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Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/28437582/modified-frailty-index-predicts-postoperative-outcomes-in-older-gastrointestinal-cancer-patients
#1
Sarah A Vermillion, Fang-Chi Hsu, Robert D Dorrell, Perry Shen, Clancy J Clark
BACKGROUND AND OBJECTIVES: Frailty disproportionately impacts older patients with gastrointestinal cancer, rendering them at increased risk for poor outcomes. A frailty index may aid in preoperative risk stratification. We hypothesized that high modified frailty index (mFI) scores are associated with adverse outcomes after tumor resection in older, gastrointestinal cancer patients. METHODS: Patients (60-90 years old) who underwent gastrointestinal tumor resection were identified in the 2005-2012 NSQIP Participant Use File...
April 24, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420040/semi-end-to-end-esophagojejunostomy-after-laparoscopy-assisted-total-gastrectomy-better-reduces-stricture-and-leakage-than-the-conventional-end-to-side-procedure-a-retrospective-study
#2
Wei Duan, Kaijun Liu, Xiaolong Fu, Xuqi Shen, Jun Chen, Chongyu Su, Peiwu Yu, Yongliang Zhao
BACKGROUND AND OBJECTIVE: Laparoscopy-assisted total gastrectomy (LATG) has not gained popularity due to the technical difficulty of esophagojejunostomy (EJ) and the high incidence of EJ-related complications. Herein, we compared two types of EJ for Roux-en-Y reconstruction to determine whether semi-end-to-end (SETE) EJ is more convenient than the end-to-side (ETS) procedure and is capable of reducing stricture and leakage. METHODS: A total of 268 patients who underwent LATG with Roux-en-Y reconstruction were included in this study...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420039/utilizing-salmonella-to-treat-solid-malignancies
#3
REVIEW
Nancy D Ebelt, Edwin R Manuel
Despite intensive research into novel treatment strategies for cancer, it remains the second most common cause of death in industrialized populations. Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with dismal prognosis. Currently, surgical resection offers the best chance for extended survival, yet recurrence remains high and is associated with poor outcome. Systemic treatment has evolved from non-specific, cytotoxic chemotherapy to the use of cancer-targeting agents, profoundly changing treatment approaches in the metastatic and adjuvant settings...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420037/does-surgery-or-radiation-provide-the-best-overall-survival-in-ewing-s-sarcoma-a-review-of-the-national-cancer-data-base
#4
Benjamin J Miller, Yubo Gao, Kyle R Duchman
BACKGROUND AND OBJECTIVES: There is continuing debate regarding the ideal modality for local control of the primary tumor for patients with Ewing's sarcoma. The primary aim of this study is to investigate the impact of the method of local control on overall survival in patients with Ewing's sarcoma. METHODS: The National Cancer Data Base was used to identify patients <40 years of age with high-grade Ewing's sarcoma of bone. A Kaplan-Meier survival analysis was performed at 2, 5, and 10 years...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420036/dedifferentiated-chondrosarcoma-a-survival-analysis-of-159-cases-from-the-seer-database-2001-2011
#5
Patrick K Strotman, Taylor J Reif, Stephanie A Kliethermes, Jasmin K Sandhu, Lukas M Nystrom
BACKGROUND AND OBJECTIVES: Dedifferentiated chondrosarcoma is a rare malignancy with reported 5-year overall survival rates ranging from 7% to 24%. The purpose of this investigation is to determine the overall survival of dedifferentiated chondrosarcoma in a modern patient series and how it is impacted by patient demographics, tumor characteristics, and surgical treatment factors. METHODS: This is a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database from 2001 to 2011...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420035/prospective-series-of-reconstruction-of-complex-composite-mandibulectomy-defects-with-double-island-free-fibula-flap
#6
Edward I Chang, Peirong Yu
BACKGROUND: A double island free fibula (DIFF) flap can be used for reconstruction of through-and-through or complex mandibulectomy defects, but prospective studies are lacking. METHODS: Prospective analysis of all double skin paddle fibula flaps performed from 2010 to 2016. RESULTS: Overall, 16 patients underwent reconstruction with a DIFF flap (average age: 59.1 years). One patient, who underwent a DIFF flap and developed osteoradionecrosis, requiring a second flap...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28420032/identifying-a-subset-of-patients-with-dcis-who-have-a-low-likelihood-of-residual-disease-at-surgical-excision-following-a-core-needle-biopsy
#7
Brittany L Murphy, Alexandra B Gonzalez, Amy L Conners, Tara L Henrichsen, Michael G Keeney, Beiyun Chen, Toan T Nguyen, William S Harmsen, Elizabeth B Habermann, Harsh N Shah, James W Jakub
BACKGROUND AND OBJECTIVES: Current randomized controlled trials are investigating the outcomes of non-surgical treatment for patients with ductal carcinoma in situ (DCIS). We sought to evaluate pre-operative factors associated with no residual disease at definitive resection following a core needle biopsy (CNB) diagnosis of DCIS. METHODS: Eight hundred and thirty-four operations for DCIS were performed at our institution between January 2004 and October 2014. We evaluated patient and biopsy tumor characteristics to determine pre-operative factors associated with no residual disease at surgical resection using uni- and multivariable analyses...
