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Journal of Surgical Oncology

Michael W Manning, William Jonathan Dunkman, Timothy E Miller
Goal-directed fluid therapy (GDFT) seeks to improve outcomes through individualized optimization of oxygen delivery using IV fluid and vasoactive infusions. Trials of GDFT show clinical benefits over traditional liberal fluid administration, but fail to demonstrate benefits when compared to a restrictive strategy within an optimized enhanced recovery protocol. The ideal monitors, hemodynamic goals, and fluid administration strategy are not well established but may be less important than rational application of thoughtful fluid management strategies...
September 22, 2017: Journal of Surgical Oncology
Daniel Zainfeld, Hooman Djaladat
Coordinated multidisciplinary perioperative care through enhanced recovery protocols has improved outcomes within urologic surgery. Continued development and refinement of enhanced recovery after surgery (ERAS) pathways will further augment the care of patients undergoing all urologic procedures. Among the challenges, moving forward is identification of barriers to ERAS adoption by providers, maximizing adherence among patients, standardization of ERAS pathways through establishment of evidence-based principles, and application in additional complex urologic procedures beyond radical cystectomy...
September 22, 2017: Journal of Surgical Oncology
Shraddha Patkar, Vikas Ostwal, Anant Ramaswamy, Reena Engineer, Supriya Chopra, Nitin Shetty, Rohit Dusane, Shailesh V Shrikhande, Mahesh Goel
BACKGROUND AND OBJECTIVES: Gall bladder cancer (GBC) is a disease with high incidence in India. We analyzed the outcomes of patients with suspected GBC who underwent surgical exploration. METHODS: Analysis of a prospectively maintained database of patients undergoing surgical exploration for clinic-radiologically suspected GBC from January 2010 to August 2015. Outcomes as well as factors influencing survival were analyzed. RESULTS: Five hundred and ten patients underwent surgery for suspected GBC...
September 20, 2017: Journal of Surgical Oncology
Matthijs Plas, Patrick H J Hemmer, Lukas B Been, Robert J van Ginkel, Geertruida H de Bock, Barbara L van Leeuwen
BACKGROUND: Incidence of, and baseline characteristics associated with delirium in patients after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), were subject of investigation. METHODS: The study was conducted among a consecutive series of prospectively included patients who underwent CRS-HIPEC at the University Medical Center Groningen, Groningen, the Netherlands, between February 2006 and January 2015. A chart-based instrument for delirium during hospitalization was used to identify patients with symptoms of delirium who were not diagnosed by a psychiatrist during admission...
September 20, 2017: Journal of Surgical Oncology
Nicholas Manguso, Alexandra Gangi, Jeffrey Johnson, Attiya Harit, Nicholas Nissen, Laith Jamil, Simon Lo, Ashley Wachsman, Andrew Hendifar, Farin Amersi
BACKGROUND AND OBJECTIVES: Pre-operative localization of small bowel neuroendocrine tumors (SBNET) is important for operative planning. The aim was to determine the effectiveness of pre-operative imaging and double-balloon enteroscopy (DBE) in identifying extent of disease. METHODS: Database review identified 85 patients with primary SBNET between 2006 and 2013. Analysis included patients who underwent imaging, endoscopy, and surgery at our institution. RESULTS: Average age was 60...
September 20, 2017: Journal of Surgical Oncology
Byoung Hyuck Kim, Eunji Kim, Kyubo Kim, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Eui Kyu Chie
BACKGROUNDS: Perioperative CA19-9 value in pancreato-biliary cancers has been recognized as a prognostic factor. Herein, we investigated survival differences and recurrence patterns after adjuvant chemoradiotherapy by perioperative CA19-9 change in surgically resected extrahepatic cholangiocarcinoma. METHODS: Patients were divided into those with preoperative normal CA19-9 (Group 1, n = 52), those with high preoperative and normalized postoperative CA19-9 (Group 2, n = 80), and those with both high pre- and postoperative CA19-9 (Group 3, n = 21)...
