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Journal of Surgical Oncology

Sameer H Patel, Syed A Ahmad
No abstract text is available yet for this article.
June 29, 2018: Journal of Surgical Oncology
Fabio Bagante, Eliza W Beal, Katiuscha Merath, Anghela Paredes, Jeffery Chakedis, Griffin Olsen, Ozgür Akgül, Jay Idrees, Quinu Chen, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: Reducing readmissions is an important quality improvement metric. We sought to investigate patterns of 90-day readmission after hepato-pancreatic (HP) procedures. METHODS: The Nationwide Readmissions Database (NRD) was used to identify patients undergoing HP procedures between 2010 and 2014. Patients were stratified according to benign versus malignant HP diagnoses and as index (same hospital as operation) versus non-index (different hospital) readmissions...
June 29, 2018: Journal of Surgical Oncology
Simone Wigge, Klaus Heißner, Volker Steger, Ruth Ladurner, Frank Traub, Bence Sipos, Hans Bösmüller, Lothar Kanz, Frank Mayer, Hans-Georg Kopp
BACKGROUND AND OBJECTIVES: The role of local surgical procedures in patients with metastatic soft tissue sarcoma is still undefined. Few retrospective studies have reported survival benefits for patients with pulmonary metastases after complete surgical resection. Treatment decisions are therefore mainly based on personal experiences rather than on reproducible knowledge. METHOD: A total of 237 patients with metastatic sarcoma, treated between 1982 and 2015 at the University Hospital Tuebingen, Germany, were eligible for inclusion...
June 28, 2018: Journal of Surgical Oncology
Seok-Soo Byun, Eu C Hwang, Seok H Kang, Sung-Hoo Hong, Jinsoo Chung, Tae G Kwon, Hyeon H Kim, Cheol Kwak, Yong-June Kim, Won K Lee
BACKGROUND AND OBJECTIVES: The prognostic value of obesity is unestablished for renal cell carcinoma. We assessed the age-dependent prognostic value of body mass index (BMI) in a large multicenter cohort of patients with non-metastatic clear cell renal cell carcinoma (nm-cRCC). METHODS: This study evaluated 2092 patients with nm-cRCC who underwent surgery with curative intent at five Korean institutions between 2001 and 2014. RESULTS: There was no significant difference in BMI between the young (<45 years) and older patients (≥45 years) (P = 0...
June 27, 2018: Journal of Surgical Oncology
Aditya Mazmudar, Joshua Castle, Anthony D Yang, David J Bentrem
OBJECTIVE: The aim of this study was to identify if prolonged length of hospital stay was protective for certain post-discharge complications requiring readmission after pancreatectomy. METHODS: Patients undergoing elective pancreatectomy from 2012 to 2013 were identified in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). Multivariate regression analyses were conducted to elucidate the association of length of hospital stay (LOS), in-hospital complications, and post-discharge complications with 30-day hospital readmission...
June 27, 2018: Journal of Surgical Oncology
Naruhiko Ikoma, Wayne L Hofstetter, Jeannelyn S Estrella, Prajnan Das, Bruce D Minsky, Keith F Fournier, Paul F Mansfield, Jaffer A Ajani, Brian D Badgwell
BACKGROUND: Although the eighth-edition American Joint Committee on Cancer (AJCC) gastric cancer staging system created ypTNM staging for patients who underwent preoperative therapy, the ideal ypTNM grouping is unknown. We sought to investigate risk factors for OS in ypT0-3N0M0 gastric cancer. METHODS: From an institutional database of The University of Texas MD Anderson Cancer Center and the National Cancer Database (NCDB), we identified patients with ypT0-3N0M0 gastric adenocarcinoma who underwent R0 gastrectomy after chemotherapy or chemoradiation during 1995-2015 (MD Anderson) or 2006-2014 (NCDB)...
June 27, 2018: Journal of Surgical Oncology
Gannon L Curtis, Joshua M Lawrenz, Jaiben George, Joe F Styron, Jacob Scott, Chirag Shah, Dale R Shepard, Brian Rubin, Lukas M Nystrom, Nathan W Mesko
BACKGROUND: The primary goal of this investigation is to determine the current national standards for time to treatment initiation (TTI) in soft tissue sarcoma (STS). Additionally, we aim to identify the variables affecting TTI variability in STS. METHODS: An analysis of the National Cancer Database identified 41 529 patients diagnosed with STS between 2004 and 2013. Kruskall-Wallis tests identified differences between covariates regarding TTI. Negative binomial regression models identified variables that independently influenced TTI, and adjusted for confounders...
