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Journal of Surgical Oncology

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https://www.readbyqxmd.com/read/29761518/the-value-of-inflammation-based-prognostic-scores-in-patients-undergoing-surgical-resection-for-oesophageal-and-gastric-carcinoma
#1
Jiaxin Wen, Matthew Bedford, Ruksana Begum, Harriet Mitchell, James Hodson, John Whiting, Ewen Griffiths
BACKGROUND AND OBJECTIVES: Surgical interventions for oesophagogastric cancer carry a significant burden of morbidity and mortality. A range of inflammation based prognostic scores have been proposed in an attempt to predict outcome. This study evaluated five such prognostic scores in oesophageal and gastric carcinoma patients. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI), and Prognostic Nutrition Index (PNI) were calculated for 723 consecutive patients undergoing oesophagectomy or gastrectomy at a single center...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761515/association-of-perioperative-transfusion-with-survival-and-recurrence-after-resection-of-gallbladder-cancer-a-10-institution-study-from-the-us-extrahepatic-biliary-malignancy-consortium
#2
Alexandra G Lopez-Aguiar, Cecilia G Ethun, Mia R McInnis, Timothy M Pawlik, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza W Beal, Ioannis Hatzaras, Rivfka Shenoy, Kenneth Cardona, Shishir K Maithel
BACKGROUND AND OBJECTIVES: Perioperative blood transfusion is associated with poor outcomes in several malignancies. Its effect in gallbladder cancer (GBC) is unknown. METHODS: All patients with GBC who underwent curative-intent resection at 10-institutions from 2000 to 2015 were included. The effect of blood transfusion on overall survival (OS) and recurrence-free (RFS) was evaluated. RESULTS: Of 262 patients with curative-intent resection for GBC, 61 patients (23%) received blood transfusions...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761514/mandibular-reconstruction-in-elderly-patients
#3
Shimpei Miyamoto, Takuya Higashino, Minoru Sakuraba
BACKGROUND AND OBJECTIVES: The choice of reconstructive technique for a segmental mandibular defect in elderly patients is controversial. The aim of this study was to establish an algorithm for selecting a method of mandibular reconstruction in elderly patients. METHODS: We retrospectively evaluated 121 patients aged ≥65 years who underwent immediate microvascular mandibular reconstruction after oncologic resection. Patients were divided into three groups based on method of reconstruction: vascularized bone graft (n = 49), mandibular reconstruction plate and soft tissue flap (n = 22), and soft-tissue flap (n = 50)...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761510/initiation-of-adjuvant-therapy-following-surgical-resection-of-pancreatic-ductal-adenocarcinoma-pdac-are-patients-from-rural-remote-areas-disadvantaged
#4
Kimberly A Bertens, John D Massman, Scott Helton, Samuel Garbus, Margaret M Mandelson, Bruce Lin, Vincent J Picozzi, Thomas Biehl, Adnan A Alseidi, Flavio G Rocha
BACKGROUND AND OBJECTIVES: Although race and socioeconomic status have been shown to affect outcomes in pancreatic ductal adenocarcinoma (PDAC), the impact of rural residence on the delivery of adjuvant therapy (AT) has not been studied. METHODS: Patients with resected PDAC were identified using the National Cancer Database (NCDB). Individuals were classified as living in a metro area, urban/rural adjacent to a metro area (URA), and urban/rural remote (URR) area...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761507/upregulation-of-the-adipokine-genes-adipor1-and-spp1-is-related-to-poor-survival-outcomes-in-colorectal-cancer
#5
Eun K Choe, Jin W Yi, Young J Chai, Kyu J Park
BACKGROUND: Obesity is closely associated with colorectal cancer (CRC), but the underlying mechanism is unclear. We thus evaluated the expression of the adipokine gene family in CRC tissues and its clinicopathological implications. METHODS: Correlations between the mRNA expression levels of the adipokine gene family (ADIPOQ, ADIPOR1/2, LEP, LEPR, RETN, RETNLB, RBP4, SFRP5, NAMPT, and SPP1) in CRC tissue and clinicopathologic factors were analyzed using data from The Cancer Genome Atlas database...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29761503/evaluation-of-the-peritoneal-surface-disease-severity-score-psdss-in-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hipec-two-pathogenetic-types-based-study
#6
Roman Yarema, Taras Fetsych, Natalya Volodko, Myron Оhorchak, Orest Petronchak, Roman Huley, Yuriy Mylyan, Olivier Glehen
BACKGROUND AND OBJECTIVES: Clinical experience suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) play an important role in the management of ovarian cancer. In order to improve patient selection, the peritoneal surface disease severity score (PSDSS) was previously introduced for use in colorectal cancer patients. However, almost no data exist regarding the utility of the PSDSS index in ovarian cancer patients. METHODS: A retrospective study of the effectiveness of CRS and HIPEC was carried out in 59 patients with ovarian cancer...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723422/poorly-differentiated-clusters-in-colorectal-liver-metastases-prognostic-significance-in-synchronous-and-metachronous-metastases
#7
LETTER
Valeria Barresi, Simona Lionti, Luca Reggiani Bonetti
No abstract text is available yet for this article.