September 20, 2017: Journal of Surgical Oncology
Kamran Idrees, Chandrasekhar Padmanabhan, Eric Liu, Yan Guo, Raul S Gonzalez, Jordan Berlin, Kimberly B Dahlman, R Daniel Beauchamp, Chanjuan Shi
BACKGROUND AND OBJECTIVES: The World Health Organization (WHO) 2010 has classified GI neuroendocrine neoplasms into neuroendocrine tumor (NET) and high-grade neuroendocrine carcinoma (NEC). The genetic underpinnings of NEC are poorly understood. The aim of the study was to perform genomic profiling of NEC to better characterize this aggressive disease. METHODS: We identified nine patients with colonic NEC between January 1, 2005 and June 30, 2013. Whole exome sequencing (WES) was performed on tumor DNA from two patients with ≥80% tumor cellularity and matched normal tissue available...
September 20, 2017: Journal of Surgical Oncology
Xu-Feng Zhang, Eliza W Beal, Matthew Weiss, Luca Aldrighetti, George A Poultsides, Todd W Bauer, Ryan C Fields, Shishir K Maithel, Hugo P Marques, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the study was to evaluate the impact of timing of disease occurrence and hepatic resection on long-term outcome of neuroendocrine liver metastasis (NELM). METHODS: A total of 420 patients undergoing curative-intent resection for NELM were identified from a multi-institutional database. Date of primary resection, NELM detection and resection, intraoperative details, disease-specific (DSS), and recurrence-free survival (RFS) were obtained...
September 20, 2017: Journal of Surgical Oncology
Masakuni Noguchi, Yukako Ohno, Emi Morioka, Miki Noguchi, Yasuharu Nakano, Takeo Kosaka, Ken-Ichi Shimada
No abstract text is available yet for this article.
September 20, 2017: Journal of Surgical Oncology
Giuseppe Marulli, Erino A Rendina, Walter Klepetko, Reinhold Perkmann, Davide Zampieri, Giulio Maurizi, Thomas Klikovits, Francesco Zaraca, Federico Venuta, Egle Perissinotto, Federico Rea
BACKGROUND: Few investigators have described en bloc resection of non-small cell lung cancer (NSCLC) invading the aorta. AIM OF STUDY: Analysis of outcome and prognostic factors for en bloc resections of NSCLC invading the aorta. METHODS: Thirty-five patients (27 males, 8 females; mean age 63 ± 8.6 years) were operated between 1994 and 2015 in four European Centers. HISTOLOGY: 12 (34.3%) squamous cell carcinoma, and 6 (17...
September 18, 2017: Journal of Surgical Oncology
Gianpiero Gravante, James Andrew Stephenson, Mohamed Elshaer, Ahmed Osman, Subramaniam Vasanthan, Joseph H Mullineux, Mohamed Akil Dilawar Gani, David Sharpe, Justin Yeung, Michael Norwood, Andrew Miller, Kirsten Boyle, David Hemingway
BACKGROUND AND OBJECTIVES: We reviewed our series of anal squamous cell carcinomas (ASCC) treated over the last two decades. METHODS: ASCC patients undergoing treatment at the Leicester Royal Infirmary between 1998 and 2016 were selected. Age, gender, pathological tumor characteristics, treatment adopted, the overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) at 5-year follow-up were recorded and calculated. RESULTS: A total of 190 ASCC were reviewed, of these 64...
September 10, 2017: Journal of Surgical Oncology
Carl R Schmidt
No abstract text is available yet for this article.
September 10, 2017: Journal of Surgical Oncology
Nardin Samuel, Resham Ejaz, Josh Silver, Shereen Ezzat, Robert J Cusimano, Raymond H Kim
Surgical management is the mainstay of therapy for primary cardiac tumors, yet due to the rarity of these malignancies, their management and workup remains a challenge. Here, we report a unique case of a patient with a primary left ventricular cardiac paraganglioma (PGL) and describe the role of a medical genetics assessment leading to the identification of a rare variant in the SDHB gene to be the causative etiology of this cardiac tumor. Due to decreasing costs and accessibility of molecular genetic analysis, genetic testing may become an emerging diagnostic adjunct in cases of cardiac tumors...