June 27, 2018: Journal of Surgical Oncology
Ajay Puri, Suman Byregowda, Ashish Gulia, Vijayraj Patil, Saniya Crasto, Siddharth Laskar
AIMS: Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites. MATERIALS AND METHODS: Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32)...
June 27, 2018: Journal of Surgical Oncology
Labrinus van Manen, Henricus J M Handgraaf, Michele Diana, Jouke Dijkstra, Takeaki Ishizawa, Alexander L Vahrmeijer, Jan Sven David Mieog
Near-infrared (NIR) fluorescence imaging is gaining clinical acceptance over the last years and has been used for detection of lymph nodes, several tumor types, vital structures and tissue perfusion. This review focuses on NIR fluorescence imaging with indocyanine green and methylene blue for different clinical applications in abdominal surgery with an emphasis on oncology, based on a systematic literature search. Furthermore, practical information on doses, injection times, and intraoperative use are provided...
June 24, 2018: Journal of Surgical Oncology
Judith E K R Hentzen, Steven J de Jongh, Patrick H J Hemmer, Willemijn Y van der Plas, Gooitzen M van Dam, Schelto Kruijff
Patients with peritoneal carcinomatosis (PC) from colorectal origin may undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as a curative approach. One major prognostic factor that affects survival is completeness of cytoreduction. Molecular Fluorescence Guided Surgery (MFGS) is a novel intraoperative imaging technique that may improve tumor identification in the future, potentially preventing over- and under-treatment in these patients. This narrative review outlines a chronological overview of MFGS development in patients with PC of colorectal origin...
June 24, 2018: Journal of Surgical Oncology
David A Mankoff, Sharyn I Katz
Positron emission tomography (PET) is a radioisotope imaging technique capable of quantifying the regional distribution of molecular imaging probes targeted to biochemical pathways and processes allowing direct measurement of biochemical changes induced by cancer therapy, including the activity of targeted growth pathways and cellular populations. In this manuscript, we review the underlying principles of PET imaging, choices for PET radiopharmaceuticals, methods for tumor analysis and PET applications for cancer therapy response assessment including potential future directions...
June 24, 2018: Journal of Surgical Oncology
Julie Beveridge, Muba Taher, Jay Zhu, Muhammad N Mahmood, Thomas G Salopek
BACKGROUND: No consensus exists regarding the best surgical strategy to achieve clear surgical margins while minimizing tissue excision when definitely excising lentigo maligna melanoma in situ (LM). The staged margin controlled excision (SMEX) technique is a modification of the spaghetti technique that allows surgeons to minimize margins and ensure complete excision of LM. OBJECTIVES: Our objectives were twofold: a) to evaluate the effectiveness of SMEX for treatment of LM and b) detail the SMEX technique...
June 24, 2018: Journal of Surgical Oncology
Yukie Fujimoto, Tomoko Higuchi, Arisa Nishimukai, Yoshimasa Miyagawa, Ayako Kira, Hiromi Ozawa, Ayako Bun, Michiko Imamura, Yasuo Miyoshi
BACKGROUND: To identify surrogate markers for prognosis of breast cancer patients with non-pathological complete response (non-pCR) to neoadjuvant chemotherapy (NAC), our investigation focused on serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA15-3) as well as clinicopathological factors both pre- and post-NAC. METHODS: A total of 185 breast cancer patients treated with NAC were recruited. Serum CEA and CA15-3 were measured at baseline and at completion of NAC...
June 24, 2018: Journal of Surgical Oncology
Michelle Coriddi, Elizabeth Kenworthy, Andrew Weinstein, Babak J Mehrara, Joseph H Dayan
BACKGROUND AND OBJECTIVE: Vascularized omentum lymphatic transplant (VOLT) for treatment of lymphedema has become popular because of no risk of iatrogenic lymphedema and abundant lymphatic tissue. However, perfusion to the omentum can be difficult to assess clinically. The purpose of this study was to clarify the incidence and degree of ischemia in the omentum. METHODS: A retrospective study was conducted to review indocyanine green perfusion findings on patients undergoing VOLT...