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723421/oral-rehabilitation-of-the-cancer-patient-a-formidable-challenge
#8
Ivana Petrovic, Evan B Rosen, Evan Matros, Joseph M Huryn, Jatin P Shah
Rehabilitation of oral functions following surgery on the jaws is a goal that is often difficult to achieve. Removable dentures supported by remaining teeth or gum are often unstable and seldom satisfactory. On the other hand, endosseous (dental) implants offer a mechanism to provide stability to the dentures. This review, discusses factors related to the tumor, patient, treatment, and physicians which impact upon the feasibility and success of dental implants in patients with oral cancer.
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723419/vein-resection-during-pancreaticoduodenectomy-for-pancreatic-adenocarcinoma-patency-rates-and-outcomes-associated-with-thrombosis
#9
Rebecca A Snyder, Laura R Prakash, Graciela M Nogueras-Gonzalez, Michael P Kim, Thomas A Aloia, Jean-Nicolas Vauthey, Jeffrey E Lee, Jason B Fleming, Matthew H G Katz, Ching-Wei D Tzeng
BACKGROUND AND OBJECTIVES: Venous patency rates after pancreaticoduodenectomy (PD) with portal vein (PV) resection are not well established, and the oncologic impact of portal vein thrombosis (PVT) is unknown. The primary aim of this study was to determine rates and predictors of PVT after PD with PV resection for pancreatic adenocarcinoma (PDAC). METHODS: A retrospective cohort study was performed on PDAC patients treated with preoperative therapy and PD with PV resection at a high-volume institution (2008-15)...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723413/reply-to-poorly-differentiated-clusters-in-colorectal-liver-metastases-prognostic-significance-in-synchronous-and-metachronous-metastases
#10
LETTER
Gilton M Fonseca, Evandro S de Mello, Fabricio F Coelho, Jaime A P Kruger, Sheila F Faraj, Vagner B Jeismann, Timothy M Pawlik, Paulo Herman
No abstract text is available yet for this article.
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723411/the-clinical-behavior-of-well-differentiated-liposarcoma-can-be-extremely-variable-a-retrospective-cohort-study-at-a-major-sarcoma-center
#11
Emily Z Keung, Naruhiko Ikoma, Robert Benjamin, Wei-Lien Wang, Alexander J Lazar, Barry W Feig
BACKGROUND: The pathogenesis of well differentiated liposarcoma (WDLPS) is poorly understood and pathologic characterization is often challenging. Descriptive terms (such as sclerosing, myxoid, inflammatory, spindle cell) are frequently encountered in the pathology reports and are of unknown clinical significance. METHODS: Sixty-two patients with primary retroperitoneal WDLPS resected at our institution were identified (1996-2011). Pathology reports of surgical resection specimens were retrospectively reviewed and descriptive qualifiers to the WDLPS diagnosis noted...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723410/the-association-between-preoperative-serum-interleukin-6-levels-and-postoperative-prognosis-in-patients-with-t2-gallbladder-cancer
#12
Jianfa Wang, Jiazhe Liu, Qimeng Chang, Biao Yang, Sen Li, Chao Gu
BACKGROUND: Interleukin-6 (IL-6) is closely associated with tumor progression. Whether it can predict postoperative prognosis of patients with T2 gallbladder cancer (GBC) remains controversial. METHODS: We retrospectively collected the medical records of 125 patients with T2 GBC. Then, we analyzed the association between preoperative serum IL-6 levels and postoperative survival by multivariate Cox analyses and Kaplan-Meier curves in exploratory subgroups. RESULTS: Predictive effects of serum IL-6 levels on overall survival were similar across most of the evaluated subgroups, except in different tumor location subgroups...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723405/cystic-bone-tumors-of-the-foot-and-ankle
#13
REVIEW
Bashar Reda
Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. This review discusses the most common cystic tumors of the foot and ankle including their radiographic features and principles of management.
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29723399/outcomes-of-microvascular-flap-reconstruction-of-the-head-and-neck-in-patients-receiving-systemic-immunosuppressive-therapy-for-organ-transplantation
#14
Mark V Schaverien, Riley A Dean, Jeffrey N Myers, Lin Fang, Rene D Largo, Peirong Yu
BACKGROUND: For organ transplant recipients, cancer secondary to immunosuppressive therapy threatens long-term survival. The associated multiple comorbidities make major free flap reconstruction following cancer surgery a complicated event. This study evaluates the outcomes of free flap reconstruction in this population. METHODS: A retrospective chart review of all head and neck free flap cases in patients with a history of organ transplantation receiving systemic immunosuppressive therapy between 2005 and 2017 at a single-institution was conducted...
