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Journal of Surgical Oncology

Tavis Read, Warren Fayers, Janine Thomas, Michael Wagels, Andrew Barbour, B Mark Smithers
BACKGROUND AND OBJECTIVE: Isolated limb infusion (ILI) and intralesional PV-10 are well described locoregional therapies for in-transit melanoma. The objective of this study was to assess the effect of these treatments on survival outcomes within a cohort matched for key characteristics. METHODS: Patients were treated using ILI or intralesional PV-10 at a single institution and the data prospectively recorded. Propensity score matching was performed using key covariates within a logistic regression model...
January 15, 2019: Journal of Surgical Oncology
Kelly M Bridgham, Jad M El Abiad, Zhen A Lu, Deepa Bhat, Halley Darrach, Carol D Morris, Adam S Levin, Justin M Sacks
BACKGROUND: Reconstructive surgery is often required following lower extremity soft tissue sarcoma resection. The relationship between the method of plastic surgery reconstruction and postoperative wound healing or functional oncologic outcomes in this patient population is poorly understood. METHODS: We performed a retrospective review on all adult patients that underwent soft tissue reconstruction following resection of lower extremity soft tissue sarcomas between 1996 and 2016 at our institution...
January 15, 2019: Journal of Surgical Oncology
Lieve G J Leijssen, Anne M Dinaux, Ramzi Amri, Martin S Taylor, Vikram Deshpande, Liliana G Bordeianou, Hiroko Kunitake, David L Berger
BACKGROUND AND OBJECTIVES: Vascular invasion, in particular extramural venous invasion (EMVI), is a pathologic characteristic that has been extensively studied in rectal cancer but rarely in colon cancer. This study aims to evaluate its prognostic role in stage II-III colon cancer. METHODS: All stage II-III colon cancer patients who underwent surgery between 2004 and 2015 were reviewed. We compared patients without invasion, with intramural invasion only (IMVI), EMVI only, and both IMVI/EMVI (n = 923)...
January 15, 2019: Journal of Surgical Oncology
Sanne Høxbroe Michaelsen, Marie Juul Ornstrup, Morten Møller Poulsen, Finn Noe Bennedbaek, Mette Gaustadnes, Maria Rossing, Peter Darling, Peter Vestergaard, Jes Sloth Mathiesen
BACKGROUND AND OBJECTIVES: Recently, a comprehensive study presented evidence that a long-disputed REarranged during Transfection (RET) variant, RET Y791F, should be classified as nonpathogenic. In spite of this, several subsequently published papers, including the revised American Thyroid Association guidelines for medullary thyroid carcinoma, refer to the variant as pathogenic. This study presents data from a unique national Danish cohort of RET Y791F carriers who have been followed by watchful waiting instead of being subjected to early thyroidectomy, to determine if any carrier shows evidence of multiple endocrine neoplasia 2A (MEN2A) at long-term follow-up...
January 15, 2019: Journal of Surgical Oncology
Maria R Baimas-George, David M Levi, Lon B Eskind, Russell C Kirks, Michael Passeri, Mark Lessne, Dimitrios Kardassis, Stuart Salmon, David A Iannitti, Dionisios Vrochides
Incorporation of liver transplant techniques in hepatopancreaticobiliary surgery has created an opportunity for the resection of locally advanced hepatic tumors formerly considered unresectable. A 73-year-old woman presented with cholangiocarcinoma involving inferior vena cava, all three hepatic veins, and right anterior portal pedicle, initially deemed nonoperative. This case demonstrates the first combined application of associating liver partition and portal vein ligation for staged hepatectomy and ex vivo resection to perform an R0...
January 15, 2019: Journal of Surgical Oncology
Brandon C Chapman, Karyn Goodman, Patrick Hosokawa, Ana Gleisner, Michelle L Cowan, Elisa Birnbaum, Jon D Vogel
BACKGROUND: Randomized controlled trials have demonstrated comparable survival outcomes for short-course (SCRT) and long-course neoadjuvant radiotherapy (LCRT) in patients with rectal cancer. METHODS: Using the National Cancer Data Base (2004-2015), a propensity score was used to match 188 patients with rectal cancer receiving SCRT to 376 patients receiving LCRT. Perioperative, oncologic, and survival outcomes were compared. RESULTS: Patient and clinical tumor characteristics were similar between groups...