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28418583/lung-cancer-a-global-perspective
#8
REVIEW
Amanda McIntyre, Apar Kishor Ganti
Lung cancer is the leading cause of cancer deaths worldwide. While tobacco exposure is responsible for the majority of lung cancers, the incidence of lung cancer in never smokers, especially Asian women, is increasing. There is a global variation in lung cancer biology with EGFR mutations being more common in Asian patients, while Kras mutation is more common in Caucasians. This review will focus on the global variations in lung cancer and its treatment.
April 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28411392/clinical-prognostic-markers-in-stage-iiic-melanoma
#9
Max F Madu, Jaap H H Schopman, Danique M S Berger, Willem M C Klop, Katarzyna Jóźwiak, Michel W J M Wouters, Jos A van der Hage, Alexander C J van Akkooi
BACKGROUND: Although the EORTC 18071-trial has shown a clear survival benefit for adjuvant ipilimumab, accurately selecting patients for this toxic adjuvant therapy is important. We aimed to identify prognostic factors for death and disease recurrence in AJCC stage IIIC melanoma patients. PATIENTS AND METHODS: Retrospective analysis of patients who underwent lymph node dissection (LND) for stage IIIC melanoma in our institution between 2000 and 2016. Baseline characteristics, melanoma-specific survival (MSS), and disease-free survival (DFS) were assessed, and prognostic factors for recurrence and survival were analyzed using uni- and multivariable analysis...
April 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28411373/impact-of-major-vascular-resection-on-outcomes-and-survival-in-patients-with-intrahepatic-cholangiocarcinoma-a-multi-institutional-analysis
#10
Bradley N Reames, Aslam Ejaz, Bas Groot Koerkamp, Sorin Alexandrescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Guillaume Martel, James Wallis Marsh, Timothy M Pawlik
BACKGROUND: Major vascular involvement (IVC or portal vein) for intrahepatic cholangiocarcinoma (ICC) has traditionally been considered a contraindication to resection. We sought to define perioperative outcomes and survival of ICC patients undergoing hepatectomy with major vascular resection in a large international multi-institutional database. METHODS: A total of 1087 ICC patients who underwent curative-intent hepatectomy between 1990 and 2016 were identified from 13 institutions...
April 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28411368/laparoscopy-specific-ventral-approach-in-laparoscopic-hemihepatectomy
#11
Ji Hoon Kim
BACKGROUND: The laparoscopic caudal approach is very different from the open ventral approach, specifically with respect to the surgical view, which is completely different and is the underlying reason for why laparoscopic hepatectomy is technically challenging. We have introduced a new laparoscopy-specific ventral approach in laparoscopic hemihepatectomy. METHODS: The liver was transected from the ventral side to the dorsal side, via a flexible laparoscope, as in open liver resection...
April 14, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28409847/trends-in-immediate-breast-reconstruction-and-early-complication-rates-among-older-women-a-big-data-analysis
#12
Parisa Kamali, Daniel Curiel, Charlotte L van Veldhuisen, Alexandra E M Bucknor, Bernard T Lee, Hinne A Rakhorst, Samuel J Lin
BACKGROUND: Although approximately 57% of breast cancer (BC) diagnoses are in older patients (>60 years), only 4.1-14% receives breast reconstruction (BR). This has been attributed to physician concerns about operative complications. This paper aims to: 1) analyze the 30-day complication rates in the older patient population undergoing immediate breast reconstruction (IBR); and 2) analyze links between complication type and category of reconstruction. METHODS: Using the ACS-NSQIP database (2005-2014), all women older than 60 years of age diagnosed with BC and DCIS were identified...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28409837/clinical-accuracy-of-preoperative-breast-mri-for-breast-cancer
#13
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao
BACKGROUND: It is unclear if breast magnetic resonance imaging (MRI) is more accurate than mammography (MGM) and ultrasound (U/S) in aggregate for patients with invasive cancer. METHODS: We compared concordance of combined tumor size and tumor foci between MRI and MGM and U/S combined to pathological tumor size and foci as the gold standard from 2009 to 2015. Tumor size was nonconcordant if it differed from the pathologic size by ≥33% and tumor foci was nonconcordant if >1 foci were seen...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28409832/influence-of-neoadjuvant-chemotherapy-on-resection-of-primary-colorectal-liver-metastases-a-propensity-score-analysis
#14
Moritz J Strowitzki, Thomas Schmidt, Ulrich Keppler, Alina S Ritter, Sarah Mahmoud, Johannes Klose, André L Mihaljevic, Martin Schneider, Markus W Büchler, Alexis B Ulrich