September 10, 2017: Journal of Surgical Oncology
Xu Sun, Teng Wang, Chun Zhang, Kuan Ning, Zhang-Rui Guan, Shu-Xian Chen, Ting-Ting Hong, Dong Hua
BACKGROUND: S100 is a superfamily of calcium-binding proteins that regulate multiple biological processes and are involved in many diseases. S100A16 has recently been identified to be involved in several cancers such as bladder cancer, lung cancer, and oral squamous cell carcinoma. However, the role of S100A16 expression in the colorectal cancer (CRC) has not been investigated. METHODS: S100A16 protein expression was detected by immunohistochemistry in 296 cases of CRC...
September 6, 2017: Journal of Surgical Oncology
Eugenio Ventimiglia, Yasin Folkvaljon, Stefan Carlsson, Ola Bratt, Francesco Montorsi, Daniela Volz, Olof Akre, Eva Johansson, Pär Stattin
OBJECTIVES: To assess the use of post radical prostatectomy (RP) urinary incontinence (PPI) surgery and to investigate factors related to its use. METHODS: Cohort study in Prostate Cancer database Sweden (PCBaSe) of men who underwent primary RP between 1998 and 2012. PPI correction procedures were identified in the Patient Registry. Hazard ratios (HR) and 95% confidence intervals (CIs) of PPI surgeries were estimated. RESULTS: Seven hundred eighty-two out of 26 280 (3%) men underwent PPI surgery at a median time of 3 years after RP...
September 6, 2017: Journal of Surgical Oncology
Long-Long Cong, Zhi-Qiang Cai, Peng Guo, Chen Chen, De-Chun Liu, Wen-Zhi Li, Lin Wang, Yaling Zhao, Shu-Bin Si, Zhi-Min Geng
BACKGROUND AND OBJECTIVES: To determine whether radical resection can benefit patients with advanced gallbladder adenocarcinoma using a Bayesian network (BN) with clinical data. METHODS: In total, 362 patients who had undergone surgical treatment of gallbladder adenocarcinoma at a tertiary institute were evaluated to establish two BN models using a tree-augmented naïve Bayes algorithm. We then chose 250 patients with T3-4N0-2M0 stage gallbladder adenocarcinoma to test the posterior probability after the surgical type was taken into account...
September 6, 2017: Journal of Surgical Oncology
Keigo Tani, Junichi Shindoh, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND AND OBJECTIVES: To clarify the detectability of gadolinium ethoxybenzyl diethylene-triamine pantaacetic acid enhanced magnetic resonance imaging (EOB-MRI) and contrast-enhanced intraoperative-ultrasonography (CE-IOUS) for residual disease in disappearing colorectal liver metastases (DLMs) and to seek a better management for DLMs. METHODS: Eighty-two patients who underwent hepatectomy after chemotherapy for colorectal liver metastases were retrospectively reviewed...
September 6, 2017: Journal of Surgical Oncology
Takuma Iwai, Takeshi Yamada, Michihiro Koizumi, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Kohki Takeda, Keisuke Hara, Keiichiro Ohta, Eiji Uchida
BACKGROUND AND OBJECTIVES: Oxaliplatin can cause hepatic sinusoidal obstruction syndrome (SOS). SOS can cause chemotherapy-related adverse effects or morbidity after liver resection. Conventionally, SOS is diagnosed using liver biopsy. Recently, it was reported that increased splenic volume (SV) can be used to detect SOS. In this study, we evaluated the changes in SV during adjuvant chemotherapy. METHODS: We enrolled 103 consecutive patients with stage III and high-risk stage II colorectal cancer treated with mFOLFOX6 (n = 37) or oral fluorouracil and leucovorin (n = 66) after curative surgery...
September 6, 2017: Journal of Surgical Oncology
Harzem Özger, Buğra Alpan, Osman Emre Aycan, Natig Valiyev, Mustafa Çağlar Kir, Fulya Ağaoğlu
BACKGROUND AND OBJECTIVE: Performing limb salvage with safe margins and preserving meaningful function is very difficult in the setting of primary malignant bone and soft tissue tumors due to the complex and constrained anatomy of the foot and ankle. The study aims to evaluate the efficacy of limb salvage procedures in terms of functional and oncological outcomes. METHODS: Clinical data of 48 patients, who underwent surgical treatment between 1992 and 2015 in our institution, were retrospectively analyzed...
September 6, 2017: Journal of Surgical Oncology
Carl R Schmidt
No abstract text is available yet for this article.
September 5, 2017: Journal of Surgical Oncology
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