January 13, 2019: Journal of Surgical Oncology
Bobby V M Dasari, James Hodson, Robert P Sutcliffe, Ravi Marudanayagam, Keith J Roberts, Manuel Abradelo, Paolo Muiesan, Darius F Mirza, John Isaac
BACKGROUND: Hepatobiliary surgeons continue to expand the pool of patients undergoing liver resection using combinations of surgical and interventional procedures with chemotherapy. Improved perioperative care allows for operation on higher risk surgical patients. Postoperative outcomes, including 90-day mortality that improved over the past decade but still varies across cohorts. This study developed a preoperative risk score, on the basis significant clinical and laboratory variables, to predict 90-day mortality after hepatectomy...
January 13, 2019: Journal of Surgical Oncology
Francesco Sclafani, Gina Hesselberg, Stephen R Thompson, Philip Truskett, Koroush Haghighi, Sheela Rao, David Goldstein
BACKGROUND AND OBJECTIVES: There is limited evidence to guide the management of patients with oligometastatic anal squamous cell carcinoma (SCC). We aimed to address this question by reporting the outcome of SCC patients who were treated with organ-directed therapies at two large cancer centers. METHODS: Patients with advanced anal SCC who were treated with surgery, stereotactic radiotherapy, or radiofrequency ablation (RFA) with a curative intent from 2008 to 2017 were retrospectively identified from the institutional electronic patient records...
January 12, 2019: Journal of Surgical Oncology
Alexandra M Roch, Justine Schneider, Rosalie A Carr, William P Lancaster, Michael G House, Nicholas J Zyromski, Attila Nakeeb, C Max Schmidt, Eugene P Ceppa
BACKGROUND: Breast cancer (BRCA) mutations account for the highest proportion of hereditary causes of pancreatic ductal adenocarcinoma (PDAC). Screening is currently recommended only for patients with one first-degree relative or two family members with PDAC. We hypothesized that screening all BRCA1/2 patients would identify a higher rate of pancreatic abnormalities. METHODS: All BRCA1/2 patients at a single academic center were retrospectively reviewed (2005-2015)...
January 12, 2019: Journal of Surgical Oncology
Kosuke Ishikawa, Emi Funayama, Taku Maeda, Toshihiko Hayashi, Naoki Murao, Masayuki Osawa, Riri Ito, Hiroshi Furukawa, Akihiko Oyama, Yuhei Yamamoto
BACKGROUND AND OBJECTIVES: Vascularized lymph node transfer (LNT) is gaining popularity in the treatment of lymphedema. However, it is unclear whether the vascularization of transferred lymph nodes (LNs) contributes to functional improvement. High endothelial venules (HEVs) are specialized vessels that allow lymphocytes to enter LNs. In this study, we compared the numbers of HEVs and lymphocytes in LNs after vascularized and nonvascularized LNT. METHODS: Fifty mice were divided into three groups (group 1, pedicled vascularized LNT; group 2, pedicled nonvascularized LNT; group 3, free nonvascularized LNT)...
January 12, 2019: Journal of Surgical Oncology
Feng Yang, Chen Jin, Andrew L Warshaw, Li You, Yishen Mao, Deliang Fu
BACKGROUND: Total pancreatectomy may be necessary to achieve margin-negative resection for pancreatic cancer. However, despite the desirability of saving the spleen, the feasibility, safety, and oncological outcomes of spleen-preserving total pancreatectomy have not been studied in patients with malignancy involving the pancreatic neck or proximal body. The aim of this study was to report the efficacy of spleen-preserving total pancreatectomy using the Warshaw technique for patients with pancreatic malignancies...
January 12, 2019: Journal of Surgical Oncology
Meifeng He, Weizhen Yang, Jin Li, Zhanwu Jiang
No abstract text is available yet for this article.
January 10, 2019: Journal of Surgical Oncology
Justin Drake, Karen Chelcun Schreiber, Rachael Lopez, Grace-Ann Fasaye, Maureen Connolly, Martha Quezado, Theo Heller, Jonathan M Hernandez, Jeremy L Davis
No abstract text is available yet for this article.