May 3, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29714825/multi-center-retrospective-study-of-the-prognosis-and-treatment-outcomes-of-japanese-oral-squamous-cell-carcinoma-patients-with-single-lymph-node-metastasis-and-extra-nodal-extension
#15
Takumi Hasegawa, Souichi Yanamoto, Mitsunobu Otsuru, Yasumasa Kakei, Masaya Okura, Nobuhiro Yamakawa, Shin-Ichi Yamada, Yoshihide Ota, Masahiro Umeda, Tadaaki Kirita, Hiroshi Kurita, Michihiro Ueda, Takahide Komori
BACKGROUND: Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. OBJECTIVES: The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29714819/complete-posterior-sagittal-anorectal-mobilization-psam-a-new-surgical-approach-for-pediatric-pelvic-perineal-tumor-resections
#16
Giuseppe Martucciello, Luca Pio, Stefano Avanzini, Alberto Garaventa
INTRODUCTION: Diffuse or massive tumors involving the perineal and pelvic compartments may require aggressive surgical treatment in children. The authors, propose and present their results using a Posterior Sagittal Anorectal Mobilization (PSAM) METHODS: The oncologic patient is placed in a prone position with the pelvis elevated, without a previous colostomy. A 10 Ch bladder catheter is positioned. A midline sagittal incision is performed from the coccyx to the posterior margin of the anus...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29714816/sentinel-lymph-node-metastasis-in-primary-cutaneous-basosquamous-carcinoma-a-cross-sectional-study
#17
Despoina D Kakagia, Polyxeni Zapandioti, Grigoris Trypsiannis, Alexandra N Grekou, Dimosthenis Tsoutsos
BACKGROUND AND OBJECTIVES: Basosquamous carcinoma (BSC) is a rare, biologically aggressive tumor. This cross-sectional study aims to define risk factors for subclinical nodal metastasis in primary BSC, and identify the patients who would benefit from routine sentinel node biopsy (SLNB) as part of the initial management. METHODS: A total of 142 patients, with histologically proven BSC without palpable lymph nodes, underwent SLNB after the initial excision. Clinicopathological features and demographics were analyzed between the patients with detected micrometastasis (SLNM) and those with negative SLN...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29714811/gallbladder-carcinoma-an-analysis-of-the-national-cancer-data-base-to-examine-hispanic-influence
#18
Chrissy Liu, Nicholas G Berger, Lisa Rein, Sergey Tarima, Callisia Clarke, Harveshp Mogal, Kathleen K Christians, Susan Tsai, T Clark Gamblin
BACKGROUND: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations. METHODS: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined...
May 1, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29663399/multidimensional-analyses-of-the-learning-curve-for-single-incision-plus-one-port-laparoscopic-surgery-for-sigmoid-colon-and-upper-rectal-cancer
#19
Junmeng Li, Yanan Wang, Dong Liu, Haipeng Zhou, Tingyu Mou, Guoxin Li, Haijun Deng
BACKGROUND AND OBJECTIVES: Single-incision plus one port surgery (SILS + 1) provides the advantages of being minimally invasive and easier to perform than pure single-incision laparoscopic surgery. The aim of this study was to investigate the learning curve (LC) for SILS + 1 for sigmoid colon and upper rectal cancer. METHOD: From November 2012 to May 2014, a series of 85 consecutive patients underwent selective SLIS + 1 for sigmoid colon and upper rectal cancer performed by a single surgeon at Nanfang Hospital...
April 17, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29663398/transition-of-the-programmed-death-1-pathway-from-the-primary-colorectal-cancer-to-its-corresponding-pulmonary-metastasis
#20
Ei Miyamoto, Toyofumi F Chen-Yoshikawa, Chiyuki Ueshima, Akihiko Yoshizawa, Masatsugu Hamaji, Takamasa Yamamoto, Kenji Kawada, Hironori Haga, Yoshiharu Sakai, Hiroshi Date
BACKGROUND AND OBJECTIVES: The inhibition of the programmed death 1 (PD-1)/its ligand 1 (PD-L1) pathway may be associated with clinical responses in colorectal cancer (CRC). We aimed to characterize the transition of PD-1/PD-L1 expression through pulmonary metastasis (PM) and its clinical relevance. METHODS: This study retrospectively reviewed 50 patients who had curative resection of primary CRC and its PM. We evaluated the presence of PD-1+ tumor-infiltrating lymphocytes (TILs) and PD-L1+ tumor cells in both the primary tumor and its PM by immunohistochemistry...
April 17, 2018: Journal of Surgical Oncology
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