, we identified adult patients who received ECMO from 2008 to 2014. Individual hospital volume was calculated as tertiles of total institutional discharges for each year independently...
November 2018: Journal of Surgical Research
Zachary D Fox, Guihua Jiang, Kenneth K Y Ho, Kendal A Walker, Allen P Liu, Shaun M Kunisaki
BACKGROUND: The purpose of this study was to employ a novel ex vivo lung model of congenital diaphragmatic hernia (CDH) to determine how a mechanical compression affects early pulmonary development. METHODS: Day-15 whole fetal rat lungs (n = 6-12/group) from nitrofen-exposed and normal (vehicle only) dams were explanted and cultured ex vivo in compression microdevices (0.2 or 0.4 kPa) for 16 h to mimic physiologic compression forces that occur in CDH in vivo...
November 2018: Journal of Surgical Research
Meng-Yun Ke, Mei Zhang, Qing Su, Shasha Wei, Jia Zhang, Yue Wang, Rongqian Wu, Yi Lv
BACKGROUND: There is a strong correlation between liver fibrosis and postoperative morbidity after hepatectomy in hepatocellular carcinoma (HCC) patients. The aim of this study was to evaluate which noninvasive fibrosis index (gamma-glutamyl transpeptidase to platelet ratio [GPR], aspartate aminotransferase to platelet ratio index, fibrosis-4 index, or Forns index) was best able to predict complications in patients undergoing hepatectomy for HCC. MATERIALS AND METHODS: This retrospective analysis included 275 patients who underwent hepatectomy for HCC from January 2008 to December 2012...
November 2018: Journal of Surgical Research
Kyle Freischlag, Paul M Schroder, Brian Ezekian, Morgan L Cox, Michael S Mulvihill, Matthew G Hartwig, Stuart J Knechtle
BACKGROUND: Liver-lung transplantation (LLT) is a rare procedure performed for patients with end-stage liver and lung disease. The lung allocation score (LAS), introduced in 2005, guides lung allocation including those receiving LLT. However, the impact of the LAS on outcomes in LLT is currently unknown. MATERIALS AND METHODS: The OPTN/United Network for Organ Sharing STAR file was queried for LLT candidates and recipients from 1988 to 2016. Demographic characteristics before (historic) and after (modern) the LAS were compared...
November 2018: Journal of Surgical Research
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