BACKGROUND AND OBJECTIVES: There is ongoing debate about whether patients planned for liver resection of colorectal liver metastases (CRLM) benefit from neoadjuvant chemotherapy (NC). Therefore, we performed a retrospective survival analysis of patients with and without NC prior to surgery. METHODS: Data prospectively collected from 468 consecutive patients were analyzed in a retrospective design. We performed a survival analysis and added propensity score matching (PSM)...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28409831/postoperative-complications-affect-long-term-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-peritoneal-carcinomatosis
#15
Lawrence Lee, Fanny Alie-Cusson, Pierre Dubé, Lucas Sideris
BACKGROUND AND OBJECTIVES: Morbidity after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) for colorectal peritoneal carcinomatosis (PC) may negatively affect survival. The objective was to determine the impact of postoperative complications (CX) on survival in patients undergoing CRS + HIPEC for colorectal PC. METHODS: All patients undergoing laparotomy for planned CRS + HIPEC for colorectal PC at a single institution from 1999 to 2014 were included...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407327/oncolytic-viral-therapy-for-pancreatic-cancer
#16
REVIEW
Ahmad Rahal, Benjamin Musher
Outcomes of pancreatic adenocarcinoma (PDA) remain dismal despite extensive clinical investigation. Combination chemotherapy provides modest improvements in survival above best supportive care, and immunotherapy has thus far not proven effective. Nevertheless, growing insight into antitumor immunity and the tumor microenvironment has inspired the discovery of novel agents targeting PDA. Oncolytic viruses represent an emerging class of immunotherapeutic agents that have undergone extensive preclinical investigation and warrant further investigation in well-designed clinical trials...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407317/reconstruction-of-quadriceps-function-with-composite-free-tissue-transfers-following-sarcoma-resection
#17
Kempland C Walley, Erin M Taylor, Megan Anderson, Santiago Lozano-Calderon, Matthew L Iorio
BACKGROUND AND OBJECTIVES Wide margin resection of a soft tissue sarcoma (STS) may require extensive removal of quadriceps muscle with or without the knee extensor mechanism. The objective of this study is to present present the use of a combined functional muscle transfer and soft tissue coverage through the use of chimeric anterolateral thigh flaps. METHODS: Patients were retrospectively reviewed who underwent deep STS resection of the anterior compartment of the thigh with functional reconstruction of knee extension using a contralateral free anterolateral thigh (ALT) flap...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407313/prognosis-of-primary-tracheal-tumor-a-population-based-analysis
#18
Jiaxi He, Jianfei Shen, Jun Huang, Chenyang Dai, Wenhua Liang, Minhua Ye, Min Kong, Baofu Chen, Chengchu Zhu, Jianxing He
BACKGROUND: To elucidate the survival outcomes of tracheal tumors and to propose the potential stage of tracheal tumors. METHOD: All cases of primary tracheal malignant tumors were extracted from the Surveillance, Epidemiology, and End Results database (SEER) during 1973-2013. The overall survival was calculated using Kaplan-Meier method. Cox regression was utilized to identify the prognostic factors. RESULT: A total of 287 cases were finally included...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407261/nationwide-trends-and-outcomes-associated-with-neoadjuvant-therapy-in-pancreatic-cancer-an-analysis-of-18%C3%A2-243-patients
#19
Linda M Youngwirth, Daniel P Nussbaum, Samantha Thomas, Mohamed A Adam, Dan G Blazer, Sanziana A Roman, Julie A Sosa
BACKGROUND: Neoadjuvant therapy has theoretical benefits for pancreatic cancer; however, its association with perioperative outcomes remains controversial. This study sought to evaluate variation in use of neoadjuvant therapy and outcomes following pancreatic resection. METHODS: The National Cancer Data Base (1998-2011) was queried for patients with Stage I or II pancreatic adenocarcinoma who underwent pancreaticoduodenectomy. Subjects were classified by use of neoadjuvant chemotherapy and/or radiation therapy...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28407247/using-the-21-gene-assay-from-core-needle-biopsies-to-choose-neoadjuvant-therapy-for-breast-cancer-a-multicenter-trial
#20
Harry D Bear, Wen Wan, André Robidoux, Peter Rubin, Steven Limentani, Richard L White, James Granfortuna, Judith O Hopkins, Dwight Oldham, Angel Rodriguez, Amy P Sing
OBJECTIVE: We hypothesized that the Oncotype Dx(®) 21-gene Recurrence Score (RS) could guide neoadjuvant systemic therapy (NST) to facilitate breast conserving surgery (BCS) for hormone receptor positive (HR+) breast cancers. METHODS: This study enrolled patients with HR+, HER2-negative, invasive breast cancers not suitable for BCS (size ≥ 2 cm). Core needle biopsy blocks were tested. For tumors with RS < 11, patients received hormonal therapy (NHT); patients with RS > 25 tumors received chemotherapy (NCT); patients with RS 11-25 were randomized to NHT or NCT...
April 13, 2017: Journal of Surgical Oncology
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