January 7, 2019: Journal of Surgical Oncology
Pedro Ciudad, Mouchammed Agko, Tony C T Huang, Oscar J Manrique, Wei-Ling Chang, Fabio Nicoli, Michelle Maruccia, Federico Lo Torto, Hung-Chi Chen
BACKGROUND: End-stage lower extremity lymphedema (LEL) poses a particularly formidable challenge to surgeons as multiple pathological processes are at work. Because single modality treatment is often unsuccessful, we devised a comprehensive multimodal surgical treatment. The aim of this study is to share the technical considerations and examine the clinical outcomes of this combined approach. METHODS: Between 2013 and 2017, patients with International Society of Lymphology stage III, who underwent the combination treatment of Charles,' Homan's procedure with toe management and vascularized lymph node transfer (CHAHOVA), were included in this retrospective study...
January 6, 2019: Journal of Surgical Oncology
Jean-Camille Mattei, Véronique Brouste, Philippe Terrier, Sylvie Bonvalot, Axel Lecesne, Eberhard Stoeckle, Antoine Italiano, Dominique Ranchere-Vince, Pierre Meeus, Marick Lae, Philippe Rosset, Alexandre Rochwerger, Jean Michel Coindre, Sébastien Salas
BACKGROUND AND OBJECTIVES: Soft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS). METHODS: From 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Demographics, tumor type, treatment modalities, and latest follow-up status were collected...
January 4, 2019: Journal of Surgical Oncology
Pedro Ciudad, Oscar J Manrique, Kian Adabi, Tony Chieh-Ting Huang, Mouchammed Agko, Emilio Trignano, Wei-Ling Chang, Tsung-Wei Chen, Christopher J Salgado, Hung-Chi Chen
BACKGROUND: Treatment of advanced lymphedema requires not only restoration of physiological lymph drainage, but also excision of fibrotic tissue and excess skin. The aim of this study is to show how the combination of double vascularized lymph node transfers (VLNTs) and a modified radical reduction with preservation of perforators (RRPP) can accomplish both of these treatment goals. METHODS: Between 2010 and 2016, 16 patients (15 female and one male) with extremity lymphedema underwent a combined double gastroepiploic VLNTs and modified RRPP...
January 4, 2019: Journal of Surgical Oncology
Jing Yu, Ning Li, Yu Tang, Xin Wang, Yuan Tang, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Ye-Xiong Li, Jing Jin
BACKGROUND AND OBJECTIVES: To assess the efficacy and the effect of biologic effective dose (BED) on outcomes treated by hypofractionated stereotactic radiotherapy for colorectal cancer (CRC) oligometastases. METHODS: Patients with CRC oligometastases treated at our hospital between 2009 and 2016 were included. The relationship between BED and risk of local recurrence was assessed. Recursive partitioning analysis (RPA) was used to evaluate the effect of BED on outcomes...
January 4, 2019: Journal of Surgical Oncology
Hui Sun, Gianlorenzo Dionigi
No abstract text is available yet for this article.
January 4, 2019: Journal of Surgical Oncology
Alexandra Banks, Gerald Coronado, Robert Zimmerman, Geeta Iyengar, Dennis R Holmes
BACKGROUND: A prospective randomized controlled trial has established the efficacy of targeted intraoperative radiotherapy (TARGIT) in the management of invasive breast cancer treated with breast-conserving surgery (BCS). The purpose of this analysis is to evaluate the efficacy of TARGIT in the management of ductal carcinoma in situ (DCIS). METHODS: A prospective nonrandomized trial was designed to evaluate the success of TARGIT in the management of DCIS, as measured by a low risk of requiring additional surgery or radiotherapy and an acceptable local recurrence rate (LRR)...
December 27, 2018: Journal of Surgical Oncology
Jessica Y Liu, Michael Lowe
Neoadjuvant therapy has demonstrated promise as a treatment modality in resectable advanced-stage melanoma. Treatment has evolved beyond chemotherapy, with the utilization of biochemotherapy, immunotherapy, and targeted therapy in the neoadjuvant setting. These therapies have shown better progression-free survival and melanoma-specific survival when compared with patients that proceed directly to surgery. Ongoing clinical trials will continue to propel research forward to improve the available options for patients with resectable advanced regional disease...
December 27, 2018: Journal of Surgical Oncology
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