June 19, 2018: Journal of Surgical Oncology
Moshim Kukar, Emmanuel Gabriel, Kfir Ben-David, Steven N Hochwald
BACKGROUND: For cancers of the distal gastroesophageal junction or the proximal stomach, proximal gastrectomy can be performed. It is associated with several perioperative benefits compared with total gastrectomy. The use of laparoscopic proximal gastrectomy (LPG) has become an increasingly popular approach for select tumors. METHODS: We describe our method of LPG, including the preoperative work-up, illustrated depictions of the key steps of the surgery, and our postoperative pathway...
June 19, 2018: Journal of Surgical Oncology
Emily Le Souder, Arash Azin, Trevor Wood, Dhruvin Hirpara, Ahmad Elnahas, Sean Cleary, Alice Wei, Richard Walker, Armen Parsyan, Sami Chadi, Fayez Quereshy
BACKGROUND AND OBJECTIVES: Patients with colorectal cancer with synchronous liver metastases may undergo a staged or a simultaneous resection. This study aimed to determine whether the time to adjuvant chemotherapy was delayed in patients undergoing a simultaneous resection. METHODS: A retrospective cohort study was conducted between 2005 and 2016. The primary outcome was time to adjuvant chemotherapy. A multivariate linear regression was conducted to ascertain the adjusted effect of a simultaneous versus a staged approach on time to adjuvant chemotherapy...
June 7, 2018: Journal of Surgical Oncology
Kai-Wen Huang, Po-Chih Yang, Uei Pua, Man-Deuk Kim, Sheng-Ping Li, Yu-Dong Qiu, Tian-Qiang Song, Po-Chin Liang
BACKGROUND AND OBJECTIVES: Irreversible electroporation (IRE) is a non-thermal focal therapy that utilizes high voltage electric pulses to permanently rupture the cellular membrane and induce cell death. In this multi-center study, we evaluated the safety and efficacy of IRE in patients with locally advanced pancreatic cancer (LAPC). METHODS: From 2012 to 2015, we performed laparotomic and laparoscopic IRE in a total of 70 patients with stage III LAPC. Either gemcitabine-based or TS-1 (Tegafur, Gimeracil, and Oteracil) chemotherapy was applied for at least 3 months before the IRE...
June 7, 2018: Journal of Surgical Oncology
Oliver S Eng, Mustafa Raoof, Andrew M Blakely, Xian Yu, Stephen J Lee, Ernest S Han, Mark T Wakabayashi, Bertram Yuh, Byrne Lee, Thanh H Dellinger
BACKGROUND AND OBJECTIVES: Cytoreductive surgery with complete macroscopic resection in patients with ovarian cancer is associated with improved survival. Institutional reports of combined upper and lower abdominal cytoreductive surgery for more advanced disease have described multidisciplinary approaches. We sought to investigate outcomes in patients undergoing cytoreductive surgery in patients with upper and lower abdominal disease at our institution. METHODS: Patients who underwent cytoreductive surgery for ovarian malignancies from 2008 to 2015 were retrospectively identified from an institutional database...
June 7, 2018: Journal of Surgical Oncology
Tian Meng, Xiao-Hua Shi, Sha-Fei Wu, Yu-Feng Luo, Xiao-Jun Wang, Xiao Long
BACKGROUND AND OBJECTIVES: Dermatofibrosarcoma protuberans (DFSP) is a relatively rare skin tumor. Clinical observations indicated that DFSP has a more aggressive behavior during pregnancy, which suggest there might be a hormonal influence on this tumor. We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) in DFSP patients. METHODS: In our present case series, patients with histopathological-confirmed DFSP at a single institution were identified...
June 7, 2018: Journal of Surgical Oncology
Baichuan Wang, Qiang Wu, Zhicai Zhang, Jianxiang Liu, Zengwu Shao
BACKGROUND: Surgical reconstruction after total scapulectomy presents a great challenge. Currently, the constrained scapular prosthesis reconstruction is considered as the most effective and promising method. However, the mid- to long-term functional outcomes and complications of this procedure are unclear. METHODS: We retrospectively analyzed eight patients with scapular malignant tumors treated by total scapulectomy and constrained scapular prosthesis reconstruction between 2011 and 2013...
June 7, 2018: Journal of Surgical Oncology
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